Gabriel Heymann - Related publications

2011-2013 University of Washington School of Medicine, Seattle, WA, United States 
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50 most relevant papers in past 60 days:
Year Citation  Score
2020 Frei JN, Broadhurst RW, Bostock MJ, Solt A, Jones AJY, Gabriel F, Tandale A, Shrestha B, Nietlispach D. Conformational plasticity of ligand-bound and ternary GPCR complexes studied by F NMR of the β-adrenergic receptor. Nature Communications. 11: 669. PMID 32015348 DOI: 10.1038/s41467-020-14526-3   
2020 Trenker R, Jura N. Receptor tyrosine kinase activation: From the ligand perspective. Current Opinion in Cell Biology. 63: 174-185. PMID 32114309 DOI: 10.1016/   
2020 Randáková A, Nelic D, Doležal V, El-Fakahany EE, Boulos J, Jakubík J. Agonist-Specific Conformations of the M Muscarinic Acetylcholine Receptor Assessed by Molecular Dynamics. Journal of Chemical Information and Modeling. PMID 32130001 DOI: 10.1021/acs.jcim.0c00041   
2020 Wilmes S, Hafer M, Vuorio J, Tucker JA, Winkelmann H, Löchte S, Stanly TA, Pulgar Prieto KD, Poojari C, Sharma V, Richter CP, Kurre R, Hubbard SR, Garcia KC, Moraga I, et al. Mechanism of homodimeric cytokine receptor activation and dysregulation by oncogenic mutations. Science (New York, N.Y.). 367: 643-652. PMID 32029621 DOI: 10.1126/science.aaw3242   
2020 Hu B, Joseph J, Geng X, Wu Y, Suleiman MR, Liu X, Shi J, Wang X, He Z, Wang J, Cheng M. Refined pharmacophore features for virtual screening of human thromboxane A2 receptor antagonists. Computational Biology and Chemistry. 86: 107249. PMID 32199335 DOI: 10.1016/j.compbiolchem.2020.107249   
2020 Garces F, Mohr C, Zhang L, Huang CS, Chen Q, King C, Xu C, Wang Z. Molecular Insight into Recognition of the CGRPR Complex by Migraine Prevention Therapy Aimovig (Erenumab). Cell Reports. 30: 1714-1723.e6. PMID 32049005 DOI: 10.1016/j.celrep.2020.01.029   
2020 Chan HCS, Xu Y, Tan L, Vogel H, Cheng J, Wu D, Yuan S. Enhancing the Signaling of GPCRs via Orthosteric Ions. Acs Central Science. 6: 274-282. PMID 32123746 DOI: 10.1021/acscentsci.9b01247   
2020 Jatczak-Śliwa M, Kisiel M, Czyzewska MM, Brodzki M, Mozrzymas JW. GABA Receptor βE155 Residue Located at the Agonist-Binding Site Is Involved in the Receptor Gating. Frontiers in Cellular Neuroscience. 14: 2. PMID 32116555 DOI: 10.3389/fncel.2020.00002   
2020 Wang R, Qi X, Schmiege P, Coutavas E, Li X. Marked structural rearrangement of mannose 6-phosphate/IGF2 receptor at different pH environments. Science Advances. 6: eaaz1466. PMID 32095534 DOI: 10.1126/sciadv.aaz1466   
2020 Wingler LM, Skiba MA, McMahon C, Staus DP, Kleinhenz ALW, Suomivuori CM, Latorraca NR, Dror RO, Lefkowitz RJ, Kruse AC. Angiotensin and biased analogs induce structurally distinct active conformations within a GPCR. Science (New York, N.Y.). 367: 888-892. PMID 32079768 DOI: 10.1126/science.aay9813   
2020 Shang J, Wan Y, Liu C, Yount B, Gully K, Yang Y, Auerbach A, Peng G, Baric R, Li F. Structure of mouse coronavirus spike protein complexed with receptor reveals mechanism for viral entry. Plos Pathogens. 16: e1008392. PMID 32150576 DOI: 10.1371/journal.ppat.1008392   
2020 Kozma MT, Ngo-Vu H, Wong YY, Shukla NS, Pawar SD, Senatore A, Schmidt M, Derby CD. Comparison of transcriptomes from two chemosensory organs in four decapod crustaceans reveals hundreds of candidate chemoreceptor proteins. Plos One. 15: e0230266. PMID 32163507 DOI: 10.1371/journal.pone.0230266   
2020 Wang J, Wu M, Wu L, Xu Y, Li F, Wu Y, Popov P, Wang L, Bai F, Zhao S, Liu ZJ, Hua T. The structural study of mutation-induced inactivation of human muscarinic receptor M4. Iucrj. 7: 294-305. PMID 32148857 DOI: 10.1107/S2052252520000597   
2020 Chang R, Hernandez J, Gastelum C, Guadagno K, Perez L, Wagner EJ. Pituitary Adenylate Cyclase Activating Polypeptide Excites Proopiomelanocortin Neurons: Implications for the Regulation of Energy Homeostasis. Neuroendocrinology. PMID 32028278 DOI: 10.1159/000506367   
2020 Stoeber M, Jullié D, Li J, Chakraborty S, Majumdar S, Lambert NA, Manglik A, von Zastrow M. Agonist-selective recruitment of engineered protein probes and of GRK2 by opioid receptors in living cells. Elife. 9. PMID 32096468 DOI: 10.7554/eLife.54208   
2020 Sanchez-Soto M, Verma RK, Willette BKA, Gonye EC, Moore AM, Moritz AE, Boateng CA, Yano H, Free RB, Shi L, Sibley DR. A structural basis for how ligand binding site changes can allosterically regulate GPCR signaling and engender functional selectivity. Science Signaling. 13. PMID 32019899 DOI: 10.1126/scisignal.aaw5885   
2020 Pierce ML, French JA, Murray TF. Comparison of the pharmacological profiles of arginine vasopressin and oxytocin analogs at marmoset, macaque, and human vasopressin 1a receptor. Biomedicine & Pharmacotherapy = Biomedecine & Pharmacotherapie. 126: 110060. PMID 32145592 DOI: 10.1016/j.biopha.2020.110060   
2020 Krieger CC, Neumann S, Gershengorn MC. TSH/IGF1 receptor crosstalk: Mechanism and clinical implications. Pharmacology & Therapeutics. 107502. PMID 32061922 DOI: 10.1016/j.pharmthera.2020.107502   
2020 Jégouzo SAF, Nelson C, Hardwick T, Wong STA, Lau NKK, Neoh GKE, Castellanos-Rueda R, Huang Z, Mignot B, Hirdaramani A, Howitt A, Frewin K, Shen Z, Fox RJ, Wong R, et al. Mammalian lectin arrays for screening host-microbe interactions. The Journal of Biological Chemistry. PMID 32094229 DOI: 10.1074/jbc.RA120.012783   
2020 Jaremko W, Huang Z, Karl N, Pierce VD, Lynch J, Niu L. A kainate receptor-selective RNA aptamer. The Journal of Biological Chemistry. PMID 32161119 DOI: 10.1074/jbc.RA119.011649   
2020 Lynch DL, Hurst DP, Reggio PH. The Nucleotide-Free State of the Cannabinoid CB2/Gi Complex. Cell. 180: 603-604. PMID 32084338 DOI: 10.1016/j.cell.2020.01.034   
2020 Gulsevin A, Papke RL, Horenstein N. In silico modeling of the α7 nicotinic acetylcholine receptor: new pharmacological challenges associated with multiple modes of signaling. Mini Reviews in Medicinal Chemistry. PMID 32000651 DOI: 10.2174/1389557520666200130105256   
2020 White CW, Caspar B, Vanyai HK, Pfleger KDG, Hill SJ. CRISPR-Mediated Protein Tagging with Nanoluciferase to Investigate Native Chemokine Receptor Function and Conformational Changes. Cell Chemical Biology. PMID 32053779 DOI: 10.1016/j.chembiol.2020.01.010   
2020 Congreve M, de Graaf C, Swain NA, Tate CG. Impact of GPCR Structures on Drug Discovery. Cell. 181: 81-91. PMID 32243800 DOI: 10.1016/j.cell.2020.03.003   
2020 Blaber S, Sivak DA. Optimal control of protein copy number. Physical Review. E. 101: 022118. PMID 32168689 DOI: 10.1103/PhysRevE.101.022118   
2020 Giribaldi J, Ragnarsson L, Pujante T, Enjalbal C, Wilson D, Daly NL, Lewis RJ, Dutertre S. Synthesis, Pharmacological and Structural Characterization of Novel Conopressins from . Marine Drugs. 18. PMID 32155768 DOI: 10.3390/md18030150   
2020 Su Z, Wu Y. A Systematic Test of Receptor Binding Kinetics for Ligands in Tumor Necrosis Factor Superfamily by Computational Simulations. International Journal of Molecular Sciences. 21. PMID 32150842 DOI: 10.3390/ijms21051778   
2020 Fan L, Tan L, Chen Z, Qi J, Nie F, Luo Z, Cheng J, Wang S. Haloperidol bound D dopamine receptor structure inspired the discovery of subtype selective ligands. Nature Communications. 11: 1074. PMID 32103023 DOI: 10.1038/s41467-020-14884-y   
2020 Mayasich SA, Clarke BL. Vasotocin and the origins of the vasopressin/oxytocin receptor gene family. Vitamins and Hormones. 113: 1-27. PMID 32138945 DOI: 10.1016/bs.vh.2019.08.018   
2020 Sullivan HJ, Tursi A, Moore K, Campbell A, Floyd C, Wu C. Binding interactions of ergotamine and dihydroergotamine to 5-hydroxytryptamine receptor 1B (5-HT1b) using Molecular Dynamics Simulations and Dynamic Network Analysis. Journal of Chemical Information and Modeling. PMID 32078320 DOI: 10.1021/acs.jcim.9b01082   
2020 Zhang H, Bai J, Huang S, Liu H, Lin J, Hou Y. Neuropeptides and G-Protein Coupled Receptors (GPCRs) in the Red Palm Weevil Olivier (Coleoptera: Dryophthoridae). Frontiers in Physiology. 11: 159. PMID 32184735 DOI: 10.3389/fphys.2020.00159   
2020 Deganutti G, Moro S, Reynolds CA. A Supervised Molecular Dynamics Approach to Unbiased Ligand-Protein Unbinding. Journal of Chemical Information and Modeling. PMID 32126172 DOI: 10.1021/acs.jcim.9b01094   
2020 Shen D, Shen X, Schwarz W, Grygorczyk R, Wang L. P2Y and P2X receptors modulate mechanically induced adenosine triphosphate release from mast cells. Experimental Dermatology. PMID 32155290 DOI: 10.1111/exd.14093   
2020 Kobayashi K, Shihoya W, Nishizawa T, Kadji FMN, Aoki J, Inoue A, Nureki O. Cryo-EM structure of the human PAC1 receptor coupled to an engineered heterotrimeric G protein. Nature Structural & Molecular Biology. 27: 274-280. PMID 32157248 DOI: 10.1038/s41594-020-0386-8   
2020 Duplaquet L, Leroy C, Vinchent A, Paget S, Lefebvre J, Vanden Abeele F, Lancel S, Giffard F, Paumelle R, Bidaux G, Heliot L, Poulain L, Furlan A, Tulasne D. Control of cell death/survival balance by the MET dependence receptor. Elife. 9. PMID 32091387 DOI: 10.7554/eLife.50041   
2020 Kayser S, Temperini P, Poulie CBM, Staudt M, Nielsen B, Pickering DS, Bunch L. A Diversity Oriented Synthesis Approach to New 2,3--Substituted l-Proline Analogs as Potential Ligands for the Ionotropic Glutamate Receptors. Acs Chemical Neuroscience. PMID 32069018 DOI: 10.1021/acschemneuro.0c00005   
2020 Kowalski CW, Lindberg JEM, Fowler DK, Simasko SM, Peters JH. Contributing mechanisms underlying desensitization of CCK-induced activation of primary nodose ganglia neurons. American Journal of Physiology. Cell Physiology. PMID 32073876 DOI: 10.1152/ajpcell.00192.2019   
2020 Goncharuk MV, Roy D, Dubinnyi MA, Nadezhdin KD, Srivastava A, Baidya M, Dwivedi-Agnihotri H, Arseniev AS, Shukla AK. Purification of native CCL7 and its functional interaction with selected chemokine receptors. Protein Expression and Purification. 105617. PMID 32145391 DOI: 10.1016/j.pep.2020.105617   
2020 Chang HJ, Bonnet J. Synthetic receptors to understand and control cellular functions. Methods in Enzymology. 633: 143-167. PMID 32046843 DOI: 10.1016/bs.mie.2019.11.011   
2020 Boursier ME, Levin S, Zimmerman K, Machleidt T, Hurst R, Butler BL, Eggers CT, Kirkland TA, Wood KV, Friedman Ohana R. The luminescent HiBiT peptide enables selective quantitation of GPCR ligand engagement and internalization in living cells. The Journal of Biological Chemistry. PMID 32107310 DOI: 10.1074/jbc.RA119.011952   
2020 Khalafalla MG, Woods LT, Jasmer KJ, Forti KM, Camden JM, Jensen JL, Limesand KH, Galtung HK, Weisman GA. P2 Receptors as Therapeutic Targets in the Salivary Gland: From Physiology to Dysfunction. Frontiers in Pharmacology. 11: 222. PMID 32231563 DOI: 10.3389/fphar.2020.00222   
2020 Matyśniak D, Nowak N, Pomorski P. P2X7 receptor activity landscape in rat and human glioma cell lines. Acta Biochimica Polonica. 67: 7-14. PMID 32187491 DOI: 10.18388/abp.2020_2848   
2020 Zhuang Y, Liu H, Edward Zhou X, Kumar Verma R, de Waal PW, Jang W, Xu TH, Wang L, Meng X, Zhao G, Kang Y, Melcher K, Fan H, Lambert NA, Eric Xu H, et al. Structure of formylpeptide receptor 2-G complex reveals insights into ligand recognition and signaling. Nature Communications. 11: 885. PMID 32060286 DOI: 10.1038/s41467-020-14728-9   
2020 Karki A, Juarez R, Namballa HK, Alberts I, Harding WW. Identification of C10 nitrogen-containing aporphines with dopamine D versus D receptor selectivity. Bioorganic & Medicinal Chemistry Letters. 127053. PMID 32107165 DOI: 10.1016/j.bmcl.2020.127053   
2020 Lian JJ, Cao YQ, Li YL, Yu G, Su RB. Flumazenil-Insensitive Benzodiazepine Effects in Recombinant αβ and Neuronal GABA Receptors. Brain Sciences. 10. PMID 32150806 DOI: 10.3390/brainsci10030150   
2020 Li J, Wang L, Tian J, Zhou Z, Li J, Yang H. Nongenetic engineering strategies for regulating receptor oligomerization in living cells. Chemical Society Reviews. PMID 32040109 DOI: 10.1039/c9cs00473d   
2020 Kuder KJ, Michalik I, Kieć-Kononowicz K, Kolb P. A Taxicab geometry quantification system to evaluate the performance of in silico methods: a case study on adenosine receptors ligands. Journal of Computer-Aided Molecular Design. PMID 32112287 DOI: 10.1007/s10822-020-00301-5   
2020 He X, Yan L, Wu Q, Zhang G, Zhou N. Ligand-dependent internalization of Bombyx mori tachykinin-related peptide receptor is regulated by PKC, GRK5 and β-arrestin2/BmKurtz. Biochimica Et Biophysica Acta. Molecular Cell Research. 118690. PMID 32112783 DOI: 10.1016/j.bbamcr.2020.118690   
2020 Christie AE, Hull JJ, Dickinson PS. Assessment and comparison of putative amine receptor complement/diversity in the brain and eyestalk ganglia of the lobster, Homarus americanus. Invertebrate Neuroscience : In. 20: 7. PMID 32215729 DOI: 10.1007/s10158-020-0239-5   
2020 Rao BD, Sarkar P, Chattopadhyay A. Selectivity in agonist and antagonist binding to Serotonin receptors via G-protein coupling. Biochimica Et Biophysica Acta. Biomembranes. 183265. PMID 32156647 DOI: 10.1016/j.bbamem.2020.183265