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David Hackos - Publications

Affiliations: 
1998-2001 Neuroscience Genentech, Inc., San Francisco, CA, United States 
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18 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2023 Kschonsak M, Jao CC, Arthur CP, Rohou AL, Bergeron P, Ortwine DF, McKerrall SJ, Hackos DH, Deng L, Chen J, Li T, Dragovich PS, Volgraf M, Wright MR, Payandeh J, et al. Cryo-EM reveals an unprecedented binding site for Na1.7 inhibitors enabling rational design of potent hybrid inhibitors. Elife. 12. PMID 36975198 DOI: 10.7554/eLife.84151  0.386
2020 Liu C, Reese R, Vu S, Rougé L, Shields SD, Kakiuchi-Kiyota S, Chen H, Johnson K, Shi YP, Chernov-Rogan T, Greiner DMZ, Kohli PB, Hackos D, Brillantes B, Tam C, et al. A Non-covalent Ligand Reveals Biased Agonism of the TRPA1 Ion Channel. Neuron. PMID 33152265 DOI: 10.1016/j.neuron.2020.10.014  0.386
2019 Chernov-Rogan T, Gianti E, Liu C, Villemure E, Cridland AP, Hu X, Ballini E, Lange W, Deisemann H, Li T, Ward SI, Hackos DH, Magnuson S, Safina B, Klein ML, et al. TRPA1 modulation by piperidine carboxamides suggests an evolutionarily conserved binding site and gating mechanism. Proceedings of the National Academy of Sciences of the United States of America. PMID 31796582 DOI: 10.1073/Pnas.1913929116  0.443
2019 Xu H, Li T, Rohou A, Arthur CP, Tzakoniati F, Wong E, Estevez A, Kugel C, Franke Y, Chen J, Ciferri C, Hackos DH, Koth CM, Payandeh J. Structural Basis of Nav1.7 Inhibition by a Gating-Modifier Spider Toxin. Cell. 176: 1238-1239. PMID 30794776 DOI: 10.1016/j.cell.2019.01.047  0.305
2019 Clairfeuille T, Cloake A, Infield DT, Llongueras JP, Arthur CP, Li ZR, Jian Y, Martin-Eauclaire MF, Bougis PE, Ciferri C, Ahern CA, Bosmans F, Hackos DH, Rohou A, Payandeh J. Structural basis of α-scorpion toxin action on Nav channels. Science (New York, N.Y.). PMID 30733386 DOI: 10.1126/Science.Aav8573  0.753
2019 Xu H, Li T, Rohou A, Arthur CP, Tzakoniati F, Wong E, Estevez A, Kugel C, Franke Y, Chen J, Ciferri C, Hackos DH, Koth CM, Payandeh J. Structural Basis of Nav1.7 Inhibition by a Gating-Modifier Spider Toxin. Cell. PMID 30661758 DOI: 10.2210/Pdb6N4Q/Pdb  0.61
2018 Payandeh J, Hackos DH. Selective Ligands and Drug Discovery Targeting the Voltage-Gated Sodium Channel Nav1.7. Handbook of Experimental Pharmacology. 246: 271-306. PMID 29532179 DOI: 10.1007/164_2018_97  0.449
2018 Chernov-Rogan T, Li T, Lu G, Verschoof H, Khakh K, Jones SW, Beresini MH, Liu C, Ortwine DF, McKerrall SJ, Hackos DH, Sutherlin D, Cohen CJ, Chen J. Mechanism-specific assay design facilitates the discovery of Nav1.7-selective inhibitors. Proceedings of the National Academy of Sciences of the United States of America. PMID 29311306 DOI: 10.1073/Pnas.1713701115  0.34
2017 Wang TM, Brown BM, Deng L, Sellers BD, Lupardus PJ, Wallweber HJA, Gustafson A, Wong E, Volgraf M, Schwarz JB, Hackos DH, Hanson JE. A novel NMDA receptor positive allosteric modulator that acts via the transmembrane domain. Neuropharmacology. PMID 28457974 DOI: 10.1016/J.Neuropharm.2017.04.041  0.356
2015 Ahuja S, Mukund S, Deng L, Khakh K, Chang E, Ho H, Shriver S, Young C, Lin S, Johnson JP, Wu P, Li J, Coons M, Tam C, Brillantes B, ... ... Hackos DH, et al. Structural basis of Nav1.7 inhibition by an isoform-selective small-molecule antagonist. Science (New York, N.Y.). 350: aac5464. PMID 26680203 DOI: 10.1126/Science.Aac5464  0.573
2015 Chen J, Hackos DH. TRPA1 as a drug target--promise and challenges. Naunyn-Schmiedeberg's Archives of Pharmacology. 388: 451-63. PMID 25640188 DOI: 10.1007/s00210-015-1088-3  0.35
2003 Sukhareva M, Hackos DH, Swartz KJ. Constitutive activation of the Shaker Kv channel. The Journal of General Physiology. 122: 541-56. PMID 14557403 DOI: 10.1085/Jgp.200308905  0.653
2002 Hackos DH, Chang TH, Swartz KJ. Scanning the intracellular S6 activation gate in the shaker K+ channel. The Journal of General Physiology. 119: 521-32. PMID 12034760 DOI: 10.1085/Jgp.20028569  0.763
2000 Frings S, Hackos DH, Dzeja C, Ohyama T, Hagen V, Kaupp UB, Korenbrot JI. Determination of fractional calcium ion current in cyclic nucleotide-gated channels. Methods in Enzymology. 315: 797-817. PMID 10736742 DOI: 10.1016/S0076-6879(00)15883-5  0.396
2000 Li-Smerin Y, Hackos DH, Swartz KJ. A localized interaction surface for voltage-sensing domains on the pore domain of a K+ channel. Neuron. 25: 411-23. PMID 10719895 DOI: 10.1016/S0896-6273(00)80904-6  0.631
2000 Li-Smerin Y, Hackos DH, Swartz KJ. alpha-helical structural elements within the voltage-sensing domains of a K(+) channel. The Journal of General Physiology. 115: 33-50. PMID 10613917 DOI: 10.1085/Jgp.115.1.33  0.618
1999 Hackos DH, Korenbrot JI. Divalent cation selectivity is a function of gating in native and recombinant cyclic nucleotide-gated ion channels from retinal photoreceptors. The Journal of General Physiology. 113: 799-818. PMID 10352032 DOI: 10.1085/jgp.113.6.799  0.497
1997 Hackos DH, Korenbrot JI. Calcium modulation of ligand affinity in the cyclic GMP-gated ion channels of cone photoreceptors. The Journal of General Physiology. 110: 515-28. PMID 9348324 DOI: 10.1085/jgp.110.5.515  0.47
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