| Year |
Citation |
Score |
| 2023 |
Alexander SPH, Mathie AA, Peters JA, Veale EL, Striessnig J, Kelly E, Armstrong JF, Faccenda E, Harding SD, Davies JA, Aldrich RW, Attali B, Baggetta AM, Becirovic E, Biel M, ... ... Lynch JW, et al. The Concise Guide to PHARMACOLOGY 2023/24: Ion channels. British Journal of Pharmacology. S145-S222. PMID 38123150 DOI: 10.1111/bph.16178 |
0.304 |
|
| 2021 |
Alexander SP, Mathie A, Peters JA, Veale EL, Striessnig J, Kelly E, Armstrong JF, Faccenda E, Harding SD, Pawson AJ, Southan C, Davies JA, Aldrich RW, Attali B, Baggetta AM, ... ... Lynch JW, et al. THE CONCISE GUIDE TO PHARMACOLOGY 2021/22: Ion channels. British Journal of Pharmacology. 178: S157-S245. PMID 34529831 DOI: 10.1111/bph.15539 |
0.3 |
|
| 2020 |
Di XJ, Wang YJ, Cotter E, Wang M, Whittsette AL, Han DY, Sangwung P, Brown R, Lynch JW, Keramidas A, Mu TW. Proteostasis Regulators Restore Function of Epilepsy-Associated GABA Receptors. Cell Chemical Biology. PMID 32888501 DOI: 10.1016/J.Chembiol.2020.08.012 |
0.485 |
|
| 2020 |
Langlhofer G, Schaefer N, Maric HM, Keramidas A, Zhang Y, Baumann P, Blum R, Breitinger U, Strømgaard K, Schlosser A, Kessels MM, Koch D, Qualmann B, Breitinger HG, Lynch JW, et al. A novel glycine receptor variant with startle disease affects syndapin I and glycinergic inhibition. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. PMID 32354853 DOI: 10.1523/Jneurosci.2490-19.2020 |
0.519 |
|
| 2020 |
Chen X, Keramidas A, Harvey RJ, Lynch JW. Effects of GluN2A and GluN2B gain-of-function epilepsy mutations on synaptic currents mediated by diheteromeric and triheteromeric NMDA receptors. Neurobiology of Disease. 104850. PMID 32247039 DOI: 10.1016/J.Nbd.2020.104850 |
0.38 |
|
| 2020 |
Baenziger JE, Henault CM, Govaerts C, Estrada A, Lynch J, Bertrand D, Pardon E, Evans G, Woods KN, Elberson BW, Cuello LG, Brannigan GH, Nury H, Steyaert J, Ulens C. A Lipid Recognition Site at a Transmembrane Helix Kink Shapes the Agonist Response of a Pentameric Ligand-gated Ion Channel Biophysical Journal. 118: 191a. DOI: 10.1016/J.Bpj.2019.11.1156 |
0.415 |
|
| 2019 |
Han W, Li J, Pelkey KA, Pandey S, Chen X, Wang YX, Wu K, Ge L, Li T, Castellano D, Liu C, Wu LG, Petralia RS, Lynch JW, McBain CJ, et al. Shisa7 is a GABA receptor auxiliary subunit controlling benzodiazepine actions. Science (New York, N.Y.). 366: 246-250. PMID 31601770 DOI: 10.1126/Science.Aax5719 |
0.492 |
|
| 2019 |
Hénault CM, Govaerts C, Spurny R, Brams M, Estrada-Mondragon A, Lynch J, Bertrand D, Pardon E, Evans GL, Woods K, Elberson BW, Cuello LG, Brannigan G, Nury H, Steyaert J, et al. A lipid site shapes the agonist response of a pentameric ligand-gated ion channel. Nature Chemical Biology. PMID 31591563 DOI: 10.1038/S41589-019-0369-4 |
0.751 |
|
| 2019 |
Atif M, Lynch JW, Keramidas A. The effects of insecticides on two splice variants of the glutamate-gated chloride channel receptor of the major malaria vector, Anopheles gambiae. British Journal of Pharmacology. PMID 31479507 DOI: 10.1111/Bph.14855 |
0.401 |
|
| 2019 |
Atif M, Smith JJ, Estrada-Mondragon A, Xiao X, Salim AA, Capon RJ, Lynch JW, Keramidas A. GluClR-mediated inhibitory postsynaptic currents reveal targets for ivermectin and potential mechanisms of ivermectin resistance. Plos Pathogens. 15: e1007570. PMID 30695069 DOI: 10.1371/Journal.Ppat.1007570 |
0.751 |
|
| 2019 |
Lynch JW, Sivilotti LG, Smart TG. Glycine receptors (version 2019.4) in the IUPHAR/BPS Guide to Pharmacology Database Iuphar/Bps Guide to Pharmacology Cite. 2019. DOI: 10.2218/gtopdb/f73/2019.4 |
0.369 |
|
| 2018 |
Durisic N, Keramidas A, Dixon CL, Lynch JW. SAHA (Vorinostat) Corrects Inhibitory Synaptic Deficits Caused by Missense Epilepsy Mutations to the GABA Receptor γ2 Subunit. Frontiers in Molecular Neuroscience. 11: 89. PMID 29628874 DOI: 10.3389/Fnmol.2018.00089 |
0.387 |
|
| 2018 |
Leacock S, Syed P, James VM, Bode A, Kawakami K, Keramidas A, Suster M, Lynch JW, Harvey RJ. Structure/Function Studies of the α4 Subunit Reveal Evolutionary Loss of a GlyR Subtype Involved in Startle and Escape Responses. Frontiers in Molecular Neuroscience. 11: 23. PMID 29445326 DOI: 10.3389/Fnmol.2018.00023 |
0.385 |
|
| 2018 |
Perumal MB, Lynch JW, Sah P. GABA A receptors and inhibitory neurotransmission in the amygdalar complex Current Opinion in Physiology. 2: 58-64. DOI: 10.1016/J.Cophys.2018.01.003 |
0.341 |
|
| 2017 |
Atif M, Estrada-Mondragon A, Nguyen B, Lynch JW, Keramidas A. Effects of glutamate and ivermectin on single glutamate-gated chloride channels of the parasitic nematode H. contortus. Plos Pathogens. 13: e1006663. PMID 28968469 DOI: 10.1371/Journal.Ppat.1006663 |
0.774 |
|
| 2017 |
Chen X, Durisic N, Lynch JW, Keramidas A. Inhibitory synapse deficits caused by familial α1 GABAA receptor mutations in epilepsy. Neurobiology of Disease. PMID 28870844 DOI: 10.1016/J.Nbd.2017.08.020 |
0.408 |
|
| 2017 |
Chen X, Keramidas A, Lynch JW. Physiological and pharmacological properties of inhibitory postsynaptic currents mediated by α5β1γ2, α5β2γ2 and α5β3γ2 GABAA receptors. Neuropharmacology. PMID 28757051 DOI: 10.1016/J.Neuropharm.2017.07.027 |
0.42 |
|
| 2017 |
Schaefer N, Berger A, van Brederode J, Zheng F, Zhang Y, Leacock S, Littau L, Jablonka S, Malhotra S, Topf M, Winter F, Davydova D, Lynch JW, Paige CJ, Alzheimer C, et al. Disruption of a structurally important extracellular element in the glycine receptor leads to decreased synaptic integration and signaling resulting in severe startle disease. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. PMID 28724750 DOI: 10.1523/Jneurosci.0009-17.2017 |
0.419 |
|
| 2017 |
Dixon CL, Sah P, Keramidas A, Lynch JW, Durisic N. γ1-Containing GABA-A Receptors Cluster at Synapses Where they Mediate Slower Synaptic Currents than γ2-Containing GABA-A Receptors. Frontiers in Molecular Neuroscience. 10: 178. PMID 28642681 DOI: 10.3389/Fnmol.2017.00178 |
0.465 |
|
| 2017 |
Zhang Y, Ho TNT, Harvey RJ, Lynch JW, Keramidas A. Structure-Function Analysis of the GlyR α2 Subunit Autism Mutation p.R323L Reveals a Gain-of-Function. Frontiers in Molecular Neuroscience. 10: 158. PMID 28588452 DOI: 10.3389/Fnmol.2017.00158 |
0.43 |
|
| 2017 |
Lynch JW, Zhang Y, Talwar S, Estrada-Mondragon A. Glycine Receptor Drug Discovery. Advances in Pharmacology (San Diego, Calif.). 79: 225-253. PMID 28528670 DOI: 10.1016/Bs.Apha.2017.01.003 |
0.731 |
|
| 2017 |
Chassagnon IR, McCarthy CA, Chin YK, Pineda SS, Keramidas A, Mobli M, Pham V, De Silva TM, Lynch JW, Widdop RE, Rash LD, King GF. Potent neuroprotection after stroke afforded by a double-knot spider-venom peptide that inhibits acid-sensing ion channel 1a. Proceedings of the National Academy of Sciences of the United States of America. PMID 28320941 DOI: 10.1073/Pnas.1614728114 |
0.319 |
|
| 2017 |
Soh MS, Estrada-Mondragon A, Durisic N, Keramidas A, Lynch JW. Probing the structural mechanism of partial agonism in glycine receptors using the fluorescent artificial amino acid, ANAP. Acs Chemical Biology. PMID 28121133 DOI: 10.1021/Acschembio.6B00926 |
0.762 |
|
| 2016 |
Islam R, Zhang Y, Xu L, Sah P, Lynch JW. A chemogenetic receptor that enhances the magnitude and frequency of glycinergic inhibitory postsynaptic currents without inducing a tonic chloride flux. Acs Chemical Neuroscience. PMID 27958714 DOI: 10.1021/Acschemneuro.6B00382 |
0.417 |
|
| 2016 |
Zhang Y, Keramidas A, Lynch JW. The Free Zinc Concentration in the Synaptic Cleft of Artificial Glycinergic Synapses Rises to At least 1 μM. Frontiers in Molecular Neuroscience. 9: 88. PMID 27713689 DOI: 10.3389/Fnmol.2016.00088 |
0.31 |
|
| 2016 |
Islam R, Keramidas A, Xu L, Durisic N, Sah P, Lynch JW. Ivermectin-activated, cation-permeable glycine receptors for the chemogenetic control of neuronal excitation. Acs Chemical Neuroscience. PMID 27611437 DOI: 10.1021/Acschemneuro.6B00168 |
0.426 |
|
| 2016 |
Zhang Y, Bode A, Nguyen B, Keramidas A, Lynch JW. Investigating the Mechanism by which Gain-of-Function Mutations to the α1 Glycine Receptor cause Hyperekplexia. The Journal of Biological Chemistry. PMID 27226610 DOI: 10.1074/Jbc.M116.728592 |
0.381 |
|
| 2015 |
Dixon CL, Zhang Y, Lynch JW. Generation of Functional Inhibitory Synapses Incorporating Defined Combinations of GABA(A) or Glycine Receptor Subunits. Frontiers in Molecular Neuroscience. 8: 80. PMID 26778954 DOI: 10.3389/Fnmol.2015.00080 |
0.421 |
|
| 2015 |
Estrada-Mondragon A, Lynch JW. Functional characterization of ivermectin binding sites in α1β2γ2L GABA(A) receptors. Frontiers in Molecular Neuroscience. 8: 55. PMID 26441518 DOI: 10.3389/Fnmol.2015.00055 |
0.755 |
|
| 2015 |
Cristofori-Armstrong B, Soh MS, Talwar S, Brown DL, Griffin JD, Dekan Z, Stow JL, King GF, Lynch JW, Rash LD. Xenopus borealis as an alternative source of oocytes for biophysical and pharmacological studies of neuronal ion channels. Scientific Reports. 5: 14763. PMID 26440210 DOI: 10.1038/Srep14763 |
0.375 |
|
| 2015 |
Talwar S, Lynch JW. Investigating ion channel conformational changes using voltage clamp fluorometry. Neuropharmacology. PMID 25839896 DOI: 10.1016/J.Neuropharm.2015.03.018 |
0.414 |
|
| 2015 |
Dixon CL, Harrison NL, Lynch JW, Keramidas A. Zolpidem and eszopiclone prime α1β2γ2 GABAA receptors for longer duration of activity. British Journal of Pharmacology. 172: 3522-36. PMID 25817320 DOI: 10.1111/Bph.13142 |
0.427 |
|
| 2015 |
Soh MS, Lynch JW. Selective Modulators of α5-Containing GABAA Receptors and their Therapeutic Significance. Current Drug Targets. 16: 735-46. PMID 25751008 DOI: 10.2174/1389450116666150309120235 |
0.407 |
|
| 2015 |
Benson MJ, Thomas NK, Talwar S, Hodson MP, Lynch JW, Woodruff TM, Borges K. A novel anticonvulsant mechanism via inhibition of complement receptor C5ar1 in murine epilepsy models. Neurobiology of Disease. 76: 87-97. PMID 25681535 DOI: 10.1016/J.Nbd.2015.02.004 |
0.324 |
|
| 2015 |
Scott S, Lynch JW, Keramidas A. Correlating structural and energetic changes in glycine receptor activation. The Journal of Biological Chemistry. 290: 5621-34. PMID 25572390 DOI: 10.1074/Jbc.M114.616573 |
0.503 |
|
| 2015 |
Zhang Y, Dixon CL, Keramidas A, Lynch JW. Functional reconstitution of glycinergic synapses incorporating defined glycine receptor subunit combinations. Neuropharmacology. 89: 391-7. PMID 25445488 DOI: 10.1016/J.Neuropharm.2014.10.026 |
0.435 |
|
| 2014 |
Ulens C, Spurny R, Thompson AJ, Alqazzaz M, Debaveye S, Han L, Price K, Villalgordo JM, Tresadern G, Lynch JW, Lummis SC. The prokaryote ligand-gated ion channel ELIC captured in a pore blocker-bound conformation by the Alzheimer's disease drug memantine. Structure (London, England : 1993). 22: 1399-407. PMID 25199693 DOI: 10.1016/J.Str.2014.07.013 |
0.419 |
|
| 2014 |
Talwar S, Lynch JW. Phosphorylation mediated structural and functional changes in pentameric ligand-gated ion channels: Implications for drug discovery International Journal of Biochemistry and Cell Biology. 53: 218-233. PMID 24880089 DOI: 10.1016/J.Biocel.2014.05.028 |
0.43 |
|
| 2014 |
Dixon C, Sah P, Lynch JW, Keramidas A. GABAA receptor α and γ subunits shape synaptic currents via different mechanisms. The Journal of Biological Chemistry. 289: 5399-411. PMID 24425869 DOI: 10.1074/Jbc.M113.514695 |
0.435 |
|
| 2014 |
Bode A, Lynch JW. The impact of human hyperekplexia mutations on glycine receptor structure and function. Molecular Brain. 7: 2. PMID 24405574 DOI: 10.1186/1756-6606-7-2 |
0.387 |
|
| 2013 |
Alexander SP, Benson HE, Faccenda E, Pawson AJ, Sharman JL, McGrath JC, Catterall WA, Spedding M, Peters JA, Harmar AJ, Abul-Hasn N, Anderson CM, Anderson CM, Araiksinen MS, ... ... Lynch JW, et al. The Concise Guide to PHARMACOLOGY 2013/14: overview. British Journal of Pharmacology. 170: 1449-58. PMID 24528237 DOI: 10.1111/Bph.12444 |
0.312 |
|
| 2013 |
Bode A, Wood SE, Mullins JG, Keramidas A, Cushion TD, Thomas RH, Pickrell WO, Drew CJ, Masri A, Jones EA, Vassallo G, Born AP, Alehan F, Aharoni S, Bannasch G, ... ... Lynch JW, et al. New hyperekplexia mutations provide insight into glycine receptor assembly, trafficking, and activation mechanisms. The Journal of Biological Chemistry. 288: 33745-59. PMID 24108130 DOI: 10.1074/Jbc.M113.509240 |
0.449 |
|
| 2013 |
Bode A, Lynch JW. Analysis of hyperekplexia mutations identifies transmembrane domain rearrangements that mediate glycine receptor activation. The Journal of Biological Chemistry. 288: 33760-71. PMID 24097980 DOI: 10.1074/Jbc.M113.513804 |
0.503 |
|
| 2013 |
Han L, Talwar S, Wang Q, Shan Q, Lynch JW. Phosphorylation of α3 glycine receptors induces a conformational change in the glycine-binding site. Acs Chemical Neuroscience. 4: 1361-70. PMID 23834509 DOI: 10.1021/Cn400097J |
0.454 |
|
| 2013 |
Balansa W, Islam R, Fontaine F, Piggott AM, Zhang H, Xiao X, Webb TI, Gilbert DF, Lynch JW, Capon RJ. Sesterterpene glycinyl-lactams: a new class of glycine receptor modulator from Australian marine sponges of the genus Psammocinia. Organic & Biomolecular Chemistry. 11: 4695-701. PMID 23760172 DOI: 10.1039/C3Ob40861B |
0.438 |
|
| 2013 |
Balansa W, Islam R, Gilbert DF, Fontaine F, Xiao X, Zhang H, Piggott AM, Lynch JW, Capon RJ. Australian marine sponge alkaloids as a new class of glycine-gated chloride channel receptor modulator. Bioorganic & Medicinal Chemistry. 21: 4420-5. PMID 23685178 DOI: 10.1016/J.Bmc.2013.04.061 |
0.422 |
|
| 2013 |
Talwar S, Lynch JW, Gilbert DF. Fluorescence-based high-throughput functional profiling of ligand-gated ion channels at the level of single cells. Plos One. 8: e58479. PMID 23520514 DOI: 10.1371/Journal.Pone.0058479 |
0.441 |
|
| 2013 |
Han L, Talwar S, Lynch JW. The relative orientation of the TM3 and TM4 domains varies between α1 and α3 glycine receptors Acs Chemical Neuroscience. 4: 248-254. PMID 23421675 DOI: 10.1021/Cn300177G |
0.413 |
|
| 2013 |
James VM, Bode A, Chung SK, Gill JL, Nielsen M, Cowan FM, Vujic M, Thomas RH, Rees MI, Harvey K, Keramidas A, Topf M, Ginjaar I, Lynch JW, Harvey RJ. Novel missense mutations in the glycine receptor β subunit gene (GLRB) in startle disease. Neurobiology of Disease. 52: 137-49. PMID 23238346 DOI: 10.1016/J.Nbd.2012.12.001 |
0.389 |
|
| 2013 |
Chung SK, Bode A, Cushion TD, Thomas RH, Hunt C, Wood SE, Pickrell WO, Drew CJ, Yamashita S, Shiang R, Leiz S, Longardt AC, Longhardt AC, Raile V, Weschke B, ... ... Lynch JW, et al. GLRB is the third major gene of effect in hyperekplexia. Human Molecular Genetics. 22: 927-40. PMID 23184146 DOI: 10.1093/Hmg/Dds498 |
0.376 |
|
| 2013 |
Keramidas A, Lynch JW. An outline of desensitization in pentameric ligand-gated ion channel receptors. Cellular and Molecular Life Sciences : Cmls. 70: 1241-53. PMID 22936353 DOI: 10.1007/S00018-012-1133-Z |
0.501 |
|
| 2012 |
Yang Z, Taran E, Webb TI, Lynch JW. Stoichiometry and subunit arrangement of α1β glycine receptors as determined by atomic force microscopy. Biochemistry. 51: 5229-31. PMID 22715885 DOI: 10.1021/Bi300063M |
0.431 |
|
| 2012 |
Lynagh T, Lynch JW. Ivermectin binding sites in human and invertebrate Cys-loop receptors. Trends in Pharmacological Sciences. 33: 432-41. PMID 22677714 DOI: 10.1016/J.Tips.2012.05.002 |
0.457 |
|
| 2012 |
Lynagh T, Lynch JW. Molecular mechanisms of Cys-loop ion channel receptor modulation by ivermectin. Frontiers in Molecular Neuroscience. 5: 60. PMID 22586367 DOI: 10.3389/Fnmol.2012.00060 |
0.564 |
|
| 2012 |
Shan Q, Han L, Lynch JW. Distinct properties of glycine receptor β+/α- interface: unambiguously characterizing heteromeric interface reconstituted in homomeric protein. The Journal of Biological Chemistry. 287: 21244-52. PMID 22535951 DOI: 10.1074/Jbc.M111.337741 |
0.355 |
|
| 2012 |
Shan Q, Lynch JW. Incompatibility between a pair of residues from the pre-M1 linker and Cys-loop blocks surface expression of the glycine receptor. The Journal of Biological Chemistry. 287: 7535-42. PMID 22267740 DOI: 10.1074/Jbc.M111.325126 |
0.453 |
|
| 2012 |
Wang Q, Lynch JW. A comparison of glycine- and ivermectin-mediated conformational changes in the glycine receptor ligand-binding domain. The International Journal of Biochemistry & Cell Biology. 44: 335-40. PMID 22094187 DOI: 10.1016/J.Biocel.2011.11.005 |
0.459 |
|
| 2012 |
Islam R, Lynch JW. Mechanism of action of the insecticides, lindane and fipronil, on glycine receptor chloride channels. British Journal of Pharmacology. 165: 2707-20. PMID 22035056 DOI: 10.1111/J.1476-5381.2011.01722.X |
0.506 |
|
| 2012 |
Shan Q, Han L, Lynch JW. Function of hyperekplexia-causing α1R271Q/L glycine receptors is restored by shifting the affected residue out of the allosteric signalling pathway. British Journal of Pharmacology. 165: 2113-23. PMID 21955162 DOI: 10.1111/J.1476-5381.2011.01701.X |
0.466 |
|
| 2011 |
Shan Q, Han L, Lynch JW. β Subunit M2-M3 loop conformational changes are uncoupled from α1 β glycine receptor channel gating: implications for human hereditary hyperekplexia. Plos One. 6: e28105. PMID 22132222 DOI: 10.1371/Journal.Pone.0028105 |
0.402 |
|
| 2011 |
Lynagh T, Webb TI, Dixon CL, Cromer BA, Lynch JW. Molecular determinants of ivermectin sensitivity at the glycine receptor chloride channel. The Journal of Biological Chemistry. 286: 43913-24. PMID 22033924 DOI: 10.1074/Jbc.M111.262634 |
0.497 |
|
| 2011 |
Wang Q, Lynch JW. Activation and desensitization induce distinct conformational changes at the extracellular-transmembrane domain interface of the glycine receptor. The Journal of Biological Chemistry. 286: 38814-24. PMID 21917927 DOI: 10.1074/Jbc.M111.273631 |
0.496 |
|
| 2011 |
Pless SA, Hanek AP, Price KL, Lynch JW, Lester HA, Dougherty DA, Lummis SC. A cation-π interaction at a phenylalanine residue in the glycine receptor binding site is conserved for different agonists. Molecular Pharmacology. 79: 742-8. PMID 21266487 DOI: 10.1124/Mol.110.069583 |
0.428 |
|
| 2010 |
Wang Q, Pless SA, Lynch JW. Ligand- and subunit-specific conformational changes in the ligand-binding domain and the TM2-TM3 linker of {alpha}1 {beta}2 {gamma}2 GABAA receptors. The Journal of Biological Chemistry. 285: 40373-86. PMID 20937799 DOI: 10.1074/Jbc.M110.161513 |
0.476 |
|
| 2010 |
Lynagh T, Lynch JW. A glycine residue essential for high ivermectin sensitivity in Cys-loop ion channel receptors. International Journal For Parasitology. 40: 1477-81. PMID 20713056 DOI: 10.1016/J.Ijpara.2010.07.010 |
0.482 |
|
| 2010 |
Chung SK, Vanbellinghen JF, Mullins JG, Robinson A, Hantke J, Hammond CL, Gilbert DF, Freilinger M, Ryan M, Kruer MC, Masri A, Gurses C, Ferrie C, Harvey K, Shiang R, ... ... Lynch JW, et al. Pathophysiological mechanisms of dominant and recessive GLRA1 mutations in hyperekplexia. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 30: 9612-20. PMID 20631190 DOI: 10.1523/Jneurosci.1763-10.2010 |
0.423 |
|
| 2010 |
Balansa W, Islam R, Fontaine F, Piggott AM, Zhang H, Webb TI, Gilbert DF, Lynch JW, Capon RJ. Ircinialactams: subunit-selective glycine receptor modulators from Australian sponges of the family Irciniidae. Bioorganic & Medicinal Chemistry. 18: 2912-9. PMID 20346682 DOI: 10.1016/J.Bmc.2010.03.002 |
0.431 |
|
| 2010 |
Lynagh T, Lynch JW. An improved ivermectin-activated chloride channel receptor for inhibiting electrical activity in defined neuronal populations. The Journal of Biological Chemistry. 285: 14890-7. PMID 20308070 DOI: 10.1074/Jbc.M110.107789 |
0.468 |
|
| 2010 |
Delaney AJ, Esmaeili A, Sedlak PL, Lynch JW, Sah P. Differential expression of glycine receptor subunits in the rat basolateral and central amygdala. Neuroscience Letters. 469: 237-42. PMID 19995593 DOI: 10.1016/J.Neulet.2009.12.003 |
0.374 |
|
| 2009 |
Gilbert DF, Islam R, Lynagh T, Lynch JW, Webb TI. High Throughput Techniques for Discovering New Glycine Receptor Modulators and their Binding Sites. Frontiers in Molecular Neuroscience. 2: 17. PMID 19949449 DOI: 10.3389/Neuro.02.017.2009 |
0.445 |
|
| 2009 |
Pless SA, Lynch JW. Magnitude of a conformational change in the glycine receptor beta1-beta2 loop is correlated with agonist efficacy. The Journal of Biological Chemistry. 284: 27370-6. PMID 19643731 DOI: 10.1074/Jbc.M109.048405 |
0.451 |
|
| 2009 |
Chen X, Webb TI, Lynch JW. The M4 transmembrane segment contributes to agonist efficacy differences between alpha1 and alpha3 glycine receptors. Molecular Membrane Biology. 26: 321-32. PMID 19626554 DOI: 10.1080/09687680903120319 |
0.372 |
|
| 2009 |
Chen X, Cromer BA, Lynch JW. Molecular determinants of beta-carboline inhibition of the glycine receptor. Journal of Neurochemistry. 110: 1685-94. PMID 19619142 DOI: 10.1111/J.1471-4159.2009.06273.X |
0.446 |
|
| 2009 |
Pless SA, Lynch JW. Ligand-specific conformational changes in the alpha1 glycine receptor ligand-binding domain. The Journal of Biological Chemistry. 284: 15847-56. PMID 19286654 DOI: 10.1074/Jbc.M809343200 |
0.469 |
|
| 2009 |
Gilbert DF, Wilson JC, Nink V, Lynch JW, Osborne GW. Multiplexed labeling of viable cells for high-throughput analysis of glycine receptor function using flow cytometry. Cytometry. Part a : the Journal of the International Society For Analytical Cytology. 75: 440-9. PMID 19184990 DOI: 10.1002/Cyto.A.20703 |
0.389 |
|
| 2009 |
Gilbert D, Esmaeili A, Lynch JW. Optimizing the expression of recombinant alphabetagamma GABAA receptors in HEK293 cells for high-throughput screening. Journal of Biomolecular Screening. 14: 86-91. PMID 19171924 DOI: 10.1177/1087057108328017 |
0.349 |
|
| 2009 |
Pless SA, Lynch JW. Distinct conformational changes in activated agonist-bound and agonist-free glycine receptor subunits. Journal of Neurochemistry. 108: 1585-94. PMID 19166513 DOI: 10.1111/J.1471-4159.2009.05930.X |
0.484 |
|
| 2009 |
Esmaeili A, Lynch JW, Sah P. GABAA receptors containing gamma1 subunits contribute to inhibitory transmission in the central amygdala. Journal of Neurophysiology. 101: 341-9. PMID 19004994 DOI: 10.1152/Jn.90991.2008 |
0.443 |
|
| 2009 |
Lynch JW. Native glycine receptor subtypes and their physiological roles. Neuropharmacology. 56: 303-9. PMID 18721822 DOI: 10.1016/J.Neuropharm.2008.07.034 |
0.413 |
|
| 2009 |
Chen X, Cromer B, Webb TI, Yang Z, Hantke J, Harvey RJ, Parker MW, Lynch JW. Dihydropyridine inhibition of the glycine receptor: subunit selectivity and a molecular determinant of inhibition. Neuropharmacology. 56: 318-27. PMID 18657556 DOI: 10.1016/J.Neuropharm.2008.07.001 |
0.427 |
|
| 2008 |
Pless SA, Millen KS, Hanek AP, Lynch JW, Lester HA, Lummis SC, Dougherty DA. A cation-pi interaction in the binding site of the glycine receptor is mediated by a phenylalanine residue. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 28: 10937-42. PMID 18945901 DOI: 10.1523/Jneurosci.2540-08.2008 |
0.438 |
|
| 2008 |
Yang Z, Aubrey KR, Alroy I, Harvey RJ, Vandenberg RJ, Lynch JW. Subunit-specific modulation of glycine receptors by cannabinoids and N-arachidonyl-glycine. Biochemical Pharmacology. 76: 1014-23. PMID 18755158 DOI: 10.1016/J.Bcp.2008.07.037 |
0.353 |
|
| 2008 |
Pless SA, Lynch JW. Illuminating the structure and function of Cys-loop receptors. Clinical and Experimental Pharmacology & Physiology. 35: 1137-42. PMID 18505452 DOI: 10.1111/J.1440-1681.2008.04954.X |
0.502 |
|
| 2008 |
Lynch JW, Chen X. Subunit-specific potentiation of recombinant glycine receptors by NV-31, a bilobalide-derived compound. Neuroscience Letters. 435: 147-51. PMID 18329806 DOI: 10.1016/J.Neulet.2008.02.022 |
0.439 |
|
| 2008 |
Heads JA, Hawthorne RL, Lynagh T, Lynch JW. Structure-activity analysis of ginkgolide binding in the glycine receptor pore. Journal of Neurochemistry. 105: 1418-27. PMID 18221374 DOI: 10.1111/J.1471-4159.2008.05244.X |
0.422 |
|
| 2007 |
Pless SA, Dibas MI, Lester HA, Lynch JW. Conformational variability of the glycine receptor M2 domain in response to activation by different agonists. The Journal of Biological Chemistry. 282: 36057-67. PMID 17911099 DOI: 10.1074/Jbc.M706468200 |
0.456 |
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| 2007 |
Yang Z, Cromer BA, Harvey RJ, Parker MW, Lynch JW. A proposed structural basis for picrotoxinin and picrotin binding in the glycine receptor pore. Journal of Neurochemistry. 103: 580-9. PMID 17714449 DOI: 10.1111/J.1471-4159.2007.04850.X |
0.388 |
|
| 2007 |
Webb TI, Lynch JW. Molecular pharmacology of the glycine receptor chloride channel. Current Pharmaceutical Design. 13: 2350-67. PMID 17692006 DOI: 10.2174/138161207781368693 |
0.484 |
|
| 2007 |
Yang Z, Webb TI, Lynch JW. Closed-state cross-linking of adjacent beta1 subunits in alpha1beta1 GABAa receptors via introduced 6' cysteines. The Journal of Biological Chemistry. 282: 16803-10. PMID 17405880 DOI: 10.1074/Jbc.M611555200 |
0.387 |
|
| 2007 |
Yang Z, Ney A, Cromer BA, Ng HL, Parker MW, Lynch JW. Tropisetron modulation of the glycine receptor: femtomolar potentiation and a molecular determinant of inhibition. Journal of Neurochemistry. 100: 758-69. PMID 17181559 DOI: 10.1111/J.1471-4159.2006.04242.X |
0.502 |
|
| 2006 |
Hawthorne R, Cromer BA, Ng HL, Parker MW, Lynch JW. Molecular determinants of ginkgolide binding in the glycine receptor pore. Journal of Neurochemistry. 98: 395-407. PMID 16805834 DOI: 10.1111/J.1471-4159.2006.03875.X |
0.396 |
|
| 2005 |
Hawthorne R, Lynch JW. A picrotoxin-specific conformational change in the glycine receptor M2-M3 loop. The Journal of Biological Chemistry. 280: 35836-43. PMID 16109711 DOI: 10.1074/Jbc.M506645200 |
0.439 |
|
| 2005 |
Kruger W, Gilbert D, Hawthorne R, Hryciw DH, Frings S, Poronnik P, Lynch JW. A yellow fluorescent protein-based assay for high-throughput screening of glycine and GABAA receptor chloride channels Neuroscience Letters. 380: 340-345. PMID 15862914 DOI: 10.1016/J.Neulet.2005.01.065 |
0.43 |
|
| 2005 |
Barry PH, Lynch JW. Ligand-gated channels. Ieee Transactions On Nanobioscience. 4: 70-80. PMID 15816173 DOI: 10.1109/Tnb.2004.842497 |
0.464 |
|
| 2005 |
Lynch J. High-Throughput Screening of Neuronal Cl- Channels: Why and How? Current Neuropharmacology. 3: 207-216. DOI: 10.2174/1570159054368286 |
0.443 |
|
| 2004 |
Lynch JW. Molecular structure and function of the glycine receptor chloride channel. Physiological Reviews. 84: 1051-95. PMID 15383648 DOI: 10.1152/Physrev.00042.2003 |
0.488 |
|
| 2004 |
Han NL, Clements JD, Lynch JW. Comparison of taurine- and glycine-induced conformational changes in the M2-M3 domain of the glycine receptor. The Journal of Biological Chemistry. 279: 19559-65. PMID 14981077 DOI: 10.1074/Jbc.M400548200 |
0.485 |
|
| 2003 |
Shan Q, Nevin ST, Haddrill JL, Lynch JW. Asymmetric contribution of alpha and beta subunits to the activation of alphabeta heteromeric glycine receptors. Journal of Neurochemistry. 86: 498-507. PMID 12871591 DOI: 10.1046/J.1471-4159.2003.01872.X |
0.416 |
|
| 2003 |
Nevin ST, Cromer BA, Haddrill JL, Morton CJ, Parker MW, Lynch JW. Insights into the structural basis for zinc inhibition of the glycine receptor Journal of Biological Chemistry. 278: 28985-28992. PMID 12740384 DOI: 10.1074/Jbc.M300097200 |
0.46 |
|
| 2002 |
Seebungkert B, Lynch JW. Effects of polyunsaturated fatty acids on voltage-gated K+ and Na+ channels in rat olfactory receptor neurons. The European Journal of Neuroscience. 16: 2085-94. PMID 12473076 DOI: 10.1046/J.1460-9568.2002.02288.X |
0.401 |
|
| 2002 |
Shan Q, Haddrill JL, Lynch JW. Comparative surface accessibility of a pore-lining threonine residue (T6') in the glycine and GABA(A) receptors. The Journal of Biological Chemistry. 277: 44845-53. PMID 12239220 DOI: 10.1074/Jbc.M208647200 |
0.468 |
|
| 2001 |
Han NL, Haddrill JL, Lynch JW. Characterization of a glycine receptor domain that controls the binding and gating mechanisms of the beta-amino acid agonist, taurine. Journal of Neurochemistry. 79: 636-47. PMID 11701767 DOI: 10.1046/J.1471-4159.2001.00601.X |
0.463 |
|
| 2001 |
Seebungkert B, Lynch JW. A common inhibitory binding site for zinc and odorants at the voltage-gated K(+) channel of rat olfactory receptor neurons. The European Journal of Neuroscience. 14: 353-62. PMID 11553285 DOI: 10.1046/J.0953-816X.2001.01646.X |
0.406 |
|
| 2001 |
Lynch JW, Han NL, Haddrill J, Pierce KD, Schofield PR. The surface accessibility of the glycine receptor M2-M3 loop is increased in the channel open state. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 21: 2589-99. PMID 11306612 DOI: 10.1523/Jneurosci.21-08-02589.2001 |
0.404 |
|
| 2001 |
Shan Q, Haddrill JL, Lynch JW. Ivermectin, an unconventional agonist of the glycine receptor chloride channel. The Journal of Biological Chemistry. 276: 12556-64. PMID 11278873 DOI: 10.1074/Jbc.M011264200 |
0.478 |
|
| 2001 |
Shan Q, Haddrill JL, Lynch JW. A single beta subunit M2 domain residue controls the picrotoxin sensitivity of alphabeta heteromeric glycine receptor chloride channels. Journal of Neurochemistry. 76: 1109-20. PMID 11181831 DOI: 10.1046/J.1471-4159.2001.00124.X |
0.47 |
|
| 2001 |
Nevin ST, Haddrill JL, Lynch JW. A pore-lining glutamic acid in the rat olfactory cyclic nucleotide-gated channel controls external spermine block. Neuroscience Letters. 296: 163-7. PMID 11109006 DOI: 10.1016/S0304-3940(00)01650-5 |
0.446 |
|
| 2001 |
Lynch JW, Han NR, Haddrill J, Pierce KD, Schofield PR. The Surface Accessibility of the Glycine Receptor M2–M3 Loop Is Increased in the Channel Open State The Journal of Neuroscience. 21: 2589-2599. DOI: 10.1523/JNEUROSCI.21-08-02589.2001 |
0.324 |
|
| 1999 |
Lynch JW, Han NI, Schofield PR. Building new function into glycine receptors: a structural model for the activation of the glycine-gated chloride channel. Clinical and Experimental Pharmacology & Physiology. 26: 932-4. PMID 10561818 DOI: 10.1046/J.1440-1681.1999.03150.X |
0.486 |
|
| 1999 |
Lynch JW. Rectification of the olfactory cyclic nucleotide-gated channel by intracellular polyamines. The Journal of Membrane Biology. 170: 213-27. PMID 10441665 DOI: 10.1007/S002329900551 |
0.415 |
|
| 1999 |
Barry PH, Chiu P, Lynch JW. An analysis of odorant-induced currents in on-cell patches on mammalian olfactory receptor neurons. Annals of the New York Academy of Sciences. 855: 208-11. PMID 9929607 DOI: 10.1111/J.1749-6632.1998.Tb10568.X |
0.353 |
|
| 1998 |
Lynch JW, Jacques P, Pierce KD, Schofield PR. Zinc potentiation of the glycine receptor chloride channel is mediated by allosteric pathways. Journal of Neurochemistry. 71: 2159-68. PMID 9798943 DOI: 10.1046/J.1471-4159.1998.71052159.X |
0.474 |
|
| 1998 |
Lynch JW. Nitric oxide inhibition of the rat olfactory cyclic nucleotide-gated cation channel. The Journal of Membrane Biology. 165: 227-34. PMID 9767676 DOI: 10.1007/S002329900436 |
0.446 |
|
| 1998 |
Hallani M, Lynch JW, Barry PH. Characterization of calcium-activated chloride channels in patches excised from the dendritic knob of mammalian olfactory receptor neurons. The Journal of Membrane Biology. 161: 163-71. PMID 9435272 DOI: 10.1007/S002329900323 |
0.428 |
|
| 1997 |
Balasubramanian S, Lynch JW, Barry PH. Concentration dependence of sodium permeation and sodium ion interactions in the cyclic AMP-gated channels of mammalian olfactory receptor neurons. The Journal of Membrane Biology. 159: 41-52. PMID 9309209 DOI: 10.1007/S002329900267 |
0.433 |
|
| 1997 |
Chiu P, Lynch JW, Barry PH. Odorant-induced currents in intact patches from rat olfactory receptor neurons: theory and experiment. Biophysical Journal. 72: 1442-57. PMID 9138590 DOI: 10.1016/S0006-3495(97)78791-5 |
0.342 |
|
| 1997 |
Rajendra S, Lynch JW, Schofield PR. The glycine receptor. Pharmacology & Therapeutics. 73: 121-46. PMID 9131721 DOI: 10.1016/S0163-7258(96)00163-5 |
0.482 |
|
| 1997 |
Lynch JW, Rajendra S, Pierce KD, Handford CA, Barry PH, Schofield PR. Identification of intracellular and extracellular domains mediating signal transduction in the inhibitory glycine receptor chloride channel. The Embo Journal. 16: 110-20. PMID 9009272 DOI: 10.1093/Emboj/16.1.110 |
0.462 |
|
| 1996 |
Schofield PR, Lynch JW, Rajendra S, Pierce KD, Handford CA, Barry PH. Molecular and genetic insights into ligand binding and signal transduction at the inhibitory glycine receptor. Cold Spring Harbor Symposia On Quantitative Biology. 61: 333-42. PMID 9246463 DOI: 10.1101/Sqb.1996.061.01.037 |
0.382 |
|
| 1996 |
Handford CA, Lynch JW, Baker E, Webb GC, Ford JH, Sutherland GR, Schofield PR. The human glycine receptor beta subunit: primary structure, functional characterisation and chromosomal localisation of the human and murine genes. Brain Research. Molecular Brain Research. 35: 211-9. PMID 8717357 DOI: 10.1016/0169-328X(95)00218-H |
0.343 |
|
| 1996 |
Balasubramanian S, Lynch JW, Barry PH. Calcium-dependent modulation of the agonist affinity of the mammalian olfactory cyclic nucleotide-gated channel by calmodulin and a novel endogenous factor. The Journal of Membrane Biology. 152: 13-23. PMID 8660407 DOI: 10.1007/S002329900081 |
0.365 |
|
| 1995 |
Rajendra S, Lynch JW, Pierce KD, French CR, Barry PH, Schofield PR. Mutation of an arginine residue in the human glycine receptor transforms beta-alanine and taurine from agonists into competitive antagonists. Neuron. 14: 169-75. PMID 7826634 DOI: 10.1016/0896-6273(95)90251-1 |
0.516 |
|
| 1995 |
Lynch JW, Rajendra S, Barry PH, Schofield PR. Mutations affecting the glycine receptor agonist transduction mechanism convert the competitive antagonist, picrotoxin, into an allosteric potentiator. The Journal of Biological Chemistry. 270: 13799-806. PMID 7775436 DOI: 10.1074/Jbc.270.23.13799 |
0.53 |
|
| 1995 |
Balasubramanian S, Lynch JW, Barry PH. The permeation of organic cations through cAMP-gated channels in mammalian olfactory receptor neurons. The Journal of Membrane Biology. 146: 177-91. PMID 7473687 DOI: 10.1007/Bf00238007 |
0.428 |
|
| 1994 |
Ryan SG, Buckwalter MS, Lynch JW, Handford CA, Segura L, Shiang R, Wasmuth JJ, Camper SA, Schofield P, O'Connell P. A missense mutation in the gene encoding the alpha 1 subunit of the inhibitory glycine receptor in the spasmodic mouse. Nature Genetics. 7: 131-5. PMID 7920629 DOI: 10.1038/Ng0694-131 |
0.384 |
|
| 1994 |
Lynch JW, Lindemann B. Cyclic nucleotide-gated channels of rat olfactory receptor cells: divalent cations control the sensitivity to cAMP. The Journal of General Physiology. 103: 87-106. PMID 7513349 DOI: 10.1085/Jgp.103.1.87 |
0.415 |
|
| 1992 |
Frings S, Lynch JW, Lindemann B. Properties of cyclic nucleotide-gated channels mediating olfactory transduction. Activation, selectivity, and blockage. The Journal of General Physiology. 100: 45-67. PMID 1324972 DOI: 10.1085/Jgp.100.1.45 |
0.47 |
|
| 1992 |
Rajendra S, Lynch JW, Barry PH. An analysis of Na+ currents in rat olfactory receptor neurons. Pflugers Archiv : European Journal of Physiology. 420: 342-6. PMID 1317952 DOI: 10.1007/Bf00374468 |
0.351 |
|
| 1991 |
Lynch JW, Barry PH. Properties of transient K+ currents and underlying single K+ channels in rat olfactory receptor neurons. The Journal of General Physiology. 97: 1043-72. PMID 1865174 DOI: 10.1085/Jgp.97.5.1043 |
0.37 |
|
| 1991 |
Barry PH, Lynch JW. Liquid junction potentials and small cell effects in patch-clamp analysis. The Journal of Membrane Biology. 121: 101-17. PMID 1715403 DOI: 10.1007/Bf01870526 |
0.349 |
|
| 1991 |
Lynch JW, Barry PH. Slowly activating K+ channels in rat olfactory receptor neurons. Proceedings. Biological Sciences. 244: 219-25. PMID 1679941 DOI: 10.1098/Rspb.1991.0074 |
0.432 |
|
| 1991 |
Lynch JW, Barry PH. Inward rectification in rat olfactory receptor neurons. Proceedings. Biological Sciences. 243: 149-53. PMID 1676518 DOI: 10.1098/Rspb.1991.0024 |
0.324 |
|
| 1989 |
Lynch JW, Barry PH. Action potentials initiated by single channels opening in a small neuron (rat olfactory receptor). Biophysical Journal. 55: 755-68. PMID 2470428 DOI: 10.1016/S0006-3495(89)82874-7 |
0.404 |
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