Darrell J Irvine - Publications

Affiliations: 
Department of Biological Engineering Massachusetts Institute of Technology, Cambridge, MA, United States 

55 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2016 Steichen JM, Kulp DW, Tokatlian T, Escolano A, Dosenovic P, Stanfield RL, McCoy LE, Ozorowski G, Hu X, Kalyuzhniy O, Briney B, Schiffner T, Garces F, Freund NT, Gitlin AD, ... ... Irvine DJ, et al. HIV Vaccine Design to Target Germline Precursors of Glycan-Dependent Broadly Neutralizing Antibodies. Immunity. PMID 27617678 DOI: 10.1016/j.immuni.2016.08.016  0.52
2016 Jones RB, Mueller S, O'Connor R, Rimpel K, Sloan DD, Karel D, Wong HC, Jeng EK, Thomas AS, Whitney JB, Lim SY, Kovacs C, Benko E, Karandish S, Huang SH, ... ... Irvine DJ, et al. A Subset of Latency-Reversing Agents Expose HIV-Infected Resting CD4+ T-Cells to Recognition by Cytotoxic T-Lymphocytes. Plos Pathogens. 12: e1005545. PMID 27082643 DOI: 10.1371/journal.ppat.1005545  0.52
2016 Moyer TJ, Zmolek AC, Irvine DJ. Beyond antigens and adjuvants: formulating future vaccines. The Journal of Clinical Investigation. 126: 799-808. PMID 26928033 DOI: 10.1172/JCI81083  0.52
2016 Irvine DJ. A Receptor for All Occasions Cell. 164: 599-600. PMID 26871625 DOI: 10.1016/j.cell.2016.01.030  0.52
2015 Dane EL, Irvine DJ. Big thinking for adjuvants Nature Biotechnology. 33: 1146-1148. PMID 26544144 DOI: 10.1038/nbt.3398  0.52
2015 Hotaling NA, Tang L, Irvine DJ, Babensee JE. Biomaterial Strategies for Immunomodulation. Annual Review of Biomedical Engineering. PMID 26421896 DOI: 10.1146/annurev-bioeng-071813-104814  0.52
2015 Mehta NK, Moynihan KD, Irvine DJ. Engineering New Approaches to Cancer Vaccines. Cancer Immunology Research. 3: 836-43. PMID 26156157 DOI: 10.1158/2326-6066.CIR-15-0112  0.52
2015 Irvine DJ, Hanson MC, Rakhra K, Tokatlian T. Synthetic Nanoparticles for Vaccines and Immunotherapy. Chemical Reviews. 115: 11109-46. PMID 26154342 DOI: 10.1021/acs.chemrev.5b00109  0.52
2015 Atukorale PU, Yang YS, Bekdemir A, Carney RP, Silva PJ, Watson N, Stellacci F, Irvine DJ. Influence of the glycocalyx and plasma membrane composition on amphiphilic gold nanoparticle association with erythrocytes. Nanoscale. 7: 11420-11432. PMID 26077112 DOI: 10.1039/c5nr01355k  0.52
2015 Huang B, Abraham WD, Zheng Y, Bustamante López SC, Luo SS, Irvine DJ. Active targeting of chemotherapy to disseminated tumors using nanoparticle-carrying T cells. Science Translational Medicine. 7: 291ra94. PMID 26062846 DOI: 10.1126/scitranslmed.aaa5447  0.52
2015 Lee Szeto G, Van Egeren D, Worku H, Sharei A, Alejandro B, Park C, Frew K, Brefo M, Mao S, Heimann M, Langer R, Jensen K, Irvine DJ. Microfluidic squeezing for intracellular antigen loading in polyclonal B-cells as cellular vaccines. Scientific Reports. 5: 10276. PMID 25999171 DOI: 10.1038/srep10276  0.52
2015 Hanson MC, Crespo MP, Abraham W, Moynihan KD, Szeto GL, Chen SH, Melo MB, Mueller S, Irvine DJ. Nanoparticulate STING agonists are potent lymph node-targeted vaccine adjuvants. The Journal of Clinical Investigation. 125: 2532-46. PMID 25938786 DOI: 10.1172/JCI79915  0.52
2015 Liu H, Irvine DJ. Guiding principles in the design of molecular bioconjugates for vaccine applications. Bioconjugate Chemistry. 26: 791-801. PMID 25822926 DOI: 10.1021/acs.bioconjchem.5b00103  0.52
2015 Hanson MC, Abraham W, Crespo MP, Chen SH, Liu H, Szeto GL, Kim M, Reinherz EL, Irvine DJ. Liposomal vaccines incorporating molecular adjuvants and intrastructural T-cell help promote the immunogenicity of HIV membrane-proximal external region peptides. Vaccine. 33: 861-8. PMID 25559188 DOI: 10.1016/j.vaccine.2014.12.045  0.52
2014 Yang YS, Carney RP, Stellacci F, Irvine DJ. Enhancing radiotherapy by lipid nanocapsule-mediated delivery of amphiphilic gold nanoparticles to intracellular membranes. Acs Nano. 8: 8992-9002. PMID 25123510 DOI: 10.1021/nn502146r  0.52
2014 Jones RB, O'Connor R, Mueller S, Foley M, Szeto GL, Karel D, Lichterfeld M, Kovacs C, Ostrowski MA, Trocha A, Irvine DJ, Walker BD. Histone deacetylase inhibitors impair the elimination of HIV-infected cells by cytotoxic T-lymphocytes. Plos Pathogens. 10: e1004287. PMID 25122219 DOI: 10.1371/journal.ppat.1004287  0.52
2014 Hanson MC, Bershteyn A, Crespo MP, Irvine DJ. Antigen delivery by lipid-enveloped PLGA microparticle vaccines mediated by in situ vesicle shedding Biomacromolecules. 15: 2475-2481. PMID 24894061 DOI: 10.1021/bm500337r  0.52
2014 Foley MH, Forcier T, McAndrew E, Gonzalez M, Chen H, Juelg B, Walker BD, Irvine DJ. High avidity CD8+ T cells efficiently eliminate motile HIV-infected targets and execute a locally focused program of anti-viral function. Plos One. 9: e87873. PMID 24551068 DOI: 10.1371/journal.pone.0087873  0.52
2014 Liu H, Moynihan KD, Zheng Y, Szeto GL, Li AV, Huang B, Van Egeren DS, Park C, Irvine DJ. Structure-based programming of lymph-node targeting in molecular vaccines. Nature. 507: 519-22. PMID 24531764 DOI: 10.1038/nature12978  0.52
2013 DeMuth PC, Li AV, Abbink P, Liu J, Li H, Stanley KA, Smith KM, Lavine CL, Seaman MS, Kramer JA, Miller AD, Abraham W, Suh H, Elkhader J, Hammond PT, ... ... Irvine DJ, et al. Vaccine delivery with microneedle skin patches in nonhuman primates. Nature Biotechnology. 31: 1082-5. PMID 24316643 DOI: 10.1038/nbt.2759  0.52
2013 Irvine DJ, Swartz MA, Szeto GL. Engineering synthetic vaccines using cues from natural immunity. Nature Materials. 12: 978-90. PMID 24150416 DOI: 10.1038/nmat3775  0.52
2013 Li AV, Moon JJ, Abraham W, Suh H, Elkhader J, Seidman MA, Yen M, Im EJ, Foley MH, Barouch DH, Irvine DJ. Generation of effector memory T cell-based mucosal and systemic immunity with pulmonary nanoparticle vaccination. Science Translational Medicine. 5: 204ra130. PMID 24068737 DOI: 10.1126/scitranslmed.3006516  0.52
2013 Van Lehn RC, Atukorale PU, Carney RP, Yang YS, Stellacci F, Irvine DJ, Alexander-Katz A. Effect of particle diameter and surface composition on the spontaneous fusion of monolayer-protected gold nanoparticles with lipid bilayers. Nano Letters. 13: 4060-7. PMID 23915118 DOI: 10.1021/nl401365n  0.52
2013 Zheng Y, Stephan MT, Gai SA, Abraham W, Shearer A, Irvine DJ. In vivo targeting of adoptively transferred T-cells with antibody- and cytokine-conjugated liposomes Journal of Controlled Release. 172: 426-435. PMID 23770010 DOI: 10.1016/j.jconrel.2013.05.037  0.52
2013 Demuth PC, Garcia-Beltran WF, Ai-Ling ML, Hammond PT, Irvine DJ. Composite dissolving microneedles for coordinated control of antigen and adjuvant delivery kinetics in transcutaneous vaccination. Advanced Functional Materials. 23: 161-172. PMID 23503923 DOI: 10.1002/adfm.201201512  0.52
2013 Ackerman ME, Dugast AS, McAndrew EG, Tsoukas S, Licht AF, Irvine DJ, Alter G. Enhanced phagocytic activity of HIV-specific antibodies correlates with natural production of immunoglobulins with skewed affinity for FcγR2a and FcγR2b. Journal of Virology. 87: 5468-76. PMID 23468489 DOI: 10.1128/JVI.03403-12  0.52
2013 Su X, Yang N, Wittrup KD, Irvine DJ. Synergistic antitumor activity from two-stage delivery of targeted toxins and endosome-disrupting nanoparticles. Biomacromolecules. 14: 1093-102. PMID 23444913 DOI: 10.1021/bm3019906  0.52
2013 Kwong B, Gai SA, Elkhader J, Wittrup KD, Irvine DJ. Localized immunotherapy via liposome-anchored Anti-CD137 + IL-2 prevents lethal toxicity and elicits local and systemic antitumor immunity. Cancer Research. 73: 1547-58. PMID 23436794 DOI: 10.1158/0008-5472.CAN-12-3343  0.52
2013 Wang Y, Irvine DJ. Convolution of chemoattractant secretion rate, source density, and receptor desensitization direct diverse migration patterns in leukocytes Integrative Biology (United Kingdom). 5: 481-494. PMID 23392181 DOI: 10.1039/c3ib20249f  0.52
2013 DeMuth PC, Min Y, Huang B, Kramer JA, Miller AD, Barouch DH, Hammond PT, Irvine DJ. Polymer multilayer tattooing for enhanced DNA vaccination. Nature Materials. 12: 367-76. PMID 23353628 DOI: 10.1038/nmat3550  0.52
2012 DeMuth PC, Moon JJ, Suh H, Hammond PT, Irvine DJ. Releasable layer-by-layer assembly of stabilized lipid nanocapsules on microneedles for enhanced transcutaneous vaccine delivery. Acs Nano. 6: 8041-51. PMID 22920601 DOI: 10.1021/nn302639r  0.52
2012 Moon JJ, Huang B, Irvine DJ. Engineering Nano- and microparticles to tune immunity Advanced Materials. 24: 3724-3746. PMID 22641380 DOI: 10.1002/adma.201200446  0.52
2012 Stephan MT, Stephan SB, Bak P, Chen J, Irvine DJ. Synapse-directed delivery of immunomodulators using T-cell-conjugated nanoparticles Biomaterials. 33: 5776-5787. PMID 22594972 DOI: 10.1016/j.biomaterials.2012.04.029  0.52
2012 Metallo CM, Gameiro PA, Bell EL, Mattaini KR, Yang J, Hiller K, Jewell CM, Johnson ZR, Irvine DJ, Guarente L, Kelleher JK, Vander Heiden MG, Iliopoulos O, Stephanopoulos G. Reductive glutamine metabolism by IDH1 mediates lipogenesis under hypoxia Nature. 481: 380-384. PMID 22101433 DOI: 10.1038/nature10602  0.52
2011 Jewell CM, Jung JM, Atukorale PU, Carney RP, Stellacci F, Irvine DJ. Oligonucleotide delivery by cell-penetrating "striped" nanoparticles. Angewandte Chemie (International Ed. in English). 50: 12312-5. PMID 22028047 DOI: 10.1002/anie.201104514  0.52
2011 Jewell CM, Bustamante Lo?ez SC, Irvine DJ. In situ engineering of the lymph node microenvironment via intranodal injection of adjuvant-releasing polymer particles Proceedings of the National Academy of Sciences of the United States of America. 108: 15745-15750. PMID 21896725 DOI: 10.1073/pnas.1105200108  0.52
2011 Martínez-Martín N, Fernández-Arenas E, Cemerski S, Delgado P, Turner M, Heuser J, Irvine DJ, Huang B, Bustelo XR, Shaw A, Alarcón B. T cell receptor internalization from the immunological synapse is mediated by TC21 and RhoG GTPase-dependent phagocytosis. Immunity. 35: 208-22. PMID 21820331 DOI: 10.1016/j.immuni.2011.06.003  0.52
2011 Yoo JW, Irvine DJ, Discher DE, Mitragotri S. Bio-inspired, bioengineered and biomimetic drug delivery carriers. Nature Reviews. Drug Discovery. 10: 521-35. PMID 21720407 DOI: 10.1038/nrd3499  0.52
2011 Dahirel V, Shekhar K, Pereyra F, Miura T, Artyomov M, Talsania S, Allen TM, Altfeld M, Carrington M, Irvine DJ, Walker BD, Chakraborty AK. Coordinate linkage of HIV evolution reveals regions of immunological vulnerability. Proceedings of the National Academy of Sciences of the United States of America. 108: 11530-5. PMID 21690407 DOI: 10.1073/pnas.1105315108  0.52
2011 Liu H, Kwong B, Irvine DJ. Membrane anchored immunostimulatory oligonucleotides for in vivo cell modification and localized immunotherapy. Angewandte Chemie (International Ed. in English). 50: 7052-5. PMID 21688362 DOI: 10.1002/anie.201101266  0.52
2011 De Temmerman ML, Rejman J, Demeester J, Irvine DJ, Gander B, De Smedt SC. Particulate vaccines: On the quest for optimal delivery and immune response Drug Discovery Today. 16: 569-582. PMID 21570475 DOI: 10.1016/j.drudis.2011.04.006  0.52
2011 Kwong B, Liu H, Irvine DJ. Induction of potent anti-tumor responses while eliminating systemic side effects via liposome-anchored combinatorial immunotherapy. Biomaterials. 32: 5134-47. PMID 21514665 DOI: 10.1016/j.biomaterials.2011.03.067  0.52
2011 Melvin AT, Welf ES, Wang Y, Irvine DJ, Haugh JM. In chemotaxing fibroblasts, both high-fidelity and weakly biased cell movements track the localization of PI3K signaling. Biophysical Journal. 100: 1893-901. PMID 21504725 DOI: 10.1016/j.bpj.2011.02.047  0.52
2011 Irvine DJ. Drug delivery: One nanoparticle, one kill Nature Materials. 10: 342-343. PMID 21499312 DOI: 10.1038/nmat3014  0.52
2011 Wang Y, Irvine DJ. Engineering chemoattractant gradients using chemokine-releasing polysaccharide microspheres Biomaterials. 32: 4903-4913. PMID 21463892 DOI: 10.1016/j.biomaterials.2011.03.027  0.52
2011 Su X, Fricke J, Kavanagh DG, Irvine DJ. In vitro and in vivo mRNA delivery using lipid-enveloped pH-responsive polymer nanoparticles Molecular Pharmaceutics. 8: 774-787. PMID 21417235 DOI: 10.1021/mp100390w  0.52
2011 Palmer MJ, Mahajan VS, Chen J, Irvine DJ, Lauffenburger DA. Signaling thresholds govern heterogeneity in IL-7-receptor-mediated responses of naïve CD8(+) T cells. Immunology and Cell Biology. 89: 581-94. PMID 21339767 DOI: 10.1038/icb.2011.5  0.52
2011 Moon JJ, Suh H, Bershteyn A, Stephan MT, Liu H, Huang B, Sohail M, Luo S, Um SH, Khant H, Goodwin JT, Ramos J, Chiu W, Irvine DJ. Interbilayer-crosslinked multilamellar vesicles as synthetic vaccines for potent humoral and cellular immune responses. Nature Materials. 10: 243-51. PMID 21336265 DOI: 10.1038/nmat2960  0.52
2010 DeMuth PC, Su X, Samuel RE, Hammond PT, Irvine DJ. Nano-layered microneedles for transcutaneous delivery of polymer nanoparticles and plasmid DNA. Advanced Materials (Deerfield Beach, Fla.). 22: 4851-6. PMID 20859938 DOI: 10.1002/adma.201001525  0.52
2010 Stephan MT, Moon JJ, Um SH, Bersthteyn A, Irvine DJ. Therapeutic cell engineering with surface-conjugated synthetic nanoparticles Nature Medicine. 16: 1035-1041. PMID 20711198 DOI: 10.1038/nm.2198  0.52
2010 Swiston AJ, Gilbert JB, Irvine DJ, Cohen RE, Rubner MF. Freely suspended cellular "backpacks" lead to cell aggregate self-assembly. Biomacromolecules. 11: 1826-32. PMID 20527876 DOI: 10.1021/bm100305h  0.52
2010 Phee H, Dzhagalov I, Mollenauer M, Wang Y, Irvine DJ, Robey E, Weiss A. Regulation of thymocyte positive selection and motility by GIT2. Nature Immunology. 11: 503-11. PMID 20431621 DOI: 10.1038/ni.1868  0.52
2009 Su X, Kim BS, Kim SR, Hammond PT, Irvine DJ. Layer-by-layer-assembled multilayer films for transcutaneous drug and vaccine delivery. Acs Nano. 3: 3719-29. PMID 19824655 DOI: 10.1021/nn900928u  0.52
2002 Koo LY, Irvine DJ, Mayes AM, Lauffenburger DA, Griffith LG. Co-regulation of cell adhesion by nanoscale RGD organization and mechanical stimulus. Journal of Cell Science. 115: 1423-33. PMID 11896190  0.52
2002 Irvine DJ, Hue KA, Mayes AM, Griffith LG. Simulations of cell-surface integrin binding to nanoscale-clustered adhesion ligands. Biophysical Journal. 82: 120-32. PMID 11751301 DOI: 10.1016/S0006-3495(02)75379-4  0.52
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