| Year |
Citation |
Score |
| 2019 |
Montgomery D, Anand JP, Griggs N, Fernandez TJ, Hartman JG, Sanchez-Santiago AA, Pogozheva ID, Traynor JR, Mosberg HI. Novel Dimethyltyrosine-Tetrahydroisoquinoline Peptidomimetics with Aromatic Tetrahydroisoquinoline Substitutions Show In Vitro Kappa and Mu Opioid Receptor Agonism. Acs Chemical Neuroscience. PMID 31199621 DOI: 10.1021/Acschemneuro.9B00250 |
0.832 |
|
| 2019 |
Henry S, Fernandez TM, Anand JP, Griggs N, Traynor JR, Mosberg HI. Structural Simplification of a Tetrahydroquinoline Core Peptidomimetic µ-Opioid-Receptor (MOR) Agonist/ δ-Opioid Receptor (DOR) Antagonist Produces Improved Metabolic Stability . Journal of Medicinal Chemistry. PMID 30924650 DOI: 10.1021/Acs.Jmedchem.9B00219 |
0.823 |
|
| 2019 |
Nastase AF, Anand JP, Bender AM, Montgomery D, Griggs N, Fernandez TJ, Jutkiewicz EM, Traynor JR, Mosberg HI. Dual Pharmacophores Explored via Structure-Activity Relationship (SAR) Matrix: Insights into Potent, Bifunctional Opioid Ligand Design. Journal of Medicinal Chemistry. PMID 30916966 DOI: 10.1021/Acs.Jmedchem.9B00378 |
0.821 |
|
| 2018 |
Nastase AF, Griggs NW, Anand JP, Fernandez TJ, Harland AA, Trask TJ, Jutkiewicz EM, Traynor JR, Mosberg HI. Synthesis and pharmacological evaluation of novel C-8 substituted tetrahydroquinolines as balanced-affinity mu/delta opioid ligands for the treatment of pain. Acs Chemical Neuroscience. PMID 29677442 DOI: 10.1021/Acschemneuro.8B00139 |
0.819 |
|
| 2018 |
Anand JP, Kochan KE, Nastase AF, Montgomery D, Griggs NW, Traynor JR, Mosberg HI, Jutkiewicz EM. In Vivo Effects of μ Opioid Receptor Agonist/δ Opioid Receptor Antagonist Peptidomimetics Following Acute and Repeated Administration. British Journal of Pharmacology. PMID 29352503 DOI: 10.1111/Bph.14148 |
0.829 |
|
| 2017 |
Harland AA, Pogozheva ID, Griggs NW, Trask TJ, Traynor JR, Mosberg HI. Placement of hydroxy moiety on pendant of peptidomimetic scaffold modulates mu and kappa opioid receptor efficacy. Acs Chemical Neuroscience. PMID 28796483 DOI: 10.1021/Acschemneuro.7B00284 |
0.83 |
|
| 2016 |
Healy JR, Bezawada P, Griggs NW, Devereaux AL, Matsumoto RR, Traynor JR, Coop A, Cunningham CW. Benzylideneoxymorphone: A new lead for development of bifunctional mu/delta opioid receptor ligands. Bioorganic & Medicinal Chemistry Letters. PMID 28011222 DOI: 10.1016/j.bmcl.2016.11.057 |
0.852 |
|
| 2016 |
Harland AA, Bender AM, Griggs NW, Gao C, Anand JP, Pogozheva ID, Traynor JR, Jutkiewicz EM, Mosberg HI. Effects of N-Substitutions on the Tetrahydroquinoline (THQ) core of Mixed-Efficacy μ-Opioid Receptor (MOR)/ δ-Opioid Receptor (DOR) Ligands. Journal of Medicinal Chemistry. PMID 27148755 DOI: 10.1021/Acs.Jmedchem.6B00308 |
0.831 |
|
| 2015 |
Bender AM, Griggs NW, Gao C, Trask TJ, Traynor JR, Mosberg HI. Rapid Synthesis of Boc-2',6'-dimethyl-l-tyrosine and Derivatives and Incorporation into Opioid Peptidomimetics. Acs Medicinal Chemistry Letters. 6: 1199-203. PMID 26713104 DOI: 10.1021/Acsmedchemlett.5B00344 |
0.788 |
|
| 2015 |
Yao XQ, Malik R, Griggs NW, Skjaerven L, Traynor JR, Sivaramakrishnan S, Grant BJ. Dynamic coupling and allosteric networks in the alpha subunit of heterotrimeric G proteins. The Journal of Biological Chemistry. PMID 26703464 DOI: 10.1016/J.Bpj.2015.11.2306 |
0.461 |
|
| 2015 |
Harland AA, Yeomans L, Griggs NW, Anand JP, Pogozheva ID, Jutkiewicz EM, Traynor JR, Mosberg HI. Further Optimization and Evaluation of Bioavailable, Mixed-Efficacy μ-Opioid Receptor (MOR) Agonists/ δ-Opioid Receptor (DOR) Antagonists: Balancing MOR and DOR Affinities. Journal of Medicinal Chemistry. PMID 26524472 DOI: 10.1021/Acs.Jmedchem.5B01270 |
0.837 |
|
| 2015 |
Bender AM, Griggs NW, Anand JP, Traynor JR, Jutkiewicz EM, Mosberg HI. Asymmetric Synthesis and in Vitro and in Vivo Activity of Tetrahydroquinolines Featuring a Diverse Set of Polar Substitutions at the 6 Position as Mixed-Efficacy μ Opioid Receptor/δ Opioid Receptor Ligands. Acs Chemical Neuroscience. 6: 1428-35. PMID 25938166 DOI: 10.1021/Acschemneuro.5B00100 |
0.828 |
|
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