Geoffrey G. Murphy, Ph.D. - Publications

1) Molecular & Behavioral Neuroscience Institute 2) Molecular and Integrative Physiology University of Michigan Medical School, Ann Arbor, MI, United States 
Ion Channels, Cognition, Aging, Epilepsy

64 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2021 Desai AA, Smith MD, Zhang Y, Makowski EK, Gerson JE, Ionescu E, Starr CG, Zupancic JM, Moore SJ, Sutter AB, Ivanova MI, Murphy GG, Paulson HL, Tessier PM. Rational affinity maturation of anti-amyloid antibodies with high conformational and sequence specificity. The Journal of Biological Chemistry. 100508. PMID 33675750 DOI: 10.1016/j.jbc.2021.100508  0.92
2020 Rodriguez G, Moore SJ, Neff RC, Glass ED, Stevenson TK, Stinnett GS, Seasholtz AF, Murphy GG, Cazares VA. Deficits across multiple behavioral domains align with susceptibility to stress in 129S1/SvImJ mice. Neurobiology of Stress. 13: 100262. PMID 33344715 DOI: 10.1016/j.ynstr.2020.100262  0.92
2020 Ghoweri AO, Ouillette L, Frazier HN, Anderson KL, Lin RL, Gant JC, Parent R, Moore S, Murphy GG, Thibault O. Electrophysiological and Imaging Calcium Biomarkers of Aging in Male and Female 5×FAD Mice. Journal of Alzheimer's Disease : Jad. PMID 33164928 DOI: 10.3233/JAD-200109  0.4
2020 Sharkey LM, Sandoval-Pistorius SS, Moore SJ, Gerson JE, Komlo R, Fischer S, Negron-Rios KY, Crowley EV, Padron F, Patel R, Murphy GG, Paulson HL. Modeling UBQLN2-mediated neurodegenerative disease in mice: Shared and divergent properties of wild type and mutant UBQLN2 in phase separation, subcellular localization, altered proteostasis pathways, and selective cytotoxicity. Neurobiology of Disease. 105016. PMID 32653673 DOI: 10.1016/j.nbd.2020.105016  0.92
2020 Dang LT, Glanowska KM, Iffland Ii PH, Barnes AE, Baybis M, Liu Y, Patino G, Vaid S, Streicher AM, Parker WE, Kim S, Moon UY, Henry FE, Murphy GG, Sutton M, et al. Multimodal Analysis of STRADA Function in Brain Development. Frontiers in Cellular Neuroscience. 14: 122. PMID 32457579 DOI: 10.3389/Fncel.2020.00122  0.96
2020 Moore SJ, Murphy GG. The Role of L-Type Calcium Channels in Neuronal Excitability and Aging. Neurobiology of Learning and Memory. 107230. PMID 32407963 DOI: 10.1016/j.nlm.2020.107230  0.92
2020 Moore SJ, Murphy GG, Cazares VA. Turning strains into strengths for understanding psychiatric disorders. Molecular Psychiatry. PMID 32404949 DOI: 10.1038/S41380-020-0772-Y  0.92
2020 Arias-Hervert ER, Xu N, Njus M, Murphy GG, Hou Y, Williams JA, Lentz SI, Ernst SA, Stuenkel EL. Actions of Rab27B-GTPase on mammalian central excitatory synaptic transmission. Physiological Reports. 8: e14428. PMID 32358861 DOI: 10.14814/Phy2.14428  0.48
2019 Althaus AL, Moore SJ, Zhang H, Du Plummer X, Murphy GG, Parent JM. Altered Synaptic Drive onto Birthdated Dentate Granule Cells in Experimental Temporal Lobe Epilepsy. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. PMID 31270158 DOI: 10.1523/Jneurosci.0654-18.2019  0.96
2019 Cazares VA, Rodriguez G, Parent R, Ouillette L, Glanowska KM, Moore SJ, Murphy GG. Environmental Variables that Ameliorate Extinction Learning Deficits in the 129S1/SvlmJ Mouse Strain. Genes, Brain, and Behavior. e12575. PMID 30973205 DOI: 10.1111/Gbb.12575  0.92
2018 Hu S, Knowlton RC, Watson BO, Glanowska KM, Murphy GG, Parent JM, Wang Y. Somatic Depdc5 deletion recapitulates electroclinical features of human focal cortical dysplasia type IIA. Annals of Neurology. PMID 30080265 DOI: 10.1002/Ana.25272  0.96
2018 Wang Y, Ji T, Nelson AD, Glanowska K, Murphy GG, Jenkins PM, Parent JM. Critical roles of αII spectrin in brain development and epileptic encephalopathy. The Journal of Clinical Investigation. PMID 29337302 DOI: 10.1172/Jci95743  0.96
2018 Zhao XF, Kohen R, Parent R, Duan Y, Fisher GL, Korn MJ, Ji L, Wan G, Jin J, Püschel AW, Dolan DF, Parent JM, Corfas G, Murphy GG, Giger RJ. PlexinA2 Forward Signaling through Rap1 GTPases Regulates Dentate Gyrus Development and Schizophrenia-like Behaviors. Cell Reports. 22: 456-470. PMID 29320740 DOI: 10.1016/J.Celrep.2017.12.044  0.96
2017 Temme SJ, Murphy GG. The L-type voltage-gated calcium channel CaV1.2 mediates fear extinction and modulates synaptic tone in the lateral amygdala. Learning & Memory (Cold Spring Harbor, N.Y.). 24: 580-588. PMID 29038219 DOI: 10.1101/Lm.045773.117  1
2017 Buonarati OR, Henderson PB, Murphy GG, Horne MC, Hell JW. Proteolytic processing of the L-type Ca (2+) channel alpha 11.2 subunit in neurons. F1000research. 6: 1166. PMID 28781760 DOI: 10.12688/F1000RESEARCH.11808.2  0.4
2017 Buonarati OR, Henderson PB, Murphy GG, Horne MC, Hell JW. Proteolytic processing of the L-type Ca2+ channel alpha11.2 subunit in neurons F1000research. 6: 1166. DOI: 10.12688/F1000Research.11808.1  0.4
2016 Temme SJ, Bell RZ, Fisher GL, Murphy GG. Deletion of the Mouse Homolog of CACNA1C Disrupts Discrete Forms of Hippocampal-Dependent Memory and Neurogenesis within the Dentate Gyrus. Eneuro. 3. PMID 27957527 DOI: 10.1523/ENEURO.0118-16.2016  1
2016 Krueger JN, Moore SJ, Parent R, McKinney BC, Lee A, Murphy GG. A novel mouse model of the aged brain: Over-expression of the L-type voltage-gated calcium channel CaV1.3. Behavioural Brain Research. PMID 27368417 DOI: 10.1016/j.bbr.2016.06.054  1
2016 Cheli VT, Santiago González DA, Smith J, Spreuer V, Murphy GG, Paez PM. L-type voltage-operated calcium channels contribute to astrocyte activation In vitro. Glia. PMID 27247164 DOI: 10.1002/glia.23013  1
2016 Patriarchi T, Qian H, Di Biase V, Malik ZA, Chowdhury D, Price JL, Hammes EA, Buonarati OR, Westenbroek RE, Catterall WA, Hofmann F, Xiang YK, Murphy GG, Chen CY, Navedo MF, et al. Phosphorylation of Cav1.2 on S1928 uncouples the L-type Ca2+ channel from the β2 adrenergic receptor. The Embo Journal. PMID 27103070 DOI: 10.15252/Embj.201593409  1
2016 Williams AJ, Yee P, Smith MC, Murphy GG, Umemori H. Deletion of Fibroblast Growth Factor 22 (FGF22) causes a depression-like phenotype in adult mice. Behavioural Brain Research. PMID 27036645 DOI: 10.1016/j.bbr.2016.03.047  1
2016 Singer BH, Newstead MW, Zeng X, Cooke CL, Thompson RC, Singer K, Ghantasala R, Parent JM, Murphy GG, Iwashyna TJ, Standiford TJ. Cecal Ligation and Puncture Results in Long-Term Central Nervous System Myeloid Inflammation. Plos One. 11: e0149136. PMID 26862765 DOI: 10.1371/Journal.Pone.0149136  1
2016 Jones JM, Dionne L, Dell'Orco J, Parent R, Krueger JN, Cheng X, Dib-Hajj SD, Bunton-Stasyshyn RK, Sharkey LM, Dowling JJ, Murphy GG, Shakkottai VG, Shrager P, Meisler MH. Single amino acid deletion in transmembrane segment D4S6 of sodium channel Scn8a (Nav1.6) in a mouse mutant with a chronic movement disorder. Neurobiology of Disease. PMID 26807988 DOI: 10.1016/J.Nbd.2016.01.018  1
2015 Su EJ, Fredriksson L, Kanzawa M, Moore S, Folestad E, Stevenson TK, Nilsson I, Sashindranath M, Schielke GP, Warnock M, Ragsdale M, Mann K, Lawrence AL, Medcalf RL, Eriksson U, ... Murphy GG, et al. Imatinib treatment reduces brain injury in a murine model of traumatic brain injury. Frontiers in Cellular Neuroscience. 9: 385. PMID 26500491 DOI: 10.3389/fncel.2015.00385  1
2015 Berkowitz BA, Murphy GG, Craft CM, Surmeier DJ, Roberts R. Genetic dissection of horizontal cell inhibitory signaling in mice in complete darkness in vivo. Investigative Ophthalmology & Visual Science. 56: 3132-9. PMID 26024096 DOI: 10.1167/Iovs.15-16581  1
2015 Zhong L, Brown J, Kramer A, Kaleka K, Petersen A, Krueger JN, Florence M, Muelbl MJ, Battle M, Murphy GG, Olsen CM, Gerges NZ. Increased prefrontal cortex neurogranin enhances plasticity and extinction learning. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 35: 7503-8. PMID 25972176 DOI: 10.1523/Jneurosci.0274-15.2015  1
2015 Atkin G, Moore S, Lu Y, Nelson RF, Tipper N, Rajpal G, Hunt J, Tennant W, Hell JW, Murphy GG, Paulson H. Loss of F-box only protein 2 (Fbxo2) disrupts levels and localization of select NMDA receptor subunits, and promotes aberrant synaptic connectivity. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 35: 6165-78. PMID 25878288 DOI: 10.1523/Jneurosci.3013-14.2015  1
2015 Althaus AL, Sagher O, Parent JM, Murphy GG. Intrinsic neurophysiological properties of hilar ectopic and normotopic dentate granule cells in human temporal lobe epilepsy and a rat model. Journal of Neurophysiology. 113: 1184-94. PMID 25429123 DOI: 10.1152/jn.00835.2014  1
2015 Wagnon JL, Korn MJ, Parent R, Tarpey TA, Jones JM, Hammer MF, Murphy GG, Parent JM, Meisler MH. Convulsive seizures and SUDEP in a mouse model of SCN8A epileptic encephalopathy. Human Molecular Genetics. 24: 506-15. PMID 25227913 DOI: 10.1093/Hmg/Ddu470  1
2015 Moore SJ, Murphy GG. Age-Related Alterations in Neural Plasticity Handbook of the Biology of Aging: Eighth Edition. 391-405. DOI: 10.1016/B978-0-12-411596-5.00014-9  0.96
2014 Kim E, Wang Y, Kim SJ, Bornhorst M, Jecrois ES, Anthony TE, Wang C, Li YE, Guan JL, Murphy GG, Zhu Y. Transient inhibition of the ERK pathway prevents cerebellar developmental defects and improves long-term motor functions in murine models of neurofibromatosis type 1. Elife. 3. PMID 25535838 DOI: 10.7554/Elife.05151  0.48
2014 Temme SJ, Bell RZ, Pahumi R, Murphy GG. Comparison of inbred mouse substrains reveals segregation of maladaptive fear phenotypes. Frontiers in Behavioral Neuroscience. 8: 282. PMID 25191238 DOI: 10.3389/Fnbeh.2014.00282  1
2014 Murphy GG. The Heat is On: L-type Calcium Channels and Febrile Seizures. Epilepsy Currents / American Epilepsy Society. 14: 93-4. PMID 24872789 DOI: 10.5698/1535-7597-14.2.93  1
2014 Murphy G. Early influences: Seizures during infancy influence behavior in young adult mice Epilepsy Currents. 14: 353-354.  1
2013 Moore SJ, Deshpande K, Stinnett GS, Seasholtz AF, Murphy GG. Conversion of short-term to long-term memory in the novel object recognition paradigm. Neurobiology of Learning and Memory. 105: 174-85. PMID 23835143 DOI: 10.1016/J.Nlm.2013.06.014  1
2013 Parent JM, Murphy GG. Ganglionic eminence graft pre-eminence in epilepsy. Nature Neuroscience. 16: 656-8. PMID 23712064 DOI: 10.1038/nn.3406  1
2013 Fink CG, Murphy GG, Zochowski M, Booth V. A dynamical role for acetylcholine in synaptic renormalization. Plos Computational Biology. 9: e1002939. PMID 23516342 DOI: 10.1371/Journal.Pcbi.1002939  1
2013 Murphy GG. Spatial Learning and Memory-What's TLE Got To Do With It? Epilepsy Currents / American Epilepsy Society. 13: 26-9. PMID 23447735 DOI: 10.5698/1535-7511-13.1.26  1
2011 Rose RA, Sellan M, Simpson JA, Izaddoustdar F, Cifelli C, Panama BK, Davis M, Zhao D, Markhani M, Murphy GG, Striessnig J, Liu PP, Heximer SP, Backx PH. Iron overload decreases CaV1.3-dependent L-type Ca2+ currents leading to bradycardia, altered electrical conduction, and atrial fibrillation. Circulation. Arrhythmia and Electrophysiology. 4: 733-42. PMID 21747058 DOI: 10.1161/Circep.110.960401  1
2011 Moore SJ, Throesch BT, Murphy GG. Of mice and intrinsic excitability: genetic background affects the size of the postburst afterhyperpolarization in CA1 pyramidal neurons. Journal of Neurophysiology. 106: 1570-80. PMID 21697442 DOI: 10.1152/jn.00257.2011  1
2011 Singer BH, Gamelli AE, Fuller CL, Temme SJ, Parent JM, Murphy GG. Compensatory network changes in the dentate gyrus restore long-term potentiation following ablation of neurogenesis in young-adult mice. Proceedings of the National Academy of Sciences of the United States of America. 108: 5437-42. PMID 21402918 DOI: 10.1073/Pnas.1015425108  1
2011 Perkowski JJ, Murphy GG. Deletion of the mouse homolog of KCNAB2, a gene linked to monosomy 1p36, results in associative memory impairments and amygdala hyperexcitability. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 31: 46-54. PMID 21209188 DOI: 10.1523/Jneurosci.2634-10.2011  1
2011 Gamelli AE, McKinney BC, White JA, Murphy GG. Deletion of the L-type calcium channel Ca(V) 1.3 but not Ca(V) 1.2 results in a diminished sAHP in mouse CA1 pyramidal neurons. Hippocampus. 21: 133-41. PMID 20014384 DOI: 10.1002/hipo.20728  1
2010 Huang HS, Kubish GM, Redmond TM, Turner DL, Thompson RC, Murphy GG, Uhler MD. Direct transcriptional induction of Gadd45gamma by Ascl1 during neuronal differentiation. Molecular and Cellular Neurosciences. 44: 282-96. PMID 20382226 DOI: 10.1016/J.Mcn.2010.03.014  1
2009 McKinney BC, Sze W, Lee B, Murphy GG. Impaired long-term potentiation and enhanced neuronal excitability in the amygdala of Ca(V)1.3 knockout mice. Neurobiology of Learning and Memory. 92: 519-28. PMID 19595780 DOI: 10.1016/j.nlm.2009.06.012  1
2008 Cui Y, Costa RM, Murphy GG, Elgersma Y, Zhu Y, Gutmann DH, Parada LF, Mody I, Silva AJ. Neurofibromin regulation of ERK signaling modulates GABA release and learning. Cell. 135: 549-60. PMID 18984165 DOI: 10.1016/J.Cell.2008.09.060  1
2008 Parent JM, Murphy GG. Mechanisms and functional significance of aberrant seizure-induced hippocampal neurogenesis. Epilepsia. 49: 19-25. PMID 18522597 DOI: 10.1111/j.1528-1167.2008.01634.x  1
2008 McKinney BC, Sze W, White JA, Murphy GG. L-type voltage-gated calcium channels in conditioned fear: a genetic and pharmacological analysis. Learning & Memory (Cold Spring Harbor, N.Y.). 15: 326-34. PMID 18441291 DOI: 10.1101/lm.893808  1
2008 McKinney BC, Chow CY, Meisler MH, Murphy GG. Exaggerated emotional behavior in mice heterozygous null for the sodium channel Scn8a (Nav1.6). Genes, Brain, and Behavior. 7: 629-38. PMID 18363861 DOI: 10.1111/j.1601-183X.2008.00399.x  1
2008 White JA, McKinney BC, John MC, Powers PA, Kamp TJ, Murphy GG. Conditional forebrain deletion of the L-type calcium channel Ca V 1.2 disrupts remote spatial memories in mice. Learning & Memory (Cold Spring Harbor, N.Y.). 15: 1-5. PMID 18174367 DOI: 10.1101/Lm.773208  1
2008 McKinney BC, Schneider JS, Schafer GL, Lowing JL, Mohan S, Zhao MX, Heng MY, Albin RL, Seasholtz AF, Akil H, Murphy GG. Decreased locomotor activity in mice expressing tTA under control of the CaMKII alpha promoter. Genes, Brain, and Behavior. 7: 203-13. PMID 17640289 DOI: 10.1111/J.1601-183X.2007.00339.X  1
2006 Murphy GG, Shah V, Hell JW, Silva AJ. Investigation of age-related cognitive decline using mice as a model system: neurophysiological correlates. The American Journal of Geriatric Psychiatry : Official Journal of the American Association For Geriatric Psychiatry. 14: 1012-21. PMID 17138808 DOI: 10.1097/01.JGP.0000209404.54310.b3  1
2006 Murphy GG, Rahnama NP, Silva AJ. Investigation of age-related cognitive decline using mice as a model system: behavioral correlates. The American Journal of Geriatric Psychiatry : Official Journal of the American Association For Geriatric Psychiatry. 14: 1004-11. PMID 17138807 DOI: 10.1097/01.JGP.0000209405.27548.7b  1
2006 McKinney BC, Murphy GG. The L-Type voltage-gated calcium channel Cav1.3 mediates consolidation, but not extinction, of contextually conditioned fear in mice. Learning & Memory (Cold Spring Harbor, N.Y.). 13: 584-9. PMID 17015855 DOI: 10.1101/lm.279006  1
2006 Uchida S, Sakai S, Furuichi T, Hosoda H, Toyota K, Ishii T, Kitamoto A, Sekine M, Koike K, Masushige S, Murphy G, Silva AJ, Kida S. Tight regulation of transgene expression by tetracycline-dependent activator and repressor in brain. Genes, Brain, and Behavior. 5: 96-106. PMID 16436193 DOI: 10.1111/J.1601-183X.2005.00139.X  1
2005 Kushner SA, Elgersma Y, Murphy GG, Jaarsma D, van Woerden GM, Hojjati MR, Cui Y, LeBoutillier JC, Marrone DF, Choi ES, De Zeeuw CI, Petit TL, Pozzo-Miller L, Silva AJ. Modulation of presynaptic plasticity and learning by the H-ras/extracellular signal-regulated kinase/synapsin I signaling pathway. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 25: 9721-34. PMID 16237176 DOI: 10.1523/Jneurosci.2836-05.2005  1
2004 Murphy GG, Fedorov NB, Giese KP, Ohno M, Friedman E, Chen R, Silva AJ. Increased neuronal excitability, synaptic plasticity, and learning in aged Kvbeta1.1 knockout mice. Current Biology : Cb. 14: 1907-15. PMID 15530391 DOI: 10.1016/j.cub.2004.10.021  1
2003 Anagnostaras SG, Murphy GG, Hamilton SE, Mitchell SL, Rahnama NP, Nathanson NM, Silva AJ. Selective cognitive dysfunction in acetylcholine M1 muscarinic receptor mutant mice. Nature Neuroscience. 6: 51-8. PMID 12483218 DOI: 10.1038/nn992  1
2002 Costa RM, Federov NB, Kogan JH, Murphy GG, Stern J, Ohno M, Kucherlapati R, Jacks T, Silva AJ. Mechanism for the learning deficits in a mouse model of neurofibromatosis type 1. Nature. 415: 526-30. PMID 11793011 DOI: 10.1038/Nature711  1
2001 Hamilton SE, Hardouin SN, Anagnostaras SG, Murphy GG, Richmond KN, Silva AJ, Feigl EO, Nathanson NM. Alteration of cardiovascular and neuronal function in M1 knockout mice. Life Sciences. 68: 2489-93. PMID 11392617 DOI: 10.1016/S0024-3205(01)01043-8  1
1999 Silva AJ, Murphy GG. cAMP and memory: a seminal lesson from Drosophila and Aplysia. Brain Research Bulletin. 50: 441-2. PMID 10643474 DOI: 10.1016/S0361-9230(99)00124-0  1
1999 Murphy GG, Glanzman DL. Cellular analog of differential classical conditioning in Aplysia: disruption by the NMDA receptor antagonist DL-2-amino-5-phosphonovalerate. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 19: 10595-602. PMID 10575055 DOI: 10.1523/Jneurosci.19-23-10595.1999  1
1997 Murphy GG, Glanzman DL. Mediation of classical conditioning in Aplysia californica by long-term potentiation of sensorimotor synapses. Science (New York, N.Y.). 278: 467-71. PMID 9334306 DOI: 10.1126/science.278.5337.467  1
1996 Murphy GG, Glanzman DL. Enhancement of sensorimotor connections by conditioning-related stimulation in Aplysia depends upon postsynaptic Ca2+. Proceedings of the National Academy of Sciences of the United States of America. 93: 9931-6. PMID 8790434 DOI: 10.1073/Pnas.93.18.9931  1
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