| Year |
Citation |
Score |
| 2023 |
Vaughan RM, Dickson BM, Martin KR, MacKeigan JP. Molecular dynamics simulations provide insights into ULK-101 potency and selectivity toward autophagic kinases ULK1/2. Biorxiv : the Preprint Server For Biology. PMID 38077086 DOI: 10.1101/2023.12.01.569261 |
0.643 |
|
| 2023 |
Martin KR, Celano SL, Sheldon RD, Jones RG, MacKeigan JP. Quantitative Analysis of Autophagy in Single Cells: Differential Response to Amino Acid and Glucose Starvation. Biorxiv : the Preprint Server For Biology. PMID 38077042 DOI: 10.1101/2023.12.01.569679 |
0.627 |
|
| 2023 |
Chacon-Barahona JA, MacKeigan JP, Lanning NJ. Unique Metabolic Contexts Sensitize Cancer Cells and Discriminate between Glycolytic Tumor Types. Cancers. 15. PMID 36831501 DOI: 10.3390/cancers15041158 |
0.66 |
|
| 2023 |
Giannikou K, Martin KR, Abdel-Azim AG, Pamir KJ, Hougard TR, Bagwe S, Tang Y, MacKeigan JP, Kwiatkowski DJ, Henske EP, Lam HC. Spectrum of germline and somatic mitochondrial DNA variants in Tuberous Sclerosis Complex. Frontiers in Genetics. 13: 917993. PMID 36793390 DOI: 10.3389/fgene.2022.917993 |
0.62 |
|
| 2022 |
Vaughan RM, Kordich JJ, Chan CY, Sasi NK, Celano SL, Sisson KA, Van Baren M, Kortus MG, Aguiar DJ, Martin KR, MacKeigan JP. Chemical Biology Screening Identifies a Vulnerability to Checkpoint Kinase Inhibitors in TSC2-Deficient Renal Angiomyolipomas. Frontiers in Oncology. 12: 852859. PMID 35359406 DOI: 10.3389/fonc.2022.852859 |
0.67 |
|
| 2021 |
Klionsky DJ, Abdel-Aziz AK, Abdelfatah S, Abdellatif M, Abdoli A, Abel S, Abeliovich H, Abildgaard MH, Abudu YP, Acevedo-Arozena A, Adamopoulos IE, Adeli K, Adolph TE, Adornetto A, Aflaki E, ... ... MacKeigan JP, et al. Guidelines for the use and interpretation of assays for monitoring autophagy (4th edition). Autophagy. 1-382. PMID 33634751 DOI: 10.1080/15548627.2020.1797280 |
0.712 |
|
| 2019 |
Celano SL, Yco LP, Kortus MG, Solitro AR, Gunaydin H, Scott M, Spooner E, O'Hagan RC, Fuller P, Martin KR, Shumway SD, MacKeigan JP. Identification of Kinases Responsible for p53-Dependent Autophagy. Iscience. 15: 109-118. PMID 31048145 DOI: 10.1016/J.Isci.2019.04.023 |
0.717 |
|
| 2019 |
Guillaume JD, Celano SL, Martin KR, MacKeigan JP. Determining the Impact of Metabolic Nutrients on Autophagy. Methods in Molecular Biology (Clifton, N.J.). 1862: 151-162. PMID 30315466 DOI: 10.1007/978-1-4939-8769-6_11 |
0.713 |
|
| 2018 |
Martin KR, Celano SL, Solitro AR, Gunaydin H, Scott M, O'Hagan RC, Shumway SD, Fuller P, MacKeigan JP. A Potent and Selective ULK1 Inhibitor Suppresses Autophagy and Sensitizes Cancer Cells to Nutrient Stress. Iscience. 8: 74-84. PMID 30292171 DOI: 10.1016/J.Isci.2018.09.012 |
0.723 |
|
| 2018 |
Sasi NK, Coquel F, Lin YL, MacKeigan JP, Pasero P, Weinreich M. DDK Has a Primary Role in Processing Stalled Replication Forks to Initiate Downstream Checkpoint Signaling. Neoplasia (New York, N.Y.). 20: 985-995. PMID 30157471 DOI: 10.1016/J.Neo.2018.08.001 |
0.668 |
|
| 2018 |
Lanning NJ, VanOpstall C, Goodall ML, MacKeigan JP, Looyenga BD. LRRK2 Deficiency Impairs trans-Golgi to Lysosome Trafficking and Endocytic Cargo Degradation in Human Renal Proximal Tubule Epithelial Cells. American Journal of Physiology. Renal Physiology. PMID 30089035 DOI: 10.1152/Ajprenal.00009.2018 |
0.674 |
|
| 2018 |
Burgenske DM, Monsma DJ, MacKeigan JP. Patient-Derived Xenograft Models of Colorectal Cancer: Procedures for Engraftment and Propagation. Methods in Molecular Biology (Clifton, N.J.). 1765: 307-314. PMID 29589317 DOI: 10.1007/978-1-4939-7765-9_20 |
0.644 |
|
| 2017 |
Dunn EM, Billquist EJ, VanderStoep AL, Bax PG, Westrate LM, McLellan LK, Peterson SC, MacKeigan JP, Putzke AP. Dual Roles of Fer Kinase Are Required for Proper Hematopoiesis and Vascular Endothelium Organization during Zebrafish Development. Biology. 6. PMID 29168762 DOI: 10.3390/Biology6040040 |
0.7 |
|
| 2017 |
Merrill NM, Schipper JL, Karnes JB, Kauffman AL, Martin KR, MacKeigan JP. PI3K-C2α knockdown decreases autophagy and maturation of endocytic vesicles. Plos One. 12: e0184909. PMID 28910396 DOI: 10.1371/Journal.Pone.0184909 |
0.707 |
|
| 2017 |
Lanning NJ, Castle JP, Singh SJ, Leon AN, Tovar EA, Sanghera A, MacKeigan JP, Filipp FV, Graveel CR. Metabolic profiling of triple-negative breast cancer cells reveals metabolic vulnerabilities. Cancer & Metabolism. 5: 6. PMID 28852500 DOI: 10.1186/S40170-017-0168-X |
0.676 |
|
| 2017 |
Martin KR, Zhou W, Bowman MJ, Shih J, Au KS, Dittenhafer-Reed KE, Sisson KA, Koeman J, Weisenberger DJ, Cottingham SL, DeRoos ST, Devinsky O, Winn ME, Cherniack AD, Shen H, ... ... MacKeigan JP, et al. The genomic landscape of tuberous sclerosis complex. Nature Communications. 8: 15816. PMID 28643795 DOI: 10.1038/Ncomms15816 |
0.641 |
|
| 2017 |
Sasi NK, Bhutkar A, Lanning NJ, MacKeigan JP, Weinreich M. DDK Promotes Tumor Chemoresistance and Survival via Multiple Pathways. Neoplasia (New York, N.Y.). 19: 439-450. PMID 28448802 DOI: 10.1016/J.Neo.2017.03.001 |
0.721 |
|
| 2016 |
Klionsky DJ, Abdelmohsen K, Abe A, Abedin MJ, Abeliovich H, Acevedo Arozena A, Adachi H, Adams CM, Adams PD, Adeli K, Adhihetty PJ, Adler SG, Agam G, Agarwal R, Aghi MK, ... ... MacKeigan JP, et al. Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition). Autophagy. 12: 1-222. PMID 26799652 DOI: 10.1080/15548627.2015.1100356 |
0.762 |
|
| 2016 |
Solitro AR, MacKeigan JP. Leaving the lysosome behind: novel developments in autophagy inhibition. Future Medicinal Chemistry. 8: 73-86. PMID 26689099 DOI: 10.4155/Fmc.15.166 |
0.696 |
|
| 2015 |
Lane BR, Bissonnette J, Waldherr T, Ritz-Holland D, Chesla D, Cottingham SL, Alberta S, Liu C, Thompson AB, Graveel C, MacKeigan JP, Noyes SL, Smith J, Lakhani N, Steensma MR, et al. Development of a Center for Personalized Cancer Care at a Regional Cancer Center: Feasibility Trial of an Institutional Tumor Sequencing Advisory Board. The Journal of Molecular Diagnostics : Jmd. PMID 26331835 DOI: 10.1016/J.Jmoldx.2015.07.003 |
0.642 |
|
| 2015 |
MacKeigan JP, Krueger DA. Differentiating the mTOR inhibitors everolimus and sirolimus in the treatment of tuberous sclerosis complex. Neuro-Oncology. 17: 1550-9. PMID 26289591 DOI: 10.1093/Neuonc/Nov152 |
0.706 |
|
| 2015 |
Monsma DJ, Cherba DM, Eugster EE, Dylewski DL, Davidson PT, Peterson CA, Borgman AS, Winn ME, Dykema KJ, Webb CP, MacKeigan JP, Duesbery NS, Nickoloff BJ, Monks NR. Melanoma patient derived xenografts acquire distinct Vemurafenib resistance mechanisms. American Journal of Cancer Research. 5: 1507-18. PMID 26101714 |
0.623 |
|
| 2015 |
Wang T, Goodall ML, Gonzales P, Sepulveda M, Martin KR, Gately S, MacKeigan JP. Synthesis of improved lysomotropic autophagy inhibitors. Journal of Medicinal Chemistry. 58: 3025-35. PMID 25793774 DOI: 10.1021/Jm501586M |
0.706 |
|
| 2015 |
Szyma?ska P, Martin KR, MacKeigan JP, Hlavacek WS, Lipniacki T. Computational analysis of an autophagy/translation switch based on mutual inhibition of MTORC1 and ULK1. Plos One. 10: e0116550. PMID 25761126 DOI: 10.1371/Journal.Pone.0116550 |
0.702 |
|
| 2015 |
Burgenske D, Monsma D, Dylewski D, Scott S, Sayfie A, Kim D, Luchtefeld M, Martin K, Stephenson P, Hostetter G, Dujovny N, MacKeigan J. Abstract B50: Targeting KRASG12D colorectal cancer with combined inhibition of PI3K/mTOR and MAPK signaling Molecular Cancer Therapeutics. 14. DOI: 10.1158/1538-8514.Pi3K14-B50 |
0.422 |
|
| 2015 |
Solitro AR, MacKeigan JP. Abstract B08: Kicking the addictions: Therapeutic strategies for NSCLC Molecular Cancer Therapeutics. 14. DOI: 10.1158/1538-8514.Pi3K14-B08 |
0.4 |
|
| 2014 |
Burgenske DM, Monsma DJ, Dylewski D, Scott SB, Sayfie AD, Kim DG, Luchtefeld M, Martin KR, Stephenson P, Hostetter G, Dujovny N, MacKeigan JP. Establishment of genetically diverse patient-derived xenografts of colorectal cancer. American Journal of Cancer Research. 4: 824-37. PMID 25520871 |
0.653 |
|
| 2014 |
Goodall ML, Wang T, Martin KR, Kortus MG, Kauffman AL, Trent JM, Gately S, MacKeigan JP. Development of potent autophagy inhibitors that sensitize oncogenic BRAF V600E mutant melanoma tumor cells to vemurafenib. Autophagy. 10: 1120-36. PMID 24879157 DOI: 10.4161/Auto.28594 |
0.715 |
|
| 2014 |
Lanning NJ, Looyenga BD, Kauffman AL, Niemi NM, Sudderth J, DeBerardinis RJ, MacKeigan JP. A mitochondrial RNAi screen defines cellular bioenergetic determinants and identifies an adenylate kinase as a key regulator of ATP levels. Cell Reports. 7: 907-17. PMID 24767988 DOI: 10.1016/J.Celrep.2014.03.065 |
0.685 |
|
| 2014 |
Westrate LM, Drocco JA, Martin KR, Hlavacek WS, MacKeigan JP. Mitochondrial morphological features are associated with fission and fusion events. Plos One. 9: e95265. PMID 24733410 DOI: 10.1371/Journal.Pone.0095265 |
0.627 |
|
| 2014 |
Niemi NM, Sacoman JL, Westrate LM, Gaither LA, Lanning NJ, Martin KR, MacKeigan JP. The pseudophosphatase MK-STYX physically and genetically interacts with the mitochondrial phosphatase PTPMT1. Plos One. 9: e93896. PMID 24709986 DOI: 10.1371/Journal.Pone.0093896 |
0.709 |
|
| 2014 |
Westrate LM, Sayfie AD, Burgenske DM, MacKeigan JP. Persistent mitochondrial hyperfusion promotes G2/M accumulation and caspase-dependent cell death. Plos One. 9: e91911. PMID 24632851 DOI: 10.1371/Journal.Pone.0091911 |
0.686 |
|
| 2014 |
Martin KR, Narang P, Medina-Franco JL, Meurice N, MacKeigan JP. Integrating virtual and biochemical screening for protein tyrosine phosphatase inhibitor discovery. Methods (San Diego, Calif.). 65: 219-28. PMID 23969317 DOI: 10.1016/J.Ymeth.2013.08.013 |
0.681 |
|
| 2014 |
Looyenga BD, Resau J, MacKeigan JP. Correction: Cytokine Receptor-Like Factor 1 (CRLF1) Protects against 6-Hydroxydopamine Toxicity Independent of the gp130/JAK Signaling Pathway Plos One. 9. DOI: 10.1371/Annotation/7A99F22F-8273-43C0-B78F-8675Ee409Bf6 |
0.636 |
|
| 2013 |
Gombash SE, Manfredsson FP, Kemp CJ, Kuhn NC, Fleming SM, Egan AE, Grant LM, Ciucci MR, MacKeigan JP, Sortwell CE. Morphological and behavioral impact of AAV2/5-mediated overexpression of human wildtype alpha-synuclein in the rat nigrostriatal system. Plos One. 8: e81426. PMID 24312298 DOI: 10.1371/Journal.Pone.0081426 |
0.608 |
|
| 2013 |
Looyenga BD, Resau J, MacKeigan JP. Cytokine receptor-like factor 1 (CRLF1) protects against 6-hydroxydopamine toxicity independent of the gp130/JAK signaling pathway. Plos One. 8: e66548. PMID 23818941 DOI: 10.1371/Journal.Pone.0066548 |
0.665 |
|
| 2013 |
Niemi NM, Lanning NJ, Westrate LM, MacKeigan JP. Downregulation of the mitochondrial phosphatase PTPMT1 is sufficient to promote cancer cell death. Plos One. 8: e53803. PMID 23326511 DOI: 10.1371/Journal.Pone.0053803 |
0.7 |
|
| 2013 |
Martin KR, Barua D, Kauffman AL, Westrate LM, Posner RG, Hlavacek WS, Mackeigan JP. Computational model for autophagic vesicle dynamics in single cells. Autophagy. 9: 74-92. PMID 23196898 DOI: 10.4161/Auto.22532 |
0.668 |
|
| 2013 |
Niemi NM, MacKeigan JP. Mitochondrial phosphorylation in apoptosis: flipping the death switch. Antioxidants & Redox Signaling. 19: 572-82. PMID 23088365 DOI: 10.1089/Ars.2012.4982 |
0.662 |
|
| 2012 |
Martin KR, Narang P, Xu Y, Kauffman AL, Petit J, Xu HE, Meurice N, MacKeigan JP. Identification of small molecule inhibitors of PTPσ through an integrative virtual and biochemical approach. Plos One. 7: e50217. PMID 23185579 DOI: 10.1371/Journal.Pone.0050217 |
0.682 |
|
| 2012 |
Klionsky DJ, Abdalla FC, Abeliovich H, Abraham RT, Acevedo-Arozena A, Adeli K, Agholme L, Agnello M, Agostinis P, Aguirre-Ghiso JA, Ahn HJ, Ait-Mohamed O, Ait-Si-Ali S, Akematsu T, Akira S, ... ... MacKeigan JP, et al. Guidelines for the use and interpretation of assays for monitoring autophagy. Autophagy. 8: 445-544. PMID 22966490 DOI: 10.4161/Auto.19496 |
0.659 |
|
| 2012 |
Looyenga BD, Mackeigan JP. Characterization of differential protein tethering at the plasma membrane in response to epidermal growth factor signaling. Journal of Proteome Research. 11: 3101-11. PMID 22559174 DOI: 10.1021/Pr201077D |
0.651 |
|
| 2012 |
Looyenga BD, Hutchings D, Cherni I, Kingsley C, Weiss GJ, Mackeigan JP. STAT3 is activated by JAK2 independent of key oncogenic driver mutations in non-small cell lung carcinoma. Plos One. 7: e30820. PMID 22319590 DOI: 10.1371/Journal.Pone.0030820 |
0.698 |
|
| 2012 |
Stark MS, Woods SL, Gartside MG, Bonazzi VF, Dutton-Regester K, Aoude LG, Chow D, Sereduk C, Niemi NM, Tang N, Ellis JJ, Reid J, Zismann V, Tyagi S, Muzny D, ... ... MacKeigan JP, et al. Frequent somatic mutations in MAP3K5 and MAP3K9 in metastatic melanoma identified by exome sequencing. Nature Genetics. 44: 165-9. PMID 22197930 DOI: 10.1038/Ng.1041 |
0.7 |
|
| 2011 |
Fogg VC, Lanning NJ, Mackeigan JP. Mitochondria in cancer: at the crossroads of life and death. Chinese Journal of Cancer. 30: 526-39. PMID 21801601 DOI: 10.5732/Cjc.011.10018 |
0.689 |
|
| 2011 |
He Y, Xu Y, Zhang C, Gao X, Dykema KJ, Martin KR, Ke J, Hudson EA, Khoo SK, Resau JH, Alberts AS, MacKeigan JP, Furge KA, Xu HE. Identification of a lysosomal pathway that modulates glucocorticoid signaling and the inflammatory response. Science Signaling. 4: ra44. PMID 21730326 DOI: 10.1126/Scisignal.2001450 |
0.667 |
|
| 2011 |
Ding Y, Huang D, Zhang Z, Smith J, Petillo D, Looyenga BD, Feenstra K, Mackeigan JP, Furge KA, Teh BT. Combined gene expression profiling and RNAi screening in clear cell renal cell carcinoma identify PLK1 and other therapeutic kinase targets. Cancer Research. 71: 5225-34. PMID 21642374 DOI: 10.1158/0008-5472.Can-11-0076 |
0.727 |
|
| 2011 |
Looyenga BD, Cherni I, Mackeigan JP, Weiss GJ. Tailoring tyrosine kinase inhibitors to fit the lung cancer genome. Translational Oncology. 4: 59-70. PMID 21461169 DOI: 10.1593/Tlo.10241 |
0.702 |
|
| 2011 |
Martin KR, Xu Y, Looyenga BD, Davis RJ, Wu CL, Tremblay ML, Xu HE, MacKeigan JP. Identification of PTPsigma as an autophagic phosphatase. Journal of Cell Science. 124: 812-9. PMID 21303930 DOI: 10.1242/Jcs.080341 |
0.707 |
|
| 2011 |
Niemi NM, Lanning NJ, Klomp JA, Tait SW, Xu Y, Dykema KJ, Murphy LO, Gaither LA, Xu HE, Furge KA, Green DR, MacKeigan JP. MK-STYX, a catalytically inactive phosphatase regulating mitochondrially dependent apoptosis. Molecular and Cellular Biology. 31: 1357-68. PMID 21262771 DOI: 10.1128/Mcb.00788-10 |
0.713 |
|
| 2011 |
Looyenga BD, Furge KA, Dykema KJ, Koeman J, Swiatek PJ, Giordano TJ, West AB, Resau JH, Teh BT, MacKeigan JP. Chromosomal amplification of leucine-rich repeat kinase-2 (LRRK2) is required for oncogenic MET signaling in papillary renal and thyroid carcinomas. Proceedings of the National Academy of Sciences of the United States of America. 108: 1439-44. PMID 21220347 DOI: 10.1073/Pnas.1012500108 |
0.721 |
|
| 2011 |
Brooks BR, Yin H, Chow D, Sereduk C, Koeman J, Qian C, MacKeigan JP, Jung S, Kim S, Xu M, Weeraratna A, Brown KM, Trent J. Abstract 4984: Association ofPTENandp16mutational status withMITFexpression may provide a novel context for a phenotype switch in melanoma Cancer Research. 71: 4984-4984. DOI: 10.1158/1538-7445.Am2011-4984 |
0.382 |
|
| 2011 |
Looyenga BD, Furge KA, Dykema KJ, Koeman J, Swiatek PJ, Giordano TJ, West AB, Resau JH, Teh BT, MacKeigan JP. Abstract 4036: Chromosomal amplification of LRRK2 is required for oncogenic MET signaling in papillary renal and thyroid carcinomas Cancer Research. 71: 4036-4036. DOI: 10.1158/1538-7445.Am2011-4036 |
0.463 |
|
| 2011 |
Martin KR, Xu Y, Looyenga BD, Davis RJ, Wu C, Tremblay ML, Xu HE, Mackeigan JP. Abstract 3836: Identification of PTPsigma as an autophagic phosphatase Cancer Research. 71: 3836-3836. DOI: 10.1158/1538-7445.Am2011-3836 |
0.431 |
|
| 2010 |
Klomp JA, Petillo D, Niemi NM, Dykema KJ, Chen J, Yang XJ, Sääf A, Zickert P, Aly M, Bergerheim U, Nordenskjöld M, Gad S, Giraud S, Denoux Y, Yonneau L, ... ... MacKeigan JP, et al. Birt-Hogg-Dubé renal tumors are genetically distinct from other renal neoplasias and are associated with up-regulation of mitochondrial gene expression. Bmc Medical Genomics. 3: 59. PMID 21162720 DOI: 10.1186/1755-8794-3-59 |
0.635 |
|
| 2010 |
Düvel K, Yecies JL, Menon S, Raman P, Lipovsky AI, Souza AL, Triantafellow E, Ma Q, Gorski R, Cleaver S, Vander Heiden MG, MacKeigan JP, Finan PM, Clish CB, Murphy LO, et al. Activation of a metabolic gene regulatory network downstream of mTOR complex 1. Molecular Cell. 39: 171-83. PMID 20670887 DOI: 10.1016/J.Molcel.2010.06.022 |
0.694 |
|
| 2010 |
Furge KA, MacKeigan JP, Teh BT. Kinase targets in renal-cell carcinomas: reassessing the old and discovering the new. The Lancet. Oncology. 11: 571-8. PMID 20381423 DOI: 10.1016/S1470-2045(09)70380-8 |
0.69 |
|
| 2010 |
Zhou XE, Suino-Powell KM, Li J, He Y, Mackeigan JP, Melcher K, Yong EL, Xu HE. Identification of SRC3/AIB1 as a preferred coactivator for hormone-activated androgen receptor. The Journal of Biological Chemistry. 285: 9161-71. PMID 20086010 DOI: 10.1074/Jbc.M109.085779 |
0.64 |
|
| 2009 |
Nicklin P, Bergman P, Zhang B, Triantafellow E, Wang H, Nyfeler B, Yang H, Hild M, Kung C, Wilson C, Myer VE, MacKeigan JP, Porter JA, Wang YK, Cantley LC, et al. Bidirectional transport of amino acids regulates mTOR and autophagy. Cell. 136: 521-34. PMID 19203585 DOI: 10.1016/J.Cell.2008.11.044 |
0.669 |
|
| 2008 |
Duesbery NS, MacKeigan JP. Origins of cancer. Oncogene. 27: S2. PMID 19956176 DOI: 10.1038/Onc.2009.347 |
0.626 |
|
| 2008 |
Elis W, Triantafellow E, Wolters NM, Sian KR, Caponigro G, Borawski J, Gaither LA, Murphy LO, Finan PM, Mackeigan JP. Down-regulation of class II phosphoinositide 3-kinase alpha expression below a critical threshold induces apoptotic cell death. Molecular Cancer Research : McR. 6: 614-23. PMID 18403640 DOI: 10.1158/1541-7786.Mcr-07-0262 |
0.72 |
|
| 2008 |
Wolters NM, MacKeigan JP. From sequence to function: using RNAi to elucidate mechanisms of human disease. Cell Death and Differentiation. 15: 809-19. PMID 18202701 DOI: 10.1038/Sj.Cdd.4402311 |
0.658 |
|
| 2005 |
Dimitri CA, Dowdle W, MacKeigan JP, Blenis J, Murphy LO. Spatially separate docking sites on ERK2 regulate distinct signaling events in vivo. Current Biology : Cb. 15: 1319-24. PMID 16051177 DOI: 10.1016/J.Cub.2005.06.037 |
0.743 |
|
| 2005 |
Mackeigan JP, Murphy LO, Dimitri CA, Blenis J. Graded mitogen-activated protein kinase activity precedes switch-like c-Fos induction in mammalian cells. Molecular and Cellular Biology. 25: 4676-82. PMID 15899869 DOI: 10.1128/Mcb.25.11.4676-4682.2005 |
0.753 |
|
| 2005 |
MacKeigan JP, Murphy LO, Blenis J. Sensitized RNAi screen of human kinases and phosphatases identifies new regulators of apoptosis and chemoresistance. Nature Cell Biology. 7: 591-600. PMID 15864305 DOI: 10.1038/Ncb1258 |
0.782 |
|
| 2005 |
Ballif BA, Roux PP, Gerber SA, MacKeigan JP, Blenis J, Gygi SP. Quantitative phosphorylation profiling of the ERK/p90 ribosomal S6 kinase-signaling cassette and its targets, the tuberous sclerosis tumor suppressors. Proceedings of the National Academy of Sciences of the United States of America. 102: 667-72. PMID 15647351 DOI: 10.1073/Pnas.0409143102 |
0.788 |
|
| 2004 |
Murphy LO, MacKeigan JP, Blenis J. A network of immediate early gene products propagates subtle differences in mitogen-activated protein kinase signal amplitude and duration. Molecular and Cellular Biology. 24: 144-53. PMID 14673150 DOI: 10.1128/Mcb.24.1.144-153.2004 |
0.754 |
|
| 2003 |
MacKeigan JP, Clements CM, Lich JD, Pope RM, Hod Y, Ting JP. Proteomic profiling drug-induced apoptosis in non-small cell lung carcinoma: identification of RS/DJ-1 and RhoGDIalpha. Cancer Research. 63: 6928-34. PMID 14583493 |
0.815 |
|
| 2003 |
Taxman DJ, MacKeigan JP, Clements C, Bergstralh DT, Ting JP. Transcriptional profiling of targets for combination therapy of lung carcinoma with paclitaxel and mitogen-activated protein/extracellular signal-regulated kinase kinase inhibitor. Cancer Research. 63: 5095-104. PMID 12941840 |
0.804 |
|
| 2002 |
MacKeigan JP, Taxman DJ, Hunter D, Earp HS, Graves LM, Ting JP. Inactivation of the antiapoptotic phosphatidylinositol 3-kinase-Akt pathway by the combined treatment of taxol and mitogen-activated protein kinase kinase inhibition. Clinical Cancer Research : An Official Journal of the American Association For Cancer Research. 8: 2091-9. PMID 12114408 |
0.761 |
|
| 2000 |
MacKeigan JP, Collins TS, Ting JP. MEK inhibition enhances paclitaxel-induced tumor apoptosis. The Journal of Biological Chemistry. 275: 38953-6. PMID 11038347 DOI: 10.1074/Jbc.C000684200 |
0.745 |
|
| 1998 |
Niven R, Pearlman R, Wedeking T, Mackeigan J, Noker P, Simpson-Herren L, Smith JG. Biodistribution of radiolabeled lipid-DNA complexes and DNA in mice. Journal of Pharmaceutical Sciences. 87: 1292-9. PMID 9811479 DOI: 10.1021/js980087a |
0.568 |
|
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