Wei Yang, PhD - Publications

Zhejiang University, Faculty of Medicine 
NMDAR, TRMP2 channel.

44 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2024 Ma C, Luo Y, Zhang C, Cheng C, Hua N, Liu X, Wu J, Qin L, Yu P, Luo J, Yang F, Jiang LH, Zhang G, Yang W. Evolutionary trajectory of TRPM2 channel activation by adenosine diphosphate ribose and calcium. Science Bulletin. PMID 38734586 DOI: 10.1016/j.scib.2024.04.052  0.531
2023 Ye P, Fang Q, Hu X, Zou W, Huang M, Ke M, Li Y, Liu M, Cai X, Zhang C, Hua N, Al-Sheikh U, Liu X, Yu P, Jiang P, ... ... Yang W, et al. TRPM2 as a conserved gatekeeper determines the vulnerability of DA neurons by mediating ROS sensing and calcium dyshomeostasis. Progress in Neurobiology. 102530. PMID 37739206 DOI: 10.1016/j.pneurobio.2023.102530  0.498
2021 Yu X, Xie Y, Zhang X, Ma C, Liu L, Zhen W, Xu L, Zhang J, Liang Y, Zhao L, Gao X, Yu P, Luo J, Jiang LH, Nie Y, ... ... Yang W, et al. Structural and functional basis of the selectivity filter as a gate in human TRPM2 channel. Cell Reports. 37: 110025. PMID 34788616 DOI: 10.1016/j.celrep.2021.110025  0.529
2021 Shi X, Zhang Q, Li J, Liu X, Zhang Y, Huang M, Fang W, Xu J, Yuan T, Xiao L, Tang YQ, Wang XD, Luo J, Yang W. Disrupting phosphorylation of Tyr-1070 at GluN2B selectively produces resilience to depression-like behaviors. Cell Reports. 36: 109612. PMID 34433031 DOI: 10.1016/j.celrep.2021.109612  0.632
2020 Xu L, Han Y, Chen X, Aierken A, Wen H, Zheng W, Wang H, Lu X, Zhao Z, Ma C, Liang P, Yang W, Yang S, Yang F. Molecular mechanisms underlying menthol binding and activation of TRPM8 ion channel. Nature Communications. 11: 3790. PMID 32728032 DOI: 10.1038/S41467-020-17582-X  0.312
2020 Wang M, Li J, Dong S, Cai X, Simaiti A, Yang X, Zhu X, Luo J, Jiang LH, Du B, Yu P, Yang W. Silica nanoparticles induce lung inflammation in mice via ROS/PARP/TRPM2 signaling-mediated lysosome impairment and autophagy dysfunction. Particle and Fibre Toxicology. 17: 23. PMID 32513195 DOI: 10.1186/S12989-020-00353-3  0.527
2019 Luo YH, Yu XF, Ma C, Yang F, Yang W. Effects of calcium-binding sites in the S2-S3 loop on human and Nematostella vectensis TRPM2 channel gating processes. Journal of Zhejiang University. Science. B. 20: 972-982. PMID 31749344 DOI: 10.1631/Jzus.B1900477  0.309
2019 Yu P, Liu Z, Yu X, Ye P, Liu H, Xue X, Yang L, Li Z, Wu Y, Fang C, Zhao YJ, Yang F, Luo JH, Jiang LH, Zhang L, ... ... Yang W, et al. Direct Gating of the TRPM2 Channel by cADPR via Specific Interactions with the ADPR Binding Pocket. Cell Reports. 27: 3684-3695.e4. PMID 31216484 DOI: 10.1016/J.Celrep.2019.05.067  0.341
2018 Yang F, Xiao X, Lee BH, Vu S, Yang W, Yarov-Yarovoy V, Zheng J. The conformational wave in capsaicin activation of transient receptor potential vanilloid 1 ion channel. Nature Communications. 9: 2879. PMID 30038260 DOI: 10.1016/J.Bpj.2018.11.2439  0.317
2018 Luo Y, Yu X, Ma C, Luo J, Yang W. Identification of a Novel EF-Loop in the N-terminus of TRPM2 Channel Involved in Calcium Sensitivity. Frontiers in Pharmacology. 9: 581. PMID 29915540 DOI: 10.3389/Fphar.2018.00581  0.584
2018 Wang J, Lv X, Wu Y, Xu T, Jiao M, Yang R, Li X, Chen M, Yan Y, Chen C, Dong W, Yang W, Zhuo M, Chen T, Luo J, et al. Postsynaptic RIM1 modulates synaptic function by facilitating membrane delivery of recycling NMDARs in hippocampal neurons. Nature Communications. 9: 2267. PMID 29891949 DOI: 10.1038/S41467-018-04672-0  0.594
2018 Zhang H, Liu H, Luo X, Wang Y, Liu Y, Jin H, Liu Z, Yang W, Yu P, Zhang L, Zhang L. Design, synthesis and biological activities of 2,3-dihydroquinazolin-4(1H)-one derivatives as TRPM2 inhibitors. European Journal of Medicinal Chemistry. 152: 235-252. PMID 29723786 DOI: 10.1016/J.Ejmech.2018.04.045  0.316
2017 Li X, Yang W, Jiang LH. Alteration in Intracellular Zn2+ Homeostasis as a Result of TRPM2 Channel Activation Contributes to ROS-Induced Hippocampal Neuronal Death. Frontiers in Molecular Neuroscience. 10: 414. PMID 29311807 DOI: 10.3389/Fnmol.2017.00414  0.34
2017 Liu Q, Shen Y, Cao X, Li Y, Chen Y, Yang W, Yuan TF. Either at left or right, both high and low frequency rTMS of dorsolateral prefrontal cortex decreases cue induced craving for methamphetamine. The American Journal On Addictions. PMID 29134789 DOI: 10.1111/ajad.12638  0.379
2017 Luo X, Li M, Zhan K, Yang W, Zhang L, Wang K, Yu P, Zhang L. Selective inhibition of TRPM2 channel by two novel synthesized ADPR analogues. Chemical Biology & Drug Design. PMID 29034580 DOI: 10.1111/Cbdd.13119  0.304
2017 Xu XX, Liu XR, Fan CY, Lai JX, Shi YW, Yang W, Su T, Xu JY, Luo JH, Liao WP. Functional Investigation of a GRIN2A Variant Associated with Rolandic Epilepsy. Neuroscience Bulletin. PMID 28936771 DOI: 10.1007/S12264-017-0182-6  0.564
2017 Yuan Y, Zheng Y, Zhang X, Chen Y, Wu X, Wu J, Shen Z, Jiang L, Wang L, Yang W, Luo J, Qin Z, Hu W, Chen Z. BNIP3L/NIX-mediated mitophagy protects against ischemic brain injury independent of PARK2. Autophagy. 0. PMID 28820284 DOI: 10.1080/15548627.2017.1357792  0.539
2017 Jiang Q, Gao Y, Wang C, Tao RR, Wu Y, Zhan K, Liao MH, Lu N, Lu YM, Wilcox CS, Luo J, Jiang LH, Yang W, Han F. Nitration of TRPM2 as a Molecular Switch Induces Autophagy during Brain Pericyte Injury. Antioxidants & Redox Signaling. PMID 28292196 DOI: 10.1089/ars.2016.6873  0.495
2017 Yu P, Xue X, Zhang J, Hu X, Wu Y, Jiang LH, Jin H, Luo J, Zhang L, Liu Z, Yang W. Identification of the ADPR binding pocket in the NUDT9 homology domain of TRPM2. The Journal of General Physiology. PMID 28108595 DOI: 10.1085/Jgp.201611675  0.556
2016 Yan X, Zhang B, Lu W, Peng L, Yang Q, Cao W, Lin S, Yu W, Li X, Ke Y, Li S, Yang W, Luo J. Increased Src Family Kinase Activity Disrupts Excitatory Synaptic Transmission and Impairs Remote Fear Memory in Forebrain Shp2-Deficient Mice. Molecular Neurobiology. PMID 27796759 DOI: 10.1007/S12035-016-0222-7  0.721
2016 Zhang B, Du YL, Lu W, Yan XY, Yang Q, Yang W, Luo JH. Increased Activity of Src Homology 2 Domain Containing Phosphotyrosine Phosphatase 2 (Shp2) Regulates Activity Dependent AMPA Receptor Trafficking. The Journal of Biological Chemistry. PMID 27417137 DOI: 10.1074/Jbc.M116.714501  0.6
2016 Zhan KY, Yu PL, Liu CH, Luo JH, Yang W. Detrimental or beneficial: the role of TRPM2 in ischemia/reperfusion injury. Acta Pharmacologica Sinica. 37: 4-12. PMID 26725732 DOI: 10.1038/Aps.2015.141  0.535
2015 Yu P, Li J, Jiang J, Zhao Z, Hui Z, Zhang J, Zheng Y, Ling D, Wang L, Jiang LH, Luo J, Zhu X, Yang W. A dual role of transient receptor potential melastatin 2 channel in cytotoxicity induced by silica nanoparticles. Scientific Reports. 5: 18171. PMID 26656285 DOI: 10.1038/Srep18171  0.574
2015 Lu W, Fang W, Li J, Zhang B, Yang Q, Yan X, Peng L, Ai H, Wang JJ, Liu X, Luo J, Yang W. Phosphorylation of tyrosine Y1070 at the GluN2B subunit is regulated by synaptic activity and critical for surface expression of NMDA receptors. The Journal of Biological Chemistry. PMID 26229100 DOI: 10.1074/Jbc.M115.663450  0.598
2015 Zhang XM, Yan XY, Zhang B, Yang Q, Ye M, Cao W, Qiang WB, Zhu LJ, Du YL, Xu XX, Wang JS, Xu F, Lu W, Qiu S, Yang W, et al. Activity-induced synaptic delivery of the GluN2A-containing NMDA receptor is dependent on endoplasmic reticulum chaperone Bip and involved in fear memory. Cell Research. 25: 818-36. PMID 26088419 DOI: 10.1038/Cr.2015.75  0.609
2015 Chen P, Wu JZ, Zhao J, Wang P, Luo J, Yang W, Liu XD. PKD2L1/PKD1L3 channel complex with an alkali-activated mechanism and calcium-dependent inactivation. European Biophysics Journal : Ebj. PMID 26066678 DOI: 10.1007/s00249-015-1040-y  0.524
2015 Yang F, Xiao X, Cheng W, Yang W, Yu P, Song Z, Yarov-Yarovoy V, Zheng J. Structural mechanism underlying capsaicin binding and activation of the TRPV1 ion channel. Nature Chemical Biology. 11: 518-24. PMID 26053297 DOI: 10.1038/Nchembio.1835  0.302
2015 Yang F, Xiao X, Cheng W, Yang W, Yarov-Yarovoy V, Zheng J. Molecular Mechanism of TRPV1 Activation by Capsaicin Biophysical Journal. 108: 1-4. DOI: 10.1016/J.Bpj.2014.11.696  0.343
2014 Yu W, Jiang LH, Zheng Y, Hu X, Luo J, Yang W. Inactivation of TRPM2 channels by extracellular divalent copper. Plos One. 9: e112071. PMID 25386648 DOI: 10.1371/Journal.Pone.0112071  0.713
2013 Ai H, Lu W, Ye M, Yang W. Synaptic non-GluN2B-containing NMDA receptors regulate tyrosine phosphorylation of GluN2B 1472 tyrosine site in rat brain slices. Neuroscience Bulletin. 29: 614-20. PMID 23585298 DOI: 10.1007/S12264-013-1337-8  0.315
2012 Zhu J, Shao CY, Yang W, Zhang XM, Wu ZY, Zhou L, Wang XX, Li YH, Xia J, Luo JH, Shen Y. Chronic zinc exposure decreases the surface expression of NR2A-containing NMDA receptors in cultured hippocampal neurons. Plos One. 7: e46012. PMID 23049922 DOI: 10.1371/Journal.Pone.0046012  0.593
2011 Yang W, Manna PT, Zou J, Luo J, Beech DJ, Sivaprasadarao A, Jiang LH. Zinc inactivates melastatin transient receptor potential 2 channels via the outer pore. The Journal of Biological Chemistry. 286: 23789-98. PMID 21602277 DOI: 10.1016/J.Bpj.2011.11.1882  0.596
2011 Ai H, Yang W, Ye M, Lu W, Yao L, Luo JH. Differential regulation of AMPA receptor GluA1 phosphorylation at serine 831 and 845 associated with activation of NMDA receptor subpopulations. Neuroscience Letters. 497: 94-8. PMID 21539895 DOI: 10.1016/J.Neulet.2011.04.038  0.555
2010 Zhao J, Yang W, Luo JH. [TRPP subfamily and kidney diseases]. Zhejiang Da Xue Xue Bao. Yi Xue Ban = Journal of Zhejiang University. Medical Sciences. 39: 650-6. PMID 21166062  0.508
2010 Jiang LH, Yang W, Zou J, Beech DJ. TRPM2 channel properties, functions and therapeutic potentials. Expert Opinion On Therapeutic Targets. 14: 973-88. PMID 20670202 DOI: 10.1517/14728222.2010.510135  0.31
2010 Yang W, Zou J, Xia R, Vaal ML, Seymour VA, Luo J, Beech DJ, Jiang LH. State-dependent inhibition of TRPM2 channel by acidic pH. The Journal of Biological Chemistry. 285: 30411-8. PMID 20660597 DOI: 10.1074/Jbc.M110.139774  0.568
2009 Chen P, Liu XD, Zhang W, Zhou J, Wang P, Yang W, Luo J. Modeling and simulation of ion channels and action potentials in taste receptor cells. Science in China. Series C, Life Sciences / Chinese Academy of Sciences. 52: 1036-47. PMID 19937202 DOI: 10.1007/s11427-009-0138-9  0.528
2009 Qiu S, Zhang XM, Cao JY, Yang W, Yan YG, Shan L, Zheng J, Luo JH. An endoplasmic reticulum retention signal located in the extracellular amino-terminal domain of the NR2A subunit of N-Methyl-D-aspartate receptors. The Journal of Biological Chemistry. 284: 20285-98. PMID 19487695 DOI: 10.1074/Jbc.M109.004960  0.599
2008 Xia R, Mei ZZ, Mao HJ, Yang W, Dong L, Bradley H, Beech DJ, Jiang LH. Identification of pore residues engaged in determining divalent cationic permeation in transient receptor potential melastatin subtype channel 2. The Journal of Biological Chemistry. 283: 27426-32. PMID 18687688 DOI: 10.1074/Jbc.M801049200  0.319
2007 Ning W, Xu SJ, Chiang H, Xu ZP, Zhou SY, Yang W, Luo JH. Effects of GSM 1800 MHz on dendritic development of cultured hippocampal neurons. Acta Pharmacologica Sinica. 28: 1873-80. PMID 18031599 DOI: 10.1111/J.1745-7254.2007.00668.X  0.493
2007 Yang W, Zheng C, Song Q, Yang X, Qiu S, Liu C, Chen Z, Duan S, Luo J. A three amino acid tail following the TM4 region of the N-methyl-D-aspartate receptor (NR) 2 subunits is sufficient to overcome endoplasmic reticulum retention of NR1-1a subunit. The Journal of Biological Chemistry. 282: 9269-78. PMID 17255096 DOI: 10.1074/Jbc.M700050200  0.581
2003 Yang W, Luo JH, Gao Y, Huang M, Zheng CY. [Construction of expression vectors for C-terminally deleted NR2B subunit mutants and their application in the study of assembling of NMDA receptors]. Zhejiang Da Xue Xue Bao. Yi Xue Ban = Journal of Zhejiang University. Medical Sciences. 32: 480-5. PMID 14712509  0.523
2003 Zheng CY, Luo JH, Fu T, Yang W, Shen HQ. [Surface expression of NMDA receptors composed of NR1 subunit and NR2A subunit mutants with partially deleted C-terminus in HEK293 cells]. Zhejiang Da Xue Xue Bao. Yi Xue Ban = Journal of Zhejiang University. Medical Sciences. 32: 475-9. PMID 14712508  0.537
2003 Huang M, Luo JH, Wang W, Qiu S, Yang W, Fu ZY. [Surface expression and co-localization of NMDA receptor and AMPA receptor on dendritic tree of hippocampal neurons in culture]. Zhejiang Da Xue Xue Bao. Yi Xue Ban = Journal of Zhejiang University. Medical Sciences. 32: 470-4. PMID 14712507  0.528
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