Dorian B. McGavern, Ph.D. - Publications

Affiliations: 
Mayo Clinic, Rochester, MN, United States 
 Scripps Research Institute, La Jolla, La Jolla, CA, United States 
 National Institutes of Health-NINDS 

63 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2019 Riggle BA, Manglani M, Maric D, Johnson KR, Lee MH, Lopes Abath Neto O, Taylor TE, Seydel KB, Nath A, Miller LH, McGavern DB, Pierce SK. CD8+ T cells target cerebrovasculature in children with cerebral malaria. The Journal of Clinical Investigation. PMID 31821175 DOI: 10.1172/JCI133474  1
2019 Tiwari R, de la Torre JC, McGavern DB, Nayak D. Beyond Tethering the Viral Particles: Immunomodulatory Functions of Tetherin (). Dna and Cell Biology. PMID 31502877 DOI: 10.1089/dna.2019.4777  1
2019 Yao C, Sun HW, Lacey NE, Ji Y, Moseman EA, Shih HY, Heuston EF, Kirby M, Anderson S, Cheng J, Khan O, Handon R, Reilley J, Fioravanti J, Hu J, ... ... McGavern DB, et al. Single-cell RNA-seq reveals TOX as a key regulator of CD8 T cell persistence in chronic infection. Nature Immunology. PMID 31209400 DOI: 10.1038/s41590-019-0403-4  1
2019 Rua R, Lee JY, Silva AB, Swafford IS, Maric D, Johnson KR, McGavern DB. Infection drives meningeal engraftment by inflammatory monocytes that impairs CNS immunity. Nature Immunology. PMID 30886419 DOI: 10.1038/s41590-019-0344-y  0.36
2019 Manglani M, Rua R, Hendricksen A, Braunschweig D, Gao Q, Tan W, Houser B, McGavern DB, Oh K. Method to Quantify Cytokines and Chemokines in Mouse Brain Tissue Using Bio-Plex Multiplex Immunoassays. Methods (San Diego, Calif.). PMID 30742997 DOI: 10.1016/j.ymeth.2019.02.007  1
2018 Preite S, Huang B, Cannons JL, McGavern DB, Schwartzberg PL. PI3K Orchestrates T Follicular Helper Cell Differentiation in a Context Dependent Manner: Implications for Autoimmunity. Frontiers in Immunology. 9: 3079. PMID 30666254 DOI: 10.3389/fimmu.2018.03079  0.32
2018 Manglani M, Gossa S, McGavern DB. Leukocyte Isolation from Brain, Spinal Cord, and Meninges for Flow Cytometric Analysis. Current Protocols in Immunology. 121: e44. PMID 30040211 DOI: 10.1002/cpim.44  1
2018 Manglani M, McGavern DB. Intravital Imaging of Neuroimmune Interactions Through a Thinned Skull. Current Protocols in Immunology. 120: 24.2.1-24.2.12. PMID 29512146 DOI: 10.1002/cpim.46  1
2018 Manglani M, McGavern DB. New advances in CNS immunity against viral infection. Current Opinion in Virology. 28: 116-126. PMID 29289900 DOI: 10.1016/j.coviro.2017.12.003  1
2017 Pandya H, Shen MJ, Ichikawa DM, Sedlock AB, Choi Y, Johnson KR, Kim G, Brown MA, Elkahloun AG, Maric D, Sweeney CL, Gossa S, Malech HL, McGavern DB, Park JK. Differentiation of human and murine induced pluripotent stem cells to microglia-like cells. Nature Neuroscience. PMID 28253233 DOI: 10.1038/nn.4534  1
2016 Wu T, Ji Y, Moseman EA, Xu HC, Manglani M, Kirby M, Anderson SM, Handon R, Kenyon E, Elkahloun A, Wu W, Lang PA, Gattinoni L, McGavern DB, Schwartzberg PL. The TCF1-Bcl6 axis counteracts type I interferon to repress exhaustion and maintain T cell stemness. Science Immunology. 1. PMID 28018990 DOI: 10.1126/sciimmunol.aai8593  1
2016 Swanson PA, Hart GT, Russo MV, Nayak D, Yazew T, Peña M, Khan SM, Janse CJ, Pierce SK, McGavern DB. CD8+ T Cells Induce Fatal Brainstem Pathology during Cerebral Malaria via Luminal Antigen-Specific Engagement of Brain Vasculature. Plos Pathogens. 12: e1006022. PMID 27907215 DOI: 10.1371/journal.ppat.1006022  1
2016 Moseman EA, Wu T, de la Torre JC, Schwartzberg PL, McGavern DB. Type I interferon suppresses virus-specific B cell responses by modulating CD8(+) T cell differentiation. Science Immunology. 1. PMID 27812556  0.8
2016 Konradt C, Ueno N, Christian DA, Delong JH, Pritchard GH, Herz J, Bzik DJ, Koshy AA, McGavern DB, Lodoen MB, Hunter CA. Endothelial cells are a replicative niche for entry of Toxoplasma gondii to the central nervous system. Nature Microbiology. 1: 16001. PMID 27572166 DOI: 10.1038/nmicrobiol.2016.1  0.72
2015 Wu T, Shin HM, Moseman EA, Ji Y, Huang B, Harly C, Sen JM, Berg LJ, Gattinoni L, McGavern DB, Schwartzberg PL. TCF1 Is Required for the T Follicular Helper Cell Response to Viral Infection. Cell Reports. PMID 26365183 DOI: 10.1016/j.celrep.2015.08.049  0.8
2015 Wan CK, Andraski AB, Spolski R, Li P, Kazemian M, Oh J, Samsel L, Swanson PA, McGavern DB, Sampaio EP, Freeman AF, Milner JD, Holland SM, Leonard WJ. Opposing roles of STAT1 and STAT3 in IL-21 function in CD4+ T cells. Proceedings of the National Academy of Sciences of the United States of America. 112: 9394-9. PMID 26170288 DOI: 10.1073/pnas.1511711112  0.88
2015 Torchia ML, Munitic I, Castro E, Herz J, McGavern DB, Ashwell JD. c-IAP ubiquitin protein ligase activity is required for 4-1BB signaling and CD8(+) memory T-cell survival. European Journal of Immunology. PMID 26096449 DOI: 10.1002/eji.201445342  1
2015 Cardoso FL, Herz J, Fernandes A, Rocha J, Sepodes B, Brito MA, McGavern DB, Brites D. Systemic inflammation in early neonatal mice induces transient and lasting neurodegenerative effects. Journal of Neuroinflammation. 12: 82. PMID 25924675 DOI: 10.1186/s12974-015-0299-3  1
2015 Swanson PA, McGavern DB. Viral diseases of the central nervous system. Current Opinion in Virology. 11: 44-54. PMID 25681709 DOI: 10.1016/j.coviro.2014.12.009  1
2015 Corps KN, Roth TL, McGavern DB. Inflammation and neuroprotection in traumatic brain injury. Jama Neurology. 72: 355-62. PMID 25599342 DOI: 10.1001/jamaneurol.2014.3558  1
2014 Gossa S, Nayak D, Zinselmeyer BH, McGavern DB. Development of an immunologically tolerated combination of fluorescent proteins for in vivo two-photon imaging. Scientific Reports. 4: 6664. PMID 25322934 DOI: 10.1038/srep06664  1
2014 Nayak D, Roth TL, McGavern DB. Microglia development and function. Annual Review of Immunology. 32: 367-402. PMID 24471431 DOI: 10.1146/annurev-immunol-032713-120240  1
2014 Roth TL, Nayak D, Atanasijevic T, Koretsky AP, Latour LL, McGavern DB. Transcranial amelioration of inflammation and cell death after brain injury. Nature. 505: 223-8. PMID 24317693 DOI: 10.1038/nature12808  1
2013 Moseman EA, McGavern DB. The great balancing act: regulation and fate of antiviral T-cell interactions. Immunological Reviews. 255: 110-24. PMID 23947351 DOI: 10.1111/imr.12093  0.8
2013 Nayak D, Johnson KR, Heydari S, Roth TL, Zinselmeyer BH, McGavern DB. Type I interferon programs innate myeloid dynamics and gene expression in the virally infected nervous system. Plos Pathogens. 9: e1003395. PMID 23737750 DOI: 10.1371/journal.ppat.1003395  1
2013 Navarathna DH, Munasinghe J, Lizak MJ, Nayak D, McGavern DB, Roberts DD. MRI confirms loss of blood-brain barrier integrity in a mouse model of disseminated candidiasis. Nmr in Biomedicine. 26: 1125-34. PMID 23606437 DOI: 10.1002/nbm.2926  1
2013 Zinselmeyer BH, Heydari S, Sacristán C, Nayak D, Cammer M, Herz J, Cheng X, Davis SJ, Dustin ML, McGavern DB. PD-1 promotes immune exhaustion by inducing antiviral T cell motility paralysis. The Journal of Experimental Medicine. 210: 757-74. PMID 23530125 DOI: 10.1084/jem.20121416  1
2012 Nayak D, Zinselmeyer BH, Corps KN, McGavern DB. In vivo dynamics of innate immune sentinels in the CNS. Intravital. 1: 95-106. PMID 24078900 DOI: 10.4161/intv.22823  1
2012 Oldstone MB, Edelmann KH, McGavern DB, Cruite JT, Welch MJ. Molecular anatomy and number of antigen specific CD8 T cells required to cause type 1 diabetes. Plos Pathogens. 8: e1003044. PMID 23209415 DOI: 10.1371/journal.ppat.1003044  1
2012 Herz J, Zinselmeyer BH, McGavern DB. Two-photon imaging of microbial immunity in living tissues. Microscopy and Microanalysis : the Official Journal of Microscopy Society of America, Microbeam Analysis Society, Microscopical Society of Canada. 18: 730-41. PMID 22846498 DOI: 10.1017/S1431927612000281  1
2012 Garidou L, Heydari S, Gossa S, McGavern DB. Therapeutic blockade of transforming growth factor beta fails to promote clearance of a persistent viral infection. Journal of Virology. 86: 7060-71. PMID 22553324 DOI: 10.1128/JVI.00164-12  1
2011 Fahey LM, Wilson EB, Elsaesser H, Fistonich CD, McGavern DB, Brooks DG. Viral persistence redirects CD4 T cell differentiation toward T follicular helper cells. The Journal of Experimental Medicine. 208: 987-99. PMID 21536743 DOI: 10.1084/jem.20101773  1
2011 McGavern DB, Kang SS. Illuminating viral infections in the nervous system. Nature Reviews. Immunology. 11: 318-29. PMID 21508982 DOI: 10.1038/nri2971  1
2011 Kang SS, Herz J, Kim JV, Nayak D, Stewart-Hutchinson P, Dustin ML, McGavern DB. Migration of cytotoxic lymphocytes in cell cycle permits local MHC I-dependent control of division at sites of viral infection. The Journal of Experimental Medicine. 208: 747-59. PMID 21464219 DOI: 10.1084/jem.20101295  1
2010 Kang SS, McGavern DB. Microbial induction of vascular pathology in the CNS. Journal of Neuroimmune Pharmacology : the Official Journal of the Society On Neuroimmune Pharmacology. 5: 370-86. PMID 20401700 DOI: 10.1007/s11481-010-9208-9  1
2009 Truong P, Heydari S, Garidou L, McGavern DB. Persistent viral infection elevates central nervous system MHC class I through chronic production of interferons. Journal of Immunology (Baltimore, Md. : 1950). 183: 3895-905. PMID 19717517 DOI: 10.4049/jimmunol.0803085  1
2009 Garidou L, Heydari S, Truong P, Brooks DG, McGavern DB. Therapeutic memory T cells require costimulation for effective clearance of a persistent viral infection. Journal of Virology. 83: 8905-15. PMID 19553326 DOI: 10.1128/JVI.00027-09  1
2009 Kang SS, McGavern DB. Inflammation on the mind: visualizing immunity in the central nervous system. Current Topics in Microbiology and Immunology. 334: 227-63. PMID 19521688 DOI: 10.1007/978-3-540-93864-4_10  1
2009 Emonet SF, Garidou L, McGavern DB, de la Torre JC. Generation of recombinant lymphocytic choriomeningitis viruses with trisegmented genomes stably expressing two additional genes of interest. Proceedings of the National Academy of Sciences of the United States of America. 106: 3473-8. PMID 19208813 DOI: 10.1073/pnas.0900088106  0.52
2009 Kim JV, Kang SS, Dustin ML, McGavern DB. Myelomonocytic cell recruitment causes fatal CNS vascular injury during acute viral meningitis. Nature. 457: 191-5. PMID 19011611 DOI: 10.1038/nature07591  1
2008 Truong P, McGavern DB. A novel virus carrier state to evaluate immunotherapeutic regimens: regulatory T cells modulate the pathogenicity of antiviral memory cells. Journal of Immunology (Baltimore, Md. : 1950). 181: 1161-9. PMID 18606669  1
2008 Kang SS, McGavern DB. Lymphocytic choriomeningitis infection of the central nervous system. Frontiers in Bioscience : a Journal and Virtual Library. 13: 4529-43. PMID 18508527 DOI: 10.2741/3021  1
2008 Brooks DG, Lee AM, Elsaesser H, McGavern DB, Oldstone MB. IL-10 blockade facilitates DNA vaccine-induced T cell responses and enhances clearance of persistent virus infection. The Journal of Experimental Medicine. 205: 533-41. PMID 18332180 DOI: 10.1084/jem.20071948  0.72
2007 Lauterbach H, Truong P, McGavern DB. Clearance of an immunosuppressive virus from the CNS coincides with immune reanimation and diversification. Virology Journal. 4: 53. PMID 17553158 DOI: 10.1186/1743-422X-4-53  1
2006 Brooks DG, Trifilo MJ, Edelmann KH, Teyton L, McGavern DB, Oldstone MB. Interleukin-10 determines viral clearance or persistence in vivo. Nature Medicine. 12: 1301-9. PMID 17041596 DOI: 10.1038/nm1492  0.72
2006 Kunz S, Rojek JM, Roberts AJ, McGavern DB, Oldstone MB, de la Torre JC. Altered central nervous system gene expression caused by congenitally acquired persistent infection with lymphocytic choriomeningitis virus. Journal of Virology. 80: 9082-92. PMID 16940520 DOI: 10.1128/JVI.00795-06  0.72
2006 Lauterbach H, Zuniga EI, Truong P, Oldstone MB, McGavern DB. Adoptive immunotherapy induces CNS dendritic cell recruitment and antigen presentation during clearance of a persistent viral infection. The Journal of Experimental Medicine. 203: 1963-75. PMID 16847068 DOI: 10.1084/jem.20060039  1
2006 Brooks DG, McGavern DB, Oldstone MB. Reprogramming of antiviral T cells prevents inactivation and restores T cell activity during persistent viral infection. The Journal of Clinical Investigation. 116: 1675-85. PMID 16710479 DOI: 10.1172/JCI26856  0.72
2005 Brooks DG, Teyton L, Oldstone MB, McGavern DB. Intrinsic functional dysregulation of CD4 T cells occurs rapidly following persistent viral infection. Journal of Virology. 79: 10514-27. PMID 16051844 DOI: 10.1128/JVI.79.16.10514-10527.2005  0.72
2005 Popkov M, Jendreyko N, McGavern DB, Rader C, Barbas CF. Targeting tumor angiogenesis with adenovirus-delivered anti-Tie-2 intrabody. Cancer Research. 65: 972-81. PMID 15705898  1
2004 Zuniga EI, McGavern DB, Pruneda-Paz JL, Teng C, Oldstone MB. Bone marrow plasmacytoid dendritic cells can differentiate into myeloid dendritic cells upon virus infection. Nature Immunology. 5: 1227-34. PMID 15531885 DOI: 10.1038/ni1136  0.72
2004 Christen U, Edelmann KH, McGavern DB, Wolfe T, Coon B, Teague MK, Miller SD, Oldstone MB, von Herrath MG. A viral epitope that mimics a self antigen can accelerate but not initiate autoimmune diabetes. The Journal of Clinical Investigation. 114: 1290-8. PMID 15520861 DOI: 10.1172/JCI22557  0.72
2004 McGavern DB, Truong P. Rebuilding an immune-mediated central nervous system disease: weighing the pathogenicity of antigen-specific versus bystander T cells. Journal of Immunology (Baltimore, Md. : 1950). 173: 4779-90. PMID 15470017  1
2004 Homann D, McGavern DB, Oldstone MB. Visualizing the viral burden: phenotypic and functional alterations of T cells and APCs during persistent infection. Journal of Immunology (Baltimore, Md. : 1950). 172: 6239-50. PMID 15128812  0.72
2004 Sevilla N, McGavern DB, Teng C, Kunz S, Oldstone MB. Viral targeting of hematopoietic progenitors and inhibition of DC maturation as a dual strategy for immune subversion. The Journal of Clinical Investigation. 113: 737-45. PMID 14991072 DOI: 10.1172/JCI20243  0.72
2004 Solforosi L, Criado JR, McGavern DB, Wirz S, Sánchez-Alavez M, Sugama S, DeGiorgio LA, Volpe BT, Wiseman E, Abalos G, Masliah E, Gilden D, Oldstone MB, Conti B, Williamson RA. Cross-linking cellular prion protein triggers neuronal apoptosis in vivo. Science (New York, N.Y.). 303: 1514-6. PMID 14752167 DOI: 10.1126/science.1094273  1
2003 Christen U, McGavern DB, Luster AD, von Herrath MG, Oldstone MB. Among CXCR3 chemokines, IFN-gamma-inducible protein of 10 kDa (CXC chemokine ligand (CXCL) 10) but not monokine induced by IFN-gamma (CXCL9) imprints a pattern for the subsequent development of autoimmune disease. Journal of Immunology (Baltimore, Md. : 1950). 171: 6838-45. PMID 14662890  0.72
2003 Jendreyko N, Popkov M, Beerli RR, Chung J, McGavern DB, Rader C, Barbas CF. Intradiabodies, bispecific, tetravalent antibodies for the simultaneous functional knockout of two cell surface receptors. The Journal of Biological Chemistry. 278: 47812-9. PMID 12947084 DOI: 10.1074/jbc.M307002200  1
2003 Zoecklein LJ, Pavelko KD, Gamez J, Papke L, McGavern DB, Ure DR, Njenga MK, Johnson AJ, Nakane S, Rodriguez M. Direct comparison of demyelinating disease induced by the Daniel's strain and BeAn strain of Theiler's murine encephalomyelitis virus. Brain Pathology (Zurich, Switzerland). 13: 291-308. PMID 12946019  0.52
2002 McGavern DB, Homann D, Oldstone MB. T cells in the central nervous system: the delicate balance between viral clearance and disease. The Journal of Infectious Diseases. 186: S145-51. PMID 12424690 DOI: 10.1086/344264  0.72
2002 McGavern DB, Christen U, Oldstone MB. Molecular anatomy of antigen-specific CD8(+) T cell engagement and synapse formation in vivo. Nature Immunology. 3: 918-25. PMID 12352968 DOI: 10.1038/ni843  0.72
2002 Murray PD, McGavern DB, Pease LR, Rodriguez M. Cellular sources and targets of IFN-gamma-mediated protection against viral demyelination and neurological deficits. European Journal of Immunology. 32: 606-15. PMID 11857334 DOI: 10.1002/1521-4141(200203)32:3<606::AID-IMMU606>3.0.CO;2-D  1
1997 Horwitz MS, Evans CF, McGavern DB, Rodriguez M, Oldstone MB. Primary demyelination in transgenic mice expressing interferon-gamma. Nature Medicine. 3: 1037-41. PMID 9288735  0.72
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