| Year |
Citation |
Score |
| 2023 |
El Bakali J, Blaszczyk M, Evans JC, Boland JA, McCarthy WJ, Fathoni I, Dias MVB, Johnson EO, Coyne AG, Mizrahi V, Blundell TL, Abell C, Spry C. Chemical Validation of Mycobacterium tuberculosis Phosphopantetheine Adenylyltransferase Using Fragment Linking and CRISPR Interference. Angewandte Chemie (International Ed. in English). PMID 36757665 DOI: 10.1002/anie.202300221 |
0.311 |
|
| 2022 |
Bedwell E, McCarthy WJ, Coyne AG, Abell C. Development of potent inhibitors by fragment-linking strategies. Chemical Biology & Drug Design. PMID 35854428 DOI: 10.1111/cbdd.14120 |
0.302 |
|
| 2022 |
Thomas SE, McCarthy WJ, El Bakali J, Brown KP, Kim SY, Blaszczyk M, Mendes V, Abell C, Floto RA, Coyne AG, Blundell TL. Structural Characterization of Phosphopantetheine Adenylyl Transferase Ligand Interactions: Implications for Fragment-Based Drug Design. Frontiers in Molecular Biosciences. 9: 880432. PMID 35712348 DOI: 10.3389/fmolb.2022.880432 |
0.315 |
|
| 2022 |
Acebrón-García-de-Eulate M, Mayol-Llinàs J, Holland MTO, Kim SY, Brown KP, Marchetti C, Hess J, Di Pietro O, Mendes V, Abell C, Floto RA, Coyne AG, Blundell TL. Discovery of Novel Inhibitors of Uridine Diphosphate--Acetylenolpyruvylglucosamine Reductase (MurB) from , an Opportunistic Infectious Agent Causing Death in Cystic Fibrosis Patients. Journal of Medicinal Chemistry. PMID 35080396 DOI: 10.1021/acs.jmedchem.1c01684 |
0.307 |
|
| 2022 |
Frederickson M, Selvam IR, Evangelopoulos D, McLean KJ, Katariya MM, Tunnicliffe RB, Campbell B, Kavanagh ME, Charoensutthivarakul S, Blankley RT, Levy CW, de Carvalho LPS, Leys D, Munro AW, Coyne AG, et al. A new strategy for hit generation: Novel in cellulo active inhibitors of CYP121A1 from Mycobacterium tuberculosis via a combined X-ray crystallographic and phenotypic screening approach (XP screen). European Journal of Medicinal Chemistry. 230: 114105. PMID 35065413 DOI: 10.1016/j.ejmech.2022.114105 |
0.748 |
|
| 2022 |
Charoensutthivarakul S, Thomas SE, Curran A, Brown KP, Belardinelli JM, Whitehouse AJ, Acebrón-García-de-Eulate M, Sangan J, Gramani SG, Jackson M, Mendes V, Floto RA, Blundell TL, Coyne AG, Abell C. Development of Inhibitors of SAICAR Synthetase (PurC) from Using a Fragment-Based Approach. Acs Infectious Diseases. PMID 35037462 DOI: 10.1021/acsinfecdis.1c00432 |
0.76 |
|
| 2021 |
Scott DE, Francis-Newton NJ, Marsh ME, Coyne AG, Fischer G, Moschetti T, Bayly AR, Sharpe TD, Haas KT, Barber L, Valenzano CR, Srinivasan R, Huggins DJ, Lee M, Emery A, et al. A small-molecule inhibitor of the BRCA2-RAD51 interaction modulates RAD51 assembly and potentiates DNA damage-induced cell death. Cell Chemical Biology. PMID 33662256 DOI: 10.1016/j.chembiol.2021.02.006 |
0.724 |
|
| 2020 |
Sabbah M, Mendes V, Vistal RG, Dias DMG, Záhorszká M, Mikušová K, Korduláková J, Coyne AG, Blundell TL, Abell C. Correction to Fragment-Based Design of InhA Inhibitors. Journal of Medicinal Chemistry. PMID 32697583 DOI: 10.1021/Acs.Jmedchem.0C01187 |
0.5 |
|
| 2020 |
Ribeiro JA, Hammer AJS, Libreros-Z Uacute Ntilde Iga GAES, Chavez-Pacheco SM, Tyrakis P, de Oliveira GS, Kirkman T, El Bakali J, Rocco SA, Sforça ML, Parise Filho R, Coyne AG, Blundell TL, Abell C, Dias MVB. Using a fragment-based approach to identify alternative chemical scaffolds targeting dihydrofolate reductase from Mycobacterium tuberculosis. Acs Infectious Diseases. PMID 32603583 DOI: 10.1021/Acsinfecdis.0C00263 |
0.591 |
|
| 2020 |
Thomas SE, Whitehouse AJ, Brown K, Burbaud S, Belardinelli JM, Sangen J, Lahiri R, Libardo MDJ, Gupta P, Malhotra S, Boshoff HIM, Jackson M, Abell C, Coyne AG, Blundell TL, et al. Fragment-based discovery of a new class of inhibitors targeting mycobacterial tRNA modification. Nucleic Acids Research. PMID 32602532 DOI: 10.1093/Nar/Gkaa539 |
0.574 |
|
| 2020 |
Sabbah M, Mendes V, Vistal RG, Dias DM, Záhorszká M, Mikušová K, Korduláková J, Coyne AG, Blundell TL, Abell C. Fragment-based design of Mycobacterium tuberculosis InhA inhibitors. Journal of Medicinal Chemistry. PMID 32240584 DOI: 10.1021/Acs.Jmedchem.0C00007 |
0.577 |
|
| 2019 |
Trapero A, Pacitto A, Chan DS, Abell C, Blundell TL, Ascher DB, Coyne AG. Covalent inactivation of Mycobacterium thermoresistibile inosine-5'-monophosphate dehydrogenase (IMPDH). Bioorganic & Medicinal Chemistry Letters. 126792. PMID 31757668 DOI: 10.1016/J.Bmcl.2019.126792 |
0.718 |
|
| 2019 |
Panicker RC, Chattopadhaya S, Coyne AG, Srinivasan R. Allosteric Small-Molecule Serine/Threonine Kinase Inhibitors. Advances in Experimental Medicine and Biology. 1163: 253-278. PMID 31707707 DOI: 10.1007/978-981-13-8719-7_11 |
0.706 |
|
| 2019 |
Whitehouse AJ, Libardo MDJ, Kasbekar M, Brear PD, Fischer G, Thomas CJ, Barry C, Boshoff HIM, Coyne AG, Abell C. Targeting of fumarate hydratase from Mycobacterium tuberculosis using allosteric inhibitors with a dimeric-binding mode. Journal of Medicinal Chemistry. PMID 31517489 DOI: 10.1021/Acs.Jmedchem.9B01203 |
0.567 |
|
| 2019 |
Chan DS, Hess J, Shaw E, Spry C, Starley R, Dagostin C, Dias MV, Kale R, Mendes V, Blundell TL, Coyne AG, Abell C. Structural Insights into Phosphopantothenoylcysteine Synthetase by Native Ion Mobility-Mass Spectrometry. The Biochemical Journal. PMID 31488574 DOI: 10.1042/Bcj20190318 |
0.709 |
|
| 2019 |
Whitehouse A, Thomas SE, Brown KP, Fanourakis A, Chan D, Libardo MDJ, Mendes V, Boshoff HIM, Floto RA, Abell C, Blundell TL, Coyne AG. Development of inhibitors against Mycobacterium abscessus tRNA (m1G37) methyltransferase (TrmD) using fragment-based approaches. Journal of Medicinal Chemistry. PMID 31282680 DOI: 10.1021/Acs.Jmedchem.9B00809 |
0.538 |
|
| 2019 |
Thomas SE, Collins P, James RH, Mendes V, Charoensutthivarakul S, Radoux C, Abell C, Coyne AG, Floto RA, von Delft F, Blundell TL. Structure-guided fragment-based drug discovery at the synchrotron: screening binding sites and correlations with hotspot mapping. Philosophical Transactions. Series a, Mathematical, Physical, and Engineering Sciences. 377: 20180422. PMID 31030650 DOI: 10.1098/Rsta.2018.0422 |
0.782 |
|
| 2019 |
Li X, Deng X, Coyne AG, Srinivasan R. Meta-Nitration of Arenes Bearing Ortho/Para Directing Group(s) via C-H Borylation. Chemistry (Weinheim An Der Bergstrasse, Germany). PMID 30974007 DOI: 10.1002/Chem.201901633 |
0.694 |
|
| 2018 |
Trapero A, Pacitto A, Singh V, Sabbah M, Coyne AG, Mizrahi V, Blundell TL, Ascher DB, Abell C. A fragment-based approach to targeting inosine-5´-monophosphate dehydrogenase (IMPDH) from Mycobacterium tuberculosis. Journal of Medicinal Chemistry. PMID 29547284 DOI: 10.1021/Acs.Jmedchem.7B01622 |
0.617 |
|
| 2017 |
Chan DS, Whitehouse AJ, Coyne AG, Abell C. Mass spectrometry for fragment screening. Essays in Biochemistry. PMID 28986384 DOI: 10.1042/Ebc20170071 |
0.716 |
|
| 2017 |
Chan DS, Kavanagh MEE, McLean KJ, Munro AW, Matak-Vinkovic D, Coyne AG, Abell C. Effect of DMSO on Protein Structure and Interactions Assessed By Collision-induced Dissociation and Unfolding. Analytical Chemistry. PMID 28803470 DOI: 10.1021/Acs.Analchem.7B02329 |
0.498 |
|
| 2017 |
Panicker RC, Coyne AG, Srinivasan R. Allosteric Targeting of Aurora A Kinase Using Small Molecules: A Step Forward Towards Next Generation Medicines? Current Medicinal Chemistry. PMID 28748768 DOI: 10.2174/0929867324666170727120315 |
0.722 |
|
| 2017 |
Chan DS, Mendes V, Thomas SE, McConnell BN, Matak-Vinković D, Coyne AG, Blundell TL, Abell C. Fragment screening against the EthR-DNA interaction by native mass spectrometry. Angewandte Chemie (International Ed. in English). PMID 28513917 DOI: 10.1002/Anie.201702888 |
0.717 |
|
| 2017 |
Shiu-Hin Chan D, Seetoh WG, McConnell BN, Matak-Vinković D, Thomas SE, Mendes V, Blaszczyk M, Coyne AG, Blundell TL, Abell C. Structural insights into the EthR-DNA interaction using native mass spectrometry. Chemical Communications (Cambridge, England). PMID 28287239 DOI: 10.1039/C7Cc00804J |
0.514 |
|
| 2017 |
Kavanagh ME, Chenge J, Zoufir A, McLean KJ, Coyne AG, Bender A, Munro AW, Abell C. A fragment profiling approach to inhibitors of the orphan M. tuberculosis P450 CYP144A1. Biochemistry. PMID 28169518 DOI: 10.1021/Acs.Biochem.6B00954 |
0.558 |
|
| 2017 |
Kavanagh ME, Gray JL, Gilbert SH, Coyne AG, McLean KJ, Davis HJ, Munro AW, Abell C. Corrigendum: Substrate Fragmentation for the Design of M. tuberculosis CYP121 Inhibitors. Chemmedchem. 12: 194-195. PMID 28112499 DOI: 10.1002/Cmdc.201600619 |
0.512 |
|
| 2016 |
Chenge JT, Le DV, Swami S, McLean KJ, Kavanagh ME, Coyne AG, Rigby SE, Cheesman MR, Girvan HM, Levy CW, Rupp B, von Kries JP, Abell C, Leys D, Munro AW. Structural Characterization and Ligand/Inhibitor Identification Provide Functional Insights into the Mycobacterium tuberculosis Cytochrome P450 CYP126A1. The Journal of Biological Chemistry. PMID 27932461 DOI: 10.1074/Jbc.M116.748822 |
0.574 |
|
| 2016 |
Marchetti C, Chan DS, Coyne AG, Abell C. Fragment-based approaches to TB drugs. Parasitology. 1-12. PMID 27804891 DOI: 10.1017/S0031182016001876 |
0.558 |
|
| 2016 |
Butler RN, Coyne AG. Organic synthesis reactions on-water at the organic-liquid water interface. Organic & Biomolecular Chemistry. PMID 27714194 DOI: 10.1039/C6Ob01724J |
0.523 |
|
| 2016 |
Kavanagh ME, Gray JL, Gilbert SH, Coyne AG, McLean KJ, Davis HJ, Munro AW, Abell C. Substrate Fragmentation for the Design of M. tuberculosis CYP121 Inhibitors. Chemmedchem. PMID 27432475 DOI: 10.1002/Cmdc.201600248 |
0.566 |
|
| 2016 |
Davis HJ, Kavanagh ME, Balan T, Abell C, Coyne AG. Spirooxindoles as novel 3D-fragment scaffolds: Synthesis and screening against CYP121 from M. tuberculosis. Bioorganic & Medicinal Chemistry Letters. PMID 27287372 DOI: 10.1016/J.Bmcl.2016.05.073 |
0.567 |
|
| 2016 |
Kavanagh ME, Coyne AG, McLean KJ, James GG, Levy CW, Marino LB, de Carvalho LP, Chan DS, Hudson SA, Surade S, Leys D, Munro AW, Abell C. Fragment-Based Approaches to the Development of Mycobacterium tuberculosis CYP121 Inhibitors. Journal of Medicinal Chemistry. 59: 3272-302. PMID 27002486 DOI: 10.1021/Acs.Jmedchem.6B00007 |
0.598 |
|
| 2016 |
Chenge JT, Le DV, Swami S, McLean KJ, Kavanagh ME, Coyne A, Rigby SJE, Cheesman MYR, Girvan HM, Levy CW, Rupp B, Kries JPv, Abell C, Leys D, Munro A. Crystal structure of Mycobacterium tuberculosis CYP126A1 in complex with 1-(3-(1H-imidazol-1-yl)propyl)-3-((3s,5s,7s)-adamantan-1-yl)urea Journal of Biological Chemistry. DOI: 10.2210/Pdb5Li7/Pdb |
0.465 |
|
| 2016 |
Chan DS, Matak-Vinković D, Coyne AG, Abell C. Insight into Protein Conformation and Subcharging by DMSO from Native Ion Mobility Mass Spectrometry Chemistryselect. 1: 5686-5690. DOI: 10.1002/slct.201601402 |
0.401 |
|
| 2015 |
Butler RN, Coyne AG. Understanding "on-water" catalysis of organic reactions. Effects of H+ and Li+ ions in the aqueous phase and nonreacting competitor H-bond acceptors in the organic phase: on H2O versus on D2O for Huisgen cycloadditions. The Journal of Organic Chemistry. 80: 1809-17. PMID 25621921 DOI: 10.1021/Jo502732Y |
0.519 |
|
| 2015 |
Scott DE, Coyne AG, Venkitaraman A, Blundell TL, Abell C, Hyvönen M. Small-molecule inhibitors that target protein-protein interactions in the RAD51 family of recombinases. Chemmedchem. 10: 296-303. PMID 25470112 DOI: 10.1002/Cmdc.201402428 |
0.568 |
|
| 2014 |
Srinivasan R, Coyne AG, Abell C. Regioselective conversion of arenes to N-aryl-1,2,3-triazoles using C-H borylation. Chemistry (Weinheim An Der Bergstrasse, Germany). 20: 11680-4. PMID 25048717 DOI: 10.1002/Chem.201403021 |
0.718 |
|
| 2013 |
Hudson SA, Surade S, Coyne AG, McLean KJ, Leys D, Munro AW, Abell C. Overcoming the limitations of fragment merging: rescuing a strained merged fragment series targeting Mycobacterium tuberculosis CYP121. Chemmedchem. 8: 1451-6. PMID 23788280 DOI: 10.1002/Cmdc.201300219 |
0.505 |
|
| 2013 |
Butler RN, Coyne AG, Cunningham WJ, Moloney EM. Water and organic synthesis: a focus on the in-water and on-water border. Reversal of the in-water Breslow hydrophobic enhancement of the normal endo-effect on crossing to on-water conditions for Huisgen cycloadditions with increasingly insoluble organic liquid and solid 2π-dipolarophiles. The Journal of Organic Chemistry. 78: 3276-91. PMID 23463988 DOI: 10.1021/Jo400055G |
0.505 |
|
| 2012 |
Scott DE, Coyne AG, Hudson SA, Abell C. Fragment-based approaches in drug discovery and chemical biology. Biochemistry. 51: 4990-5003. PMID 22697260 DOI: 10.1021/Bi3005126 |
0.57 |
|
| 2011 |
Thompson S, Coyne AG, Knipe PC, Smith MD. Asymmetric electrocyclic reactions. Chemical Society Reviews. 40: 4217-31. PMID 21566810 DOI: 10.1039/C1Cs15022G |
0.729 |
|
| 2011 |
Butler RN, Coyne AG. ChemInform Abstract: Water: Nature′s Reaction Enforcer-Comparative Effects for Organic Synthesis “In-Water” and “On-Water” Cheminform. 42: no-no. DOI: 10.1002/CHIN.201130242 |
0.463 |
|
| 2010 |
Kolstoe SE, Mangione PP, Bellotti V, Taylor GW, Tennent GA, Deroo S, Morrison AJ, Cobb AJ, Coyne A, McCammon MG, Warner TD, Mitchell J, Gill R, Smith MD, Ley SV, et al. Trapping of palindromic ligands within native transthyretin prevents amyloid formation. Proceedings of the National Academy of Sciences of the United States of America. 107: 20483-8. PMID 21059958 DOI: 10.1073/Pnas.1008255107 |
0.575 |
|
| 2010 |
Butler RN, Coyne AG. Water: nature's reaction enforcer--comparative effects for organic synthesis "in-water" and "on-water". Chemical Reviews. 110: 6302-37. PMID 20815348 DOI: 10.1021/Cr100162C |
0.503 |
|
| 2010 |
Coyne AG, Scott DE, Abell C. Drugging challenging targets using fragment-based approaches. Current Opinion in Chemical Biology. 14: 299-307. PMID 20223699 DOI: 10.1016/J.Cbpa.2010.02.010 |
0.555 |
|
| 2007 |
Butler RN, Coyne AG, McArdle P, Sibley LM, Burke LA. Uncharacteristic thione behavior in a Huisgen cycloaddition reaction: a kinetic and theoretical study Tetrahedron Letters. 48: 6684-6687. DOI: 10.1016/J.Tetlet.2007.07.138 |
0.522 |
|
| 2007 |
Butler RN, Coyne AG, Moloney EM. Organic synthesis in water: 1,3-dipolar cycloaddition reactions at ambient temperature with aqueous suspensions of solid reactants Tetrahedron Letters. 48: 3501-3503. DOI: 10.1016/J.Tetlet.2007.03.119 |
0.497 |
|
| 2007 |
Coyne AG, Müller-Bunz H, Guiry PJ. The asymmetric synthesis of β-lactams: HETPHOX/Cu(I) mediated synthesis via the Kinugasa reaction Tetrahedron: Asymmetry. 18: 199-207. DOI: 10.1016/J.Tetasy.2007.01.006 |
0.301 |
|
| 2005 |
Butler RN, Coyne AG, Cunningham WJ, Moloney EM, Burke LA. Water and the Huisgen cycloaddition reaction: A focus on polar contributions to the transition state in the reactions of dicyano(phthalazinium) methanide with substituted styrenes and benzylidene acetones Helvetica Chimica Acta. 88: 1611-1629. DOI: 10.1002/Hlca.200590128 |
0.516 |
|
| 2004 |
Butler RN, Cunningham WJ, Coyne AG, Burke LA. The influence of water on the rates of 1,3-dipolar cycloaddition reactions: trigger points for exponential rate increases in water-organic solvent mixtures. Water-super versus water-normal dipolarophiles. Journal of the American Chemical Society. 126: 11923-9. PMID 15382927 DOI: 10.1021/Ja040119Y |
0.447 |
|
| 2002 |
Butler RN, Coyne AG, Cunningham WJ, Burke LA. Kinetic and synthetic influences of water and solvent-free conditions on 1,3-dipolar cycloaddition reactions: the phthalazinium and pyridazinium dicyanomethanide 1,3-dipoles: surprisingly successful synthetic methods Journal of the Chemical Society-Perkin Transactions 1. 1807-1815. DOI: 10.1039/B206028K |
0.518 |
|
| 2001 |
Butler RN, Coyne AG, Burke LA. The kinetic profile of phthalazinium-2-dicyanomethanide 1,3-dipole with 2π-dipolarophiles: U-shaped dipolarophilic activity and classic type II dipole behaviour. Reaction rates and DFT calculations Journal of the Chemical Society-Perkin Transactions 1. 1781-1784. DOI: 10.1039/B103820F |
0.513 |
|
| 2001 |
Butler RN, Coyne AG, McArdle P, Cunningham D, Burke LA. Regioselectivity and endo/exo selectivity in the cycloadditions of the phthalazinium dicyanomethanide 1,3-dipole with unsymmetrical alkene and alkyne dipolarophiles. Unexpected reversals of regiochemistry: a combined experimental and DFT theoretical study Journal of the Chemical Society-Perkin Transactions 1. 1391-1397. DOI: 10.1039/B101150M |
0.519 |
|
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