Richard J. Lewis, PhD - Publications

Affiliations:

University of Queensland

University of Queensland, Saint Lucia, Queensland, Australia

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Year	Citation	Score
2022	Wilhelm P, Luna-Ramirez K, Chin YK, Dekan Z, Abraham N, Tae HS, Chow CY, Eagles DA, King GF, Lewis RJ, Adams DJ, Alewood PF. Cysteine-Rich α-Conotoxin SII Displays Novel Interactions at the Muscle Nicotinic Acetylcholine Receptor. Acs Chemical Neuroscience. PMID 35357806 DOI: 10.1021/acschemneuro.1c00857	0.339
2020	Herzig V, Sunagar K, Wilson DTR, Pineda SS, Israel MR, Dutertre S, McFarland BS, Undheim EAB, Hodgson WC, Alewood PF, Lewis RJ, Bosmans F, Vetter I, King GF, Fry BG. Australian funnel-web spiders evolved human-lethal δ-hexatoxins for defense against vertebrate predators. Proceedings of the National Academy of Sciences of the United States of America. PMID 32958636 DOI: 10.1073/Pnas.2004516117	0.303
2020	Cardoso FC, Marliac MA, Geoffroy C, Schmit M, Bispat A, Lewis RJ, Tuck KL, Duggan PJ. The neuronal calcium ion channel activity of constrained analogues of MONIRO-1. Bioorganic & Medicinal Chemistry. 28: 115655. PMID 32828422 DOI: 10.1016/J.Bmc.2020.115655	0.313
2020	Cardoso FC, Castro J, Grundy L, Schober G, Garcia-Caraballo S, Zhao T, Herzig V, King GF, Brierley SM, Lewis RJ. A spider-venom peptide with multi-target activity on sodium and calcium channels alleviates chronic visceral pain in a model of irritable bowel syndrome. Pain. PMID 32826759 DOI: 10.1097/J.Pain.0000000000002041	0.334
2020	L'Herondelle K, Pierre O, Fouyet S, Leschiera R, Le Gall-Ianotto C, Philippe R, Buscaglia P, Mignen O, Talagas M, Lewis RJ, Michel L, Misery L, Le Garrec R. PAR2, keratinocytes and cathepsin S mediate the sensory effects of ciguatoxins responsible for ciguatera poisoning. The Journal of Investigative Dermatology. PMID 32800876 DOI: 10.1016/J.Jid.2020.07.020	0.31
2020	Wang D, Himaya SWA, Giacomotto J, Hasan MM, Cardoso FC, Ragnarsson L, Lewis RJ. Characterisation of d-Conotoxin TxVIA as a Mammalian T-Type Calcium Channel Modulator. Marine Drugs. 18. PMID 32629781 DOI: 10.3390/Md18070343	0.308
2020	Rupasinghe DB, Herzig V, Vetter I, Dekan Z, Gilchrist J, Bosmans F, Alewood PF, Lewis RJ, King GF. Mutational analysis of ProTx-I and the novel venom peptide Pe1b provide insight into residues responsible for selective inhibition of the analgesic drug target Na1.7. Biochemical Pharmacology. 114080. PMID 32511987 DOI: 10.1016/J.Bcp.2020.114080	0.337
2020	Muttenthaler M, Nevin ST, Inserra M, Lewis RJ, Adams DJ, Alewood P. On-resin strategy to label α-conotoxins: Cy5-RgIA, a potent α9α10 nicotinic acetylcholine receptor imaging probe. Australian Journal of Chemistry. 73: 327-333. PMID 32394983 DOI: 10.1071/Ch19456	0.449
2020	Mohan MK, Abraham N, R P R, Jayaseelan BF, Ragnarsson L, Lewis RJ, Sarma SP. Structure and allosteric activity of a single disulfide conopeptide from at human α3β4 and α7 nicotinic acetylcholine receptors. The Journal of Biological Chemistry. PMID 32234761 DOI: 10.1074/Jbc.Ra119.012098	0.362
2020	Giribaldi J, Ragnarsson L, Pujante T, Enjalbal C, Wilson D, Daly NL, Lewis RJ, Dutertre S. Synthesis, Pharmacological and Structural Characterization of Novel Conopressins from . Marine Drugs. 18. PMID 32155768 DOI: 10.3390/Md18030150	0.342
2019	Dutt M, Giacomotto J, Ragnarsson L, Andersson Å, Brust A, Dekan Z, Alewood PF, Lewis RJ. The α-adrenoceptor inhibitor ρ-TIA facilitates net hunting in piscivorous Conus tulipa. Scientific Reports. 9: 17841. PMID 31780714 DOI: 10.1038/S41598-019-54186-Y	0.335
2019	Dongol Y, Caldas Cardoso F, Lewis RJ. Spider Knottin Pharmacology at Voltage-Gated Sodium Channels and Their Potential to Modulate Pain Pathways. Toxins. 11. PMID 31671792 DOI: 10.3390/Toxins11110626	0.325
2019	Jin AH, Muttenthaler M, Dutertre S, Himaya SWA, Kaas Q, Craik DJ, Lewis RJ, Alewood PF. Conotoxins: Chemistry and Biology. Chemical Reviews. PMID 31633928 DOI: 10.1021/Acs.Chemrev.9B00207	0.357
2019	Cardoso FC, Lewis RJ. Structure-Function and Therapeutic Potential of Spider Venom-Derived Cysteine Knot Peptides Targeting Sodium Channels. Frontiers in Pharmacology. 10: 366. PMID 31031623 DOI: 10.3389/Fphar.2019.00366	0.368
2019	Jin AH, Cristofori-Armstrong B, Rash LD, Román González SA, Espinosa RA, Lewis RJ, Alewood PF, Vetter I. Novel conorfamides from Conus austini venom modulate both nicotinic acetylcholine receptors and acid-sensing ion channels. Biochemical Pharmacology. PMID 31028742 DOI: 10.1016/J.Bcp.2019.04.025	0.363
2019	Ziegman R, Brust A, Jha P, Cardoso FC, Lewis RJ, Alewood PF. 'Messy' Processing of χ-conotoxin MrIA Generates Homologues with Reduced hNET Potency. Marine Drugs. 17. PMID 30875751 DOI: 10.3390/Md17030165	0.351
2019	Ferraz CR, Arrahman A, Xie C, Casewell NR, Lewis RJ, Kool J, Cardoso FC. Multifunctional Toxins in Snake Venoms and Therapeutic Implications: From Pain to Hemorrhage and Necrosis Frontiers in Ecology and Evolution. 7. DOI: 10.3389/Fevo.2019.00218	0.326
2018	Sousa SR, McArthur JR, Brust A, Bhola RF, Rosengren KJ, Ragnarsson L, Dutertre S, Alewood PF, Christie MJ, Adams DJ, Vetter I, Lewis RJ. Novel analgesic ω-conotoxins from the vermivorous cone snail Conus moncuri provide new insights into the evolution of conopeptides. Scientific Reports. 8: 13397. PMID 30194442 DOI: 10.1038/S41598-018-31245-4	0.463
2018	Abraham N, Lewis RJ. Neuronal Nicotinic Acetylcholine Receptor Modulators from Cone Snails. Marine Drugs. 16. PMID 29899286 DOI: 10.3390/Md16060208	0.333
2018	Slagboom J, Otvos RA, Cardoso FC, Iyer J, Visser JC, van Doodewaerd BR, McCleary RJR, Niessen WMA, Somsen GW, Lewis RJ, Kini RM, Smit AB, Casewell NR, Kool J. Neurotoxicity fingerprinting of venoms using on-line microfluidic AChBP profiling. Toxicon : Official Journal of the International Society On Toxinology. PMID 29730150 DOI: 10.1016/J.Toxicon.2018.04.022	0.34
2018	Sairaman A, Cardoso FC, Bispat A, Lewis RJ, Duggan PJ, Tuck KL. Synthesis and evaluation of aminobenzothiazoles as blockers of N- and T-type calcium channels. Bioorganic & Medicinal Chemistry. PMID 29622412 DOI: 10.1016/J.Bmc.2018.03.031	0.302
2018	Himaya SWA, Lewis RJ. Venomics-Accelerated Cone Snail Venom Peptide Discovery. International Journal of Molecular Sciences. 19. PMID 29522462 DOI: 10.3390/Ijms19030788	0.314
2018	Himaya SWA, Marí F, Lewis RJ. Accelerated proteomic visualization of individual predatory venoms of Conus purpurascens reveals separately evolved predation-evoked venom cabals. Scientific Reports. 8: 330. PMID 29321522 DOI: 10.1038/S41598-017-17422-X	0.302
2018	Stefanucci A, Novellino E, Macedonio G, Dimmito MP, Mirzaie S, Cardoso FC, Lewis R, Zádor F, Erdei AI, Dvorácskó S, Tömböly C, Benyhe S, Pieretti S, Minosi P, Mollica A. Design, synthesis and biological profile of mixed opioid agonist/N-VGCC blocker peptides New Journal of Chemistry. 42: 5656-5659. DOI: 10.1039/C7Nj04969B	0.304
2017	Adams DJ, Lewis RJ. Neuropharmacology of venom peptides. Neuropharmacology. PMID 29154773 DOI: 10.1016/J.Neuropharm.2017.11.025	0.409
2017	Prashanth JR, Dutertre S, Lewis RJ. Pharmacology of predatory and defensive venom peptides in cone snails. Molecular Biosystems. PMID 29090697 DOI: 10.1039/C7Mb00511C	0.317
2017	Jin AH, Dekan Z, Smout MJ, Wilson D, Dutertre S, Vetter I, Lewis RJ, Loukas A, Daly NL, Alewood PF. Conotoxin Φ-MiXXVIIA from the new superfamily G2 employs a novel cysteine framework that mimics granulin and displays anti-apoptotic activity. Angewandte Chemie (International Ed. in English). PMID 28984021 DOI: 10.1002/Anie.201708927	0.366
2017	Sousa SR, Wingerd JS, Brust A, Bladen C, Ragnarsson L, Herzig V, Deuis JR, Dutertre S, Vetter I, Zamponi GW, King GF, Alewood PF, Lewis RJ. Discovery and mode of action of a novel analgesic β-toxin from the African spider Ceratogyrus darlingi. Plos One. 12: e0182848. PMID 28880874 DOI: 10.1371/Journal.Pone.0182848	0.352
2017	Touska F, Sattler S, Malsch P, Lewis RJ, Reeh PW, Zimmermann K. Ciguatoxins Evoke Potent CGRP Release by Activation of Voltage-Gated Sodium Channel Subtypes NaV1.9, NaV1.7 and NaV1.1. Marine Drugs. 15. PMID 28867800 DOI: 10.3390/Md15090269	0.331
2017	Cardoso FC, Lewis RJ. Sodium channels and pain: from toxins to therapies. British Journal of Pharmacology. PMID 28749537 DOI: 10.1111/Bph.13962	0.314
2017	McArthur JR, Motin L, Gleeson EC, Spiller S, Lewis RJ, Duggan PJ, Tuck KL, Adams DJ. Inhibition of human N- and T-type calcium channels by an ortho-phenoxyanilide derivative, MONIRO-1. British Journal of Pharmacology. PMID 28608537 DOI: 10.1111/Bph.13910	0.424
2017	Cardoso FC, Dekan Z, Smith JJ, Deuis JR, Vetter I, Herzig V, Alewood PF, King GF, Lewis RJ. Modulatory features of the novel spider toxin μ-TRTX-Df1a isolated from the venom of the spider Davus fasciatus. British Journal of Pharmacology. PMID 28542706 DOI: 10.1111/Bph.13865	0.305
2017	Wingerd JS, Mozar CA, Ussing CA, Murali SS, Chin YK, Cristofori-Armstrong B, Durek T, Gilchrist J, Vaughan CW, Bosmans F, Adams DJ, Lewis RJ, Alewood PF, Mobli M, Christie MJ, et al. The tarantula toxin β/δ-TRTX-Pre1a highlights the importance of the S1-S2 voltage-sensor region for sodium channel subtype selectivity. Scientific Reports. 7: 974. PMID 28428547 DOI: 10.1038/S41598-017-01129-0	0.454
2017	Windley MJ, Vetter I, Lewis RJ, Nicholson GM. Lethal effects of an insecticidal spider venom peptide involve positive allosteric modulation of insect nicotinic acetylcholine receptors. Neuropharmacology. PMID 28396143 DOI: 10.1016/J.Neuropharm.2017.04.008	0.36
2017	Abraham N, Healy M, Ragnarsson L, Brust A, Alewood PF, Lewis RJ. Structural mechanisms for α-conotoxin activity at the human α3β4 nicotinic acetylcholine receptor. Scientific Reports. 7: 45466. PMID 28361878 DOI: 10.1038/Srep45466	0.312
2017	Rahnama S, Deuis JR, Cardoso FC, Ramanujam V, Lewis RJ, Rash LD, King GF, Vetter I, Mobli M. The structure, dynamics and selectivity profile of a NaV1.7 potency-optimised huwentoxin-IV variant. Plos One. 12: e0173551. PMID 28301520 DOI: 10.1371/Journal.Pone.0173551	0.356
2017	Inserra MC, Israel MR, Caldwell A, Castro J, Deuis JR, Harrington AM, Keramidas A, Garcia-Caraballo S, Maddern J, Erickson A, Grundy L, Rychkov GY, Zimmermann K, Lewis RJ, Brierley SM, et al. Multiple sodium channel isoforms mediate the pathological effects of Pacific ciguatoxin-1. Scientific Reports. 7: 42810. PMID 28225079 DOI: 10.1038/Srep42810	0.332
2017	Deuis JR, Dekan Z, Wingerd JS, Smith JJ, Munasinghe NR, Bhola RF, Imlach WL, Herzig V, Armstrong DA, Rosengren KJ, Bosmans F, Waxman SG, Dib-Hajj SD, Escoubas P, Minett MS, ... ... Lewis RJ, et al. Pharmacological characterisation of the highly NaV1.7 selective spider venom peptide Pn3a. Scientific Reports. 7: 40883. PMID 28106092 DOI: 10.1038/Srep40883	0.333
2017	Wan J, Mobli M, Brust A, Muttenthaler M, Andersson Å, Ragnarsson L, Castro J, Vetter I, Huang JX, Nilsson M, Brierley SM, Cooper MA, Lewis RJ, Alewood PF. Synthesis of Multivalent [Lys8]-Oxytocin Dendrimers that Inhibit Visceral Nociceptive Responses Australian Journal of Chemistry. 70: 162. DOI: 10.1071/Ch16407	0.348
2016	Over B, Matsson P, Tyrchan C, Artursson P, Doak BC, Foley MA, Hilgendorf C, Johnston SE, Lee MD, Lewis RJ, McCarren P, Muncipinto G, Norinder U, Perry MW, Duvall JR, et al. Structural and conformational determinants of macrocycle cell permeability. Nature Chemical Biology. PMID 27748751 DOI: 10.1038/Nchembio.2203	0.31
2016	Bressan E, Touska F, Vetter I, Kistner K, Kichko TI, Teixeira NB, Picolo G, Cury Y, Lewis RJ, Fischer MJ, Zimmermann K, Reeh PW. Crotalphine desensitizes TRPA1 ion channels to alleviate inflammatory hyperalgesia. Pain. PMID 27434506 DOI: 10.1097/J.Pain.0000000000000669	0.348
2016	Deuis JR, Dekan Z, Inserra MC, Lee TH, Aguilar MI, Craik DJ, Lewis RJ, Alewood PF, Mobli M, Schroeder CI, Henriques ST, Vetter I. Development of a μO-conotoxin Analogue with Improved Lipid Membrane Interactions and Potency for the Analgesic Target NaV1.8. The Journal of Biological Chemistry. PMID 27026701 DOI: 10.1074/Jbc.M116.721662	0.324
2016	Wan J, Brust A, Bhola RF, Jha P, Mobli M, Lewis RJ, Christie MJ, Alewood PF. Inhibition of the norepinephrine transporter by χ-conotoxin dendrimers. Journal of Peptide Science : An Official Publication of the European Peptide Society. PMID 26910400 DOI: 10.1002/Psc.2857	0.325
2015	Prashanth JR, Dutertre S, Jin AH, Lavergne V, Hamilton B, Cardoso FC, Griffin J, Venter DJ, Alewood PF, Lewis RJ. The role of defensive ecological interactions in the evolution of conotoxins. Molecular Ecology. PMID 26614983 DOI: 10.1111/Mec.13504	0.315
2015	Jin AH, Vetter I, Himaya SW, Alewood PF, Lewis RJ, Dutertre S. Transcriptome and proteome of Conus planorbis identify the nicotinic receptors as primary target for the defensive venom. Proteomics. PMID 26506909 DOI: 10.1002/Pmic.201500220	0.313
2015	Himaya SW, Jin AH, Dutertre S, Giacomotto J, Mohialdeen H, Vetter I, Alewood PF, Lewis RJ. Comparative Venomics Reveals the Complex Prey Capture Strategy of the Piscivorous Cone Snail Conus catus. Journal of Proteome Research. 14: 4372-81. PMID 26322961 DOI: 10.1021/Acs.Jproteome.5B00630	0.358
2015	Deuis JR, Whately E, Brust A, Inserra MC, Asvadi NH, Lewis RJ, Alewood PF, Cabot PJ, Vetter I. Activation of κ Opioid Receptors in Cutaneous Nerve Endings by Conorphin-1, a Novel Subtype-Selective Conopeptide, Does Not Mediate Peripheral Analgesia. Acs Chemical Neuroscience. 6: 1751-8. PMID 26225903 DOI: 10.1021/Acschemneuro.5B00113	0.301
2015	Jin AH, Israel MR, Inserra MC, Smith JJ, Lewis RJ, Alewood PF, Vetter I, Dutertre S. δ-Conotoxin SuVIA suggests an evolutionary link between ancestral predator defence and the origin of fish-hunting behaviour in carnivorous cone snails. Proceedings. Biological Sciences / the Royal Society. 282. PMID 26156767 DOI: 10.1098/Rspb.2015.0817	0.349
2015	Cardoso FC, Dekan Z, Rosengren KJ, Erickson A, Vetter I, Deuis JR, Herzig V, Alewood PF, King GF, Lewis RJ. Identification and Characterization of ProTx-III [μ-TRTX-Tp1a], a New Voltage-Gated Sodium Channel Inhibitor from Venom of the Tarantula Thrixopelma pruriens. Molecular Pharmacology. 88: 291-303. PMID 25979003 DOI: 10.1124/Mol.115.098178	0.38
2015	Gleeson EC, Graham JE, Spiller S, Vetter I, Lewis RJ, Duggan PJ, Tuck KL. Inhibition of N-type calcium channels by fluorophenoxyanilide derivatives. Marine Drugs. 13: 2030-45. PMID 25871286 DOI: 10.3390/Md13042030	0.31
2015	Klint JK, Smith JJ, Vetter I, Rupasinghe DB, Er SY, Senff S, Herzig V, Mobli M, Lewis RJ, Bosmans F, King GF. Seven novel modulators of the analgesic target NaV 1.7 uncovered using a high-throughput venom-based discovery approach. British Journal of Pharmacology. 172: 2445-58. PMID 25754331 DOI: 10.1111/Bph.13081	0.307
2015	Wan J, Huang JX, Vetter I, Mobli M, Lawson J, Tae HS, Abraham N, Paul B, Cooper MA, Adams DJ, Lewis RJ, Alewood PF. α-Conotoxin dendrimers have enhanced potency and selectivity for homomeric nicotinic acetylcholine receptors. Journal of the American Chemical Society. 137: 3209-12. PMID 25710197 DOI: 10.1021/Jacs.5B00244	0.428
2015	Mueller A, Starobova H, Inserra MC, Jin AH, Deuis JR, Dutertre S, Lewis RJ, Alewood PF, Daly NL, Vetter I. Î±-Conotoxin MrIC is a biased agonist at Î±7 nicotinic acetylcholine receptors. Biochemical Pharmacology. 94: 155-63. PMID 25646788 DOI: 10.1016/J.Bcp.2015.01.011	0.313
2015	Ragnarsson L, Andersson Ã…, Thomas WG, Lewis RJ. Extracellular surface residues of the Î±1B-adrenoceptor critical for G protein-coupled receptor function. Molecular Pharmacology. 87: 121-9. PMID 25352041 DOI: 10.1124/Mol.114.094557	0.306
2014	Hopping G, Wang CI, Hogg RC, Nevin ST, Lewis RJ, Adams DJ, Alewood PF. Hydrophobic residues at position 10 of Î±-conotoxin PnIA influence subtype selectivity between Î±7 and Î±3Î²2 neuronal nicotinic acetylcholine receptors. Biochemical Pharmacology. 91: 534-42. PMID 25101833 DOI: 10.1016/J.Bcp.2014.07.025	0.448
2014	Hoyland CN, Aldridge C, Cleverley RM, Duchêne MC, Minasov G, Onopriyenko O, Sidiq K, Stogios PJ, Anderson WF, Daniel RA, Savchenko A, Vollmer W, Lewis RJ. Structure of the LdcB LD-carboxypeptidase reveals the molecular basis of peptidoglycan recognition. Structure (London, England : 1993). 22: 949-60. PMID 24909784 DOI: 10.1016/J.Str.2014.04.015	0.321
2014	Wang CI, Reeks T, Vetter I, Vergara I, Kovtun O, Lewis RJ, Alewood PF, Durek T. Isolation and structural and pharmacological characterization of Î±-elapitoxin-Dpp2d, an amidated three finger toxin from black mamba venom. Biochemistry. 53: 3758-66. PMID 24867092 DOI: 10.1021/Bi5004475	0.344
2014	Heus F, Otvos RA, Aspers RL, van Elk R, Halff JI, Ehlers AW, Dutertre S, Lewis RJ, Wijmenga S, Smit AB, Niessen WM, Kool J. Miniaturized bioaffinity assessment coupled to mass spectrometry for guided purification of bioactives from toad and cone snail. Biology. 3: 139-56. PMID 24833338 DOI: 10.3390/Biology3010139	0.313
2014	Akondi KB, Muttenthaler M, Dutertre S, Kaas Q, Craik DJ, Lewis RJ, Alewood PF. Discovery, synthesis, and structure-activity relationships of conotoxins. Chemical Reviews. 114: 5815-47. PMID 24720541 DOI: 10.1021/Cr400401E	0.306
2014	de Araujo AD, Mobli M, Castro J, Harrington AM, Vetter I, Dekan Z, Muttenthaler M, Wan J, Lewis RJ, King GF, Brierley SM, Alewood PF. Selenoether oxytocin analogues have analgesic properties in a mouse model of chronic abdominal pain. Nature Communications. 5: 3165. PMID 24476666 DOI: 10.1038/Ncomms4165	0.334
2014	Jin AH, Vetter I, Dutertre S, Abraham N, Emidio NB, Inserra M, Murali SS, Christie MJ, Alewood PF, Lewis RJ. MrIC, a novel Î±-conotoxin agonist in the presence of PNU at endogenous Î±7 nicotinic acetylcholine receptors. Biochemistry. 53: 1-3. PMID 24351107 DOI: 10.1021/Bi400882S	0.318
2014	Akondi KB, Lewis RJ, Alewood PF. Re-engineering the μ-conotoxin SIIIA scaffold. Biopolymers. 101: 347-54. PMID 23913763 DOI: 10.1002/Bip.22368	0.341
2013	Sadeghi M, Murali SS, Lewis RJ, Alewood PF, Mohammadi S, Christie MJ. Novel Ï‰-conotoxins from C. catus reverse signs of mouse inflammatory pain after systemic administration. Molecular Pain. 9: 51. PMID 24139484 DOI: 10.1186/1744-8069-9-51	0.305
2013	Vetter I, Hein A, Sattler S, Hessler S, Touska F, Bressan E, Parra A, Hager U, Leffler A, Boukalova S, Nissen M, Lewis RJ, Belmonte C, Alzheimer C, Huth T, et al. Amplified cold transduction in native nociceptors by M-channel inhibition. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 33: 16627-41. PMID 24133266 DOI: 10.1523/Jneurosci.1473-13.2013	0.318
2013	Brust A, Wang CI, Daly NL, Kennerly J, Sadeghi M, Christie MJ, Lewis RJ, Mobli M, Alewood PF. Vicinal disulfide constrained cyclic peptidomimetics: a turn mimetic scaffold targeting the norepinephrine transporter. Angewandte Chemie (International Ed. in English). 52: 12020-3. PMID 24115503 DOI: 10.1002/Anie.201304660	0.3
2013	Jin AH, Dutertre S, Kaas Q, Lavergne V, Kubala P, Lewis RJ, Alewood PF. Transcriptomic messiness in the venom duct of Conus miles contributes to conotoxin diversity. Molecular & Cellular Proteomics : McP. 12: 3824-33. PMID 24043424 DOI: 10.1074/Mcp.M113.030353	0.329
2013	Inserra MC, Kompella SN, Vetter I, Brust A, Daly NL, Cuny H, Craik DJ, Alewood PF, Adams DJ, Lewis RJ. Isolation and characterization of Î±-conotoxin LsIA with potent activity at nicotinic acetylcholine receptors. Biochemical Pharmacology. 86: 791-9. PMID 23924607 DOI: 10.1016/J.Bcp.2013.07.016	0.464
2013	Zimmermann K, Deuis JR, Inserra MC, Collins LS, Namer B, Cabot PJ, Reeh PW, Lewis RJ, Vetter I. Analgesic treatment of ciguatoxin-induced cold allodynia. Pain. 154: 1999-2006. PMID 23778293 DOI: 10.1016/J.Pain.2013.06.015	0.322
2013	Jayamanne A, Jeong HJ, Schroeder CI, Lewis RJ, Christie MJ, Vaughan CW. Spinal actions of Ï‰-conotoxins, CVID, MVIIA and related peptides in a rat neuropathic pain model. British Journal of Pharmacology. 170: 245-54. PMID 23713957 DOI: 10.1111/Bph.12251	0.306
2013	Deuis JR, Zimmermann K, Romanovsky AA, Possani LD, Cabot PJ, Lewis RJ, Vetter I. An animal model of oxaliplatin-induced cold allodynia reveals a crucial role for Nav1.6 in peripheral pain pathways. Pain. 154: 1749-57. PMID 23711479 DOI: 10.1016/J.Pain.2013.05.032	0.314
2013	Smith JJ, Vetter I, Lewis RJ, Peigneur S, Tytgat J, Lam A, Gallant EM, Beard NA, Alewood PF, Dulhunty AF. Multiple actions of phi-LITX-Lw1a on ryanodine receptors reveal a functional link between scorpion DDH and ICK toxins. Proceedings of the National Academy of Sciences of the United States of America. 110: 8906-11. PMID 23671114 DOI: 10.1073/Pnas.1214062110	0.357
2013	Sousa SR, Vetter I, Ragnarsson L, Lewis RJ. Expression and pharmacology of endogenous Cav channels in SH-SY5Y human neuroblastoma cells. Plos One. 8: e59293. PMID 23536870 DOI: 10.1371/Journal.Pone.0059293	0.344
2013	Durek T, Vetter I, Wang CI, Motin L, Knapp O, Adams DJ, Lewis RJ, Alewood PF. Chemical engineering and structural and pharmacological characterization of the Î±-scorpion toxin OD1. Acs Chemical Biology. 8: 1215-22. PMID 23527544 DOI: 10.1021/Cb400012K	0.48
2013	Sousa SR, Vetter I, Lewis RJ. Venom peptides as a rich source of cav2.2 channel blockers. Toxins. 5: 286-314. PMID 23381143 DOI: 10.3390/Toxins5020286	0.3
2013	Brust A, Sunagar K, Undheim EA, Vetter I, Yang DC, Yang DC, Casewell NR, Jackson TN, Koludarov I, Alewood PF, Hodgson WC, Lewis RJ, King GF, Antunes A, Hendrikx I, et al. Differential evolution and neofunctionalization of snake venom metalloprotease domains. Molecular & Cellular Proteomics : McP. 12: 651-63. PMID 23242553 DOI: 10.1074/Mcp.M112.023135	0.328
2013	Ragnarsson L, Wang CI, Andersson Ã…, Fajarningsih D, Monks T, Brust A, Rosengren KJ, Lewis RJ. Conopeptide Ï-TIA defines a new allosteric site on the extracellular surface of the Î±1B-adrenoceptor. The Journal of Biological Chemistry. 288: 1814-27. PMID 23184947 DOI: 10.1074/Jbc.M112.430785	0.337
2013	Dutertre S, Jin AH, Kaas Q, Jones A, Alewood PF, Lewis RJ. Deep venomics reveals the mechanism for expanded peptide diversity in cone snail venom. Molecular & Cellular Proteomics : McP. 12: 312-29. PMID 23152539 DOI: 10.1074/Mcp.M112.021469	0.316
2013	Wang CI, Lewis RJ. Emerging opportunities for allosteric modulation of G-protein coupled receptors. Biochemical Pharmacology. 85: 153-62. PMID 22975406 DOI: 10.1016/J.Bcp.2012.09.001	0.31
2012	Schroeder CI, Nielsen KJ, Adams DA, Loughnan M, Thomas L, Alewood PF, Lewis RJ, Craik DJ. Effects of Lys2 to Ala2 substitutions on the structure and potency of Ï‰-conotoxins MVIIA and CVID. Biopolymers. 98: 345-56. PMID 23193599 DOI: 10.1002/Bip.22031	0.343
2012	Vetter I, Touska F, Hess A, Hinsbey R, Sattler S, Lampert A, Sergejeva M, Sharov A, Collins LS, Eberhardt M, Engel M, Cabot PJ, Wood JN, Vlachová V, Reeh PW, ... Lewis RJ, et al. Ciguatoxins activate specific cold pain pathways to elicit burning pain from cooling. The Embo Journal. 31: 3795-808. PMID 22850668 DOI: 10.1038/Emboj.2012.207	0.315
2012	Vetter I, Lewis RJ. Therapeutic potential of cone snail venom peptides (conopeptides). Current Topics in Medicinal Chemistry. 12: 1546-52. PMID 22827523 DOI: 10.2174/156802612802652457	0.334
2012	Marcon F, Leblanc M, Vetter I, Lewis RJ, Escoubas P, Nicholson GM. Pharmacological characterization of Î±-elapitoxin-Al2a from the venom of the Australian pygmy copperhead (Austrelaps labialis): an atypical long-chain Î±-neurotoxin with only weak affinity for Î±7 nicotinic receptors. Biochemical Pharmacology. 84: 851-63. PMID 22771828 DOI: 10.1016/J.Bcp.2012.06.024	0.326
2012	Schroeder CI, Adams D, Thomas L, Alewood PF, Lewis RJ. N- and C-terminal extensions of Î¼-conotoxins increase potency and selectivity for neuronal sodium channels. Biopolymers. 98: 161-5. PMID 22733528 DOI: 10.1002/Bip.22032	0.362
2012	Vetter I, Dekan Z, Knapp O, Adams DJ, Alewood PF, Lewis RJ. Isolation, characterization and total regioselective synthesis of the novel Î¼O-conotoxin MfVIA from Conus magnificus that targets voltage-gated sodium channels. Biochemical Pharmacology. 84: 540-8. PMID 22609441 DOI: 10.1016/J.Bcp.2012.05.008	0.447
2012	Dekan Z, Wang CI, Andrews RK, Lewis RJ, Alewood PF. Conotoxin engineering: dual pharmacophoric noradrenaline transport inhibitor/integrin binding peptide with improved stability. Organic & Biomolecular Chemistry. 10: 5791-4. PMID 22581211 DOI: 10.1039/C2Ob25133G	0.307
2012	Prashanth JR, Lewis RJ, Dutertre S. Towards an integrated venomics approach for accelerated conopeptide discovery. Toxicon : Official Journal of the International Society On Toxinology. 60: 470-7. PMID 22564717 DOI: 10.1016/J.Toxicon.2012.04.340	0.314
2012	Knapp O, Nevin ST, Yasuda T, Lawrence N, Lewis RJ, Adams DJ. Biophysical properties of Na(v) 1.8/Na(v) 1.2 chimeras and inhibition by ÂµO-conotoxin MrVIB. British Journal of Pharmacology. 166: 2148-60. PMID 22452751 DOI: 10.1111/J.1476-5381.2012.01955.X	0.426
2012	Lewis RJ, Dutertre S, Vetter I, Christie MJ. Conus venom peptide pharmacology. Pharmacological Reviews. 64: 259-98. PMID 22407615 DOI: 10.1124/Pr.111.005322	0.367
2012	Lewis RJ. Discovery and development of the χ-conopeptide class of analgesic peptides. Toxicon : Official Journal of the International Society On Toxinology. 59: 524-8. PMID 21839105 DOI: 10.1016/J.Toxicon.2011.07.012	0.321
2011	Dekan Z, Vetter I, Daly NL, Craik DJ, Lewis RJ, Alewood PF. α-Conotoxin ImI incorporating stable cystathionine bridges maintains full potency and identical three-dimensional structure. Journal of the American Chemical Society. 133: 15866-9. PMID 21899353 DOI: 10.1021/Ja206408Q	0.331
2011	Inserra MC, Lewis RJ. Venom Peptide modulators of the immune system. Inflammation & Allergy Drug Targets. 10: 399-410. PMID 21824080 DOI: 10.2174/187152811797200687	0.352
2011	Debieux CM, Dridge EJ, Mueller CM, Splatt P, Paszkiewicz K, Knight I, Florance H, Love J, Titball RW, Lewis RJ, Richardson DJ, Butler CS. A bacterial process for selenium nanosphere assembly. Proceedings of the National Academy of Sciences of the United States of America. 108: 13480-5. PMID 21808043 DOI: 10.1073/Pnas.1105959108	0.301
2011	Montanier CY, Correia MA, Flint JE, Zhu Y, Baslé A, McKee LS, Prates JA, Polizzi SJ, Coutinho PM, Lewis RJ, Henrissat B, Fontes CM, Gilbert HJ. A novel, noncatalytic carbohydrate-binding module displays specificity for galactose-containing polysaccharides through calcium-mediated oligomerization. The Journal of Biological Chemistry. 286: 22499-509. PMID 21454512 DOI: 10.1074/Jbc.M110.217372	0.302
2010	Morales RA, Daly NL, Vetter I, Mobli M, Napier IA, Craik DJ, Lewis RJ, Christie MJ, King GF, Alewood PF, Durek T. Chemical synthesis and structure of the prokineticin Bv8. Chembiochem : a European Journal of Chemical Biology. 11: 1882-8. PMID 20677202 DOI: 10.1002/Cbic.201000330	0.355
2010	Grishin AA, Wang CI, Muttenthaler M, Alewood PF, Lewis RJ, Adams DJ. Alpha-conotoxin AuIB isomers exhibit distinct inhibitory mechanisms and differential sensitivity to stoichiometry of alpha3beta4 nicotinic acetylcholine receptors. The Journal of Biological Chemistry. 285: 22254-63. PMID 20466726 DOI: 10.1074/Jbc.M110.111880	0.444
2010	Dutertre S, Lewis RJ. Use of venom peptides to probe ion channel structure and function Journal of Biological Chemistry. 285: 13315-13320. PMID 20189991 DOI: 10.1074/Jbc.R109.076596	0.347
2010	Muttenthaler M, Nevin ST, Grishin AA, Ngo ST, Choy PT, Daly NL, Hu SH, Armishaw CJ, Wang CI, Lewis RJ, Martin JL, Noakes PG, Craik DJ, Adams DJ, Alewood PF. Solving the alpha-conotoxin folding problem: efficient selenium-directed on-resin generation of more potent and stable nicotinic acetylcholine receptor antagonists. Journal of the American Chemical Society. 132: 3514-22. PMID 20163143 DOI: 10.1021/Ja910602H	0.428
2010	Luo S, Akondi KB, Zhangsun D, Wu Y, Zhu X, Hu Y, Christensen S, Dowell C, Daly NL, Craik DJ, Wang CIA, Lewis RJ, Alewood PF, McIntosh JM. Atypical α-conotoxin LtIA from Conus litteratus targets a novel microsite of the α3β2 nicotinic receptor Journal of Biological Chemistry. 285: 12355-12366. PMID 20145249 DOI: 10.1074/Jbc.M109.079012	0.322
2010	Berecki G, Motin L, Haythornthwaite A, Vink S, Bansal P, Drinkwater R, Wang CI, Moretta M, Lewis RJ, Alewood PF, Christie MJ, Adams DJ. Analgesic (omega)-conotoxins CVIE and CVIF selectively and voltage-dependently block recombinant and native N-type calcium channels. Molecular Pharmacology. 77: 139-48. PMID 19892914 DOI: 10.1124/Mol.109.058834	0.476
2010	Vetter I, Lewis RJ. Characterization of endogenous calcium responses in neuronal cell lines Biochemical Pharmacology. 79: 908-920. PMID 19883631 DOI: 10.1016/J.Bcp.2009.10.020	0.304
2009	Lewis RJ. Conotoxin venom peptide therapeutics Advances in Experimental Medicine and Biology. 655: 44-48. PMID 20047034 DOI: 10.1007/978-1-4419-1132-2_5	0.321
2009	Brust A, Palant E, Croker DE, Colless B, Drinkwater R, Patterson B, Schroeder CI, Wilson D, Nielsen CK, Smith MT, Alewood D, Alewood PF, Lewis RJ. chi-Conopeptide pharmacophore development: toward a novel class of norepinephrine transporter inhibitor (Xen2174) for pain. Journal of Medicinal Chemistry. 52: 6991-7002. PMID 19860431 DOI: 10.1021/Jm9003413	0.319
2009	Chan LY, Wang CK, Major JM, Greenwood KP, Lewis RJ, Craik DJ, Daly NL. Isolation and characterization of peptides from Momordica cochinchinensis seeds. Journal of Natural Products. 72: 1453-8. PMID 19711988 DOI: 10.1021/Np900174N	0.311
2009	Loughnan ML, Nicke A, Lawrence N, Lewis RJ. Novel alpha D-conopeptides and their precursors identified by cDNA cloning define the D-conotoxin superfamily. Biochemistry. 48: 3717-29. PMID 19275168 DOI: 10.1021/Bi9000326	0.314
2009	Lewis RJ. Conotoxins: molecular and therapeutic targets Progress in Molecular and Subcellular Biology. 46: 45-65. PMID 19184584 DOI: 10.1007/978-3-540-87895-7_2	0.324
2009	Zamponi GW, Lewis RJ, Todorovic SM, Arneric SP, Snutch TP. Role of voltage-gated calcium channels in ascending pain pathways. Brain Research Reviews. 60: 84-9. PMID 19162069 DOI: 10.1016/J.Brainresrev.2008.12.021	0.333
2009	Millard EL, Nevin ST, Loughnan ML, Nicke A, Clark RJ, Alewood PF, Lewis RJ, Adams DJ, Craik DJ, Daly NL. Inhibition of neuronal nicotinic acetylcholine receptor subtypes by alpha-Conotoxin GID and analogues. The Journal of Biological Chemistry. 284: 4944-51. PMID 19098004 DOI: 10.1074/Jbc.M804950200	0.459
2009	Hopping G, Lewis RJ, Alewood PF. Rapid access to ω-conotoxin chimeras using native chemical ligation Australian Journal of Chemistry. 62: 1333-1338. DOI: 10.1071/Ch09216	0.328
2008	Mattei C, Wen PJ, Nguyen-Huu TD, Alvarez M, Benoit E, Bourdelais AJ, Lewis RJ, Baden DG, Molgó J, Meunier FA. Brevenal inhibits pacific ciguatoxin-1B-induced neurosecretion from bovine chromaffin cells. Plos One. 3: e3448. PMID 18941627 DOI: 10.1371/Journal.Pone.0003448	0.323
2008	Jin AH, Daly NL, Nevin ST, Wang CI, Dutertre S, Lewis RJ, Adams DJ, Craik DJ, Alewood PF. Molecular engineering of conotoxins: the importance of loop size to alpha-conotoxin structure and function. Journal of Medicinal Chemistry. 51: 5575-84. PMID 18754612 DOI: 10.1021/Jm800278K	0.422
2008	Schroeder CI, Ekberg J, Nielsen KJ, Adams D, Loughnan ML, Thomas L, Adams DJ, Alewood PF, Lewis RJ. Neuronally micro-conotoxins from Conus striatus utilize an alpha-helical motif to target mammalian sodium channels. The Journal of Biological Chemistry. 283: 21621-8. PMID 18522941 DOI: 10.1074/Jbc.M802852200	0.472
2008	Duggan PJ, Faber JM, Graham JE, Lewis RJ, Lumsden NG, Tuck KL. Synthesis and Cav2.2 binding data for non-peptide mimetics of ω-conotoxin GVIA based on a 5-amino-anthranilamide core Australian Journal of Chemistry. 61: 11-15. DOI: 10.1071/Ch07327	0.337
2007	Dutertre S, Ulens C, Büttner R, Fish A, van Elk R, Kendel Y, Hopping G, Alewood PF, Schroeder C, Nicke A, Smit AB, Sixma TK, Lewis RJ. AChBP-targeted alpha-conotoxin correlates distinct binding orientations with nAChR subtype selectivity. The Embo Journal. 26: 3858-67. PMID 17660751 DOI: 10.1038/Sj.Emboj.7601785	0.332
2007	Blanchfield JT, Gallagher OP, Cros C, Lewis RJ, Alewood PF, Toth I. Oral absorption and in vivo biodistribution of alpha-conotoxin MII and a lipidic analogue. Biochemical and Biophysical Research Communications. 361: 97-102. PMID 17640618 DOI: 10.1016/J.Bbrc.2007.06.138	0.314
2007	Drew LJ, Rugiero F, Cesare P, Gale JE, Abrahamsen B, Bowden S, Heinzmann S, Robinson M, Brust A, Colless B, Lewis RJ, Wood JN. High-threshold mechanosensitive ion channels blocked by a novel conopeptide mediate pressure-evoked pain. Plos One. 2: e515. PMID 17565368 DOI: 10.1371/Journal.Pone.0000515	0.342
2007	Motin L, Yasuda T, Schroeder CI, Lewis RJ, Adams DJ. Omega-conotoxin CVIB differentially inhibits native and recombinant N- and P/Q-type calcium channels. The European Journal of Neuroscience. 25: 435-44. PMID 17284184 DOI: 10.1111/J.1460-9568.2006.05299.X	0.443
2007	Lewis RJ, Schroeder CI, Ekberg J, Nielsen KJ, Loughnan M, Thomas L, Adams DA, Drinkwater R, Adams DJ, Alewood PF. Isolation and structure-activity of mu-conotoxin TIIIA, a potent inhibitor of tetrodotoxin-sensitive voltage-gated sodium channels. Molecular Pharmacology. 71: 676-85. PMID 17142296 DOI: 10.1124/Mol.106.028225	0.494
2007	Dekan Z, Paczkowski FA, Lewis RJ, Alewood PF. Synthesis and In vitro Biological Activity of Cyclic Lipophilic χ-Conotoxin MrIA Analogues International Journal of Peptide Research and Therapeutics. 13: 307-312. DOI: 10.1007/S10989-007-9083-2	0.34
2006	Ekberg J, Jayamanne A, Vaughan CW, Aslan S, Thomas L, Mould J, Drinkwater R, Baker MD, Abrahamsen B, Wood JN, Adams DJ, Christie MJ, Lewis RJ. muO-conotoxin MrVIB selectively blocks Nav1.8 sensory neuron specific sodium channels and chronic pain behavior without motor deficits. Proceedings of the National Academy of Sciences of the United States of America. 103: 17030-5. PMID 17077153 DOI: 10.1073/Pnas.0601819103	0.427
2006	Schroeder CI, Doering CJ, Zamponi GW, Lewis RJ. N-type calcium channel blockers: novel therapeutics for the treatment of pain. Medicinal Chemistry (ShäRiqah (United Arab Emirates)). 2: 535-43. PMID 17017994 DOI: 10.2174/157340606778250216	0.302
2006	St Pierre L, Flight S, Masci PP, Hanchard KJ, Lewis RJ, Alewood PF, de Jersey J, Lavin MF. Cloning and characterisation of natriuretic peptides from the venom glands of Australian elapids. Biochimie. 88: 1923-31. PMID 16908092 DOI: 10.1016/J.Biochi.2006.06.014	0.322
2006	Dutertre S, Lumsden NG, Alewood PF, Lewis RJ. Isolation and characterisation of conomap-Vt, a D-amino acid containing excitatory peptide from the venom of a vermivorous cone snail. Febs Letters. 580: 3860-6. PMID 16797543 DOI: 10.1016/J.Febslet.2006.06.011	0.322
2006	Loughnan M, Nicke A, Jones A, Schroeder CI, Nevin ST, Adams DJ, Alewood PF, Lewis RJ. Identification of a novel class of nicotinic receptor antagonists: dimeric conotoxins VxXIIA, VxXIIB, and VxXIIC from Conus vexillum. The Journal of Biological Chemistry. 281: 24745-55. PMID 16790424 DOI: 10.1074/Jbc.M603703200	0.495
2006	Dutertre S, Lewis RJ. Toxin insights into nicotinic acetylcholine receptors Biochemical Pharmacology. 72: 661-670. PMID 16716265 DOI: 10.1016/J.Bcp.2006.03.027	0.34
2006	Ragnarsson L, Yasuda T, Lewis RJ, Dodd PR, Adams DJ. NMDA receptor subunit-dependent modulation by conantokin-G and Ala7-conantokin-G. Journal of Neurochemistry. 96: 283-91. PMID 16336218 DOI: 10.1111/J.1471-4159.2005.03574.X	0.398
2006	Schroeder CI, Lewis RJ. ω-Conotoxins GVIA, MVIIA and CVID: SAR and Clinical Potential. Marine Drugs. 4: 193-214. DOI: 10.3390/Md403193	0.311
2006	Nicholson GM, Lewis RJ. Ciguatoxins: Cyclic Polyether Modulators of Voltage-gated Iion Channel Function. Marine Drugs. 4: 82-118. DOI: 10.3390/Md403082	0.32
2006	Baell JB, Duggan PJ, Forsyth SA, Lewis RJ, Lok YP, Schroeder CI, Shepherd NE. Synthesis and biological evaluation of anthranilamide-based non-peptide mimetics of ω-conotoxin GVIA Tetrahedron. 62: 7284-7292. DOI: 10.1016/J.Tet.2006.05.041	0.314
2006	Brust A, Alewood D, Colless B, Palant E, Patterson B, Wilson DTR, Watson F, Schroeder CI, Alewood PF, Lewis RJ. conopeptide to drug: the development, structure and activity correlation of Xen2174 Journal of Peptide Science. 12: 516-516. DOI: 10.1002/Psc.797	0.347
2005	Nilsson KP, Lovelace ES, Caesar CE, TynngÃ¥rd N, Alewood PF, Johansson HM, Sharpe IA, Lewis RJ, Daly NL, Craik DJ. Solution structure of chi-conopeptide MrIA, a modulator of the human norepinephrine transporter. Biopolymers. 80: 815-23. PMID 15931669 DOI: 10.1002/Bip.20302	0.328
2005	Lima V, Mueller A, Kamikihara SY, Raymundi V, Alewood D, Lewis RJ, Chen Z, Minneman KP, Pupo AS. Differential antagonism by conotoxin rho-TIA of contractions mediated by distinct alpha1-adrenoceptor subtypes in rat vas deferens, spleen and aorta. European Journal of Pharmacology. 508: 183-92. PMID 15680270 DOI: 10.1016/J.Ejphar.2004.12.011	0.309
2004	Baell JB, Duggan PJ, Forsyth SA, Lewis RJ, Lok YP, Schroeder CI. Synthesis and biological evaluation of nonpeptide mimetics of omega-conotoxin GVIA. Bioorganic & Medicinal Chemistry. 12: 4025-37. PMID 15246080 DOI: 10.1016/J.Bmc.2004.05.040	0.318
2004	Yasuda T, Chen L, Barr W, McRory JE, Lewis RJ, Adams DJ, Zamponi GW. Auxiliary subunit regulation of high-voltage activated calcium channels expressed in mammalian cells. The European Journal of Neuroscience. 20: 1-13. PMID 15245474 DOI: 10.1111/J.1460-9568.2004.03434.X	0.442
2004	Schroeder CI, Smythe ML, Lewis RJ. Development of small molecules that mimic the binding of ω-conotoxins at the N-type voltage-gated calcium channel Molecular Diversity. 8: 127-134. PMID 15209164 DOI: 10.1023/B:Modi.0000025656.79632.86	0.359
2004	Dutertre S, Lewis RJ. Computational approaches to understand alpha-conotoxin interactions at neuronal nicotinic receptors. Febs Journal. 271: 2327-2334. PMID 15182348 DOI: 10.1111/J.1432-1033.2004.04147.X	0.311
2004	Mould J, Yasuda T, Schroeder CI, Beedle AM, Doering CJ, Zamponi GW, Adams DJ, Lewis RJ. The alpha2delta auxiliary subunit reduces affinity of omega-conotoxins for recombinant N-type (Cav2.2) calcium channels. The Journal of Biological Chemistry. 279: 34705-14. PMID 15166237 DOI: 10.1074/Jbc.M310848200	0.455
2004	Kloda A, Clements JD, Lewis RJ, Adams DJ. Adenosine triphosphate acts as both a competitive antagonist and a positive allosteric modulator at recombinant N-methyl-D-aspartate receptors. Molecular Pharmacology. 65: 1386-96. PMID 15155832 DOI: 10.1124/Mol.65.6.1386	0.417
2004	Lewis RJ. Conotoxins as selective inhibitors of neuronal ion channels, receptors and transporters Iubmb Life. 56: 89-93. PMID 15085932 DOI: 10.1080/15216540410001668055	0.348
2004	Daly NL, Ekberg JA, Thomas L, Adams DJ, Lewis RJ, Craik DJ. Structures of muO-conotoxins from Conus marmoreus. I nhibitors of tetrodotoxin (TTX)-sensitive and TTX-resistant sodium channels in mammalian sensory neurons. The Journal of Biological Chemistry. 279: 25774-82. PMID 15044438 DOI: 10.1074/Jbc.M313002200	0.48
2004	Yasuda T, Lewis RJ, Adams DJ. Overexpressed Ca(v)beta3 inhibits N-type (Cav2.2) calcium channel currents through a hyperpolarizing shift of ultra-slow and closed-state inactivation. The Journal of General Physiology. 123: 401-16. PMID 15024042 DOI: 10.1085/Jgp.200308967	0.42
2004	Loughnan ML, Nicke A, Jones A, Adams DJ, Alewood PF, Lewis RJ. Chemical and functional identification and characterization of novel sulfated alpha-conotoxins from the cone snail Conus anemone. Journal of Medicinal Chemistry. 47: 1234-41. PMID 14971903 DOI: 10.1021/Jm031010O	0.452
2004	Ragnarsson LK, Yasuda T, Adams DJ, Lewis RJ, Dodd PR. NMDA receptor variant responses to conantokins Journal of Neurochemistry. 88: 67-67. DOI: 10.1046/J.1474-1644.2003.2314P26_01.X	0.409
2003	Pottier I, Hamilton B, Jones A, Lewis RJ, Vernoux JP. Identification of slow and fast-acting toxins in a highly ciguatoxic barracuda (Sphyraena barracuda) by HPLC/MS and radiolabelled ligand binding. Toxicon : Official Journal of the International Society On Toxinology. 42: 663-72. PMID 14602122 DOI: 10.1016/J.Toxicon.2003.09.004	0.304
2003	Lewis RJ, Garcia ML. Therapeutic potential of venom peptides Nature Reviews Drug Discovery. 2: 790-802. PMID 14526382 DOI: 10.1038/Nrd1197	0.301
2003	Sharpe IA, Palant E, Schroeder CI, Kaye DM, Adams DJ, Alewood PF, Lewis RJ. Inhibition of the norepinephrine transporter by the venom peptide chi-MrIA. Site of action, Na+ dependence, and structure-activity relationship. The Journal of Biological Chemistry. 278: 40317-23. PMID 12885787 DOI: 10.1074/Jbc.M213030200	0.462
2003	Sharpe IA, Thomas L, Loughnan M, Motin L, Palant E, Croker DE, Alewood D, Chen S, Graham RM, Alewood PF, Adams DJ, Lewis RJ. Allosteric alpha 1-adrenoreceptor antagonism by the conopeptide rho-TIA. The Journal of Biological Chemistry. 278: 34451-7. PMID 12824165 DOI: 10.1074/Jbc.M305410200	0.45
2003	Blanchfield JT, Dutton JL, Hogg RC, Gallagher OP, Craik DJ, Jones A, Adams DJ, Lewis RJ, Alewood PF, Toth I. Synthesis, structure elucidation, in vitro biological activity, toxicity, and Caco-2 cell permeability of lipophilic analogues of alpha-conotoxin MII. Journal of Medicinal Chemistry. 46: 1266-72. PMID 12646037 DOI: 10.1021/Jm020426J	0.476
2003	Adams DJ, Smith AB, Schroeder CI, Yasuda T, Lewis RJ. Omega-conotoxin CVID inhibits a pharmacologically distinct voltage-sensitive calcium channel associated with transmitter release from preganglionic nerve terminals. The Journal of Biological Chemistry. 278: 4057-62. PMID 12441339 DOI: 10.1074/Jbc.M209969200	0.444
2003	Nicke A, Loughnan ML, Millard EL, Alewood PF, Adams DJ, Daly NL, Craik DJ, Lewis RJ. Isolation, structure, and activity of GID, a novel alpha 4/7-conotoxin with an extended N-terminal sequence. The Journal of Biological Chemistry. 278: 3137-44. PMID 12419800 DOI: 10.1074/Jbc.M210280200	0.406
2002	Hogg RC, Lewis RJ, Adams DJ. Ciguatoxin-induced oscillations in membrane potential and action potential firing in rat parasympathetic neurons. The European Journal of Neuroscience. 16: 242-8. PMID 12169106 DOI: 10.1046/J.1460-9568.2002.02071.X	0.401
2002	Nielsen KJ, Watson M, Adams DJ, Hammarström AK, Gage PW, Hill JM, Craik DJ, Thomas L, Adams D, Alewood PF, Lewis RJ. Solution structure of mu-conotoxin PIIIA, a preferential inhibitor of persistent tetrodotoxin-sensitive sodium channels. The Journal of Biological Chemistry. 277: 27247-55. PMID 12006587 DOI: 10.1074/Jbc.M201611200	0.472
2001	Sharpe IA, Gehrmann J, Loughnan ML, Thomas L, Adams DA, Atkins A, Palant E, Craik DJ, Adams DJ, Alewood PF, Lewis RJ. Two new classes of conopeptides inhibit the alpha1-adrenoceptor and noradrenaline transporter. Nature Neuroscience. 4: 902-7. PMID 11528421 DOI: 10.1038/Nn0901-902	0.455
2001	Blanchfield J, Dutton J, Hogg R, Craik D, Adams D, Lewis R, Alewood P, Toth I. The synthesis and structure of an n-terminal dodecanoic acid conjugate of α-conotoxin MII Letters in Peptide Science. 8: 235-239. DOI: 10.1023/A:1016577832311	0.459
2000	Hewitt L, Kasche V, Lummer K, Lewis RJ, Murshudov GN, Verma CS, Dodson GG, Wilson KS. Structure of a slow processing precursor penicillin acylase from Escherichia coli reveals the linker peptide blocking the active-site cleft. Journal of Molecular Biology. 302: 887-98. PMID 10993730 DOI: 10.1006/Jmbi.2000.4105	0.326
2000	Lewis RJ, Nielsen KJ, Craik DJ, Loughnan ML, Adams DA, Sharpe IA, Luchian T, Adams DJ, Bond T, Thomas L, Jones A, Matheson JL, Drinkwater R, Andrews PR, Alewood PF. Novel omega-conotoxins from Conus catus discriminate among neuronal calcium channel subtypes. The Journal of Biological Chemistry. 275: 35335-44. PMID 10938268 DOI: 10.1074/Jbc.M002252200	0.448
2000	Hill JM, Atkins AR, Loughnan ML, Jones A, Adams DA, Martin RC, Lewis RJ, Craik DJ, Alewood PF. Conotoxin TVIIA, a novel peptide from the venom of Conus tulipa 1. Isolation, characterization and chemical synthesis. European Journal of Biochemistry / Febs. 267: 4642-8. PMID 10903496 DOI: 10.1046/J.1432-1327.2000.01508.X	0.341
2000	Nielsen KJ, Schroeder T, Lewis R. Structure-activity relationships of omega-conotoxins at N-type voltage-sensitive calcium channels. Journal of Molecular Recognition : Jmr. 13: 55-70. PMID 10822250 DOI: 10.1002/(Sici)1099-1352(200003/04)13:2<55::Aid-Jmr488>3.0.Co;2-O	0.351
2000	Lewis RJ, Muchová K, Brannigan JA, Barák I, Leonard G, Wilkinson AJ. Domain swapping in the sporulation response regulator Spo0A. Journal of Molecular Biology. 297: 757-70. PMID 10731426 DOI: 10.1006/Jmbi.2000.3598	0.306
2000	Lewis RJ. Ion channel toxins and therapeutics: From cone snail venoms to ciguatera Therapeutic Drug Monitoring. 22: 61-64. PMID 10688261 DOI: 10.1097/00007691-200002000-00013	0.318
1999	Hogg RC, Miranda LP, Craik DJ, Lewis RJ, Alewood PF, Adams DJ. Single amino acid substitutions in alpha-conotoxin PnIA shift selectivity for subtypes of the mammalian neuronal nicotinic acetylcholine receptor. The Journal of Biological Chemistry. 274: 36559-64. PMID 10593955 DOI: 10.1074/Jbc.274.51.36559	0.441
1999	Nielsen KJ, Adams D, Thomas L, Bond T, Alewood PF, Craik DJ, Lewis RJ. Structure-activity relationships of omega-conotoxins MVIIA, MVIIC and 14 loop splice hybrids at N and P/Q-type calcium channels. Journal of Molecular Biology. 289: 1405-21. PMID 10373375 DOI: 10.1006/Jmbi.1999.2817	0.48
1999	Nielsen KJ, Adams DA, Alewood PF, Lewis RJ, Thomas L, Schroeder T, Craik DJ. Effects of chirality at Tyr13 on the structure-activity relationships of omega-conotoxins from Conus magus. Biochemistry. 38: 6741-51. PMID 10346894 DOI: 10.1021/Bi982980U	0.331
1999	Adams DJ, Alewood PF, Craik DJ, Drinkwater RD, Lewis RJ. Conotoxins and their potential pharmaceutical applications Drug Development Research. 46: 219-234. DOI: 10.1002/(Sici)1098-2299(199903/04)46:3/4<219::Aid-Ddr7>3.0.Co;2-S	0.463
1998	Hogg RC, Lewis RJ, Adams DJ. Ciguatoxin (CTX-1) modulates single tetrodotoxin-sensitive sodium channels in rat parasympathetic neurones. Neuroscience Letters. 252: 103-6. PMID 9756332 DOI: 10.1016/S0304-3940(98)00575-8	0.434
1998	Hu SH, Loughnan M, Miller R, Weeks CM, Blessing RH, Alewood PF, Lewis RJ, Martin JL. The 1.1 A resolution crystal structure of [Tyr15]EpI, a novel alpha-conotoxin from Conus episcopatus, solved by direct methods. Biochemistry. 37: 11425-33. PMID 9708977 DOI: 10.1021/Bi9806549	0.345
1998	Loughnan M, Bond T, Atkins A, Cuevas J, Adams DJ, Broxton NM, Livett BG, Down JG, Jones A, Alewood PF, Lewis RJ. alpha-conotoxin EpI, a novel sulfated peptide from Conus episcopatus that selectively targets neuronal nicotinic acetylcholine receptors. The Journal of Biological Chemistry. 273: 15667-74. PMID 9624161 DOI: 10.1074/Jbc.273.25.15667	0.471
1997	Scanlon MJ, Naranjo D, Thomas L, Alewood PF, Lewis RJ, Craik DJ. Solution structure and proposed binding mechanism of a novel potassium channel toxin kappa-conotoxin PVIIA. Structure (London, England : 1993). 5: 1585-97. PMID 9438859 DOI: 10.1016/S0969-2126(97)00307-9	0.325
1997	Poli MA, Lewis RJ, Dickey RW, Musser SM, Buckner CA, Carpenter LG. Identification of Caribbean ciguatoxins as the cause of an outbreak of fish poisoning among U.S. soldiers in Haiti. Toxicon : Official Journal of the International Society On Toxinology. 35: 733-41. PMID 9203298 DOI: 10.1016/S0041-0101(96)00166-3	0.307
1997	Skjaerbaek N, Nielsen KJ, Lewis RJ, Alewood P, Craik DJ. Determination of the solution structures of conantokin-G and conantokin-T by CD and NMR spectroscopy. The Journal of Biological Chemistry. 272: 2291-9. PMID 8999936 DOI: 10.1074/Jbc.272.4.2291	0.306
1996	Nielsen KJ, Thomas L, Lewis RJ, Alewood PF, Craik DJ. A consensus structure for omega-conotoxins with different selectivities for voltage-sensitive calcium channel subtypes: comparison of MVIIA, SVIB and SNX-202. Journal of Molecular Biology. 263: 297-310. PMID 8913308 DOI: 10.1006/Jmbi.1996.0576	0.357
1992	Lewis RJ. Ciguatoxins are potent ichthyotoxins Toxicon. 30: 207-211. PMID 1557790 DOI: 10.1016/0041-0101(92)90474-J	0.313
Low-probability matches (unlikely to be authored by this person)
2020	Himaya SWA, Rai SK, Pamfili G, Jin A, Alewood PF, Lewis RJ. Venomic Interrogation Reveals the Complexity of Conus striolatus Venom Australian Journal of Chemistry. 73: 357-365. DOI: 10.1071/Ch19588	0.3
2018	Wang D, Ragnarsson L, Lewis RJ. Insight into T-type calcium channel structure, function and modulation. Current Medicinal Chemistry. PMID 30277145 DOI: 10.2174/0929867325666181001112821	0.3
2008	Dutertre S, Croker D, Daly NL, Andersson A, Muttenthaler M, Lumsden NG, Craik DJ, Alewood PF, Guillon G, Lewis RJ. Conopressin-T from Conus tulipa reveals an antagonist switch in vasopressin-like peptides. The Journal of Biological Chemistry. 283: 7100-8. PMID 18174156 DOI: 10.1074/Jbc.M706477200	0.3
2015	Patel R, Brice NL, Lewis RJ, Dickenson AH. Ionic Mechanisms of Spinal Neuronal Cold Hypersensitivity in Ciguatera. The European Journal of Neuroscience. PMID 26454262 DOI: 10.1111/Ejn.13098	0.3
1995	Manger RL, Leja LS, Lee SY, Hungerford JM, Hokama Y, Dickey RW, Granade HR, Lewis R, Yasumoto T, Wekell MM. Detection of Sodium Channel Toxins: Directed Cytotoxicity Assays of Purified Ciguatoxins, Brevetoxins, Saxitoxins, and Seafood Extracts Journal of Aoac International. 78: 521-527. DOI: 10.1093/Jaoac/78.2.521	0.299
1998	Lewis RJ, Brannigan JA, Offen WA, Smith I, Wilkinson AJ. An evolutionary link between sporulation and prophage induction in the structure of a repressor:anti-repressor complex. Journal of Molecular Biology. 283: 907-12. PMID 9799632 DOI: 10.1006/Jmbi.1998.2163	0.299
2014	Dutertre S, Jin AH, Vetter I, Hamilton B, Sunagar K, Lavergne V, Dutertre V, Fry BG, Antunes A, Venter DJ, Alewood PF, Lewis RJ. Evolution of separate predation- and defence-evoked venoms in carnivorous cone snails. Nature Communications. 5: 3521. PMID 24662800 DOI: 10.1038/Ncomms4521	0.299
2012	Pagett HE, Abrahams JL, Bones J, O'Donoghue N, Marles-Wright J, Lewis RJ, Harris JR, Caldwell GS, Rudd PM, Clare AS. Structural characterisation of the N-glycan moiety of the barnacle settlement-inducing protein complex (SIPC). The Journal of Experimental Biology. 215: 1192-8. PMID 22399665 DOI: 10.1242/Jeb.063503	0.298
2001	Ducros VM, Lewis RJ, Verma CS, Dodson EJ, Leonard G, Turkenburg JP, Murshudov GN, Wilkinson AJ, Brannigan JA. Crystal structure of GerE, the ultimate transcriptional regulator of spore formation in Bacillus subtilis. Journal of Molecular Biology. 306: 759-71. PMID 11243786 DOI: 10.1006/Jmbi.2001.4443	0.298
1994	Holmes MJ, Lewis RJ. Purification and characterisation of large and small maitotoxins from cultured gambierdiscus toxicus Natural Toxins. 2: 64-72. PMID 8075895 DOI: 10.1002/Nt.2620020204	0.297
2005	Birinyi-Strachan LC, Gunning SJ, Lewis RJ, Nicholson GM. Block of voltage-gated potassium channels by Pacific ciguatoxin-1 contributes to increased neuronal excitability in rat sensory neurons. Toxicology and Applied Pharmacology. 204: 175-186. PMID 15808523 DOI: 10.1016/J.Taap.2004.08.020	0.297
2000	Lewis RJ, Krzywda S, Brannigan JA, Turkenburg JP, Muchová K, Dodson EJ, Barák I, Wilkinson AJ. The trans‐activation domain of the sporulation response regulator Spo0A revealed by X‐ray crystallography Molecular Microbiology. 38: 198-212. PMID 11069648 DOI: 10.1046/J.1365-2958.2000.02134.X	0.297
2016	Abraham N, Paul B, Ragnarsson L, Lewis RJ. Escherichia coli Protein Expression System for Acetylcholine Binding Proteins (AChBPs). Plos One. 11: e0157363. PMID 27304486 DOI: 10.1371/Journal.Pone.0157363	0.296
2014	Prashanth JR, Brust A, Jin AH, Alewood PF, Dutertre S, Lewis RJ. Cone snail venomics: from novel biology to novel therapeutics. Future Medicinal Chemistry. 6: 1659-75. PMID 25406006 DOI: 10.4155/Fmc.14.99	0.296
2005	Birinyi-Strachan LC, Davies MJ, Lewis RJ, Nicholson GM. Neuroprotectant effects of iso-osmolar D-mannitol to prevent Pacific ciguatoxin-1 induced alterations in neuronal excitability: A comparison with other osmotic agents and free radical scavengers Neuropharmacology. 49: 669-686. PMID 15950247 DOI: 10.1016/J.Neuropharm.2005.04.024	0.295
2015	Le Garrec R, L'herondelle K, Le Gall-Ianotto C, Lebonvallet N, Leschiera R, Buhe V, Talagas M, Vetter I, Lewis RJ, Misery L. Release of neuropeptides from a neuro-cutaneous co-culture model: a novel in vitro model for studying sensory effects of ciguatoxins. Toxicon : Official Journal of the International Society On Toxinology. PMID 26562445 DOI: 10.1016/J.Toxicon.2015.11.004	0.295
2014	Mehne FM, SchrÃ¶der-Tittmann K, Eijlander RT, Herzberg C, Hewitt L, Kaever V, Lewis RJ, Kuipers OP, Tittmann K, StÃ¼lke J. Control of the diadenylate cyclase CdaS in Bacillus subtilis: an autoinhibitory domain limits cyclic di-AMP production. The Journal of Biological Chemistry. 289: 21098-107. PMID 24939848 DOI: 10.1074/Jbc.M114.562066	0.295
2019	Halbedel S, Lewis RJ. Structural basis for interaction of DivIVA/GpsB proteins with their ligands. Molecular Microbiology. PMID 30887576 DOI: 10.1111/Mmi.14244	0.295
1986	Lewis RJ, Endean R. Direct and indirect effects of ciguatoxin on guinea-pig atria and papillary muscles. Naunyn-Schmiedebergs Archives of Pharmacology. 334: 313-322. PMID 2433605 DOI: 10.1007/Bf00508787	0.295
1993	Lewis RJ, Hoy AW. Comparative action of three major ciguatoxins on guinea-pig atria and ilea. Toxicon : Official Journal of the International Society On Toxinology. 31: 437-46. PMID 8503132 DOI: 10.1016/0041-0101(93)90179-M	0.294
1991	Lewis RJ, Sellin M, Poli MA, Norton RS, MacLeod JK, Sheil MM. Purification and characterization of ciguatoxins from moray eel (Lycodontis javanicus, Muraenidae). Toxicon. 29: 1115-1127. PMID 1665604 DOI: 10.1016/0041-0101(91)90209-A	0.294
2011	Cartmell A, McKee LS, PeÃ±a MJ, Larsbrink J, Brumer H, Kaneko S, Ichinose H, Lewis RJ, ViksÃ¸-Nielsen A, Gilbert HJ, Marles-Wright J. The structure and function of an arabinan-specific alpha-1,2-arabinofuranosidase identified from screening the activities of bacterial GH43 glycoside hydrolases. The Journal of Biological Chemistry. 286: 15483-95. PMID 21339299 DOI: 10.1074/Jbc.M110.215962	0.294
2004	Muchová K, Lewis RJ, Perečko D, Brannigan JA, Ladds JC, Leech A, Wilkinson AJ, Barák I. Dimer-induced signal propagation in Spo0A Molecular Microbiology. 53: 829-842. PMID 15255896 DOI: 10.1111/J.1365-2958.2004.04171.X	0.293
2008	Dumon C, Varvak A, Wall MA, Flint JE, Lewis RJ, Lakey JH, Morland C, Luginbühl P, Healey S, Todaro T, DeSantis G, Sun M, Parra-Gessert L, Tan X, Weiner DP, et al. Engineering hyperthermostability into a GH11 xylanase is mediated by subtle changes to protein structure. The Journal of Biological Chemistry. 283: 22557-64. PMID 18515360 DOI: 10.1074/Jbc.M800936200	0.293
1996	Lewis RJ, Singh OM, Smith CV, Skarzynski T, Maxwell A, Wonacott AJ, Wigley DB. The nature of inhibition of DNA gyrase by the coumarins and the cyclothialidines revealed by X-ray crystallography. The Embo Journal. 15: 1412-1420. DOI: 10.1002/J.1460-2075.1996.Tb00483.X	0.293
1997	Davies GJ, Ducros V, Lewis RJ, Borchert TV, Schülein M. Oligosaccharide specificity of a family 7 endoglucanase: insertion of potential sugar-binding subsites. Journal of Biotechnology. 57: 91-100. PMID 9335168 DOI: 10.1016/S0168-1656(97)00092-8	0.293
2004	Nicke A, Wonnacott S, Lewis RJ. α-Conotoxins as tools for the elucidation of structure and function of neuronal nicotinic acetylcholine receptor subtypes European Journal of Biochemistry. 271: 2305-2319. PMID 15182346 DOI: 10.1111/J.1432-1033.2004.04145.X	0.293
2014	Jean NL, Bougault CM, Lodge A, Derouaux A, Callens G, Egan AJ, Ayala I, Lewis RJ, Vollmer W, Simorre JP. Elongated structure of the outer-membrane activator of peptidoglycan synthesis LpoA: implications for PBP1A stimulation. Structure (London, England : 1993). 22: 1047-54. PMID 24954617 DOI: 10.1016/J.Str.2014.04.017	0.293
1999	Monn JA, Valli MJ, Massey SM, Hansen MM, Kress TJ, Wepsiec JP, Harkness AR, Grutsch JL, Wright RA, Johnson BG, Andis SL, Kingston A, Tomlinson R, Lewis R, Griffey KR, et al. Synthesis, pharmacological characterization, and molecular modeling of heterobicyclic amino acids related to (+)-2-aminobicyclo[3.1.0] hexane-2,6-dicarboxylic acid (LY354740): identification of two new potent, selective, and systemically active agonists for group II metabotropic glutamate receptors. Journal of Medicinal Chemistry. 42: 1027-40. PMID 10090786 DOI: 10.1021/Jm980616N	0.292
2003	Milne TJ, Abbenante G, Tyndall JD, Halliday J, Lewis RJ. Isolation and characterization of a cone snail protease with homology to CRISP proteins of the pathogenesis-related protein superfamily. The Journal of Biological Chemistry. 278: 31105-10. PMID 12759345 DOI: 10.1074/Jbc.M304843200	0.292
2009	Andersson A, Baell JB, Duggan PJ, Graham JE, Lewis RJ, Lumsden NG, Tranberg CE, Tuck KL, Yang A. Omega-conotoxin GVIA mimetics based on an anthranilamide core: effect of variation in ammonium side chain lengths and incorporation of fluorine. Bioorganic & Medicinal Chemistry. 17: 6659-70. PMID 19683451 DOI: 10.1016/J.Bmc.2009.07.063	0.291
1997	Vernoux J, Lewis RJ. Isolation and characterisation of Caribbean ciguatoxins from the horse-eye jack (Caranx latus). Toxicon. 35: 889-900. PMID 9241783 DOI: 10.1016/S0041-0101(96)00191-2	0.29
2004	Delumeau O, Dutta S, Brigulla M, Kuhnke G, Hardwick SW, Völker U, Yudkin MD, Lewis RJ. Functional and structural characterization of RsbU, a stress signaling protein phosphatase 2C. The Journal of Biological Chemistry. 279: 40927-37. PMID 15263010 DOI: 10.1074/Jbc.M405464200	0.29
2009	Duggan PJ, Lewis RJ, Phei Lok Y, Lumsden NG, Tuck KL, Yang A. Low molecular weight non-peptide mimics of omega-conotoxin GVIA. Bioorganic & Medicinal Chemistry Letters. 19: 2763-5. PMID 19362476 DOI: 10.1016/J.Bmcl.2009.03.130	0.29
2004	Dutertre S, Nicke A, Tyndall JD, Lewis RJ. Determination of alpha-conotoxin binding modes on neuronal nicotinic acetylcholine receptors. Journal of Molecular Recognition : Jmr. 17: 339-47. PMID 15227641 DOI: 10.1002/Jmr.683	0.29
2011	Correia MA, Mazumder K, Brás JL, Firbank SJ, Zhu Y, Lewis RJ, York WS, Fontes CM, Gilbert HJ. Structure and function of an arabinoxylan-specific xylanase. The Journal of Biological Chemistry. 286: 22510-20. PMID 21378160 DOI: 10.1074/Jbc.M110.217315	0.29
2000	Scott DJ, Leejeerajumnean S, Brannigan JA, Lewis RJ, Wilkinson AJ, Hoggett JG. Quaternary re-arrangement analysed by spectral enhancement: the interaction of a sporulation repressor with its antagonist. Journal of Molecular Biology. 293: 997-1004. PMID 10547280 DOI: 10.1006/Jmbi.1999.3221	0.29
2013	Lavergne V, Dutertre S, Jin AH, Lewis RJ, Taft RJ, Alewood PF. Systematic interrogation of the Conus marmoreus venom duct transcriptome with ConoSorter reveals 158 novel conotoxins and 13 new gene superfamilies. Bmc Genomics. 14: 708. PMID 24131469 DOI: 10.1186/1471-2164-14-708	0.289
2018	Conroy S, Kindon ND, Glenn J, Stoddart LA, Lewis RJ, Hill SJ, Kellam B, Stocks MJ. Synthesis and Evaluation of the first Fluorescent Antagonists of the Human P2YReceptor based on AR-C118925. Journal of Medicinal Chemistry. PMID 29558126 DOI: 10.1021/Acs.Jmedchem.8B00139	0.289
2009	Emami K, Topakas E, Nagy T, Henshaw J, Jackson KA, Nelson KE, Mongodin EF, Murray JW, Lewis RJ, Gilbert HJ. Regulation of the xylan-degrading apparatus of Cellvibrio japonicus by a novel two-component system. The Journal of Biological Chemistry. 284: 1086-96. PMID 18922794 DOI: 10.1074/Jbc.M805100200	0.289
2002	Smith MT, Cabot PJ, Ross FB, Robertson AD, Lewis RJ. The novel N-type calcium channel blocker, AM336, produces potent dose-dependent antinociception after intrathecal dosing in rats and inhibits substance P release in rat spinal cord slices. Pain. 96: 119-27. PMID 11932068 DOI: 10.1016/S0304-3959(01)00436-5	0.289
2016	Brust A, Croker DE, Colless B, Ragnarsson L, Andersson A, Jain K, Caraballo SG, Castro J, Brierley SM, Alewood PF, Lewis RJ. Conopeptide-derived κ-opioid agonists (conorphins): potent, selective and metabolic stable dynorphinA mimetics with anti-nociceptive properties. Journal of Medicinal Chemistry. PMID 26859603 DOI: 10.1021/Acs.Jmedchem.5B00911	0.289
2014	Mickiewicz KM, Gays F, Lewis RJ, Brooks CG. Mutagenesis of Ly49B reveals key structural elements required for promiscuous binding to MHC class I molecules and new insights into the molecular evolution of Ly49s. Journal of Immunology (Baltimore, Md. : 1950). 192: 1558-69. PMID 24403531 DOI: 10.4049/Jimmunol.1301643	0.289
2018	Raouf R, Lolignier S, Sexton JE, Millet Q, Santana-Varela S, Biller A, Fuller AM, Pereira V, Choudhary JS, Collins MO, Moss SE, Lewis R, Tordo J, Henckaerts E, Linden M, et al. Inhibition of somatosensory mechanotransduction by annexin A6. Science Signaling. 11. PMID 29921656 DOI: 10.1126/Scisignal.Aao2060	0.288
2017	Ward RA, Bethel PA, Cook C, Davies E, Debreczeni JÉ, Fairley G, Feron L, Flemington V, Graham MA, Greenwood R, Griffin N, Hanson L, Hopcroft P, Howard TD, Hudson J, ... ... Lewis RJ, et al. Structure-Guided Discovery of Potent and Selective Inhibitors of ERK1/2 from a Modestly Active and Promiscuous Chemical Start Point. Journal of Medicinal Chemistry. PMID 28376306 DOI: 10.1021/Acs.Jmedchem.7B00267	0.288
2003	Nicke A, Samochocki M, Loughnan ML, Bansal PS, Maelicke A, Lewis RJ. Alpha-conotoxins EpI and AuIB switch subtype selectivity and activity in native versus recombinant nicotinic acetylcholine receptors. Febs Letters. 554: 219-23. PMID 14596943 DOI: 10.1016/S0014-5793(03)01161-X	0.288
2006	Xie H, Flint J, Vardakou M, Lakey JH, Lewis RJ, Gilbert HJ, Dumon C. Probing the structural basis for the difference in thermostability displayed by family 10 xylanases. Journal of Molecular Biology. 360: 157-67. PMID 16762367 DOI: 10.1016/J.Jmb.2006.05.002	0.288
2012	Quin MB, Berrisford JM, Newman JA, Baslé A, Lewis RJ, Marles-Wright J. The bacterial stressosome: a modular system that has been adapted to control secondary messenger signaling. Structure (London, England : 1993). 20: 350-63. PMID 22325782 DOI: 10.1016/J.Str.2012.01.003	0.288
2012	Sousa SR, Ragnarsson L, Vetter I, Herzig V, King GF, Lewis RJ. 32. Development of High Throughput Calcium Channel Assays to Accelerate the Discovery of Novel Toxins Targeting Human Cav2.2 Channels Toxicon. 60: 111-111. DOI: 10.1016/J.Toxicon.2012.04.033	0.287
2019	Jin AH, Dutertre S, Dutt M, Lavergne V, Jones A, Lewis RJ, Alewood PF. Transcriptomic-Proteomic Correlation in the Predation-Evoked Venom of the Cone Snail, . Marine Drugs. 17. PMID 30893765 DOI: 10.3390/Md17030177	0.287
2017	Muttenthaler M, Andersson Å, Vetter I, Menon R, Busnelli M, Ragnarsson L, Bergmayr C, Arrowsmith S, Deuis JR, Chiu HS, Palpant NJ, O'Brien M, Smith TJ, Wray S, Neumann ID, ... ... Lewis RJ, et al. Subtle modifications to oxytocin produce ligands that retain potency and improved selectivity across species. Science Signaling. 10. PMID 29208680 DOI: 10.1126/Scisignal.Aan3398	0.287
2004	Jobling P, Gibbins IL, Lewis RJ, Morris JL. Differential expression of calcium channels in sympathetic and parasympathetic preganglionic inputs to neurons in paracervical ganglia of guinea-pigs. Neuroscience. 127: 455-66. PMID 15262335 DOI: 10.1016/J.Neuroscience.2004.05.005	0.287
2007	Hardwick SW, Pané-Farré J, Delumeau O, Marles-Wright J, Murray JW, Hecker M, Lewis RJ. Structural and functional characterization of partner switching regulating the environmental stress response in Bacillus subtilis. The Journal of Biological Chemistry. 282: 11562-72. PMID 17303566 DOI: 10.1074/Jbc.M609733200	0.287
2005	Murray JW, Delumeau O, Lewis RJ. Structure of a nonheme globin in environmental stress signaling. Proceedings of the National Academy of Sciences of the United States of America. 102: 17320-5. PMID 16301540 DOI: 10.1073/Pnas.0506599102	0.286
2011	Newman JA, Hewitt L, Rodrigues C, Solovyova A, Harwood CR, Lewis RJ. Unusual, dual endo- and exonuclease activity in the degradosome explained by crystal structure analysis of RNase J1. Structure (London, England : 1993). 19: 1241-51. PMID 21893285 DOI: 10.1016/J.Str.2011.06.017	0.286
2004	Morris JL, Ozols DI, Lewis RJ, Gibbins IL, Jobling P. Differential involvement of N-type calcium channels in transmitter release from vasoconstrictor and vasodilator neurons. British Journal of Pharmacology. 141: 961-70. PMID 14993106 DOI: 10.1038/Sj.Bjp.0705712	0.285
2001	Seavers PR, Lewis RJ, Brannigan JA, Verschueren KHG, Murshudov GN, Wilkinson AJ. Structure of the Bacillus Cell Fate Determinant SpoIIAA in Phosphorylated and Unphosphorylated Forms Structure. 9: 605-614. PMID 11470435 DOI: 10.1016/S0969-2126(01)00623-2	0.285
2009	Schirner K, Marles-Wright J, Lewis RJ, Errington J. Distinct and essential morphogenic functions for wall- and lipo-teichoic acids in Bacillus subtilis Embo Journal. 28: 830-842. PMID 19229300 DOI: 10.1038/Emboj.2009.25	0.284
2005	Tsai VW, Dodd PR, Lewis RJ. The effects of alanine-substituted conantokin-G and ifenprodil on the human spermine-activated N-methyl-D-aspartate receptor. Neuroscience. 130: 457-64. PMID 15664702 DOI: 10.1016/J.Neuroscience.2004.09.039	0.284
2014	Cleverley RM, Barrett JR, Baslé A, Bui NK, Hewitt L, Solovyova A, Xu ZQ, Daniel RA, Dixon NE, Harry EJ, Oakley AJ, Vollmer W, Lewis RJ. Structure and function of a spectrin-like regulator of bacterial cytokinesis. Nature Communications. 5: 5421. PMID 25403286 DOI: 10.1038/Ncomms6421	0.284
2005	Dutertre S, Nicke A, Lewis RJ. Beta2 subunit contribution to 4/7 alpha-conotoxin binding to the nicotinic acetylcholine receptor. The Journal of Biological Chemistry. 280: 30460-8. PMID 15929983 DOI: 10.1074/Jbc.M504229200	0.284
2008	Correia MA, Prates JA, Brás J, Fontes CM, Newman JA, Lewis RJ, Gilbert HJ, Flint JE. Crystal structure of a cellulosomal family 3 carbohydrate esterase from Clostridium thermocellum provides insights into the mechanism of substrate recognition. Journal of Molecular Biology. 379: 64-72. PMID 18436237 DOI: 10.1016/J.Jmb.2008.03.037	0.283
2011	Vetter I, Lewis RJ. Natural product ligands of TRP channels. Advances in Experimental Medicine and Biology. 704: 41-85. PMID 21290289 DOI: 10.1007/978-94-007-0265-3_3	0.283
2012	McKee LS, PeÃ±a MJ, Rogowski A, Jackson A, Lewis RJ, York WS, Krogh KB, ViksÃ¸-Nielsen A, SkjÃ¸t M, Gilbert HJ, Marles-Wright J. Introducing endo-xylanase activity into an exo-acting arabinofuranosidase that targets side chains. Proceedings of the National Academy of Sciences of the United States of America. 109: 6537-42. PMID 22492980 DOI: 10.1073/Pnas.1117686109	0.283
2008	Vardakou M, Dumon C, Murray JW, Christakopoulos P, Weiner DP, Juge N, Lewis RJ, Gilbert HJ, Flint JE. Understanding the structural basis for substrate and inhibitor recognition in eukaryotic GH11 xylanases. Journal of Molecular Biology. 375: 1293-305. PMID 18078955 DOI: 10.1016/J.Jmb.2007.11.007	0.283
2009	Fry BG, Roelants K, Champagne DE, Scheib H, Tyndall JD, King GF, Nevalainen TJ, Norman JA, Lewis RJ, Norton RS, Renjifo C, de la Vega RC. The toxicogenomic multiverse: convergent recruitment of proteins into animal venoms. Annual Review of Genomics and Human Genetics. 10: 483-511. PMID 19640225 DOI: 10.1146/Annurev.Genom.9.081307.164356	0.282
2016	Deuis JR, Wingerd JS, Winter Z, Durek T, Dekan Z, Sousa SR, Zimmermann K, Hoffmann T, Weidner C, Nassar MA, Alewood PF, Lewis RJ, Vetter I. Analgesic Effects of GpTx-1, PF-04856264 and CNV1014802 in a Mouse Model of NaV1.7-Mediated Pain. Toxins. 8. PMID 26999206 DOI: 10.3390/Toxins8030078	0.282
2009	Montanier C, van Bueren AL, Dumon C, Flint JE, Correia MA, Prates JA, Firbank SJ, Lewis RJ, Grondin GG, Ghinet MG, Gloster TM, Herve C, Knox JP, Talbot BG, Turkenburg JP, et al. Evidence that family 35 carbohydrate binding modules display conserved specificity but divergent function. Proceedings of the National Academy of Sciences of the United States of America. 106: 3065-70. PMID 19218457 DOI: 10.1073/Pnas.0808972106	0.282
2009	Davis J, Jones A, Lewis RJ. Remarkable inter- and intra-species complexity of conotoxins revealed by LC/MS. Peptides. 30: 1222-7. PMID 19540420 DOI: 10.1016/J.Peptides.2009.03.019	0.282
2019	Cleverley RM, Rutter ZJ, Rismondo J, Corona F, Tsui HT, Alatawi FA, Daniel RA, Halbedel S, Massidda O, Winkler ME, Lewis RJ. The cell cycle regulator GpsB functions as cytosolic adaptor for multiple cell wall enzymes. Nature Communications. 10: 261. PMID 30651563 DOI: 10.2210/Pdb6Gp7/Pdb	0.282
2015	Mollica A, Costante R, Novellino E, Stefanucci A, Pieretti S, Zador F, Samavati R, Borsodi A, Benyhe S, Vetter I, Lewis RJ. Design, Synthesis and Biological Evaluation of Two Opioid Agonist and Cav 2.2 Blocker Multitarget Ligands. Chemical Biology & Drug Design. 86: 156-62. PMID 25393330 DOI: 10.1111/Cbdd.12479	0.28
2002	Lewis RJ, Scott DJ, Brannigan JA, Ladds JC, Cervin MA, Spiegelman GB, Hoggett JG, Barák I, Wilkinson AJ. Dimer formation and transcription activation in the sporulation response regulator Spo0A. Journal of Molecular Biology. 316: 235-45. PMID 11851334 DOI: 10.1006/Jmbi.2001.5331	0.279
1982	Cameron AM, Lewis RJ. The antispasmogenic action on guinea-pig ileum of a fraction obtained from the toxic skin secretion of the stonefish, Synanceia trachynis Toxicon. 20: 991-1000. PMID 7164115 DOI: 10.1016/0041-0101(82)90101-5	0.279
2016	Lewis RJ, Inserra M, Vetter I, Holland WC, Hardison DR, Tester PA, Litaker RW. Rapid Extraction and Identification of Maitotoxin and Ciguatoxin-Like Toxins from Caribbean and Pacific Gambierdiscus Using a New Functional Bioassay. Plos One. 11: e0160006. PMID 27467390 DOI: 10.1371/Journal.Pone.0160006	0.279
1995	Hamblin PA, McLachlan EM, Lewis RJ. Sub-nanomolar concentrations of ciguatoxin-1 excite preganglionic terminals in guinea pig sympathetic ganglia. Naunyn-Schmiedeberg's Archives of Pharmacology. 352: 236-46. PMID 7477449 DOI: 10.1007/Bf00176780	0.278
2015	Murali SS, Napier IA, Mohammadi SA, Alewood PF, Lewis RJ, Christie MJ. High-voltage-activated calcium current subtypes in mouse DRG neurons adapt in a subpopulation-specific manner after nerve injury. Journal of Neurophysiology. 113: 1511-9. PMID 25505111 DOI: 10.1152/Jn.00608.2014	0.278
2015	Peterson EA, Teffera Y, Albrecht BK, Bauer D, Bellon SF, Boezio A, Boezio C, Broome MA, Choquette D, Copeland KW, Dussault I, Lewis R, Lin MH, Lohman J, Liu J, et al. Discovery of potent and selective 8-fluorotriazolopyridine c-Met inhibitors. Journal of Medicinal Chemistry. 58: 2417-30. PMID 25699405 DOI: 10.1021/Jm501913A	0.278
2019	Dutt M, Dutertre S, Jin AH, Lavergne V, Alewood PF, Lewis RJ. Venomics Reveals Venom Complexity of the Piscivorous Cone Snail, . Marine Drugs. 17. PMID 30669642 DOI: 10.3390/Md17010071	0.278
2006	Delumeau O, Chen CC, Murray JW, Yudkin MD, Lewis RJ. High-molecular-weight complexes of RsbR and paralogues in the environmental signaling pathway of Bacillus subtilis. Journal of Bacteriology. 188: 7885-92. PMID 16963570 DOI: 10.1128/Jb.00892-06	0.278
2014	Diethmaier C, Newman JA, KovÃ¡cs AT, Kaever V, Herzberg C, Rodrigues C, Boonstra M, Kuipers OP, Lewis RJ, StÃ¼lke J. The YmdB phosphodiesterase is a global regulator of late adaptive responses in Bacillus subtilis. Journal of Bacteriology. 196: 265-75. PMID 24163345 DOI: 10.1128/Jb.00826-13	0.277
2012	Marles-Wright J, Lewis RJ. The Bacillus subtilis stressosome: A signal integration and transduction hub. Communicative & Integrative Biology. 1: 182-4. PMID 19704888 DOI: 10.4161/Cib.1.2.7225	0.277
2010	Mattei C, Marquais M, Schlumberger S, Molgó J, Vernoux JP, Lewis RJ, Benoit E. Analysis of Caribbean ciguatoxin-1 effects on frog myelinated axons and the neuromuscular junction Toxicon. 56: 759-767. PMID 19646468 DOI: 10.1016/J.Toxicon.2009.07.026	0.277
1999	Nielsen KJ, Skjaerbaek N, Dooley M, Adams DA, Mortensen M, Dodd PR, Craik DJ, Alewood PF, Lewis RJ. Structure-activity studies of conantokins as human N-methyl-D-aspartate receptor modulators. Journal of Medicinal Chemistry. 42: 415-26. PMID 9986713 DOI: 10.1021/Jm981052Q	0.277
2009	Pané-Farré J, Jonas B, Hardwick SW, Gronau K, Lewis RJ, Hecker M, Engelmann S. Role of RsbU in controlling SigB activity in Staphylococcus aureus following alkaline stress. Journal of Bacteriology. 191: 2561-73. PMID 19201800 DOI: 10.1128/Jb.01514-08	0.277
1992	Lewis RJ, Hoy AW, McGiffin DC. Action of ciguatoxin on human atrial trabeculae. Toxicon : Official Journal of the International Society On Toxinology. 30: 907-14. PMID 1523682 DOI: 10.1016/0041-0101(92)90389-M	0.276
2012	Dutertre S, Jin A, Alewood PF, Lewis RJ. 99. The Venom of Conus geographus Revisited Toxicon. 60: 145. DOI: 10.1016/J.Toxicon.2012.04.100	0.276
2018	Wang D, Neupane P, Ragnarsson L, Capon RJ, Lewis RJ. Synthesis of Pseudellone Analogs and Characterization as Novel T-type Calcium Channel Blockers. Marine Drugs. 16. PMID 30487473 DOI: 10.3390/Md16120475	0.275
2017	Åsberg D, Langborg Weinmann A, Leek T, Lewis RJ, Klarqvist M, Leśko M, Kaczmarski K, Samuelsson J, Fornstedt T. The importance of ion-pairing in peptide purification by reversed-phase liquid chromatography. Journal of Chromatography. A. PMID 28363419 DOI: 10.1016/J.Chroma.2017.03.041	0.275
2014	Dutertre S, Jin AH, Alewood PF, Lewis RJ. Intraspecific variations in Conus geographus defence-evoked venom and estimation of the human lethal dose. Toxicon : Official Journal of the International Society On Toxinology. 91: 135-44. PMID 25301479 DOI: 10.1016/J.Toxicon.2014.09.011	0.275
2020	Jha P, Ragnarsson L, Lewis RJ. Structure-Function of the High Affinity Substrate Binding Site (S1) of Human Norepinephrine Transporter. Frontiers in Pharmacology. 11: 217. PMID 32210813 DOI: 10.3389/Fphar.2020.00217	0.274
2010	Wang CIA, Lewis RJ. Emerging structure-function relationships defining monoamine NSS transporter substrate and ligand affinity Biochemical Pharmacology. 79: 1083-1091. PMID 19954741 DOI: 10.1016/J.Bcp.2009.11.019	0.274
2018	Artelsmair M, Gu C, Lewis RJ, Elmore CS. Synthesis of C-14 Labeled GABAA α2/α3 Selective Partial Agonists and the Investigation of Late-Occurring and Long-Circulating Metabolites of GABAA Receptor Modulator AZD7325. Journal of Labelled Compounds & Radiopharmaceuticals. PMID 29314165 DOI: 10.1002/Jlcr.3602	0.273
2017	Pané-Farré J, Quin MB, Lewis RJ, Marles-Wright J. Structure and Function of the Stressosome Signalling Hub. Sub-Cellular Biochemistry. 83: 1-41. PMID 28271471 DOI: 10.1007/978-3-319-46503-6_1	0.273
2016	Eisenblätter A, Lewis R, Dörfler A, Forster C, Zimmermann K. Brain Mechanisms of Abnormal Temperature Perception in Cold Allodynia induced by Ciguatoxin. Annals of Neurology. PMID 27997033 DOI: 10.1002/Ana.24841	0.273
2012	Vetter I, Mozar CA, Durek T, Wingerd JS, Alewood PF, Christie MJ, Lewis RJ. Characterisation of Na(v) types endogenously expressed in human SH-SY5Y neuroblastoma cells. Biochemical Pharmacology. 83: 1562-71. PMID 22410003 DOI: 10.1016/J.Bcp.2012.02.022	0.273
2015	Rismondo J, Cleverley RM, Lane HV, Großhennig S, Steglich A, Möller L, Mannala GK, Hain T, Lewis RJ, Halbedel S. Structure of the bacterial cell division determinant GpsB and its interaction with penicillin binding proteins. Molecular Microbiology. PMID 26575090 DOI: 10.1111/Mmi.13279	0.272
2002	Hamilton B, Hurbungs M, Vernoux JP, Jones A, Lewis RJ. Isolation and characterisation of Indian Ocean ciguatoxin. Toxicon : Official Journal of the International Society On Toxinology. 40: 685-93. PMID 12175604 DOI: 10.1016/S0041-0101(01)00259-8	0.272
2017	Abraham N, Healy M, Ragnarsson L, Brust A, Alewood PF, Lewis RJ. Structural mechanisms for alpha-conotoxin activity at the human alpha 3 beta 4 nicotinic acetylcholine receptor. Scientific Reports. 7: 45466-45466. DOI: 10.2210/Pdb5T90/Pdb	0.272
2016	Cleverley RM, Rismondo J, Lockhart-Cairns MP, Van Bentum PT, Egan AJ, Vollmer W, Halbedel S, Baldock C, Breukink E, Lewis RJ. Subunit Arrangement in GpsB, a Regulator of Cell Wall Biosynthesis. Microbial Drug Resistance (Larchmont, N.Y.). PMID 27257764 DOI: 10.1089/Mdr.2016.0050	0.272
2010	Gunka K, Newman JA, Commichau FM, Herzberg C, Rodrigues C, Hewitt L, Lewis RJ, Stülke J. Functional dissection of a trigger enzyme: mutations of the bacillus subtilis glutamate dehydrogenase RocG that affect differentially its catalytic activity and regulatory properties. Journal of Molecular Biology. 400: 815-27. PMID 20630473 DOI: 10.1016/J.Jmb.2010.05.055	0.272
2002	Muchová K, Kutejová E, Scott DJ, Brannigan JA, Lewis RJ, Wilkinson AJ, Barák I. Oligomerization of the Bacillus subtilis division protein DivIVA. Microbiology (Reading, England). 148: 807-13. PMID 11882716 DOI: 10.1099/00221287-148-3-807	0.272
2000	Lehane L, Lewis RJ. Ciguatera: recent advances but the risk remains. International Journal of Food Microbiology. 61: 91-125. PMID 11078162 DOI: 10.1016/S0168-1605(00)00382-2	0.272
1993	Lewis RJ, Norton RS, Brereton IM, Eccles CD. Ciguatoxin-2 is a diastereomer of ciguatoxin-3 Toxicon. 31: 637-643. PMID 8332994 DOI: 10.1016/0041-0101(93)90118-3	0.271
2020	Wamp S, Rutter ZJ, Rismondo J, Jennings CE, Möller L, Lewis RJ, Halbedel S. PrkA controls peptidoglycan biosynthesis through the essential phosphorylation of ReoM. Elife. 9. PMID 32469310 DOI: 10.7554/Elife.56048	0.271
1996	Jones A, Bingham JP, Gehrmann J, Bond T, Loughnan M, Atkins A, Lewis RJ, Alewood PF. Isolation and characterization of conopeptides by high-performance liquid chromatography combined with mass spectrometry and tandem mass spectrometry. Rapid Communications in Mass Spectrometry : Rcm. 10: 138-43. PMID 8563013 DOI: 10.1002/(Sici)1097-0231(19960115)10:1<138::Aid-Rcm442>3.0.Co;2-3	0.271
1999	Lewis RJ, Brannigan JA, Muchová K, Barák I, Wilkinson AJ. Phosphorylated Aspartate In The Structure Of A Response Regulator Protein Journal of Molecular Biology. 294: 9-15. PMID 10556024 DOI: 10.1006/Jmbi.1999.3261	0.27
2019	Ragnarsson L, Andersson Å, Thomas WG, Lewis RJ. Mutations in the NPxxY motif stabilize pharmacologically distinct conformational states of the α- and β-adrenoceptors. Science Signaling. 12. PMID 30862702 DOI: 10.1126/Scisignal.Aas9485	0.27
2010	Lowe EC, Bydder S, Hartshorne RS, Tape HL, Dridge EJ, Debieux CM, Paszkiewicz K, Singleton I, Lewis RJ, Santini JM, Richardson DJ, Butler CS. Quinol-cytochrome c oxidoreductase and cytochrome c4 mediate electron transfer during selenate respiration in Thauera selenatis. The Journal of Biological Chemistry. 285: 18433-42. PMID 20388716 DOI: 10.1074/Jbc.M110.115873	0.27
1993	Logan D, Abu-Ghazaleh R, Blakemore W, Curry S, Jackson T, King A, Lea S, Lewis R, Newman J, Parry N. Structure of a major immunogenic site on foot-and-mouth disease virus. Nature. 362: 566-8. PMID 8385272 DOI: 10.1038/362566A0	0.27
2014	Karas JA, Scanlon DB, Forbes BE, Vetter I, Lewis RJ, Gardiner J, Separovic F, Wade JD, Hossain MA. 2-nitroveratryl as a photocleavable thiol-protecting group for directed disulfide bond formation in the chemical synthesis of insulin. Chemistry (Weinheim An Der Bergstrasse, Germany). 20: 9549-52. PMID 24957739 DOI: 10.1002/Chem.201403574	0.27
2013	Ghassemian A, Wang CI, Yau MK, Reid RC, Lewis RJ, Fairlie DP, Alewood PF, Durek T. Efficient chemical synthesis of human complement protein C3a. Chemical Communications (Cambridge, England). 49: 2356-8. PMID 23407800 DOI: 10.1039/C3Cc40537K	0.269
2007	Paczkowski FA, Sharpe IA, Dutertre S, Lewis RJ. chi-Conotoxin and tricyclic antidepressant interactions at the norepinephrine transporter define a new transporter model. The Journal of Biological Chemistry. 282: 17837-44. PMID 17428804 DOI: 10.1074/Jbc.M610813200	0.269
2015	Gori A, Wang CI, Harvey PJ, Rosengren KJ, Bhola RF, Gelmi ML, Longhi R, Christie MJ, Lewis RJ, Alewood PF, Brust A. Stabilization of the cysteine-rich conotoxin MrIA by using a 1,2,3-triazole as a disulfide bond mimetic. Angewandte Chemie (International Ed. in English). 54: 1361-4. PMID 25483297 DOI: 10.1002/Anie.201409678	0.269
2011	Morley AD, Cook A, King S, Roberts B, Lever S, Weaver R, Macdonald C, Unitt J, Fagura M, Phillips T, Lewis R, Wenlock M. Discovery of pyrazoles as novel FPR1 antagonists. Bioorganic & Medicinal Chemistry Letters. 21: 6456-60. PMID 21955939 DOI: 10.1016/J.Bmcl.2011.08.085	0.269
2007	Marles-Wright J, Lewis RJ. Stress responses of bacteria. Current Opinion in Structural Biology. 17: 755-60. PMID 17920859 DOI: 10.1016/J.Sbi.2007.08.004	0.268
1995	Brock JA, McLachlan EM, Jobling P, Lewis RJ. Electrical activity in rat tail artery during asynchronous activation of postganglionic nerve terminals by ciguatoxin-1. British Journal of Pharmacology. 116: 2213-20. PMID 8564251 DOI: 10.1111/J.1476-5381.1995.Tb15056.X	0.268
2007	Springthorpe B, Bailey A, Barton P, Birkinshaw TN, Bonnert RV, Brown RC, Chapman D, Dixon J, Guile SD, Humphries RG, Hunt SF, Ince F, Ingall AH, Kirk IP, Leeson PD, ... ... Lewis RJ, et al. From ATP to AZD6140: the discovery of an orally active reversible P2Y12 receptor antagonist for the prevention of thrombosis. Bioorganic & Medicinal Chemistry Letters. 17: 6013-8. PMID 17827008 DOI: 10.1016/J.Bmcl.2007.07.057	0.268
1993	Lewis RJ, Holmes MJ. Origin and transfer of toxins involved in ciguatera Comparative Biochemistry and Physiology Part C: Pharmacology, Toxicology and Endocrinology. 106: 615-628. PMID 7905799 DOI: 10.1016/0742-8413(93)90217-9	0.268
2003	Nicke A, Samochocki M, Loughnan ML, Bansal PS, Maelicke A, Lewis RJ. Corrigendum to: α-Conotoxins EpI and AuIB switch subtype selectivity and activity in native versus recombinant nicotinic acetylcholine receptors (FEBS 27779) Febs Letters. 557: 294-294. DOI: 10.1016/S0014-5793(03)01497-2	0.267
2016	Egan AJ, Cleverley RM, Peters K, Lewis RJ, Vollmer W. Regulation of bacterial cell wall growth. The Febs Journal. PMID 27862967 DOI: 10.1111/Febs.13959	0.266
2006	Dridge EJ, Richardson DJ, Lewis RJ, Butler CS. Developing structure-based models to predict substrate specificity of D-group (Type II) molybdenum enzymes: application to a molybdo-enzyme of unknown function from Archaeoglobus fulgidus. Biochemical Society Transactions. 34: 118-21. PMID 16417498 DOI: 10.1042/Bst0340118	0.266
2001	Seavers PR, Lewis RJ, Brannigan JA, Wilkinson AJ. Crystallization and preliminary X-ray analysis of the sporulation factor SpoIIAA in its native and phosphorylated forms. Acta Crystallographica Section D-Biological Crystallography. 57: 292-295. PMID 11173484 DOI: 10.1107/S090744490001859X	0.266
2017	Baslé A, Hewitt L, Koh A, Lamb HK, Thompson P, Burgess JG, Hall MJ, Hawkins AR, Murray H, Lewis RJ. Crystal structure of NucB, a biofilm-degrading endonuclease. Nucleic Acids Research. PMID 29165717 DOI: 10.1093/Nar/Gkx1170	0.266
2001	Lewis RJ. The changing face of ciguatera Toxicon. 39: 97-106. PMID 10936626 DOI: 10.1016/S0041-0101(00)00161-6	0.265
2015	Rodriguez AM, Dutertre S, Lewis RJ, Marí F. Intraspecific variations in Conus purpurascens injected venom using LC/MALDI-TOF-MS and LC-ESI-TripleTOF-MS. Analytical and Bioanalytical Chemistry. 407: 6105-16. PMID 26048056 DOI: 10.1007/S00216-015-8787-Y	0.265
2004	Dong TC, Cutting SM, Lewis RJ. DNA-binding studies on the Bacillus subtilis transcriptional regulator and AbrB homologue, SpoVT Fems Microbiology Letters. 233: 247-256. PMID 15063493 DOI: 10.1016/J.Femsle.2004.02.013	0.265
2005	Vardakou M, Flint J, Christakopoulos P, Lewis RJ, Gilbert HJ, Murray JW. A family 10 Thermoascus aurantiacus xylanase utilizes arabinose decorations of xylan as significant substrate specificity determinants. Journal of Molecular Biology. 352: 1060-7. PMID 16140328 DOI: 10.1016/J.Jmb.2005.07.051	0.265
2006	Pané-Farré J, Lewis RJ, Stülke J. The RsbRST stress module in bacteria: a signalling system that may interact with different output modules. Journal of Molecular Microbiology and Biotechnology. 9: 65-76. PMID 16319496 DOI: 10.1159/000088837	0.265
2008	Firbank SJ, Wardle J, Heslop P, Lewis RJ, Connolly BA. Uracil Recognition in Archaeal DNA Polymerases Captured by X-ray Crystallography Journal of Molecular Biology. 381: 529-539. PMID 18614176 DOI: 10.1016/J.Jmb.2008.06.004	0.265
2010	Muttenthaler M, Andersson A, de Araujo AD, Dekan Z, Lewis RJ, Alewood PF. Modulating oxytocin activity and plasma stability by disulfide bond engineering. Journal of Medicinal Chemistry. 53: 8585-96. PMID 21117646 DOI: 10.1021/Jm100989W	0.265
2013	Newman JA, Rodrigues C, Lewis RJ. Molecular basis of the activity of SinR protein, the master regulator of biofilm formation in Bacillus subtilis. The Journal of Biological Chemistry. 288: 10766-78. PMID 23430750 DOI: 10.1074/Jbc.M113.455592	0.265
2002	Ragnarsson L, Mortensen M, Dodd PR, Lewis RJ. Spermine modulation of the glutamate(NMDA) receptor is differentially responsive to conantokins in normal and Alzheimer's disease human cerebral cortex. Journal of Neurochemistry. 81: 765-79. PMID 12065636 DOI: 10.1046/J.1471-4159.2002.00872.X	0.265
1999	Scott DJ, Leejeerajumnean S, Brannigan JA, Lewis RJ, Wilkinson AJ, Hoggett JG. Towards deconvoluting the interaction of the Bacillus subtilis sporulation proteins SinR and SinI using tryptophan analogue incorporated proteins Progress in Colloid and Polymer Science. 209-211. DOI: 10.1007/3-540-48703-4_31	0.265
2000	Schmeisser F, Brannigan JA, Lewis RJ, Wilkinson AJ, Youngman P, Barák I. A new mutation in spo0A with intragenic suppressors in the effector domain Fems Microbiology Letters. 185: 123-128. PMID 10754235 DOI: 10.1111/J.1574-6968.2000.Tb09049.X	0.264
2003	Dutta S, Lewis RJ. Crystallization and preliminary crystallographic analysis of the kinase-recruitment domain of the PP2C-type phosphatase RsbU. Acta Crystallographica Section D-Biological Crystallography. 59: 191-193. PMID 12499568 DOI: 10.1107/S0907444902020723	0.264
2017	Deuis JR, Dekan Z, Wingerd JS, Smith JJ, Munasinghe NR, Bhola RF, Imlach WL, Herzig V, Armstrong DA, Rosengren KJ, Bosmans F, Waxman SG, Dib-Hajj SD, Escoubas P, Minett MS, ... ... Lewis RJ, et al. Corrigendum: Pharmacological characterisation of the highly NaV1.7 selective spider venom peptide Pn3a. Scientific Reports. 7: 46816. PMID 28548111 DOI: 10.1038/Srep46816	0.264
1995	Holmes MJ, Lewis RJ, Jones A, Hoy AW. Cooliatoxin, the first toxin from Coolia monotis (Dinophyceae). Natural Toxins. 3: 355-62. PMID 8581320 DOI: 10.1002/Nt.2620030506	0.264
2012	Eberhardt A, Hoyland CN, Vollmer D, Bisle S, Cleverley RM, Johnsborg O, HÃ¥varstein LS, Lewis RJ, Vollmer W. Attachment of capsular polysaccharide to the cell wall in Streptococcus pneumoniae. Microbial Drug Resistance (Larchmont, N.Y.). 18: 240-55. PMID 22432711 DOI: 10.1089/Mdr.2011.0232	0.264
1995	Lau CO, Tan CH, Khoo HE, Yuen R, Lewis RJ, Corpuz GP, Bignami GS. Lophozozymus pictor toxin: a fluorescent structural isomer of palytoxin. Toxicon : Official Journal of the International Society On Toxinology. 33: 1373-7. PMID 8599188 DOI: 10.1016/0041-0101(95)00075-W	0.264
2010	Nguyen-Huu TD, Mattei C, Wen PJ, Bourdelais AJ, Lewis RJ, Benoit E, Baden DG, Molgó J, Meunier FA. Ciguatoxin-induced catecholamine secretion in bovine chromaffin cells: Mechanism of action and reversible inhibition by brevenal Toxicon. 56: 792-796. PMID 19682481 DOI: 10.1016/J.Toxicon.2009.08.002	0.263
2018	Graf A, Lewis RJ, Fuchs S, Pagels M, Engelmann S, Riedel K, Pané-Farré J. The hidden lipoproteome of Staphylococcus aureus. International Journal of Medical Microbiology : Ijmm. PMID 29454809 DOI: 10.1016/J.Ijmm.2018.01.008	0.263
2002	Pottier I, Vernoux JP, Jones A, Lewis RJ. Analysis of toxin profiles in three different fish species causing ciguatera fish poisoning in Guadeloupe, French West Indies. Food Additives and Contaminants. 19: 1034-42. PMID 12456274 DOI: 10.1080/02652030210155378	0.263
1998	Harper A, Brannigan JA, Buck M, Hewitt L, Lewis RJ, Moore MH, Schneider B. Structure of d(TGCGCA)2 and a comparison to other DNA hexamers. Acta Crystallographica. Section D, Biological Crystallography. 54: 1273-84. PMID 10089504 DOI: 10.1107/S0907444998002807	0.263
2002	Delumeau O, Lewis RJ, Yudkin MD. Protein-Protein Interactions That Regulate the Energy Stress Activation of σB in Bacillus subtilis Journal of Bacteriology. 184: 5583-5589. PMID 12270815 DOI: 10.1128/Jb.184.20.5583-5589.2002	0.263
2016	Harris JR, Lewis RJ. The collagen type I segment long spacing (SLS) and fibrillar forms: Formation by ATP and sulphonated diazo dyes. Micron (Oxford, England : 1993). 86: 36-47. PMID 27162200 DOI: 10.1016/J.Micron.2016.04.008	0.262
2011	Tan HL, Glen EA, Topf AL, Hall DH, O'Sullivan JJ, Sneddon L, Wren C, Avery P, Lewis RJ, ten Dijke P, Arthur HM, Goodship JA, Keavney BD. 132 Non-synonymous SMAD6 mutations impaired inhibition of bmp signalling in patients with congenital cardiovascular malformation Heart. 97: A75-A75. DOI: 10.1136/Heartjnl-2011-300198.132	0.262
2012	Wang CI, Shaikh NH, Ramu S, Lewis RJ. A second extracellular site is required for norepinephrine transport by the human norepinephrine transporter. Molecular Pharmacology. 82: 898-909. PMID 22874414 DOI: 10.1124/Mol.112.080630	0.262
2005	Nielsen CK, Lewis RJ, Alewood D, Drinkwater R, Palant E, Patterson M, Yaksh TL, McCumber D, Smith MT. Anti-allodynic efficacy of the chi-conopeptide, Xen2174, in rats with neuropathic pain. Pain. 118: 112-24. PMID 16154696 DOI: 10.1016/J.Pain.2005.08.002	0.262
2020	Cooper M, Llinas A, Hansen PR, Caffrey M, Ray A, Sjodin S, Shamovsky I, Wada H, Jellesmark Jensen T, Sivars U, Hultin L, Andersson U, Lundqvist S, Gedda K, Jinton L, ... ... Lewis RJ, et al. Identification and Optimization of Pyrrolidine Derivatives as Highly Potent Ghrelin Receptor Full Agonists. Journal of Medicinal Chemistry. PMID 32787075 DOI: 10.1021/Acs.Jmedchem.0C00828	0.262
2015	Prashanth JR, Lewis RJ. An efficient transcriptome analysis pipeline to accelerate venom peptide discovery and characterisation. Toxicon : Official Journal of the International Society On Toxinology. PMID 26376071 DOI: 10.1016/J.Toxicon.2015.09.012	0.261
2002	Hamilton B, Hurbungs M, Jones A, Lewis RJ. Multiple ciguatoxins present in Indian Ocean reef fish. Toxicon : Official Journal of the International Society On Toxinology. 40: 1347-53. PMID 12220721 DOI: 10.1016/S0041-0101(02)00146-0	0.261
2015	Cleverley R, Lewis R. EzrA: a spectrin-like scaffold in the bacterial cell division machinery. Microbial Cell (Graz, Austria). 2: 59-61. PMID 28357277 DOI: 10.15698/Mic2015.02.187	0.261
2016	Yin K, Deuis JR, Lewis RJ, Vetter I. Transcriptomic and behavioural characterisation of a mouse model of burn pain identify the cholecystokinin 2 receptor as an analgesic target. Molecular Pain. 12. PMID 27573516 DOI: 10.1177/1744806916665366	0.261
2008	Baur S, Marles-Wright J, Buckenmaier S, Lewis RJ, Vollmer W. Synthesis of CDP-Activated Ribitol for Teichoic Acid Precursors in Streptococcus pneumoniae Journal of Bacteriology. 191: 1200-1210. PMID 19074383 DOI: 10.1128/Jb.01120-08	0.261
2016	Lewis RJ. The GpsB files: The truth is out there. Molecular Microbiology. PMID 28010044 DOI: 10.1111/Mmi.13612	0.261
2005	Tsai VW, Scott HL, Lewis RJ, Dodd PR. The role of group I metabotropic glutamate receptors in neuronal excitotoxicity in Alzheimer's disease. Neurotoxicity Research. 7: 125-41. PMID 15639804 DOI: 10.1007/Bf03033782	0.26
2014	Müller M, Reiß S, Schlüter R, Mäder U, Beyer A, Reiß W, Marles-Wright J, Lewis RJ, Pförtner H, Völker U, Riedel K, Hecker M, Engelmann S, Pané-Farré J. Deletion of membrane-associated Asp23 leads to upregulation of cell wall stress genes in Staphylococcus aureus. Molecular Microbiology. 93: 1259-68. PMID 25074408 DOI: 10.1111/Mmi.12733	0.26
2003	Ladds JC, Muchová K, Blaškovič D, Lewis RJ, Brannigan JA, Wilkinson AJ, Barák I. The response regulator Spo0A from Bacillus subtilis is efficiently phosphorylated in Escherichia coli Fems Microbiology Letters. 223: 153-157. PMID 12829280 DOI: 10.1016/S0378-1097(03)00321-5	0.26
2018	Kampf J, Gerwig J, Kruse K, Cleverley R, Dormeyer M, Grünberger A, Kohlheyer D, Commichau FM, Lewis RJ, Stülke J. Selective Pressure for Biofilm Formation in Bacillus subtilis: Differential Effect of Mutations in the Master Regulator SinR on Bistability. Mbio. 9. PMID 30181249 DOI: 10.1128/Mbio.01464-18	0.26
2011	Marles-Wright J, Lewis RJ. The structure of a D-lyxose isomerase from the σB regulon of Bacillus subtilis. Proteins. 79: 2015-9. PMID 21520290 DOI: 10.1002/Prot.23028	0.259
2007	Guile SD, Bantick JR, Cooper ME, Donald DK, Eyssade C, Ingall AH, Lewis RJ, Martin BP, Mohammed RT, Potter TJ, Reynolds RH, St-Gallay SA, Wright AD. Optimization of monocarboxylate transporter 1 blockers through analysis and modulation of atropisomer interconversion properties. Journal of Medicinal Chemistry. 50: 254-63. PMID 17228867 DOI: 10.1021/Jm060995H	0.259
2018	Cardoso FC, Hasan M, Zhao T, Lewis RJ. Toxins in pain. Current Opinion in Supportive and Palliative Care. PMID 29438128 DOI: 10.1097/Spc.0000000000000335	0.259
2019	Booth S, Lewis RJ. Structural basis for the co-ordination of cell division with the synthesis of the bacterial cell envelope. Protein Science : a Publication of the Protein Society. PMID 31495975 DOI: 10.1002/Pro.3722	0.259
2020	Scheib H, Nekaris KA, Rode-Margono J, Ragnarsson L, Baumann K, Dobson JS, Wirdateti W, Nouwens A, Nijman V, Martelli P, Ma R, Lewis RJ, Kwok HF, Fry BG. The Toxicological Intersection between Allergen and Toxin: A Structural Comparison of the Cat Dander Allergenic Protein Fel d1 and the Slow Loris Brachial Gland Secretion Protein. Toxins. 12. PMID 32012831 DOI: 10.3390/Toxins12020086	0.258
1994	Rowlands D, Logan D, Abu-Ghazaleh R, Blakemore W, Curry S, Jackson T, King A, Lea S, Lewis R, Newman J. The structure of an immunodominant loop on foot and mouth disease virus, serotype O1, determined under reducing conditions. Archives of Virology. Supplementum. 9: 51-8. PMID 8032279 DOI: 10.1007/978-3-7091-9326-6_6	0.257
1988	Lewis RJ. Negative inotropic and arrhythmic effects of high doses of ciguatoxin on guinea-pig atria and papillary muscles Toxicon. 26: 639-649. PMID 2459809 DOI: 10.1016/0041-0101(88)90246-2	0.257
1998	Lewis RJ. Structure of Caribbean ciguatoxin isolated from Caranx latus Journal of the American Chemical Society. 120: 5914-5920. DOI: 10.1021/Ja980389E	0.257
2018	Larsson ME, Harwood TD, Lewis RJ, S. W. A. H, Doblin MA. Toxicological characterization ofFukuyoa paulensis(Dinophyceae) from temperate Australia Phycological Research. 67: 65-71. DOI: 10.1111/Pre.12349	0.257
2011	Vetter I, Davis JL, Rash LD, Anangi R, Mobli M, Alewood PF, Lewis RJ, King GF. Venomics: A new paradigm for natural products-based drug discovery Amino Acids. 40: 15-28. PMID 20177945 DOI: 10.1007/S00726-010-0516-4	0.256
2020	Fernandez-Rojo MA, Brust A, Potriquet J, Daley J, Ragnarsson L, Andersson A, Mukhopadhyay P, Wilhelm P, Chin Y, Smallwood T, Clark R, King G, Ramm G, Waddell N, Lewis R, et al. The antiproliferative profile of a linear octopus-derived peptide in melanoma of BRAF-mutation. Toxicon : Official Journal of the International Society On Toxinology. 177: S2. PMID 32634945 DOI: 10.1016/J.Toxicon.2019.10.014	0.256
1994	Lewis RJ, Singh OM, Smith CV, Maxwell A, Skarzynski T, Wonacott AJ, Wigley DB. Crystallization of inhibitor complexes of an N-terminal 24 kDa fragment of the DNA gyrase B protein. Journal of Molecular Biology. 241: 128-30. PMID 8051702 DOI: 10.1006/Jmbi.1994.1480	0.256
2003	Chen CC, Lewis RJ, Harris R, Yudkin MD, Delumeau O. A supramolecular complex in the environmental stress signalling pathway of Bacillus subtilis. Molecular Microbiology. 49: 1657-69. PMID 12950928 DOI: 10.1046/J.1365-2958.2003.03663.X	0.256
2014	Gori A, Wang CA, Harvey PJ, Rosengren KJ, Bhola RF, Gelmi ML, Longhi R, Christie MJ, Lewis RJ, Alewood PF, Brust A. Stabilisierung eines cysteinreichen Kegelschneckentoxins, MrIA, in Form eines 1,2,3-Triazol-Disulfidbrückenmimetikums Angewandte Chemie. 127: 1378-1381. DOI: 10.1002/Ange.201409678	0.256
2017	Rozanska A, Richter-Dennerlein R, Rorbach J, Gao F, Lewis RJ, Chrzanowska-Lightowlers ZM, Lightowlers RN. The human RNA-binding protein RBFA promotes the maturation of the mitochondrial ribosome. The Biochemical Journal. PMID 28512204 DOI: 10.1042/Bcj20170256	0.255
2003	Marshall J, Nichols PD, Hamilton B, Lewis RJ, Hallegraeff GM. Ichthyotoxicity of Chattonella marina (Raphidophyceae) to damselfish (Acanthochromis polycanthus): the synergistic role of reactive oxygen species and free fatty acids Harmful Algae. 2: 273-281. DOI: 10.1016/S1568-9883(03)00046-5	0.254
2011	Kawai Y, Marles-Wright J, Cleverley RM, Emmins R, Ishikawa S, Kuwano M, Heinz N, Bui NK, Hoyland CN, Ogasawara N, Lewis RJ, Vollmer W, Daniel RA, Errington J. A widespread family of bacterial cell wall assembly proteins. The Embo Journal. 30: 4931-41. PMID 21964069 DOI: 10.1038/Emboj.2011.358	0.254
2014	Manger R, Woodle D, Berger A, Dickey RW, Jester E, Yasumoto T, Lewis R, Hawryluk T, Hungerford J. Flow cytometric-membrane potential detection of sodium channel active marine toxins: application to ciguatoxins in fish muscle and feasibility of automating saxitoxin detection. Journal of Aoac International. 97: 299-306. PMID 24830140 DOI: 10.5740/Jaoacint.Sgemanger	0.253
2011	Cuskin F, Solovyova AS, Lewis RJ, Race PR. Crystallization and preliminary X-ray analysis of the bacillaene synthase trans-acting acyltransferase PksC. Acta Crystallographica. Section F, Structural Biology and Crystallization Communications. 67: 464-6. PMID 21505242 DOI: 10.1107/S1744309111003484	0.252
2009	Underwood S, Guan S, Vijayasubhash V, Baines SD, Graham L, Lewis RJ, Wilcox MH, Stephenson K. Characterization of the sporulation initiation pathway of Clostridium difficile and its role in toxin production. Journal of Bacteriology. 191: 7296-305. PMID 19783633 DOI: 10.1128/Jb.00882-09	0.252
2006	Lewis RJ. Ciguatera: Australian perspectives on a global problem Toxicon. 48: 799-809. PMID 16930661 DOI: 10.1016/J.Toxicon.2006.07.019	0.251
2018	Larsson ME, Laczka OF, Harwood DT, Lewis RJ, Himaya SWA, Murray SA, Doblin MA. Toxicology of Gambierdiscus spp. (Dinophyceae) from Tropical and Temperate Australian Waters. Marine Drugs. 16. PMID 29301247 DOI: 10.3390/Md16010007	0.251
2012	Pitts AC, Tuck LR, Faulds-Pain A, Lewis RJ, Marles-Wright J. Structural insight into the Clostridium difficile ethanolamine utilisation microcompartment. Plos One. 7: e48360. PMID 23144756 DOI: 10.1371/Journal.Pone.0048360	0.25
1992	Magnus P, Carter P, Elliott J, Lewis R, Harling J, Pitterna T, Bauta WE, Fortt S. Synthetic and mechanistic studies on the antitumor antibiotics esperamicin A1 and calicheamicin .gamma.1: synthesis of 2-ketobicyclo[7.3.1.]enediyne and 13-ketocyclo[7.3.1]enediyne cores mediated by .eta.2]dicobalt hexacarbonyl alkyne complexes. Cycloaromatization rate studies Journal of the American Chemical Society. 114: 2544-2559. DOI: 10.1021/Ja00033A031	0.25
2010	Marles-Wright J, Lewis RJ. The stressosome: molecular architecture of a signalling hub. Biochemical Society Transactions. 38: 928-33. PMID 20658979 DOI: 10.1042/Bst0380928	0.25
2014	Lloyd LS, Asghar A, Burns MJ, Charlton A, Coombes S, Cowley MJ, Dear GJ, Duckett SB, Genov GR, Green GGR, Highton LAR, Hooper AJJ, Khan M, Khazal IG, Lewis RJ, et al. Hyperpolarisation through reversible interactions with parahydrogen Catalysis Science and Technology. 4: 3544-3554. DOI: 10.1039/C4Cy00464G	0.25
2012	Harris JR, Soliakov A, Lewis RJ, Depoix F, Watkinson A, Lakey JH. Alhydrogel® adjuvant, ultrasonic dispersion and protein binding: a TEM and analytical study. Micron (Oxford, England : 1993). 43: 192-200. PMID 21831642 DOI: 10.1016/J.Micron.2011.07.012	0.249
2014	Prashanth JR, Brust A, Jin A, Alewood PF, Dutertre S, Lewis RJ. Erratum: Cone snail venomics: From novel biology to novel therapeutics (Future Medicinal Chemistry (2014) 6:15 (1659-1675)) Future Medicinal Chemistry. 6. DOI: 10.4155/Fmc.14.159	0.249
2008	Quin M, Newman J, Firbank S, Lewis RJ, Marles-Wright J. Crystallization and preliminary X-ray analysis of RsbS from Moorella thermoacetica at 2.5 Å resolution Acta Crystallographica Section F-Structural Biology and Crystallization Communications. 64: 196-199. PMID 18323607 DOI: 10.1107/S1744309108003849	0.249
1996	Lewis RJ, Brannigan JA, Smith I, Wilkinson AJ. Crystallisation of the Bacillus subtilis sporulation inhibitor SinR, complexed with its antagonist, SinI. Febs Letters. 378: 98-100. PMID 8549812 DOI: 10.1016/0014-5793(95)01432-2	0.249
1998	Cervin MA, Lewis RJ, Brannigan JA, Spiegelman GB. The Bacillus subtilis regulator SinR inhibits spollG promoter transcription in vitro without displacing RNA polymerase Nucleic Acids Research. 26: 3806-3812. PMID 9685500 DOI: 10.1093/Nar/26.16.3806	0.249
2019	Cardoso FC, King GF, Lewis RJ. Discovery of novel CaV and NaV modulators in spider venoms and applications in the development of drugs to treat chronic pain. Toxicon. 158. DOI: 10.1016/J.Toxicon.2018.10.021	0.249
2003	Martin IJ, Lewis RJ, Bonnert RV, Cage P, Moody GC. NMR identification of an S-linked glucuronide of a triazole thione formed in vitro. Drug Metabolism and Disposition: the Biological Fate of Chemicals. 31: 694-6. PMID 12756198 DOI: 10.1124/Dmd.31.6.694	0.248
2015	Peterson EA, Teffera Y, Albrecht BK, Bauer D, Bellon SF, Boezio A, Boezio C, Broome MA, Choquette D, Copeland KW, Dussault I, Lewis R, Lin MH, Lohman J, Liu J, et al. Correction to Discovery of Potent and Selective 8-Fluorotriazolopyridine c-Met Inhibitors. Journal of Medicinal Chemistry. 58: 4087. PMID 25901648 DOI: 10.1021/Acs.Jmedchem.5B00591	0.248
2003	Bryan-Lluka LJ, Bönisch H, Lewis RJ. chi-Conopeptide MrIA partially overlaps desipramine and cocaine binding sites on the human norepinephrine transporter. The Journal of Biological Chemistry. 278: 40324-9. PMID 12837768 DOI: 10.1074/Jbc.M213101200	0.248
2012	Tan HL, Glen E, Töpf A, Hall D, O'Sullivan JJ, Sneddon L, Wren C, Avery P, Lewis RJ, ten Dijke P, Arthur HM, Goodship JA, Keavney BD. Nonsynonymous variants in the SMAD6 gene predispose to congenital cardiovascular malformation. Human Mutation. 33: 720-7. PMID 22275001 DOI: 10.1002/Humu.22030	0.248
2010	Muttenthaler MM, Araujo ADd, Andersson A, Vetter I, Gruber C, Ramos YG, Feytens D, Bergmayr C, Freissmuth M, Lewis R, Alewood P. Oxytocin agonist design - A selenocysteine mimetic reveals a functional selectivity switch for the human oxytocin receptor Journal of Peptide Science. 16: 161-161. DOI: 10.1002/Psc.1303	0.248
2011	Lehnik-Habrink M, Newman J, Rothe FM, Solovyova AS, Rodrigues C, Herzberg C, Commichau FM, Lewis RJ, Stülke J. RNase Y in Bacillus subtilis: a Natively disordered protein that is the functional equivalent of RNase E from Escherichia coli. Journal of Bacteriology. 193: 5431-41. PMID 21803996 DOI: 10.1128/Jb.05500-11	0.248
2012	Newman JA, Hewitt L, Rodrigues C, Solovyova AS, Harwood CR, Lewis RJ. Dissection of the network of interactions that links RNA processing with glycolysis in the Bacillus subtilis degradosome. Journal of Molecular Biology. 416: 121-36. PMID 22198292 DOI: 10.1016/J.Jmb.2011.12.024	0.248
1989	Camilleri P, Barker MD, Kerr MW, Whitehouse MK, Bowyer JR, Lewis RJ. Structure Activity Studies On the Inhibition of Photosystem-Ii Electron-Transport by Phenylbiurets Journal of Agricultural and Food Chemistry. 37: 1509-1513. DOI: 10.1021/Jf00090A013	0.248
1993	Lewis RJ, Hoy AW, Sellin M. Ciguatera and mannitol: in vivo and in vitro assessment in mice. Toxicon : Official Journal of the International Society On Toxinology. 31: 1039-50. PMID 8212042 DOI: 10.1016/0041-0101(93)90262-H	0.247
2017	Morgan M, Deuis JR, Woodruff TM, Lewis RJ, Vetter I. Role of complement anaphylatoxin receptors in a mouse model of acute burn-induced pain. Molecular Immunology. 94: 68-74. PMID 29274925 DOI: 10.1016/J.Molimm.2017.12.016	0.247
2012	Lloyd LS, Adams RW, Bernstein M, Coombes S, Duckett SB, Green GG, Lewis RJ, Mewis RE, Sleigh CJ. Utilization of SABRE-derived hyperpolarization to detect low-concentration analytes via 1D and 2D NMR methods. Journal of the American Chemical Society. 134: 12904-7. PMID 22812599 DOI: 10.1021/Ja3051052	0.247
2006	Martin IJ, Lewis RJ, Bernstein MA, Beattie IG, Martin CA, Riley RJ, Springthorpe B. Which hydroxy? Evidence for species differences in the regioselectivity of glucuronidation in rat, dog, and human in vitro systems and dog in vivo. Drug Metabolism and Disposition: the Biological Fate of Chemicals. 34: 1502-7. PMID 16763016 DOI: 10.1124/Dmd.106.009282	0.247
2012	Valliere Cd, Vidal S, Vetter I, Inserra M, Lewis RJ, Cooper MA, Bentz S, Wang Y, Ludwig M, Kullak-Ublick GA, Seuwen K, Wagner CA, Rogler G, Eloranta JJ. Tu1887 The Gene Encoding the G Protein-Coupled Receptor 68 (GPR68/ OGR1) is Regulated by TNF, Hypoxia, and Low pH in Human Monocytic Cells Gastroenterology. 142. DOI: 10.1016/S0016-5085(12)63374-5	0.247
1997	Lewis RJ, Jones A. Characterization of ciguatoxins and ciguatoxin congeners present in ciguateric fish by gradient reverse-phase high-performance liquid chromatography/mass spectrometry. Toxicon : Official Journal of the International Society On Toxinology. 35: 159-68. PMID 9080572 DOI: 10.1016/S0041-0101(96)00132-8	0.247
2018	Conroy S, Kindon ND, Glenn J, Stoddart LA, Lewis RJ, Hill SJ, Kellam B, Stocks MJ. Correction to Synthesis and Evaluation of the First Fluorescent Antagonists of the Human P2Y Receptor Based on AR-C118925. Journal of Medicinal Chemistry. PMID 29688707 DOI: 10.1021/Acs.Jmedchem.8B00606	0.246
2013	Liebal UW, Millat T, Marles-Wright J, Lewis RJ, Wolkenhauer O. Simulations of stressosome activation emphasize allosteric interactions between RsbR and RsbT. Bmc Systems Biology. 7: 3. PMID 23320651 DOI: 10.1186/1752-0509-7-3	0.246
1983	Lewis RJ, Endean R. Occurrence of a ciguatoxin-like substance in the Spanish mackerel (Scomberomorus commersoni) Toxicon. 21: 19-24. PMID 6845383 DOI: 10.1016/0041-0101(83)90045-4	0.245
2011	Mete A, Andrews G, Bernstein M, Connolly S, Hartopp P, Jackson CG, Lewis R, Martin I, Murray D, Riley R, Robinson DH, Smith GM, Wells E, Withnall WJ. Design of novel and potent cPLA2α inhibitors containing an α-methyl-2-ketothiazole as a metabolically stable serine trap. Bioorganic & Medicinal Chemistry Letters. 21: 3128-33. PMID 21450464 DOI: 10.1016/J.Bmcl.2011.03.005	0.245
2019	Ward RA, Anderton MJ, Bethel PA, Breed J, Cook C, Davies E, Dobson A, Dong Z, Fairley G, Farrington P, Feron LJ, Flemington V, Gibbons FD, Graham MA, Greenwood RDR, ... ... Lewis RJ, et al. Discovery of a potent and selective oral inhibitor of ERK1/2 (AZD0364) that is efficacious in both monotherapy and combination therapy in models of non-small cell lung cancer (NSCLC). Journal of Medicinal Chemistry. PMID 31710489 DOI: 10.1021/Acs.Jmedchem.9B01295	0.244
1986	Gillespie NC, Lewis RJ, Pearn JH, Bourke ATC, Holmes MJ, Bourke JB, Shields WJ. Ciguatera in Australia. Occurrence, clinical features, pathophysiology and management. The Medical Journal of Australia. 145: 584-590. DOI: 10.5694/J.1326-5377.1986.Tb139504.X	0.244
1992	Magnus P, Lewis R, Bennett F. Synthetic and mechanistic studies on the antitumor antibiotics esperamicin A1 and calicheamicin .gamma.1. Oxidative functionalization of the 13-ketobicyclo[7.3.1]tridecenediyne core structure: construction of the allylic trisulfide trigger Journal of the American Chemical Society. 114: 2560-2567. DOI: 10.1021/Ja00033A032	0.244
1992	Lewis RJ, Sellin M. Multiple ciguatoxins in the flesh of fish. Toxicon. 30: 915-919. PMID 1523683 DOI: 10.1016/0041-0101(92)90390-Q	0.244
2001	Lewis RJ, Brannigan JA, Barák I, Wilkinson AJ. Lessons and questions from the structure of the Spo0A activation domain: Response Trends in Microbiology. 9: 150-151. DOI: 10.1016/S0966-842X(01)01982-5	0.244
2014	Wilson WC, Hornig-Do HT, Bruni F, Chang JH, Jourdain AA, Martinou JC, Falkenberg M, Spåhr H, Larsson NG, Lewis RJ, Hewitt L, Baslé A, Cross HE, Tong L, Lebel RR, et al. A human mitochondrial poly(A) polymerase mutation reveals the complexities of post-transcriptional mitochondrial gene expression. Human Molecular Genetics. 23: 6345-55. PMID 25008111 DOI: 10.1093/Hmg/Ddu352	0.244
2017	Chen Y, Aurell CJ, Pettersen A, Lewis RJ, Hayes MA, Lepistö M, Jonson AC, Leek H, Thunberg L. Saccharin Aza Bioisosteres-Synthesis and Preclinical Property Comparisons. Acs Medicinal Chemistry Letters. 8: 672-677. PMID 28626531 DOI: 10.1021/Acsmedchemlett.7B00137	0.243
1996	Lewis RJ, Tsai FT, Wigley DB. Molecular mechanisms of drug inhibition of DNA gyrase. Bioessays : News and Reviews in Molecular, Cellular and Developmental Biology. 18: 661-71. PMID 8760340 DOI: 10.1002/Bies.950180810	0.243
1981	Cameron AM, Surridge J, Stablum W, Lewis RJ. A crinotoxin from the skin tubercle glands of a stonefish (Synanceia trachynis) Toxicon. 19: 159-170. PMID 7013156 DOI: 10.1016/0041-0101(81)90128-8	0.243
2012	Muttenthaler M, Dawson PE, Gruber CW, Bergmayr C, Freissmuth M, Andersson A, Vetter I, Dutertre S, Lewis RJ, Alewood PF. Novel sources for potent and selective GPCR modulators Journal of Peptide Science. 18. DOI: 10.1002/Psc.2447	0.242
2011	Potter T, Lewis R, Luker T, Bonnert R, Bernstein MA, Birkinshaw TN, Thom S, Wenlock M, Paine S. In silico prediction of acyl glucuronide reactivity. Journal of Computer-Aided Molecular Design. 25: 997-1005. PMID 22042375 DOI: 10.1007/S10822-011-9479-0	0.242
2015	Kryshtafovych A, Moult J, Baslé A, Burgin A, Craig TK, Edwards RA, Fass D, Hartmann MD, Korycinski M, Lewis RJ, Lorimer D, Lupas AN, Newman J, Peat TS, Piepenbrink KH, et al. Some of the most interesting CASP11 targets through the eyes of their authors. Proteins. PMID 26473983 DOI: 10.1002/Prot.24942	0.242
1996	Euerby MR, Graham JA, Johnson CM, Lewis RJ, Wallace DB. The S-oxidative degradation of a novel corticosteroid tipredane (INN) Part III. Detailed investigations into the disulphoxidation of tipredane. Journal of Pharmaceutical and Biomedical Analysis. 15: 299-313. PMID 8951690 DOI: 10.1016/S0731-7085(96)01860-2	0.242
2014	Deuis JR, Lim YL, Rodrigues de Sousa S, Lewis RJ, Alewood PF, Cabot PJ, Vetter I. Analgesic effects of clinically used compounds in novel mouse models of polyneuropathy induced by oxaliplatin and cisplatin. Neuro-Oncology. 16: 1324-32. PMID 24714523 DOI: 10.1093/Neuonc/Nou048	0.241
2018	Gu C, Artelsmair M, Elmore CS, Lewis RJ, Davis P, Hall JE, Dembofsky BT, Christoph G, Smith MA, Chapdelaine M, Sunzel M. Late-occurring and long-circulating metabolites of GABAAα2,3 receptor modulator AZD7325 involving metabolic cyclization and aromatization: relevance to MIST analysis and application for patient compliance. Drug Metabolism and Disposition: the Biological Fate of Chemicals. PMID 29311137 DOI: 10.1124/Dmd.117.078873	0.241
2002	Pottier I, Vernoux JP, Jones A, Lewis RJ. Characterisation of multiple Caribbean ciguatoxins and congeners in individual specimens of horse-eye jack (Caranx latus) by high-performance liquid chromatography/mass spectrometry. Toxicon : Official Journal of the International Society On Toxinology. 40: 929-39. PMID 12076647 DOI: 10.1016/S0041-0101(02)00088-0	0.241
2013	Skinner MP, Lewis RJ, Morton S. Ecology of the ciguatera causing dinoflagellates from the Northern Great Barrier Reef: changes in community distribution and coastal eutrophication. Marine Pollution Bulletin. 77: 210-9. PMID 24210944 DOI: 10.1016/J.Marpolbul.2013.10.003	0.24
2016	Peters K, Kannan S, Rao VA, Biboy J, Vollmer D, Erickson SW, Lewis RJ, Young KD, Vollmer W. The Redundancy of Peptidoglycan Carboxypeptidases Ensures Robust Cell Shape Maintenance in Escherichia coli. Mbio. 7. PMID 27329754 DOI: 10.1128/Mbio.00819-16	0.24
1999	Rao KN, Hegde SS, Lewis RJ, Suresh CG. Crystallization and preliminary x-ray diffraction studies of a Bowman-Birk inhibitor from Vigna unguiculata seeds. Acta Crystallographica. Section D, Biological Crystallography. 55: 1920-2. PMID 10531495 DOI: 10.1107/S0907444999010021	0.239
2008	Marles-Wright J, Grant T, Delumeau O, van Duinen G, Firbank SJ, Lewis PJ, Murray JW, Newman JA, Quin MB, Race PR, Rohou A, Tichelaar W, van Heel M, Lewis RJ. Molecular architecture of the "stressosome," a signal integration and transduction hub. Science (New York, N.Y.). 322: 92-6. PMID 18832644 DOI: 10.1126/Science.1159572	0.239
1991	Holmes MJ, Lewis RJ, Poli MA, Gillespie NC. Strain dependent production of ciguatoxin precursors (gambiertoxins) by Gambierdiscus toxicus (Dinophyceae) in culture. Toxicon. 29: 761-775. PMID 1926177 DOI: 10.1016/0041-0101(91)90068-3	0.238
1991	Lewis RJ, Camilleri P, Kirby AJ, Marby CA, Slawin AA, Williams DJ. Structure–activity studies on amides inhibiting photosystem II Journal of the Chemical Society-Perkin Transactions 1. 1625-1630. DOI: 10.1039/P29910001625	0.238
2005	Garrec RB, Benoit E, Sauviat M, Lewis RJ, Molgó J, Laurent D. Ability of some plant extracts, traditionally used to treat ciguatera fish poisoning, to prevent the in vitro neurotoxicity produced by sodium channel activators. Toxicon. 46: 625-634. PMID 16165180 DOI: 10.1016/J.Toxicon.2005.07.002	0.237
1999	Muchová K, Lewis RJ, Brannigan JA, Offen WA, Brown DP, Barák I, Youngman P, Wilkinson AJ. Crystallization of the regulatory and effector domains of the key sporulation response regulator Spo0A. Acta Crystallographica. Section D, Biological Crystallography. 55: 671-6. PMID 10089466 DOI: 10.1107/S0907444998012682	0.237
2010	Lewis RJ, Poli M. Editorial: Toxins in seafood Toxicon. 56: 107. PMID 20510727 DOI: 10.1016/J.Toxicon.2010.05.002	0.237
1982	Lewis RJ, Kaback E, Krulwich TA. Pleiotropic Properties of Mutations to Non-alkalophily in Bacillus alcalophilus Microbiology. 128: 427-430. DOI: 10.1099/00221287-128-2-427	0.237
2021	Dongol Y, Choi PM, Wilson DT, Daly NL, Cardoso FC, Lewis RJ. Voltage-Gated Sodium Channel Modulation by a New Spider Toxin Ssp1a Isolated From an Australian Theraphosid. Frontiers in Pharmacology. 12: 795455. PMID 35002728 DOI: 10.3389/fphar.2021.795455	0.237
1998	Ducros VM‐, Brannigan JA, Lewis RJ, Wilkinson AJ. Bacillus subtilis regulatory protein GerE. Acta Crystallographica Section D-Biological Crystallography. 54: 1453-1455. PMID 10089536 DOI: 10.1107/S0907444998004892	0.236
2005	Stephenson K, Lewis RJ. Molecular insights into the initiation of sporulation in Gram-positive bacteria: new technologies for an old phenomenon Fems Microbiology Reviews. 29: 281-301. DOI: 10.1016/J.Fmrre.2004.10.003	0.236
1984	Lewis RJ, Endean R. Ciguatoxin from the flesh and viscera of the barracuda, Sphyraena jello Toxicon. 22: 805-810. PMID 6523508 DOI: 10.1016/0041-0101(84)90163-6	0.235
1999	Lewis RJ, Jones A, Vernoux JP. HPLC/tandem electrospray mass spectrometry for the determination of Sub-ppb levels of Pacific and Caribbean ciguatoxins in crude extracts of fish. Analytical Chemistry. 71: 247-50. PMID 9921131 DOI: 10.1021/Ac980598H	0.235
2008	Zhang H, Major JM, Lewis RJ, Capon RJ. Phorbasins G-K: new cytotoxic diterpenes from a southern Australian marine sponge, Phorbas sp. Organic & Biomolecular Chemistry. 6: 3811-5. PMID 18843411 DOI: 10.1039/B808866G	0.235
2010	Hamilton B, Whittle N, Shaw G, Eaglesham G, Moore MR, Lewis RJ. Human fatality associated with Pacific ciguatoxin contaminated fish. Toxicon : Official Journal of the International Society On Toxinology. 56: 668-73. PMID 19538985 DOI: 10.1016/J.Toxicon.2009.06.007	0.235
2011	Valliere Cd, Hiller C, Kellermeier S, Crucet M, Vetter I, Inserra M, Lewis RJ, Cooper MA, Vidal S, Seuwen K, Wagner CA, Fried M, Kullak-Ublick GA, Rogler G, Eloranta JJ. Expression of the G Protein-Coupled Receptor 68 is Increased by TNF-Mediated Inflammatory Signalling Gastroenterology. 140. DOI: 10.1016/S0016-5085(11)63474-4	0.234
2015	Gu C, Lewis RJ, Wells AS, Svensson PH, Hosagrahara VP, Johnsson E, Hallström G. Lipid Peroxide-Mediated Oxidative Rearrangement of the Pyrazinone Carboxamide Core of Neutrophil Elastase Inhibitor AZD9819 in Blood Plasma Samples. Drug Metabolism and Disposition: the Biological Fate of Chemicals. 43: 1441-9. PMID 26203069 DOI: 10.1124/Dmd.115.065136	0.234
2015	Yin K, Zimmermann K, Vetter I, Lewis RJ. Therapeutic opportunities for targeting cold pain pathways. Biochemical Pharmacology. 93: 125-40. PMID 25316567 DOI: 10.1016/J.Bcp.2014.09.024	0.234
2020	Slanina T, Ayub R, Toldo J, Sundell J, Rabten W, Nicaso M, Alabugin IV, Gupta AK, Fdez Galván I, Lindh R, Orthaber A, Lewis RJ, Grönberg G, Bergman J, Ottosson H. On the Impact of Excited State Antiaromaticity Relief in a Fundamental Benzene Photoreaction Leading to Substituted Bicyclo[3.1.0]hexenes. Journal of the American Chemical Society. PMID 32456426 DOI: 10.1021/Jacs.9B13769	0.233
2013	Lewis RJ, Bernstein MA, Chang HF, Chapman D, Pemberton N. Enantiomeric purity determination by NMR: Proving the purity of a single enantiomer Tetrahedron Asymmetry. 24: 866-870. DOI: 10.1016/J.Tetasy.2013.05.014	0.233
1990	Jones PG, Kirby AJ, Lewis RJ. N-(3,4-Dichlorophenyl)cyclopropanecarboxamide and N-(3,4-dichlorophenyl)acetamide Acta Crystallographica Section C Crystal Structure Communications. 46: 78-81. DOI: 10.1107/S010827018900510X	0.233
2021	Armstrong DA, Jin AH, Braga Emidio N, Lewis RJ, Alewood PF, Rosengren KJ. Chemical Synthesis and NMR Solution Structure of Conotoxin GXIA from . Marine Drugs. 19. PMID 33530397 DOI: 10.3390/md19020060	0.233
2007	Gill S, O'Neill R, Lewis RJ, Connolly BA. Interaction of the Family-B DNA Polymerase from the Archaeon Pyrococcus furiosus with Deaminated Bases Journal of Molecular Biology. 372: 855-863. PMID 17692870 DOI: 10.1016/J.Jmb.2007.07.015	0.233
1998	Lucas RE, Lewis RJ, Taylor JM. Pacific ciguatoxin-1 associated with a large common-source outbreak of ciguatera in east Arnhem Land, Australia. Natural Toxins. 5: 136-140. DOI: 10.1002/19970504Nt2	0.232
2013	Newman JA, Lewis RJ. Exploring the role of SlrR and SlrA in the SinR epigenetic switch. Communicative & Integrative Biology. 6: e25658. PMID 24563698 DOI: 10.4161/Cib.25658	0.232
2012	Jin A, Dutertre S, Kaas Q, Lewis RJ, Alewood PF. 98. Transcriptomic and Peptidomic Characterisation of the Conus marmoreus Venom: Insights on Conopeptide Diversity and Venomic Processing Toxicon. 60: 144-145. DOI: 10.1016/J.Toxicon.2012.04.099	0.232
2018	Shamovsky I, Belfield G, Lewis R, Narjes F, Ripa L, Tyrchan C, Öberg L, Sjö P. Theoretical studies of the second step of the nitric oxide synthase reaction: Electron tunneling prevents uncoupling. Journal of Inorganic Biochemistry. 181: 28-40. PMID 29407906 DOI: 10.1016/J.Jinorgbio.2018.01.009	0.231
2013	Brust A, Sunagar K, Undheim EAB, Vetter I, Yang DC, Casewell NR, Jackson TNW, Koludarov I, Alewood PF, Hodgson WC, Lewis RJ, King GF, Antunes A, Hendrikx I, Fry BG. Differential evolution and neofunctionalization of snake venom metalloprotease domains (Molecular and Cellular Proteomics 2013, 12, (651-663)) Molecular and Cellular Proteomics. 12: 1488. DOI: 10.1074/Mcp.A112.023135	0.23
2007	Duncan SJ, Lewis R, Bernstein MA, Sandor P. Selective excitation of overlapping multiplets; the application of doubly selective and chemical shift filter experiments to complex NMR spectra. Magnetic Resonance in Chemistry : Mrc. 45: 283-8. PMID 17295381 DOI: 10.1002/Mrc.1962	0.23
2014	Brust A, Gori A, Wang CA, Harvey PJ, Rosengren KJ, Gelmi ML, Longh R, Lewis RJ, Alewood PF. SELECTIVE FOLDING AND STABILIZATION OF A CYSTEINE RICH CONOTOXIN, MrIA AS A 1,2,3-TRIAZOLE-DISULFIDE BOND HYBRID Journal of Peptide Science. 20. DOI: 10.1002/Psc.2687	0.229
1994	Lewis RJ, Holmes MJ, Alewood PF, Jones A. Ionspray mass spectrometry of ciguatoxin-1, maitotoxin-2 and -3, and related marine polyether toxins. Natural Toxins. 2: 56-63. PMID 8075894 DOI: 10.1002/Nt.2620020203	0.228
2005	Lewis RJ, Bernstein MA, Duncan SJ, Sleigh CJ. A comparison of capillary-scale LC-NMR with alternative techniques: spectroscopic and practical considerations. Magnetic Resonance in Chemistry : Mrc. 43: 783-9. PMID 16049949 DOI: 10.1002/Mrc.1614	0.228
2016	L’herondelle K, Philippe R, Mignen O, Vetter I, Lewis RJ, Misery L, Garrec RL. Study of the involvement of itch mediators in the neuropeptide release induced by Pacific-Ciguatoxin-2 in a co-culture model of sensory neurons and keratinocytes Toxicon. 116: 73-73. DOI: 10.1016/J.Toxicon.2016.01.007	0.227
2013	Harris JR, Soliakov A, Lewis RJ. In vitro fibrillogenesis of collagen type I in varying ionic and pH conditions. Micron (Oxford, England : 1993). 49: 60-8. PMID 23582981 DOI: 10.1016/J.Micron.2013.03.004	0.227
2020	Kuo A, Magiera J, Rethwan N, Andersson Å, Leen Lam A, Wyse B, Meutermans W, Lewis R, Smith M. In vitro profiling of opioid ligands using the cAMP formation inhibition assay and the β-arrestin2 recruitment assay: No two ligands have the same profile. European Journal of Pharmacology. 172947. PMID 31991138 DOI: 10.1016/J.Ejphar.2020.172947	0.227
2010	Stewart I, Lewis RJ, Eaglesham GK, Graham GC, Poole S, Craig SB. Emerging tropical diseases in Australia. Part 2. Ciguatera fish poisoning. Annals of Tropical Medicine and Parasitology. 104: 557-71. PMID 21092393 DOI: 10.1179/136485910X12851868779902	0.226
2011	Harris JR, Lewis RJ, Baik C, Pokrajac L, Billington SJ, Palmer M. Cholesterol microcrystals and cochleate cylinders: attachment of pyolysin oligomers and domain 4. Journal of Structural Biology. 173: 38-45. PMID 20682347 DOI: 10.1016/J.Jsb.2010.07.010	0.226
2011	Dekan Z, Vetter I, Daly N, Lewis R, Alewood P, Craik D. alpha-conotoxin ImI cystathionine 1-3 Journal of Back and Musculoskeletal Rehabilitation. DOI: 10.13018/Bmr21007	0.226
2011	Dekan Z, Vetter I, Daly N, Lewis R, Alewood P, Craik D. alpha-conotoxin ImI cystathionine 2-4 Journal of Back and Musculoskeletal Rehabilitation. DOI: 10.13018/Bmr21006	0.226
2012	Lehnik-Habrink M, Lewis RJ, MÃ¤der U, StÃ¼lke J. RNA degradation in Bacillus subtilis: an interplay of essential endo- and exoribonucleases. Molecular Microbiology. 84: 1005-17. PMID 22568516 DOI: 10.1111/J.1365-2958.2012.08072.X	0.226
1998	Moore MR, Ng JC, Lewis RJ. Environmental poisoning: presentation and management. Therapeutic Drug Monitoring. 20: 502-9. PMID 9780126 DOI: 10.1097/00007691-199810000-00010	0.225
2013	Stanley WA, Hewitt L, Rodrigues C, Lewis RJ. Understanding proline biosynthesis inBacillus subtilis Acta Crystallographica Section A. 69. DOI: 10.1107/S0108767313097079	0.225
2012	Ragnarsson L, Anderson Wang C, Andersson Å, Fajarningsih D, Monks T, Brust A, Rosengren KJ, Lewis RJ. 136. The Allosteric Binding Site for ρ-TIA on the Extracellular Surface of the α1B- Adrenoceptor Toxicon. 60: 164. DOI: 10.1016/J.Toxicon.2012.04.137	0.224
2006	Aigbirhio FI, Alexakis E, Allen J, Baron J, Beech J, Beyer J, Bloxsidge JP, Botting NP, Brichard L, Bushby N, Cable K, Clark JC, Conway LK, Del Fiore G, Dollé F, ... ... Lewis RJ, ... ... Lewis RJ, et al. 15th International Isotope Society (UK group) Symposium Journal of Labelled Compounds and Radiopharmaceuticals. 49: 377-420. DOI: 10.1002/Jlcr.948	0.224
2001	Pottier I, Vernoux J, Lewis RJ. Ciguatera fish poisoning in the Caribbean islands and Western Atlantic. Reviews of Environmental Contamination and Toxicology. 168: 99-141. PMID 12882228 DOI: 10.1007/978-1-4613-0143-1_3	0.224
1988	Camilleri P, Kirby AJ, Lewis RJ, Sanders JKM. Stereoelectronic effects on anilide conformation Journal of the Chemical Society, Chemical Communications. 1537-1538. DOI: 10.1039/C39880001537	0.224
2008	Lewis R, Schroeder C. NMR solution structure of mu-conotoxin SIIIA Journal of Back and Musculoskeletal Rehabilitation. DOI: 10.13018/Bmr20025	0.223
2020	Bergare J, Kingston L, Guly DJ, Dolan J, Lewis RJ, Elmore CS. The synthesis of one H-2 labeled and two H-3 labeled leukotriene C4 synthase inhibitors. Journal of Labelled Compounds & Radiopharmaceuticals. PMID 32441366 DOI: 10.1002/Jlcr.3862	0.223
2012	Lewis RJ. 39. Discovery and Development of χ-Conopeptides for the Treatment of Pain Toxicon. 60: 114-115. DOI: 10.1016/J.Toxicon.2012.04.040	0.223
2020	McMahon KL, Tran HNT, Deuis JR, Lewis RJ, Vetter I, Schroeder CI. Discovery, Pharmacological Characterisation and NMR Structure of the Novel µ-Conotoxin SxIIIC, a Potent and Irreversible Na Channel Inhibitor. Biomedicines. 8. PMID 33023152 DOI: 10.3390/biomedicines8100391	0.223
2009	Yang X, Molimau S, Doherty GP, Johnston EB, Marles-Wright J, Rothnagel R, Hankamer B, Lewis RJ, Lewis PJ. The structure of bacterial RNA polymerase in complex with the essential transcription elongation factor NusA. Embo Reports. 10: 997-1002. PMID 19680289 DOI: 10.1038/Embor.2009.155	0.221
2006	Lewis RJ, Hughes RA, Alcaraz L, Thompson SP, Moody CJ. Solution structures of thiopeptide antibiotics. Chemical Communications (Cambridge, England). 4215-7. PMID 17031436 DOI: 10.1039/B609282A	0.221
2009	Lewis RJ, Yang A, Jones A. Rapid extraction combined with LC-tandem mass spectrometry (CREM-LC/MS/MS) for the determination of ciguatoxins in ciguateric fish flesh. Toxicon : Official Journal of the International Society On Toxinology. 54: 62-6. PMID 19303895 DOI: 10.1016/J.Toxicon.2009.03.013	0.22
2001	Johnson LN, Lewis RJ. Structural basis for control by phosphorylation. Chemical Reviews. 101: 2209-42. PMID 11749371 DOI: 10.1021/Cr000225S	0.219
1994	Euerby MR, Johnson CM, Lewis RJ, Nichols SC. The S-oxidative degradation of a novel corticosteroid tipredane (INN). Part II — Detailed investigations into the primary S-oxidation of tipredane using achiral oxidants Journal of Pharmaceutical and Biomedical Analysis. 12: 761-769. PMID 7918778 DOI: 10.1016/0731-7085(93)E0031-H	0.218
2019	Booth S, Norton L, Gaimster H, Basle A, Rao V, Hewitt L, Murray H, Lewis RJ. Molecular basis of self-induced genomic degradation inhibition by the sub-nanomolar interaction of Nin with NucA and NucB endonucleases Acta Crystallographica Section A. 75. DOI: 10.1107/S205327331909449X	0.218
2013	Garrec RL, Vetter I, Lewis RJ, Misery L. Ciguatoxin-Induced Release of Neuropeptides in a Sensory Neuron-Keratinocyte Coculture Model Acta Dermato-Venereologica. 93: 612-612. DOI: 10.2340/00015555-1701	0.218
1989	Pearn JH, Lewis RJ, Ruff T, Tait M, Quinn J, Murtha W, King G, Mallett A, Gillespie NC. Ciguatera and mannitol: experience with a new treatment regimen. The Medical Journal of Australia. 151: 77-80. PMID 2500582 DOI: 10.5694/J.1326-5377.1989.Tb101165.X	0.217
1993	Lewis RJ, Sellin M. Recovery of ciguatoxin from fish flesh Toxicon. 31: 1333-1336. PMID 8303728 DOI: 10.1016/0041-0101(93)90407-A	0.217
1999	Eriksson L, Guy S, Perlmutter P, Lewis R. A Short Synthesis of the A/B Ring Systems of the Pacific Ciguatoxins P-CTX-3C and Dihydroxy-P-CTX-3C. The Journal of Organic Chemistry. 64: 8396-8398. PMID 11674764 DOI: 10.1021/Jo990389C	0.216
2021	Ho TNT, Lee HS, Swaminathan S, Goodwin L, Rai N, Ushay B, Lewis RJ, Rosengren KJ, Conibear AC. Posttranslational modifications of α-conotoxins: sulfotyrosine and C-terminal amidation stabilise structures and increase acetylcholine receptor binding. Rsc Medicinal Chemistry. 12: 1574-1584. PMID 34671739 DOI: 10.1039/d1md00182e	0.216
2017	Morgan M, Deuis JR, Frøsig-Jørgensen M, Lewis RJ, Cabot PJ, Gray PD, Vetter I. Burn Pain: A Systematic and Critical Review of Epidemiology, Pathophysiology, and Treatment. Pain Medicine (Malden, Mass.). PMID 29036469 DOI: 10.1093/Pm/Pnx228	0.216
1971	Trager WF, Lewis RJ, Garland WA. Mass spectral analysis in the identification of human metabolites of warfarin. Journal of Medicinal Chemistry. 13: 1196-204. PMID 5479866 DOI: 10.1021/Jm00300A041	0.215
2012	Valliere Cd, Vidal S, Eloranta JJ, Lang S, Vetter I, Inserra M, Lewis RJ, Cooper MA, Wang Y, Ludwig M, Kullak-Ublick GA, Wagner CA, Rogler G, Seuwen K. Tu1351 Functional Consequences of G Protein-Coupled Receptor 68 (GPR68/OGR1) Overexpression in Intestinal Epithelial Cells Gastroenterology. 142. DOI: 10.1016/S0016-5085(12)63145-X	0.215
1974	Lewis RJ, Trager WF, Chan KK, Breckenridge A, Orme M, Roland M, Schary W. Warfarin. Stereochemical aspects of its metabolism and the interaction with phenylbutazone. The Journal of Clinical Investigation. 53: 1607-17. PMID 4830225 DOI: 10.1172/Jci107711	0.215
2004	Daly NL, Ekberg JA, Thomas L, Adams DJ, Lewis RJ, Craik DJ. Solution structure of conotoxin MrVIB Journal of Back and Musculoskeletal Rehabilitation. DOI: 10.13018/Bmr6135	0.215
1996	Lewis RJ, Moodie RB. Nitration of styrenes by dinitrogen pentoxide in dichloromethane Journal of the Chemical Society-Perkin Transactions 1. 1315-1320. DOI: 10.1039/P29960001315	0.214
2018	Brust A, Wang CA, Daly NL, Kennerly J, Sadeghi M, Christie MJ, Lewis RJ, Mobli M, Alewood PF. Corrigendum: Vicinal Disulfide Constrained Cyclic Peptidomimetics: a Turn Mimetic Scaffold Targeting the Norepinephrine Transporter. Angewandte Chemie (International Ed. in English). 57: 5203. PMID 29701320 DOI: 10.1002/Anie.201803138	0.212
1997	Fenner PJ, Lewis RJ, Williamson JA, Williams ML. A Queensland family with ciguatera after eating coral trout The Medical Journal of Australia. 166: 473-475. PMID 9152341 DOI: 10.5694/J.1326-5377.1997.Tb123219.X	0.212
1997	Lewis RJ, Moodie RB. The Nitration Of Styrenes By Nitric Acid In Dichloromethane Journal of the Chemical Society-Perkin Transactions 1. 563-568. DOI: 10.1039/A605782I	0.21
2011	Skinner MP, Brewer TD, Johnstone R, Fleming LE, Lewis RJ. Ciguatera fish poisoning in the Pacific Islands (1998 to 2008). Plos Neglected Tropical Diseases. 5: e1416. PMID 22180797 DOI: 10.1371/Journal.Pntd.0001416	0.21
2020	Ho TNT, Abraham N, Lewis RJ. Structure-Function of Neuronal Nicotinic Acetylcholine Receptor Inhibitors Derived From Natural Toxins. Frontiers in Neuroscience. 14: 609005. PMID 33324158 DOI: 10.3389/fnins.2020.609005	0.209
2000	Nielsen K, Adams D, Thomas L, Bond T, Alewood P, Craik D, Lewis R. w-conotoxin MVIIC from Conus magus Journal of Back and Musculoskeletal Rehabilitation. DOI: 10.13018/Bmr4500	0.208
2010	Lewis R, Noppeney U. Audiovisual synchrony improves motion discrimination via enhanced connectivity between early visual and auditory areas. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 30: 12329-39. PMID 20844129 DOI: 10.1523/Jneurosci.5745-09.2010	0.208
1990	Holmes MJ, Lewis RJ, Gillespie NC. Toxicity of Australian and French polynesian strains of Gambierdiscus toxicus (Dinophyceae) grown in culture: characterization of a new type of maitotoxin. Toxicon. 28: 1159-1172. PMID 2264067 DOI: 10.1016/0041-0101(90)90116-O	0.207
1983	Lewis RJ, Endean R. Purification of ciguatoxin-like material from Scomberomorus commersoni and its effect on the rat phrenic nerve-diaphragm Toxicon. 21: 249-252. DOI: 10.1016/0041-0101(83)90201-5	0.205
1983	Cameron AM, Wong Hoy AW, Lewis RJ. The effects of two stonefish skin toxins on guinea-pig atria Toxicon. 21: 53-56. DOI: 10.1016/0041-0101(83)90153-8	0.205
2012	Kramer C, Lewis R. QSARs, data and error in the modern age of drug discovery. Current Topics in Medicinal Chemistry. 12: 1896-902. PMID 23116469 DOI: 10.2174/156802612804547380	0.204
2015	Cisonni J, Lucey AD, King AJ, Islam SM, Lewis R, Goonewardene MS. Numerical simulation of pharyngeal airflow applied to obstructive sleep apnea: effect of the nasal cavity in anatomically accurate airway models. Medical & Biological Engineering & Computing. 53: 1129-39. PMID 26429351 DOI: 10.1007/S11517-015-1399-Z	0.203
1947	Lewis R. New Compounds. Some New Organosilicon Compounds Journal of the American Chemical Society. 69: 717-717. DOI: 10.1021/Ja01195A601	0.2
2007	Jones JR, Lockley WJS, Lewis RJ, Wilkinson DJ. Origin of the large isotope-induced shift in the 1H-NMR of ortho-2H-labelled anilides† Journal of Labelled Compounds and Radiopharmaceuticals. 50: 535-536. DOI: 10.1002/Jlcr.1248	0.199
2020	Wamp S, Rutter ZJ, Rismondo J, Jennings CE, Möller L, Lewis RJ, Halbedel S. Author response: PrkA controls peptidoglycan biosynthesis through the essential phosphorylation of ReoM Elife. DOI: 10.7554/Elife.56048.Sa2	0.199
2009	Lewis RJ, Yang A, Jones A. Erratum to ‘‘Rapid extraction combined with LC-tandem mass spectrometry (CREM-LC/MS/MS) for the determination of ciguatoxins in ciguateric fish flesh’’ [Toxicon 54 (2009) 62–66] Toxicon. 54: 897. DOI: 10.1016/J.Toxicon.2009.06.025	0.197
2012	Tranberg CE, Yang A, Vetter I, McArthur JR, Baell JB, Lewis RJ, Tuck KL, Duggan PJ. Ï‰-Conotoxin GVIA mimetics that bind and inhibit neuronal Ca(v)2.2 ion channels. Marine Drugs. 10: 2349-68. PMID 23170089 DOI: 10.3390/Md10102349	0.195
1999	Hamilton B, Lewis RJ, Chiswell B, Moore M, Jones A. Development of analytical detection methodologies of ciguatoxins Therapeutic Drug Monitoring. 21: 484. DOI: 10.1097/00007691-199908000-00234	0.194
2015	L’herondelle K, Philippe R, Mignen O, Vetter I, Lewis RJ, Misery L, Garrec RL. La ciguatéra : l’étude du prurit sous un nouvel angle Annales De Dermatologie Et De Venereologie. 142. DOI: 10.1016/J.Annder.2015.10.028	0.193
1971	TRAGER WF, LEWIS RJ, GARLAND WA. ChemInform Abstract: MASSENSPEKTROSKOPISCHE ANALYSE DER METABOLITEN DES WARFARINS IM MENSCHLICHEN ORGANISMUS Chemischer Informationsdienst. Organische Chemie. 2: no-no. DOI: 10.1002/Chin.197111090	0.191
2021	Cardoso FC, Schmit M, Kuiper MJ, Lewis RJ, Tuck KL, Duggan PJ. Inhibition of N-type calcium ion channels by tricyclic antidepressants - experimental and theoretical justification for their use for neuropathic pain. Rsc Medicinal Chemistry. 13: 183-195. PMID 35308021 DOI: 10.1039/d1md00331c	0.19
2024	Narjes F, Edfeldt F, Petersen J, Öster L, Hamblet C, Bird J, Bold P, Rae R, Bäck E, Stomilovic S, Zlatoidsky P, Svensson T, Hidestål L, Kunalingam L, Shamovsky I, ... ... Lewis RJ, et al. Discovery and Characterization of a Bicyclic Peptide (Bicycle) Binder to Thymic Stromal Lymphopoietin. Journal of Medicinal Chemistry. PMID 38284169 DOI: 10.1021/acs.jmedchem.3c02163	0.189
2021	Ho TNT, Abraham N, Lewis RJ. Rigidity of loop 1 contributes to equipotency of globular and ribbon isomers of α-conotoxin AusIA. Scientific Reports. 11: 21928. PMID 34753970 DOI: 10.1038/s41598-021-01277-4	0.189
2022	Cardoso FC, Pineda SS, Herzig V, Sunagar K, Shaikh NY, Jin AH, King GF, Alewood PF, Lewis RJ, Dutertre S. The Deadly Toxin Arsenal of the Tree-Dwelling Australian Funnel-Web Spiders. International Journal of Molecular Sciences. 23. PMID 36361863 DOI: 10.3390/ijms232113077	0.188
2020	Dutt M, Giacomotto J, Ragnarsson L, Andersson A, Brust A, Deakan Z, Alewood PF, Lewis RJ. Re-evaluating the nirvana cabal deployed by piscivorous cone snails. Toxicon : Official Journal of the International Society On Toxinology. 177: S9-S10. PMID 32635128 DOI: 10.1016/J.Toxicon.2019.10.044	0.187
2022	Ho TNT, Abraham N, Lewis RJ. Synthesis of full-length homodimer αD-VxXXB that targets human α7 nicotinic acetylcholine receptors. Rsc Medicinal Chemistry. 13: 1410-1419. PMID 36439982 DOI: 10.1039/d2md00188h	0.182
1983	Endean R, Lewis R, Gyr P, Williamson J. Toxic material from the crab Atergatis floridus Toxicon. 21: 111-113. DOI: 10.1016/0041-0101(83)90167-8	0.182
2021	Hasan MM, Ragnarsson L, Cardoso FC, Lewis RJ. Transfection methods for high-throughput cellular assays of voltage-gated calcium and sodium channels involved in pain. Plos One. 16: e0243645. PMID 33667217 DOI: 10.1371/journal.pone.0243645	0.181
2022	Prashanth JR, Dutertre S, Rai SK, Lewis RJ. Venomics Reveals a Non-Compartmentalised Venom Gland in the Early Diverged Vermivorous . Toxins. 14. PMID 35324723 DOI: 10.3390/toxins14030226	0.179
2023	Muratspahić E, White AM, Ciotu CI, Hochrainer N, Tomašević N, Koehbach J, Lewis RJ, Spetea M, Fischer MJM, Craik DJ, Gruber CW. Development of a Selective Peptide κ-Opioid Receptor Antagonist by Late-Stage Functionalization with Cysteine Staples. Journal of Medicinal Chemistry. PMID 37632447 DOI: 10.1021/acs.jmedchem.3c00426	0.176
2021	Pierre O, Fouchard M, Le Goux N, Buscaglia P, Leschiera R, Lewis RJ, Mignen O, Fluhr JW, Misery L, Le Garrec R. Pacific-Ciguatoxin-2 and Brevetoxin-1 Induce the Sensitization of Sensory Receptors Mediating Pain and Pruritus in Sensory Neurons. Marine Drugs. 19. PMID 34356812 DOI: 10.3390/md19070387	0.176
2018	Berg A, Yli-Piipari S, Selph E, Lewis R, Laing E, Hollingsworth T, Parris K, Hartzell D. Improving Dietary Behaviors Among Guardians of Overweight Hispanic Adolescents: An Evaluation of the CORE Nutrition Education Program Journal of Nutrition Education and Behavior. 50. DOI: 10.1016/J.Jneb.2018.04.100	0.174
2014	L'herondelle K, Philippe R, Mignen O, Vetter I, Lewis RJ, Misery L, Le Garrec R. [In Process Citation]. Annales De Dermatologie Et De Vã©Nã©Rã©Ologie. 141: S90. PMID 24942436 DOI: 10.1016/J.Annder.2014.04.154	0.173
1973	Chan KK, Lewis RJ, Trager WF. Absolute configurations of the four warfarin alcohols. Journal of Medicinal Chemistry. 15: 1265-70. PMID 4635971 DOI: 10.1021/Jm00282A016	0.171
2022	Wacnik K, Rao VA, Chen X, Lafage L, Pazos M, Booth S, Vollmer W, Hobbs JK, Lewis RJ, Foster SJ. Penicillin-Binding Protein 1 (PBP1) of Staphylococcus aureus Has Multiple Essential Functions in Cell Division. Mbio. e0066922. PMID 35703435 DOI: 10.1128/mbio.00669-22	0.17
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