| Year |
Citation |
Score |
| 2021 |
Chen WY, Evangelista EA, Yang J, Kelly EJ, Yeung CK. Kidney Organoid and Microphysiological Kidney Chip Models to Accelerate Drug Development and Reduce Animal Testing. Frontiers in Pharmacology. 12: 695920. PMID 34381363 DOI: 10.3389/fphar.2021.695920 |
0.319 |
|
| 2020 |
Nieskens TTG, Persson M, Kelly EJ, Sjögren AK. A multi compartment human kidney proximal tubule-on-a-chip replicates cell polarization-dependent cisplatin toxicity. Drug Metabolism and Disposition: the Biological Fate of Chemicals. PMID 33020068 DOI: 10.1124/dmd.120.000098 |
0.34 |
|
| 2020 |
Basit A, Neradugomma NK, Wolford C, Fan PW, Murray B, Takahashi RH, Khojasteh SC, Smith BJ, Heyward S, Totah RA, Kelly EJ, Prasad B. CHARACTERIZATION OF DIFFERENTIAL TISSUE ABUNDANCE OF MAJOR NON-CYP ENZYMES IN HUMAN. Molecular Pharmaceutics. PMID 32955894 DOI: 10.1021/Acs.Molpharmaceut.0C00559 |
0.42 |
|
| 2020 |
Imaoka T, Yang J, Wang L, McDonald MG, Afsharinejad Z, Bammler TK, Van Ness K, Yeung CK, Rettie AE, Himmelfarb J, Kelly EJ. Microphysiological System Modeling of Ochratoxin A-Associated Nephrotoxicity. Toxicology. 152582. PMID 32905824 DOI: 10.1016/J.Tox.2020.152582 |
0.442 |
|
| 2020 |
Zhang A, Li CY, Kelly EJ, Sheppard L, Cui JY. Transcriptomic profiling of PBDE-exposed HepaRG cells unveils critical lncRNA- PCG pairs involved in intermediary metabolism. Plos One. 15: e0224644. PMID 32101552 DOI: 10.1371/Journal.Pone.0224644 |
0.352 |
|
| 2020 |
Shum S, Imaoka T, Huang W, Chang S, Yeung C, Himmelfarb J, Kelly E, Isoherranen N. Predicting renal clearance of morphine and morphine‐6‐glucuronide using the “organ‐on‐a‐chip” technology and physiologically‐based pharmacokinetic modeling The Faseb Journal. 34: 1-1. DOI: 10.1096/Fasebj.2020.34.S1.04121 |
0.303 |
|
| 2020 |
Imaoka T, Shum S, Chang S, Chapron A, Yeung CK, Himmelfarb J, Isoherranen N, Kelly EJ. P7 - Utilization of a microphysiological system to model renal secretion of opioids in humans Drug Metabolism and Pharmacokinetics. 35. DOI: 10.1016/J.Dmpk.2020.04.008 |
0.331 |
|
| 2019 |
Sakolish C, Chen Z, Dalaijamts C, Mitra K, Liu Y, Fulton T, Wade TL, Kelly EJ, Rusyn I, Chiu WA. Predicting tubular reabsorption with a human kidney proximal tubule tissue-on-a-chip and physiologically-based modeling. Toxicology in Vitro : An International Journal Published in Association With Bibra. 104752. PMID 31857146 DOI: 10.1016/J.Tiv.2019.104752 |
0.381 |
|
| 2019 |
Sachar M, Kelly EJ, Unadkat JD. Mechanisms of CYP3A Induction During Pregnancy: Studies in HepaRG Cells. The Aaps Journal. 21: 45. PMID 30919109 DOI: 10.1208/S12248-019-0316-Z |
0.354 |
|
| 2018 |
Weber EJ, Lidberg KA, Wang L, Bammler TK, MacDonald JW, Li MJ, Redhair M, Atkins WM, Tran C, Hines KM, Herron J, Xu L, Monteiro MB, Ramm S, Vaidya V, ... ... Kelly EJ, et al. Human kidney on a chip assessment of polymyxin antibiotic nephrotoxicity. Jci Insight. 3. PMID 30568031 DOI: 10.1172/Jci.Insight.123673 |
0.786 |
|
| 2018 |
Rayner SG, Phong KT, Xue J, Lih D, Shankland SJ, Kelly EJ, Himmelfarb J, Zheng Y. Reconstructing the Human Renal Vascular-Tubular Unit In Vitro. Advanced Healthcare Materials. e1801120. PMID 30379416 DOI: 10.1002/Adhm.201801120 |
0.395 |
|
| 2018 |
Monteiro MB, Ramm S, Chandrasekaran V, Boswell SA, Weber EJ, Lidberg KA, Kelly EJ, Vaidya VS. A High-Throughput Screen Identifies DYRK1A inhibitor ID-8 that Stimulates Human Kidney Tubular Epithelial Cell Proliferation. Journal of the American Society of Nephrology : Jasn. PMID 30361326 DOI: 10.1681/Asn.2018040392 |
0.773 |
|
| 2018 |
Sakolish C, Weber EJ, Kelly EJ, Himmelfarb J, Mouneimne R, Grimm FA, House JS, Wade T, Han A, Chiu WA, Rusyn I. Technology Transfer of the Microphysiological Systems: A Case Study of the Human Proximal Tubule Tissue Chip. Scientific Reports. 8: 14882. PMID 30291268 DOI: 10.1038/S41598-018-33099-2 |
0.769 |
|
| 2018 |
Bajaj P, Chowdhury SK, Yucha R, Kelly EJ, Xiao G. Emerging Kidney Models to Investigate Metabolism, Transport and Toxicity of Drugs and Xenobiotics. Drug Metabolism and Disposition: the Biological Fate of Chemicals. PMID 30076203 DOI: 10.1124/Dmd.118.082958 |
0.46 |
|
| 2018 |
Chapron BD, Chapron A, Phillips B, Okoli MC, Shen DD, Kelly EJ, Himmelfarb J, Thummel KE. Reevaluating the role of megalin in renal vitamin D homeostasis using a human cell-derived microphysiological system. Altex. PMID 29999169 DOI: 10.14573/Altex.1803161 |
0.357 |
|
| 2017 |
Chang SY, Weber EJ, Sidorenko VS, Chapron A, Yeung CK, Gao C, Mao Q, Shen D, Wang J, Rosenquist TA, Dickman KG, Neumann T, Grollman AP, Kelly EJ, Himmelfarb J, et al. Human liver-kidney model elucidates the mechanisms of aristolochic acid nephrotoxicity. Jci Insight. 2. PMID 29202460 DOI: 10.1172/Jci.Insight.95978 |
0.796 |
|
| 2017 |
Weber EJ, Himmelfarb J, Kelly EJ. Concise Review: Current and Emerging Biomarkers of Nephrotoxicity. Current Opinion in Toxicology. 4: 16-21. PMID 29057384 DOI: 10.1016/J.Cotox.2017.03.002 |
0.773 |
|
| 2017 |
Van Ness KP, Chang SY, Weber EJ, Zumpano D, Eaton DL, Kelly EJ. Microphysiological Systems to Assess Nonclinical Toxicity. Current Protocols in Toxicology. 73: 14.18.1-14.18.28. PMID 28777442 DOI: 10.1002/Cptx.27 |
0.797 |
|
| 2017 |
Lockhart CM, Smith TB, Yang P, Naidu M, Rettie AE, Nath A, Weleber R, Kelly EJ. Longitudinal characterisation of function and structure of Bietti crystalline dystrophy: report on a novel homozygous mutation in CYP4V2. The British Journal of Ophthalmology. PMID 28698241 DOI: 10.1136/Bjophthalmol-2016-309696 |
0.679 |
|
| 2017 |
Vernetti L, Gough A, Baetz N, Blutt S, Broughman JR, Brown JA, Foulke-Abel J, Hasan N, In J, Kelly E, Kovbasnjuk O, Repper J, Senutovitch N, Stabb J, Yeung C, et al. Corrigendum: Functional Coupling of Human Microphysiology Systems: Intestine, Liver, Kidney Proximal Tubule, Blood-Brain Barrier and Skeletal Muscle. Scientific Reports. 7: 44517. PMID 28300206 DOI: 10.1038/Srep44517 |
0.409 |
|
| 2017 |
Chang SY, Voellinger JL, Van Ness KP, Chapron B, Shaffer RM, Neumann T, White CC, Kavanagh TJ, Kelly EJ, Eaton DL. Characterization of rat or human hepatocytes cultured in microphysiological systems (MPS) to identify hepatotoxicity. Toxicology in Vitro : An International Journal Published in Association With Bibra. PMID 28089783 DOI: 10.1016/J.Tiv.2017.01.007 |
0.785 |
|
| 2016 |
Wang L, Collins C, Kelly EJ, Chu X, Ray AS, Salphati L, Xiao G, Lee C, Lai Y, Liao M, Mathias A, Evers R, Humphreys G, Hop CE, Kumer SC, et al. Transporter expression in liver tissue from subjects with alcoholic or hepatitis C cirrhosis quantified by targeted quantitative proteomics. Drug Metabolism and Disposition: the Biological Fate of Chemicals. PMID 27543206 DOI: 10.1124/Dmd.116.071050 |
0.332 |
|
| 2016 |
Weber EJ, Chapron A, Chapron BD, Voellinger JL, Lidberg KA, Yeung CK, Wang Z, Yamaura Y, Hailey DW, Neumann T, Shen DD, Thummel KE, Muczynski KA, Himmelfarb J, Kelly EJ. Development of a microphysiological model of human kidney proximal tubule function. Kidney International. 90: 627-37. PMID 27521113 DOI: 10.1016/J.Kint.2016.06.011 |
0.766 |
|
| 2016 |
Parkinson OT, Teitelbaum AM, Whittington D, Kelly EJ, Rettie AE. Species Differences in Microsomal Oxidation and Glucuronidation of 4-Ipomeanol: Relationship to Target Organ Toxicity. Drug Metabolism and Disposition: the Biological Fate of Chemicals. PMID 27468999 DOI: 10.1124/Dmd.116.070003 |
0.37 |
|
| 2016 |
Chang SY, Weber EJ, Van Ness KP, Eaton DL, Kelly EJ. Liver and Kidney on Chips: Microphysiological Models to Understand Transporter Function. Clinical Pharmacology and Therapeutics. PMID 27448090 DOI: 10.1002/Cpt.436 |
0.789 |
|
| 2016 |
Farooq M, Kelly EJ, Unadkat JD. CYP2D6 is inducible by endogenous and exogenous corticosteroids. Drug Metabolism and Disposition: the Biological Fate of Chemicals. PMID 26965986 DOI: 10.1124/Dmd.115.069229 |
0.376 |
|
| 2016 |
Voellinger JL, Kelly EJ. Pharmacogenetic profiling and metabolic activity of human embryonic stem cell derived hepatocytes: focus on CYP450-mediated oxidation Admet and Dmpk. 4: 62-83. DOI: 10.5599/Admet.4.2.280 |
0.793 |
|
| 2016 |
Kelly EJ, Voellinger JL. Stem Cells and Drug Metabolism Rsc Drug Discovery Series. 2016: 177-201. DOI: 10.1039/9781782622376-00177 |
0.76 |
|
| 2015 |
Adler M, Ramm S, Hafner M, Muhlich JL, Gottwald EM, Weber E, Jaklic A, Ajay AK, Svoboda D, Auerbach S, Kelly EJ, Himmelfarb J, Vaidya VS. A Quantitative Approach to Screen for Nephrotoxic Compounds In Vitro. Journal of the American Society of Nephrology : Jasn. PMID 26260164 DOI: 10.1681/Asn.2015010060 |
0.778 |
|
| 2015 |
Wiek C, Schmidt EM, Roellecke K, Freund M, Nakano M, Kelly EJ, Kaisers W, Yarov-Yarovoy V, Kramm CM, Rettie AE, Hanenberg H. Identification of amino acid determinants in CYP4B1 for optimal catalytic processing of 4-ipomeanol. The Biochemical Journal. 465: 103-14. PMID 25247810 DOI: 10.1042/Bj20140813 |
0.341 |
|
| 2014 |
Shuster DL, Risler LJ, Prasad B, Calamia JC, Voellinger JL, Kelly EJ, Unadkat JD, Hebert MF, Shen DD, Thummel KE, Mao Q. Identification of CYP3A7 for glyburide metabolism in human fetal livers. Biochemical Pharmacology. 92: 690-700. PMID 25450675 DOI: 10.1016/J.Bcp.2014.09.025 |
0.775 |
|
| 2014 |
Lockhart CM, Nakano M, Rettie AE, Kelly EJ. Generation and characterization of a murine model of Bietti crystalline dystrophy. Investigative Ophthalmology & Visual Science. 55: 5572-81. PMID 25118264 DOI: 10.1167/Iovs.13-13717 |
0.693 |
|
| 2014 |
Nakano M, Lockhart CM, Kelly EJ, Rettie AE. Ocular cytochrome P450s and transporters: roles in disease and endobiotic and xenobiotic disposition. Drug Metabolism Reviews. 46: 247-60. PMID 24856391 DOI: 10.3109/03602532.2014.921190 |
0.738 |
|
| 2013 |
Kelly EJ, Wang Z, Voellinger JL, Yeung CK, Shen DD, Thummel KE, Zheng Y, Ligresti G, Eaton DL, Muczynski KA, Duffield JS, Neumann T, Tourovskaia A, Fauver M, Kramer G, et al. Innovations in preclinical biology: ex vivo engineering of a human kidney tissue microperfusion system. Stem Cell Research & Therapy. 4: S17. PMID 24564863 DOI: 10.1186/Scrt378 |
0.796 |
|
| 2013 |
Lee N, Hebert MF, Prasad B, Easterling TR, Kelly EJ, Unadkat JD, Wang J. Effect of gestational age on mRNA and protein expression of polyspecific organic cation transporters during pregnancy. Drug Metabolism and Disposition: the Biological Fate of Chemicals. 41: 2225-32. PMID 24101703 DOI: 10.1124/Dmd.113.054072 |
0.34 |
|
| 2013 |
van der Wilden GM, Velmahos GC, Joseph DK, Jacobs L, Debusk MG, Adams CA, Gross R, Burkott B, Agarwal S, Maung AA, Johnson DC, Gates J, Kelly E, Michaud Y, Charash WE, et al. Successful nonoperative management of the most severe blunt renal injuries: a multicenter study of the research consortium of New England Centers for Trauma. Jama Surgery. 148: 924-31. PMID 23945834 DOI: 10.1001/Jamasurg.2013.2747 |
0.307 |
|
| 2013 |
Parkinson OT, Liggitt HD, Rettie AE, Kelly EJ. Generation and characterization of a Cyp4b1 null mouse and the role of CYP4B1 in the activation and toxicity of Ipomeanol. Toxicological Sciences : An Official Journal of the Society of Toxicology. 134: 243-50. PMID 23748241 DOI: 10.1093/Toxsci/Kft123 |
0.363 |
|
| 2012 |
Nakano M, Kelly EJ, Wiek C, Hanenberg H, Rettie AE. CYP4V2 in Bietti's crystalline dystrophy: ocular localization, metabolism of ω-3-polyunsaturated fatty acids, and functional deficit of the p.H331P variant. Molecular Pharmacology. 82: 679-86. PMID 22772592 DOI: 10.1124/Mol.112.080085 |
0.374 |
|
| 2012 |
Takakusa H, Mohar I, Kavanagh TJ, Kelly EJ, Kaspera R, Nelson SD. Protein tyrosine nitration of mitochondrial carbamoyl phosphate synthetase 1 and its functional consequences. Biochemical and Biophysical Research Communications. 420: 54-60. PMID 22402285 DOI: 10.1016/J.Bbrc.2012.02.114 |
0.302 |
|
| 2011 |
Ho MT, Kelly EJ, Bodor M, Bui T, Kowdley KV, Ho RJ. Novel cytochrome P450-2D6 promoter sequence variations in hepatitis C positive and negative subjects. Annals of Hepatology. 10: 327-32. PMID 21677335 DOI: 10.1016/S1665-2681(19)31545-5 |
0.306 |
|
| 2002 |
Kelly EJ, Erickson KE, Sengstag C, Eaton DL. Expression of human microsomal epoxide hydrolase in Saccharomyces cerevisiae reveals a functional role in aflatoxin B1 detoxification. Toxicological Sciences : An Official Journal of the Society of Toxicology. 65: 35-42. PMID 11752683 DOI: 10.1093/Toxsci/65.1.35 |
0.611 |
|
| 2001 |
Eaton DL, Bammler TK, Kelly EJ. Interindividual differences in response to chemoprotection against aflatoxin-induced hepatocarcinogenesis: Implications for human biotransformation enzyme polymorphisms Advances in Experimental Medicine and Biology. 500: 559-576. PMID 11764998 DOI: 10.1007/978-1-4615-0667-6_85 |
0.608 |
|
| 2001 |
Cheesman MJ, Kneller MB, Kelly EJ, Thompson SJ, Yeung CK, Eaton DL, Rettie AE. Purification and characterization of hexahistidine-tagged cyclohexanone monooxygenase expressed in Saccharomyces cerevisiae and Escherichia coli. Protein Expression and Purification. 21: 81-6. PMID 11162390 DOI: 10.1006/Prep.2000.1340 |
0.533 |
|
| 2000 |
Wang C, Bammler TK, Guo Y, Kelly EJ, Eaton DL. Mu-Class GSTs are responsible for aflatoxin B1-8,9-epoxide-conjugating activity in the nonhuman primate Macaca fascicularis liver Toxicological Sciences. 56: 26-36. PMID 10869451 DOI: 10.1093/Toxsci/56.1.26 |
0.565 |
|
| 1998 |
Tonge RP, Kelly EJ, Bruschi SA, Kalhorn T, Eaton DL, Nebert DW, Nelson SD. Role of CYP1A2 in the hepatotoxicity of acetaminophen: Investigations using Cyp1a2 null mice Toxicology and Applied Pharmacology. 153: 102-108. PMID 9875304 DOI: 10.1006/Taap.1998.8543 |
0.571 |
|
| 1998 |
Payne AS, Kelly EJ, Gitlin JD. Functional expression of the Wilson disease protein reveals mislocalization and impaired copper-dependent trafficking of the common H1069Q mutation. Proceedings of the National Academy of Sciences of the United States of America. 95: 10854-9. PMID 9724794 DOI: 10.1073/Pnas.95.18.10854 |
0.309 |
|
| 1998 |
Quaife CJ, Kelly EJ, Masters BA, Brinster RL, Palmiter RD. Ectopic expression of metallothionein-III causes pancreatic acinar cell necrosis in transgenic mice. Toxicology and Applied Pharmacology. 148: 148-57. PMID 9465274 DOI: 10.1006/Taap.1997.8321 |
0.471 |
|
| 1997 |
Kelly EJ, Sandgren EP, Brinster RL, Palmiter RD. A pair of adjacent glucocorticoid response elements regulate expression of two mouse metallothionein genes. Proceedings of the National Academy of Sciences of the United States of America. 94: 10045-50. PMID 9294160 DOI: 10.1073/Pnas.94.19.10045 |
0.456 |
|
| 1996 |
Kelly EJ, Quaife CJ, Froelick GJ, Palmiter RD. Metallothionein I and II protect against zinc deficiency and zinc toxicity in mice. The Journal of Nutrition. 126: 1782-90. PMID 8683339 DOI: 10.1093/Jn/126.7.1782 |
0.461 |
|
| 1996 |
Kelly EJ, Palmiter RD. A murine model of Menkes disease reveals a physiological function of metallothionein. Nature Genetics. 13: 219-22. PMID 8640230 DOI: 10.1038/Ng0696-219 |
0.465 |
|
| 1995 |
Erickson JC, Masters BA, Kelly EJ, Brinster RL, Palmiter RD. Expression of human metallothionein-III in transgenic mice. Neurochemistry International. 27: 35-41. PMID 7655346 DOI: 10.1016/0197-0186(94)00166-R |
0.467 |
|
| 1994 |
Masters BA, Kelly EJ, Quaife CJ, Brinster RL, Palmiter RD. Targeted disruption of metallothionein I and II genes increases sensitivity to cadmium. Proceedings of the National Academy of Sciences of the United States of America. 91: 584-8. PMID 8290567 DOI: 10.1073/Pnas.91.2.584 |
0.486 |
|
| 1994 |
Quaife CJ, Findley SD, Erickson JC, Froelick GJ, Kelly EJ, Zambrowicz BP, Palmiter RD. Induction of a new metallothionein isoform (MT-IV) occurs during differentiation of stratified squamous epithelia. Biochemistry. 33: 7250-9. PMID 8003488 DOI: 10.1021/Bi00189A029 |
0.473 |
|
| 1994 |
Masters B, Quaife C, Erickson J, Kelly E, Froelick G, Zambrowicz B, Brinster R, Palmiter R. Metallothionein III is expressed in neurons that sequester zinc in synaptic vesicles The Journal of Neuroscience. 14: 5844-5857. DOI: 10.1523/Jneurosci.14-10-05844.1994 |
0.436 |
|
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