Takaomi Saido - Publications

Affiliations: 
RIKEN 
Area:
Neuropathology, Proteolysis

429 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2022 Kamei N, Hashimoto A, Tanaka E, Murata K, Yamaguchi M, Yokoyama N, Kato M, Oki K, Saito T, Saido TC, Takeda-Morishita M. Therapeutic effects of anti-amyloid β antibody after intravenous injection and efficient nose-to-brain delivery in Alzheimer's disease mouse model. Drug Delivery and Translational Research. PMID 35015254 DOI: 10.1007/s13346-022-01117-6  1
2021 Mizuno Y, Abolhassani N, Mazzei G, Sakumi K, Saito T, Saido TC, Ninomiya T, Iwaki T, Yamasaki R, Kira JI, Nakabeppu Y. MUTYH Actively Contributes to Microglial Activation and Impaired Neurogenesis in the Pathogenesis of Alzheimer's Disease. Oxidative Medicine and Cellular Longevity. 2021: 8635088. PMID 34970419 DOI: 10.1155/2021/8635088  1
2021 Britz J, Ojo E, Dhukhwa A, Saito T, Saido TC, Hascup ER, Hascup KN, Tischkau SA. Assessing Sex-Specific Circadian, Metabolic, and Cognitive Phenotypes in the AβPP/PS1 and APPNL - F/NL - F Models of Alzheimer's Disease. Journal of Alzheimer's Disease : Jad. PMID 34897085 DOI: 10.3233/JAD-210629  1
2021 Mizuno Y, Abolhassani N, Mazzei G, Saito T, Saido TC, Yamasaki R, Kira JI, Nakabeppu Y. Deficiency of MTH1 and/or OGG1 increases the accumulation of 8-oxoguanine in the brain of the App knock-in mouse model of Alzheimer's disease, accompanied by accelerated microgliosis and reduced anxiety-like behavior. Neuroscience Research. PMID 34838904 DOI: 10.1016/j.neures.2021.11.009  1
2021 Liu X, Zhou Q, Zhang JH, Wang KY, Saito T, Saido TC, Wang X, Gao X, Azuma K. Microglia-Based Sex-Biased Neuropathology in Early-Stage Alzheimer's Disease Model Mice and the Potential Pharmacologic Efficacy of Dioscin. Cells. 10. PMID 34831483 DOI: 10.3390/cells10113261  1
2021 Pauls E, Bayod S, Mateo L, Alcalde V, Juan-Blanco T, Sánchez-Soto M, Saido TC, Saito T, Berrenguer-Llergo A, Attolini CS, Gay M, de Oliveira E, Duran-Frigola M, Aloy P. Identification and drug-induced reversion of molecular signatures of Alzheimer's disease onset and progression in App, App, and 3xTg-AD mouse models. Genome Medicine. 13: 168. PMID 34702310 DOI: 10.1186/s13073-021-00983-y  1
2021 Tanaka H, Kondo K, Fujita K, Homma H, Tagawa K, Jin X, Jin M, Yoshioka Y, Takayama S, Masuda H, Tokuyama R, Nakazaki Y, Saito T, Saido T, Murayama S, et al. HMGB1 signaling phosphorylates Ku70 and impairs DNA damage repair in Alzheimer's disease pathology. Communications Biology. 4: 1175. PMID 34635772 DOI: 10.1038/s42003-021-02671-4  1
2021 Wu X, Saito T, Saido TC, Barron AM, Ruedl C. Microglia and CD206 border-associated mouse macrophages maintain their embryonic origin during Alzheimer's disease. Elife. 10. PMID 34609281 DOI: 10.7554/eLife.71879  1
2021 Hoshi K, Ito H, Abe E, Fuwa TJ, Kanno M, Murakami Y, Abe M, Murakami T, Yoshihara A, Ugawa Y, Saito T, Saido TC, Matsumoto K, Yamaguchi Y, Furukawa K, et al. Transferrin Biosynthesized in the Brain Is a Novel Biomarker for Alzheimer's Disease. Metabolites. 11. PMID 34564432 DOI: 10.3390/metabo11090616  1
2021 Castillo E, Leon J, Mazzei G, Abolhassani N, Haruyama N, Saito T, Saido T, Hokama M, Iwaki T, Ohara T, Ninomiya T, Kiyohara Y, Sakumi K, LaFerla FM, Nakabeppu Y. Author Correction: Comparative profiling of cortical gene expression in Alzheimer's disease patients and mouse models demonstrates a link between amyloidosis and neuroinflammation. Scientific Reports. 11: 18377. PMID 34504282 DOI: 10.1038/s41598-021-97918-9  1
2021 Hata S, Kano K, Kikuchi K, Kinoshita S, Sobu Y, Saito H, Saito T, Saido TC, Sano Y, Taru H, Aoki J, Komano H, Tomita T, Natori S, Suzuki T. Suppression of amyloid-β secretion from neurons by cis-9, trans-11-octadecadienoic acid, an isomer of conjugated linoleic acid. Journal of Neurochemistry. PMID 34379812 DOI: 10.1111/jnc.15490  1
2021 Bettegazzi B, Sebastian Monasor L, Bellani S, Codazzi F, Restelli LM, Colombo AV, Deigendesch N, Frank S, Saito T, Saido TC, Lammich S, Tahirovic S, Grohovaz F, Zacchetti D. Casein Kinase 2 dependent phosphorylation of eIF4B regulates BACE1 expression in Alzheimer's disease. Cell Death & Disease. 12: 769. PMID 34349120 DOI: 10.1038/s41419-021-04062-3  1
2021 Sato K, Watamura N, Fujioka R, Mihira N, Sekiguchi M, Nagata K, Ohshima T, Saito T, Saido TC, Sasaguri H. A 3 generation mouse model of Alzheimer's disease shows early and increased cored plaque pathology composed of wild-type human amyloid β peptide. The Journal of Biological Chemistry. 101004. PMID 34329683 DOI: 10.1016/j.jbc.2021.101004  1
2021 Benitez DP, Jiang S, Wood J, Wang R, Hall CM, Peerboom C, Wong N, Stringer KM, Vitanova KS, Smith VC, Joshi D, Saito T, Saido TC, Hardy J, Hanrieder J, et al. Knock-in models related to Alzheimer's disease: synaptic transmission, plaques and the role of microglia. Molecular Neurodegeneration. 16: 47. PMID 34266459 DOI: 10.1186/s13024-021-00457-0  1
2021 Mazzei G, Ikegami R, Abolhassani N, Haruyama N, Sakumi K, Saito T, Saido TC, Nakabeppu Y. A high-fat diet exacerbates the Alzheimer's disease pathology in the hippocampus of the App knock-in mouse model. Aging Cell. e13429. PMID 34245097 DOI: 10.1111/acel.13429  1
2021 Barrett T, Stangis KA, Saito T, Saido T, Park KHJ. Neuronal Cell Cycle Re-Entry Enhances Neuropathological Features in AppNLF Knock-In Mice. Journal of Alzheimer's Disease : Jad. PMID 34219712 DOI: 10.3233/JAD-210091  1
2021 Sharoar MG, Palko S, Ge Y, Saido TC, Yan R. Accumulation of saposin in dystrophic neurites is linked to impaired lysosomal functions in Alzheimer's disease brains. Molecular Neurodegeneration. 16: 45. PMID 34215298 DOI: 10.1186/s13024-021-00464-1  0.01
2021 Sakakibara Y, Hirota Y, Ibaraki K, Takei K, Chikamatsu S, Tsubokawa Y, Saito T, Saido TC, Sekiya M, Iijima KM. Widespread Reduced Density of Noradrenergic Locus Coeruleus Axons in the App Knock-In Mouse Model of Amyloid-β Amyloidosis. Journal of Alzheimer's Disease : Jad. PMID 34180416 DOI: 10.3233/JAD-210385  1
2021 Meier SR, Sehlin D, Roshanbin S, Lim Falk V, Saito T, Saido TC, Neumann U, Rokka J, Eriksson J, Syvanen S. C-PIB and I-antibody PET provide differing estimates of brain amyloid-beta after therapeutic intervention. Journal of Nuclear Medicine : Official Publication, Society of Nuclear Medicine. PMID 34088777 DOI: 10.2967/jnumed.121.262083  1
2021 Sasai K, Tabu K, Saito T, Matsuba Y, Saido TC, Tanaka S. Difference in the malignancy between RAS and GLI1-transformed astrocytes is associated with frequency of p27-positive cells in xenograft tissues. Pathology, Research and Practice. 223: 153465. PMID 33989885 DOI: 10.1016/j.prp.2021.153465  1
2021 Takamura R, Mizuta K, Sekine Y, Islam T, Saito T, Sato M, Ohkura M, Nakai J, Ohshima T, Saido TC, Hayashi Y. Modality specific impairment of hippocampal CA1 neurons of Alzheimer's disease model mice. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. PMID 33980545 DOI: 10.1523/JNEUROSCI.0208-21.2021  1
2021 Szaruga M, Munteanu B, Lismont S, Veugelen S, Horré K, Mercken M, Saido TC, Ryan NS, De Vos T, Savvides SN, Gallardo R, Schymkowitz J, Rousseau F, Fox NC, Hopf C, et al. Alzheimer's-causing mutations shift Aβ length by destabilizing γ-secretase-Aβn interactions. Cell. 184: 2257-2258. PMID 33861967 DOI: 10.1016/j.cell.2021.03.058  1
2021 Clayton K, Delpech JC, Herron S, Iwahara N, Ericsson M, Saito T, Saido TC, Ikezu S, Ikezu T. Correction to: Plaque associated microglia hyper-secrete extracellular vesicles and accelerate tau propagation in a humanized APP mouse model. Molecular Neurodegeneration. 16: 24. PMID 33853665 DOI: 10.1186/s13024-021-00447-2  1
2021 Nakamura Y, Yamamoto T, Xu X, Kobayashi S, Tanaka S, Tamitani M, Saito T, Saido TC, Yano M. Enhancing calmodulin binding to ryanodine receptor is crucial to limit neuronal cell loss in Alzheimer disease. Scientific Reports. 11: 7289. PMID 33790404 DOI: 10.1038/s41598-021-86822-x  1
2021 Muniappan L, Okuyama M, Javidan A, Thiagarajan D, Jiang W, Moorleghen JJ, Yang L, Balakrishnan A, Howatt DA, Uchida HA, Saido TC, Subramanian V. Inducible Depletion of Calpain-2 Mitigates Abdominal Aortic Aneurysm in Mice. Arteriosclerosis, Thrombosis, and Vascular Biology. ATVBAHA120315546. PMID 33761765 DOI: 10.1161/ATVBAHA.120.315546  1
2021 Zhou X, Ji B, Seki C, Nagai Y, Minamimoto T, Fujinaga M, Zhang MR, Saito T, Saido TC, Suhara T, Kimura Y, Higuchi M. PET imaging of colony-stimulating factor 1 receptor: A head-to-head comparison of a novel radioligand, C-GW2580, and C-CPPC, in mouse models of acute and chronic neuroinflammation and a rhesus monkey. Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism. 271678X211004146. PMID 33757319 DOI: 10.1177/0271678X211004146  1
2021 Clayton K, Delpech JC, Herron S, Iwahara N, Ericsson M, Saito T, Saido TC, Ikezu S, Ikezu T. Plaque associated microglia hyper-secrete extracellular vesicles and accelerate tau propagation in a humanized APP mouse model. Molecular Neurodegeneration. 16: 18. PMID 33752701 DOI: 10.1186/s13024-021-00440-9  1
2021 Sutoko S, Masuda A, Kandori A, Sasaguri H, Saito T, Saido TC, Funane T. Early Identification of Alzheimer's Disease in Mouse Models: Application of Deep Neural Network Algorithm to Cognitive Behavioral Parameters. Iscience. 24: 102198. PMID 33733064 DOI: 10.1016/j.isci.2021.102198  1
2021 Taslima F, Jung CG, Zhou C, Abdelhamid M, Abdullah M, Goto T, Saito T, Saido TC, Michikawa M. Tooth Loss Induces Memory Impairment and Gliosis in App Knock-In Mouse Models of Alzheimer's Disease. Journal of Alzheimer's Disease : Jad. PMID 33720883 DOI: 10.3233/JAD-201055  1
2021 Maeda J, Minamihisamatsu T, Shimojo M, Zhou X, Ono M, Matsuba Y, Ji B, Ishii H, Ogawa M, Akatsu H, Kaneda D, Hashizume Y, Robinson JL, Lee VM, Saito T, ... Saido TC, et al. Distinct microglial response against Alzheimer's amyloid and tau pathologies characterized by P2Y12 receptor. Brain Communications. 3: fcab011. PMID 33644757 DOI: 10.1093/braincomms/fcab011  1
2021 Kundu P, Torres ERS, Stagaman K, Kasschau K, Okhovat M, Holden S, Ward S, Nevonen KA, Davis BA, Saito T, Saido TC, Carbone L, Sharpton TJ, Raber J. Integrated analysis of behavioral, epigenetic, and gut microbiome analyses in App, App, and wild type mice. Scientific Reports. 11: 4678. PMID 33633159 DOI: 10.1038/s41598-021-83851-4  1
2021 Doostdar N, Airey J, Radulescu CI, Melgosa-Ecenarro L, Zabouri N, Pavlidi P, Kopanitsa M, Saito T, Saido T, Barnes SJ. Multi-scale network imaging in a mouse model of amyloidosis. Cell Calcium. 95: 102365. PMID 33610083 DOI: 10.1016/j.ceca.2021.102365  1
2021 Nakano M, Mitsuishi Y, Liu L, Watanabe N, Hibino E, Hata S, Saito T, Saido TC, Murayama S, Kasuga K, Ikeuchi T, Suzuki T, Nishimura M. Extracellular Release of ILEI/FAM3C and Amyloid-β Is Associated with the Activation of Distinct Synapse Subpopulations. Journal of Alzheimer's Disease : Jad. PMID 33492290 DOI: 10.3233/JAD-201174  1
2021 Vandenabeele M, Veys L, Lemmens S, Hadoux X, Gelders G, Masin L, Serneels L, Theunis J, Saito T, Saido TC, Jayapala M, De Boever P, De Strooper B, Stalmans I, van Wijngaarden P, et al. The App mouse retina is a site for preclinical Alzheimer's disease diagnosis and research. Acta Neuropathologica Communications. 9: 6. PMID 33407903 DOI: 10.1186/s40478-020-01102-5  1
2021 Sobue A, Komine O, Hara Y, Endo F, Mizoguchi H, Watanabe S, Murayama S, Saito T, Saido TC, Sahara N, Higuchi M, Ogi T, Yamanaka K. Microglial gene signature reveals loss of homeostatic microglia associated with neurodegeneration of Alzheimer's disease. Acta Neuropathologica Communications. 9: 1. PMID 33402227 DOI: 10.1186/s40478-020-01099-x  1
2020 Salobrar-García E, López-Cuenca I, Sánchez-Puebla L, de Hoz R, Fernández-Albarral JA, Ramírez AI, Bravo-Ferrer I, Medina V, Moro MA, Saido TC, Saito T, Salazar JJ, Ramírez JM. Retinal Thickness Changes Over Time in a Murine AD Model APP . Frontiers in Aging Neuroscience. 12: 625642. PMID 33542683 DOI: 10.3389/fnagi.2020.625642  1
2020 de Vidania S, Palomares-Perez I, Frank-García A, Saito T, Saido TC, Draffin J, Szaruga M, Chávez-Gutierrez L, Calero M, Medina M, Guix FX, Dotti CG. Prodromal Alzheimer's Disease: Constitutive Upregulation of Neuroglobin Prevents the Initiation of Alzheimer's Pathology. Frontiers in Neuroscience. 14: 562581. PMID 33343276 DOI: 10.3389/fnins.2020.562581  1
2020 Shahnur A, Nakano M, Ishihara S, Kakuda N, Miyasaka T, Uchiyama H, Shirai Y, Moniruzzaman M, Saito T, Saido TC, Nishimura M, Funamoto S. A potential defense mechanism against amyloid deposition in cerebellum. Biochemical and Biophysical Research Communications. 535: 25-32. PMID 33340762 DOI: 10.1016/j.bbrc.2020.12.036  1
2020 Hark TJ, Rao NR, Castillon C, Basta T, Smukowski S, Bao H, Upadhyay A, Bomba-Warczak E, Nomura T, O'Toole ET, Morgan GP, Ali L, Saito T, Guillermier C, Saido TC, et al. Pulse-Chase Proteomics of the App Knockin Mouse Models of Alzheimer's Disease Reveals that Synaptic Dysfunction Originates in Presynaptic Terminals. Cell Systems. PMID 33326751 DOI: 10.1016/j.cels.2020.11.007  1
2020 Tanaka T, Hirai S, Hosokawa M, Saito T, Sakuma H, Saido T, Hasegawa M, Okado H. Early-life stress induces the development of Alzheimer's disease pathology via angiopathy. Experimental Neurology. 113552. PMID 33309748 DOI: 10.1016/j.expneurol.2020.113552  1
2020 Saifullah MAB, Komine O, Dong Y, Fukumoto K, Sobue A, Endo F, Saito T, Saido TC, Yamanaka K, Mizoguchi H. Touchscreen-based location discrimination and paired associate learning tasks detect cognitive impairment at an early stage in an App knock-in mouse model of Alzheimer's disease. Molecular Brain. 13: 147. PMID 33183323 DOI: 10.1186/s13041-020-00690-6  1
2020 Nieraad H, de Bruin N, Arne O, Hofmann MCJ, Schmidt M, Saito T, Saido TC, Gurke R, Schmidt D, Till U, Parnham MJ, Geisslinger G. Impact of Hyperhomocysteinemia and Different Dietary Interventions on Cognitive Performance in a Knock-in Mouse Model for Alzheimer's Disease. Nutrients. 12. PMID 33114054 DOI: 10.3390/nu12113248  1
2020 Chiasseu M, Fesharaki A, Saito T, Saido TC, Strittmatter SM. Gene-environment interaction promotes Alzheimer's risk as revealed by synergy of repeated mild traumatic brain injury and mouse App knock-in. Neurobiology of Disease. 145: 105059. PMID 32858147 DOI: 10.1016/J.Nbd.2020.105059  1
2020 Latif-Hernandez A, Sabanov V, Ahmed T, Craessaerts K, Saito T, Saido T, Balschun D. The two faces of synaptic failure in App knock-in mice. Alzheimer's Research & Therapy. 12: 100. PMID 32838792 DOI: 10.1186/s13195-020-00667-6  1
2020 Chen WT, Lu A, Craessaerts K, Pavie B, Sala Frigerio C, Corthout N, Qian X, Laláková J, Kühnemund M, Voytyuk I, Wolfs L, Mancuso R, Salta E, Balusu S, Snellinx A, ... ... Saido TC, et al. Spatial Transcriptomics and In Situ Sequencing to Study Alzheimer's Disease. Cell. PMID 32702314 DOI: 10.1016/j.cell.2020.06.038  1
2020 Jun H, Bramian A, Soma S, Saito T, Saido TC, Igarashi KM. Disrupted Place Cell Remapping and Impaired Grid Cells in a Knockin Model of Alzheimer's Disease. Neuron. PMID 32697942 DOI: 10.1016/J.Neuron.2020.06.023  1
2020 Narukawa M, Takahashi S, Saito T, Saido TC, Misaka T. Analysis of Taste Sensitivities in App Knock-In Mouse Model of Alzheimer's Disease. Journal of Alzheimer's Disease : Jad. PMID 32568206 DOI: 10.3233/JAD-200284  1
2020 Sebastian Monasor L, Müller SA, Colombo AV, Tanrioever G, König J, Roth S, Liesz A, Berghofer A, Piechotta A, Prestel M, Saito T, Saido TC, Herms J, Willem M, Haass C, et al. Fibrillar Aβ triggers microglial proteome alterations and dysfunction in Alzheimer mouse models. Elife. 9. PMID 32510331 DOI: 10.7554/Elife.54083  1
2020 Sos KE, Mayer MI, Takács VT, Major A, Bardóczi Z, Beres BM, Szeles T, Saito T, Saido TC, Mody I, Freund TF, Nyiri G. Amyloid β induces interneuron-specific changes in the hippocampus of APPNL-F mice. Plos One. 15: e0233700. PMID 32469963 DOI: 10.1371/journal.pone.0233700  1
2020 Susaki EA, Shimizu C, Kuno A, Tainaka K, Li X, Nishi K, Morishima K, Ono H, Ode KL, Saeki Y, Miyamichi K, Isa K, Yokoyama C, Kitaura H, Ikemura M, ... ... Saido TC, et al. Versatile whole-organ/body staining and imaging based on electrolyte-gel properties of biological tissues. Nature Communications. 11: 1982. PMID 32341345 DOI: 10.1038/S41467-020-15906-5  1
2020 Maezono SEB, Kanuka M, Tatsuzawa C, Morita M, Kawano T, Kashiwagi M, Nondhalee P, Sakaguchi M, Saito T, Saido TC, Hayashi Y. Progressive Changes in Sleep and Its Relations to Amyloid-β Distribution and Learning in Single Knock-In Mice. Eneuro. 7. PMID 32321771 DOI: 10.1523/ENEURO.0093-20.2020  1
2020 Schedin-Weiss S, Nilsson P, Sandebring-Matton A, Axenhus M, Sekiguchi M, Saito T, Winblad B, Saido T, Tjernberg LO. Proteomics Time-Course Study of App Knock-In Mice Reveals Novel Presymptomatic Aβ42-Induced Pathways to Alzheimer's Disease Pathology. Journal of Alzheimer's Disease : Jad. PMID 32280097 DOI: 10.3233/Jad-200028  1
2020 Hongo N, Takamura Y, Nishimaru H, Matsumoto J, Tobe K, Saito T, Saido TC, Nishijo H. Astaxanthin Ameliorated Parvalbumin-Positive Neuron Deficits and Alzheimer's Disease-Related Pathological Progression in the Hippocampus of Mice. Frontiers in Pharmacology. 11: 307. PMID 32218736 DOI: 10.3389/Fphar.2020.00307  1
2020 Izumi H, Sato K, Kojima K, Saito T, Saido TC, Fukunaga K. Oral glutathione administration inhibits the oxidative stress and the inflammatory responses in App knock-in mice. Neuropharmacology. 168: 108026. PMID 32130977 DOI: 10.1016/j.neuropharm.2020.108026  1
2020 Tanaka H, Homma H, Fujita K, Kondo K, Yamada S, Jin X, Waragai M, Ohtomo G, Iwata A, Tagawa K, Atsuta N, Katsuno M, Tomita N, Furukawa K, Saito Y, ... ... Saido T, et al. YAP-dependent necrosis occurs in early stages of Alzheimer's disease and regulates mouse model pathology. Nature Communications. 11: 507. PMID 31980612 DOI: 10.1038/S41467-020-14353-6  1
2020 Zhang F, Gannon M, Chen Y, Yan S, Zhang S, Feng W, Tao J, Sha B, Liu Z, Saito T, Saido T, Keene CD, Jiao K, Roberson ED, Xu H, et al. β-amyloid redirects norepinephrine signaling to activate the pathogenic GSK3β/tau cascade. Science Translational Medicine. 12. PMID 31941827 DOI: 10.1126/Scitranslmed.Aay6931  1
2020 Uruno A, Matsumaru D, Ryoke R, Saito R, Kadoguchi S, Saigusa D, Saito T, Saido TC, Kawashima R, Yamamoto M. Nrf2 Suppresses Oxidative Stress and Inflammation in Knock-in Alzheimer's Disease Model Mice. Molecular and Cellular Biology. PMID 31932477 DOI: 10.1128/Mcb.00467-19  1
2020 Rice HC, Marcassa G, Chrysidou I, Horré K, Young-Pearse TL, Müller UC, Saito T, Saido TC, Vassar R, de Wit J, De Strooper B. Contribution of GABAergic interneurons to amyloid-β plaque pathology in an APP knock-in mouse model. Molecular Neurodegeneration. 15: 3. PMID 31915042 DOI: 10.1186/S13024-019-0356-Y  1
2019 Shinohara M, Tashiro Y, Shinohara M, Hirokawa J, Suzuki K, Onishi-Takeya M, Mukouzono M, Takeda S, Saito T, Fukumori A, Saido TC, Morishita R, Sato N. Increased levels of Aβ42 decrease the lifespan of ob/ob mice with dysregulation of microglia and astrocytes. Faseb Journal : Official Publication of the Federation of American Societies For Experimental Biology. PMID 31907998 DOI: 10.1096/fj.201901028RR  1
2019 Nagata K, Saito T, Saido TC, Morihara T. Biology of splicing in Alzheimer's disease research. Progress in Molecular Biology and Translational Science. 168: 79-84. PMID 31699329 DOI: 10.1016/bs.pmbts.2019.08.003  1
2019 Aikawa T, Ren Y, Yamazaki Y, Tachibana M, Johnson MR, Anderson CT, Martens YA, Holm ML, Asmann YW, Saito T, Saido TC, Fitzgerald ML, Bu G, Kanekiyo T. ABCA7 haplodeficiency disturbs microglial immune responses in the mouse brain. Proceedings of the National Academy of Sciences of the United States of America. PMID 31690660 DOI: 10.1073/Pnas.1908529116  1
2019 Caleb AA, Akiyama T, Kimura A, Kimura Y, Takahashi-Jitsuki A, Nakamura H, Makihara H, Masukawa D, Nakabayashi J, Hirano H, Nakamura F, Saito T, Saido T, Goshima Y. Network-guided analysis of hippocampal proteome identifies novel proteins that colocalize with Aβ in a mice model of early-stage Alzheimer's disease. Neurobiology of Disease. 104603. PMID 31494281 DOI: 10.1016/j.nbd.2019.104603  1
2019 Ni J, Wu Z, Meng J, Saito T, Saido TC, Qing H, Nakanishi H. An impaired intrinsic microglial clock system induces neuroinflammatory alterations in the early stage of amyloid precursor protein knock-in mouse brain. Journal of Neuroinflammation. 16: 173. PMID 31470863 DOI: 10.1186/s12974-019-1562-9  1
2019 Casadomé-Perales Á, Matteis L, Alleva M, Infantes-Rodríguez C, Palomares-Pérez I, Saito T, Saido TC, Esteban JA, Nebreda AR, de la Fuente JM, Dotti CG. Inhibition of p38 MAPK in the brain through nasal administration of p38 inhibitor loaded in chitosan nanocapsules. Nanomedicine (London, England). PMID 31456488 DOI: 10.2217/Nnm-2018-0496  1
2019 Pervolaraki E, Hall SP, Foresteire D, Saito T, Saido TC, Whittington MA, Lever C, Dachtler J. Insoluble Aβ overexpression in an knock-in mouse model alters microstructure and gamma oscillations in the prefrontal cortex, and impacts on anxiety-related behaviours. Disease Models & Mechanisms. PMID 31439589 DOI: 10.1242/Dmm.040550  1
2019 Wang W, Tanokashira D, Fukui Y, Maruyama M, Kuroiwa C, Saito T, Saido TC, Taguchi A. Serine Phosphorylation of IRS1 Correlates with Aβ-Unrelated Memory Deficits and Elevation in Aβ Level Prior to the Onset of Memory Decline in AD. Nutrients. 11. PMID 31426549 DOI: 10.3390/nu11081942  1
2019 Sacher C, Blume T, Beyer L, Peters F, Eckenweber F, Sgobio C, Deussing M, Albert NL, Unterrainer M, Lindner S, Gildehaus FJ, von Ungern-Sternberg B, Brzak I, Neumann U, Saito T, ... Saido TC, et al. Longitudinal PET Monitoring of Amyloidosis and Microglial Activation in a Second Generation Amyloid-beta Mouse Model. Journal of Nuclear Medicine : Official Publication, Society of Nuclear Medicine. PMID 31302633 DOI: 10.2967/Jnumed.119.227322  1
2019 Manocha GD, Floden AM, Miller NM, Smith AJ, Nagamoto-Combs K, Saito T, Saido TC, Combs CK. Temporal progression of Alzheimer's disease in brains and intestines of transgenic mice. Neurobiology of Aging. 81: 166-176. PMID 31284126 DOI: 10.1016/J.Neurobiolaging.2019.05.025  1
2019 Saito T, Mihira N, Matsuba Y, Sasaguri H, Hashimoto S, Narasimhan S, Zhang B, Murayama S, Higuchi M, Lee VMY, Trojanowski JQ, Saido TC. Humanization of the entire murine gene provides a murine model of pathological human tau propagation. The Journal of Biological Chemistry. PMID 31273083 DOI: 10.1074/Jbc.Ra119.009487  1
2019 Hashimoto S, Matsuba Y, Kamano N, Mihira N, Sahara N, Takano J, Muramatsu SI, Saido TC, Saito T. Author Correction: Tau binding protein CAPON induces tau aggregation and neurodegeneration. Nature Communications. 10: 2964. PMID 31263162 DOI: 10.1038/s41467-019-10990-8  1
2019 Nortley R, Korte N, Izquierdo P, Hirunpattarasilp C, Mishra A, Jaunmuktane Z, Kyrargyri V, Pfeiffer T, Khennouf L, Madry C, Gong H, Richard-Loendt A, Huang W, Saito T, Saido TC, et al. Amyloid β oligomers constrict human capillaries in Alzheimer's disease via signaling to pericytes. Science (New York, N.Y.). PMID 31221773 DOI: 10.1126/Science.Aav9518  1
2019 Izuo N, Murakami K, Fujihara Y, Maeda M, Saito T, Saido TC, Irie K, Shimizu T. An App knock-in mouse inducing the formation of a toxic conformer of Aβ as a model for evaluating only oligomer-induced cognitive decline in Alzheimer's disease. Biochemical and Biophysical Research Communications. PMID 31164199 DOI: 10.1016/j.bbrc.2019.05.131  1
2019 Hashimoto S, Matsuba Y, Kamano N, Mihira N, Sahara N, Takano J, Muramatsu SI, Saido TC, Saito T. Tau binding protein CAPON induces tau aggregation and neurodegeneration. Nature Communications. 10: 2394. PMID 31160584 DOI: 10.1038/s41467-019-10278-x  1
2019 Hamaguchi T, Tsutsui-Kimura I, Mimura M, Saito T, Saido TC, Tanaka KF. AppNL-G-F/NL-G-F mice overall do not show impaired motivation, but cored amyloid plaques in the striatum are inversely correlated with motivation. Neurochemistry International. 104470. PMID 31102607 DOI: 10.1016/j.neuint.2019.104470  1
2019 Shirotani K, Hori Y, Yoshizaki R, Higuchi E, Colonna M, Saito T, Hashimoto S, Saito T, Saido TC, Iwata N. Aminophospholipids are signal-transducing TREM2 ligands on apoptotic cells. Scientific Reports. 9: 7508. PMID 31101881 DOI: 10.1038/s41598-019-43535-6  1
2019 Sala Frigerio C, Wolfs L, Fattorelli N, Thrupp N, Voytyuk I, Schmidt I, Mancuso R, Chen WT, Woodbury ME, Srivastava G, Möller T, Hudry E, Das S, Saido T, Karran E, et al. The Major Risk Factors for Alzheimer's Disease: Age, Sex, and Genes Modulate the Microglia Response to Aβ Plaques. Cell Reports. 27: 1293-1306.e6. PMID 31018141 DOI: 10.1016/J.Celrep.2019.03.099  1
2019 Liu Y, Cheng A, Li YJ, Yang Y, Kishimoto Y, Zhang S, Wang Y, Wan R, Raefsky SM, Lu D, Saito T, Saido T, Zhu J, Wu LJ, Mattson MP. SIRT3 mediates hippocampal synaptic adaptations to intermittent fasting and ameliorates deficits in APP mutant mice. Nature Communications. 10: 1886. PMID 31015456 DOI: 10.1038/S41467-019-09897-1  1
2019 Hui KK, Takashima N, Watanabe A, Chater TE, Matsukawa H, Nekooki-Machida Y, Nilsson P, Endo R, Goda Y, Saido TC, Yoshikawa T, Tanaka M. GABARAPs dysfunction by autophagy deficiency in adolescent brain impairs GABA receptor trafficking and social behavior. Science Advances. 5: eaau8237. PMID 30989111 DOI: 10.1126/sciadv.aau8237  1
2019 Sakakibara Y, Sekiya M, Saito T, Saido TC, Iijima KM. Amyloid-β plaque formation and reactive gliosis are required for induction of cognitive deficits in App knock-in mouse models of Alzheimer's disease. Bmc Neuroscience. 20: 13. PMID 30894120 DOI: 10.1186/s12868-019-0496-6  1
2019 Yamakage Y, Tsuiji H, Kohno T, Ogino H, Saito T, Saido TC, Hattori M. Reducing ADAMTS-3 Inhibits Amyloid β Deposition in App Knock-in Mouse. Biological & Pharmaceutical Bulletin. 42: 354-356. PMID 30828067 DOI: 10.1248/Bpb.B18-00899  1
2019 Petrache AL, Rajulawalla A, Shi A, Wetzel A, Saito T, Saido TC, Harvey K, Ali AB. Aberrant Excitatory-Inhibitory Synaptic Mechanisms in Entorhinal Cortex Microcircuits During the Pathogenesis of Alzheimer's Disease. Cerebral Cortex (New York, N.Y. : 1991). PMID 30766992 DOI: 10.1093/cercor/bhz016  1
2019 Wang S, Yabuki Y, Matsuo K, Xu J, Izumi H, Sakimura K, Saito T, Saido TC, Fukunaga K. Correction: T-type calcium channel enhancer SAK3 promotes dopamine and serotonin releases in the hippocampus in naive and amyloid precursor protein knock-in mice. Plos One. 14: e0211590. PMID 30682166 DOI: 10.1371/journal.pone.0211590  1
2018 Wang S, Yabuki Y, Matsuo K, Xu J, Izumi H, Sakimura K, Saito T, Saido TC, Fukunaga K. T-type calcium channel enhancer SAK3 promotes dopamine and serotonin releases in the hippocampus in naive and amyloid precursor protein knock-in mice. Plos One. 13: e0206986. PMID 30571684 DOI: 10.1371/journal.pone.0206986  1
2018 Saito T, Saido TC. Neuroinflammation in mouse models of Alzheimer's disease. Clinical & Experimental Neuroimmunology. 9: 211-218. PMID 30546389 DOI: 10.1111/cen3.12475  1
2018 Purro SA, Farrow MA, Linehan J, Nazari T, Thomas DX, Chen Z, Mengel D, Saito T, Saido T, Rudge P, Brandner S, Walsh DM, Collinge J. Transmission of amyloid-β protein pathology from cadaveric pituitary growth hormone. Nature. PMID 30546139 DOI: 10.1038/S41586-018-0790-Y  1
2018 Kiryu-Seo S, Nagata K, Saido TC, Kiyama H. New Insights of a Neuronal Peptidase DINE/ECEL1: Nerve Development, Nerve Regeneration and Neurogenic Pathogenesis. Neurochemical Research. PMID 30357652 DOI: 10.1007/S11064-018-2665-X  1
2018 Salas IH, Callaerts-Vegh Z, D'Hooge R, Saido TC, Dotti CG, De Strooper B. Increased Insoluble Amyloid-β Induces Negligible Cognitive Deficits in Old AppNL/NL Knock-In Mice. Journal of Alzheimer's Disease : Jad. PMID 30320577 DOI: 10.3233/Jad-180410  1
2018 Tanaka H, Kondo K, Chen X, Homma H, Tagawa K, Kerever A, Aoki S, Saito T, Saido T, Muramatsu SI, Fujita K, Okazawa H. The intellectual disability gene PQBP1 rescues Alzheimer's disease pathology. Molecular Psychiatry. PMID 30283027 DOI: 10.1038/s41380-018-0253-8  1
2018 Chen L, Saito T, Saido TC, Mody I. Novel Quantitative Analyses of Spontaneous Synaptic Events in Cortical Pyramidal Cells Reveal Subtle Parvalbumin-Expressing Interneuron Dysfunction in a Knock-In Mouse Model of Alzheimer's Disease. Eneuro. 5. PMID 30105300 DOI: 10.1523/ENEURO.0059-18.2018  1
2018 Mehla J, Deibel SH, Faraji J, Saito T, Saido TC, Mohajerani MH, McDonald RJ. Looking beyond the standard version of the Morris water task in the assessment of mouse models of cognitive deficits. Hippocampus. PMID 30069957 DOI: 10.1002/Hipo.22999  1
2018 Sakakibara Y, Sekiya M, Saito T, Saido TC, Iijima KM. Cognitive and emotional alterations in App knock-in mouse models of Aβ amyloidosis. Bmc Neuroscience. 19: 46. PMID 30055565 DOI: 10.1186/s12868-018-0446-8  1
2018 Sasaguri H, Nagata K, Sekiguchi M, Fujioka R, Matsuba Y, Hashimoto S, Sato K, Kurup D, Yokota T, Saido TC. Introduction of pathogenic mutations into the mouse Psen1 gene by Base Editor and Target-AID. Nature Communications. 9: 2892. PMID 30042426 DOI: 10.1038/s41467-018-05262-w  1
2018 Swartzlander DB, Propson NE, Roy ER, Saito T, Saido T, Wang B, Zheng H. Concurrent cell type-specific isolation and profiling of mouse brains in inflammation and Alzheimer's disease. Jci Insight. 3. PMID 29997299 DOI: 10.1172/Jci.Insight.121109  1
2018 Brown R, Lam AD, Gonzalez-Sulser A, Ying A, Jones M, Chou RC, Tzioras M, Jordan CY, Jedrasiak-Cape I, Hemonnot AL, Abou Jaoude M, Cole AJ, Cash SS, Saito T, Saido T, et al. Circadian and Brain State Modulation of Network Hyperexcitability in Alzheimer's Disease. Eneuro. 5. PMID 29780880 DOI: 10.1523/ENEURO.0426-17.2018  1
2018 Nagata K, Takahashi M, Matsuba Y, Okuyama-Uchimura F, Sato K, Hashimoto S, Saito T, Saido TC. Generation of App knock-in mice reveals deletion mutations protective against Alzheimer's disease-like pathology. Nature Communications. 9: 1800. PMID 29728560 DOI: 10.1038/s41467-018-04238-0  1
2018 Hashimoto S, Saido TC. Critical review: involvement of endoplasmic reticulum stress in the aetiology of Alzheimer's disease. Open Biology. 8. PMID 29695619 DOI: 10.1098/rsob.180024  1
2018 Shah D, Latif-Hernandez A, De Strooper B, Saito T, Saido T, Verhoye M, D'Hooge R, Van der Linden A. Spatial reversal learning defect coincides with hypersynchronous telencephalic BOLD functional connectivity in APP knock-in mice. Scientific Reports. 8: 6264. PMID 29674739 DOI: 10.1038/S41598-018-24657-9  1
2018 Loera-Valencia R, Piras A, Ismail MAM, Manchanda S, Eyjolfsdottir H, Saido TC, Johansson J, Eriksdotter M, Winblad B, Nilsson P. Targeting Alzheimer's Disease with Gene and Cell Therapies. Journal of Internal Medicine. PMID 29582495 DOI: 10.1111/Joim.12759  1
2018 Izumi H, Shinoda Y, Saito T, Saido T, Sato K, Yabuki Y, Matsumoto Y, Kanemitsu Y, Tomioka Y, Abolhassani N, Nakabeppu Y, Fukunaga K. The disease-modifying drug candidate, SAK3 improves cognitive impairment and inhibits amyloid beta deposition in App knock-in mice. Neuroscience. PMID 29510211 DOI: 10.1016/j.neuroscience.2018.02.031  1
2018 Salas IH, Weerasekera A, Ahmed T, Callaerts-Vegh Z, Himmelreich U, D'Hooge R, Balschun D, Saido TC, De Strooper B, Dotti CG. High fat diet treatment impairs hippocampal long-term potentiation without alterations of the core neuropathological features of Alzheimer disease. Neurobiology of Disease. PMID 29427755 DOI: 10.1016/J.Nbd.2018.02.001  1
2018 Peters DG, Pollack AN, Cheng KC, Sun D, Saido T, Haaf MP, Yang QX, Connor JR, Meadowcroft MD. Dietary lipophilic iron alters amyloidogenesis and microglial morphology in Alzheimer's disease knock-in APP mice. Metallomics : Integrated Biometal Science. PMID 29424844 DOI: 10.1039/C8Mt00004B  0.01
2018 Takano J, Mihira N, Fujioka R, Hosoki E, Chishti AH, Saido TC. Correction for Takano et al., "Vital Role of the Calpain-Calpastatin System for Placental-Integrity-Dependent Embryonic Survival". Molecular and Cellular Biology. 38. PMID 29378895 DOI: 10.1128/MCB.00614-17  1
2018 Nagata K, Mano T, Murayama S, Saido TC, Iwata A. DNA methylation level of the neprilysin promoter in Alzheimer's disease brains. Neuroscience Letters. PMID 29339171 DOI: 10.1016/j.neulet.2018.01.003  1
2018 Kidana K, Tatebe T, Ito K, Hara N, Kakita A, Saito T, Takatori S, Ouchi Y, Ikeuchi T, Makino M, Saido TC, Akishita M, Iwatsubo T, Hori Y, Tomita T. Loss of kallikrein-related peptidase 7 exacerbates amyloid pathology in Alzheimer's disease model mice. Embo Molecular Medicine. PMID 29311134 DOI: 10.15252/emmm.201708184  1
2018 Hashimoto S, Ishii A, Kamano N, Watamura N, Saito T, Oshima T, Yokosuka M, Saido TC. Endoplasmic reticulum stress responses in mouse models of Alzheimer disease: overexpression paradigm versus knock-in paradigm. The Journal of Biological Chemistry. PMID 29298895 DOI: 10.1074/Jbc.M117.811315  1
2017 Moriguchi S, Kita S, Fukaya M, Osanai M, Inagaki R, Sasaki Y, Izumi H, Horie K, Takeda J, Saito T, Sakagami H, Saido TC, Iwamoto T, Fukunaga K. Reduced expression of Na+/Ca2+ exchangers is associated with cognitive deficits seen in Alzheimer's disease model mice. Neuropharmacology. 131: 291-303. PMID 29274751 DOI: 10.1016/j.neuropharm.2017.12.037  1
2017 Castillo E, Leon J, Mazzei G, Abolhassani N, Haruyama N, Saito T, Saido T, Hokama M, Iwaki T, Ohara T, Ninomiya T, Kiyohara Y, Sakumi K, LaFerla FM, Nakabeppu Y. Comparative profiling of cortical gene expression in Alzheimer's disease patients and mouse models demonstrates a link between amyloidosis and neuroinflammation. Scientific Reports. 7: 17762. PMID 29259249 DOI: 10.1038/s41598-017-17999-3  1
2017 Hernandez AL, Shah D, Craessaerts K, Saido T, Saito T, De Strooper B, Van der Linden A, D'Hooge R. Subtle behavioral changes and increased prefrontal-hippocampal network synchronicity in APP(NL-G-F) mice before prominent plaque deposition. Behavioural Brain Research. PMID 29158112 DOI: 10.1016/j.bbr.2017.11.017  1
2017 Takano J, Mihira N, Fujioka R, Hosoki E, Chishti AH, Saido TC. Expression of Concern for Takano et al., "Vital Role of the Calpain-Calpastatin System for Placental-Integrity-Dependent Embryonic Survival". Molecular and Cellular Biology. 37. PMID 29133537 DOI: 10.1128/MCB.00530-17  1
2017 Nagata K, Takahashi M, Kiryu-Seo S, Kiyama H, Saido TC. Distinct functional consequences of ECEL1/DINE missense mutations in the pathogenesis of congenital contracture disorders. Acta Neuropathologica Communications. 5: 83. PMID 29132416 DOI: 10.1186/S40478-017-0486-9  1
2017 Orr AG, Lo I, Schumacher H, Ho K, Gill M, Guo W, Kim DH, Knox A, Saito T, Saido TC, Simms J, Toddes C, Wang X, Yu GQ, Mucke L. Istradefylline reduces memory deficits in aging mice with amyloid pathology. Neurobiology of Disease. PMID 29100987 DOI: 10.1016/J.Nbd.2017.10.014  1
2017 Mano T, Nagata K, Nonaka T, Tarutani A, Imamura T, Hashimoto T, Bannai T, Koshi-Mano K, Tsuchida T, Ohtomo R, Takahashi-Fujigasaki J, Yamashita S, Ohyagi Y, Yamasaki R, Tsuji S, ... ... Saido TC, et al. Neuron-specific methylome analysis reveals epigenetic regulation and tau-related dysfunction of BRCA1 in Alzheimer's disease. Proceedings of the National Academy of Sciences of the United States of America. PMID 29042514 DOI: 10.1073/Pnas.1707151114  1
2017 Whyte LS, Hemsley KM, Lau AA, Hassiotis S, Saito T, Saido TC, Hopwood JJ, Sargeant TJ. Reduction in open field activity in the absence of memory deficits in the App(NL-G-F) knock-in mouse model of Alzheimer's disease. Behavioural Brain Research. PMID 28887197 DOI: 10.1016/j.bbr.2017.09.006  1
2017 Wang H, Williams D, Griffin J, Saito T, Saido TC, Fraser PE, Rogaeva E, Schmitt-Ulms G. Time-course global proteome analyses reveal an inverse correlation between Aβ burden and immunoglobulin M levels in the APPNL-F mouse model of Alzheimer disease. Plos One. 12: e0182844. PMID 28832675 DOI: 10.1371/Journal.Pone.0182844  1
2017 Sasaguri H, Nilsson P, Hashimoto S, Nagata K, Saito T, De Strooper B, Hardy J, Vassar R, Winblad B, Saido TC. APP mouse models for Alzheimer's disease preclinical studies. The Embo Journal. PMID 28768718 DOI: 10.15252/Embj.201797397  1
2017 Szaruga M, Munteanu B, Lismont S, Veugelen S, Horré K, Mercken M, Saido TC, Ryan NS, De Vos T, Savvides SN, Gallardo R, Schymkowitz J, Rousseau F, Fox NC, Hopf C, et al. Alzheimer's-Causing Mutations Shift Aβ Length by Destabilizing γ-Secretase-Aβn Interactions. Cell. 170: 443-456.e14. PMID 28753424 DOI: 10.1016/J.Cell.2017.07.004  1
2017 Nakazono T, Lam TN, Patel AY, Kitazawa M, Saito T, Saido TC, Igarashi KM. Impaired In Vivo Gamma Oscillations in the Medial Entorhinal Cortex of Knock-in Alzheimer Model. Frontiers in Systems Neuroscience. 11: 48. PMID 28713250 DOI: 10.3389/Fnsys.2017.00048  1
2017 Batiuk MY, de Vin F, Duqué SI, Li C, Saito T, Saido T, Fiers M, Belgard TG, Holt MG. An Immunoaffinity-Based Method for Isolating Ultrapure Adult Astrocytes Based on ATP1B2 Targetting by the ACSA-2 Antibody. The Journal of Biological Chemistry. PMID 28373281 DOI: 10.1074/Jbc.M116.765313  1
2017 Guix FX, Sannerud R, Berditchevski F, Arranz AM, Horré K, Snellinx A, Thathiah A, Saido T, Saito T, Rajesh S, Overduin M, Kumar-Singh S, Radaelli E, Corthout N, Colombelli J, et al. Tetraspanin 6: a pivotal protein of the multiple vesicular body determining exosome release and lysosomal degradation of amyloid precursor protein fragments. Molecular Neurodegeneration. 12: 25. PMID 28279219 DOI: 10.1186/S13024-017-0165-0  1
2017 Fazzari P, Horre K, Arranz AM, Frigerio CS, Saito T, Saido TC, De Strooper B. PLD3 gene and processing of APP. Nature. 541: E1-E2. PMID 28128235 DOI: 10.1038/Nature21030  1
2016 Ono Y, Saido TC, Sorimachi H. Calpain research for drug discovery: challenges and potential. Nature Reviews. Drug Discovery. PMID 27833121 DOI: 10.1038/nrd.2016.212  1
2016 Saito T, Matsuba Y, Yamazaki N, Hashimoto S, Saido TC. Calpain Activation in Alzheimer's Model Mice Is an Artifact of APP and Presenilin Overexpression. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 36: 9933-6. PMID 27656030 DOI: 10.1523/JNEUROSCI.1907-16.2016  1
2016 Fujita K, Motoki K, Tagawa K, Chen X, Hama H, Nakajima K, Homma H, Tamura T, Watanabe H, Katsuno M, Matsumi C, Kajikawa M, Saito T, Saido T, Sobue G, et al. HMGB1, a pathogenic molecule that induces neurite degeneration via TLR4-MARCKS, is a potential therapeutic target for Alzheimer's disease. Scientific Reports. 6: 31895. PMID 27557632 DOI: 10.1038/Srep31895  1
2016 Masuda A, Kobayashi Y, Kogo N, Saito T, Saido TC, Itohara S. Cognitive deficits in single App knock-in mouse models. Neurobiology of Learning and Memory. PMID 27377630 DOI: 10.1016/J.Nlm.2016.07.001  1
2016 Veugelen S, Saito T, Saido TC, Chávez-Gutiérrez L, De Strooper B. Familial Alzheimer's Disease Mutations in Presenilin Generate Amyloidogenic Aβ Peptide Seeds. Neuron. 90: 410-6. PMID 27100199 DOI: 10.1016/j.neuron.2016.03.010  1
2016 Howatt DA, Balakrishnan A, Moorleghen JJ, Muniappan L, Rateri DL, Uchida HA, Takano J, Saido TC, Chishti AH, Baud L, Subramanian V. Leukocyte Calpain Deficiency Reduces Angiotensin II-Induced Inflammation and Atherosclerosis But Not Abdominal Aortic Aneurysms in Mice. Arteriosclerosis, Thrombosis, and Vascular Biology. PMID 26966280 DOI: 10.1161/ATVBAHA.116.307285  1
2016 Nagata K, Kiryu-Seo S, Tamada H, Okuyama-Uchimura F, Kiyama H, Saido TC. ECEL1 mutation implicates impaired axonal arborization of motor nerves in the pathogenesis of distal arthrogryposis. Acta Neuropathologica. PMID 26951213 DOI: 10.1007/S00401-016-1554-0  1
2016 Tanaka T, Nishiura Y, Araki R, Saido T, Abe R, Aoki S. 11B NMR Probes of Copper(II): Finding and Implications of the Cu2+-Promoted Decomposition of ortho-Carborane Derivatives European Journal of Inorganic Chemistry. 2016: 1819-1834. DOI: 10.1002/ejic.201600117  1
2015 Huang Y, Skwarek-Maruszewska A, Horré K, Vandewyer E, Wolfs L, Snellinx A, Saito T, Radaelli E, Corthout N, Colombelli J, Lo AC, Van Aerschot L, Callaerts-Vegh Z, Trabzuni D, Bossers K, ... ... Saido TC, et al. Loss of GPR3 reduces the amyloid plaque burden and improves memory in Alzheimer's disease mouse models. Science Translational Medicine. 7: 309ra164. PMID 26468326 DOI: 10.1126/Scitranslmed.Aab3492  1
2015 Kizuka Y, Nakano M, Kitazume S, Saito T, Saido TC, Taniguchi N. Bisecting GlcNAc modification stabilizes BACE1 protein under oxidative stress conditions. The Biochemical Journal. PMID 26467158 DOI: 10.1042/BJ20150607  1
2015 Zhang H, Wu L, Pchitskaya E, Zakharova O, Saito T, Saido T, Bezprozvanny I. Neuronal Store-Operated Calcium Entry and Mushroom Spine Loss in Amyloid Precursor Protein Knock-In Mouse Model of Alzheimer's Disease. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 35: 13275-86. PMID 26424877 DOI: 10.1523/Jneurosci.1034-15.2015  1
2015 Hama H, Hioki H, Namiki K, Hoshida T, Kurokawa H, Ishidate F, Kaneko T, Akagi T, Saito T, Saido T, Miyawaki A. ScaleS: an optical clearing palette for biological imaging. Nature Neuroscience. 18: 1518-29. PMID 26368944 DOI: 10.1038/nn.4107  1
2015 Kovacs L, Han W, Rafikov R, Bagi Z, Offermanns S, Saido TC, Black SM, Su Y. Activation of Calpain-2 by Mediators in Pulmonary Vascular Remodeling of Pulmonary Arterial Hypertension. American Journal of Respiratory Cell and Molecular Biology. PMID 26248159 DOI: 10.1165/rcmb.2015-0151OC  1
2015 Nilsson P, Loganathan K, Sekiguchi M, Winblad B, Iwata N, Saido TC, Tjernberg LO. Loss of neprilysin alters protein expression in the brain of Alzheimer's disease model mice. Proteomics. 15: 3349-55. PMID 26194619 DOI: 10.1002/pmic.201400211  1
2015 Machado VM, Morte MI, Carreira BP, Azevedo MM, Takano J, Iwata N, Saido TC, Asmussen H, Horwitz AR, Carvalho CM, Araújo IM. Involvement of calpains in adult neurogenesis: implications for stroke. Frontiers in Cellular Neuroscience. 9: 22. PMID 25698931 DOI: 10.3389/Fncel.2015.00022  1
2015 Kizuka Y, Kitazume S, Fujinawa R, Saito T, Iwata N, Saido TC, Nakano M, Yamaguchi Y, Hashimoto Y, Staufenbiel M, Hatsuta H, Murayama S, Manya H, Endo T, Taniguchi N. An aberrant sugar modification of BACE1 blocks its lysosomal targeting in Alzheimer's disease. Embo Molecular Medicine. 7: 175-89. PMID 25592972 DOI: 10.15252/emmm.201404438  1
2015 Thal DR, Walter J, Saido TC, Fändrich M. Neuropathology and biochemistry of Aβ and its aggregates in Alzheimer's disease. Acta Neuropathologica. 129: 167-82. PMID 25534025 DOI: 10.1007/s00401-014-1375-y  1
2015 Nilsson P, Sekiguchi M, Akagi T, Izumi S, Komori T, Hui K, Sörgjerd K, Tanaka M, Saito T, Iwata N, Saido TC. Autophagy-related protein 7 deficiency in amyloid β (Aβ) precursor protein transgenic mice decreases Aβ in the multivesicular bodies and induces Aβ accumulation in the Golgi. The American Journal of Pathology. 185: 305-13. PMID 25433221 DOI: 10.1016/j.ajpath.2014.10.011  1
2014 Kudo-Sakamoto Y, Akazawa H, Ito K, Takano J, Yano M, Yabumoto C, Naito AT, Oka T, Lee JK, Sakata Y, Suzuki J, Saido TC, Komuro I. Calpain-dependent cleavage of N-cadherin is involved in the progression of post-myocardial infarction remodeling. The Journal of Biological Chemistry. 289: 19408-19. PMID 24891510 DOI: 10.1074/jbc.M114.567206  1
2014 Nilsson P, Saito T, Saido TC. New mouse model of Alzheimer's. Acs Chemical Neuroscience. 5: 499-502. PMID 24852598 DOI: 10.1021/cn500105p  1
2014 Saito T, Matsuba Y, Mihira N, Takano J, Nilsson P, Itohara S, Iwata N, Saido TC. Single App knock-in mouse models of Alzheimer's disease. Nature Neuroscience. 17: 661-3. PMID 24728269 DOI: 10.1038/nn.3697  1
2014 Nilsson P, Saido TC. Dual roles for autophagy: degradation and secretion of Alzheimer's disease Aβ peptide. Bioessays : News and Reviews in Molecular, Cellular and Developmental Biology. 36: 570-8. PMID 24711225 DOI: 10.1002/bies.201400002  1
2014 Diepenbroek M, Casadei N, Esmer H, Saido TC, Takano J, Kahle PJ, Nixon RA, Rao MV, Melki R, Pieri L, Helling S, Marcus K, Krueger R, Masliah E, Riess O, et al. Overexpression of the calpain-specific inhibitor calpastatin reduces human alpha-Synuclein processing, aggregation and synaptic impairment in [A30P]αSyn transgenic mice. Human Molecular Genetics. 23: 3975-89. PMID 24619358 DOI: 10.1093/Hmg/Ddu112  1
2014 Nose-Ishibashi K, Watahiki J, Yamada K, Maekawa M, Watanabe A, Yamamoto G, Enomoto A, Matsuba Y, Nampo T, Taguchi T, Ichikawa Y, Saido TC, Mishima K, Yamaguchi Y, Yoshikawa T, et al. Soft-diet feeding after weaning affects behavior in mice: Potential increase in vulnerability to mental disorders. Neuroscience. 263: 257-68. PMID 24444829 DOI: 10.1016/J.Neuroscience.2013.12.065  1
2014 Iwata A, Nagata K, Hatsuta H, Takuma H, Bundo M, Iwamoto K, Tamaoka A, Murayama S, Saido T, Tsuji S. Altered CpG methylation in sporadic Alzheimer's disease is associated with APP and MAPT dysregulation. Human Molecular Genetics. 23: 648-56. PMID 24101602 DOI: 10.1093/hmg/ddt451  1
2014 Saito T, Saido TC. Animal models of Alzheimer’s disease Folia Pharmacologica Japonica. 144: 250-252. DOI: 10.1254/fpj.144.250  1
2013 Funamoto S, Sasaki T, Ishihara S, Nobuhara M, Nakano M, Watanabe-Takahashi M, Saito T, Kakuda N, Miyasaka T, Nishikawa K, Saido TC, Ihara Y. Substrate ectodomain is critical for substrate preference and inhibition of γ-secretase. Nature Communications. 4: 2529. PMID 24108142 DOI: 10.1038/ncomms3529  1
2013 Nilsson P, Loganathan K, Sekiguchi M, Matsuba Y, Hui K, Tsubuki S, Tanaka M, Iwata N, Saito T, Saido TC. Aβ secretion and plaque formation depend on autophagy. Cell Reports. 5: 61-9. PMID 24095740 DOI: 10.1016/j.celrep.2013.08.042  1
2013 Maruyama M, Shimada H, Suhara T, Shinotoh H, Ji B, Maeda J, Zhang MR, Trojanowski JQ, Lee VM, Ono M, Masamoto K, Takano H, Sahara N, Iwata N, Okamura N, ... ... Saido TC, et al. Imaging of tau pathology in a tauopathy mouse model and in Alzheimer patients compared to normal controls. Neuron. 79: 1094-108. PMID 24050400 DOI: 10.1016/J.Neuron.2013.07.037  1
2013 Huang Z, Rose AH, Hoffmann FW, Hashimoto AS, Bertino P, Denk T, Takano J, Iwata N, Saido TC, Hoffmann PR. Calpastatin prevents NF-κB-mediated hyperactivation of macrophages and attenuates colitis. Journal of Immunology (Baltimore, Md. : 1950). 191: 3778-88. PMID 23986533 DOI: 10.4049/jimmunol.1300972  1
2013 Saido TC. Metabolism of amyloid β peptide and pathogenesis of Alzheimer's disease. Proceedings of the Japan Academy. Series B, Physical and Biological Sciences. 89: 321-39. PMID 23883611 DOI: DN/JST.JSTAGE/pjab/89.321  0.01
2013 Frost JL, Le KX, Cynis H, Ekpo E, Kleinschmidt M, Palmour RM, Ervin FR, Snigdha S, Cotman CW, Saido TC, Vassar RJ, St George-Hyslop P, Ikezu T, Schilling S, Demuth HU, et al. Pyroglutamate-3 amyloid-β deposition in the brains of humans, non-human primates, canines, and Alzheimer disease-like transgenic mouse models. The American Journal of Pathology. 183: 369-81. PMID 23747948 DOI: 10.1016/J.Ajpath.2013.05.005  1
2013 Hayakawa H, Nagai M, Kawanami A, Nakata Y, Nihira T, Ogino M, Takada M, Saido T, Takano J, Saegusa M, Mikami T, Hamada J, Nishiyama K, Mochizuki H, Mizuno Y. Loss of DARPP-32 and calbindin in multiple system atrophy. Journal of Neural Transmission (Vienna, Austria : 1996). 120: 1689-98. PMID 23715974 DOI: 10.1007/s00702-013-1039-4  1
2013 Sörgjerd KM, Zako T, Sakono M, Stirling PC, Leroux MR, Saito T, Nilsson P, Sekimoto M, Saido TC, Maeda M. Human prefoldin inhibits amyloid-β (Aβ) fibrillation and contributes to formation of nontoxic Aβ aggregates. Biochemistry. 52: 3532-42. PMID 23614719 DOI: 10.1021/bi301705c  1
2013 Iwata N, Sekiguchi M, Hattori Y, Takahashi A, Asai M, Ji B, Higuchi M, Staufenbiel M, Muramatsu S, Saido TC. Global brain delivery of neprilysin gene by intravascular administration of AAV vector in mice. Scientific Reports. 3: 1472. PMID 23503602 DOI: 10.1038/srep01472  1
2013 Hübener J, Weber JJ, Richter C, Honold L, Weiss A, Murad F, Breuer P, Wüllner U, Bellstedt P, Paquet-Durand F, Takano J, Saido TC, Riess O, Nguyen HP. Calpain-mediated ataxin-3 cleavage in the molecular pathogenesis of spinocerebellar ataxia type 3 (SCA3). Human Molecular Genetics. 22: 508-18. PMID 23100324 DOI: 10.1093/Hmg/Dds449  1
2013 Saido TC. Metabolism of amyloid β peptide and pathogenesis of Alzheimer's disease Proceedings of the Japan Academy Series B: Physical and Biological Sciences. 89: 321-339. DOI: 10.2183/pjab.89.321  1
2013 Okuzaki H, Kuwabara T, Funasaka K, Saido T. Humidity-sensitive polypyrrole films for electro-active polymer actuators Advanced Functional Materials. 23: 4400-4407. DOI: 10.1002/adfm.201203883  1
2012 Yamashita T, Hideyama T, Hachiga K, Teramoto S, Takano J, Iwata N, Saido TC, Kwak S. A role for calpain-dependent cleavage of TDP-43 in amyotrophic lateral sclerosis pathology. Nature Communications. 3: 1307. PMID 23250437 DOI: 10.1038/ncomms2303  1
2012 Kitazume S, Yoshihisa A, Yamaki T, Oikawa M, Tachida Y, Ogawa K, Imamaki R, Hagiwara Y, Kinoshita N, Takeishi Y, Furukawa K, Tomita N, Arai H, Iwata N, Saido T, et al. Soluble amyloid precursor protein 770 is released from inflamed endothelial cells and activated platelets: a novel biomarker for acute coronary syndrome. The Journal of Biological Chemistry. 287: 40817-25. PMID 23033480 DOI: 10.1074/jbc.M112.398578  1
2012 Shanab AY, Nakazawa T, Ryu M, Tanaka Y, Himori N, Taguchi K, Yasuda M, Watanabe R, Takano J, Saido T, Minegishi N, Miyata T, Abe T, Yamamoto M. Metabolic stress response implicated in diabetic retinopathy: the role of calpain, and the therapeutic impact of calpain inhibitor. Neurobiology of Disease. 48: 556-67. PMID 22967911 DOI: 10.1016/J.Nbd.2012.07.025  1
2012 Kakiya N, Saito T, Nilsson P, Matsuba Y, Tsubuki S, Takei N, Nawa H, Saido TC. Cell surface expression of the major amyloid-β peptide (Aβ)-degrading enzyme, neprilysin, depends on phosphorylation by mitogen-activated protein kinase/extracellular signal-regulated kinase kinase (MEK) and dephosphorylation by protein phosphatase 1a. The Journal of Biological Chemistry. 287: 29362-72. PMID 22767595 DOI: 10.1074/jbc.M112.340372  1
2012 Saido T, Leissring MA. Proteolytic degradation of amyloid β-protein. Cold Spring Harbor Perspectives in Medicine. 2: a006379. PMID 22675659 DOI: 10.1101/cshperspect.a006379  1
2012 Schoch KM, Evans HN, Brelsfoard JM, Madathil SK, Takano J, Saido TC, Saatman KE. Calpastatin overexpression limits calpain-mediated proteolysis and behavioral deficits following traumatic brain injury. Experimental Neurology. 236: 371-82. PMID 22572592 DOI: 10.1016/J.Expneurol.2012.04.022  1
2012 Schlenzig D, Rönicke R, Cynis H, Ludwig HH, Scheel E, Reymann K, Saido T, Hause G, Schilling S, Demuth HU. N-Terminal pyroglutamate formation of Aβ38 and Aβ40 enforces oligomer formation and potency to disrupt hippocampal long-term potentiation. Journal of Neurochemistry. 121: 774-84. PMID 22375951 DOI: 10.1111/j.1471-4159.2012.07707.x  1
2012 Abramowski D, Rabe S, Upadhaya AR, Reichwald J, Danner S, Staab D, Capetillo-Zarate E, Yamaguchi H, Saido TC, Wiederhold KH, Thal DR, Staufenbiel M. Transgenic expression of intraneuronal Aβ42 but not Aβ40 leads to cellular Aβ lesions, degeneration, and functional impairment without typical Alzheimer's disease pathology. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 32: 1273-83. PMID 22279212 DOI: 10.1523/Jneurosci.4586-11.2012  1
2012 Higuchi M, Iwata N, Matsuba Y, Takano J, Suemoto T, Maeda J, Ji B, Ono M, Staufenbiel M, Suhara T, Saido TC. Mechanistic involvement of the calpain-calpastatin system in Alzheimer neuropathology. Faseb Journal : Official Publication of the Federation of American Societies For Experimental Biology. 26: 1204-17. PMID 22173972 DOI: 10.1096/fj.11-187740  1
2012 Ryu M, Yasuda M, Shi D, Shanab AY, Watanabe R, Himori N, Omodaka K, Yokoyama Y, Takano J, Saido T, Nakazawa T. Critical role of calpain in axonal damage-induced retinal ganglion cell death. Journal of Neuroscience Research. 90: 802-15. PMID 22065590 DOI: 10.1002/jnr.22800  1
2011 Saido T. [Metabolism of APP and production of Abeta]. Nihon Rinsho. Japanese Journal of Clinical Medicine. 69: 41-7. PMID 22787751  1
2011 Yahata N, Asai M, Kitaoka S, Takahashi K, Asaka I, Hioki H, Kaneko T, Maruyama K, Saido TC, Nakahata T, Asada T, Yamanaka S, Iwata N, Inoue H. Anti-Aβ drug screening platform using human iPS cell-derived neurons for the treatment of Alzheimer's disease. Plos One. 6: e25788. PMID 21984949 DOI: 10.1371/journal.pone.0025788  1
2011 Takano J, Mihira N, Fujioka R, Hosoki E, Chishti AH, Saido TC. Vital role of the calpain-calpastatin system for placental-integrity-dependent embryonic survival. Molecular and Cellular Biology. 31: 4097-106. PMID 21791606 DOI: 10.1128/MCB.05189-11  1
2011 Asai M, Yagishita S, Iwata N, Saido TC, Ishiura S, Maruyama K. An alternative metabolic pathway of amyloid precursor protein C-terminal fragments via cathepsin B in a human neuroglioma model. Faseb Journal : Official Publication of the Federation of American Societies For Experimental Biology. 25: 3720-30. PMID 21746863 DOI: 10.1096/fj.11-182154  1
2011 Saito T, Suemoto T, Brouwers N, Sleegers K, Funamoto S, Mihira N, Matsuba Y, Yamada K, Nilsson P, Takano J, Nishimura M, Iwata N, Van Broeckhoven C, Ihara Y, Saido TC. Potent amyloidogenicity and pathogenicity of Aβ43. Nature Neuroscience. 14: 1023-32. PMID 21725313 DOI: 10.1038/nn.2858  1
2011 Maeda J, Zhang MR, Okauchi T, Ji B, Ono M, Hattori S, Kumata K, Iwata N, Saido TC, Trojanowski JQ, Lee VM, Staufenbiel M, Tomiyama T, Mori H, Fukumura T, et al. In vivo positron emission tomographic imaging of glial responses to amyloid-beta and tau pathologies in mouse models of Alzheimer's disease and related disorders. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 31: 4720-30. PMID 21430171 DOI: 10.1523/Jneurosci.3076-10.2011  1
2011 Gomes JR, Lobo AC, Melo CV, Inácio AR, Takano J, Iwata N, Saido TC, de Almeida LP, Wieloch T, Duarte CB. Cleavage of the vesicular GABA transporter under excitotoxic conditions is followed by accumulation of the truncated transporter in nonsynaptic sites. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 31: 4622-35. PMID 21430162 DOI: 10.1523/Jneurosci.3541-10.2011  1
2011 Sato K, Minegishi S, Takano J, Plattner F, Saito T, Asada A, Kawahara H, Iwata N, Saido TC, Hisanaga S. Calpastatin, an endogenous calpain-inhibitor protein, regulates the cleavage of the Cdk5 activator p35 to p25. Journal of Neurochemistry. 117: 504-15. PMID 21338355 DOI: 10.1111/j.1471-4159.2011.07222.x  1
2011 Zhang G, Thomas AL, Marshall AL, Kernan KA, Su Y, Zheng Y, Takano J, Saido TC, Eddy AA. Nicotinic acetylcholine receptor α1 promotes calpain-1 activation and macrophage inflammation in hypercholesterolemic nephropathy. Laboratory Investigation; a Journal of Technical Methods and Pathology. 91: 106-23. PMID 20661225 DOI: 10.1038/labinvest.2010.135  1
2010 Kitazume S, Tachida Y, Kato M, Yamaguchi Y, Honda T, Hashimoto Y, Wada Y, Saito T, Iwata N, Saido T, Taniguchi N. Brain endothelial cells produce amyloid {beta} from amyloid precursor protein 770 and preferentially secrete the O-glycosylated form. The Journal of Biological Chemistry. 285: 40097-103. PMID 20952385 DOI: 10.1074/jbc.M110.144626  1
2010 Asai M, Iwata N, Tomita T, Iwatsubo T, Ishiura S, Saido TC, Maruyama K. Efficient four-drug cocktail therapy targeting amyloid-β peptide for Alzheimer's disease. Journal of Neuroscience Research. 88: 3588-97. PMID 20890992 DOI: 10.1002/jnr.22503  1
2010 Attems J, Yamaguchi H, Saido TC, Thal DR. Capillary CAA and perivascular Aβ-deposition: two distinct features of Alzheimer's disease pathology. Journal of the Neurological Sciences. 299: 155-62. PMID 20850138 DOI: 10.1016/J.Jns.2010.08.030  1
2010 Thal DR, Papassotiropoulos A, Saido TC, Griffin WS, Mrak RE, Kölsch H, Del Tredici K, Attems J, Ghebremedhin E. Capillary cerebral amyloid angiopathy identifies a distinct APOE epsilon4-associated subtype of sporadic Alzheimer's disease. Acta Neuropathologica. 120: 169-83. PMID 20535486 DOI: 10.1007/S00401-010-0707-9  1
2010 Nilsson P, Iwata N, Muramatsu S, Tjernberg LO, Winblad B, Saido TC. Gene therapy in Alzheimer's disease - potential for disease modification. Journal of Cellular and Molecular Medicine. 14: 741-57. PMID 20158567 DOI: 10.1111/J.1582-4934.2010.01038.X  1
2009 Kokubo H, Kayed R, Glabe CG, Staufenbiel M, Saido TC, Iwata N, Yamaguchi H. Amyloid Beta annular protofibrils in cell processes and synapses accumulate with aging and Alzheimer-associated genetic modification. International Journal of Alzheimer's Disease. 2009. PMID 20798763 DOI: 10.4061/2009/689285  1
2009 Nishida Y, Ito S, Ohtsuki S, Yamamoto N, Takahashi T, Iwata N, Jishage K, Yamada H, Sasaguri H, Yokota S, Piao W, Tomimitsu H, Saido TC, Yanagisawa K, Terasaki T, et al. Depletion of vitamin E increases amyloid beta accumulation by decreasing its clearances from brain and blood in a mouse model of Alzheimer disease. The Journal of Biological Chemistry. 284: 33400-8. PMID 19679659 DOI: 10.1074/jbc.M109.054056  1
2009 Choi YS, Lee B, Cho HY, Reyes IB, Pu XA, Saido TC, Hoyt KR, Obrietan K. CREB is a key regulator of striatal vulnerability in chemical and genetic models of Huntington's disease. Neurobiology of Disease. 36: 259-68. PMID 19632326 DOI: 10.1016/J.Nbd.2009.07.014  1
2009 Gonçalves I, Nitulescu M, Saido TC, Dias N, Pedro LM, E Fernandes JF, Ares MP, Pörn-Ares I. Activation of calpain-1 in human carotid artery atherosclerotic lesions. Bmc Cardiovascular Disorders. 9: 26. PMID 19538725 DOI: 10.1186/1471-2261-9-26  1
2009 Fujiwara H, Tabuchi M, Yamaguchi T, Iwasaki K, Furukawa K, Sekiguchi K, Ikarashi Y, Kudo Y, Higuchi M, Saido TC, Maeda S, Takashima A, Hara M, Yaegashi N, Kase Y, et al. A traditional medicinal herb Paeonia suffruticosa and its active constituent 1,2,3,4,6-penta-O-galloyl-beta-D-glucopyranose have potent anti-aggregation effects on Alzheimer's amyloid beta proteins in vitro and in vivo. Journal of Neurochemistry. 109: 1648-57. PMID 19457098 DOI: 10.1111/j.1471-4159.2009.06069.x  1
2009 Adachi A, Kano F, Saido TC, Murata M. Visual screening and analysis for kinase-regulated membrane trafficking pathways that are involved in extensive beta-amyloid secretion. Genes to Cells : Devoted to Molecular & Cellular Mechanisms. 14: 355-69. PMID 19210549 DOI: 10.1111/j.1365-2443.2008.01274.x  1
2009 Suzuki T, Miyamoto H, Nakahari T, Inoue I, Suemoto T, Jiang B, Hirota Y, Itohara S, Saido TC, Tsumoto T, Sawamoto K, Hensch TK, Delgado-Escueta AV, Yamakawa K. Efhc1 deficiency causes spontaneous myoclonus and increased seizure susceptibility. Human Molecular Genetics. 18: 1099-109. PMID 19147686 DOI: 10.1093/Hmg/Ddp006  1
2009 Nakazawa T, Shimura M, Mourin R, Kondo M, Yokokura S, Saido TC, Nishida K, Endo S. Calpain-mediated degradation of G-substrate plays a critical role in retinal excitotoxicity for amacrine cells. Journal of Neuroscience Research. 87: 1412-23. PMID 19105197 DOI: 10.1002/jnr.21953  1
2008 Nakajima R, Takao K, Huang SM, Takano J, Iwata N, Miyakawa T, Saido TC. Comprehensive behavioral phenotyping of calpastatin-knockout mice. Molecular Brain. 1: 7. PMID 18803809 DOI: 10.1186/1756-6606-1-7  1
2008 Cynis H, Scheel E, Saido TC, Schilling S, Demuth HU. Amyloidogenic processing of amyloid precursor protein: evidence of a pivotal role of glutaminyl cyclase in generation of pyroglutamate-modified amyloid-beta. Biochemistry. 47: 7405-13. PMID 18570439 DOI: 10.1021/bi800250p  1
2008 Wang J, Ohno-Matsui K, Yoshida T, Kojima A, Shimada N, Nakahama K, Safranova O, Iwata N, Saido TC, Mochizuki M, Morita I. Altered function of factor I caused by amyloid beta: implication for pathogenesis of age-related macular degeneration from Drusen. Journal of Immunology (Baltimore, Md. : 1950). 181: 712-20. PMID 18566438  1
2008 Hirata-Fukae C, Li HF, Hoe HS, Gray AJ, Minami SS, Hamada K, Niikura T, Hua F, Tsukagoshi-Nagai H, Horikoshi-Sakuraba Y, Mughal M, Rebeck GW, LaFerla FM, Mattson MP, Iwata N, ... Saido TC, et al. Females exhibit more extensive amyloid, but not tau, pathology in an Alzheimer transgenic model. Brain Research. 1216: 92-103. PMID 18486110 DOI: 10.1016/J.Brainres.2008.03.079  1
2008 Iwata N, Higuchi M, Saido TC. [Therapeutic strategy by manipulating some protease activities for Alzheimer's disease]. Nihon Yakurigaku Zasshi. Folia Pharmacologica Japonica. 131: 320-5. PMID 18480559 DOI: JST.JSTAGE/fpj/131.320  1
2008 Vetrivel KS, Zhang X, Meckler X, Cheng H, Lee S, Gong P, Lopes KO, Chen Y, Iwata N, Yin KJ, Lee JM, Parent AT, Saido TC, Li YM, Sisodia SS, et al. Evidence that CD147 modulation of beta-amyloid (Abeta) levels is mediated by extracellular degradation of secreted Abeta. The Journal of Biological Chemistry. 283: 19489-98. PMID 18456655 DOI: 10.1074/Jbc.M801037200  1
2008 Tachida Y, Nakagawa K, Saito T, Saido TC, Honda T, Saito Y, Murayama S, Endo T, Sakaguchi G, Kato A, Kitazume S, Hashimoto Y. Interleukin-1 beta up-regulates TACE to enhance alpha-cleavage of APP in neurons: resulting decrease in Abeta production. Journal of Neurochemistry. 104: 1387-93. PMID 18021299 DOI: 10.1111/J.1471-4159.2007.05127.X  1
2008 Takami H, Saido T, Endo T, Noro T, Musashi T, Kawamura T. Overwinter mortality of young-of-the-year Ezo abalone in relation to seawater temperature on the north Pacific coast of Japan Marine Ecology Progress Series. 367: 203-212. DOI: 10.3354/meps07557  1
2008 Okuzaki H, Saido T, Suzuki H, Hara Y, Yan H. A biomorphic origami actuator fabricated by folding a conducting paper Journal of Physics: Conference Series. 127. DOI: 10.1088/1742-6596/127/1/012001  1
2007 Saido T. [Trends in mechanism-based studies on the treatment of Alzheimer's disease]. Nihon Ronen Igakkai Zasshi. Japanese Journal of Geriatrics. 44: 690-3. PMID 18200756  1
2007 Maeda J, Ji B, Irie T, Tomiyama T, Maruyama M, Okauchi T, Staufenbiel M, Iwata N, Ono M, Saido TC, Suzuki K, Mori H, Higuchi M, Suhara T. Longitudinal, quantitative assessment of amyloid, neuroinflammation, and anti-amyloid treatment in a living mouse model of Alzheimer's disease enabled by positron emission tomography. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 27: 10957-68. PMID 17928437 DOI: 10.1523/JNEUROSCI.0673-07.2007  1
2007 Wang J, Pignol B, Chabrier PE, Saido T, Lloyd R, Tang Y, Lenoir M, Puel JL. A novel dual inhibitor of calpains and lipid peroxidation (BN82270) rescues the cochlea from sound trauma. Neuropharmacology. 52: 1426-37. PMID 17449343 DOI: 10.1016/j.neuropharm.2007.02.007  1
2007 Yoshiyama Y, Higuchi M, Zhang B, Huang SM, Iwata N, Saido TC, Maeda J, Suhara T, Trojanowski JQ, Lee VM. Synapse loss and microglial activation precede tangles in a P301S tauopathy mouse model. Neuron. 53: 337-51. PMID 17270732 DOI: 10.1016/J.Neuron.2007.01.010  1
2007 Hori Y, Hashimoto T, Wakutani Y, Urakami K, Nakashima K, Condron MM, Tsubuki S, Saido TC, Teplow DB, Iwatsubo T. The Tottori (D7N) and English (H6R) familial Alzheimer disease mutations accelerate Abeta fibril formation without increasing protofibril formation. The Journal of Biological Chemistry. 282: 4916-23. PMID 17170111 DOI: 10.1074/Jbc.M608220200  1
2007 Asai M, Iwata N, Yoshikawa A, Aizaki Y, Ishiura S, Saido TC, Maruyama K. Berberine alters the processing of Alzheimer's amyloid precursor protein to decrease Abeta secretion. Biochemical and Biophysical Research Communications. 352: 498-502. PMID 17125739 DOI: 10.1016/j.bbrc.2006.11.043  1
2007 Kamei H, Saito T, Ozawa M, Fujita Y, Asada A, Bibb JA, Saido TC, Sorimachi H, Hisanaga S. Suppression of calpain-dependent cleavage of the CDK5 activator p35 to p25 by site-specific phosphorylation. The Journal of Biological Chemistry. 282: 1687-94. PMID 17121855 DOI: 10.1074/jbc.M610541200  1
2007 Wirths O, Weis J, Kayed R, Saido TC, Bayer TA. Age-dependent axonal degeneration in an Alzheimer mouse model. Neurobiology of Aging. 28: 1689-99. PMID 16963164 DOI: 10.1016/J.Neurobiolaging.2006.07.021  1
2007 Yoshiyama Y, Higuchi M, Zhang B, Huang SM, Iwata N, Saido TC, Maeda J, Suhara T, Trojanowski JQ, Lee VMY. Synapse Loss and Microglial Activation Precede Tangles in a P301S Tauopathy Mouse Model (DOI:10.1016/j.neuron.2007.01.010) Neuron. 54: 343-344. DOI: 10.1016/j.neuron.2007.03.022  1
2007 Leissring M, Saido TC. Aβ degradation Alzheimer's Disease: Advances in Genetics, Molecular and Cellular Biology. 157-178. DOI: 10.1007/978-0-387-35135-3_10  1
2006 Higuchi M, Saido TC, Suhara T. Animal models of tauopathies. Neuropathology : Official Journal of the Japanese Society of Neuropathology. 26: 491-7. PMID 17080730 DOI: 10.1111/j.1440-1789.2006.00685.x  1
2006 Cynis H, Schilling S, Bodnár M, Hoffmann T, Heiser U, Saido TC, Demuth HU. Inhibition of glutaminyl cyclase alters pyroglutamate formation in mammalian cells. Biochimica Et Biophysica Acta. 1764: 1618-25. PMID 17005457 DOI: 10.1016/j.bbapap.2006.08.003  1
2006 Araya R, Noguchi T, Yuhki M, Kitamura N, Higuchi M, Saido TC, Seki K, Itohara S, Kawano M, Tanemura K, Takashima A, Yamada K, Kondoh Y, Kanno I, Wess J, et al. Loss of M5 muscarinic acetylcholine receptors leads to cerebrovascular and neuronal abnormalities and cognitive deficits in mice. Neurobiology of Disease. 24: 334-44. PMID 16956767 DOI: 10.1016/J.Nbd.2006.07.010  1
2006 Sato T, Nyborg AC, Iwata N, Diehl TS, Saido TC, Golde TE, Wolfe MS. Signal peptide peptidase: biochemical properties and modulation by nonsteroidal antiinflammatory drugs. Biochemistry. 45: 8649-56. PMID 16834339 DOI: 10.1021/bi060597g  1
2006 Hattori C, Asai M, Onishi H, Sasagawa N, Hashimoto Y, Saido TC, Maruyama K, Mizutani S, Ishiura S. BACE1 interacts with lipid raft proteins. Journal of Neuroscience Research. 84: 912-7. PMID 16823808 DOI: 10.1002/jnr.20981  1
2006 Samura E, Shoji M, Kawarabayashi T, Sasaki A, Matsubara E, Murakami T, Wuhua X, Tamura S, Ikeda M, Ishiguro K, Saido TC, Westaway D, St George Hyslop P, Harigaya Y, Abe K. Enhanced accumulation of tau in doubly transgenic mice expressing mutant betaAPP and presenilin-1. Brain Research. 1094: 192-9. PMID 16713590 DOI: 10.1016/J.Brainres.2005.12.134  1
2006 Fujiwara H, Iwasaki K, Furukawa K, Seki T, He M, Maruyama M, Tomita N, Kudo Y, Higuchi M, Saido TC, Maeda S, Takashima A, Hara M, Ohizumi Y, Arai H. Uncaria rhynchophylla, a Chinese medicinal herb, has potent antiaggregation effects on Alzheimer's beta-amyloid proteins. Journal of Neuroscience Research. 84: 427-33. PMID 16676329 DOI: 10.1002/jnr.20891  1
2006 Huang SM, Mouri A, Kokubo H, Nakajima R, Suemoto T, Higuchi M, Staufenbiel M, Noda Y, Yamaguchi H, Nabeshima T, Saido TC, Iwata N. Neprilysin-sensitive synapse-associated amyloid-beta peptide oligomers impair neuronal plasticity and cognitive function. The Journal of Biological Chemistry. 281: 17941-51. PMID 16636059 DOI: 10.1074/jbc.M601372200  1
2006 Saido TC, Iwata N. Metabolism of amyloid beta peptide and pathogenesis of Alzheimer's disease. Towards presymptomatic diagnosis, prevention and therapy. Neuroscience Research. 54: 235-53. PMID 16457902 DOI: 10.1016/j.neures.2005.12.015  1
2006 Nakagawa K, Kitazume S, Oka R, Maruyama K, Saido TC, Sato Y, Endo T, Hashimoto Y. Sialylation enhances the secretion of neurotoxic amyloid-beta peptides. Journal of Neurochemistry. 96: 924-33. PMID 16412100 DOI: 10.1111/j.1471-4159.2005.03595.x  1
2006 Zou LB, Mouri A, Iwata N, Saido TC, Wang D, Wang MW, Mizoguchi H, Noda Y, Nabeshima T. Inhibition of neprilysin by infusion of thiorphan into the hippocampus causes an accumulation of amyloid Beta and impairment of learning and memory. The Journal of Pharmacology and Experimental Therapeutics. 317: 334-40. PMID 16382024 DOI: 10.1124/jpet.105.095687  1
2006 Mouri A, Zou LB, Iwata N, Saido TC, Wang D, Wang MW, Noda Y, Nabeshima T. Inhibition of neprilysin by thiorphan (i.c.v.) causes an accumulation of amyloid beta and impairment of learning and memory. Behavioural Brain Research. 168: 83-91. PMID 16360221 DOI: 10.1016/j.bbr.2005.10.014  1
2006 Asai M, Hattori C, Iwata N, Saido TC, Sasagawa N, Szabó B, Hashimoto Y, Maruyama K, Tanuma S, Kiso Y, Ishiura S. The novel beta-secretase inhibitor KMI-429 reduces amyloid beta peptide production in amyloid precursor protein transgenic and wild-type mice. Journal of Neurochemistry. 96: 533-40. PMID 16336629 DOI: 10.1111/j.1471-4159.2005.03576.x  1
2006 Harigaya Y, Tomidokoro Y, Ikeda M, Sasaki A, Kawarabayashi T, Matsubara E, Kanai M, Saido TC, Younkin SG, Shoji M. Type-specific evolution of amyloid plaque and angiopathy in APPsw mice. Neuroscience Letters. 395: 37-41. PMID 16298484 DOI: 10.1016/J.Neulet.2005.10.087  1
2005 Iwata N, Saido TC, Mizukami H, Ozawa K. [Experimental gene therapy for Alzheimer's disease--animal models]. Nihon Rinsho. Japanese Journal of Clinical Medicine. 63: 691-8. PMID 16416874  1
2005 Iwata N, Higuchi M, Saito T, Saido TC. [Presymptomatic diagnosis, prevention and therapy]. Nå to Shinkei = Brain and Nerve. 57: 855-66. PMID 16277230  1
2005 Ogawa T, Kiryu-Seo S, Tanaka M, Konishi H, Iwata N, Saido T, Watanabe Y, Kiyama H. Altered expression of neprilysin family members in the pituitary gland of sleep-disturbed rats, an animal model of severe fatigue. Journal of Neurochemistry. 95: 1156-66. PMID 16271049 DOI: 10.1111/J.1471-4159.2005.03436.X  1
2005 Thal DR, Capetillo-Zarate E, Schultz C, Rüb U, Saido TC, Yamaguchi H, Haass C, Griffin WS, Del Tredici K, Braak H, Ghebremedhin E. Apolipoprotein E co-localizes with newly formed amyloid beta-protein (Abeta) deposits lacking immunoreactivity against N-terminal epitopes of Abeta in a genotype-dependent manner. Acta Neuropathologica. 110: 459-71. PMID 16195918 DOI: 10.1007/S00401-005-1053-1  1
2005 Yoshida T, Ohno-Matsui K, Ichinose S, Sato T, Iwata N, Saido TC, Hisatomi T, Mochizuki M, Morita I. The potential role of amyloid beta in the pathogenesis of age-related macular degeneration. The Journal of Clinical Investigation. 115: 2793-800. PMID 16167083 DOI: 10.1172/JCI24635  1
2005 Iwata N, Higuchi M, Saido TC. Metabolism of amyloid-beta peptide and Alzheimer's disease. Pharmacology & Therapeutics. 108: 129-48. PMID 16112736 DOI: 10.1016/j.pharmthera.2005.03.010  1
2005 Piccini A, Russo C, Gliozzi A, Relini A, Vitali A, Borghi R, Giliberto L, Armirotti A, D'Arrigo C, Bachi A, Cattaneo A, Canale C, Torrassa S, Saido TC, Markesbery W, et al. beta-amyloid is different in normal aging and in Alzheimer disease. The Journal of Biological Chemistry. 280: 34186-92. PMID 16103127 DOI: 10.1074/Jbc.M501694200  1
2005 Higuchi M, Iwata N, Saido TC. Understanding molecular mechanisms of proteolysis in Alzheimer's disease: progress toward therapeutic interventions. Biochimica Et Biophysica Acta. 1751: 60-7. PMID 16054018 DOI: 10.1016/j.bbapap.2005.02.013  1
2005 Maruyama M, Higuchi M, Takaki Y, Matsuba Y, Tanji H, Nemoto M, Tomita N, Matsui T, Iwata N, Mizukami H, Muramatsu S, Ozawa K, Saido TC, Arai H, Sasaki H. Cerebrospinal fluid neprilysin is reduced in prodromal Alzheimer's disease. Annals of Neurology. 57: 832-42. PMID 15929037 DOI: 10.1002/ana.20494  1
2005 Hama E, Saido TC. Etiology of sporadic Alzheimer's disease: somatostatin, neprilysin, and amyloid beta peptide. Medical Hypotheses. 65: 498-500. PMID 15921860 DOI: 10.1016/j.mehy.2005.02.045  1
2005 Kokubo H, Kayed R, Glabe CG, Saido TC, Iwata N, Helms JB, Yamaguchi H. Oligomeric proteins ultrastructurally localize to cell processes, especially to axon terminals with higher density, but not to lipid rafts in Tg2576 mouse brain. Brain Research. 1045: 224-8. PMID 15910781 DOI: 10.1016/J.Brainres.2005.03.017  1
2005 Sato T, Tanimura Y, Hirotani N, Saido TC, Morishima-Kawashima M, Ihara Y. Blocking the cleavage at midportion between gamma- and epsilon-sites remarkably suppresses the generation of amyloid beta-protein. Febs Letters. 579: 2907-12. PMID 15890346 DOI: 10.1016/j.febslet.2005.04.037  1
2005 Hayashi M, Koshihara Y, Ishibashi H, Yamamoto S, Tsubuki S, Saido TC, Kawashima S, Inomata M. Involvement of calpain in osteoclastic bone resorption. Journal of Biochemistry. 137: 331-8. PMID 15809334 DOI: 10.1093/jb/mvi036  1
2005 Kambe A, Yokota M, Saido TC, Satokata I, Fujikawa H, Tabuchi S, Kamitani H, Watanabe T. Spatial resolution of calpain-catalyzed proteolysis in focal cerebral ischemia. Brain Research. 1040: 36-43. PMID 15804424 DOI: 10.1016/j.brainres.2005.01.080  1
2005 Saito T, Iwata N, Tsubuki S, Takaki Y, Takano J, Huang SM, Suemoto T, Higuchi M, Saido TC. Somatostatin regulates brain amyloid beta peptide Abeta42 through modulation of proteolytic degradation. Nature Medicine. 11: 434-9. PMID 15778722 DOI: 10.1038/nm1206  1
2005 Iwata N, Ozawa K, Saido TC. [Gene therapy for Alzheimer' s disease]. Nihon Rinsho. Japanese Journal of Clinical Medicine. 63: 394-400. PMID 15773336  1
2005 Higuchi M, Iwata N, Matsuba Y, Sato K, Sasamoto K, Saido TC. 19F and 1H MRI detection of amyloid beta plaques in vivo. Nature Neuroscience. 8: 527-33. PMID 15768036 DOI: 10.1038/nn1422  1
2005 Konishi T, Yoshiyama Y, Takomori M, Saido T. Long-term treatment of generalised myasthenia gravis with FK506 (tacrolimus) Journal of Neurology, Neurosurgery and Psychiatry. 76: 448-450. PMID 15716549 DOI: 10.1136/jnnp.2004.042176  1
2005 Higuchi M, Tomioka M, Takano J, Shirotani K, Iwata N, Masumoto H, Maki M, Itohara S, Saido TC. Distinct mechanistic roles of calpain and caspase activation in neurodegeneration as revealed in mice overexpressing their specific inhibitors. The Journal of Biological Chemistry. 280: 15229-37. PMID 15699033 DOI: 10.1074/jbc.M500939200  1
2005 Shin RW, Saido TC, Maeda M, Kitamoto T. Novel alpha-secretase cleavage of Alzheimer's amyloid beta precursor protein in the endoplasmic reticulum of COS7 cells. Neuroscience Letters. 376: 14-9. PMID 15694266 DOI: 10.1016/j.neulet.2004.11.032  1
2005 Takano J, Tomioka M, Tsubuki S, Higuchi M, Iwata N, Itohara S, Maki M, Saido TC. Calpain mediates excitotoxic DNA fragmentation via mitochondrial pathways in adult brains: evidence from calpastatin mutant mice. The Journal of Biological Chemistry. 280: 16175-84. PMID 15691848 DOI: 10.1074/jbc.M414552200  1
2005 Kokubo H, Saido TC, Iwata N, Helms JB, Shinohara R, Yamaguchi H. Part of membrane-bound Abeta exists in rafts within senile plaques in Tg2576 mouse brain. Neurobiology of Aging. 26: 409-18. PMID 15653169 DOI: 10.1016/j.neurobiolaging.2004.04.008  1
2005 Qi-Takahara Y, Morishima-Kawashima M, Tanimura Y, Dolios G, Hirotani N, Horikoshi Y, Kametani F, Maeda M, Saido TC, Wang R, Ihara Y. Longer forms of amyloid beta protein: implications for the mechanism of intramembrane cleavage by gamma-secretase. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 25: 436-45. PMID 15647487 DOI: 10.1523/JNEUROSCI.1575-04.2005  1
2005 Bialkowska K, Saido TC, Fox JE. SH3 domain of spectrin participates in the activation of Rac in specialized calpain-induced integrin signaling complexes. Journal of Cell Science. 118: 381-95. PMID 15632109 DOI: 10.1242/jcs.01625  1
2005 Okuzaki H, Saido T. Electro-driven polypyrrole actuators working in air Proceedings of Spie - the International Society For Optical Engineering. 5759: 379-387. DOI: 10.1117/12.599295  1
2005 Sekino M, Saido T, Fujita T, Kobayashi T, Takami H. Microsatellite DNA markers of Ezo abalone (Haliotis discus hannai): A preliminary assessment of natural populations sampled from heavily stocked areas Aquaculture. 243: 33-47. DOI: 10.1016/j.aquaculture.2004.10.013  1
2005 Saido T, Okuzaki H. Conducting paper actuators [II] - Effect of heat treatment on structure and electromechanical properties Polymer Preprints, Japan. 54: 1447.  1
2005 Suzuki H, Harashina Y, Fujita H, Endo S, Saido T, Okuzaki H. Thermal stability and electrical and mechanical properties of PEDOT/PSS Polymer Preprints, Japan. 54: 4149.  1
2005 Saido T, Okuzaki H. Conducting paper actuators [III] - Effect of humidity on elongation and contraction under electric field Polymer Preprints, Japan. 54: 4579-4580.  1
2004 Saido TC. [Towards presymptomatic diagnosis, prevention and treatment of Alzheimer's disease]. Rinshå Shinkeigaku = Clinical Neurology. 44: 775-7. PMID 15651288  1
2004 Kitazume S, Kotani N, Nakato H, Saido T, Hashimoto Y. [Glycosyltransferases as substrates for Alzheimer's beta-secretase]. Tanpakushitsu Kakusan Koso. Protein, Nucleic Acid, Enzyme. 49: 2468-72. PMID 15553003  1
2004 Funamoto S, Morishima-Kawashima M, Tanimura Y, Hirotani N, Saido TC, Ihara Y. Truncated carboxyl-terminal fragments of beta-amyloid precursor protein are processed to amyloid beta-proteins 40 and 42. Biochemistry. 43: 13532-40. PMID 15491160 DOI: 10.1021/bi049399k  1
2004 Kitazume S, Suzuki M, Saido TC, Hashimoto Y. Involvement of proteases in glycosyltransferase secretion: Alzheimer's beta-secretase-dependent cleavage and a following processing by an aminopeptidase. Glycoconjugate Journal. 21: 25-9. PMID 15467394 DOI: 10.1023/B:GLYC.0000043743.21735.ff  1
2004 Ladrech S, Guitton M, Saido T, Lenoir M. Calpain activity in the amikacin-damaged rat cochlea. The Journal of Comparative Neurology. 477: 149-60. PMID 15300786 DOI: 10.1002/cne.20252  1
2004 Sato K, Higuchi M, Iwata N, Saido TC, Sasamoto K. Fluoro-substituted and 13C-labeled styrylbenzene derivatives for detecting brain amyloid plaques. European Journal of Medicinal Chemistry. 39: 573-8. PMID 15236837 DOI: 10.1016/j.ejmech.2004.02.013  1
2004 Wakutani Y, Watanabe K, Adachi Y, Wada-Isoe K, Urakami K, Ninomiya H, Saido TC, Hashimoto T, Iwatsubo T, Nakashima K. Novel amyloid precursor protein gene missense mutation (D678N) in probable familial Alzheimer's disease. Journal of Neurology, Neurosurgery, and Psychiatry. 75: 1039-42. PMID 15201367 DOI: 10.1136/jnnp.2003.010611  1
2004 Hama E, Shirotani K, Iwata N, Saido TC. Effects of neprilysin chimeric proteins targeted to subcellular compartments on amyloid beta peptide clearance in primary neurons. The Journal of Biological Chemistry. 279: 30259-64. PMID 15100223 DOI: 10.1074/jbc.M401891200  1
2004 Kimura T, Shuto D, Kasai S, Liu P, Hidaka K, Hamada T, Hayashi Y, Hattori C, Asai M, Kitazume S, Saido TC, Ishiura S, Kiso Y. KMI-358 and KMI-370, highly potent and small-sized BACE1 inhibitors containing phenylnorstatine. Bioorganic & Medicinal Chemistry Letters. 14: 1527-31. PMID 15006396 DOI: 10.1016/j.bmcl.2003.12.088  1
2004 Kitazume S, Saido TC, Hashimoto Y. Alzheimer's beta-secretase cleaves a glycosyltransferase as a physiological substrate. Glycoconjugate Journal. 20: 59-62. PMID 14973371 DOI: 10.1023/B:GLYC.0000016743.25495.45  1
2004 Iwata N, Mizukami H, Shirotani K, Takaki Y, Muramatsu S, Lu B, Gerard NP, Gerard C, Ozawa K, Saido TC. Presynaptic localization of neprilysin contributes to efficient clearance of amyloid-beta peptide in mouse brain. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 24: 991-8. PMID 14749444 DOI: 10.1523/Jneurosci.4792-03.2004  1
2003 Inoue H, Tsukita K, Iwasato T, Suzuki Y, Tomioka M, Tateno M, Nagao M, Kawata A, Saido TC, Miura M, Misawa H, Itohara S, Takahashi R. The crucial role of caspase-9 in the disease progression of a transgenic ALS mouse model. The Embo Journal. 22: 6665-74. PMID 14657037 DOI: 10.1093/Emboj/Cdg634  1
2003 Rami A, Volkmann T, Agarwal R, Schoninger S, Nürnberger F, Saido TC, Winckler J. beta2-Adrenergic receptor responsiveness of the calpain-calpastatin system and attenuation of neuronal death in rat hippocampus after transient global ischemia. Neuroscience Research. 47: 373-82. PMID 14630341  1
2003 Yamashima T, Tonchev AB, Tsukada T, Saido TC, Imajoh-Ohmi S, Momoi T, Kominami E. Sustained calpain activation associated with lysosomal rupture executes necrosis of the postischemic CA1 neurons in primates. Hippocampus. 13: 791-800. PMID 14620874 DOI: 10.1002/hipo.10127  1
2003 Wang DS, Iwata N, Hama E, Saido TC, Dickson DW. Oxidized neprilysin in aging and Alzheimer's disease brains. Biochemical and Biophysical Research Communications. 310: 236-41. PMID 14511676 DOI: 10.1016/J.Bbrc.2003.09.003  1
2003 Yokota M, Saido TC, Kamitani H, Tabuchi S, Satokata I, Watanabe T. Calpain induces proteolysis of neuronal cytoskeleton in ischemic gerbil forebrain. Brain Research. 984: 122-32. PMID 12932846 DOI: 10.1016/S0006-8993(03)03121-4  1
2003 Saito T, Takaki Y, Iwata N, Trojanowski J, Saido TC. Alzheimer's disease, neuropeptides, neuropeptidase, and amyloid-beta peptide metabolism. Science of Aging Knowledge Environment : Sage Ke. 2003: PE1. PMID 12844556 DOI: 10.1126/Sageke.2003.3.Pe1  1
2003 Iwata N, Saido TC. [Amyloid-beta peptide metabolism and Alzheimer's disease]. Nihon Yakurigaku Zasshi. Folia Pharmacologica Japonica. 122: 5-14. PMID 12843567 DOI: 10.1254/fpj.122.5  1
2003 Kitazume-Kawaguchi S, Hashimoto Y, Saido T. [BACE1 and glycosyltransferases]. Tanpakushitsu Kakusan Koso. Protein, Nucleic Acid, Enzyme. 48: 984-9. PMID 12806999  1
2003 Tsubuki S, Takaki Y, Saido TC. Dutch, Flemish, Italian, and Arctic mutations of APP and resistance of Abeta to physiologically relevant proteolytic degradation. Lancet. 361: 1957-8. PMID 12801742 DOI: 10.1016/S0140-6736(03)13555-6  1
2003 Pörn-Ares MI, Saido TC, Andersson T, Ares MP. Oxidized low-density lipoprotein induces calpain-dependent cell death and ubiquitination of caspase 3 in HMEC-1 endothelial cells. The Biochemical Journal. 374: 403-11. PMID 12775216 DOI: 10.1042/Bj20021955  1
2003 Zhang J, Miyamoto K, Hashioka S, Hao HP, Murao K, Saido TC, Nakanishi H. Activation of mu-calpain in developing cortical neurons following methylmercury treatment. Brain Research. Developmental Brain Research. 142: 105-10. PMID 12694949 DOI: 10.1016/S0165-3806(03)00057-9  1
2003 Kitazume S, Tachida Y, Oka R, Kotani N, Ogawa K, Suzuki M, Dohmae N, Takio K, Saido TC, Hashimoto Y. Characterization of alpha 2,6-sialyltransferase cleavage by Alzheimer's beta -secretase (BACE1). The Journal of Biological Chemistry. 278: 14865-71. PMID 12473667 DOI: 10.1074/jbc.M206262200  1
2003 Rami A, Volkmann T, Agarwal R, Schoninger S, Nürnberger F, Saido TC, Winckler J. β2-Adrenergic receptor responsiveness of the calpain-calpastatin system and attenuation of neuronal death in rat hippocampus after transient global ischemia Neuroscience Research. 47: 373-382. DOI: 10.1016/j.neures.2003.07.002  1
2002 Tomioka M, Shirotani K, Iwata N, Lee HJ, Yang F, Cole GM, Seyama Y, Saido TC. In vivo role of caspases in excitotoxic neuronal death: generation and analysis of transgenic mice expressing baculoviral caspase inhibitor, p35, in postnatal neurons. Brain Research. Molecular Brain Research. 108: 18-32. PMID 12480175 DOI: 10.1016/S0169-328X(02)00486-2  1
2002 Mori C, Spooner ET, Wisniewsk KE, Wisniewski TM, Yamaguch H, Saido TC, Tolan DR, Selkoe DJ, Lemere CA. Intraneuronal Abeta42 accumulation in Down syndrome brain. Amyloid : the International Journal of Experimental and Clinical Investigation : the Official Journal of the International Society of Amyloidosis. 9: 88-102. PMID 12440481  1
2002 Kuwako K, Nishimura I, Uetsuki T, Saido TC, Yoshikawa K. Activation of calpain in cultured neurons overexpressing Alzheimer amyloid precursor protein. Brain Research. Molecular Brain Research. 107: 166-75. PMID 12425945 DOI: 10.1016/S0169-328X(02)00489-8  1
2002 Kitazume S, Saido TC, Hashimoto Y. [Identification of a novel substrate of Alzheimer's beta-secretase: beta-secretase dependent cleavage of alpha 2,6 sialyltransferase]. Seikagaku. the Journal of Japanese Biochemical Society. 74: 1180-3. PMID 12402461  1
2002 Iwata N, Takaki Y, Fukami S, Tsubuki S, Saido TC. Region-specific reduction of A beta-degrading endopeptidase, neprilysin, in mouse hippocampus upon aging. Journal of Neuroscience Research. 70: 493-500. PMID 12391610 DOI: 10.1002/jnr.10390  1
2002 Takahashi M, Fukami S, Iwata N, Inoue K, Itohara S, Itoh H, Haraoka J, Saido T. In vivo glioma growth requires host-derived matrix metalloproteinase 2 for maintenance of angioarchitecture. Pharmacological Research : the Official Journal of the Italian Pharmacological Society. 46: 155-63. PMID 12220955 DOI: 10.1016/S1043-6618(02)00081-6  1
2002 Shirotani K, Tsubuki S, Lee HJ, Maruyama K, Saido TC. Generation of amyloid beta peptide with pyroglutamate at position 3 in primary cortical neurons. Neuroscience Letters. 327: 25-8. PMID 12098492 DOI: 10.1016/S0304-3940(02)00351-8  1
2002 Fukami S, Watanabe K, Iwata N, Haraoka J, Lu B, Gerard NP, Gerard C, Fraser P, Westaway D, St George-Hyslop P, Saido TC. Abeta-degrading endopeptidase, neprilysin, in mouse brain: synaptic and axonal localization inversely correlating with Abeta pathology. Neuroscience Research. 43: 39-56. PMID 12074840 DOI: 10.1016/S0168-0102(02)00015-9  1
2002 Hattori C, Asai M, Oma Y, Kino Y, Sasagawa N, Saido TC, Maruyama K, Ishiura S. BACE1 interacts with nicastrin. Biochemical and Biophysical Research Communications. 293: 1228-32. PMID 12054507 DOI: 10.1016/S0006-291X(02)00351-0  1
2002 Daré E, Tofighi R, Vettori MV, Momoi T, Poli D, Saido TC, Mutti A, Ceccatelli S. Styrene 7,8-oxide induces caspase activation and regular DNA fragmentation in neuronal cells. Brain Research. 933: 12-22. PMID 11929631 DOI: 10.1016/S0006-8993(02)02274-6  1
2002 Fukami S, Iwata N, Saido TC. Therapeutic strategies of Alzheimer's disease through manipulation of Aβ metabolism: A focus on Aβ-degrading peptidase, neprilysin Drug Development Research. 56: 171-183. DOI: 10.1002/ddr.10073  1
2001 Kim JE, Han BS, Choi WS, Eom DS, Lee EH, Oh TH, Markelonis GJ, Saido TC, Lee GE, Chung IK, Oh YJ. Temporospatial sequence of cellular events associated with etoposide-induced neuronal cell death: role of antiapoptotic protein Bcl-X(L). Journal of Neuroscience Research. 66: 1074-82. PMID 11746439 DOI: 10.1002/jnr.10028  1
2001 Kaneko T, Yamashima T, Tohma Y, Nomura M, Imajoh-Ohmi S, Saido TC, Nakao M, Saya H, Yamamoto H, Yamashita J. Calpain-dependent proteolysis of merlin occurs by oxidative stress in meningiomas: a novel hypothesis of tumorigenesis. Cancer. 92: 2662-72. PMID 11745202 DOI: 10.1002/1097-0142(20011115)92:10<2662::AID-CNCR1620>3.0.CO;2-9  1
2001 Hama E, Shirotani K, Masumoto H, Sekine-Aizawa Y, Aizawa H, Saido TC. Clearance of extracellular and cell-associated amyloid beta peptide through viral expression of neprilysin in primary neurons. Journal of Biochemistry. 130: 721-6. PMID 11726269  1
2001 Kitazume S, Tachida Y, Oka R, Shirotani K, Saido TC, Hashimoto Y. Alzheimer's beta-secretase, beta-site amyloid precursor protein-cleaving enzyme, is responsible for cleavage secretion of a Golgi-resident sialyltransferase. Proceedings of the National Academy of Sciences of the United States of America. 98: 13554-9. PMID 11698669 DOI: 10.1073/pnas.241509198  1
2001 Morishima-Kawashima M, Saido TC, Ihara Y. [Alzheimer's disease and the proteins]. Tanpakushitsu Kakusan Koso. Protein, Nucleic Acid, Enzyme. 46: 1798-804. PMID 11579581  1
2001 Russo C, Schettini G, Saido TC, Gambetti P, Tabaton M, Teller JT, Larner AJ. N-terminal truncated amyloid β-peptides and Alzheimer's disease (multiple letters) Neurobiology of Aging. 22: 343-345. PMID 11414252 DOI: 10.1016/S0197-4580(01)00212-3  1
2001 Choi WS, Lee EH, Chung CW, Jung YK, Jin BK, Kim SU, Oh TH, Saido TC, Oh YJ. Cleavage of Bax is mediated by caspase-dependent or -independent calpain activation in dopaminergic neuronal cells: protective role of Bcl-2. Journal of Neurochemistry. 77: 1531-41. PMID 11413236 DOI: 10.1046/j.1471-4159.2001.00368.x  1
2001 Iwata N, Tsubuki S, Takaki Y, Shirotani K, Lu B, Gerard NP, Gerard C, Hama E, Lee HJ, Saido TC. Metabolic regulation of brain Abeta by neprilysin. Science (New York, N.Y.). 292: 1550-2. PMID 11375493 DOI: 10.1126/Science.1059946  1
2001 Shirotani K, Tsubuki S, Iwata N, Takaki Y, Harigaya W, Maruyama K, Kiryu-Seo S, Kiyama H, Iwata H, Tomita T, Iwatsubo T, Saido TC. Neprilysin degrades both amyloid beta peptides 1-40 and 1-42 most rapidly and efficiently among thiorphan- and phosphoramidon-sensitive endopeptidases. The Journal of Biological Chemistry. 276: 21895-901. PMID 11278416 DOI: 10.1074/Jbc.M008511200  1
2001 Sekine-Aizawa Y, Hama E, Watanabe K, Tsubuki S, Kanai-Azuma M, Kanai Y, Arai H, Aizawa H, Iwata N, Saido TC. Matrix metalloproteinase (MMP) system in brain: identification and characterization of brain-specific MMP highly expressed in cerebellum. The European Journal of Neuroscience. 13: 935-48. PMID 11264666 DOI: 10.1046/j.0953-816X.2001.01462.x  0.36
2001 Taniguchi S, Fujita Y, Hayashi S, Kakita A, Takahashi H, Murayama S, Saido TC, Hisanaga S, Iwatsubo T, Hasegawa M. Calpain-mediated degradation of p35 to p25 in postmortem human and rat brains. Febs Letters. 489: 46-50. PMID 11231011 DOI: 10.1016/S0014-5793(00)02431-5  1
2001 Kawarabayashi T, Younkin LH, Saido TC, Shoji M, Ashe KH, Younkin SG. Age-dependent changes in brain, CSF, and plasma amyloid (beta) protein in the Tg2576 transgenic mouse model of Alzheimer's disease. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 21: 372-81. PMID 11160418  1
2000 Koike H, Kouchi Z, Kinouchi T, Maeda T, Sorimachi H, Saido TC, Maruyama K, Okuyama A, Suzuki K, Ishiura S. Metabolism of amyloid precursor protein in COS cells transfected with a beta-secretase candidate. Cytotechnology. 33: 213-9. PMID 19002828 DOI: 10.1023/A:1008119512341  1
2000 Takaki Y, Iwata N, Tsubuki S, Taniguchi S, Toyoshima S, Lu B, Gerard NP, Gerard C, Lee HJ, Shirotani K, Saido TC. Biochemical identification of the neutral endopeptidase family member responsible for the catabolism of amyloid beta peptide in the brain. Journal of Biochemistry. 128: 897-902. PMID 11098130 DOI: 10.1093/Oxfordjournals.Jbchem.A022839  1
2000 Bialkowska K, Kulkarni S, Du X, Goll DE, Saido TC, Fox JE. Evidence that beta3 integrin-induced Rac activation involves the calpain-dependent formation of integrin clusters that are distinct from the focal complexes and focal adhesions that form as Rac and RhoA become active. The Journal of Cell Biology. 151: 685-96. PMID 11062268 DOI: 10.1083/jcb.151.3.685  1
2000 Harigaya Y, Saido TC, Eckman CB, Prada CM, Shoji M, Younkin SG. Amyloid beta protein starting pyroglutamate at position 3 is a major component of the amyloid deposits in the Alzheimer's disease brain. Biochemical and Biophysical Research Communications. 276: 422-7. PMID 11027491 DOI: 10.1006/Bbrc.2000.3490  1
2000 Lee HJ, Tomioka M, Takaki Y, Masumoto H, Saido TC. Molecular cloning and expression of aminopeptidase A isoforms from rat hippocampus. Biochimica Et Biophysica Acta. 1493: 273-8. PMID 10978538 DOI: 10.1016/S0167-4781(00)00183-4  1
2000 Takeuchi A, Irizarry MC, Duff K, Saido TC, Hsiao Ashe K, Hasegawa M, Mann DM, Hyman BT, Iwatsubo T. Age-related amyloid beta deposition in transgenic mice overexpressing both Alzheimer mutant presenilin 1 and amyloid beta precursor protein Swedish mutant is not associated with global neuronal loss. The American Journal of Pathology. 157: 331-9. PMID 10880403 DOI: 10.1016/S0002-9440(10)64544-0  1
2000 Russo C, Schettini G, Saido TC, Hulette C, Lippa C, Lannfelt L, Ghetti B, Gambetti P, Tabaton M, Teller JK. Presenilin-1 mutations in Alzheimer's disease. Nature. 405: 531-2. PMID 10850703 DOI: 10.1038/35014735  1
2000 Shimokata H, Yamada Y, Nakagawa M, Okubo R, Saido T, Funakoshi A, Miyasaka K, Ohta S, Tsujimoto G, Tanaka M, Ando F, Niino N. Distribution of geriatric disease-related genotypes in the National Institute for Longevity Sciences, Longitudinal Study of Aging (NILS-LSA). Journal of Epidemiology / Japan Epidemiological Association. 10: S46-55. PMID 10835828  1
2000 Kitagaki H, Tomioka S, Yoshizawa T, Sorimachi H, Saido TC, Ishiura S, Suzuki K. Autolysis of calpain large subunit inducing irreversible dissociation of stoichiometric heterodimer of calpain. Bioscience, Biotechnology, and Biochemistry. 64: 689-95. PMID 10830478 DOI: 10.1271/bbb.64.689  1
2000 Lankiewicz S, Marc Luetjens C, Truc Bui N, Krohn AJ, Poppe M, Cole GM, Saido TC, Prehn JH. Activation of calpain I converts excitotoxic neuron death into a caspase-independent cell death. The Journal of Biological Chemistry. 275: 17064-71. PMID 10828077 DOI: 10.1074/jbc.275.22.17064  1
2000 Hiwasa T, Arase Y, Kikuno K, Hasegawa R, Sugaya S, Kita K, Saido T, Yamamori H, Maki M, Suzuki N. Increase in ultraviolet sensitivity by overexpression of calpastatin in ultraviolet-resistant UVr-1 cells derived from ultraviolet-sensitive human RSa cells. Cell Death and Differentiation. 7: 531-7. PMID 10822276 DOI: 10.1038/sj.cdd.4400685  1
2000 Nakagawa Y, Reed L, Nakamura M, McIntosh TK, Smith DH, Saatman KE, Raghupathi R, Clemens J, Saido TC, Lee VM, Trojanowski JQ. Brain trauma in aged transgenic mice induces regression of established abeta deposits. Experimental Neurology. 163: 244-52. PMID 10785464 DOI: 10.1006/Exnr.2000.7375  1
2000 Saido TC. Involvement of polyglutamine endolysis followed by pyroglutamate formation in the pathogenesis of triplet repeat/polyglutamine-expansion diseases. Medical Hypotheses. 54: 427-9. PMID 10783480 DOI: 10.1054/mehy.1999.0866  1
2000 Shoji M, Kawarabayashi T, Sato M, Sasaki A, Saido TC, Matsubara E, Tomidokoro Y, Kanai M, Shizuka M, Ishiguro K, Ikeda M, Harigaya Y, Okamoto K, Hirai S. Age-related amyloid beta protein accumulation induces cellular death and macrophage activation in transgenic mice. The Journal of Pathology. 191: 93-101. PMID 10767725 DOI: 10.1002/(Sici)1096-9896(200005)191:1<93::Aid-Path567>3.0.Co;2-Q  1
2000 Yamaguchi A, Yamamoto N, Akamatsu N, Saido TC, Kaneda M, Umeda M, Tanoue K. PS-liposome and ox-LDL bind to different sites of the immunodominant domain (#155-183) of CD36: a study with GS95, a new anti-CD36 monoclonal antibody. Thrombosis Research. 97: 317-26. PMID 10709907 DOI: 10.1016/S0049-3848(99)00179-6  1
2000 Maruyama K, Usami M, Kametani F, Tomita T, Iwatsubo T, Saido TC, Mori H, Ishiura S. Molecular interactions between presenilin and calpain: inhibition of m-calpain protease activity by presenilin-1, 2 and cleavage of presenilin-1 by m-, mu-calpain. International Journal of Molecular Medicine. 5: 269-73. PMID 10677567 DOI: 10.3892/Ijmm.5.3.269  1
2000 Iwata N, Tsubuki S, Takaki Y, Watanabe K, Sekiguchi M, Hosoki E, Kawashima-Morishima M, Lee HJ, Hama E, Sekine-Aizawa Y, Saido TC. Identification of the major Abeta1-42-degrading catabolic pathway in brain parenchyma: suppression leads to biochemical and pathological deposition. Nature Medicine. 6: 143-50. PMID 10655101 DOI: 10.1038/72237  1
2000 Koike H, Kouchi Z, Kinouchi T, Maeda T, Sorimachi H, Saido TC, Maruyama K, Okuyama A, Suzuki K, Ishiura S. Metabolism of amyloid precursor protein in COS cells transfected with a β-secretase candidate Cytotechnology. 33: 213-219.  1
2000 Saido TC. Degradation of amyloid-beta peptide: A key to Alzheimer pathogenesis, prevention and therapy Neuroscience News. 3: 52-62.  1
1999 Koriyama H, Kouchi Z, Umeda T, Saido TC, Momoi T, Ishiura S, Suzuki K. Proteolytic activation of protein kinase C delta and epsilon by caspase-3 in U937 cells during chemotherapeutic agent-induced apoptosis. Cellular Signalling. 11: 831-8. PMID 10617286 DOI: 10.1016/S0898-6568(99)00055-8  1
1999 Schmidt ML, Saido TC, Lee VM, Trojanowski JQ. Spatial relationship of AMY protein deposits and different species of Abeta peptides in amyloid plaques of the Alzheimer disease brain. Journal of Neuropathology and Experimental Neurology. 58: 1227-33. PMID 10604747 DOI: 10.1097/00005072-199912000-00003  1
1999 Tomita T, Takikawa R, Koyama A, Morohashi Y, Takasugi N, Saido TC, Maruyama K, Iwatsubo T. C terminus of presenilin is required for overproduction of amyloidogenic Abeta42 through stabilization and endoproteolysis of presenilin. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 19: 10627-34. PMID 10594046  1
1999 Fukumoto H, Tomita T, Matsunaga H, Ishibashi Y, Saido TC, Iwatsubo T. Primary cultures of neuronal and non-neuronal rat brain cells secrete similar proportions of amyloid beta peptides ending at A beta40 and A beta42. Neuroreport. 10: 2965-9. PMID 10549806 DOI: 10.1097/00001756-199909290-00017  1
1999 Hayashi M, Suzuki H, Kawashima S, Saido TC, Inomata M. The behavior of calpain-generated N- and C-terminal fragments of talin in integrin-mediated signaling pathways. Archives of Biochemistry and Biophysics. 371: 133-41. PMID 10545199 DOI: 10.1006/abbi.1999.1427  1
1999 Koike H, Tomioka S, Sorimachi H, Saido TC, Maruyama K, Okuyama A, Fujisawa-Sehara A, Ohno S, Suzuki K, Ishiura S. Membrane-anchored metalloprotease MDC9 has an alpha-secretase activity responsible for processing the amyloid precursor protein. The Biochemical Journal. 343: 371-5. PMID 10510302 DOI: 10.1042/0264-6021:3430371  1
1999 Shields DC, Schaecher KE, Saido TC, Banik NL. A putative mechanism of demyelination in multiple sclerosis by a proteolytic enzyme, calpain. Proceedings of the National Academy of Sciences of the United States of America. 96: 11486-91. PMID 10500203 DOI: 10.1073/Pnas.96.20.11486  1
1999 McGowan E, Sanders S, Iwatsubo T, Takeuchi A, Saido T, Zehr C, Yu X, Uljon S, Wang R, Mann D, Dickson D, Duff K. Amyloid phenotype characterization of transgenic mice overexpressing both mutant amyloid precursor protein and mutant presenilin 1 transgenes. Neurobiology of Disease. 6: 231-44. PMID 10448051 DOI: 10.1006/Nbdi.1999.0243  1
1999 Kubo H, Matsushita M, Kotani M, Kawasaki H, Saido TC, Kawashima S, Katagiri C, Suzuki A. Molecular basis for oviductin-mediated processing from gp43 to gp41, the predominant glycoproteins of Xenopus egg envelopes. Developmental Genetics. 25: 123-9. PMID 10440846 DOI: 10.1002/(SICI)1520-6408(1999)25:2<123::AID-DVG6>3.0.CO;2-3  1
1999 Nakagawa Y, Nakamura M, McIntosh TK, Rodriguez A, Berlin JA, Smith DH, Saatman KE, Raghupathi R, Clemens J, Saido TC, Schmidt ML, Lee VM, Trojanowski JQ. Traumatic brain injury in young, amyloid-beta peptide overexpressing transgenic mice induces marked ipsilateral hippocampal atrophy and diminished Abeta deposition during aging. The Journal of Comparative Neurology. 411: 390-8. PMID 10413774 DOI: 10.1002/(Sici)1096-9861(19990830)411:3<390::Aid-Cne3>3.0.Co;2-#  1
1999 Kulkarni S, Saido TC, Suzuki K, Fox JE. Calpain mediates integrin-induced signaling at a point upstream of Rho family members. The Journal of Biological Chemistry. 274: 21265-75. PMID 10409684 DOI: 10.1074/jbc.274.30.21265  1
1999 Koike H, Seki H, Kouchi Z, Ito M, Kinouchi T, Tomioka S, Sorimachi H, Saido TC, Maruyama K, Suzuki K, Ishiura S. Thimet oligopeptidase cleaves the full-length Alzheimer amyloid precursor protein at a beta-secretase cleavage site in COS cells. Journal of Biochemistry. 126: 235-42. PMID 10393344  1
1999 Eto A, Saido TC, Fukushima K, Tomioka S, Imai S, Nisizawa T, Hanada N. Inhibitory effect of a self-derived peptide on glucosyltransferase of Streptococcus mutans. Possible novel anticaries measures. The Journal of Biological Chemistry. 274: 15797-802. PMID 10336482 DOI: 10.1074/jbc.274.22.15797  1
1999 Blomgren K, Hallin U, Andersson AL, Puka-Sundvall M, Bahr BA, McRae A, Saido TC, Kawashima S, Hagberg H. Calpastatin is up-regulated in response to hypoxia and is a suicide substrate to calpain after neonatal cerebral hypoxia-ischemia. The Journal of Biological Chemistry. 274: 14046-52. PMID 10318818 DOI: 10.1074/jbc.274.20.14046  1
1999 Yokota M, Tani E, Tsubuki S, Yamaura I, Nakagaki I, Hori S, Saido TC. Calpain inhibitor entrapped in liposome rescues ischemic neuronal damage. Brain Research. 819: 8-14. PMID 10082855 DOI: 10.1016/S0006-8993(98)01334-1  1
1999 Kitagawa K, Matsumoto M, Saido TC, Ohtsuki T, Kuwabara K, Yagita Y, Mabuchi T, Yanagihara T, Hori M. Species differences in fodrin proteolysis in the ischemic brain. Journal of Neuroscience Research. 55: 643-9. PMID 10082086 DOI: 10.1002/(SICI)1097-4547(19990301)55:5<643::AID-JNR11>3.0.CO;2-V  1
1999 Akiyama H, Mori H, Saido T, Kondo H, Ikeda K, McGeer PL. Occurrence of the diffuse amyloid beta-protein (Abeta) deposits with numerous Abeta-containing glial cells in the cerebral cortex of patients with Alzheimer's disease. Glia. 25: 324-31. PMID 10028915 DOI: 10.1002/(Sici)1098-1136(19990215)25:4<324::Aid-Glia2>3.0.Co;2-5  1
1999 Honda T, Yasutake K, Nihonmatsu N, Mercken M, Takahashi H, Murayama O, Murayama M, Sato K, Omori A, Tsubuki S, Saido TC, Takashima A. Dual roles of proteasome in the metabolism of presenilin 1. Journal of Neurochemistry. 72: 255-61. PMID 9886077  1
1999 Ray SK, Shields DC, Saido TC, Matzelle DC, Wilford GG, Hogan EL, Banik NL. Calpain activity and translational expression increased in spinal cord injury. Brain Research. 816: 375-80. PMID 9878837 DOI: 10.1016/S0006-8993(98)01128-7  1
1998 Hiwasa T, Nakamura Y, Ozaki T, Kondo K, Saido T, Nakagawara A, Sakiyama S. Down-regulation of protein kinase C alpha and gamma and enhanced TPA-induced neurite formation in DAN-transfected neuroblastoma cells. Febs Letters. 440: 25-8. PMID 9862417 DOI: 10.1016/S0014-5793(98)01412-4  1
1998 Shinozaki K, Maruyama K, Kume H, Tomita T, Saido TC, Iwatsubo T, Obata K. The presenilin 2 loop domain interacts with the mu-calpain C-terminal region. International Journal of Molecular Medicine. 1: 797-9. PMID 9852298 DOI: 10.3892/Ijmm.1.5.797  1
1998 Hosoda R, Saido TC, Otvos L, Arai T, Mann DM, Lee VM, Trojanowski JQ, Iwatsubo T. Quantification of modified amyloid beta peptides in Alzheimer disease and Down syndrome brains. Journal of Neuropathology and Experimental Neurology. 57: 1089-95. PMID 9825946 DOI: 10.1097/00005072-199811000-00012  1
1998 Ishidoh K, Saido TC, Kawashima S, Hirose M, Watanabe S, Sato N, Kominami E. Multiple processing of procathepsin L to cathepsin L in vivo. Biochemical and Biophysical Research Communications. 252: 202-7. PMID 9813170 DOI: 10.1006/bbrc.1998.9613  1
1998 Frautschy SA, Horn DL, Sigel JJ, Harris-White ME, Mendoza JJ, Yang F, Saido TC, Cole GM. Protease inhibitor coinfusion with amyloid beta-protein results in enhanced deposition and toxicity in rat brain. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 18: 8311-21. PMID 9763475  1
1998 Sudoh S, Kawamura Y, Sato S, Wang R, Saido TC, Oyama F, Sakaki Y, Komano H, Yanagisawa K. Presenilin 1 mutations linked to familial Alzheimer's disease increase the intracellular levels of amyloid beta-protein 1-42 and its N-terminally truncated variant(s) which are generated at distinct sites. Journal of Neurochemistry. 71: 1535-43. PMID 9751187  0.01
1998 Kimura Y, Koga H, Araki N, Mugita N, Fujita N, Takeshima H, Nishi T, Yamashima T, Saido TC, Yamasaki T, Moritake K, Saya H, Nakao M. The involvement of calpain-dependent proteolysis of the tumor suppressor NF2 (merlin) in schwannomas and meningiomas. Nature Medicine. 4: 915-22. PMID 9701243  1
1998 Meredith J, Mu Z, Saido T, Du X. Cleavage of the cytoplasmic domain of the integrin beta3 subunit during endothelial cell apoptosis. The Journal of Biological Chemistry. 273: 19525-31. PMID 9677375  1
1998 Oyama F, Sawamura N, Kobayashi K, Morishima-Kawashima M, Kuramochi T, Ito M, Tomita T, Maruyama K, Saido TC, Iwatsubo T, Capell A, Walter J, Grünberg J, Ueyama Y, Haass C, et al. Mutant presenilin 2 transgenic mouse: effect on an age-dependent increase of amyloid beta-protein 42 in the brain. Journal of Neurochemistry. 71: 313-22. PMID 9648880 DOI: 10.1046/J.1471-4159.1998.71010313.X  1
1998 Zalewska T, ZabÅ‚ocka B, Saido TC, Zajac H, DomaÅ„ska-Janik K. Dual response of calpain to rat brain postdecapitative ischemia. Molecular and Chemical Neuropathology / Sponsored by the International Society For Neurochemistry and the World Federation of Neurology and Research Groups On Neurochemistry and Cerebrospinal Fluid. 33: 185-97. PMID 9642672  0.01
1998 Ono Y, Shimada H, Sorimachi H, Richard I, Saido TC, Beckmann JS, Ishiura S, Suzuki K. Functional defects of a muscle-specific calpain, p94, caused by mutations associated with limb-girdle muscular dystrophy type 2A. The Journal of Biological Chemistry. 273: 17073-8. PMID 9642272 DOI: 10.1074/Jbc.273.27.17073  1
1998 Tekirian TL, Saido TC, Markesbery WR, Russell MJ, Wekstein DR, Patel E, Geddes JW. N-terminal heterogeneity of parenchymal and cerebrovascular Abeta deposits. Journal of Neuropathology and Experimental Neurology. 57: 76-94. PMID 9600199 DOI: 10.1097/00005072-199801000-00009  0.01
1998 Saido TC. Alzheimer's disease as proteolytic disorders: anabolism and catabolism of beta-amyloid. Neurobiology of Aging. 19: S69-75. PMID 9562472 DOI: 10.1016/S0197-4580(98)00033-5  0.01
1998 Funato H, Yoshimura M, Yamazaki T, Saido TC, Ito Y, Yokofujita J, Okeda R, Ihara Y. Astrocytes containing amyloid beta-protein (Abeta)-positive granules are associated with Abeta40-positive diffuse plaques in the aged human brain. The American Journal of Pathology. 152: 983-92. PMID 9546359  1
1998 Yamaguchi H, Sugihara S, Ogawa A, Saido TC, Ihara Y. Diffuse plaques associated with astroglial amyloid beta protein, possibly showing a disappearing stage of senile plaques. Acta Neuropathologica. 95: 217-22. PMID 9542585 DOI: 10.1007/s004010050790  1
1998 Tokuhiro S, Tomita T, Iwata H, Kosaka T, Saido TC, Maruyama K, Iwatsubo T. The presenilin 1 mutation (M146V) linked to familial Alzheimer's disease attenuates the neuronal differentiation of NTera 2 cells. Biochemical and Biophysical Research Communications. 244: 751-5. PMID 9535737 DOI: 10.1006/bbrc.1998.8336  1
1998 Schmidt ML, Lee VM, Saido T, Perl D, Schuck T, Iwatsubo T, Trojanowski JQ. Amyloid plaques in Guam amyotrophic lateral sclerosis/parkinsonism-dementia complex contain species of A beta similar to those found in the amyloid plaques of Alzheimer's disease and pathological aging. Acta Neuropathologica. 95: 117-22. PMID 9498044 DOI: 10.1007/S004010050774  1
1998 Frautschy SA, Yang F, Irrizarry M, Hyman B, Saido TC, Hsiao K, Cole GM. Microglial response to amyloid plaques in APPsw transgenic mice. The American Journal of Pathology. 152: 307-17. PMID 9422548  1
1997 Kouchi Z, Saido TC, Ohyama H, Maruta H, Suzuki K, Tanuma S. The restrictive proteolysis of alpha-fodrin to a 120 kDa fragment is not catalyzed by calpains during thymic apoptosis. Apoptosis : An International Journal On Programmed Cell Death. 2: 84-90. PMID 14646568  1
1997 Inomata M, Nomura K, Takehana M, Saido TC, Kawashima S, Shumiya S. Evidence for the involvement of calpain in cataractogenesis in Shumiya cataract rat (SCR). Biochimica Et Biophysica Acta. 1362: 11-23. PMID 9434095  1
1997 Sorimachi Y, Harada K, Saido TC, Ono T, Kawashima S, Yoshida K. Downregulation of calpastatin in rat heart after brief ischemia and reperfusion. Journal of Biochemistry. 122: 743-8. PMID 9399577  1
1997 Blomgren K, McRae A, Elmered A, Bona E, Kawashima S, Saido TC, Ono T, Hagberg H. The calpain proteolytic system in neonatal hypoxic-ischemia. Annals of the New York Academy of Sciences. 825: 104-19. PMID 9369979  1
1997 Saido TC, Yokota M. [Neurodegenerative diseases as proteolytic disorders: brain ischemia and Alzheimer's disease]. Tanpakushitsu Kakusan Koso. Protein, Nucleic Acid, Enzyme. 42: 2408-17. PMID 9366226  1
1997 Yan SD, Fu J, Soto C, Chen X, Zhu H, Al-Mohanna F, Collison K, Zhu A, Stern E, Saido T, Tohyama M, Ogawa S, Roher A, Stern D. An intracellular protein that binds amyloid-beta peptide and mediates neurotoxicity in Alzheimer's disease. Nature. 389: 689-95. PMID 9338779 DOI: 10.1038/39522  0.01
1997 Shin RW, Ogino K, Kondo A, Saido TC, Trojanowski JQ, Kitamoto T, Tateishi J. Amyloid beta-protein (Abeta) 1-40 but not Abeta1-42 contributes to the experimental formation of Alzheimer disease amyloid fibrils in rat brain. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 17: 8187-93. PMID 9334394  1
1997 Schoenwaelder SM, Kulkarni S, Salem HH, Imajoh-Ohmi S, Yamao-Harigaya W, Saido TC, Jackson SP. Distinct substrate specificities and functional roles for the 78- and 76-kDa forms of mu-calpain in human platelets. The Journal of Biological Chemistry. 272: 24876-84. PMID 9312088  1
1997 Russo C, Saido TC, DeBusk LM, Tabaton M, Gambetti P, Teller JK. Heterogeneity of water-soluble amyloid beta-peptide in Alzheimer's disease and Down's syndrome brains. Febs Letters. 409: 411-6. PMID 9224700 DOI: 10.1016/S0014-5793(97)00564-4  1
1997 Yamazaki M, Ishidoh K, Suga Y, Saido TC, Kawashima S, Suzuki K, Kominami E, Ogawa H. Cytoplasmic processing of human profilaggrin by active mu-calpain. Biochemical and Biophysical Research Communications. 235: 652-6. PMID 9207214 DOI: 10.1006/bbrc.1997.6809  1
1997 Yamazaki T, Haass C, Saido TC, Omura S, Ihara Y. Specific increase in amyloid beta-protein 42 secretion ratio by calpain inhibition. Biochemistry. 36: 8377-83. PMID 9204885 DOI: 10.1021/Bi970209Y  1
1997 Saito Y, Maruyama K, Saido TC, Kawashima S. Overexpression of a neuropeptide nociceptin/orphanin FQ precursor gene, N23K/N27K, induces neurite outgrowth in mouse NS20Y cells. Journal of Neuroscience Research. 48: 397-406. PMID 9185664 DOI: 10.1002/(SICI)1097-4547(19970601)48:5<397::AID-JNR2>3.0.CO;2-9  1
1997 Saido TC, Kawashima S, Tani E, Yokota M. Up- and down-regulation of calpain inhibitor polypeptide, calpastatin, in postischemic hippocampus. Neuroscience Letters. 227: 75-8. PMID 9180207 DOI: 10.1016/S0304-3940(97)00309-1  1
1997 Didier M, Xu M, Berman SA, Saido TC, Bursztajn S. Involvement of three glutamate receptor epsilon subunits in the formation of N-methyl-D-aspartate receptors mediating excitotoxicity in primary cultures of mouse cerebellar granule cells. Neuroscience. 78: 1129-46. PMID 9174079  0.01
1997 Mann DM, Pickering-Brown SM, Bayatti NN, Wright AE, Owen F, Iwatsubo T, Saido TC. An intronic polymorphism in the presenilin-1 gene does not influence the amount or molecular form of the amyloid beta protein deposited in Alzheimer's disease. Neuroscience Letters. 222: 57-60. PMID 9121723 DOI: 10.1016/S0304-3940(97)13342-0  1
1997 Kuda T, Shoji M, Arai H, Kawashima S, Saido TC. Reduction of plasma glutamyl aminopeptidase activity in sporadic Alzheimer's disease. Biochemical and Biophysical Research Communications. 231: 526-30. PMID 9070837 DOI: 10.1006/bbrc.1996.5920  1
1997 Tomita T, Maruyama K, Saido TC, Kume H, Shinozaki K, Tokuhiro S, Capell A, Walter J, Grünberg J, Haass C, Iwatsubo T, Obata K. The presenilin 2 mutation (N141I) linked to familial Alzheimer disease (Volga German families) increases the secretion of amyloid beta protein ending at the 42nd (or 43rd) residue. Proceedings of the National Academy of Sciences of the United States of America. 94: 2025-30. PMID 9050898 DOI: 10.1073/Pnas.94.5.2025  1
1996 Lemere CA, Blusztajn JK, Yamaguchi H, Wisniewski T, Saido TC, Selkoe DJ. Sequence of deposition of heterogeneous amyloid beta-peptides and APO E in Down syndrome: implications for initial events in amyloid plaque formation. Neurobiology of Disease. 3: 16-32. PMID 9173910 DOI: 10.1006/Nbdi.1996.0003  1
1996 Iwatsubo T, Saido TC, Mann DM, Lee VM, Trojanowski JQ. Full-length amyloid-beta (1-42(43)) and amino-terminally modified and truncated amyloid-beta 42(43) deposit in diffuse plaques. The American Journal of Pathology. 149: 1823-30. PMID 8952519  1
1996 Saido TC. [Spatial resolution of proteolytic reactions in brain ischemia and Alzheimer's disease]. Seikagaku. the Journal of Japanese Biochemical Society. 68: 1507-22. PMID 8921716  0.01
1996 Yamashima T, Saido TC, Takita M, Miyazawa A, Yamano J, Miyakawa A, Nishijyo H, Yamashita J, Kawashima S, Ono T, Yoshioka T. Transient brain ischaemia provokes Ca2+, PIP2 and calpain responses prior to delayed neuronal death in monkeys. The European Journal of Neuroscience. 8: 1932-44. PMID 8921284 DOI: 10.1111/J.1460-9568.1996.Tb01337.X  1
1996 Saido TC, Yamao-Harigaya W, Iwatsubo T, Kawashima S. Amino- and carboxyl-terminal heterogeneity of beta-amyloid peptides deposited in human brain. Neuroscience Letters. 215: 173-6. PMID 8899741 DOI: 10.1016/0304-3940(96)12970-0  1
1996 Yokota M, Saido TC, Tani E, Yamaura I, Minami N. Cytotoxic fragment of amyloid precursor protein accumulates in hippocampus after global forebrain ischemia. Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism. 16: 1219-23. PMID 8898694 DOI: 10.1097/00004647-199611000-00016  1
1996 Maruyama K, Tomita T, Shinozaki K, Kume H, Asada H, Saido TC, Ishiura S, Iwatsubo T, Obata K. Familial Alzheimer's disease-linked mutations at Val717 of amyloid precursor protein are specific for the increased secretion of A beta 42(43). Biochemical and Biophysical Research Communications. 227: 730-5. PMID 8886002 DOI: 10.1006/bbrc.1996.1577  1
1996 Lemere CA, Lopera F, Kosik KS, Lendon CL, Ossa J, Saido TC, Yamaguchi H, Ruiz A, Martinez A, Madrigal L, Hincapie L, Arango JC, Anthony DC, Koo EH, Goate AM, et al. The E280A presenilin 1 Alzheimer mutation produces increased A beta 42 deposition and severe cerebellar pathology. Nature Medicine. 2: 1146-50. PMID 8837617 DOI: 10.1038/Nm1096-1146  1
1996 Saito Y, Maruyama K, Kawano H, Hagino-Yamagishi K, Kawamura K, Saido TC, Kawashima S. Molecular cloning and characterization of a novel form of neuropeptide gene as a developmentally regulated molecule. The Journal of Biological Chemistry. 271: 15615-22. PMID 8663129  1
1996 Inomata M, Hayashi M, Ohno-Iwashita Y, Tsubuki S, Saido TC, Kawashima S. Involvement of calpain in integrin-mediated signal transduction. Archives of Biochemistry and Biophysics. 328: 129-34. PMID 8638921 DOI: 10.1006/abbi.1996.0152  1
1996 Kanai Y, Kanai-Azuma M, Noce T, Saido TC, Shiroishi T, Hayashi Y, Yazaki K. Identification of two Sox17 messenger RNA isoforms, with and without the high mobility group box region, and their differential expression in mouse spermatogenesis. The Journal of Cell Biology. 133: 667-81. PMID 8636240  0.01
1996 Kume H, Maruyama K, Tomita T, Iwatsubo T, Saido TC, Obata K. Molecular cloning of a novel basic helix-loop-helix protein from the rat brain. Biochemical and Biophysical Research Communications. 219: 526-30. PMID 8605021 DOI: 10.1006/bbrc.1996.0267  1
1995 Bednarski E, Vanderklish P, Gall C, Saido TC, Bahr BA, Lynch G. Translational suppression of calpain I reduces NMDA-induced spectrin proteolysis and pathophysiology in cultured hippocampal slices. Brain Research. 694: 147-57. PMID 8974639 DOI: 10.1016/0006-8993(95)00851-G  1
1995 Mizuno K, Noda K, Ueda Y, Hanaki H, Saido TC, Ikuta T, Kuroki T, Tamaoki T, Hirai S, Osada S. UCN-01, an anti-tumor drug, is a selective inhibitor of the conventional PKC subfamily. Febs Letters. 359: 259-61. PMID 7867810  1
1995 Saido TC, Iwatsubo T, Mann DM, Shimada H, Ihara Y, Kawashima S. Dominant and differential deposition of distinct beta-amyloid peptide species, A beta N3(pE), in senile plaques. Neuron. 14: 457-66. PMID 7857653 DOI: 10.1016/0896-6273(95)90301-1  1
1995 Hong DH, Huan J, Ou BR, Yeh JY, Saido TC, Cheeke PR, Forsberg NE. Protein kinase C isoforms in muscle cells and their regulation by phorbol ester and calpain. Biochimica Et Biophysica Acta. 1267: 45-54. PMID 7779868 DOI: 10.1016/0167-4889(95)00024-M  0.01
1995 Yoshida K, Inui M, Harada K, Saido TC, Sorimachi Y, Ishihara T, Kawashima S, Sobue K. Reperfusion of rat heart after brief ischemia induces proteolysis of calspectin (nonerythroid spectrin or fodrin) by calpain. Circulation Research. 77: 603-10. PMID 7641330  1
1995 Harigaya Y, Shoji M, Kawarabayashi T, Kanai M, Nakamura T, Iizuka T, Igeta Y, Saido TC, Sahara N, Mori H. Modified amyloid beta protein ending at 42 or 40 with different solubility accumulates in the brain of Alzheimer's disease. Biochemical and Biophysical Research Communications. 211: 1015-22. PMID 7598687  1
1995 Du X, Saido TC, Tsubuki S, Indig FE, Williams MJ, Ginsberg MH. Calpain cleavage of the cytoplasmic domain of the integrin beta 3 subunit. The Journal of Biological Chemistry. 270: 26146-51. PMID 7592818 DOI: 10.1074/Jbc.270.44.26146  1
1995 Blomgren K, Kawashima S, Saido TC, Karlsson JO, Elmered A, Hagberg H. Fodrin degradation and subcellular distribution of calpains after neonatal rat cerebral hypoxic-ischemia. Brain Research. 684: 143-9. PMID 7583215  1
1995 Blomgren K, McRae A, Bona E, Saido TC, Karlsson JO, Hagberg H. Degradation of fodrin and MAP 2 after neonatal cerebral hypoxic-ischemia. Brain Research. 684: 136-42. PMID 7583214  1
1995 Yokota M, Saido TC, Tani E, Kawashima S, Suzuki K. Three distinct phases of fodrin proteolysis induced in postischemic hippocampus. Involvement of calpain and unidentified protease. Stroke; a Journal of Cerebral Circulation. 26: 1901-7. PMID 7570746 DOI: 10.1161/01.Str.26.10.1901  1
1995 Eto A, Akita Y, Saido TC, Suzuki K, Kawashima S. The role of the calpain-calpastatin system in thyrotropin-releasing hormone-induced selective down-regulation of a protein kinase C isozyme, nPKC epsilon, in rat pituitary GH4C1 cells. The Journal of Biological Chemistry. 270: 25115-20. PMID 7559644  1
1995 Martin SJ, O'Brien GA, Nishioka WK, McGahon AJ, Mahboubi A, Saido TC, Green DR. Proteolysis of fodrin (non-erythroid spectrin) during apoptosis. The Journal of Biological Chemistry. 270: 6425-8. PMID 7534762 DOI: 10.1074/Jbc.270.12.6425  0.01
1995 Saito Y, Maruyama K, Saido TC, Kawashima S. N23K, a gene transiently up-regulated during neural differentiation, encodes a precursor protein for a newly identified neuropeptide nociceptin. Biochemical and Biophysical Research Communications. 217: 539-45. PMID 7503733 DOI: 10.1006/bbrc.1995.2809  1
1995 Vanderklish P, Saido TC, Gall C, Arai A, Lynch G. Proteolysis of spectrin by calpain accompanies theta-burst stimulation in cultured hippocampal slices. Brain Research. Molecular Brain Research. 32: 25-35. PMID 7494460 DOI: 10.1016/0169-328X(95)00057-Y  1
1995 Igarashi K, Kaneda M, Yamaji A, Saido TC, Kikkawa U, Ono Y, Inoue K, Umeda M. A novel phosphatidylserine-binding peptide motif defined by an anti-idiotypic monoclonal antibody. Localization of phosphatidylserine-specific binding sites on protein kinase C and phosphatidylserine decarboxylase. The Journal of Biological Chemistry. 270: 29075-8. PMID 7493929 DOI: 10.1074/JBC.270.49.29075  1
1994 Akita Y, Ohno S, Yajima Y, Konno Y, Saido TC, Mizuno K, Chida K, Osada S, Kuroki T, Kawashima S. Overproduction of a Ca(2+)-independent protein kinase C isozyme, nPKC epsilon, increases the secretion of prolactin from thyrotropin-releasing hormone-stimulated rat pituitary GH4C1 cells. The Journal of Biological Chemistry. 269: 4653-60. PMID 8308036  1
1994 Saido TC, Yokota M, Maruyama K, Yamao-Harigaya W, Tani E, Ihara Y, Kawashima S. Spatial resolution of the primary beta-amyloidogenic process induced in postischemic hippocampus. The Journal of Biological Chemistry. 269: 15253-7. PMID 8195161  1
1994 Sorimachi H, Saido TC, Suzuki K. New era of calpain research. Discovery of tissue-specific calpains. Febs Letters. 343: 1-5. PMID 8163008 DOI: 10.1016/0014-5793(94)80595-4  1
1994 Saido TC, Sorimachi H, Suzuki K. Calpain: new perspectives in molecular diversity and physiological-pathological involvement. Faseb Journal : Official Publication of the Federation of American Societies For Experimental Biology. 8: 814-22. PMID 8070630  1
1994 Saido TC, Nagao S, Shiramine M, Tsukaguchi M, Yoshizawa T, Sorimachi H, Ito H, Tsuchiya T, Kawashima S, Suzuki K. Distinct kinetics of subunit autolysis in mammalian m-calpain activation. Febs Letters. 346: 263-7. PMID 8013644  1
1994 Satake A, Itoh K, Shimmoto M, Saido TC, Sakuraba H, Suzuki Y. Distribution of lysosomal protective protein in human tissues. Biochemical and Biophysical Research Communications. 205: 38-43. PMID 7999052 DOI: 10.1006/bbrc.1994.2626  0.01
1994 Nagao S, Saido TC, Akita Y, Tsuchiya T, Suzuki K, Kawashima S. Calpain-calpastatin interactions in epidermoid carcinoma KB cells. Journal of Biochemistry. 115: 1178-84. PMID 7982901  1
1994 Saito Y, Saido TC, Sano K, Kawashima S. The calpain-calpastatin system is regulated differently during human neuroblastoma cell differentiation to Schwannian and neuronal cells. Febs Letters. 353: 327-31. PMID 7957886  1
1994 Yokota M, Saido TC, Miyaji K, Tani E, Kawashima S, Suzuki K. Stimulation of protein-tyrosine phosphorylation in gerbil hippocampus after global forebrain ischemia. Neuroscience Letters. 168: 69-72. PMID 7518068 DOI: 10.1016/0304-3940(94)90418-9  1
1993 Sorimachi H, Toyama-Sorimachi N, Saido TC, Kawasaki H, Sugita H, Miyasaka M, Arahata K, Ishiura S, Suzuki K. Muscle-specific calpain, p94, is degraded by autolysis immediately after translation, resulting in disappearance from muscle. The Journal of Biological Chemistry. 268: 10593-605. PMID 8486713  1
1993 Saido TC, Suzuki H, Yamazaki H, Tanoue K, Suzuki K. In situ capture of mu-calpain activation in platelets. The Journal of Biological Chemistry. 268: 7422-6. PMID 8463275  1
1993 Yamaura I, Tani E, Saido TC, Suzuki K, Minami N, Maeda Y. Calpain-calpastatin system of canine basilar artery in vasospasm. Journal of Neurosurgery. 79: 537-43. PMID 8410223 DOI: 10.3171/Jns.1993.79.4.0537  1
1993 Mizuno K, Saido TC, Ohno S, Tamaoki T, Suzuki K. Staurosporine-related compounds, K252a and UCN-01, inhibit both cPKC and nPKC. Febs Letters. 330: 114-6. PMID 8365480  1
1993 Saido TC, Yokota M, Nagao S, Yamaura I, Tani E, Tsuchiya T, Suzuki K, Kawashima S. Spatial resolution of fodrin proteolysis in postischemic brain. The Journal of Biological Chemistry. 268: 25239-43. PMID 8227089  1
1992 Saido TC, Mizuno K, Konno Y, Osada S, Ohno S, Suzuki K. Purification and characterization of protein kinase C epsilon from rabbit brain. Biochemistry. 31: 482-90. PMID 1731907  1
1992 Saido TC, Nagao S, Shiramine M, Tsukaguchi M, Sorimachi H, Murofushi H, Tsuchiya T, Ito H, Suzuki K. Autolytic transition of mu-calpain upon activation as resolved by antibodies distinguishing between the pre- and post-autolysis forms. Journal of Biochemistry. 111: 81-6. PMID 1607367  1
1992 Kawashima S, Saido TC. [Physiological function of calpains]. Tanpakushitsu Kakusan Koso. Protein, Nucleic Acid, Enzyme. 37: 2144-60. PMID 1529105  1
1992 Osada S, Mizuno K, Saido TC, Suzuki K, Kuroki T, Ohno S. A new member of the protein kinase C family, nPKC theta, predominantly expressed in skeletal muscle. Molecular and Cellular Biology. 12: 3930-8. PMID 1508194  1
1992 Suzuki K, Saido TC, Hirai S. Modulation of cellular signals by calpain. Annals of the New York Academy of Sciences. 674: 218-27. PMID 1337690  1
1992 Saido TC, Shibata M, Takenawa T, Murofushi H, Suzuki K. Positive regulation of mu-calpain action by polyphosphoinositides. The Journal of Biological Chemistry. 267: 24585-90. PMID 1332961  1
1991 Mori A, Aizawa H, Saido TC, Kawasaki H, Mizuno K, Murofushi H, Suzuki K, Sakai H. Site-specific phosphorylation by protein kinase C inhibits assembly-promoting activity of microtubule-associated protein 4. Biochemistry. 30: 9341-6. PMID 1892837  1
1991 Ohno S, Akita Y, Hata A, Osada S, Kubo K, Konno Y, Akimoto K, Mizuno K, Saido T, Kuroki T. Structural and functional diversities of a family of signal transducing protein kinases, protein kinase C family; two distinct classes of PKC, conventional cPKC and novel nPKC. Advances in Enzyme Regulation. 31: 287-303. PMID 1877391 DOI: 10.1016/0065-2571(91)90018-H  1
1991 Mizuno K, Kubo K, Saido TC, Akita Y, Osada S, Kuroki T, Ohno S, Suzuki K. Structure and properties of a ubiquitously expressed protein kinase C, nPKC delta. European Journal of Biochemistry / Febs. 202: 931-40. PMID 1765103 DOI: 10.1111/J.1432-1033.1991.TB16453.X  1
1991 Saido TC, Mizuno K, Suzuki K. Proteolysis of protein kinase C by calpain: effect of acidic phospholipids. Biomedica Biochimica Acta. 50: 485-9. PMID 1666283  1
1990 Sorimachi H, Ohmi S, Emori Y, Kawasaki H, Saido TC, Ohno S, Minami Y, Suzuki K. A novel member of the calcium-dependent cysteine protease family. Biological Chemistry Hoppe-Seyler. 371: 171-6. PMID 2400579  1
1990 Osada S, Mizuno K, Saido TC, Akita Y, Suzuki K, Kuroki T, Ohno S. A phorbol ester receptor/protein kinase, nPKC eta, a new member of the protein kinase C family predominantly expressed in lung and skin. The Journal of Biological Chemistry. 265: 22434-40. PMID 2266135  1
1990 Saido TC, Suzuki K. [Calcium-activated neutral proteases in cell injury]. Tanpakushitsu Kakusan Koso. Protein, Nucleic Acid, Enzyme. 35: 1864-70. PMID 2236600  1
1990 Kobayashi Y, Yamamoto K, Saido T, Kawasaki H, Oppenheim JJ, Matsushima K. Identification of calcium-activated neutral protease as a processing enzyme of human interleukin 1 alpha. Proceedings of the National Academy of Sciences of the United States of America. 87: 5548-52. PMID 2115174  1
1987 Saido TC, Toyoshima S, Osawa T. Protein-O-carboxylmethyltransferase from cytosol and membranes of chicken erythrocytes. Journal of Biochemistry. 102: 319-26. PMID 3667573  1
1983 Toyoshima S, Saido T, Makishima F, Osawa T. Induction of increased calcium uptake in liposomes having membrane proteins of chicken erythrocytes by S-adenosylmethionine. Biochemical and Biophysical Research Communications. 114: 1126-31. PMID 6615507  1
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