Thomas Höfer - Publications

Affiliations: 
German Cancer Research Center, Heidelberg, Baden-Württemberg, Germany 

66 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2020 Pei W, Shang F, Wang X, Fanti AK, Greco A, Busch K, Klapproth K, Zhang Q, Quedenau C, Sauer S, Feyerabend TB, Höfer T, Rodewald HR. Resolving Fates and Single-Cell Transcriptomes of Hematopoietic Stem Cell Clones by PolyloxExpress Barcoding. Cell Stem Cell. PMID 32783885 DOI: 10.1016/J.Stem.2020.07.018  0.356
2020 Ni J, Wang X, Stojanovic A, Zhang Q, Wincher M, Bühler L, Arnold A, Correia MP, Winkler M, Koch PS, Sexl V, Höfer T, Cerwenka A. Single-Cell RNA Sequencing of Tumor-Infiltrating NK Cells Reveals that Inhibition of Transcription Factor HIF-1α Unleashes NK Cell Activity. Immunity. PMID 32445619 DOI: 10.1016/J.Immuni.2020.05.001  0.334
2020 Bheda P, Aguilar-Gómez D, Becker NB, Becker J, Stavrou E, Kukhtevich I, Höfer T, Maerkl S, Charvin G, Marr C, Kirmizis A, Schneider R. Single-Cell Tracing Dissects Regulation of Maintenance and Inheritance of Transcriptional Reinduction Memory. Molecular Cell. PMID 32392469 DOI: 10.1016/J.Molcel.2020.04.016  0.301
2020 Kuchen EE, Becker NB, Claudino N, Höfer T. Hidden long-range memories of growth and cycle speed correlate cell cycles in lineage trees. Elife. 9. PMID 31971512 DOI: 10.7554/Elife.51002  0.399
2019 Freund C, Höfer T. A Missing Switch in Peptide Exchange for MHC Class II Molecules. Frontiers in Immunology. 10: 2513. PMID 31708929 DOI: 10.3389/Fimmu.2019.02513  0.302
2019 Mende N, Jolly A, Percin GI, Günther M, Rostovskaya M, Krishnan SM, Oostendorp RAJ, Dahl A, Anastassiadis K, Höfer T, Waskow C. Prospective isolation of non-hematopoietic cells of the niche and their differential molecular interactions with HSCs. Blood. PMID 31366622 DOI: 10.1182/Blood.2019000176  0.377
2019 Pei W, Wang X, Rössler J, Feyerabend TB, Höfer T, Rodewald HR. Using Cre-recombinase-driven Polylox barcoding for in vivo fate mapping in mice. Nature Protocols. PMID 31110297 DOI: 10.1038/S41596-019-0163-5  0.349
2019 Yousefi OS, Günther M, Hörner M, Chalupsky J, Wess M, Brandl SM, Smith RW, Fleck C, Kunkel T, Zurbriggen MD, Höfer T, Weber W, Schamel WW. Optogenetic control shows that kinetic proofreading regulates the activity of the T cell receptor. Elife. 8. PMID 30947807 DOI: 10.7554/Elife.42475  0.305
2019 Yousefi OS, Günther M, Hörner M, Chalupsky J, Wess M, Brandl SM, Smith RW, Fleck C, Kunkel T, Zurbriggen MD, Höfer T, Weber W, Schamel WW. Author response: Optogenetic control shows that kinetic proofreading regulates the activity of the T cell receptor Elife. DOI: 10.7554/Elife.42475.064  0.329
2019 Mertens D, Wolf C, Maus C, Persicke M, Filarsky K, Döhner H, Lichter P, Höfer T, Stilgenbauer S. Modelling Single Cell B-Cell Receptor Signaling Reveals Enhanced Activity in Primary CLL Cells Compared to Non-Malignant Cells While Fundamental Network Circuit Topology Remains Stable Even with Novel Therapeutic Inhibitors Blood. 134: 4275-4275. DOI: 10.1182/Blood-2019-127837  0.394
2018 Becker NB, Günther M, Li C, Jolly A, Höfer T. Stem cell homeostasis by integral feedback through the niche. Journal of Theoretical Biology. PMID 30579956 DOI: 10.1016/J.Jtbi.2018.12.029  0.382
2018 Pervolaraki K, Rastgou Talemi S, Albrecht D, Bormann F, Bamford C, Mendoza JL, Garcia KC, McLauchlan J, Höfer T, Stanifer ML, Boulant S. Differential induction of interferon stimulated genes between type I and type III interferons is independent of interferon receptor abundance. Plos Pathogens. 14: e1007420. PMID 30485383 DOI: 10.1371/Journal.Ppat.1007420  0.322
2018 Talemi SR, Höfer T. Antiviral interferon response at single-cell resolution. Immunological Reviews. 285: 72-80. PMID 30129203 DOI: 10.1111/Imr.12699  0.33
2018 Höfer T, Rodewald HR. Differentiation-based model of hematopoietic stem cell functions and lineage pathways. Blood. 132: 1106-1113. PMID 30042097 DOI: 10.1182/Blood-2018-03-791517  0.369
2018 Murugan R, Buchauer L, Triller G, Kreschel C, Costa G, Pidelaserra Martí G, Imkeller K, Busse CE, Chakravarty S, Sim BKL, Hoffman SL, Levashina EA, Kremsner PG, Mordmüller B, Höfer T, et al. Clonal selection drives protective memory B cell responses in controlled human malaria infection. Science Immunology. 3. PMID 29453292 DOI: 10.1126/Sciimmunol.Aap8029  0.326
2018 Arndt K, Kranz A, Fohgrub J, Jolly A, Bledau AS, Di Virgilio M, Lesche M, Dahl A, Höfer T, Stewart AF, Waskow C. SETD1A protects HSCs from activation-induced functional decline in vivo. Blood. PMID 29348130 DOI: 10.1182/Blood-2017-09-806844  0.326
2018 Mutlu A, Trauth S, Ziesack M, Nagler K, Bergeest JP, Rohr K, Becker N, Höfer T, Bischofs IB. Phenotypic memory in Bacillus subtilis links dormancy entry and exit by a spore quantity-quality tradeoff. Nature Communications. 9: 69. PMID 29302032 DOI: 10.1038/S41467-017-02477-1  0.321
2018 Sacirbegovic F, Rosenberger ST, Zhao D, Günther M, Oberbarnscheidt MH, Lakkis FG, Höfer T, Shlomchik WD. GVHD Is Sustained By T Cell Maintenance within Target Tissues: Insights from Clonal Tracking and Parabiosis Blood. 132: 809-809. DOI: 10.1182/Blood-2018-99-119134  0.346
2018 Westermann F, Alborzinia H, Gogolin S, Flórez AF, Brückner LM, Gartlgruber M, Hartlieb S, Dreidax D, Nadler-Holly M, Ziehm M, Shao C, Selbach M, Stresemann C, Poschet G, Nicke B, et al. Abstract 4973: MYCN mediates cysteine addiction and sensitizes to ferroptosis in cancer cells Cancer Research. 78: 4973-4973. DOI: 10.1158/1538-7445.Am2018-4973  0.333
2017 Ryl T, Kuchen EE, Bell E, Shao C, Flórez AF, Mönke G, Gogolin S, Friedrich M, Lamprecht F, Westermann F, Höfer T. Cell-Cycle Position of Single MYC-Driven Cancer Cells Dictates Their Susceptibility to a Chemotherapeutic Drug. Cell Systems. PMID 28843484 DOI: 10.1016/J.Cels.2017.07.005  0.386
2017 Pei W, Feyerabend TB, Rössler J, Wang X, Postrach D, Busch K, Rode I, Klapproth K, Dietlein N, Quedenau C, Chen W, Sauer S, Wolf S, Höfer T, Rodewald HR. Polylox barcoding reveals haematopoietic stem cell fates realized in vivo. Nature. PMID 28813413 DOI: 10.1038/Nature23653  0.375
2017 Cho YL, Flossdorf M, Kretschmer L, Höfer T, Busch DH, Buchholz VR. TCR Signal Quality Modulates Fate Decisions of Single CD4(+) T Cells in a Probabilistic Manner. Cell Reports. 20: 806-818. PMID 28746867 DOI: 10.1016/J.Celrep.2017.07.005  0.365
2017 Adlung L, Kar S, Wagner MC, She B, Chakraborty S, Bao J, Lattermann S, Boerries M, Busch H, Wuchter P, Ho AD, Timmer J, Schilling M, Höfer T, Klingmüller U. Protein abundance of AKT and ERK pathway components governs cell type-specific regulation of proliferation. Molecular Systems Biology. 13: 904. PMID 28123004 DOI: 10.15252/Msb.20167258  0.701
2017 Schamel WW, Alarcon B, Höfer T, Minguet S. The Allostery Model of TCR Regulation. Journal of Immunology (Baltimore, Md. : 1950). 198: 47-52. PMID 27994168 DOI: 10.4049/Jimmunol.1601661  0.326
2016 Shao C, Höfer T. Robust classification of single-cell transcriptome data by nonnegative matrix factorization. Bioinformatics (Oxford, England). PMID 27663498 DOI: 10.1093/Bioinformatics/Btw607  0.326
2016 Höfer T, Rodewald HR. Output without input: the lifelong productivity of hematopoietic stem cells. Current Opinion in Cell Biology. 43: 69-77. PMID 27620508 DOI: 10.1016/J.Ceb.2016.08.003  0.346
2016 Swamy M, Beck-Garcia K, Beck-Garcia E, Hartl FA, Morath A, Yousefi OS, Dopfer EP, Molnár E, Schulze AK, Blanco R, Borroto A, Martín-Blanco N, Alarcon B, Höfer T, Minguet S, et al. A Cholesterol-Based Allostery Model of T Cell Receptor Phosphorylation. Immunity. 44: 1091-101. PMID 27192576 DOI: 10.1016/J.Immuni.2016.04.011  0.326
2016 Höfer T, Busch K, Klapproth K, Rodewald HR. Fate Mapping and Quantitation of Hematopoiesis In Vivo. Annual Review of Immunology. 34: 449-78. PMID 27168243 DOI: 10.1146/Annurev-Immunol-032414-112019  0.344
2016 Höfer T, Barile M, Flossdorf M. Stem-cell dynamics and lineage topology from in vivo fate mapping in the hematopoietic system. Current Opinion in Biotechnology. 39: 150-156. PMID 27107166 DOI: 10.1016/J.Copbio.2016.04.001  0.366
2015 Schmid B, Rinas M, Ruggieri A, Acosta EG, Bartenschlager M, Reuter A, Fischl W, Harder N, Bergeest JP, Flossdorf M, Rohr K, Höfer T, Bartenschlager R. Live Cell Analysis and Mathematical Modeling Identify Determinants of Attenuation of Dengue Virus 2'-O-Methylation Mutant. Plos Pathogens. 11: e1005345. PMID 26720415 DOI: 10.1371/Journal.Ppat.1005345  0.331
2015 Flossdorf M, Rössler J, Buchholz VR, Busch DH, Höfer T. CD8(+) T cell diversification by asymmetric cell division. Nature Immunology. 16: 891-3. PMID 26287584 DOI: 10.1038/Ni.3235  0.321
2015 Mende N, Kuchen EE, Lesche M, Grinenko T, Kokkaliaris KD, Hanenberg H, Lindemann D, Dahl A, Platz A, Höfer T, Calegari F, Waskow C. CCND1-CDK4-mediated cell cycle progression provides a competitive advantage for human hematopoietic stem cells in vivo. The Journal of Experimental Medicine. 212: 1171-83. PMID 26150472 DOI: 10.1084/Jem.20150308  0.379
2015 Thurley K, Gerecht D, Friedmann E, Höfer T. Three-Dimensional Gradients of Cytokine Signaling between T Cells. Plos Computational Biology. 11: e1004206. PMID 25923703 DOI: 10.1371/Journal.Pcbi.1004206  0.384
2015 Busch K, Klapproth K, Barile M, Flossdorf M, Holland-Letz T, Schlenner SM, Reth M, Höfer T, Rodewald HR. Fundamental properties of unperturbed haematopoiesis from stem cells in vivo. Nature. 518: 542-6. PMID 25686605 DOI: 10.1038/Nature14242  0.339
2014 Müller-Ott K, Erdel F, Matveeva A, Mallm JP, Rademacher A, Hahn M, Bauer C, Zhang Q, Kaltofen S, Schotta G, Höfer T, Rippe K. Specificity, propagation, and memory of pericentric heterochromatin. Molecular Systems Biology. 10: 746. PMID 25134515 DOI: 10.15252/Msb.20145377  0.312
2014 Teif VB, Beshnova DA, Vainshtein Y, Marth C, Mallm JP, Höfer T, Rippe K. Nucleosome repositioning links DNA (de)methylation and differential CTCF binding during stem cell development. Genome Research. 24: 1285-95. PMID 24812327 DOI: 10.1101/Gr.164418.113  0.333
2014 Verbruggen P, Heinemann T, Manders E, von Bornstaedt G, van Driel R, Höfer T. Robustness of DNA Repair through Collective Rate Control Plos Computational Biology. 10. PMID 24499930 DOI: 10.1371/Journal.Pcbi.1003438  0.307
2012 Meyer R, D'Alessandro LA, Kar S, Kramer B, She B, Kaschek D, Hahn B, Wrangborg D, Karlsson J, Kvarnström M, Jirstrand M, Lehmann WD, Timmer J, Höfer T, Klingmüller U. Heterogeneous kinetics of AKT signaling in individual cells are accounted for by variable protein concentration. Frontiers in Physiology. 3: 451. PMID 23226133 DOI: 10.3389/Fphys.2012.00451  0.693
2012 Teif VB, Vainshtein Y, Caudron-Herger M, Mallm JP, Marth C, Höfer T, Rippe K. Genome-wide nucleosome positioning during embryonic stem cell development. Nature Structural & Molecular Biology. 19: 1185-92. PMID 23085715 DOI: 10.1038/Nsmb.2419  0.323
2012 Höfer T, Krichevsky O, Altan-Bonnet G. Competition for IL-2 between Regulatory and Effector T Cells to Chisel Immune Responses. Frontiers in Immunology. 3: 268. PMID 22973270 DOI: 10.3389/Fimmu.2012.00268  0.303
2012 Rand U, Rinas M, Schwerk J, Nöhren G, Linnes M, Kröger A, Flossdorf M, Kály‐Kullai K, Hauser H, Höfer T, Köster M. Multi-layered stochasticity and paracrine signal propagation shape the type-I interferon response. Molecular Systems Biology. 8: 584-584. PMID 22617958 DOI: 10.1038/Msb.2012.17  0.359
2011 Deswal S, Schulze AK, Höfer T, Schamel WW. Quantitative analysis of protein phosphorylations and interactions by multi-colour IP-FCM as an input for kinetic modelling of signalling networks. Plos One. 6: e22928. PMID 21829558 DOI: 10.1371/Journal.Pone.0022928  0.327
2010 Salazar C, Brümmer A, Alberghina L, Höfer T. Timing control in regulatory networks by multisite protein modifications. Trends in Cell Biology. 20: 634-41. PMID 20869247 DOI: 10.1016/J.Tcb.2010.08.012  0.359
2010 Brümmer A, Salazar C, Zinzalla V, Alberghina L, Höfer T. Mathematical modelling of DNA replication reveals a trade-off between coherence of origin activation and robustness against rereplication. Plos Computational Biology. 6: e1000783. PMID 20485558 DOI: 10.1371/Journal.Pcbi.1000783  0.301
2010 Mariani L, Schulz EG, Lexberg MH, Helmstetter C, Radbruch A, Löhning M, Höfer T. Short-term memory in gene induction reveals the regulatory principle behind stochastic IL-4 expression. Molecular Systems Biology. 6: 359. PMID 20393579 DOI: 10.1038/Msb.2010.13  0.371
2009 Alberghina L, Höfer T, Vanoni M. Molecular networks and system-level properties. Journal of Biotechnology. 144: 224-33. PMID 19616593 DOI: 10.1016/J.Jbiotec.2009.07.009  0.311
2009 Wolkenhauer O, Fell D, De Meyts P, Blüthgen N, Herzel H, Le Novère N, Höfer T, Schürrle K, van Leeuwen I. SysBioMed report: advancing systems biology for medical applications. Iet Systems Biology. 3: 131-6. PMID 19449974 DOI: 10.1049/Iet-Syb.2009.0005  0.306
2009 Salazar C, Höfer T. Multisite protein phosphorylation - From molecular mechanisms to kinetic models Febs Journal. 276: 3177-3198. PMID 19438722 DOI: 10.1111/J.1742-4658.2009.07027.X  0.315
2009 Schulz EG, Mariani L, Radbruch A, Höfer T. Sequential Polarization and Imprinting of Type 1 T Helper Lymphocytes by Interferon-γ and Interleukin-12 Immunity. 30: 673-683. PMID 19409816 DOI: 10.1016/J.Immuni.2009.03.013  0.316
2007 Scheffold A, Murphy KM, Höfer T. Competition for cytokines: T(reg) cells take all. Nature Immunology. 8: 1285-7. PMID 18026078 DOI: 10.1038/Ni1207-1285  0.358
2007 Podtschaske M, Benary U, Zwinger S, Höfer T, Radbruch A, Baumgrass R. Digital NFATc2 Activation per Cell Transforms Graded T Cell Receptor Activation into an All-or-None IL-2 Expression Plos One. 2. PMID 17895976 DOI: 10.1371/Journal.Pone.0000935  0.35
2007 Salazar C, Höfer T. Versatile regulation of multisite protein phosphorylation by the order of phosphate processing and protein-protein interactions Febs Journal. 274: 1046-1061. PMID 17257173 DOI: 10.1111/J.1742-4658.2007.05653.X  0.307
2007 Höfer T. In Remembrance: Reinhart Heinrich 1946–2006 Plos Computational Biology. 3. DOI: 10.1371/Journal.Pcbi.0030018  0.314
2006 Salazar C, Höfer T. Competition effects shape the response sensitivity and kinetics of phosphorylation cycles in cell signaling Annals of the New York Academy of Sciences. 1091: 517-530. PMID 17341641 DOI: 10.1196/Annals.1378.093  0.329
2006 Serfling E, Chuvpilo S, Liu J, Höfer T, Palmetshofer A. NFATc1 autoregulation: a crucial step for cell-fate determination. Trends in Immunology. 27: 461-9. PMID 16931157 DOI: 10.1016/J.It.2006.08.005  0.361
2006 Höfer T, Muehlinghaus G, Moser K, Yoshida T, Mei HE, Hebel K, Hauser A, Hoyer B, Luger EO, Dörner T, Manz RA, Hiepe F, Radbruch A. Adaptation of humoral memory. Immunological Reviews. 211: 295-302. PMID 16824136 DOI: 10.1111/J.0105-2896.2006.00380.X  0.306
2006 Salazar C, Höfer T. Kinetic models of phosphorylation cycles: A systematic approach using the rapid-equilibrium approximation for protein-protein interactions Biosystems. 83: 195-206. PMID 16233950 DOI: 10.1016/J.Biosystems.2005.05.015  0.305
2004 Mariani L, Löhning M, Radbruch A, Höfer T. Transcriptional control networks of cell differentiation: insights from helper T lymphocytes. Progress in Biophysics & Molecular Biology. 86: 45-76. PMID 15261525 DOI: 10.1016/J.Pbiomolbio.2004.02.007  0.354
2003 Salazar C, Höfer T. Allosteric regulation of the transcription factor NFAT1 by multiple phosphorylation sites: A mathematical analysis Journal of Molecular Biology. 327: 31-45. PMID 12614606 DOI: 10.1016/S0022-2836(03)00085-8  0.301
2002 Höfer T, Nathansen H, Löhning M, Radbruch A, Heinrich R. GATA-3 transcriptional imprinting in Th2 lymphocytes: a mathematical model. Proceedings of the National Academy of Sciences of the United States of America. 99: 9364-8. PMID 12087127 DOI: 10.1073/Pnas.142284699  0.301
1999 Höfer T. Chemotaxis and aggregation in the cellular slime mould Lecture Notes in Physics. 137-150. DOI: 10.1007/Bfb0104224  0.377
1997 Höfer T, Maini PK. Streaming instability of slime mold amoebae: An analytical model Physical Review E. 56: 2074-2080. DOI: 10.1103/Physreve.56.2074  0.547
1996 Höfer T, Maini PK. Turing patterns in fish skin? Nature. 380: 678-678. DOI: 10.1038/380678A0  0.402
1995 HÖFER T, MAINI PK, SHERRATT JA, CHAPLAIN MAJ, MURRAY JD. RESOLVING THE CHEMOTACTIC WAVE PARADOX: A MATHEMATICAL MODEL FOR CHEMOTAXIS OF DICTYOSTELIUM AMOEBAE Journal of Biological Systems. 3: 967-973. DOI: 10.1142/S0218339095000861  0.613
1995 Höfer T, Sherratt JA, Maini PK. Cellular pattern formation during Dictyostelium aggregation Physica D: Nonlinear Phenomena. 85: 425-444. DOI: 10.1016/0167-2789(95)00075-F  0.552
1994 Höfer T, Maini PK, Sherratt JA, Chaplain MAJ, Chauvet P, Metevier D, Montes PC, Murray JD. A resolution of the chemotactic wave paradox Applied Mathematics Letters. 7: 1-5. DOI: 10.1016/0893-9659(94)90020-5  0.571
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