Kelvin Luk - Publications

Affiliations: 
McGill University, Montreal, QC, Canada 

59 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2022 Zhao J, Pan B, Fina M, Huang Y, Shimogawa M, Luk KC, Rhoades E, Petersson EJ, Dong DW, Kashina A. α-Synuclein arginylation in the human brain. Translational Neurodegeneration. 11: 20. PMID 35395956 DOI: 10.1186/s40035-022-00295-0  0.338
2021 Steinkellner T, Conrad WS, Kovacs I, Rissman RA, Lee EB, Trojanowski JQ, Freyberg Z, Roy S, Luk KC, Lee VM, Hnasko TS. Dopamine neurons exhibit emergent glutamatergic identity in Parkinson's disease. Brain : a Journal of Neurology. PMID 35258081 DOI: 10.1093/brain/awab373  0.301
2021 Johnson ME, Bergkvist L, Stetzik L, Steiner JA, Meyerdirk L, Schulz E, Wolfrum E, Luk KC, Wesson DW, Krainc D, Brundin P. Heterozygous GBA D490V and ATP13a2 mutations do not exacerbate pathological α-synuclein spread in the prodromal preformed fibrils model in young mice. Neurobiology of Disease. 105513. PMID 34536552 DOI: 10.1016/j.nbd.2021.105513  0.302
2021 Emmenegger M, De Cecco E, Hruska-Plochan M, Eninger T, Schneider MM, Barth M, Tantardini E, de Rossi P, Bacioglu M, Langston RG, Kaganovich A, Bengoa-Vergniory N, Gonzalez-Guerra A, Avar M, Heinzer D, ... ... Luk K, et al. LAG3 is not expressed in human and murine neurons and does not modulate α-synucleinopathies. Embo Molecular Medicine. e14745. PMID 34309222 DOI: 10.15252/emmm.202114745  0.394
2021 Puentes LN, Lengyel-Zhand Z, Lee JY, Hsieh CJ, Schneider ME, Edwards KJ, Luk KC, Lee VM, Trojanowski JQ, Mach RH. Poly (ADP-ribose) Interacts With Phosphorylated α-Synuclein in Post Mortem PD Samples. Frontiers in Aging Neuroscience. 13: 704041. PMID 34220490 DOI: 10.3389/fnagi.2021.704041  0.34
2021 Howe JW, Sortwell CE, Duffy MF, Kemp CJ, Russell CP, Kubik M, Patel P, Luk KC, El-Agnaf OMA, Patterson JR. Preformed fibrils generated from mouse alpha-synuclein produce more inclusion pathology in rats than fibrils generated from rat alpha-synuclein. Parkinsonism & Related Disorders. 89: 41-47. PMID 34218047 DOI: 10.1016/j.parkreldis.2021.06.010  0.379
2021 Albert K, Raymundo DP, Panhelainen A, Eesmaa A, Shvachiy L, Araújo GR, Chmielarz P, Yan X, Singh A, Cordeiro Y, Palhano FL, Foguel D, Luk KC, Domanskyi A, Voutilainen MH, et al. Cerebral Dopamine Neurotrophic Factor Reduces α-Synuclein Aggregation and Propagation and Alleviates Behavioural Alterations in vivo. Molecular Therapy : the Journal of the American Society of Gene Therapy. PMID 33940158 DOI: 10.1016/j.ymthe.2021.04.035  0.435
2021 Cole TA, Zhao H, Collier TJ, Sandoval I, Sortwell CE, Steece-Collier K, Daley BF, Booms A, Lipton J, Welch M, Berman M, Jandreski L, Graham D, Weihofen A, Celano S, ... ... Luk KC, et al. α-Synuclein antisense oligonucleotides as a disease-modifying therapy for Parkinson's disease. Jci Insight. 6. PMID 33682798 DOI: 10.1172/jci.insight.135633  0.338
2021 Miller KM, Patterson JR, Kochmanski J, Kemp CJ, Stoll AC, Onyekpe CU, Cole-Strauss A, Steece-Collier K, Howe JW, Luk KC, Sortwell CE. Striatal afferent BDNF is disrupted by synucleinopathy and partially restored by STN DBS. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. PMID 33472823 DOI: 10.1523/JNEUROSCI.1952-20.2020  0.377
2020 Zhu G, Harischandra DS, Ghaisas S, Zhang P, Prall W, Huang L, Maghames C, Guo L, Luna E, Mack KL, Torrente MP, Luk KC, Shorter J, Yang X. TRIM11 Prevents and Reverses Protein Aggregation and Rescues a Mouse Model of Parkinson's Disease. Cell Reports. 33: 108418. PMID 33264628 DOI: 10.1016/j.celrep.2020.108418  0.347
2020 Jimenez-Ferrer I, Bäckström F, Dueñas-Rey A, Jewett M, Boza-Serrano A, Luk KC, Deierborg T, Swanberg M. The MHC class II transactivator modulates seeded alpha-synuclein pathology and dopaminergic neurodegeneration in an in vivo rat model of Parkinson's disease. Brain, Behavior, and Immunity. PMID 33223048 DOI: 10.1016/j.bbi.2020.10.017  0.384
2020 Wu Q, Shaikh MA, Meymand ES, Zhang B, Luk KC, Trojanowski JQ, Lee VM. Neuronal activity modulates alpha-synuclein aggregation and spreading in organotypic brain slice cultures and in vivo. Acta Neuropathologica. PMID 33021680 DOI: 10.1007/s00401-020-02227-6  0.316
2020 Chmielarz P, Er Ş, Konovalova J, Bandres L, Hlushchuk I, Albert K, Panhelainen A, Luk K, Airavaara M, Domanskyi A. GDNF/RET Signaling Pathway Activation Eliminates Lewy Body Pathology in Midbrain Dopamine Neurons. Movement Disorders : Official Journal of the Movement Disorder Society. PMID 32964492 DOI: 10.1002/Mds.28258  0.464
2020 Kulkarni AS, Del Mar Cortijo M, Roberts ER, Suggs TL, Stover HB, Pena-Bravo JI, Steiner JA, Luk KC, Brundin P, Wesson DW. Perturbation of in vivo Neural Activity Following α-Synuclein Seeding in the Olfactory Bulb. Journal of Parkinson's Disease. PMID 32925105 DOI: 10.3233/JPD-202241  0.406
2020 Schaser AJ, Stackhouse TL, Weston LJ, Kerstein PC, Osterberg VR, López CS, Dickson DW, Luk KC, Meshul CK, Woltjer RL, Unni VK. Trans-synaptic and retrograde axonal spread of Lewy pathology following pre-formed fibril injection in an in vivo A53T alpha-synuclein mouse model of synucleinopathy. Acta Neuropathologica Communications. 8: 150. PMID 32859276 DOI: 10.1186/S40478-020-01026-0  0.362
2020 Caputo A, Liang Y, Raabe TD, Lo A, Horvath M, Zhang B, Brown HJ, Stieber A, Luk KC. -GFP knock-in mice reflect patterns of endogenous expression and pathological seeding. Eneuro. PMID 32788297 DOI: 10.1523/ENEURO.0007-20.2020  0.329
2020 Hoban DB, Shrigley S, Mattsson B, Breger LS, Jarl U, Cardoso T, Nelander Wahlestedt J, Luk KC, Björklund A, Parmar M. Impact of α-synuclein pathology on transplanted hESC-derived dopaminergic neurons in a humanized α-synuclein rat model of PD. Proceedings of the National Academy of Sciences of the United States of America. PMID 32541058 DOI: 10.1073/Pnas.2001305117  0.417
2020 Gezer AO, Kochmanski J, VanOeveren SE, Cole-Strauss A, Kemp CJ, Patterson JR, Miller KM, Kuhn NC, Herman DE, McIntire A, Lipton JW, Luk KC, Fleming SM, Sortwell CE, Bernstein AI. Developmental exposure to the organochlorine pesticide dieldrin causes male-specific exacerbation of α-synuclein-preformed fibril-induced toxicity and motor deficits. Neurobiology of Disease. 104947. PMID 32422283 DOI: 10.1016/J.Nbd.2020.104947  0.336
2020 Uemura N, Uemura MT, Luk KC, Lee VM, Trojanowski JQ. Cell-to-Cell Transmission of Tau and α-Synuclein. Trends in Molecular Medicine. PMID 32371172 DOI: 10.1016/J.Molmed.2020.03.012  0.305
2019 Henderson MX, Covell DJ, Chung CH, Pitkin RM, Sandler RM, Decker SC, Riddle DM, Zhang B, Gathagan RJ, James MJ, Trojanowski JQ, Brunden KR, Lee VMY, Luk KC. Characterization of novel conformation-selective α-synuclein antibodies as potential immunotherapeutic agents for Parkinson's disease. Neurobiology of Disease. 104712. PMID 31837422 DOI: 10.1016/J.Nbd.2019.104712  0.415
2019 Chu Y, Muller S, Tavares A, Barret O, Alagille D, Seibyl J, Tamagnan G, Marek K, Luk KC, Trojanowski JQ, Lee VMY, Kordower JH. Intrastriatal alpha-synuclein fibrils in monkeys: spreading, imaging and neuropathological changes. Brain : a Journal of Neurology. PMID 31580415 DOI: 10.1093/Brain/Awz296  0.435
2019 Uemura N, Uemura MT, Lo A, Bassil F, Zhang B, Luk KC, Lee VM, Takahashi R, Trojanowski JQ. Slow Progressive Accumulation of Oligodendroglial Alpha-Synuclein (α-Syn) Pathology in Synthetic α-Syn Fibril-Induced Mouse Models of Synucleinopathy. Journal of Neuropathology and Experimental Neurology. PMID 31504665 DOI: 10.1093/Jnen/Nlz070  0.414
2019 Wong YC, Luk K, Purtell K, Burke Nanni S, Stoessl AJ, Trudeau LE, Yue Z, Krainc D, Oertel W, Obeso JA, Volpicelli-Daley LA. Neuronal vulnerability in Parkinson disease: Should the focus be on axons and synaptic terminals? Movement Disorders : Official Journal of the Movement Disorder Society. PMID 31483900 DOI: 10.1002/Mds.27823  0.365
2019 Luk KC. Oxidative stress and α-synuclein conspire in vulnerable neurons to promote Parkinson's disease progression. The Journal of Clinical Investigation. 130. PMID 31380806 DOI: 10.1172/JCI130351  0.409
2019 Patterson JR, Duffy MF, Kemp CJ, Howe JW, Collier TJ, Stoll AC, Miller KM, Patel P, Levine N, Moore DJ, Luk KC, Fleming SM, Kanaan NM, Paumier KL, El-Agnaf OMA, et al. Time course and magnitude of alpha-synuclein inclusion formation and nigrostriatal degeneration in the rat model of synucleinopathy triggered by intrastriatal α-synuclein preformed fibrils. Neurobiology of Disease. 104525. PMID 31276792 DOI: 10.1016/J.Nbd.2019.104525  0.427
2019 Patterson JR, Polinski NK, Duffy MF, Kemp CJ, Luk KC, Volpicelli-Daley LA, Kanaan NM, Sortwell CE. Generation of Alpha-Synuclein Preformed Fibrils from Monomers and Use In Vivo. Journal of Visualized Experiments : Jove. PMID 31205308 DOI: 10.3791/59758  0.369
2019 Zhang B, Kehm V, Gathagan R, Leight SN, Trojanowski JQ, Lee VM, Luk KC. Stereotaxic Targeting of Alpha-Synuclein Pathology in Mouse Brain Using Preformed Fibrils. Methods in Molecular Biology (Clifton, N.J.). 1948: 45-57. PMID 30771169 DOI: 10.1007/978-1-4939-9124-2_5  0.41
2018 Ugras S, Daniels MJ, Fazelinia H, Gould NS, Yocum AK, Luk KC, Luna E, Ding H, McKennan C, Seeholzer S, Martinez D, Evans P, Brown D, Duda JE, Ischiropoulos H. Induction of the Immunoproteasome Subunit Lmp7 Links Proteostasis and Immunity in α-Synuclein Aggregation Disorders. Ebiomedicine. PMID 29759483 DOI: 10.1016/J.Ebiom.2018.05.007  0.382
2018 Peng C, Gathagan RJ, Covell DJ, Medellin C, Stieber A, Robinson JL, Zhang B, Pitkin RM, Olufemi MF, Luk KC, Trojanowski JQ, Lee VM. Cellular milieu imparts distinct pathological α-synuclein strains in α-synucleinopathies. Nature. PMID 29743672 DOI: 10.1038/S41586-018-0104-4  0.371
2018 Duffy MF, Collier TJ, Patterson JR, Kemp CJ, Luk KC, Tansey MG, Paumier KL, Kanaan NM, Fischer LD, Polinski NK, Barth OL, Howe JW, Vaikath NN, Majbour NK, El-Agnaf OMA, et al. Lewy body-like alpha-synuclein inclusions trigger reactive microgliosis prior to nigral degeneration. Journal of Neuroinflammation. 15: 129. PMID 29716614 DOI: 10.1186/S12974-018-1171-Z  0.358
2018 Luna E, Decker SC, Riddle DM, Caputo A, Zhang B, Cole T, Caswell C, Xie SX, Lee VMY, Luk KC. Differential α-synuclein expression contributes to selective vulnerability of hippocampal neuron subpopulations to fibril-induced toxicity. Acta Neuropathologica. PMID 29502200 DOI: 10.1007/S00401-018-1829-8  0.386
2018 Polinski NK, Volpicelli-Daley LA, Sortwell CE, Luk KC, Cremades N, Gottler LM, Froula J, Duffy MF, Lee VM, Martinez TN, Dave KD. Best Practices for Generating and Using Alpha-Synuclein Pre-Formed Fibrils to Model Parkinson's Disease in Rodents. Journal of Parkinson's Disease. PMID 29400668 DOI: 10.3233/Jpd-171248  0.32
2018 Manfredsson FP, Luk KC, Benskey MJ, Guezer A, Garcia J, Kuhn NC, Sandoval IM, Patterson JR, O'Mara A, Yonkers R, Kordower JH. Induction of alpha-synuclein pathology in the enteric nervous system of the rat and non-human primate results in gastrointestinal dysmotility and transient CNS pathology. Neurobiology of Disease. PMID 29341898 DOI: 10.1016/J.Nbd.2018.01.008  0.421
2017 Rey NL, George S, Steiner JA, Madaj Z, Luk KC, Trojanowski JQ, Lee VM, Brundin P. Spread of aggregates after olfactory bulb injection of α-synuclein fibrils is associated with early neuronal loss and is reduced long term. Acta Neuropathologica. PMID 29209768 DOI: 10.1007/S00401-017-1792-9  0.425
2017 Nouraei N, Mason DM, Miner KM, Carcella MA, Bhatia TN, Dumm BK, Soni D, Johnson DA, Luk KC, Leak RK. Critical appraisal of pathology transmission in the α-synuclein fibril model of Lewy body disorders. Experimental Neurology. PMID 29056362 DOI: 10.1016/J.Expneurol.2017.10.017  0.374
2017 Thakur P, Breger LS, Lundblad M, Wan OW, Mattsson B, Luk KC, Lee VMY, Trojanowski JQ, Björklund A. Modeling Parkinson's disease pathology by combination of fibril seeds and α-synuclein overexpression in the rat brain. Proceedings of the National Academy of Sciences of the United States of America. PMID 28900002 DOI: 10.1073/Pnas.1710442114  0.436
2017 Haenseler W, Zambon F, Lee H, Vowles J, Rinaldi F, Duggal G, Houlden H, Gwinn K, Wray S, Luk KC, Wade-Martins R, James WS, Cowley SA. Excess α-synuclein compromises phagocytosis in iPSC-derived macrophages. Scientific Reports. 7: 9003. PMID 28827786 DOI: 10.1038/S41598-017-09362-3  0.316
2017 Tapias V, Hu X, Luk KC, Sanders LH, Lee VM, Timothy Greenamyre J. Synthetic alpha-synuclein fibrils cause mitochondrial impairment and selective dopamine neurodegeneration in part via iNOS-mediated nitric oxide production. Cellular and Molecular Life Sciences : Cmls. PMID 28534083 DOI: 10.1007/S00018-017-2541-X  0.445
2016 Luk KC, Covell DJ, Kehm VM, Zhang B, Song IY, Byrne MD, Pitkin RM, Decker SC, Trojanowski JQ, Lee VM. Molecular and Biological Compatibility with Host Alpha-Synuclein Influences Fibril Pathogenicity. Cell Reports. 16: 3373-87. PMID 27653697 DOI: 10.1016/J.Celrep.2016.08.053  0.382
2016 Rey NL, Steiner JA, Maroof N, Luk KC, Madaj Z, Trojanowski JQ, Lee VM, Brundin P. Widespread transneuronal propagation of α-synucleinopathy triggered in olfactory bulb mimics prodromal Parkinson's disease. The Journal of Experimental Medicine. PMID 27503075 DOI: 10.1084/Jem.20160368  0.409
2015 Luna E, Luk KC. Bent out of shape: α-Synuclein misfolding and the convergence of pathogenic pathways in Parkinson's disease. Febs Letters. 589: 3749-59. PMID 26505673 DOI: 10.1016/j.febslet.2015.10.023  0.436
2015 Paumier KL, Luk KC, Manfredsson FP, Kanaan NM, Lipton JW, Collier TJ, Steece-Collier K, Kemp CJ, Celano S, Schulz E, Sandoval IM, Fleming S, Dirr E, Polinski NK, Trojanowski JQ, et al. Intrastriatal injection of pre-formed mouse α-synuclein fibrils into rats triggers α-synuclein pathology and bilateral nigrostriatal degeneration. Neurobiology of Disease. 82: 185-199. PMID 26093169 DOI: 10.1016/J.Nbd.2015.06.003  0.396
2015 Osterberg VR, Spinelli KJ, Weston LJ, Luk KC, Woltjer RL, Unni VK. Progressive aggregation of alpha-synuclein and selective degeneration of lewy inclusion-bearing neurons in a mouse model of parkinsonism. Cell Reports. 10: 1252-60. PMID 25732816 DOI: 10.1016/j.celrep.2015.01.060  0.385
2014 Volpicelli-Daley LA, Luk KC, Lee VM. Addition of exogenous α-synuclein preformed fibrils to primary neuronal cultures to seed recruitment of endogenous α-synuclein to Lewy body and Lewy neurite-like aggregates. Nature Protocols. 9: 2135-46. PMID 25122523 DOI: 10.1038/Nprot.2014.143  0.4
2014 Tran HT, Chung CH, Iba M, Zhang B, Trojanowski JQ, Luk KC, Lee VM. Α-synuclein immunotherapy blocks uptake and templated propagation of misfolded α-synuclein and neurodegeneration. Cell Reports. 7: 2054-65. PMID 24931606 DOI: 10.1016/J.Celrep.2014.05.033  0.43
2013 Luk KC, Rymar VV, van den Munckhof P, Nicolau S, Steriade C, Bifsha P, Drouin J, Sadikot AF. The transcription factor Pitx3 is expressed selectively in midbrain dopaminergic neurons susceptible to neurodegenerative stress. Journal of Neurochemistry. 125: 932-43. PMID 23331067 DOI: 10.1111/Jnc.12160  0.637
2012 Luk KC, Kehm V, Carroll J, Zhang B, O'Brien P, Trojanowski JQ, Lee VM. Pathological α-synuclein transmission initiates Parkinson-like neurodegeneration in nontransgenic mice. Science (New York, N.Y.). 338: 949-53. PMID 23161999 DOI: 10.1126/Science.1227157  0.429
2012 Luk KC, Kehm VM, Zhang B, O'Brien P, Trojanowski JQ, Lee VM. Intracerebral inoculation of pathological α-synuclein initiates a rapidly progressive neurodegenerative α-synucleinopathy in mice. The Journal of Experimental Medicine. 209: 975-86. PMID 22508839 DOI: 10.1084/Jem.20112457  0.391
2011 Volpicelli-Daley LA, Luk KC, Patel TP, Tanik SA, Riddle DM, Stieber A, Meaney DF, Trojanowski JQ, Lee VM. Exogenous α-synuclein fibrils induce Lewy body pathology leading to synaptic dysfunction and neuron death. Neuron. 72: 57-71. PMID 21982369 DOI: 10.1016/J.Neuron.2011.08.033  0.416
2008 Gandhi R, Luk KC, Rymar VV, Sadikot AF. Group I mGluR5 metabotropic glutamate receptors regulate proliferation of neuronal progenitors in specific forebrain developmental domains. Journal of Neurochemistry. 104: 155-72. PMID 17944877 DOI: 10.1111/J.1471-4159.2007.04955.X  0.556
2007 Luk KC, Hyde EG, Trojanowski JQ, Lee VM. Sensitive fluorescence polarization technique for rapid screening of alpha-synuclein oligomerization/fibrillization inhibitors. Biochemistry. 46: 12522-9. PMID 17927212 DOI: 10.1021/Bi701128C  0.305
2005 Landau AM, Luk KC, Jones ML, Siegrist-Johnstone R, Young YK, Kouassi E, Rymar VV, Dagher A, Sadikot AF, Desbarats J. Defective Fas expression exacerbates neurotoxicity in a model of Parkinson's disease. The Journal of Experimental Medicine. 202: 575-81. PMID 16129703 DOI: 10.1084/Jem.20050163  0.619
2005 Flores C, Manitt C, Rodaros D, Thompson KM, Rajabi H, Luk KC, Tritsch NX, Sadikot AF, Stewart J, Kennedy TE. Netrin receptor deficient mice exhibit functional reorganization of dopaminergic systems and do not sensitize to amphetamine. Molecular Psychiatry. 10: 606-12. PMID 15534618 DOI: 10.1038/Sj.Mp.4001607  0.561
2005 Rosa-Neto P, Goertzen AL, Diksic M, Dagher A, Mzengeza S, Soucy J, Luk KC, Rymar V, Sadikot AF, Evans AC. Dopamine D2/3 receptor binding in aphakia mice measured by microPET Journal of Cerebral Blood Flow & Metabolism. 25: S604-S604. DOI: 10.1038/Sj.Jcbfm.9591524.0604  0.525
2004 Luk KC, Sadikot AF. Glutamate and regulation of proliferation in the developing mammalian telencephalon. Developmental Neuroscience. 26: 218-28. PMID 15711062 DOI: 10.1159/000082139  0.524
2004 Rymar VV, Sasseville R, Luk KC, Sadikot AF. Neurogenesis and stereological morphometry of calretinin-immunoreactive GABAergic interneurons of the neostriatum. The Journal of Comparative Neurology. 469: 325-39. PMID 14730585 DOI: 10.1002/Cne.11008  0.557
2003 van den Munckhof P, Luk KC, Ste-Marie L, Montgomery J, Blanchet PJ, Sadikot AF, Drouin J. Pitx3 is required for motor activity and for survival of a subset of midbrain dopaminergic neurons. Development (Cambridge, England). 130: 2535-42. PMID 12702666 DOI: 10.1242/Dev.00464  0.641
2003 Luk KC, Kennedy TE, Sadikot AF. Glutamate promotes proliferation of striatal neuronal progenitors by an NMDA receptor-mediated mechanism. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 23: 2239-50. PMID 12657683 DOI: 10.1523/Jneurosci.23-06-02239.2003  0.547
2001 Luk KC, Sadikot AF. GABA promotes survival but not proliferation of parvalbumin-immunoreactive interneurons in rodent neostriatum: An in vivo study with stereology Neuroscience. 104: 93-103. PMID 11311534 DOI: 10.1016/S0306-4522(01)00038-0  0.559
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