Pascual Sanz - Publications

Instituto de Biomedicina de Valencia, València, Comunidad Valenciana, Spain 

61 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2021 Vela M, García-Gimeno MA, Sanchis A, Bono-Yagüe J, Cumella J, Lagartera L, Pérez C, Priego EM, Campos A, Sanz P, Vázquez-Manrique RP, Castro A. Neuroprotective Effect of IND1316, an Indole-Based AMPK Activator, in Animal Models of Huntington Disease. Acs Chemical Neuroscience. PMID 34962383 DOI: 10.1021/acschemneuro.1c00758  0.739
2021 Brewer MK, Machio-Castello M, Viana R, Wayne JL, Kuchtová A, Simmons ZR, Sternbach S, Li S, García-Gimeno MA, Serratosa JM, Sanz P, Vander Kooi CW, Gentry MS. An empirical pipeline for personalized diagnosis of Lafora disease mutations. Iscience. 24: 103276. PMID 34755096 DOI: 10.1016/j.isci.2021.103276  0.787
2021 Kumarasinghe L, Xiong L, Garcia-Gimeno MA, Lazzari E, Sanz P, Meroni G. TRIM32 and Malin in Neurological and Neuromuscular Rare Diseases. Cells. 10. PMID 33917450 DOI: 10.3390/cells10040820  0.747
2020 Perez-Jimenez E, Viana R, Muñoz-Ballester C, Vendrell-Tornero C, Moll-Diaz R, Garcia-Gimeno MA, Sanz P. Endocytosis of the glutamate transporter 1 is regulated by laforin and malin: Implications in Lafora disease. Glia. PMID 33368637 DOI: 10.1002/glia.23956  0.763
2020 Sanz P, Garcia-Gimeno MA. Reactive Glia Inflammatory Signaling Pathways and Epilepsy. International Journal of Molecular Sciences. 21. PMID 32521797 DOI: 10.3390/ijms21114096  0.689
2020 Espinós C, Galindo MI, García-Gimeno MA, Ibáñez-Cabellos JS, Martínez-Rubio D, Millán JM, Rodrigo R, Sanz P, Seco-Cervera M, Sevilla T, Tapia A, Pallardó FV. Oxidative Stress, a Crossroad Between Rare Diseases and Neurodegeneration. Antioxidants (Basel, Switzerland). 9. PMID 32326494 DOI: 10.3390/antiox9040313  0.69
2019 Sanchez-Martin P, Lahuerta M, Viana R, Knecht E, Sanz P. Regulation of the autophagic PI3KC3 complex by laforin/malin E3-ubiquitin ligase, two proteins involved in Lafora disease. Biochimica Et Biophysica Acta. Molecular Cell Research. 1867: 118613. PMID 31758957 DOI: 10.1016/j.bbamcr.2019.118613  0.767
2019 Sanchis A, García-Gimeno MA, Cañada-Martínez AJ, Sequedo MD, Millán JM, Sanz P, Vázquez-Manrique RP. Metformin treatment reduces motor and neuropsychiatric phenotypes in the zQ175 mouse model of Huntington disease. Experimental & Molecular Medicine. 51: 65. PMID 31165723 DOI: 10.1038/s12276-019-0264-9  0.749
2019 Muñoz-Ballester C, Santana N, Perez-Jimenez E, Viana R, Artigas F, Sanz P. In vivo glutamate clearance defects in a mouse model of Lafora disease. Experimental Neurology. 112959. PMID 31108086 DOI: 10.1016/j.expneurol.2019.112959  0.733
2018 García-Gimeno MA, Knecht E, Sanz P. Lafora Disease: A Ubiquitination-Related Pathology. Cells. 7. PMID 30050012 DOI: 10.3390/cells7080087  0.774
2018 Garcia-Gimeno MA, Rodilla-Ramirez PN, Viana R, Salas-Puig X, Brewer MK, Gentry MS, Sanz P. A novel EPM2A mutation yields a slow progression form of Lafora disease. Epilepsy Research. 145: 169-177. PMID 30041081 DOI: 10.1016/J.Eplepsyres.2018.07.003  0.804
2018 Sanz P, Viana R, Garcia-Gimeno MA. AMPK Protein Interaction Analyses by Yeast Two-Hybrid. Methods in Molecular Biology (Clifton, N.J.). 1732: 143-157. PMID 29480473 DOI: 10.1007/978-1-4939-7598-3_9  0.801
2018 Rubio-Villena C, Viana R, Bonet J, Garcia-Gimeno MA, Casado M, Heredia M, Sanz P. Astrocytes: new players in progressive myoclonus epilepsy of Lafora type. Human Molecular Genetics. PMID 29408991 DOI: 10.1093/hmg/ddy044  0.759
2017 Qian J, García-Gimeno MA, Beullens M, Manzione MG, Van der Hoeven G, Igual JC, Heredia M, Sanz P, Gelens L, Bollen M. An Attachment-Independent Biochemical Timer of the Spindle Assembly Checkpoint. Molecular Cell. 68: 715-730.e5. PMID 29129638 DOI: 10.1016/j.molcel.2017.10.011  0.717
2017 López-González I, Viana R, Sanz P, Ferrer I. Inflammation in Lafora Disease: Evolution with Disease Progression in Laforin and Malin Knock-out Mouse Models. Molecular Neurobiology. 54: 3119-3130. PMID 27041370 DOI: 10.1007/s12035-016-9884-4  0.719
2016 Sanz P, Viana R, Garcia-Gimeno MA. AMPK in Yeast: The SNF1 (Sucrose Non-fermenting 1) Protein Kinase Complex. Experientia Supplementum (2012). 107: 353-374. PMID 27812987 DOI: 10.1007/978-3-319-43589-3_14  0.81
2016 Sendra L, Miguel A, Pérez-Enguix D, Herrero MJ, Montalvá E, García-Gimeno MA, Noguera I, Díaz A, Pérez J, Sanz P, López-Andújar R, Martí-Bonmatí L, Aliño SF. Studying Closed Hydrodynamic Models of "In Vivo" DNA Perfusion in Pig Liver for Gene Therapy Translation to Humans. Plos One. 11: e0163898. PMID 27695064 DOI: 10.1371/journal.pone.0163898  0.674
2016 Muñoz-Ballester C, Berthier A, Viana R, Sanz P. Homeostasis of the astrocytic glutamate transporter GLT-1 is altered in mouse models of Lafora disease. Biochimica Et Biophysica Acta. 1862: 1074-83. PMID 26976331 DOI: 10.1016/j.bbadis.2016.03.008  0.768
2016 Oligschlaeger Y, Miglianico M, Dahlmans V, Rubio-Villena C, Chanda D, García-Gimeno MA, Coumans WA, Liu Y, Voncken JW, Luiken JJ, Glatz JF, Sanz P, Neumann D. The interaction between AMPKβ2 and the PP1-targeting subunit R6 is dynamically regulated by intracellular glycogen content. The Biochemical Journal. PMID 26831516 DOI: 10.1042/BJ20151035  0.783
2015 Sánchez-Martín P, Romá-Mateo C, Viana R, Sanz P. Ubiquitin conjugating enzyme E2-N and sequestosome-1 (p62) are components of the ubiquitination process mediated by the malin-laforin E3-ubiquitin ligase complex. The International Journal of Biochemistry & Cell Biology. 69: 204-14. PMID 26546463 DOI: 10.1016/j.biocel.2015.10.030  0.744
2015 Viana R, Lujan P, Sanz P. The laforin/malin E3-ubiquitin ligase complex ubiquitinates pyruvate kinase M1/M2. Bmc Biochemistry. 16: 24. PMID 26493215 DOI: 10.1186/s12858-015-0053-6  0.741
2015 Rubio-Villena C, Sanz P, Garcia-Gimeno MA. Structure-Function Analysis of PPP1R3D, a Protein Phosphatase 1 Targeting Subunit, Reveals a Binding Motif for 14-3-3 Proteins which Regulates its Glycogenic Properties. Plos One. 10: e0131476. PMID 26114292 DOI: 10.1371/journal.pone.0131476  0.782
2015 Berthier A, Payá M, García-Cabrero AM, Ballester MI, Heredia M, Serratosa JM, Sánchez MP, Sanz P. Pharmacological Interventions to Ameliorate Neuropathological Symptoms in a Mouse Model of Lafora Disease. Molecular Neurobiology. PMID 25627694 DOI: 10.1007/s12035-015-9091-8  0.314
2013 Sánchez-Martín P, Raththagala M, Bridges TM, Husodo S, Gentry MS, Sanz P, Romá-Mateo C. Dimerization of the glucan phosphatase laforin requires the participation of cysteine 329. Plos One. 8: e69523. PMID 23922729 DOI: 10.1371/Journal.Pone.0069523  0.334
2013 Sanz P, Rubio T, Garcia-Gimeno MA. AMPKβ subunits: more than just a scaffold in the formation of AMPK complex. The Febs Journal. 280: 3723-33. PMID 23721051 DOI: 10.1111/febs.12364  0.805
2013 Rubio-Villena C, Garcia-Gimeno MA, Sanz P. Glycogenic activity of R6, a protein phosphatase 1 regulatory subunit, is modulated by the laforin-malin complex. The International Journal of Biochemistry & Cell Biology. 45: 1479-88. PMID 23624058 DOI: 10.1016/j.biocel.2013.04.019  0.792
2013 Rubio T, Vernia S, Sanz P. Sumoylation of AMPKβ2 subunit enhances AMP-activated protein kinase activity. Molecular Biology of the Cell. 24: 1801-11, S1-4. PMID 23552691 DOI: 10.1091/mbc.E12-11-0806  0.81
2013 Gentry MS, Romá-Mateo C, Sanz P. Laforin, a protein with many faces: glucan phosphatase, adapter protein, et alii. The Febs Journal. 280: 525-37. PMID 22364389 DOI: 10.1111/J.1742-4658.2012.08549.X  0.389
2012 Garcia-Haro L, Garcia-Gimeno MA, Neumann D, Beullens M, Bollen M, Sanz P. Glucose-dependent regulation of AMP-activated protein kinase in MIN6 beta cells is not affected by the protein kinase A pathway. Febs Letters. 586: 4241-7. PMID 23116618 DOI: 10.1016/j.febslet.2012.10.032  0.735
2012 Romá-Mateo C, Sanz P, Gentry MS. Deciphering the role of malin in the lafora progressive myoclonus epilepsy. Iubmb Life. 64: 801-8. PMID 22815132 DOI: 10.1002/Iub.1072  0.386
2012 Knecht E, Criado-García O, Aguado C, Gayarre J, Duran-Trio L, Garcia-Cabrero AM, Vernia S, San Millán B, Heredia M, Romá-Mateo C, Mouron S, Juana-López L, Domínguez M, Navarro C, Serratosa JM, ... ... Sanz P, et al. Malin knockout mice support a primary role of autophagy in the pathogenesis of Lafora disease. Autophagy. 8: 701-3. PMID 22361617 DOI: 10.4161/auto.19522  0.725
2012 Criado O, Aguado C, Gayarre J, Duran-Trio L, Garcia-Cabrero AM, Vernia S, San Millán B, Heredia M, Romá-Mateo C, Mouron S, Juana-López L, Domínguez M, Navarro C, Serratosa JM, Sanchez M, ... Sanz P, et al. Lafora bodies and neurological defects in malin-deficient mice correlate with impaired autophagy. Human Molecular Genetics. 21: 1521-33. PMID 22186026 DOI: 10.1093/hmg/ddr590  0.711
2012 Knecht E, Criado-García O, Aguado C, Gayarre J, Duran-Trio L, Garcia-Cabrero AM, Vernia S, San Millán B, Heredia M, Romá-Mateo C, Mouron S, Juana-López L, Domínguez M, Navarro C, Serratosa JM, ... ... Sanz P, et al. Erratum to Autophagy. 8: 1163-1163. DOI: 10.4161/AUTO.21428  0.626
2011 Dukhande VV, Rogers DM, Romá-Mateo C, Donderis J, Marina A, Taylor AO, Sanz P, Gentry MS. Laforin, a dual specificity phosphatase involved in Lafora disease, is present mainly as monomeric form with full phosphatase activity. Plos One. 6: e24040. PMID 21887368 DOI: 10.1371/Journal.Pone.0024040  0.332
2011 Romá-Mateo C, Moreno D, Vernia S, Rubio T, Bridges TM, Gentry MS, Sanz P. Lafora disease E3-ubiquitin ligase malin is related to TRIM32 at both the phylogenetic and functional level. Bmc Evolutionary Biology. 11: 225. PMID 21798009 DOI: 10.1186/1471-2148-11-225  0.803
2011 Guerrero R, Vernia S, Sanz R, Abreu-Rodríguez I, Almaraz C, García-Hoyos M, Michelucci R, Tassinari CA, Riguzzi P, Nobile C, Sanz P, Serratosa JM, Gómez-Garre P. A PTG variant contributes to a milder phenotype in Lafora disease. Plos One. 6: e21294. PMID 21738631 DOI: 10.1371/journal.pone.0021294  0.744
2011 Romá-Mateo C, Solaz-Fuster Mdel C, Gimeno-Alcañiz JV, Dukhande VV, Donderis J, Worby CA, Marina A, Criado O, Koller A, Rodriguez De Cordoba S, Gentry MS, Sanz P. Laforin, a dual-specificity phosphatase involved in Lafora disease, is phosphorylated at Ser25 by AMP-activated protein kinase. The Biochemical Journal. 439: 265-75. PMID 21728993 DOI: 10.1042/Bj20110150  0.416
2011 Couarch P, Vernia S, Gourfinkel-An I, Lesca G, Gataullina S, Fedirko E, Trouillard O, Depienne C, Dulac O, Steschenko D, Leguern E, Sanz P, Baulac S. Lafora progressive myoclonus epilepsy: NHLRC1 mutations affect glycogen metabolism. Journal of Molecular Medicine (Berlin, Germany). 89: 915-25. PMID 21505799 DOI: 10.1007/s00109-011-0758-y  0.756
2011 Vernia S, Heredia M, Criado O, Rodriguez de Cordoba S, Garcia-Roves PM, Cansell C, Denis R, Luquet S, Foufelle F, Ferre P, Sanz P. Laforin, a dual specificity phosphatase involved in Lafora disease, regulates insulin response and whole-body energy balance in mice. Human Molecular Genetics. 20: 2571-84. PMID 21493628 DOI: 10.1093/hmg/ddr157  0.686
2010 Knecht E, Aguado C, Sarkar S, Korolchuk VI, Criado-García O, Vernia S, Boya P, Sanz P, Rodríguez de Córdoba S, Rubinsztein DC. Impaired autophagy in Lafora disease. Autophagy. 6: 991-3. PMID 20818165 DOI: 10.4161/auto6.7.13308  0.706
2010 Garcia-Haro L, Garcia-Gimeno MA, Neumann D, Beullens M, Bollen M, Sanz P. The PP1-R6 protein phosphatase holoenzyme is involved in the glucose-induced dephosphorylation and inactivation of AMP-activated protein kinase, a key regulator of insulin secretion, in MIN6 beta cells. Faseb Journal : Official Publication of the Federation of American Societies For Experimental Biology. 24: 5080-91. PMID 20724523 DOI: 10.1096/fj.10-166306  0.764
2010 Moreno D, Towler MC, Hardie DG, Knecht E, Sanz P. The laforin-malin complex, involved in Lafora disease, promotes the incorporation of K63-linked ubiquitin chains into AMP-activated protein kinase beta subunits. Molecular Biology of the Cell. 21: 2578-88. PMID 20534808 DOI: 10.1091/mbc.E10-03-0227  0.33
2010 Aguado C, Sarkar S, Korolchuk VI, Criado O, Vernia S, Boya P, Sanz P, de Córdoba SR, Knecht E, Rubinsztein DC. Laforin, the most common protein mutated in Lafora disease, regulates autophagy. Human Molecular Genetics. 19: 2867-76. PMID 20453062 DOI: 10.1093/hmg/ddq190  0.728
2009 Barbetti F, Cobo-Vuilleumier N, Dionisi-Vici C, Toni S, Ciampalini P, Massa O, Rodriguez-Bada P, Colombo C, Lenzi L, Garcia-Gimeno MA, Bermudez-Silva FJ, Rodriguez de Fonseca F, Banin P, Aledo JC, Baixeras E, ... Sanz P, et al. Opposite clinical phenotypes of glucokinase disease: Description of a novel activating mutation and contiguous inactivating mutations in human glucokinase (GCK) gene. Molecular Endocrinology (Baltimore, Md.). 23: 1983-9. PMID 19884385 DOI: 10.1210/me.2009-0094  0.721
2009 Moreno D, Viana R, Sanz P. Two-hybrid analysis identifies PSMD11, a non-ATPase subunit of the proteasome, as a novel interaction partner of AMP-activated protein kinase. The International Journal of Biochemistry & Cell Biology. 41: 2431-9. PMID 19616115 DOI: 10.1016/j.biocel.2009.07.002  0.751
2009 Vernia S, Rubio T, Heredia M, Rodríguez de Córdoba S, Sanz P. Increased endoplasmic reticulum stress and decreased proteasomal function in lafora disease models lacking the phosphatase laforin. Plos One. 4: e5907. PMID 19529779 DOI: 10.1371/journal.pone.0005907  0.825
2009 Vernia S, Solaz-Fuster MC, Gimeno-Alcañiz JV, Rubio T, García-Haro L, Foretz M, de Córdoba SR, Sanz P. AMP-activated protein kinase phosphorylates R5/PTG, the glycogen targeting subunit of the R5/PTG-protein phosphatase 1 holoenzyme, and accelerates its down-regulation by the laforin-malin complex. The Journal of Biological Chemistry. 284: 8247-55. PMID 19171932 DOI: 10.1074/jbc.M808492200  0.81
2008 Sanz P. AMP-activated protein kinase: structure and regulation. Current Protein & Peptide Science. 9: 478-92. PMID 18855699  0.322
2008 Riera A, Ahuatzi D, Herrero P, Garcia-Gimeno MA, Sanz P, Moreno F. Human pancreatic beta-cell glucokinase: subcellular localization and glucose repression signalling function in the yeast cell. The Biochemical Journal. 415: 233-9. PMID 18588509 DOI: 10.1042/BJ20080797  0.701
2008 Viana R, Aguado C, Esteban I, Moreno D, Viollet B, Knecht E, Sanz P. Role of AMP-activated protein kinase in autophagy and proteasome function. Biochemical and Biophysical Research Communications. 369: 964-8. PMID 18328803 DOI: 10.1016/j.bbrc.2008.02.126  0.745
2008 Estalella I, Garcia-Gimeno MA, Marina A, Castaño L, Sanz P. Biochemical characterization of novel glucokinase mutations isolated from Spanish maturity-onset diabetes of the young (MODY2) patients. Journal of Human Genetics. 53: 460-6. PMID 18322640 DOI: 10.1007/s10038-008-0271-5  0.714
2008 Solaz-Fuster MC, Gimeno-Alcañiz JV, Ros S, Fernandez-Sanchez ME, Garcia-Fojeda B, Criado Garcia O, Vilchez D, Dominguez J, Garcia-Rocha M, Sanchez-Piris M, Aguado C, Knecht E, Serratosa J, Guinovart JJ, Sanz P, et al. Regulation of glycogen synthesis by the laforin-malin complex is modulated by the AMP-activated protein kinase pathway. Human Molecular Genetics. 17: 667-78. PMID 18029386 DOI: 10.1093/hmg/ddm339  0.416
2007 Lesage B, Beullens M, Pedelini L, Garcia-Gimeno MA, Waelkens E, Sanz P, Bollen M. A complex of catalytically inactive protein phosphatase-1 sandwiched between Sds22 and inhibitor-3. Biochemistry. 46: 8909-19. PMID 17630778 DOI: 10.1021/bi7003119  0.738
2007 Viana R, Towler MC, Pan DA, Carling D, Viollet B, Hardie DG, Sanz P. A conserved sequence immediately N-terminal to the Bateman domains in AMP-activated protein kinase gamma subunits is required for the interaction with the beta subunits. The Journal of Biological Chemistry. 282: 16117-25. PMID 17403675 DOI: 10.1074/Jbc.M611804200  0.712
2007 Pedelini L, Marquina M, Ariño J, Casamayor A, Sanz L, Bollen M, Sanz P, Garcia-Gimeno MA. YPI1 and SDS22 proteins regulate the nuclear localization and function of yeast type 1 phosphatase Glc7. The Journal of Biological Chemistry. 282: 3282-92. PMID 17142459 DOI: 10.1074/jbc.M607171200  0.763
2006 Solaz-Fuster MC, Gimeno-Alcañiz JV, Casado M, Sanz P. TRIP6 transcriptional co-activator is a novel substrate of AMP-activated protein kinase. Cellular Signalling. 18: 1702-12. PMID 16624523 DOI: 10.1016/j.cellsig.2006.01.021  0.327
2005 Pedelini L, Garcia-Gimeno MA, Marina A, Gomez-Zumaquero JM, Rodriguez-Bada P, López-Enriquez S, Soriguer FC, Cuesta-Muñoz AL, Sanz P. Structure-function analysis of the alpha5 and the alpha13 helices of human glucokinase: description of two novel activating mutations. Protein Science : a Publication of the Protein Society. 14: 2080-6. PMID 15987895 DOI: 10.1110/ps.051485205  0.709
2005 Tomás-Cobos L, Viana R, Sanz P. TOR kinase pathway and 14-3-3 proteins regulate glucose-induced expression of HXT1, a yeast low-affinity glucose transporter. Yeast (Chichester, England). 22: 471-9. PMID 15849787 DOI: 10.1002/yea.1224  0.731
2004 Cuesta-Muñoz AL, Huopio H, Otonkoski T, Gomez-Zumaquero JM, Näntö-Salonen K, Rahier J, López-Enriquez S, García-Gimeno MA, Sanz P, Soriguer FC, Laakso M. Severe persistent hyperinsulinemic hypoglycemia due to a de novo glucokinase mutation. Diabetes. 53: 2164-8. PMID 15277402 DOI: 10.2337/diabetes.53.8.2164  0.731
2003 Fernández-Sánchez ME, Criado-García O, Heath KE, García-Fojeda B, Medraño-Fernández I, Gomez-Garre P, Sanz P, Serratosa JM, Rodríguez de Córdoba S. Laforin, the dual-phosphatase responsible for Lafora disease, interacts with R5 (PTG), a regulatory subunit of protein phosphatase-1 that enhances glycogen accumulation. Human Molecular Genetics. 12: 3161-71. PMID 14532330 DOI: 10.1093/hmg/ddg340  0.356
2003 García-Gimeno MA, Muñoz I, Ariño J, Sanz P. Molecular characterization of Ypi1, a novel Saccharomyces cerevisiae type 1 protein phosphatase inhibitor. The Journal of Biological Chemistry. 278: 47744-52. PMID 14506263 DOI: 10.1074/jbc.M306157200  0.75
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