| Year |
Citation |
Score |
| 2023 |
Kim E, Kim H, Jedrychowski MP, Bakiasi G, Park J, Kruskop J, Choi Y, Kwak SS, Quinti L, Kim DY, Wrann CD, Spiegelman BM, Tanzi RE, Choi SH. Irisin reduces amyloid-β by inducing the release of neprilysin from astrocytes following downregulation of ERK-STAT3 signaling. Neuron. PMID 37689059 DOI: 10.1016/j.neuron.2023.08.012 |
0.788 |
|
| 2023 |
Jorfi M, Park J, Hall CK, Lin CJ, Chen M, von Maydell D, Kruskop JM, Kang B, Choi Y, Prokopenko D, Irimia D, Kim DY, Tanzi RE. Infiltrating CD8 T cells exacerbate Alzheimer's disease pathology in a 3D human neuroimmune axis model. Nature Neuroscience. PMID 37620442 DOI: 10.1038/s41593-023-01415-3 |
0.782 |
|
| 2023 |
Boyarko B, Podvin S, Greenberg B, Momper JD, Huang Y, Gerwick WH, Bang AG, Quinti L, Griciuc A, Kim DY, Tanzi RE, Feldman HH, Hook V. Evaluation of bumetanide as a potential therapeutic agent for Alzheimer's disease. Frontiers in Pharmacology. 14: 1190402. PMID 37601062 DOI: 10.3389/fphar.2023.1190402 |
0.664 |
|
| 2023 |
Wittrahm R, Takalo M, Kuulasmaa T, Mäkinen PM, Mäkinen P, Končarević S, Fartzdinov V, Selzer S, Kokkola T, Antikainen L, Martiskainen H, Kemppainen S, Marttinen M, Jeskanen H, Rostalski H, ... ... Kim DY, et al. Protective Alzheimer's disease-associated APP A673T variant predominantly decreases sAPPβ levels in cerebrospinal fluid and 2D/3D cell culture models. Neurobiology of Disease. 106140. PMID 37120095 DOI: 10.1016/j.nbd.2023.106140 |
0.689 |
|
| 2023 |
Hebisch M, Klostermeier S, Wolf K, Boccaccini AR, Wolf SE, Tanzi RE, Kim DY. The Impact of the Cellular Environment and Aging on Modeling Alzheimer's Disease in 3D Cell Culture Models. Advanced Science (Weinheim, Baden-Wurttemberg, Germany). e2205037. PMID 36642841 DOI: 10.1002/advs.202205037 |
0.681 |
|
| 2022 |
Ning S, Jorfi M, Patel SR, Kim DY, Tanzi RE. Neurotechnological Approaches to the Diagnosis and Treatment of Alzheimer's Disease. Frontiers in Neuroscience. 16: 854992. PMID 35401082 DOI: 10.3389/fnins.2022.854992 |
0.795 |
|
| 2021 |
Kim JJ, Jorfi M, Tanzi RE, Kim DY, Doyle PS, Irimia D. Patterning of interconnected human brain spheroids. Lab On a Chip. PMID 34286713 DOI: 10.1039/d0lc01112f |
0.814 |
|
| 2020 |
Chun H, Im H, Kang YJ, Kim Y, Shin JH, Won W, Lim J, Ju Y, Park YM, Kim S, Lee SE, Lee J, Woo J, Hwang Y, Cho H, ... ... Kim D, ... ... Kim DY, et al. Severe reactive astrocytes precipitate pathological hallmarks of Alzheimer's disease via HO production. Nature Neuroscience. PMID 33199896 DOI: 10.1038/s41593-020-00735-y |
0.436 |
|
| 2020 |
Cenini G, Hebisch M, Iefremova V, Flitsch LJ, Breitkreuz Y, Tanzi RE, Kim DY, Peitz M, Brüstle O. Dissecting Alzheimer's disease pathogenesis in human 2D and 3D models. Molecular and Cellular Neurosciences. 103568. PMID 33068718 DOI: 10.1016/j.mcn.2020.103568 |
0.681 |
|
| 2020 |
Kwak SS, Washicosky KJ, Brand E, von Maydell D, Aronson J, Kim S, Capen DE, Cetinbas M, Sadreyev R, Ning S, Bylykbashi E, Xia W, Wagner SL, Choi SH, Tanzi RE, ... Kim DY, et al. Amyloid-β42/40 ratio drives tau pathology in 3D human neural cell culture models of Alzheimer's disease. Nature Communications. 11: 1377. PMID 32170138 DOI: 10.1038/S41467-020-15120-3 |
0.742 |
|
| 2019 |
Shin Y, Choi SH, Kim E, Bylykbashi E, Kim JA, Chung S, Kim DY, Kamm RD, Tanzi RE. Blood-Brain Barrier Dysfunction in a 3D In Vitro Model of Alzheimer's Disease. Advanced Science (Weinheim, Baden-Wurttemberg, Germany). 6: 1900962. PMID 31637161 DOI: 10.1002/Advs.201900962 |
0.712 |
|
| 2019 |
Chun H, Kim Y, Kang YJ, Im H, Shin JH, Ju Y, Won W, Park YM, Lim J, Lee J, Woo J, Hwang Y, Jo S, Wetzel I, Park J, ... Kim D, ... ... Kim DY, et al. Severe reactive astrocytes precipitate pathological hallmarks of Alzheimer's disease via excessive H2O2-production Ibro Reports. 6: S118. DOI: 10.1016/J.Ibror.2019.07.377 |
0.436 |
|
| 2019 |
Ning S, Rompala A, Shanmugam NK, Kim I, Rodriguez AS, Hartmann S, Patel SR, Choi SH, Tanzi RE, Kim DY. Rapid removal of amyloid-β aggregates using superparamagnetic nanoparticles Ibro Reports. 6: S378. DOI: 10.1016/J.Ibror.2019.07.1202 |
0.587 |
|
| 2018 |
Norambuena A, Wallrabe H, Cao R, Wang DB, Silva A, Svindrych Z, Periasamy A, Hu S, Tanzi RE, Kim DY, Bloom GS. A novel lysosome-to-mitochondria signaling pathway disrupted by amyloid-β oligomers. The Embo Journal. PMID 30348864 DOI: 10.15252/Embj.2018100241 |
0.669 |
|
| 2018 |
Choi SH, Bylykbashi E, Chatila ZK, Lee SW, Pulli B, Clemenson GD, Kim E, Rompala A, Oram MK, Asselin C, Aronson J, Zhang C, Miller SJ, Lesinski A, Chen JW, ... Kim DY, et al. Combined adult neurogenesis and BDNF mimic exercise effects on cognition in an Alzheimer's mouse model. Science (New York, N.Y.). 361. PMID 30190379 DOI: 10.1126/Science.Aan8821 |
0.631 |
|
| 2018 |
Chatila ZK, Kim E, Berlé C, Bylykbashi E, Rompala A, Oram MK, Gupta D, Kwak SS, Kim YH, Kim DY, Choi SH, Tanzi RE. BACE1 Regulates Proliferation and Neuronal Differentiation of Newborn Cells in the Adult Hippocampus in Mice. Eneuro. 5. PMID 30079376 DOI: 10.1523/ENEURO.0067-18.2018 |
0.626 |
|
| 2018 |
Yu YJ, Kim YH, Na K, Min SY, Hwang OK, Park DK, Kim DY, Choi SH, Kamm RD, Chung S, Kim JA. Hydrogel-incorporating unit in a well: 3D cell culture for high-throughput analysis. Lab On a Chip. PMID 30043033 DOI: 10.1039/C8Lc00525G |
0.448 |
|
| 2018 |
Park J, Wetzel I, Marriott I, Dréau D, D'Avanzo C, Kim DY, Tanzi RE, Cho H. A 3D human triculture system modeling neurodegeneration and neuroinflammation in Alzheimer's disease. Nature Neuroscience. PMID 29950669 DOI: 10.1038/S41593-018-0175-4 |
0.818 |
|
| 2018 |
Jorfi M, D'Avanzo C, Tanzi RE, Kim DY, Irimia D. Human Neurospheroid Arrays for In Vitro Studies of Alzheimer's Disease. Scientific Reports. 8: 2450. PMID 29402979 DOI: 10.1038/S41598-018-20436-8 |
0.787 |
|
| 2017 |
Gong Y, Sasidharan N, Laheji F, Frosch M, Musolino P, Tanzi R, Kim DY, Biffi A, El Khoury J, Eichler F. Microglial dysfunction as a key pathologic change in adrenomyeloneuropathy. Annals of Neurology. PMID 29059709 DOI: 10.1002/Ana.25085 |
0.306 |
|
| 2017 |
Jorfi M, D'Avanzo C, Kim DY, Irimia D. Three-Dimensional Models of the Human Brain Development and Diseases. Advanced Healthcare Materials. PMID 28845922 DOI: 10.1002/Adhm.201700723 |
0.791 |
|
| 2017 |
Wagner SL, Rynearson KD, Duddy SK, Zhang C, Nguyen PD, Becker A, Vo U, Masliah D, Monte L, Klee JB, Echmalian CM, Xia W, Quinti L, Johnson G, Lin JH, ... Kim DY, et al. Pharmacological and Toxicological Properties of the Potent Oral γ-Secretase Modulator BPN-15606. The Journal of Pharmacology and Experimental Therapeutics. PMID 28416568 DOI: 10.1124/Jpet.117.240861 |
0.656 |
|
| 2017 |
Quinti L, Forte AM, Kim DY, Griciuc A, Tanzi RE. A NOVEL DRUG-SCREENING PLATFORM IN MICROGLIAL CELLS IDENTIFIES POTENTIAL AD DRUGS Alzheimer's & Dementia. 13: P1485. DOI: 10.1016/J.Jalz.2017.07.564 |
0.599 |
|
| 2016 |
Choi SH, Kim YH, Quinti L, Tanzi RE, Kim DY. 3D culture models of Alzheimer's disease: a road map to a "cure-in-a-dish". Molecular Neurodegeneration. 11: 75. PMID 27938410 DOI: 10.1186/S13024-016-0139-7 |
0.733 |
|
| 2016 |
Tanzi R, Kim DY. EC-03-01: Reconstructing Alzheimer Amyloid and Tau Pathology in 3D Cell Cultures from Stem Cells Alzheimer's & Dementia. 12: P268-P269. DOI: 10.1016/J.Jalz.2016.06.485 |
0.688 |
|
| 2015 |
Choi SH, Kim YH, D'Avanzo C, Aronson J, Tanzi RE, Kim DY. Recapitulating amyloid β and tau pathology in human neural cell culture models: clinical implications. Us Neurology. 11: 102-105. PMID 27019672 DOI: 10.17925/Usn.2015.11.02.102 |
0.739 |
|
| 2015 |
Agsten M, Hessler S, Lehnert S, Volk T, Rittger A, Hartmann S, Raab C, Kim DY, Groemer TW, Schwake M, Alzheimer C, Huth T. BACE1 modulates gating of KCNQ1 (Kv7.1) and cardiac delayed rectifier KCNQ1/KCNE1 (IKs). Journal of Molecular and Cellular Cardiology. PMID 26454161 DOI: 10.1016/J.Yjmcc.2015.10.006 |
0.364 |
|
| 2015 |
Hyman BT, Growdon JH, Albers MW, Buckner RL, Chhatwal J, Gomez-Isla MT, Haass C, Hudry E, Jack CR, Johnson KA, Khachaturian ZS, Kim DY, Martin JB, Nitsch RM, Rosen BR, et al. Massachusetts Alzheimer's Disease Research Center: Progress and challenges. Alzheimer's & Dementia : the Journal of the Alzheimer's Association. PMID 26297855 DOI: 10.1016/J.Jalz.2015.06.1887 |
0.639 |
|
| 2015 |
D'Avanzo C, Aronson J, Kim YH, Choi SH, Tanzi RE, Kim DY. Alzheimer's in 3D culture: Challenges and perspectives. Bioessays : News and Reviews in Molecular, Cellular and Developmental Biology. 37: 1139-48. PMID 26252541 DOI: 10.1002/Bies.201500063 |
0.739 |
|
| 2015 |
Kim YH, Choi SH, D'Avanzo C, Hebisch M, Sliwinski C, Bylykbashi E, Washicosky KJ, Klee JB, Brüstle O, Tanzi RE, Kim DY. A 3D human neural cell culture system for modeling Alzheimer's disease. Nature Protocols. 10: 985-1006. PMID 26068894 DOI: 10.1038/Nprot.2015.065 |
0.738 |
|
| 2015 |
D'Avanzo C, Sliwinski C, Wagner SL, Tanzi RE, Kim DY, Kovacs DM. γ-Secretase modulators reduce endogenous amyloid β42 levels in human neural progenitor cells without altering neuronal differentiation. Faseb Journal : Official Publication of the Federation of American Societies For Experimental Biology. PMID 25903103 DOI: 10.1096/fj.15-271015 |
0.715 |
|
| 2014 |
Choi SH, Kim YH, Hebisch M, Sliwinski C, Lee S, D'Avanzo C, Chen H, Hooli B, Asselin C, Muffat J, Klee JB, Zhang C, Wainger BJ, Peitz M, Kovacs DM, ... ... Kim DY, et al. A three-dimensional human neural cell culture model of Alzheimer's disease. Nature. 515: 274-8. PMID 25307057 DOI: 10.1038/Nature13800 |
0.822 |
|
| 2014 |
Gautam V, D'Avanzo C, Hebisch M, Kovacs DM, Kim DY. BACE1 activity regulates cell surface contactin-2 levels. Molecular Neurodegeneration. 9: 4. PMID 24405708 DOI: 10.1186/1750-1326-9-4 |
0.642 |
|
| 2014 |
Kim DY, Wertz MH, Gautam V, D'Avanzo C, Bhattacharyya R, Kovacs DM. The E280A presenilin mutation reduces voltage-gated sodium channel levels in neuronal cells. Neuro-Degenerative Diseases. 13: 64-8. PMID 24217025 DOI: 10.1159/000354669 |
0.574 |
|
| 2013 |
Suh J, Choi SH, Romano DM, Gannon MA, Lesinski AN, Kim DY, Tanzi RE. ADAM10 missense mutations potentiate β-amyloid accumulation by impairing prodomain chaperone function. Neuron. 80: 385-401. PMID 24055016 DOI: 10.1016/J.Neuron.2013.08.035 |
0.661 |
|
| 2013 |
Sachse CC, Kim YH, Agsten M, Huth T, Alzheimer C, Kovacs DM, Kim DY. BACE1 and presenilin/γ-secretase regulate proteolytic processing of KCNE1 and 2, auxiliary subunits of voltage-gated potassium channels. Faseb Journal : Official Publication of the Federation of American Societies For Experimental Biology. 27: 2458-67. PMID 23504710 DOI: 10.1096/Fj.12-214056 |
0.58 |
|
| 2013 |
Kim YH, Choi SH, Wagner S, Tanzi R, Kim DY. P4-015: A novel Alzheimer's disease model based on 3D-cultured human neural progenitor cells Alzheimer's & Dementia. 9: P710-P710. DOI: 10.1016/J.Jalz.2013.05.1403 |
0.677 |
|
| 2011 |
Kim DY, Kovacs DM. Surface trafficking of sodium channels in cells and in hippocampal slices. Methods in Molecular Biology (Clifton, N.J.). 793: 351-61. PMID 21913112 DOI: 10.1007/978-1-61779-328-8_23 |
0.567 |
|
| 2011 |
Kim DY, Gersbacher MT, Inquimbert P, Kovacs DM. Reduced sodium channel Na(v)1.1 levels in BACE1-null mice. The Journal of Biological Chemistry. 286: 8106-16. PMID 21190943 DOI: 10.1074/Jbc.M110.134692 |
0.55 |
|
| 2010 |
Gersbacher MT, Kim DY, Bhattacharyya R, Kovacs DM. Identification of BACE1 cleavage sites in human voltage-gated sodium channel beta 2 subunit. Molecular Neurodegeneration. 5: 61. PMID 21182789 DOI: 10.1186/1750-1326-5-61 |
0.578 |
|
| 2010 |
Kovacs DM, Gersbacher MT, Kim DY. Alzheimer's secretases regulate voltage-gated sodium channels. Neuroscience Letters. 486: 68-72. PMID 20817076 DOI: 10.1016/J.Neulet.2010.08.048 |
0.577 |
|
| 2010 |
Zhang C, Browne A, Kim DY, Tanzi RE. Familial Alzheimer's disease mutations in presenilin 1 do not alter levels of the secreted amyloid-beta protein precursor generated by beta-secretase cleavage. Current Alzheimer Research. 7: 21-6. PMID 20205669 DOI: 10.2174/156720510790274428 |
0.657 |
|
| 2010 |
Hutter-Paier B, Huttunen HJ, Puglielli L, Eckman CB, Kim DY, Hofmeister A, Moir RD, Domnitz SB, Frosch MP, Windisch M, Kovacs DM. The ACAT Inhibitor CP-113,818 Markedly Reduces Amyloid Pathology in a Mouse Model of Alzheimer's Disease Neuron. 68: 1014. DOI: 10.1016/j.neuron.2010.11.028 |
0.426 |
|
| 2007 |
Huttunen HJ, Guénette SY, Peach C, Greco C, Xia W, Kim DY, Barren C, Tanzi RE, Kovacs DM. HtrA2 regulates beta-amyloid precursor protein (APP) metabolism through endoplasmic reticulum-associated degradation. The Journal of Biological Chemistry. 282: 28285-95. PMID 17684015 DOI: 10.1074/Jbc.M702951200 |
0.712 |
|
| 2007 |
Kim DY, Carey BW, Wang H, Ingano LA, Binshtok AM, Wertz MH, Pettingell WH, He P, Lee VM, Woolf CJ, Kovacs DM. BACE1 regulates voltage-gated sodium channels and neuronal activity. Nature Cell Biology. 9: 755-64. PMID 17576410 DOI: 10.1038/Ncb1602 |
0.598 |
|
| 2007 |
Haapasalo A, Kim DY, Carey BW, Turunen MK, Pettingell WH, Kovacs DM. Presenilin/gamma-secretase-mediated cleavage regulates association of leukocyte-common antigen-related (LAR) receptor tyrosine phosphatase with beta-catenin. The Journal of Biological Chemistry. 282: 9063-72. PMID 17259169 DOI: 10.1074/Jbc.M611324200 |
0.584 |
|
| 2007 |
Carey BW, Kim DY, Kovacs DM. Presenilin/gamma-secretase and alpha-secretase-like peptidases cleave human MHC Class I proteins. The Biochemical Journal. 401: 121-7. PMID 17150042 DOI: 10.1042/Bj20060847 |
0.538 |
|
| 2006 |
Zhang M, Haapasalo A, Kim DY, Ingano LA, Pettingell WH, Kovacs DM. Presenilin/gamma-secretase activity regulates protein clearance from the endocytic recycling compartment. Faseb Journal : Official Publication of the Federation of American Societies For Experimental Biology. 20: 1176-8. PMID 16645046 DOI: 10.1096/Fj.05-5531Fje |
0.592 |
|
| 2006 |
Norambuena A, Wallrabe H, Cao R, Wang DB, Silva A, Svindrych Z, Periasamy A, Hu S, Tanzi RE, Kim DY, Bloom GS. O2-12-02: A NOVEL LYSOSOME TO MITOCHONDRIA SIGNALING PATHWAY REGULATES MITOCHONDRIAL ACTIVITY AND IS DISRUPTED BY AMYLOID-β OLIGOMERS Alzheimer's & Dementia. 14: P650-P651. DOI: 10.1016/J.Jalz.2018.06.2707 |
0.577 |
|
| 2005 |
Kim DY, Ingano LA, Carey BW, Pettingell WH, Kovacs DM. Presenilin/gamma-secretase-mediated cleavage of the voltage-gated sodium channel beta2-subunit regulates cell adhesion and migration. The Journal of Biological Chemistry. 280: 23251-61. PMID 15833746 DOI: 10.1074/Jbc.M412938200 |
0.547 |
|
| 2005 |
Kang HJ, Yoon WJ, Moon GJ, Kim DY, Sohn S, Kwon HJ, Gwag BJ. Caspase-3-mediated cleavage of PHF-1 tau during apoptosis irrespective of excitotoxicity and oxidative stress: An implication to Alzheimer's disease Neurobiology of Disease. 18: 450-458. PMID 15755671 DOI: 10.1016/J.Nbd.2004.12.004 |
0.434 |
|
| 2004 |
Hutter-Paier B, Huttunen HJ, Puglielli L, Eckman CB, Kim DY, Hofmeister A, Moir RD, Domnitz SB, Frosch MP, Windisch M, Kovacs DM. The ACAT inhibitor CP-113,818 markedly reduces amyloid pathology in a mouse model of Alzheimer's disease. Neuron. 44: 227-38. PMID 15473963 DOI: 10.1016/J.Neuron.2004.08.043 |
0.679 |
|
| 2004 |
Kim DY, MacKenzie Ingano LA, Carey BW, Pettingell W, Kovacs DM. P4-290 Voltage-gated sodium channel beta2 subunit is processed by alpha-, beta- and gamma-secretases, generating fragments elevated in AD brains Neurobiology of Aging. 25: S557-S558. DOI: 10.1016/S0197-4580(04)81848-7 |
0.353 |
|
| 2002 |
Kim DY, Ingano LA, Kovacs DM. Nectin-1alpha, an immunoglobulin-like receptor involved in the formation of synapses, is a substrate for presenilin/gamma-secretase-like cleavage. The Journal of Biological Chemistry. 277: 49976-81. PMID 12376527 DOI: 10.1074/Jbc.M210179200 |
0.561 |
|
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