Gert Fricker - Publications

Institute for Pharmacy and Molecular Biotechnology University of Heidelberg, Germany, Heidelberg, Baden-Württemberg, Germany 

144 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2022 Puris E, Fricker G, Gynther M. Targeting Transporters for Drug Delivery to the Brain: Can We Do Better? Pharmaceutical Research. PMID 35359241 DOI: 10.1007/s11095-022-03241-x  0.361
2022 Balzer V, Poc P, Puris E, Martin S, Aliasgari M, Auriola S, Fricker G. Re-evaluation of the hCMEC/D3 based in vitro BBB model for ABC transporter studies. European Journal of Pharmaceutics and Biopharmaceutics : Official Journal of Arbeitsgemeinschaft Fur Pharmazeutische Verfahrenstechnik E.V. 173: 12-21. PMID 35227855 DOI: 10.1016/j.ejpb.2022.02.017  0.353
2020 Helms HCC, Kristensen M, Saaby L, Fricker G, Brodin B. Drug Delivery Strategies to Overcome the Blood-Brain Barrier (BBB). Handbook of Experimental Pharmacology. PMID 33367937 DOI: 10.1007/164_2020_403  0.359
2020 Bauer B, Renfro JL, Karnaky KJ, Masereeuw R, Fricker G, Cannon RE, Hartz AMS. David S. Miller: Scientist, Mentor, Friend-a tribute and thank you. Fluids and Barriers of the Cns. 17: 56. PMID 32928243 DOI: 10.1186/S12987-020-00220-5  0.319
2020 Binnefeld M, Fritz S, Balzer V, Skalická V, Witzigmann D, Kauczor HU, Fricker G, Salomon JJ. Physicochemical and biopharmaceutical characterization of novel Matrix-Liposomes. European Journal of Pharmaceutics and Biopharmaceutics : Official Journal of Arbeitsgemeinschaft Fur Pharmazeutische Verfahrenstechnik E.V. PMID 32522680 DOI: 10.1016/J.Ejpb.2020.06.001  0.379
2020 Köthe T, Martin S, Reich G, Fricker G. Dual Asymmetric Centrifugation as a Novel Method to Prepare Highly Concentrated Dispersions of PEG-b-PCL Polymersomes as Drug Carriers. International Journal of Pharmaceutics. 119087. PMID 32213299 DOI: 10.1016/J.Ijpharm.2020.119087  0.315
2019 Zaremba A, Helm F, Fricker G. Impact of Zn on ABC Transporter Function in Intact Isolated Rat Brain Microvessels, Human Brain Capillary Endothelial Cells, and in Rat in Vivo. Molecular Pharmaceutics. 16: 305-317. PMID 30422662 DOI: 10.1021/Acs.Molpharmaceut.8B00987  0.46
2019 Schmitt MV, Lienau P, Fricker G, Reichel A. Quantitation of Lysosomal Trapping of Basic Lipophilic Compounds Using In Vitro Assays and In Silico Predictions Based on the Determination of the Full pH Profile of the Endo-/Lysosomal System in Rat Hepatocytes. Drug Metabolism and Disposition: the Biological Fate of Chemicals. 47: 49-57. PMID 30409837 DOI: 10.1124/Dmd.118.084541  0.357
2018 Mahringer A, Bernd A, Miller DS, Fricker G. Arylhydrocarbon receptor ligands increase ABC transporter activity and protein expression in killifish (Fundulus heteroclitus) renal proximal tubules. Biological Chemistry. PMID 30913027 DOI: 10.1515/Hsz-2018-0425  0.506
2018 Disch L, Forsch K, Siewert B, Drewe J, Fricker G. In Vitro and In Situ Absorption and Metabolism of Sesquiterpenes from Petasites hybridus Extracts. Planta Medica. 84: 795-805. PMID 29341029 DOI: 10.1055/S-0044-100401  0.312
2017 Bernard-Gauthier V, Mossine AV, Mahringer A, Aliaga A, Bailey JJ, Shao X, Stauff J, Arteaga J, Sherman PS, Grand'Maison M, Rochon PL, Wängler B, Wängler C, Bartenstein P, Kostikov A, ... ... Fricker G, et al. Identification of 18FTRACK, a Fluorine-18-Labeled Tropomyosin Receptor Kinase (Trk) Inhibitor for PET Imaging. Journal of Medicinal Chemistry. PMID 29257860 DOI: 10.1021/Acs.Jmedchem.7B01607  0.338
2017 Greenwood J, Hammarlund-Udenaes M, Jones HC, Stitt AW, Vandenbrouke RE, Romero IA, Campbell M, Fricker G, Brodin B, Manninga H, Gaillard PJ, Schwaninger M, Webster C, Wicher KB, Khrestchatisky M. Current research into brain barriers and the delivery of therapeutics for neurological diseases: a report on CNS barrier congress London, UK, 2017. Fluids and Barriers of the Cns. 14: 31. PMID 29110676 DOI: 10.1186/S12987-017-0079-9  0.312
2017 Zaremba A, Miller DS, Fricker G. Zinc chloride rapidly stimulates efflux transporters in renal proximal tubules of killifish (Fundulus heteroclitus). Toxicology and Applied Pharmacology. PMID 28882485 DOI: 10.1016/J.Taap.2017.09.001  0.509
2017 Uhl P, Pantze S, Storck P, Parmentier J, Witzigmann D, Hofhaus G, Huwyler J, Mier W, Fricker G. Oral delivery of vancomycin by tetraether lipid liposomes. European Journal of Pharmaceutical Sciences : Official Journal of the European Federation For Pharmaceutical Sciences. 108: 111-118. PMID 28716758 DOI: 10.1016/J.Ejps.2017.07.013  0.363
2017 Bernard-Gauthier V, Bailey JJ, Mossine AV, Lindner SK, Vomacka L, Aliaga A, Shao X, Quesada CA, Sherman PS, Mahringer A, Kostikov A, Grand'Maison M, Rosa-Neto P, Soucy JP, Thiel A, ... ... Fricker G, et al. A Kinome-Wide Selective Radiolabeled TrkB/C Inhibitor for in Vitro and in Vivo Neuroimaging: Synthesis, Preclinical Evaluation and First-in-Human. Journal of Medicinal Chemistry. PMID 28696690 DOI: 10.1021/Acs.Jmedchem.7B00396  0.314
2017 Ćurić A, Möschwitzer JP, Fricker G. Development and characterization of novel highly-loaded itraconazole poly(butyl cyanoacrylate) polymeric nanoparticles. European Journal of Pharmaceutics and Biopharmaceutics : Official Journal of Arbeitsgemeinschaft Fur Pharmazeutische Verfahrenstechnik E.V. 114: 175-185. PMID 28159723 DOI: 10.1016/J.Ejpb.2017.01.014  0.351
2017 Jacobsen AC, Jensen SM, Fricker G, Brandl M, Treusch A. Archaeal lipids in oral delivery of therapeutic peptides. European Journal of Pharmaceutical Sciences : Official Journal of the European Federation For Pharmaceutical Sciences. PMID 28108360 DOI: 10.1016/J.Ejps.2016.12.036  0.314
2017 Weinheimer M, Fricker G, Burhenne J, Mylius P, Schubert R. The application of P-gp inhibiting phospholipids as novel oral bioavailability enhancers - An in vitro and in vivo comparison. European Journal of Pharmaceutical Sciences : Official Journal of the European Federation For Pharmaceutical Sciences. 108: 13-22. PMID 27590127 DOI: 10.1016/J.Ejps.2016.08.055  0.384
2017 Forsch K, Siewert B, Drewe J, Fricker G, Disch L. Sustained Release for St. John?s Wort: A Rational Idea? Journal of Bioequivalence & Bioavailability. 9. DOI: 10.4172/Jbb.1000363  0.304
2016 Tremmel R, Uhl P, Helm F, Wupperfeld D, Sauter M, Mier W, Stremmel W, Hofhaus G, Fricker G. Delivery of Copper-chelating Trientine (TETA) to the central nervous system by surface modified liposomes. International Journal of Pharmaceutics. 512: 87-95. PMID 27553779 DOI: 10.1016/J.Ijpharm.2016.08.040  0.386
2016 Mahringer A, Fricker G. ABC transporters at the blood-brain barrier. Expert Opinion On Drug Metabolism & Toxicology. 12: 499-508. PMID 26998936 DOI: 10.1517/17425255.2016.1168804  0.437
2016 Uhl P, Helm F, Hofhaus G, Brings S, Kaufman C, Leotta K, Urban S, Haberkorn U, Mier W, Fricker G. A liposomal formulation for the oral application of the investigational hepatitis B drug Myrcludex B European Journal of Pharmaceutics and Biopharmaceutics. 103: 159-166. DOI: 10.1016/J.Ejpb.2016.03.031  0.315
2015 Ćurić A, Keller BL, Reul R, Möschwitzer J, Fricker G. Development and lyophilization of itraconazole loaded poly(butylcyanoacrylate) nanospheres as a drug delivery system. European Journal of Pharmaceutical Sciences : Official Journal of the European Federation For Pharmaceutical Sciences. 78: 121-31. PMID 26171880 DOI: 10.1016/J.Ejps.2015.07.010  0.334
2015 Bernd A, Ott M, Ishikawa H, Schroten H, Schwerk C, Fricker G. Characterization of efflux transport proteins of the human choroid plexus papilloma cell line HIBCPP, a functional in vitro model of the blood-cerebrospinal fluid barrier. Pharmaceutical Research. 32: 2973-82. PMID 25986174 DOI: 10.1007/S11095-015-1679-1  0.364
2015 Helm F, Fricker G. Liposomal conjugates for drug delivery to the central nervous system. Pharmaceutics. 7: 27-42. PMID 25835091 DOI: 10.3390/Pharmaceutics7020027  0.467
2015 Kolter M, Ott M, Hauer C, Reimold I, Fricker G. Nanotoxicity of poly(n-butylcyano-acrylate) nanoparticles at the blood-brain barrier, in human whole blood and in vivo. Journal of Controlled Release : Official Journal of the Controlled Release Society. 197: 165-79. PMID 25445700 DOI: 10.1016/J.Jconrel.2014.11.005  0.37
2015 Uhl P, Fricker G, Haberkorn U, Mier W. Radionuclides in drug development. Drug Discovery Today. 20: 198-208. PMID 25304182 DOI: 10.1016/J.Drudis.2014.09.027  0.314
2015 Kiessling H, Schulz I, Haltner E, Fricker G, Stelzle M, Schütte J. Mikrofluidisches 3D-Zellkulturmodell der Blut-Hirn-Schranke Biospektrum. 21: 175-178. DOI: 10.1007/S12268-015-0558-Y  0.341
2014 Parmentier J, Hofhaus G, Thomas S, Cuesta LC, Gropp F, Schröder R, Hartmann K, Fricker G. Improved oral bioavailability of human growth hormone by a combination of liposomes containing bio-enhancers and tetraether lipids and omeprazole. Journal of Pharmaceutical Sciences. 103: 3985-3993. PMID 25332052 DOI: 10.1002/Jps.24215  0.326
2014 Heshmati N, Cheng X, Dapat E, Sassene P, Eisenbrand G, Fricker G, Müllertz A. In vitro and in vivo evaluations of the performance of an indirubin derivative, formulated in four different self-emulsifying drug delivery systems. The Journal of Pharmacy and Pharmacology. 66: 1567-75. PMID 24961657 DOI: 10.1111/Jphp.12286  0.3
2014 Jähne EA, Eigenmann DE, Culot M, Cecchelli R, Walter FR, Deli MA, Tremmel R, Fricker G, Smiesko M, Hamburger M, Oufir M. Development and validation of a LC-MS/MS method for assessment of an anti-inflammatory indolinone derivative by in vitro blood-brain barrier models. Journal of Pharmaceutical and Biomedical Analysis. 98: 235-46. PMID 24949819 DOI: 10.1016/J.Jpba.2014.05.026  0.371
2014 Noysang C, Mahringer A, Zeino M, Saeed M, Luanratana O, Fricker G, Bauer R, Efferth T. Cytotoxicity and inhibition of P-glycoprotein by selected medicinal plants from Thailand. Journal of Ethnopharmacology. 155: 633-41. PMID 24929106 DOI: 10.1016/J.Jep.2014.06.001  0.363
2014 Wängler C, Chowdhury S, Höfner G, Djurova P, Purisima EO, Bartenstein P, Wängler B, Fricker G, Wanner KT, Schirrmacher R. Shuttle-cargo fusion molecules of transport peptides and the hD2/3 receptor antagonist fallypride: a feasible approach to preserve ligand-receptor binding? Journal of Medicinal Chemistry. 57: 4368-81. PMID 24779610 DOI: 10.1021/Jm5004123  0.344
2014 Frank KJ, Westedt U, Rosenblatt KM, Hölig P, Rosenberg J, Mägerlein M, Fricker G, Brandl M. What is the mechanism behind increased permeation rate of a poorly soluble drug from aqueous dispersions of an amorphous solid dispersion? Journal of Pharmaceutical Sciences. 103: 1779-86. PMID 24764046 DOI: 10.1002/Jps.23979  0.314
2014 Gartzke D, Fricker G. Establishment of optimized MDCK cell lines for reliable efflux transport studies. Journal of Pharmaceutical Sciences. 103: 1298-304. PMID 24532159 DOI: 10.1002/Jps.23901  0.346
2014 Tajima Y, Nakagawa H, Tamura A, Kadioglu O, Satake K, Mitani Y, Murase H, Regasini LO, Bolzani Vda S, Ishikawa T, Fricker G, Efferth T. Nitensidine A, a guanidine alkaloid from Pterogyne nitens, is a novel substrate for human ABC transporter ABCB1. Phytomedicine : International Journal of Phytotherapy and Phytopharmacology. 21: 323-32. PMID 24135452 DOI: 10.1016/J.Phymed.2013.08.024  0.358
2014 Pantze SF, Parmentier J, Hofhaus G, Fricker G. Matrix liposomes: A solid liposomal formulation for oral administration European Journal of Lipid Science and Technology. 116: 1145-1154. DOI: 10.1002/Ejlt.201300409  0.309
2013 Heshmati N, Wagner B, Cheng X, Scholz T, Kansy M, Eisenbrand G, Fricker G. Physicochemical characterization and in vitro permeation of an indirubin derivative. European Journal of Pharmaceutical Sciences : Official Journal of the European Federation For Pharmaceutical Sciences. 50: 467-75. PMID 23994641 DOI: 10.1016/J.Ejps.2013.08.021  0.367
2013 Heshmati N, Cheng X, Eisenbrand G, Fricker G. Enhancement of oral bioavailability of E804 by self-nanoemulsifying drug delivery system (SNEDDS) in rats. Journal of Pharmaceutical Sciences. 102: 3792-9. PMID 23934779 DOI: 10.1002/Jps.23696  0.314
2013 Avemary J, Salvamoser JD, Peraud A, Rémi J, Noachtar S, Fricker G, Potschka H. Dynamic regulation of P-glycoprotein in human brain capillaries. Molecular Pharmaceutics. 10: 3333-41. PMID 23924183 DOI: 10.1021/Mp4001102  0.438
2013 Lenhard T, Hülsermann U, Martinez-Torres F, Fricker G, Meyding-Lamadé U. A simple method to quickly and simultaneously purify and enrich intact rat brain microcapillaries and endothelial and glial cells for ex vivo studies and cell culture. Brain Research. 1519: 9-18. PMID 23665392 DOI: 10.1016/J.Brainres.2013.05.004  0.428
2013 Buckley ST, Frank KJ, Fricker G, Brandl M. Biopharmaceutical classification of poorly soluble drugs with respect to "enabling formulations". European Journal of Pharmaceutical Sciences : Official Journal of the European Federation For Pharmaceutical Sciences. 50: 8-16. PMID 23583787 DOI: 10.1016/J.Ejps.2013.04.002  0.349
2013 Mahringer A, Ardjomand-Woelkart K, Bauer R, Fricker G, Efferth T. Alkamides from Echinacea angustifolia Interact with P-glycoprotein of primary brain capillary endothelial cells isolated from porcine brain blood vessels. Planta Medica. 79: 214-8. PMID 23322561 DOI: 10.1055/S-0032-1328090  0.436
2013 Gerbeth K, Hüsch J, Fricker G, Werz O, Schubert-Zsilavecz M, Abdel-Tawab M. In vitro metabolism, permeation, and brain availability of six major boswellic acids from Boswellia serrata gum resins. Fitoterapia. 84: 99-106. PMID 23103296 DOI: 10.1016/J.Fitote.2012.10.009  0.32
2012 Fischer SM, Parmentier J, Buckley ST, Reimold I, Brandl M, Fricker G. Oral bioavailability of ketoprofen in suspension and solution formulations in rats: The influence of poloxamer 188 Journal of Pharmacy and Pharmacology. 64: 1631-1637. PMID 23058050 DOI: 10.1111/J.2042-7158.2012.01541.X  0.348
2012 Martins S, Tho I, Reimold I, Fricker G, Souto E, Ferreira D, Brandl M. Brain delivery of camptothecin by means of solid lipid nanoparticles: formulation design, in vitro and in vivo studies. International Journal of Pharmaceutics. 439: 49-62. PMID 23046667 DOI: 10.1016/J.Ijpharm.2012.09.054  0.414
2012 Hüsch J, Gerbeth K, Fricker G, Setzer C, Zirkel J, Rebmann H, Schubert-Zsilavecz M, Abdel-Tawab M. Effect of phospholipid-based formulations of Boswellia serrata extract on the solubility, permeability, and absorption of the individual boswellic acid constituents present. Journal of Natural Products. 75: 1675-82. PMID 23013292 DOI: 10.1021/Np300009W  0.332
2012 Huber O, Brunner A, Maier P, Kaufmann R, Couraud PO, Cremer C, Fricker G. Localization microscopy (SPDM) reveals clustered formations of P-glycoprotein in a human blood-brain barrier model. Plos One. 7: e44776. PMID 22984556 DOI: 10.1371/Journal.Pone.0044776  0.373
2012 Frank KJ, Rosenblatt KM, Westedt U, Hölig P, Rosenberg J, Mägerlein M, Fricker G, Brandl M. Amorphous solid dispersion enhances permeation of poorly soluble ABT-102: true supersaturation vs. apparent solubility enhancement. International Journal of Pharmaceutics. 437: 288-93. PMID 22951865 DOI: 10.1016/J.Ijpharm.2012.08.014  0.323
2012 Parmentier J, Thomas N, Müllertz A, Fricker G, Rades T. Exploring the fate of liposomes in the intestine by dynamic in vitro lipolysis. International Journal of Pharmaceutics. 437: 253-63. PMID 22939968 DOI: 10.1016/J.Ijpharm.2012.08.018  0.33
2012 Frank KJ, Westedt U, Rosenblatt KM, Hölig P, Rosenberg J, Mägerlein M, Brandl M, Fricker G. Impact of FaSSIF on the solubility and dissolution-/permeation rate of a poorly water-soluble compound. European Journal of Pharmaceutical Sciences : Official Journal of the European Federation For Pharmaceutical Sciences. 47: 16-20. PMID 22579958 DOI: 10.1016/J.Ejps.2012.04.015  0.381
2012 Buckley ST, Fischer SM, Fricker G, Brandl M. In vitro models to evaluate the permeability of poorly soluble drug entities: Challenges and perspectives European Journal of Pharmaceutical Sciences. 45: 235-250. PMID 22178532 DOI: 10.1016/J.Ejps.2011.12.007  0.346
2012 Fischer SM, Buckley ST, Kirchmeyer W, Fricker G, Brandl M. Application of simulated intestinal fluid on the phospholipid vesicle-based drug permeation assay International Journal of Pharmaceutics. 422: 52-58. PMID 22027395 DOI: 10.1016/J.Ijpharm.2011.10.026  0.371
2012 Steglich B, Mahringer A, Li Y, Posner GH, Fricker G, Efferth T. Inhibition of P-glycoprotein by two artemisinin derivatives Natural Products and Bioprospecting. 2: 59-64. DOI: 10.1007/S13659-012-0006-3  0.44
2011 Mahringer A, Ott M, Reimold I, Reichel V, Fricker G. The ABC of the blood-brain barrier - regulation of drug efflux pumps. Current Pharmaceutical Design. 17: 2762-70. PMID 21827407 DOI: 10.2174/138161211797440221  0.465
2011 Fischer SM, Flaten GE, Hagesæther E, Fricker G, Brandl M. In-vitro permeability of poorly water soluble drugs in the phospholipid vesicle-based permeation assay: The influence of nonionic surfactants Journal of Pharmacy and Pharmacology. 63: 1022-1030. PMID 21718285 DOI: 10.1111/J.2042-7158.2011.01301.X  0.374
2011 Parmentier J, Thewes B, Gropp F, Fricker G. Oral peptide delivery by tetraether lipid liposomes. International Journal of Pharmaceutics. 415: 150-7. PMID 21664955 DOI: 10.1016/J.Ijpharm.2011.05.066  0.326
2011 Fischer SM, Brandl M, Fricker G. Effect of the non-ionic surfactant Poloxamer 188 on passive permeability of poorly soluble drugs across Caco-2 cell monolayers European Journal of Pharmaceutics and Biopharmaceutics. 79: 416-422. PMID 21549839 DOI: 10.1016/J.Ejpb.2011.04.010  0.403
2011 Neuwelt EA, Bauer B, Fahlke C, Fricker G, Iadecola C, Janigro D, Leybaert L, Molnár Z, O'Donnell ME, Povlishock JT, Saunders NR, Sharp F, Stanimirovic D, Watts RJ, Drewes LR. Engaging neuroscience to advance translational research in brain barrier biology. Nature Reviews. Neuroscience. 12: 169-82. PMID 21331083 DOI: 10.1038/Nrn2995  0.375
2011 Parmentier J, Becker MM, Heintz U, Fricker G. Stability of liposomes containing bio-enhancers and tetraether lipids in simulated gastro-intestinal fluids. International Journal of Pharmaceutics. 405: 210-7. PMID 21145956 DOI: 10.1016/J.Ijpharm.2010.12.005  0.309
2011 Soomro S, Langenberg T, Mahringer A, Konkimalla VB, Horwedel C, Holenya P, Brand A, Cetin C, Fricker G, Dewerchin M, Carmeliet P, Conway EM, Jansen H, Efferth T. Design of novel artemisinin-like derivatives with cytotoxic and anti-angiogenic properties. Journal of Cellular and Molecular Medicine. 15: 1122-35. PMID 20629994 DOI: 10.1111/J.1582-4934.2010.01120.X  0.305
2010 Kanzer J, Tho I, Flaten GE, Hölig P, Fricker G, Brandl M. In-vitro permeability screening of melt extrudate formulations containing poorly water-soluble drug compounds using the phospholipid vesicle-based barrier Journal of Pharmacy and Pharmacology. 62: 1591-1598. PMID 21039543 DOI: 10.1111/J.2042-7158.2010.01172.X  0.375
2010 Parmentier J, Hartmann FJ, Fricker G. In vitro evaluation of liposomes containing bio-enhancers for the oral delivery of macromolecules. European Journal of Pharmaceutics and Biopharmaceutics : Official Journal of Arbeitsgemeinschaft Fur Pharmazeutische Verfahrenstechnik E.V. 76: 394-403. PMID 20849953 DOI: 10.1016/J.Ejpb.2010.09.002  0.302
2010 Mahringer A, Fricker G. BCRP at the blood-brain barrier: genomic regulation by 17β-estradiol. Molecular Pharmaceutics. 7: 1835-47. PMID 20735085 DOI: 10.1021/Mp1001729  0.424
2010 Kläs J, Wolburg H, Terasaki T, Fricker G, Reichel V. Characterization of immortalized choroid plexus epithelial cell lines for studies of transport processes across the blood-cerebrospinal fluid barrier. Cerebrospinal Fluid Research. 7: 11. PMID 20704740 DOI: 10.1186/1743-8454-7-11  0.36
2010 Mahringer A, Karamustafa S, Klotz D, Kahl S, Konkimalla VB, Wang Y, Wang J, Liu HY, Boechzelt H, Hao X, Bauer R, Fricker G, Efferth T. Inhibition of P-glycoprotein at the blood-brain barrier by phytochemicals derived from traditional Chinese medicine. Cancer Genomics & Proteomics. 7: 191-205. PMID 20656985  0.344
2010 Reichel V, Kläs J, Fricker G, Masereeuw R. Fluo-cAMP is transported by multidrug resistance-associated protein isoform 4 in rat choroid plexus. Journal of Neurochemistry. 115: 200-8. PMID 20649844 DOI: 10.1111/J.1471-4159.2010.06915.X  0.425
2010 Fricker G, Kromp T, Wendel A, Blume A, Zirkel J, Rebmann H, Setzer C, Quinkert RO, Martin F, Müller-Goymann C. Phospholipids and lipid-based formulations in oral drug delivery. Pharmaceutical Research. 27: 1469-86. PMID 20411409 DOI: 10.1007/S11095-010-0130-X  0.354
2010 Lechner C, Reichel V, Moenning U, Reichel A, Fricker G. Development of a fluorescence-based assay for drug interactions with human Multidrug Resistance Related Protein (MRP2; ABCC2) in MDCKII-MRP2 membrane vesicles. European Journal of Pharmaceutics and Biopharmaceutics : Official Journal of Arbeitsgemeinschaft Fur Pharmazeutische Verfahrenstechnik E.V. 75: 284-90. PMID 20307659 DOI: 10.1016/J.Ejpb.2010.03.008  0.351
2010 Sauer SW, Opp S, Mahringer A, Kamiński MM, Thiel C, Okun JG, Fricker G, Morath MA, Kölker S. Glutaric aciduria type I and methylmalonic aciduria: simulation of cerebral import and export of accumulating neurotoxic dicarboxylic acids in in vitro models of the blood-brain barrier and the choroid plexus. Biochimica Et Biophysica Acta. 1802: 552-60. PMID 20302929 DOI: 10.1016/J.Bbadis.2010.03.003  0.387
2010 Ott M, Huls M, Cornelius MG, Fricker G. St. John's Wort constituents modulate P-glycoprotein transport activity at the blood-brain barrier. Pharmaceutical Research. 27: 811-22. PMID 20229133 DOI: 10.1007/S11095-010-0074-1  0.426
2009 Hülsermann U, Hoffmann MM, Massing U, Fricker G. Uptake of apolipoprotein E fragment coupled liposomes by cultured brain microvessel endothelial cells and intact brain capillaries. Journal of Drug Targeting. 17: 610-8. PMID 19694613 DOI: 10.1080/10611860903105986  0.428
2009 Mahringer A, Delzer J, Fricker G. A fluorescence-based in vitro assay for drug interactions with breast cancer resistance protein (BCRP, ABCG2). European Journal of Pharmaceutics and Biopharmaceutics : Official Journal of Arbeitsgemeinschaft Fur Pharmazeutische Verfahrenstechnik E.V. 72: 605-13. PMID 19572416 DOI: 10.1016/J.Ejpb.2009.01.010  0.322
2009 Pinto A, Hoffmans U, Ott M, Fricker G, Metzler-Nolte N. Modification with organometallic compounds improves crossing of the blood-brain barrier of [Leu5]-enkephalin derivatives in an in vitro model system Chembiochem. 10: 1852-1860. PMID 19569087 DOI: 10.1002/Cbic.200900157  0.346
2009 Kühnle M, Egger M, Müller C, Mahringer A, Bernhardt G, Fricker G, König B, Buschauer A. Potent and selective inhibitors of breast cancer resistance protein (ABCG2) derived from the p-glycoprotein (ABCB1) modulator tariquidar. Journal of Medicinal Chemistry. 52: 1190-7. PMID 19170519 DOI: 10.1021/Jm8013822  0.364
2009 Ott M, Fricker G, Bauer B. Pregnane X receptor (PXR) regulates P-glycoprotein at the blood-brain barrier: functional similarities between pig and human PXR. The Journal of Pharmacology and Experimental Therapeutics. 329: 141-9. PMID 19147857 DOI: 10.1124/Jpet.108.149690  0.485
2009 Krüger P, Kanzer J, Hummel J, Fricker G, Schubert-Zsilavecz M, Abdel-Tawab M. Permeation of Boswellia extract in the Caco-2 model and possible interactions of its constituents KBA and AKBA with OATP1B3 and MRP2. European Journal of Pharmaceutical Sciences : Official Journal of the European Federation For Pharmaceutical Sciences. 36: 275-84. PMID 19010411 DOI: 10.1016/J.Ejps.2008.10.005  0.401
2008 Fricker G. Drug interactions with natural products at the blood brain barrier. Current Drug Metabolism. 9: 1019-26. PMID 19075618 DOI: 10.2174/138920008786927758  0.42
2008 Reichel V, Miller DS, Fricker G. Texas Red transport across rat and dogfish shark (Squalus acanthias) choroid plexus. American Journal of Physiology. Regulatory, Integrative and Comparative Physiology. 295: R1311-9. PMID 18650317 DOI: 10.1152/Ajpregu.90373.2008  0.503
2008 Reimold I, Domke D, Bender J, Seyfried CA, Radunz HE, Fricker G. Delivery of nanoparticles to the brain detected by fluorescence microscopy. European Journal of Pharmaceutics and Biopharmaceutics : Official Journal of Arbeitsgemeinschaft Fã¼R Pharmazeutische Verfahrenstechnik E.V. 70: 627-32. PMID 18577452 DOI: 10.1016/J.Ejpb.2008.05.007  0.355
2008 MacLean C, Moenning U, Reichel A, Fricker G. Closing the gaps: a full scan of the intestinal expression of p-glycoprotein, breast cancer resistance protein, and multidrug resistance-associated protein 2 in male and female rats. Drug Metabolism and Disposition: the Biological Fate of Chemicals. 36: 1249-54. PMID 18378562 DOI: 10.1124/Dmd.108.020859  0.348
2008 Mitschke D, Reichel A, Fricker G, Moenning U. Characterization of cytochrome P450 protein expression along the entire length of the intestine of male and female rats. Drug Metabolism and Disposition: the Biological Fate of Chemicals. 36: 1039-45. PMID 18332081 DOI: 10.1124/Dmd.107.019687  0.315
2008 Förster F, Volz A, Fricker G. Compound profiling for ABCC2 (MRP2) using a fluorescent microplate assay system. European Journal of Pharmaceutics and Biopharmaceutics : Official Journal of Arbeitsgemeinschaft FüR Pharmazeutische Verfahrenstechnik E.V. 69: 396-403. PMID 18024096 DOI: 10.1016/J.Ejpb.2007.10.003  0.372
2007 Reichel V, Baehr C, Fricker G. From blood to brain and vice versa: transport processes in choroid plexus can be studied in vitro. Altex. 24: 53-5. PMID 19835058  0.364
2007 Adams M, Mahringer A, Kunert O, Fricker G, Efferth T, Bauer R. Cytotoxicity and p-glycoprotein modulating effects of quinolones and indoloquinazolines from the Chinese herb Evodia rutaecarpa. Planta Medica. 73: 1554-7. PMID 18058680 DOI: 10.1055/S-2007-993743  0.366
2007 Adams M, Mahringer A, Bauer R, Fricker G, Efferth T. In vitro cytotoxicity and P-glycoprotein modulating effects of geranylated furocoumarins from Tetradium daniellii. Planta Medica. 73: 1475-8. PMID 17992628 DOI: 10.1055/S-2007-990261  0.412
2007 Reichel V, Masereeuw R, van den Heuvel JJ, Miller DS, Fricker G. Transport of a fluorescent cAMP analog in teleost proximal tubules. American Journal of Physiology. Regulatory, Integrative and Comparative Physiology. 293: R2382-9. PMID 17855498 DOI: 10.1152/Ajpregu.00029.2007  0.531
2007 Bandara S, Diehl M, Fricker G. A Mathematical Model for the Transport of Paclitaxel (Taxol) Across the Blood-Brain Barrier Chemical Engineering Research and Design. 85: 1065-1071. DOI: 10.1205/Cherd06238  0.458
2006 Baehr C, Reichel V, Fricker G. Choroid plexus epithelial monolayers--a cell culture model from porcine brain. Cerebrospinal Fluid Research. 3: 13. PMID 17184532 DOI: 10.1186/1743-8454-3-13  0.403
2006 Bubik M, Ott M, Mahringer A, Fricker G. Rapid assessment of p-glycoprotein-drug interactions at the blood-brain barrier. Analytical Biochemistry. 358: 51-8. PMID 16942742 DOI: 10.1016/J.Ab.2006.07.016  0.41
2006 Baehr CH, Fricker G, Miller DS. Fluorescein-methotrexate transport in dogfish shark (Squalus acanthias) choroid plexus. American Journal of Physiology. Regulatory, Integrative and Comparative Physiology. 291: R464-72. PMID 16914433 DOI: 10.1152/Ajpregu.00814.2005  0.528
2006 Ballatori N, Henson JH, Seward DJ, Cai SY, Runnegar M, Fricker G, Miller DS, Boyer JL. Retention of structural and functional polarity in cultured skate hepatocytes undergoing in vitro morphogenesis. Comparative Biochemistry and Physiology. Part B, Biochemistry & Molecular Biology. 144: 167-79. PMID 16567119 DOI: 10.1016/J.Cbpb.2006.02.005  0.47
2006 Hartz AM, Bauer B, Fricker G, Miller DS. Rapid modulation of P-glycoprotein-mediated transport at the blood-brain barrier by tumor necrosis factor-alpha and lipopolysaccharide. Molecular Pharmacology. 69: 462-70. PMID 16278373 DOI: 10.1124/Mol.105.017954  0.753
2005 Weber CC, Kressmann S, Ott M, Fricker G, Müller WE. Inhibition of P-glycoprotein function by several antidepressants may not contribute to clinical efficacy. Pharmacopsychiatry. 38: 293-300. PMID 16342001 DOI: 10.1055/S-2005-916184  0.339
2005 Bauer B, Hartz AM, Fricker G, Miller DS. Modulation of p-glycoprotein transport function at the blood-brain barrier. Experimental Biology and Medicine (Maywood, N.J.). 230: 118-27. PMID 15673560 DOI: 10.1177/153537020523000206  0.769
2005 Rothkopf C, Fahr A, Fricker G, Scherphof GL, Kamps JA. Uptake of phosphatidylserine-containing liposomes by liver sinusoidal endothelial cells in the serum-free perfused rat liver. Biochimica Et Biophysica Acta. 1668: 10-6. PMID 15670726 DOI: 10.1016/J.Bbamem.2004.10.013  0.335
2005 Hartz A, Bauer B, Baehr C, Miller D, Fricker G. Drug Delivery Across the Blood-Brain Barrier Current Nanoscience. 1: 203-209. DOI: 10.2174/157341305774642948  0.735
2005 Flaig R, Rosenkranz V, Wink M, Fricker G. Ktenate nanoparticles (bdellosomes): a novel strategy for delivering drugs to parasites or tumours Journal of Drug Delivery Science and Technology. 15: 59-63. DOI: 10.1016/S1773-2247(05)50007-8  0.313
2004 Bauer B, Hartz AM, Fricker G, Miller DS. Pregnane X receptor up-regulation of P-glycoprotein expression and transport function at the blood-brain barrier. Molecular Pharmacology. 66: 413-9. PMID 15322232 DOI: 10.1124/Mol.66.3  0.773
2004 Hartz AM, Bauer B, Fricker G, Miller DS. Rapid regulation of P-glycoprotein at the blood-brain barrier by endothelin-1. Molecular Pharmacology. 66: 387-94. PMID 15322229 DOI: 10.1124/Mol.104.001503  0.753
2004 Breen CM, Sykes DB, Baehr C, Fricker G, Miller DS. Fluorescein-methotrexate transport in rat choroid plexus analyzed using confocal microscopy. American Journal of Physiology. Renal Physiology. 287: F562-9. PMID 15126245 DOI: 10.1152/Ajprenal.00045.2003  0.527
2004 Fricker G, Miller DS. Modulation of drug transporters at the blood-brain barrier. Pharmacology. 70: 169-76. PMID 15001817 DOI: 10.1159/000075545  0.581
2004 Elferink RP, Ottenhoff R, Fricker G, Seward DJ, Ballatori N, Boyer J. Lack of biliary lipid excretion in the little skate, Raja erinacea, indicates the absence of functional Mdr2, Abcg5, and Abcg8 transporters. American Journal of Physiology. Gastrointestinal and Liver Physiology. 286: G762-8. PMID 14701720 DOI: 10.1152/Ajpgi.00424.2003  0.344
2003 Török M, Huwyler J, Gutmann H, Fricker G, Drewe J. Modulation of transendothelial permeability and expression of ATP-binding cassette transporters in cultured brain capillary endothelial cells by astrocytic factors and cell-culture conditions. Experimental Brain Research. 153: 356-65. PMID 14610630 DOI: 10.1007/S00221-003-1620-4  0.372
2003 Erdlenbruch B, Alipour M, Fricker G, Miller DS, Kugler W, Eibl H, Lakomek M. Alkylglycerol opening of the blood-brain barrier to small and large fluorescence markers in normal and C6 glioma-bearing rats and isolated rat brain capillaries. British Journal of Pharmacology. 140: 1201-10. PMID 14597599 DOI: 10.1038/Sj.Bjp.0705554  0.524
2003 Bauer B, Miller DS, Fricker G. Compound profiling for P-glycoprotein at the blood-brain barrier using a microplate screening system. Pharmaceutical Research. 20: 1170-6. PMID 12948014 DOI: 10.1023/A:1025040712857  0.516
2002 Fellner S, Bauer B, Miller DS, Schaffrik M, Fankhänel M, Spruss T, Bernhardt G, Graeff C, Färber L, Gschaidmeier H, Buschauer A, Fricker G. Transport of paclitaxel (Taxol) across the blood-brain barrier in vitro and in vivo. The Journal of Clinical Investigation. 110: 1309-18. PMID 12417570 DOI: 10.1172/Jci15451  0.579
2002 Fricker G, Miller DS. Relevance of multidrug resistance proteins for intestinal drug absorption in vitro and in vivo. Pharmacology & Toxicology. 90: 5-13. PMID 12005113 DOI: 10.1034/J.1600-0773.2002.900103.X  0.521
2002 Huwyler J, Cerletti A, Fricker G, Eberle AN, Drewe J. By-passing of P-glycoprotein using immunoliposomes. Journal of Drug Targeting. 10: 73-9. PMID 11996089 DOI: 10.1080/10611860290007559  0.441
2002 Fricker G. Drug transport across the blood-brain barrier. Ernst Schering Research Foundation Workshop. 139-54. PMID 11975193 DOI: 10.1007/978-3-662-04383-7_7  0.357
2002 Terlouw SA, Graeff C, Smeets PH, Fricker G, Russel FG, Masereeuw R, Miller DS. Short- and long-term influences of heavy metals on anionic drug efflux from renal proximal tubule. The Journal of Pharmacology and Experimental Therapeutics. 301: 578-85. PMID 11961059 DOI: 10.1124/Jpet.301.2.578  0.514
2002 Breen CM, Sykes DB, Fricker G, Miller DS. Confocal imaging of organic anion transport in intact rat choroid plexus. American Journal of Physiology. Renal Physiology. 282: F877-85. PMID 11934698 DOI: 10.1152/Ajprenal.00171.2001  0.506
2002 Fricker G, Nobmann S, Miller DS. Permeability of porcine blood brain barrier to somatostatin analogues. British Journal of Pharmacology. 135: 1308-14. PMID 11877340 DOI: 10.1038/Sj.Bjp.0704557  0.578
2002 Miller DS, Graeff C, Droulle L, Fricker S, Fricker G. Xenobiotic efflux pumps in isolated fish brain capillaries. American Journal of Physiology. Regulatory, Integrative and Comparative Physiology. 282: R191-8. PMID 11742838 DOI: 10.1152/Ajpregu.00305.2001  0.604
2002 Thöle M, Nobmann S, Huwyler J, Bartmann A, Fricker G. Uptake of Cationized Albumin Coupled Liposomes by Cultured Porcine Brain Microvessel Endothelial Cells and Intact Brain Capillaries Journal of Drug Targeting. 10: 337-344. DOI: 10.1080/10611860290031840  0.409
2001 Drewe J, Beglinger C, Fricker G. Effect of ischemia on intestinal permeability of lipopolysaccharides. European Journal of Clinical Investigation. 31: 138-44. PMID 11168452 DOI: 10.1046/J.1365-2362.2001.00792.X  0.331
2001 Nobmann S, Bauer B, Fricker G. Ivermectin excretion by isolated functionally intact brain endothelial capillaries. British Journal of Pharmacology. 132: 722-8. PMID 11159725 DOI: 10.1038/Sj.Bjp.0703762  0.481
2000 Miller DS, Nobmann SN, Gutmann H, Toeroek M, Drewe J, Fricker G. Xenobiotic transport across isolated brain microvessels studied by confocal microscopy. Molecular Pharmacology. 58: 1357-67. PMID 11093774 DOI: 10.1124/Mol.58.6.1357  0.602
2000 Gutmann H, Miller DS, Droulle A, Drewe J, Fahr A, Fricker G. P-glycoprotein- and mrp2-mediated octreotide transport in renal proximal tubule. British Journal of Pharmacology. 129: 251-6. PMID 10694230 DOI: 10.1038/Sj.Bjp.0703003  0.532
2000 Cerletti A, Drewe J, Fricker G, Eberle A, Huwyler J. Endocytosis and Transcytosis of an Immunoliposome-Based Brain Drug Delivery System Journal of Drug Targeting. 8: 435-446. DOI: 10.3109/10611860008997919  0.42
1999 Drewe J, Gutmann H, Fricker G, Török M, Beglinger C, Huwyler J. HIV protease inhibitor ritonavir: a more potent inhibitor of P-glycoprotein than the cyclosporine analog SDZ PSC 833. Biochemical Pharmacology. 57: 1147-52. PMID 11230802 DOI: 10.1016/S0006-2952(99)00026-X  0.376
1999 Fricker G, Gutmann H, Droulle A, Drewe J, Miller DS. Epithelial transport of anthelmintic ivermectin in a novel model of isolated proximal kidney tubules. Pharmaceutical Research. 16: 1570-5. PMID 10554099 DOI: 10.1023/A:1018956621376  0.491
1999 Gutmann H, Fricker G, Drewe J, Toeroek M, Miller DS. Interactions of HIV protease inhibitors with ATP-dependent drug export proteins. Molecular Pharmacology. 56: 383-9. PMID 10419558 DOI: 10.1124/Mol.56.2.383  0.531
1999 Gutmann H, Fricker G, Török M, Michael S, Beglinger C, Drewe J. Evidence for different ABC-transporters in Caco-2 cells modulating drug uptake. Pharmaceutical Research. 16: 402-7. PMID 10213371 DOI: 10.1023/A:1018825819249  0.403
1999 Török M, Gutmann H, Fricker G, Drewe J. Sister of P-glycoprotein expression in different tissues. Biochemical Pharmacology. 57: 833-5. PMID 10075089 DOI: 10.1016/S0006-2952(98)00357-8  0.423
1997 Fricker G, Wössner R, Drewe J, Fricker R, Boyer JL. Enterohepatic circulation of scymnol sulfate in an elasmobranch, the little skate (Raja erinacea). The American Journal of Physiology. 273: G1023-30. PMID 9374698 DOI: 10.1152/Ajpgi.1997.273.5.G1023  0.307
1997 Fricker G, Küsters E. Intestinal absorption of sugar-coupled somatostatin analogs. Journal of Pharmaceutical Sciences. 85: 1211-4. PMID 8923327 DOI: 10.1021/Js960052F  0.337
1997 Urwyler S, Campbell E, Fricker G, Jenner P, Lemaire M, McAllister KH, Neijt HC, Park CK, Perkins M, Rudin M, Sauter A, Smith L, Wiederhold KH, Müller W. Biphenyl-derivatives of 2-amino-7-phosphono-heptanoic acid, a novel class of potent competitive N-methyl-D-aspartate receptor antagonists--II. Pharmacological characterization in vivo. Neuropharmacology. 35: 655-69. PMID 8887975 DOI: 10.1016/0028-3908(96)84637-5  0.315
1997 Huwyler J, Drewe J, Klusemann C, Fricker G. Evidence for P-glycoprotein-modulated penetration of morphine-6-glucuronide into brain capillary endothelium. British Journal of Pharmacology. 118: 1879-85. PMID 8864518 DOI: 10.1111/J.1476-5381.1996.Tb15619.X  0.419
1996 Fricker G, Drewe J, Huwyler J, Gutmann H, Beglinger C. Relevance of p-glycoprotein for the enteral absorption of cyclosporin A: in vitro-in vivo correlation. British Journal of Pharmacology. 118: 1841-7. PMID 8842452 DOI: 10.1111/J.1476-5381.1996.Tb15612.X  0.421
1996 Fricker G, Fahr A, Beglinger C, Kissel T, Reiter G, Drewe J. Permeation enhancement of octreotide by specific bile salts in rats and human subjects: in vitro, in vivo correlations. British Journal of Pharmacology. 117: 217-23. PMID 8825366 DOI: 10.1111/J.1476-5381.1996.Tb15177.X  0.345
1996 Miller DS, Fricker G, Schramm U, Henson JH, Hager DN, Nundy S, Ballatori N, Boyer JL. Active microtubule-dependent secretion of a fluorescent bile salt derivative in skate hepatocyte clusters. The American Journal of Physiology. 270: G887-96. PMID 8764193 DOI: 10.1152/Ajpgi.1996.270.6.G887  0.493
1996 de Fraissinette A, Kolopp M, Schiller I, Fricker G, Gammert C, Pospischil A, Vonderscher J, Richter F. In vitro tolerability of human nasal mucosa: histopathological and scanning electron-microscopic evaluation of nasal forms containing Sandostatin. Cell Biology and Toxicology. 11: 295-301. PMID 8608410 DOI: 10.1007/Bf00757627  0.314
1996 Oechslein CR, Fricker G, Kissel T. Nasal delivery of octreotide: Absorption enhancement by particulate carrier systems International Journal of Pharmaceutics. 139: 25-32. DOI: 10.1016/0378-5173(96)04569-3  0.308
1995 Schramm U, Fricker G, Wenger R, Miller DS. P-glycoprotein-mediated secretion of a fluorescent cyclosporin analogue by teleost renal proximal tubules. The American Journal of Physiology. 268: F46-52. PMID 7840247 DOI: 10.1152/Ajprenal.1995.268.1.F46  0.491
1995 Fahr A, Holz M, Fricker G. Liposomal Formulations of Cyclosporin A: Influence of Lipid Type and Dose on Pharmacokinetics Pharmaceutical Research: An Official Journal of the American Association of Pharmaceutical Scientists. 12: 1189-1198. PMID 7494833 DOI: 10.1023/A:1016220211925  0.323
1994 Jaehde U, Masereeuw R, De Boer AG, Fricker G, Nagelkerke JF, Vonderscher J, Breimer DD. Quantification and visualization of the transport of octreotide, a somatostatin analogue, across monolayers of cerebrovascular endothelial cells. Pharmaceutical Research. 11: 442-8. PMID 8008714 DOI: 10.1023/A:1018929508018  0.425
1994 Fricker G, Dubost V, Finsterwald K, Boyer JL. Characteristics of bile salt uptake into skate hepatocytes Biochemical Journal. 299: 665-670. DOI: 10.1042/Bj2990665  0.316
1993 Drewe J, Fricker G, Vonderscher J, Beglinger C. Enteral absorption of octreotide: absorption enhancement by polyoxyethylene-24-cholesterol ether. British Journal of Pharmacology. 108: 298-303. PMID 8448581 DOI: 10.1111/J.1476-5381.1993.Tb12799.X  0.36
1991 Fricker G, Bruns C, Munzer J, Briner U, Albert R, Kissel T, Vonderscher J. Intestinal absorption of the octapeptide SMS 201-995 visualized by fluorescence derivatization. Gastroenterology. 100: 1544-52. PMID 2019360 DOI: 10.1016/0016-5085(91)90651-Z  0.334
1989 Fricker G, Landmann L, Meier PJ. Extrahepatic obstructive cholestasis reverses the bile salt secretory polarity of rat hepatocytes Journal of Clinical Investigation. 84: 876-885. PMID 2760217 DOI: 10.1172/Jci114248  0.342
1988 Fricker G, Schneider S, Gerok W, Kurz G. Identification of different transport systems for bile salts in sinusoidal and canalicular membranes of hepatocytes. Biological Chemistry Hoppe-Seyler. 368: 1143-50. PMID 3675867 DOI: 10.1515/Bchm3.1987.368.2.1143  0.335
1987 Hugentobler G, Fricker G, Boyer JL, Meier PJ. Anion transport in basolateral (sinusoidal) liver plasma-membrane vesicles of the little skate (Raja erinacea) Biochemical Journal. 247: 589-595. PMID 3426551 DOI: 10.1042/Bj2470589  0.318
1987 Fricker G, Hugentobler G, Meier PJ, Kurz G, Boyer JL. Identification of a single sinusoidal bile salt uptake system in skate liver American Journal of Physiology - Gastrointestinal and Liver Physiology. 253. PMID 3425718 DOI: 10.1152/Ajpgi.1987.253.6.G816  0.348
Show low-probability matches.