Year |
Citation |
Score |
2020 |
Knutson DE, Smith JL, Ping X, Jin X, Golani LK, Li G, Tiruveedhula VVNPB, Rashid F, Mian MY, Jahan R, Sharmin D, Cerne R, Cook JM, Witkin JM. The Imidazodiazepine Anticonvulsant, KRM-II-81, Produces Novel, Non-diazepam-like Antiseizure Effects. Acs Chemical Neuroscience. PMID 32786313 DOI: 10.1021/Acschemneuro.0C00295 |
0.757 |
|
2019 |
Witkin JM, Li G, Golani LK, Xiong W, Smith JL, Ping X, Rashid F, Jahan R, Cerne R, Cook JM, Jin X. The positive allosteric modulator of α2/3-containing GABAA receptors, KRM-II-81, is active in pharmaco-resistant models of epilepsy and reduces hyperexcitability after traumatic brain injury. The Journal of Pharmacology and Experimental Therapeutics. PMID 31694876 DOI: 10.1124/Jpet.119.260968 |
0.73 |
|
2019 |
Forkuo GS, Nieman AN, Kodali R, Zahn NM, Li G, Roni MSR, Stephen MR, Harris TW, Jahan R, Guthrie ML, Yu OB, Fisher JL, Yocum GT, Emala CW, Steeber DA, et al. Correction to "A Novel Orally Available Asthma Drug Candidate That Reduces Smooth Muscle Constriction and Inflammation by Targeting GABA Receptors in the Lung". Molecular Pharmaceutics. PMID 31633359 DOI: 10.1021/acs.molpharmaceut.9b01053 |
0.727 |
|
2019 |
Witkin JM, Ping X, Cerne R, Mouser C, Jin X, Hobbs J, Tiruveedhula VVNPB, Li G, Jahan R, Rashid F, Kumar Golani L, Cook JM, Smith JL. The value of human epileptic tissue in the characterization and development of novel antiepileptic drugs:The example of CERC-611 and KRM-II-81. Brain Research. 146356. PMID 31369732 DOI: 10.1016/J.Brainres.2019.146356 |
0.725 |
|
2019 |
Berro LF, Rüedi-Bettschen D, Cook JE, Golani LK, Li G, Jahan R, Rashid F, Cook JM, Rowlett JK, Platt DM. GABA receptor subtypes and the abuse-related effects of ethanol in rhesus monkeys: Experiments with selective positive allosteric modulators. Alcoholism, Clinical and Experimental Research. PMID 30861153 DOI: 10.1111/Acer.14000 |
0.688 |
|
2019 |
Witkin JM, Cerne R, Davis PG, Freeman KB, do Carmo JM, Rowlett JK, Methuku KR, Okun A, Gleason SD, Li X, Krambis MJ, Poe M, Li G, Schkeryantz JM, Jahan R, et al. The α2,3-selective potentiator of GABA receptors, KRM-II-81, reduces nociceptive-associated behaviors induced by formalin and spinal nerve ligation in rats. Pharmacology, Biochemistry, and Behavior. PMID 30825491 DOI: 10.1016/J.Pbb.2019.02.013 |
0.766 |
|
2019 |
Smith JL, Ping X, Jin X, Golani LK, Li G, Rashid F, Jahan R, Cook JM, Witkin JM. The Positive Allosteric Modulator of Alpha-2/3-Containing γ-Aminobutyric Acid Type A Receptors, KRM-II-81, Is Active in Pharmacoresistant Models of Epilepsy and in Human Epileptic Tissue Neurosurgery. 66. DOI: 10.1093/Neuros/Nyz310_697 |
0.737 |
|
2018 |
Li G, Golani LK, Jahan R, Rashid F, Cook JM. Improved Synthesis of Anxiolytic, Anticonvulsant and Antinociceptive α2/α3-GABA(A)ergic Receptor Subtype Selective Ligands as Promising Agents to Treat Anxiety, Epilepsy, as well as Neuropathic Pain. Synthesis. 50: 4124-4132. PMID 32773890 DOI: 10.1055/S-0037-1610211 |
0.727 |
|
2018 |
Forkuo GS, Nieman AN, Kodali R, Zahn NM, Li G, Rashid Roni S, Stephen MR, Harris TW, Jahan R, Guthrie ML, Yu OB, Fisher JL, Yocum GT, Emala CW, Steeber DA, et al. A novel orally available asthma drug candidate that reduces smooth muscle constriction and inflammation by targeting GABA(A) receptors in the lung. Molecular Pharmaceutics. PMID 29578347 DOI: 10.1021/Acs.Molpharmaceut.7B01013 |
0.751 |
|
2017 |
Forkuo GS, Nieman AN, Yuan NY, Kodali R, Yu OB, Zahn NM, Jahan R, Li G, Stephen MR, Guthrie ML, Poe MM, Hartzler BD, Harris TW, Yocum GT, Emala CW, et al. Alleviation of Multiple Asthmatic Pathologic Features with Orally Available and Subtype Selective GABAA Receptor Modulators. Molecular Pharmaceutics. PMID 28440659 DOI: 10.1021/Acs.Molpharmaceut.7B00183 |
0.761 |
|
2017 |
Arnold L, Forkuo G, Nieman A, Yu OB, Guthrie ML, Kodali R, Yuan N, Jahan R, Stephen MS, Emala CW, Yocum GT, Cook JM, Grayson MH. New Oral Treatments for Asthma through Tissue-Specific Modulation of the GABAA Receptor Journal of Allergy and Clinical Immunology. 139: AB9. DOI: 10.1016/J.Jaci.2016.12.083 |
0.557 |
|
2016 |
Jahan R, Stephen MR, Forkuo GS, Kodali R, Guthrie ML, Nieman AN, Yuan NY, Zahn NM, Poe MM, Li G, Yu OB, Yocum GT, Emala CW, Stafford DC, Cook JM, et al. Optimization of substituted imidazobenzodiazepines as novel asthma treatments. European Journal of Medicinal Chemistry. 126: 550-560. PMID 27915170 DOI: 10.1016/J.Ejmech.2016.11.045 |
0.748 |
|
2016 |
Forkuo GS, Guthrie ML, Yuan NY, Nieman AN, Kodali R, Jahan R, Yocum GT, Treven M, Stephen MR, Poe MM, Li G, Yu OB, Hartzler BD, Zahn NM, Ernst M, et al. Development of GABAA Receptor Subtype-Selective Imidazobenzodiazepines as Novel Asthma treatments. Molecular Pharmaceutics. PMID 27120014 DOI: 10.1021/Acs.Molpharmaceut.6B00159 |
0.777 |
|
2016 |
Arnold LA, Forkuo GS, Nieman AN, Yu OB, Guthrie ML, Yuan NY, Kodali R, Jahan R, Emala CW, Cook JM, Stafford DC, Grayson MH. A New Pharmacological Approach for Asthma through Tissue-Specific Modulation of the GABA(A) Receptor Journal of Allergy and Clinical Immunology. 137: AB393. DOI: 10.1016/J.Jaci.2015.12.1218 |
0.587 |
|
2015 |
Yocum GT, Gallos G, Zhang Y, Jahan R, Stephen MR, Varagic Z, Puthenkalam R, Ernst M, Cook JM, Emala CW. Targeting the GABAA Receptor α4 Subunit in Airway Smooth Muscle to Alleviate Bronchoconstriction. American Journal of Respiratory Cell and Molecular Biology. PMID 26405827 DOI: 10.1165/Rcmb.2015-0176Oc |
0.574 |
|
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