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Guanguan Li - Publications

Affiliations: 
2012-2019 Chemistry and Biochemistry University of Wisconsin-Milwaukee, Milwaukee, WI 
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52 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2022 Souza AJ, Cortez IL, Silva NR, Pedrazzi JFC, Domingos LB, Braga MS, Santos-Silva T, Del-Bel EA, Resstel LBM, Li G, Mian MY, Sharmin D, Guimarães FS, Cook JM, Gomes FV. Distinct sex-dependent behavioral responses induced by two positive allosteric modulators of alpha 5 subunit-containing GABA receptors. Behavioural Brain Research. 113832. PMID 35259414 DOI: 10.1016/j.bbr.2022.113832  0.466
2021 Chandler CM, Reeves-Darby J, Jones SA, Li G, Rahman MT, Cook JM, Platt DM. Modulation of relapse-like drinking in male Sprague-Dawley rats by ligands targeting the α5GABA receptor. Neuropharmacology. 108785. PMID 34509495 DOI: 10.1016/j.neuropharm.2021.108785  0.472
2021 Fee C, Prevot TD, Misquitta K, Knutson DE, Li G, Mondal P, Cook JM, Banasr M, Sibille E. Behavioral deficits induced by somatostatin-positive GABA neuron silencing are rescued by alpha 5 GABA-A receptor potentiation. The International Journal of Neuropsychopharmacology. PMID 33438026 DOI: 10.1093/ijnp/pyab002  0.771
2020 Pomeranz Krummel DA, Nasti TH, Kaluzova M, Kallay L, Bhattacharya D, Melms JC, Izar B, Xu M, Burnham A, Ahmed T, Li G, Lawson D, Kowalski J, Cao Y, Switchenko JM, et al. Melanoma Cell Intrinsic GABA Receptor Enhancement Potentiates Radiation and Immune Checkpoint Inhibitor Response by Promoting Direct and T Cell-Mediated Antitumor Activity. International Journal of Radiation Oncology, Biology, Physics. PMID 33289666 DOI: 10.1016/j.ijrobp.2020.10.025  0.363
2020 Prevot TD, Sumitomo A, Tomoda T, Knutson DE, Li G, Mondal P, Banasr M, Cook JM, Sibille E. Reversal of Age-Related Neuronal Atrophy by α5-GABAA Receptor Positive Allosteric Modulation. Cerebral Cortex (New York, N.Y. : 1991). PMID 33068001 DOI: 10.1093/cercor/bhaa310  0.748
2020 Li G, Nieman AN, Mian MY, Zahn NM, Mikulsky BN, Poe MM, Methuku KR, Liu Y, Cook JM, Stafford DC, Arnold LA. A Structure-Activity Relationship Comparison of Imidazodiazepines Binding at Kappa, Mu, and Delta Opioid Receptors and the GABA Receptor. Molecules (Basel, Switzerland). 25. PMID 32854311 DOI: 10.3390/Molecules25173864  0.73
2020 Knutson DE, Smith JL, Ping X, Jin X, Golani LK, Li G, Tiruveedhula VVNPB, Rashid F, Mian MY, Jahan R, Sharmin D, Cerne R, Cook JM, Witkin JM. The Imidazodiazepine Anticonvulsant, KRM-II-81, Produces Novel, Non-diazepam-like Antiseizure Effects. Acs Chemical Neuroscience. PMID 32786313 DOI: 10.1021/Acschemneuro.0C00295  0.8
2020 Nieman AN, Li G, Zahn NM, Mian MY, Mikulsky BN, Hoffman DA, Wilcox TM, Kehoe AS, Luecke IW, Poe MM, Alvarez-Carbonell D, Cook JM, Stafford DC, Arnold LA. Targeting nitric oxide production in microglia with novel imidazodiazepines for non-sedative pain treatment. Acs Chemical Neuroscience. PMID 32511908 DOI: 10.1021/Acschemneuro.0C00324  0.748
2020 Roni MSR, Li G, Mikulsky BN, Knutson DE, Mian MY, Zahn NM, Cook JM, Stafford DC, Arnold LA. The effects of pH on the structure and bioavailability of imidazobenzodiazepine-3-carboxylate MIDD0301. Molecular Pharmaceutics. PMID 32069056 DOI: 10.1021/Acs.Molpharmaceut.9B01210  0.709
2020 Prevot T, Li G, Knutson D, Mondal P, Mian Y, Guilloux J, Mendez-David I, David D, Cook J, Sibille E. Improved Cognitive Functions and Neurotrophic Effects of a Novel Molecule Enhancing α5-GABA-A Receptor Function in Adult or Aged Mice Biological Psychiatry. 87: S404. DOI: 10.1016/J.Biopsych.2020.02.1032  0.769
2019 McCusker P, Mian MY, Li G, Olp MD, Tiruveedhula VVNPB, Rashid F, Golani LK, Verma RS, Smith BC, Cook JM, Chan JD. Non-sedating benzodiazepines cause paralysis and tissue damage in the parasitic blood fluke Schistosoma mansoni. Plos Neglected Tropical Diseases. 13: e0007826. PMID 31730614 DOI: 10.1371/Journal.Pntd.0007826  0.481
2019 Witkin JM, Li G, Golani LK, Xiong W, Smith JL, Ping X, Rashid F, Jahan R, Cerne R, Cook JM, Jin X. The positive allosteric modulator of α2/3-containing GABAA receptors, KRM-II-81, is active in pharmaco-resistant models of epilepsy and reduces hyperexcitability after traumatic brain injury. The Journal of Pharmacology and Experimental Therapeutics. PMID 31694876 DOI: 10.1124/Jpet.119.260968  0.678
2019 Meng Z, Berro LF, Sawyer EK, Rüedi-Bettschen D, Cook JE, Li G, Platt DM, Cook JM, Rowlett JK. Evaluation of the anti-conflict, reinforcing, and sedative effects of YT-III-31, a ligand functionally selective for α3 subunit-containing GABA receptors. Journal of Psychopharmacology (Oxford, England). 269881119882803. PMID 31670615 DOI: 10.1177/0269881119882803  0.623
2019 Forkuo GS, Nieman AN, Kodali R, Zahn NM, Li G, Roni MSR, Stephen MR, Harris TW, Jahan R, Guthrie ML, Yu OB, Fisher JL, Yocum GT, Emala CW, Steeber DA, et al. Correction to "A Novel Orally Available Asthma Drug Candidate That Reduces Smooth Muscle Constriction and Inflammation by Targeting GABA Receptors in the Lung". Molecular Pharmaceutics. PMID 31633359 DOI: 10.1021/acs.molpharmaceut.9b01053  0.682
2019 Witkin JM, Ping X, Cerne R, Mouser C, Jin X, Hobbs J, Tiruveedhula VVNPB, Li G, Jahan R, Rashid F, Kumar Golani L, Cook JM, Smith JL. The value of human epileptic tissue in the characterization and development of novel antiepileptic drugs:The example of CERC-611 and KRM-II-81. Brain Research. 146356. PMID 31369732 DOI: 10.1016/J.Brainres.2019.146356  0.702
2019 Prevot TD, Li G, Vidojevic A, Misquitta KA, Fee C, Santrac A, Knutson DE, Stephen MR, Kodali R, Zahn NM, Arnold LA, Scholze P, Fisher JL, Marković BD, Banasr M, et al. Novel Benzodiazepine-Like Ligands with Various Anxiolytic, Antidepressant, or Pro-Cognitive Profiles. Molecular Neuropsychiatry. 5: 84-97. PMID 31192221 DOI: 10.1159/000496086  0.775
2019 Prevot TD, Li G, Cook JM, Sibille E. Insight into Novel Treatment for Cognitive Dysfunctions across Disorders. Acs Chemical Neuroscience. PMID 30920790 DOI: 10.1021/Acschemneuro.9B00148  0.545
2019 Berro LF, Rüedi-Bettschen D, Cook JE, Golani LK, Li G, Jahan R, Rashid F, Cook JM, Rowlett JK, Platt DM. GABA receptor subtypes and the abuse-related effects of ethanol in rhesus monkeys: Experiments with selective positive allosteric modulators. Alcoholism, Clinical and Experimental Research. PMID 30861153 DOI: 10.1111/Acer.14000  0.701
2019 Witkin JM, Cerne R, Davis PG, Freeman KB, do Carmo JM, Rowlett JK, Methuku KR, Okun A, Gleason SD, Li X, Krambis MJ, Poe M, Li G, Schkeryantz JM, Jahan R, et al. The α2,3-selective potentiator of GABA receptors, KRM-II-81, reduces nociceptive-associated behaviors induced by formalin and spinal nerve ligation in rats. Pharmacology, Biochemistry, and Behavior. PMID 30825491 DOI: 10.1016/J.Pbb.2019.02.013  0.821
2019 Kallay L, Keskin H, Ross A, Rupji M, Moody OA, Wang X, Li G, Ahmed T, Rashid F, Stephen MR, Cottrill KA, Nuckols TA, Xu M, Martinson DE, Tranghese F, et al. Modulating native GABA receptors in medulloblastoma with positive allosteric benzodiazepine-derivatives induces cell death. Journal of Neuro-Oncology. PMID 30725256 DOI: 10.1007/S11060-019-03115-0  0.547
2019 Zahn NM, Huber AT, Mikulsky BN, Stepanski ME, Kehoe AS, Li G, Schussman M, Rashid Roni MS, Kodali R, Cook JM, Stafford DC, Steeber DA, Arnold LA. MIDD0301 - A first-in-class anti-inflammatory asthma drug targets GABA receptors without causing systemic immune suppression. Basic & Clinical Pharmacology & Toxicology. PMID 30694594 DOI: 10.1111/Bcpt.13206  0.507
2019 Moerke MJ, Li G, Golani LK, Cook J, Negus SS. Effects of the α2/α3-subtype-selective GABAA receptor positive allosteric modulator KRM-II-81 on pain-depressed behavior in rats: comparison with ketorolac and diazepam. Behavioural Pharmacology. PMID 30640180 DOI: 10.1097/Fbp.0000000000000464  0.538
2019 Chandler CM, Reeves-Darby J, Jones SA, McDonald JA, Li G, Rahman MT, Cook JM, Platt DM. α5GABA subunit-containing receptors and sweetened alcohol cue-induced reinstatement and active sweetened alcohol self-administration in male rats. Psychopharmacology. PMID 30637435 DOI: 10.1007/S00213-018-5163-6  0.495
2019 Kallay L, Keskin H, Ross A, Rupji M, Moody OA, Wang X, Li G, Ahmed T, Rashid F, Stephen MR, Cottrill KA, Nuckois A, Xu M, Martinson DE, Tranghese F, et al. Abstract 2623: Modulating native GABAA receptors in medulloblastoma with positive allosteric benzodiazepine-derivatives induces cell death Cancer Research. 79: 2623-2623. DOI: 10.1158/1538-7445.Am2019-2623  0.53
2019 Smith JL, Ping X, Jin X, Golani LK, Li G, Rashid F, Jahan R, Cook JM, Witkin JM. The Positive Allosteric Modulator of Alpha-2/3-Containing γ-Aminobutyric Acid Type A Receptors, KRM-II-81, Is Active in Pharmacoresistant Models of Epilepsy and in Human Epileptic Tissue Neurosurgery. 66. DOI: 10.1093/Neuros/Nyz310_697  0.708
2019 Pomeranz Krummel D, Nasti T, Izar B, Xu M, Lowder L, Press R, Kaluzova M, Kallay L, Rupji M, Burnham A, Li G, Ahmed T, Rosen H, Connolly E, Keskin H, et al. EXTH-12. RADIATION ENHANCES MELANOMA RESPONSE TO IMMUNOTHERAPY AND SYNERGIZES WITH BENZODIAZEPINES TO PROMOTE ANTI-TUMOR ACTIVITY Neuro-Oncology. 21: vi84-vi84. DOI: 10.1093/Neuonc/Noz175.346  0.453
2019 Prevot T, Li G, Misquitta K, Fee C, Knutson D, Stephen MR, Kodali R, Zahn N, Arnold LA, Banasr M, Cook J, Sibille E. T117. Pro-Cognitive Properties of a Novel GABA-A Receptor Positive Modulator in Animal Models of Depression and Aging Biological Psychiatry. 85: S174. DOI: 10.1016/J.Biopsych.2019.03.440  0.765
2018 Li G, Stephen MR, Kodali R, Zahn NM, Poe MM, Tiruveedhula VVNPB, Huber AT, Schussman MK, Qualmann K, Panhans CM, Raddatz NJ, Baker DA, Prevot TD, Banasr M, Sibille E, et al. Synthesis of chiral GABA receptor subtype selective ligands as potential agents to treat schizophrenia as well as depression. Arkivoc : Free Online Journal of Organic Chemistry. 2018: 158-182. PMID 32774192 DOI: 10.24820/Ark.5550190.P010.460  0.744
2018 Li G, Golani LK, Jahan R, Rashid F, Cook JM. Improved Synthesis of Anxiolytic, Anticonvulsant and Antinociceptive α2/α3-GABA(A)ergic Receptor Subtype Selective Ligands as Promising Agents to Treat Anxiety, Epilepsy, as well as Neuropathic Pain. Synthesis. 50: 4124-4132. PMID 32773890 DOI: 10.1055/S-0037-1610211  0.716
2018 Neumann E, Rudolph U, Knutson DE, Li G, Cook JM, Hentschke H, Antkowiak B, Drexler B. Zolpidem Activation of Alpha 1-Containing GABA Receptors Selectively Inhibits High Frequency Action Potential Firing of Cortical Neurons. Frontiers in Pharmacology. 9: 1523. PMID 30687091 DOI: 10.3389/Fphar.2018.01523  0.786
2018 Yocum GT, Perez-Zoghbi JF, Danielsson J, Kuforiji AS, Zhang Y, Li G, Roni MSR, Kodali R, Stafford DC, Arnold LA, Cook JM, Emala CW. A Novel GABA Receptor Ligand MIDD0301 with Limited Blood-Brain Barrier Penetration Relaxes Airway Smooth Muscle Ex Vivo and In Vivo. American Journal of Physiology. Lung Cellular and Molecular Physiology. PMID 30489155 DOI: 10.1152/Ajplung.00356.2018  0.575
2018 Batinić B, Stanković T, Stephen MR, Kodali R, Tiruveedhula VV, Li G, Scholze P, Marković BD, Obradović AL, Ernst M, Cook JM, Savić MM. Attaining in vivo selectivity of positive modulation of α3βγ2 GABA receptors in rats: A hard task! European Neuropsychopharmacology : the Journal of the European College of Neuropsychopharmacology. PMID 29891214 DOI: 10.1016/J.Euroneuro.2018.05.014  0.6
2018 Witkin JM, Smith JL, Ping X, Gleason SD, Poe MM, Li G, Jin X, Hobbs J, Schkeryantz JM, McDermott JS, Alatorre AI, Siemian JN, Cramer JW, Airey DC, Methuku KR, et al. Bioisosteres of ethyl 8-ethynyl-6-(pyridin-2-yl)-4H-benzo[f]imidazo [1,5-a][1,4]diazepine-3-carboxylate (HZ-166) as novel alpha 2,3 selective potentiators of GABA receptors: Improved bioavailability enhances anticonvulsant efficacy. Neuropharmacology. 137: 332-343. PMID 29778948 DOI: 10.1016/J.Neuropharm.2018.05.006  0.783
2018 Elgarf AA, Siebert DCB, Steudle F, Draxler A, Li G, Huang S, Cook JM, Ernst M, Scholze P. Different Benzodiazepines Bind with Distinct Binding Modes to GABA Receptors. Acs Chemical Biology. PMID 29767950 DOI: 10.1021/Acschembio.8B00144  0.763
2018 Duke AN, Meng Z, Platt DM, Atack JR, Dawson GR, Reynolds DS, Tiruveedhula VVNPB, Li G, Stephen MR, Sieghart W, Cook JM, Rowlett JK. Evidence that Sedative Effects of Benzodiazepines Involve Unexpected GABA Receptor Subtypes: Quantitative Observation Studies in Rhesus Monkeys. The Journal of Pharmacology and Experimental Therapeutics. PMID 29720564 DOI: 10.1124/Jpet.118.249250  0.595
2018 Methuku KR, Li X, Cerne R, Gleason SD, Schkeryantz JM, Tiruveedhula VVNPB, Golani LK, Li G, Poe MM, Rahman MT, Cook JM, Fisher JL, Witkin JM. An antidepressant-related pharmacological signature for positive allosteric modulators of α2/3-containing GABA receptors. Pharmacology, Biochemistry, and Behavior. PMID 29715490 DOI: 10.1016/J.Pbb.2018.04.009  0.773
2018 Forkuo GS, Nieman AN, Kodali R, Zahn NM, Li G, Rashid Roni S, Stephen MR, Harris TW, Jahan R, Guthrie ML, Yu OB, Fisher JL, Yocum GT, Emala CW, Steeber DA, et al. A novel orally available asthma drug candidate that reduces smooth muscle constriction and inflammation by targeting GABA(A) receptors in the lung. Molecular Pharmaceutics. PMID 29578347 DOI: 10.1021/Acs.Molpharmaceut.7B01013  0.723
2018 Xu NZ, Ernst M, Treven M, Cerne R, Wakulchik M, Li X, Jones TM, Gleason SD, Morrow D, Schkeryantz JM, Rahman MT, Li G, Poe MM, Cook JM, Witkin JM. Negative allosteric modulation of alpha 5-containing GABAA receptors engenders antidepressant-like effects and selectively prevents age-associated hyperactivity in tau-depositing mice. Psychopharmacology. PMID 29374303 DOI: 10.1007/S00213-018-4832-9  0.785
2018 Li G, Stephen MR, Kodali R, Zahn NM, Poe MM, Tiruveedhula VVNPB, Huber AT, Schussman MK, Qualmann K, Panhans CM, Raddatz NJ, Baker DA, Prevot TD, Banasr M, Sibille E, et al. Synthesis of chiral GABAA receptor subtype selective ligands as potential agents to treat schizophrenia as well as depression Arkivoc. 2018: 158-182. DOI: 10.24820/ark.5550190.p010.460  0.688
2018 Kallay L, Keskin H, Ross A, Moody O, Cottrill K, Nuckols A, Li G, Ahmed T, Rashid F, Stephen M, Xu M, Martinson D, Macdonald T, Kowalski J, Wang X, et al. PDTM-45. POSITIVE MODULATION OF NATIVE GABAA RECEPTORS IN MEDULLOBLASTOMA CANCER CELLS WITH BENZODIAZEPINES INDUCES RAPID MITOCHONDRIAL FRAGMENTATION AND TP53-DEPENDENT, CELL CYCLE-INDEPENDENT APOPTOSIS Neuro-Oncology. 20: vi213-vi213. DOI: 10.1093/Neuonc/Noy148.884  0.467
2018 Prevot T, Li G, Vidojevic A, Santrac A, Misquitta K, Hu X, Knutson D, Arnold L, Fisher J, Banasr M, Cook J, Savic M, Sibille E. S162. Antidepressant and Pro-Cognitive Effects of a Novel Series of GABA-A Receptor Positive Allosteric Modulators With α5 Subunit Efficacy Properties Biological Psychiatry. 83: S411. DOI: 10.1016/J.Biopsych.2018.02.1054  0.791
2017 Meyer MAA, Corcoran KA, Chen HJ, Gallego S, Li G, Tiruveedhula VV, Cook JM, Radulovic J. Neurobiological correlates of state-dependent context fear. Learning & Memory (Cold Spring Harbor, N.Y.). 24: 385-391. PMID 28814463 DOI: 10.1101/Lm.045542.117  0.471
2017 Batinić B, Santrač A, Jančić I, Li G, Vidojević A, Marković B, Cook JM, Savić MM. Positive modulation of α5 GABAA receptors in preadolescence prevents reduced locomotor response to amphetamine in adult female but not male rats prenatally exposed to lipopolysaccharide. International Journal of Developmental Neuroscience : the Official Journal of the International Society For Developmental Neuroscience. 61: 31-39. PMID 28610974 DOI: 10.1016/J.Ijdevneu.2017.06.001  0.491
2017 Witkin JM, Cerne R, Wakulchik M, S J, Gleason SD, Jones TM, Li G, Arnold LA, Li JX, Schkeryantz JM, Methuku KR, Cook JM, Poe MM. Further evaluation of the potential anxiolytic activity of imidazo[1,5-a][1,4]diazepin agents selective for α2/3-containing GABAA receptors. Pharmacology, Biochemistry, and Behavior. PMID 28442369 DOI: 10.1016/J.Pbb.2017.04.009  0.754
2017 Forkuo GS, Nieman AN, Yuan NY, Kodali R, Yu OB, Zahn NM, Jahan R, Li G, Stephen MR, Guthrie ML, Poe MM, Hartzler BD, Harris TW, Yocum GT, Emala CW, et al. Alleviation of Multiple Asthmatic Pathologic Features with Orally Available and Subtype Selective GABAA Receptor Modulators. Molecular Pharmaceutics. PMID 28440659 DOI: 10.1021/Acs.Molpharmaceut.7B00183  0.78
2017 Schwienteck KL, Li G, Poe MM, Cook JM, Banks ML, Stevens Negus S. Abuse-related effects of subtype-selective GABAA receptor positive allosteric modulators in an assay of intracranial self-stimulation in rats. Psychopharmacology. PMID 28365836 DOI: 10.1007/S00213-017-4615-8  0.725
2017 Fischer BD, Schlitt RJ, Hamade BZ, Rehman S, Ernst M, Poe MM, Li G, Kodali R, Arnold LA, Cook JM. Pharmacological and antihyperalgesic properties of the novel α2/3 preferring GABAA receptor ligand MP-III-024. Brain Research Bulletin. PMID 28267561 DOI: 10.1016/J.Brainresbull.2017.03.001  0.782
2017 Kannampalli P, Babygirija R, Zhang J, Poe MM, Li G, M Cook J, Shaker R, Banerjee B, Sengupta JN. Neonatal Bladder Inflammation Induces Long-term Visceral pain and Altered Responses of Spinal Neurons in Adult Rats. Neuroscience. PMID 28126369 DOI: 10.1016/J.Neuroscience.2017.01.021  0.643
2017 Kallay L, Ross A, Moody O, Li G, Cook J, MacDonald T, Jenkins A, Krummel DP, Sengupta S. PATH-50. UNDERSTANDING THE MECHANISM OF BENZODIAZEPINE MEDIATED CELL DEATH IN GABRA5 OVEREXPRESSING GROUP 3 MEDULLOBLASTOMAS Neuro-Oncology. 19: vi182-vi182. DOI: 10.1093/Neuonc/Nox168.739  0.4
2016 Poe MM, Methuku KR, Li G, Verma AR, Teske KA, Stafford DC, Arnold LA, Cramer JW, Jones TM, Cerne R, Krambis MJ, Witkin JM, Jambrina E, Rehman S, Ernst M, et al. Synthesis and Characterization of a Novel γ-Aminobutyric Acid Type A (GABAA) Receptor Ligand That Combines Outstanding Metabolic Stability, Pharmacokinetics, and Anxiolytic Efficacy. Journal of Medicinal Chemistry. 59: 10800-10806. PMID 27933953 DOI: 10.1021/Acs.Jmedchem.6B01332  0.741
2016 Jahan R, Stephen MR, Forkuo GS, Kodali R, Guthrie ML, Nieman AN, Yuan NY, Zahn NM, Poe MM, Li G, Yu OB, Yocum GT, Emala CW, Stafford DC, Cook JM, et al. Optimization of substituted imidazobenzodiazepines as novel asthma treatments. European Journal of Medicinal Chemistry. 126: 550-560. PMID 27915170 DOI: 10.1016/J.Ejmech.2016.11.045  0.762
2016 Forkuo GS, Guthrie ML, Yuan NY, Nieman AN, Kodali R, Jahan R, Yocum GT, Treven M, Stephen MR, Poe MM, Li G, Yu OB, Hartzler BD, Zahn NM, Ernst M, et al. Development of GABAA Receptor Subtype-Selective Imidazobenzodiazepines as Novel Asthma treatments. Molecular Pharmaceutics. PMID 27120014 DOI: 10.1021/Acs.Molpharmaceut.6B00159  0.801
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