Herman P. Spaink - Publications

Leiden University, Leiden, Netherlands 

326 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2021 Nowik N, Prajsnar TK, Przyborowska A, Rakus K, Sienkiewicz W, Spaink HP, Podlasz P. The Role of Galanin during Bacterial Infection in Larval Zebrafish. Cells. 10. PMID 34440783 DOI: 10.3390/cells10082011  1
2021 Keij FM, Koch BEV, Lozano Vigario F, Simons SHP, van Hasselt JGC, Taal HR, Knibbe CAJ, Spaink HP, Reiss IKM, Krekels EHJ. Zebrafish larvae as experimental model to expedite the search for new biomarkers and treatments for neonatal sepsis. Journal of Clinical and Translational Science. 5: e140. PMID 34422320 DOI: 10.1017/cts.2021.803  1
2021 Ding Y, Haks MC, Forn-Cuní G, He J, Nowik N, Harms AC, Hankemeier T, Eeza MNH, Matysik J, Alia A, Spaink HP. Metabolomic and transcriptomic profiling of adult mice and larval zebrafish leptin mutants reveal a common pattern of changes in metabolites and signaling pathways. Cell & Bioscience. 11: 126. PMID 34233759 DOI: 10.1186/s13578-021-00642-0  1
2021 He J, Ding Y, Nowik N, Jager C, H Eeza MN, Alia A, Baelde HJ, Spaink HP. Leptin deficiency affects glucose homeostasis and results in adiposity in zebrafish. The Journal of Endocrinology. PMID 33705349 DOI: 10.1530/JOE-20-0437  1
2021 Hu W, van Steijn L, Li C, Verbeek FJ, Cao L, Merks RMH, Spaink HP. A Novel Function of TLR2 and MyD88 in the Regulation of Leukocyte Cell Migration Behavior During Wounding in Zebrafish Larvae. Frontiers in Cell and Developmental Biology. 9: 624571. PMID 33659250 DOI: 10.3389/fcell.2021.624571  1
2021 Leijten NM, Bakker P, Spaink HP, den Hertog J, Lemeer S. Thermal Proteome Profiling in Zebrafish Reveals Effects of Napabucasin on Retinoic Acid Metabolism. Molecular & Cellular Proteomics : McP. 20: 100033. PMID 33594990 DOI: 10.1074/mcp.RA120.002273  1
2021 Koch BEV, Spaink HP, Meijer AH. A quantitative in vivo assay for craniofacial developmental toxicity of histone deacetylases. Toxicology Letters. PMID 33581288 DOI: 10.1016/j.toxlet.2021.02.005  1
2021 Saxena S, Spaink HP, Forn-Cuní G. Drug Resistance in Nontuberculous Mycobacteria: Mechanisms and Models. Biology. 10. PMID 33573039 DOI: 10.3390/biology10020096  0.01
2021 Hosseini R, Lamers GEM, Bos E, Hogendoorn PCW, Koster AJ, Meijer AH, Spaink HP, Schaaf MJM. The adapter protein Myd88 plays an important role in limiting mycobacterial growth in a zebrafish model for tuberculosis. Virchows Archiv : An International Journal of Pathology. PMID 33559740 DOI: 10.1007/s00428-021-03043-3  1
2021 Utami DT, Tunjung Pratiwi SU, Spaink HP, Haniastuti T, Hertiani T. Antibiofilm effect of C-10 massoia lactone toward polymicrobial oral biofilms. Journal of Advanced Pharmaceutical Technology & Research. 12: 89-93. PMID 33532362 DOI: 10.4103/japtr.JAPTR_105_20  0.01
2021 Liem M, Regensburg-Tuïnk T, Henkel C, Jansen H, Spaink H. Microbial diversity characterization of seawater in a pilot study using Oxford Nanopore Technologies long-read sequencing. Bmc Research Notes. 14: 42. PMID 33531031 DOI: 10.1186/s13104-021-05457-3  1
2021 Meyer A, Schloissnig S, Franchini P, Du K, Woltering J, Irisarri I, Wong WY, Nowoshilow S, Kneitz S, Kawaguchi A, Fabrizius A, Xiong P, Dechaud C, Spaink H, Volff JN, et al. Giant lungfish genome elucidates the conquest of land by vertebrates. Nature. PMID 33461212 DOI: 10.1038/s41586-021-03198-8  1
2020 Leijten NM, Bakker P, Spaink HP, den Hertog J, Lemeer S. Thermal proteome profiling in zebrafish reveals effects of napabucasin on retinoic acid metabolism. Molecular & Cellular Proteomics : McP. PMID 33115751 DOI: 10.1074/mcp.RA120.002273  1
2020 van Wijk RC, Hu W, Dijkema SM, van den Berg DJ, Liu J, Bahi R, Verbeek FJ, Simonsson USH, Spaink HP, van der Graaf PH, Krekels EHJ. Anti-tuberculosis effect of isoniazid scales accurately from zebrafish to humans. British Journal of Pharmacology. PMID 32860631 DOI: 10.1111/Bph.15247  1
2020 Wentzel AS, Petit J, van Veen WG, Fink IR, Scheer MH, Piazzon MC, Forlenza M, Spaink HP, Wiegertjes GF. Transcriptome sequencing supports a conservation of macrophage polarization in fish. Scientific Reports. 10: 13470. PMID 32778701 DOI: 10.1038/S41598-020-70248-Y  1
2020 Ding Y, Raterink RJ, Marín-Juez R, Veneman WJ, Egbers K, van den Eeden S, Haks MC, Joosten SA, Ottenhoff THM, Harms AC, Alia A, Hankemeier T, Spaink HP. Tuberculosis causes highly conserved metabolic changes in human patients, mycobacteria-infected mice and zebrafish larvae. Scientific Reports. 10: 11635. PMID 32669636 DOI: 10.1038/S41598-020-68443-Y  1
2020 Vrieling F, Kostidis S, Spaink HP, Haks MC, Mayboroda OA, Ottenhoff THM, Joosten SA. Analyzing the impact of Mycobacterium tuberculosis infection on primary human macrophages by combined exploratory and targeted metabolomics. Scientific Reports. 10: 7085. PMID 32341411 DOI: 10.1038/S41598-020-62911-1  1
2020 Brinkmann BW, Koch BEV, Spaink HP, Peijnenburg WJGM, Vijver MG. Colonizing microbiota protect zebrafish larvae against silver nanoparticle toxicity. Nanotoxicology. 1-15. PMID 32324436 DOI: 10.1080/17435390.2020.1755469  1
2020 van Wijk RC, van AM, der Sar, Krekels EH, Verboom T, Spaink HP, Simonsson US, van PH, der Graaf. Quantification of natural growth of two strains of Mycobacterium marinum for translational anti-tuberculosis drug development. Clinical and Translational Science. PMID 32267997 DOI: 10.1111/Cts.12793  1
2020 Moreira JD, Koch BEV, van Veen S, Walburg KV, Vrieling F, Mara Pinto Dabés Guimarães T, Meijer AH, Spaink HP, Ottenhoff THM, Haks MC, Heemskerk MT. Functional Inhibition of Host Histone Deacetylases (HDACs) Enhances and Anti-mycobacterial Activity in Human Macrophages and in Zebrafish. Frontiers in Immunology. 11: 36. PMID 32117228 DOI: 10.3389/Fimmu.2020.00036  1
2020 Dervisi I, Valassakis C, Agalou A, Papandreou N, Podia V, Haralampidis K, Iconomidou VA, Kouvelis VN, Spaink HP, Roussis A. Investigation of the interaction of DAD1-LIKE LIPASE 3 (DALL3) with Selenium Binding Protein 1 (SBP1) in Arabidopsis thaliana. Plant Science : An International Journal of Experimental Plant Biology. 291: 110357. PMID 31928671 DOI: 10.1016/J.Plantsci.2019.110357  1
2019 Rougeot J, Torraca V, Zakrzewska A, Kanwal Z, Jansen HJ, Sommer F, Spaink HP, Meijer AH. Corrigendum: RNAseq Profiling of Leukocyte Populations in Zebrafish Larvae Reveals a Chemokine Gene as a Marker of Macrophage Polarization During Mycobacterial Infection. Frontiers in Immunology. 10: 2720. PMID 31832066 DOI: 10.3389/fimmu.2019.02720  1
2019 Hu W, Yang S, Shimada Y, Münch M, Marín-Juez R, Meijer AH, Spaink HP. Infection and RNA-seq analysis of a zebrafish tlr2 mutant shows a broad function of this toll-like receptor in transcriptional and metabolic control and defense to Mycobacterium marinum infection. Bmc Genomics. 20: 878. PMID 31747871 DOI: 10.1186/S12864-019-6265-1  1
2019 Khalil R, Lalai RA, Wiweger MI, Avramut CM, Koster AJ, Spaink HP, Bruijn JA, Hogendoorn PCW, Baelde HJ. Glomerular permeability is not affected by heparan sulfate glycosaminoglycan deficiency in zebrafish embryos. American Journal of Physiology. Renal Physiology. PMID 31461353 DOI: 10.1152/Ajprenal.00126.2019  1
2019 van Wijk RC, Krekels EH, Kantae V, Ordas A, Kreling T, Harms AC, Hankemeier T, Spaink HP, van der Graaf PH. Mechanistic and quantitative understanding of pharmacokinetics in zebrafish larvae through nanoscale blood sampling and metabolite modelling of paracetamol. The Journal of Pharmacology and Experimental Therapeutics. PMID 31371482 DOI: 10.1124/Jpet.119.260299  1
2019 van Steijn L, Verbeek FJ, Spaink HP, Merks RMH. Predicting Metabolism from Gene Expression in an Improved Whole-Genome Metabolic Network Model of . Zebrafish. 16: 348-362. PMID 31216234 DOI: 10.1089/Zeb.2018.1712  1
2019 Jansen HJ, Liem M, Jong-Raadsen SA, Dufour S, Weltzien FA, Swinkels W, Koelewijn A, Palstra AP, Pelster B, Spaink HP, van den Thillart GE, Dirks RP, Henkel CV. Author Correction: Rapid de novo assembly of the European eel genome from nanopore sequencing reads. Scientific Reports. 9: 7911. PMID 31114003 DOI: 10.1038/S41598-019-44275-3  1
2019 Rougeot J, Torraca V, Zakrzewska A, Kanwal Z, Jansen HJ, Sommer F, Spaink HP, Meijer AH. RNAseq Profiling of Leukocyte Populations in Zebrafish Larvae Reveals a Chemokine Gene as a Marker of Macrophage Polarization During Mycobacterial Infection. Frontiers in Immunology. 10: 832. PMID 31110502 DOI: 10.3389/Fimmu.2019.00832  1
2019 Dickmeis T, Feng Y, Mione MC, Ninov N, Santoro M, Spaink HP, Gut P. Nano-Sampling and Reporter Tools to Study Metabolic Regulation in Zebrafish. Frontiers in Cell and Developmental Biology. 7: 15. PMID 30873407 DOI: 10.3389/Fcell.2019.00015  0.01
2019 Henderson F, Johnston HR, Badrock AP, Jones EA, Forster D, Nagaraju RT, Evangelou C, Kamarashev J, Green M, Fairclough M, Barinaga-Rementeria Ramirez I, He S, Snaar-Jagalska BE, Hollywood K, Dunn WB, ... Spaink HP, et al. Enhanced fatty acid scavenging and glycerophospholipid metabolism accompanies melanocyte neoplasia progression in zebrafish. Cancer Research. PMID 30862716 DOI: 10.1158/0008-5472.Can-18-2409  1
2019 Valassakis C, Dervisi I, Agalou A, Papandreou N, Kapetsis G, Podia V, Haralampidis K, Iconomidou VA, Spaink HP, Roussis A. Novel interactions of Selenium Binding Protein family with the PICOT containing proteins AtGRXS14 and AtGRXS16 in Arabidopsis thaliana. Plant Science : An International Journal of Experimental Plant Biology. 281: 102-112. PMID 30824043 DOI: 10.1016/J.Plantsci.2019.01.021  1
2019 van Wijk RC, Krekels EHJ, Kantae V, Harms AC, Hankemeier T, van der Graaf PH, Spaink HP. Impact of post-hatching maturation on the pharmacokinetics of paracetamol in zebrafish larvae. Scientific Reports. 9: 2149. PMID 30770889 DOI: 10.1038/S41598-019-38530-W  1
2019 di Gennaro A, Damiano V, Brisotto G, Armellin M, Perin T, Zucchetto A, Guardascione M, Spaink HP, Doglioni C, Snaar-Jagalska BE, Santarosa M, Maestro R. Correction to: A p53/miR-30a/ZEB2 axis controls triple negative breast cancer aggressiveness. Cell Death and Differentiation. PMID 30728458 DOI: 10.1038/S41418-018-0249-6  1
2019 Koch BEV, Yang S, Lamers G, Stougaard J, Spaink HP. Author Correction: Intestinal microbiome adjusts the innate immune setpoint during colonization through negative regulation of MyD88. Nature Communications. 10: 526. PMID 30692545 DOI: 10.1038/S41467-019-08456-Y  1
2019 Zhang X, de Boer L, Stockhammer OW, Grijpma DW, Spaink HP, Zaat SAJ. A Zebrafish Embryo Model for In Vivo Visualization and Intravital Analysis of Biomaterial-associated Staphylococcus aureus Infection. Journal of Visualized Experiments : Jove. PMID 30663673 DOI: 10.3791/58523  1
2019 Cordero-Maldonado ML, Perathoner S, van der Kolk KJ, Boland R, Heins-Marroquin U, Spaink HP, Meijer AH, Crawford AD, de Sonneville J. Deep learning image recognition enables efficient genome editing in zebrafish by automated injections. Plos One. 14: e0202377. PMID 30615627 DOI: 10.1371/Journal.Pone.0202377  1
2019 Kuo CL, Kallemeijn WW, Lelieveld LT, Mirzaian M, Zoutendijk I, Vardi A, Futerman AH, Meijer AH, Spaink HP, Overkleeft HS, Aerts JMFG, Artola M. In vivo inactivation of glycosidases by conduritol B epoxide and cyclophellitol as revealed by activity-based protein profiling. The Febs Journal. PMID 30600575 DOI: 10.1111/Febs.14744  1
2019 Khalil R, Koop K, Kreutz R, Spaink HP, Hogendoorn PC, Bruijn JA, Baelde HJ. Increased dynamin expression precedes proteinuria in glomerular disease. The Journal of Pathology. 247: 177-185. PMID 30350425 DOI: 10.1002/Path.5181  1
2018 Tudorache C, Slabbekoorn H, Robbers Y, Hin E, Meijer JH, Spaink HP, Schaaf MJM. Biological clock function is linked to proactive and reactive personality types. Bmc Biology. 16: 148. PMID 30577878 DOI: 10.1186/S12915-018-0618-0  1
2018 Castillo-Robles J, Ramírez L, Spaink HP, Lomelí H. smarce1 mutants have a defective endocardium and an increased expression of cardiac transcription factors in zebrafish. Scientific Reports. 8: 15369. PMID 30337622 DOI: 10.1038/S41598-018-33746-8  0.01
2018 Koch BEV, Yang S, Lamers G, Stougaard J, Spaink HP. Intestinal microbiome adjusts the innate immune setpoint during colonization through negative regulation of MyD88. Nature Communications. 9: 4099. PMID 30291253 DOI: 10.1038/S41467-018-06658-4  1
2018 Yang J, Meng Z, Liu Q, Shimada Y, Olsthoorn RCL, Spaink HP, Herrmann A, Kros A. Performing DNA nanotechnology operations on a zebrafish. Chemical Science. 9: 7271-7276. PMID 30288248 DOI: 10.1039/C8Sc01771A  1
2018 Jarque S, Fetter E, Veneman WJ, Spaink HP, Peravali R, Strähle U, Scholz S. An automated screening method for detecting compounds with goitrogenic activity using transgenic zebrafish embryos. Plos One. 13: e0203087. PMID 30157258 DOI: 10.1371/Journal.Pone.0203087  1
2018 Schulthess P, van Wijk RC, Krekels EHJ, Yates JWT, Spaink HP, van der Graaf PH. Outside-In Systems Pharmacology Combines Innovative Computational Methods With High-Throughput Whole Vertebrate Studies. Cpt: Pharmacometrics & Systems Pharmacology. 7: 285-287. PMID 29693322 DOI: 10.1002/psp4.12297  1
2018 di Gennaro A, Damiano V, Brisotto G, Armellin M, Perin T, Zucchetto A, Guardascione M, Spaink HP, Doglioni C, Snaar-Jagalska BE, Santarosa M, Maestro R. A p53/miR-30a/ZEB2 axis controls triple negative breast cancer aggressiveness. Cell Death and Differentiation. 25: 2165-2180. PMID 29666469 DOI: 10.1038/S41418-018-0103-X  1
2018 Locati MD, Pagano JFB, Abdullah F, Ensink WA, van Olst M, van Leeuwen S, Nehrdich U, Spaink HP, Rauwerda H, Jonker MJ, Dekker RJ, Breit T. Identifying small RNAs derived from maternal- and somatic-type rRNAs in Zebrafish Development. Genome. PMID 29425468 DOI: 10.1139/Gen-2017-0202  1
2018 Travin D, Popov I, Guler AT, Medvedev D, van der Plas-Duivesteijn S, Varela M, Kolder ICRM, Meijer AH, Spaink HP, Palmblad M. COMICS: Cartoon Visualization of Omics Data in Spatial Context Using Anatomical Ontologies. Journal of Proteome Research. 17: 739-744. PMID 29083911 DOI: 10.1021/Acs.Jproteome.7B00615  1
2018 Henderson F, Johnston H, Jones E, Foster D, Nagaraju RT, Green M, Fairclough M, Ramirez IB, He S, Snaar-Jagalska BE, Hollywood KA, Dunn W, Spaink HP, Lorigan P, Claude E, et al. Abstract 4109: Multi-modality imaging to interrogate lipidome changes during melanoma progression in zebrafish Cancer Research. 78. DOI: 10.1158/1538-7445.Am2018-4109  1
2017 Jansen HJ, Dirks RP, Liem M, Henkel CV, van Heusden GPH, Lemmers RJLF, Omer T, Shao S, Punt PJ, Spaink HP. whole-genome assembly of a wild type yeast isolate using nanopore sequencing. F1000research. 6: 618. PMID 30135709 DOI: 10.12688/F1000Research.11146.2  1
2017 Jansen HJ, Liem M, Jong-Raadsen SA, Dufour S, Weltzien FA, Swinkels W, Koelewijn A, Palstra AP, Pelster B, Spaink HP, Thillart GEVD, Dirks RP, Henkel CV. Rapid de novo assembly of the European eel genome from nanopore sequencing reads. Scientific Reports. 7: 7213. PMID 28775309 DOI: 10.1038/S41598-017-07650-6  1
2017 Veneman WJ, Spaink HP, Brun NR, Bosker T, Vijver MG. Pathway analysis of systemic transcriptome responses to injected polystyrene particles in zebrafish larvae. Aquatic Toxicology (Amsterdam, Netherlands). 190: 112-120. PMID 28704660 DOI: 10.1016/J.Aquatox.2017.06.014  1
2017 Guo Y, Veneman WJ, Spaink HP, Verbeek FJ. Three-dimensional reconstruction and measurements of zebrafish larvae from high-throughput axial-view in vivo imaging. Biomedical Optics Express. 8: 2611-2634. PMID 28663894 DOI: 10.1364/Boe.8.002611  1
2017 Racz PI, Wildwater M, Rooseboom M, Kerkhof E, Pieters R, Yebra-Pimentel ES, Dirks RP, Spaink HP, Smulders C, Whale GF. Application of Caenorhabditis elegans (nematode) and Danio rerio embryo (zebrafish) as model systems to screen for developmental and reproductive toxicity of Piperazine compounds. Toxicology in Vitro : An International Journal Published in Association With Bibra. PMID 28595837 DOI: 10.1016/J.Tiv.2017.06.002  1
2017 Zhang X, Stockhammer OW, de Boer L, Vischer NOE, Spaink HP, Grijpma DW, Zaat SAJ. The zebrafish embryo as a model to quantify early inflammatory cell responses to biomaterials. Journal of Biomedical Materials Research. Part A. PMID 28509403 DOI: 10.1002/Jbm.A.36110  1
2017 Locati MD, Pagano JFB, Girard G, Ensink WA, van Olst M, van Leeuwen S, Nehrdich U, Spaink HP, Rauwerda H, Jonker MJ, Dekker RJ, Breit TM. Expression of distinct maternal and somatic 5.8S, 18S, and 28S rRNA types during zebrafish development. Rna (New York, N.Y.). 23: 1188-1199. PMID 28500251 DOI: 10.1261/Rna.061515.117  1
2017 Zhu K, Spaink HP, Durston AJ. Hoxc6 Loss of Function Truncates the Main Body Axis in Xenopus. Cell Cycle (Georgetown, Tex.). 0. PMID 28471288 DOI: 10.1080/15384101.2017.1317415  1
2017 Rauwerda H, Pagano JF, de Leeuw WC, Ensink W, Nehrdich U, de Jong M, Jonker M, Spaink HP, Breit TM. Transcriptome dynamics in early zebrafish embryogenesis determined by high-resolution time course analysis of 180 successive, individual zebrafish embryos. Bmc Genomics. 18: 287. PMID 28399811 DOI: 10.1186/S12864-017-3672-Z  1
2017 Zhu K, Spaink HP, Durston AJ. Collinear Hox-Hox interactions are involved in patterning the vertebrate anteroposterior (A-P) axis. Plos One. 12: e0175287. PMID 28399140 DOI: 10.1371/Journal.Pone.0175287  1
2017 Chatzopoulou A, Schoonheim PJ, Torraca V, Meijer AH, Spaink HP, Schaaf MJ. Functional analysis reveals no transcriptional role for the glucocorticoid receptor β-isoform in zebrafish. Molecular and Cellular Endocrinology. PMID 28242321 DOI: 10.1016/J.Mce.2017.02.036  1
2017 Rooseboom M, Wildwater M, Currie R, Dirks RP, Kerkhof E, Haar JLd, Maxwell S, Pears C, Pijnenburg D, Racz P, Ruijtenbeek R, Smulders C, Spaink H, Warren E, Whale G, et al. Combinatorial model organism strategy to predict developmental and reproductive toxicology (DART) Toxicology Letters. 280. DOI: 10.1016/J.Toxlet.2017.07.258  1
2017 Zhu K, Spaink H, Durston A. PS2.104Regulation of Hox gene expression during anteroposterior patterning involves collinear Hox-Hox interactions Mechanisms of Development. 145. DOI: 10.1016/J.Mod.2017.04.204  1
2016 Locati MD, Pagano JF, Ensink WA, van Olst M, van Leeuwen S, Nehrdich U, Zhu K, Spaink HP, Girard G, Rauwerda H, Jonker MJ, Dekker RJ, Breit TM. Linking Maternal and Somatic 5S rRNA types with Different Sequence-Specific Non-LTR Retrotransposons. Rna (New York, N.Y.). PMID 28003516 DOI: 10.1261/Rna.059642.116  1
2016 Kantae V, Krekels EH, Ordas A, González O, van Wijk RC, Harms AC, Racz PI, van der Graaf PH, Spaink HP, Hankemeier T. Pharmacokinetic Modeling of Paracetamol Uptake and Clearance in Zebrafish Larvae: Expanding the Allometric Scale in Vertebrates with Five Orders of Magnitude. Zebrafish. PMID 27632065 DOI: 10.1089/zeb.2016.1313  1
2016 Kolder IC, van der Plas-Duivesteijn SJ, Tan G, Wiegertjes GF, Forlenza M, Guler AT, Travin DY, Nakao M, Moritomo T, Irnazarow I, den Dunnen JT, Anvar SY, Jansen HJ, Dirks RP, Palmblad M, ... ... Spaink HP, et al. A full-body transcriptome and proteome resource for the European common carp. Bmc Genomics. 17: 701. PMID 27590662 DOI: 10.1186/S12864-016-3038-Y  1
2016 Yang J, Shimada Y, Olsthoorn RC, Snaar-Jagalska BE, Spaink HP, Kros A. Application of Coiled Coil Peptides in Liposomal Anti-Cancer Drug Delivery Using a Zebrafish Xenograft Model. Acs Nano. PMID 27504667 DOI: 10.1021/Acsnano.6B01410  1
2016 Benard EL, Rougeot J, Racz PI, Spaink HP, Meijer AH. Transcriptomic Approaches in the Zebrafish Model for Tuberculosis-Insights Into Host- and Pathogen-specific Determinants of the Innate Immune Response. Advances in Genetics. 95: 217-251. PMID 27503359 DOI: 10.1016/Bs.Adgen.2016.04.004  1
2016 Hosseini R, Lamers GE, Soltani HM, Meijer AH, Spaink HP, Schaaf MJ. Efferocytosis and extrusion of leukocytes determine the progression of early mycobacterial pathogenesis. Journal of Cell Science. 129: 3385-95. PMID 27469488 DOI: 10.1242/Jcs.135194  1
2016 Tulotta C, He S, Chen L, Groenewoud A, van der Ent W, Meijer AH, Spaink HP, Snaar-Jagalska BE. Imaging of Human Cancer Cell Proliferation, Invasion, and Micrometastasis in a Zebrafish Xenogeneic Engraftment Model. Methods in Molecular Biology (Clifton, N.J.). 1451: 155-69. PMID 27464807 DOI: 10.1007/978-1-4939-3771-4_11  1
2016 Pagano JF, Rauwerda H, de Leeuw WC, Wackers P, de Jong M, Ensink W, Dekker R, Nehrdich U, Spaink HP, Jonker M, Breit TM. Transcriptome data on maternal RNA of 24 individual zebrafish eggs from five sibling mothers. Data in Brief. 8: 69-72. PMID 27284564 DOI: 10.1016/J.Dib.2016.04.045  1
2016 Chatzopoulou A, Heijmans JP, Burgerhout E, Oskam N, Spaink HP, Meijer AH, Schaaf MJ. Glucocorticoid-induced attenuation of the inflammatory response in zebrafish. Endocrinology. en20152050. PMID 27219276 DOI: 10.1210/En.2015-2050  1
2016 van der Ent W, Veneman WJ, Groenewoud A, Chen L, Tulotta C, Hogendoorn PC, Spaink HP, Snaar-Jagalska BE. Automation of Technology for Cancer Research. Advances in Experimental Medicine and Biology. 916: 315-32. PMID 27165360 DOI: 10.1007/978-3-319-30654-4_14  1
2016 Tulotta C, He S, van der Ent W, Chen L, Groenewoud A, Spaink HP, Snaar-Jagalska BE. Imaging Cancer Angiogenesis and Metastasis in a Zebrafish Embryo Model. Advances in Experimental Medicine and Biology. 916: 239-63. PMID 27165357 DOI: 10.1007/978-3-319-30654-4_11  1
2016 Klionsky DJ, Abdelmohsen K, Abe A, Abedin J, Abeliovich H, Arozena AA, Adachi H, Adams CM, Adams PD, Adeli K, Adhihetty PJ, Adler SG, Agam G, Agarwal R, Aghi MK, ... ... Spaink HP, et al. Erratum to: Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition) (Autophagy, 12, 1, 1-222, 10.1080/15548627.2015.1100356 Autophagy. 12: 443-443. PMID 26902590 DOI: 10.1080/15548627.2016.1147886  1
2016 Rauwerda H, Wackers P, Pagano JF, de Jong M, Ensink W, Dekker R, Nehrdich U, Spaink HP, Jonker M, Breit TM. Mother-Specific Signature in the Maternal Transcriptome Composition of Mature, Unfertilized Zebrafish Eggs. Plos One. 11: e0147151. PMID 26799215 DOI: 10.1371/Journal.Pone.0147151  1
2016 Staal FJ, Spaink HP, Fibbe WE. Visualizing Human Hematopoietic Stem Cell Trafficking In Vivo Using a Zebrafish Xenograft Model. Stem Cells and Development. 25: 360-5. PMID 26650921 DOI: 10.1089/Scd.2015.0195  0.01
2016 Wiegertjes GF, Wentzel AS, Spaink HP, Elks PM, Fink IR. Polarization of immune responses in fish: The 'macrophages first' point of view. Molecular Immunology. 69: 146-56. PMID 26471699 DOI: 10.1016/J.Molimm.2015.09.026  1
2016 Wijk RCv, Krekels EHJ, Hankemeier T, Spaink HP, Graaf PHvd. Systems pharmacology of hepatic metabolism in zebrafish larvae Drug Discovery Today: Disease Models. 22: 27-34. DOI: 10.1016/J.Ddmod.2017.04.003  1
2015 Burgerhout E, Minegishi Y, Brittijn SA, de Wijze DL, Henkel CV, Jansen HJ, Spaink HP, Dirks RP, van den Thillart GE. Changes in ovarian gene expression profiles and plasma hormone levels in maturing European eel (Anguilla anguilla); Biomarkers for broodstock selection. General and Comparative Endocrinology. PMID 26255685 DOI: 10.1016/J.Ygcen.2015.08.006  1
2015 Yang S, Marín-Juez R, Meijer AH, Spaink HP. Common and specific downstream signaling targets controlled by Tlr2 and Tlr5 innate immune signaling in zebrafish. Bmc Genomics. 16: 547. PMID 26208853 DOI: 10.1186/S12864-015-1740-9  1
2015 Locati MD, Terpstra I, de Leeuw WC, Kuzak M, Rauwerda H, Ensink WA, van Leeuwen S, Nehrdich U, Spaink HP, Jonker MJ, Breit TM, Dekker RJ. Improving small RNA-seq by using a synthetic spike-in set for size-range quality control together with a set for data normalization. Nucleic Acids Research. 43: e89. PMID 25870415 DOI: 10.1093/Nar/Gkv303  1
2015 Chatzopoulou A, Roy U, Meijer AH, Alia A, Spaink HP, Schaaf MJ. Transcriptional and metabolic effects of glucocorticoid receptor α and β signaling in zebrafish. Endocrinology. 156: 1757-69. PMID 25756310 DOI: 10.1210/En.2014-1941  1
2015 Koch BE, Stougaard J, Spaink HP. Keeping track of the growing number of biological functions of chitin and its interaction partners in biomedical research. Glycobiology. 25: 469-82. PMID 25595947 DOI: 10.1093/Glycob/Cwv005  1
2015 Torraca V, Cui C, Boland R, Bebelman JP, van der Sar AM, Smit MJ, Siderius M, Spaink HP, Meijer AH. The CXCR3-CXCL11 signaling axis mediates macrophage recruitment and dissemination of mycobacterial infection. Disease Models & Mechanisms. 8: 253-69. PMID 25573892 DOI: 10.1242/Dmm.017756  1
2015 Veneman WJ, de Sonneville J, van der Kolk KJ, Ordas A, Al-Ars Z, Meijer AH, Spaink HP. Analysis of RNAseq datasets from a comparative infectious disease zebrafish model using GeneTiles bioinformatics. Immunogenetics. 67: 135-47. PMID 25503064 DOI: 10.1007/S00251-014-0820-3  1
2015 Ordas A, Raterink RJ, Cunningham F, Jansen HJ, Wiweger MI, Jong-Raadsen S, Bos S, Bates RH, Barros D, Meijer AH, Vreeken RJ, Ballell-Pages L, Dirks RP, Hankemeier T, Spaink HP. Testing tuberculosis drug efficacy in a zebrafish high-throughput translational medicine screen. Antimicrobial Agents and Chemotherapy. 59: 753-62. PMID 25385118 DOI: 10.1128/Aac.03588-14  1
2015 Jiménez-Amilburu V, Jong-Raadsen S, Bakkers J, Spaink HP, Marín-Juez R. GLUT12 deficiency during early development results in heart failure and a diabetic phenotype in zebrafish. The Journal of Endocrinology. 224: 1-15. PMID 25326603 DOI: 10.1530/Joe-14-0539  1
2015 Marín-Juez R, Rovira M, Crespo D, van der Vaart M, Spaink HP, Planas JV. GLUT2-mediated glucose uptake and availability are required for embryonic brain development in zebrafish. Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism. 35: 74-85. PMID 25294126 DOI: 10.1038/Jcbfm.2014.171  1
2015 Benard EL, Racz PI, Rougeot J, Nezhinsky AE, Verbeek FJ, Spaink HP, Meijer AH. Macrophage-expressed perforins mpeg1 and mpeg1.2 have an anti-bacterial function in zebrafish. Journal of Innate Immunity. 7: 136-52. PMID 25247677 DOI: 10.1159/000366103  1
2015 Spaink H, Racz P, Ordas A, Veneman W, Vijver M, Wildwater M, Pieters R, Zope H, Kros A, Kantae V, Krekels E, Graaf PHvd, Hankemeier T. Automated zebrafish toxicology screening: Effect assessment and uptake studies Toxicology Letters. 238. DOI: 10.1016/J.Toxlet.2015.08.150  1
2014 Palstra AP, Rovira M, Rizo-Roca D, Torrella JR, Spaink HP, Planas JV. Swimming-induced exercise promotes hypertrophy and vascularization of fast skeletal muscle fibres and activation of myogenic and angiogenic transcriptional programs in adult zebrafish. Bmc Genomics. 15: 1136. PMID 25518849 DOI: 10.1186/1471-2164-15-1136  1
2014 Jacobs CG, Spaink HP, van der Zee M. The extraembryonic serosa is a frontier epithelium providing the insect egg with a full-range innate immune response. Elife. 3. PMID 25487990 DOI: 10.7554/Elife.04111  0.01
2014 Ummels R, Abdallah AM, Kuiper V, Aâjoud A, Sparrius M, Naeem R, Spaink HP, van Soolingen D, Bitter W, Pain A. Identification of a novel conjugative plasmid in mycobacteria that requires both type IV and type VII secretion Mbio. 5. PMID 25249284 DOI: 10.1128/Mbio.01744-14  1
2014 Rougeot J, Zakrzewska A, Kanwal Z, Jansen HJ, Spaink HP, Meijer AH. RNA sequencing of FACS-sorted immune cell populations from zebrafish infection models to identify cell specific responses to intracellular pathogens. Methods in Molecular Biology (Clifton, N.J.). 1197: 261-74. PMID 25172286 DOI: 10.1007/978-1-4939-1261-2_15  1
2014 Hosseini R, Lamers GE, Hodzic Z, Meijer AH, Schaaf MJ, Spaink HP. Correlative light and electron microscopy imaging of autophagy in a zebrafish infection model. Autophagy. 10: 1844-57. PMID 25126731 DOI: 10.4161/Auto.29992  1
2014 Benard EL, Roobol SJ, Spaink HP, Meijer AH. Phagocytosis of mycobacteria by zebrafish macrophages is dependent on the scavenger receptor Marco, a key control factor of pro-inflammatory signalling. Developmental and Comparative Immunology. 47: 223-33. PMID 25086293 DOI: 10.1016/J.Dci.2014.07.022  1
2014 Veneman WJ, Marín-Juez R, de Sonneville J, Ordas A, Jong-Raadsen S, Meijer AH, Spaink HP. Establishment and optimization of a high throughput setup to study Staphylococcus epidermidis and Mycobacterium marinum infection as a model for drug discovery. Journal of Visualized Experiments : Jove. e51649. PMID 24998295 DOI: 10.3791/51649  1
2014 Dirks RP, Burgerhout E, Brittijn SA, de Wijze DL, Ozupek H, Tuinhof-Koelma N, Minegishi Y, Jong-Raadsen SA, Spaink HP, van den Thillart GEEJM. Identification of molecular markers in pectoral fin to predict artificial maturation of female European eels (Anguilla anguilla) General and Comparative Endocrinology. 204: 267-276. PMID 24992558 DOI: 10.1016/J.Ygcen.2014.06.023  1
2014 van der Ent W, Jochemsen AG, Teunisse AF, Krens SF, Szuhai K, Spaink HP, Hogendoorn PC, Snaar-Jagalska BE. Ewing sarcoma inhibition by disruption of EWSR1-FLI1 transcriptional activity and reactivation of p53. The Journal of Pathology. 233: 415-24. PMID 24974828 DOI: 10.1002/Path.4378  1
2014 Torraca V, Masud S, Spaink HP, Meijer AH. Macrophage-pathogen interactions in infectious diseases: New therapeutic insights from the zebrafish host model Dmm Disease Models and Mechanisms. 7: 785-797. PMID 24973749 DOI: 10.1242/Dmm.015594  1
2014 Elks PM, van der Vaart M, van Hensbergen V, Schutz E, Redd MJ, Murayama E, Spaink HP, Meijer AH. Mycobacteria counteract a TLR-mediated nitrosative defense mechanism in a zebrafish infection model. Plos One. 9: e100928. PMID 24967596 DOI: 10.1371/Journal.Pone.0100928  1
2014 van der Vaart M, Korbee CJ, Lamers GE, Tengeler AC, Hosseini R, Haks MC, Ottenhoff TH, Spaink HP, Meijer AH. The DNA damage-regulated autophagy modulator DRAM1 links mycobacterial recognition via TLR-MYD88 to autophagic defense [corrected]. Cell Host & Microbe. 15: 753-67. PMID 24922577 DOI: 10.1016/J.Chom.2014.05.005  1
2014 Marín-Juez R, Jong-Raadsen S, Yang S, Spaink HP. Hyperinsulinemia induces insulin resistance and immune suppression via Ptpn6/Shp1 in zebrafish. The Journal of Endocrinology. 222: 229-41. PMID 24904114 DOI: 10.1530/Joe-14-0178  1
2014 van Amerongen YF, Roy U, Spaink HP, de Groot HJ, Huster D, Schiller J, Alia A. Zebrafish brain lipid characterization and quantification by ¹H nuclear magnetic resonance spectroscopy and MALDI-TOF mass spectrometry. Zebrafish. 11: 240-7. PMID 24707799 DOI: 10.1089/zeb.2013.0955  1
2014 Briolat V, Jouneau L, Carvalho R, Palha N, Langevin C, Herbomel P, Schwartz O, Spaink HP, Levraud JP, Boudinot P. Contrasted innate responses to two viruses in zebrafish: insights into the ancestral repertoire of vertebrate IFN-stimulated genes. Journal of Immunology (Baltimore, Md. : 1950). 192: 4328-41. PMID 24683187 DOI: 10.4049/Jimmunol.1302611  1
2014 Kanwal Z, Wiegertjes GF, Veneman WJ, Meijer AH, Spaink HP. Comparative studies of Toll-like receptor signalling using zebrafish. Developmental and Comparative Immunology. 46: 35-52. PMID 24560981 DOI: 10.1016/J.Dci.2014.02.003  1
2014 van der Plas-Duivesteijn SJ, Mohammed Y, Dalebout H, Meijer A, Botermans A, Hoogendijk JL, Henneman AA, Deelder AM, Spaink HP, Palmblad M. Identifying proteins in zebrafish embryos using spectral libraries generated from dissected adult organs and tissues. Journal of Proteome Research. 13: 1537-44. PMID 24460240 DOI: 10.1021/Pr4010585  1
2014 Koch BE, Stougaard J, Spaink HP. Spatial and temporal expression patterns of chitinase genes in developing zebrafish embryos. Gene Expression Patterns : Gep. 14: 69-77. PMID 24418193 DOI: 10.1016/J.Gep.2014.01.001  1
2014 Pietretti D, Scheer M, Fink IR, Taverne N, Savelkoul HF, Spaink HP, Forlenza M, Wiegertjes GF. Identification and functional characterization of nonmammalian Toll-like receptor 20. Immunogenetics. 66: 123-41. PMID 24327191 DOI: 10.1007/S00251-013-0751-4  1
2014 Spaink HP, Jansen HJ, Dirks RP. Advances in genomics of bony fish. Briefings in Functional Genomics. 13: 144-56. PMID 24291769 DOI: 10.1093/Bfgp/Elt046  1
2014 Meijer AH, van der Vaart M, Spaink HP. Real-time imaging and genetic dissection of host-microbe interactions in zebrafish. Cellular Microbiology. 16: 39-49. PMID 24188444 DOI: 10.1111/Cmi.12236  1
2014 Jacobs CGC, Spaink HP, Zee Mvd. Author response: The extraembryonic serosa is a frontier epithelium providing the insect egg with a full-range innate immune response Elife. DOI: 10.7554/Elife.04111.023  0.01
2014 Elks PM, Van Der Vaart M, Van Hensbergen V, Schutz E, Redd MJ, Murayama E, Spaink HP, Meijer AH. Mycobacteria counteract a TLR-mediated nitrosative defense mechanism in a zebrafish infection model Plos One. 9. DOI: 10.1371/journal.pone.0100928  1
2013 Vonk FJ, Casewell NR, Henkel CV, Heimberg AM, Jansen HJ, McCleary RJ, Kerkkamp HM, Vos RA, Guerreiro I, Calvete JJ, Wüster W, Woods AE, Logan JM, Harrison RA, Castoe TA, ... ... Spaink HP, et al. The king cobra genome reveals dynamic gene evolution and adaptation in the snake venom system. Proceedings of the National Academy of Sciences of the United States of America. 110: 20651-6. PMID 24297900 DOI: 10.1073/Pnas.1314702110  1
2013 Zope HR, Versluis F, Ordas A, Voskuhl J, Spaink HP, Kros A. In vitro and in vivo supramolecular modification of biomembranes using a lipidated coiled-coil motif. Angewandte Chemie (International Ed. in English). 52: 14247-51. PMID 24214899 DOI: 10.1002/Anie.201306033  1
2013 Palmblad M, Henkel CV, Dirks RP, Meijer AH, Deelder AM, Spaink HP. Parallel deep transcriptome and proteome analysis of zebrafish larvae. Bmc Research Notes. 6: 428. PMID 24156766 DOI: 10.1186/1756-0500-6-428  1
2013 Ager-Wick E, Dirks RP, Burgerhout E, Nourizadeh-Lillabadi R, de Wijze DL, Spaink HP, van den Thillart GE, Tsukamoto K, Dufour S, Weltzien FA, Henkel CV. The pituitary gland of the European eel reveals massive expression of genes involved in the melanocortin system. Plos One. 8: e77396. PMID 24130881 DOI: 10.1371/Journal.Pone.0077396  1
2013 Ordas A, Kanwal Z, Lindenberg V, Rougeot J, Mink M, Spaink HP, Meijer AH. MicroRNA-146 function in the innate immune transcriptome response of zebrafish embryos to Salmonella typhimurium infection. Bmc Genomics. 14: 696. PMID 24112639 DOI: 10.1186/1471-2164-14-696  1
2013 Pietretti D, Spaink HP, Falco A, Forlenza M, Wiegertjes GF. Accessory molecules for Toll-like receptors in Teleost fish. Identification of TLR4 interactor with leucine-rich repeats (TRIL). Molecular Immunology. 56: 745-56. PMID 23958499 DOI: 10.1016/J.Molimm.2013.07.012  1
2013 Spaink HP, Cui C, Wiweger MI, Jansen HJ, Veneman WJ, Marín-Juez R, de Sonneville J, Ordas A, Torraca V, van der Ent W, Leenders WP, Meijer AH, Snaar-Jagalska BE, Dirks RP. Robotic injection of zebrafish embryos for high-throughput screening in disease models. Methods (San Diego, Calif.). 62: 246-54. PMID 23769806 DOI: 10.1016/J.Ymeth.2013.06.002  1
2013 Veneman WJ, Stockhammer OW, de Boer L, Zaat SA, Meijer AH, Spaink HP. A zebrafish high throughput screening system used for Staphylococcus epidermidis infection marker discovery. Bmc Genomics. 14: 255. PMID 23586901 DOI: 10.1186/1471-2164-14-255  1
2013 Laroche FJF, Tulotta C, Lamers GEM, Meijer AH, Yang P, Verbeek FJ, Blaise M, Stougaard J, Spaink HP. The embryonic expression patterns of zebrafish genes encoding LysM-domains. Gene Expression Patterns. 13: 212-224. PMID 23567754 DOI: 10.1016/J.Gep.2013.02.007  1
2013 Driessen M, Kienhuis AS, Pennings JL, Pronk TE, van de Brandhof EJ, Roodbergen M, Spaink HP, van de Water B, van der Ven LT. Exploring the zebrafish embryo as an alternative model for the evaluation of liver toxicity by histopathology and expression profiling. Archives of Toxicology. 87: 807-23. PMID 23559145 DOI: 10.1007/S00204-013-1039-Z  1
2013 van der Vaart M, van Soest JJ, Spaink HP, Meijer AH. Functional analysis of a zebrafish myd88 mutant identifies key transcriptional components of the innate immune system. Disease Models & Mechanisms. 6: 841-54. PMID 23471913 DOI: 10.1242/Dmm.010843  1
2013 Kanwal Z, Zakrzewska A, den Hertog J, Spaink HP, Schaaf MJ, Meijer AH. Deficiency in hematopoietic phosphatase ptpn6/Shp1 hyperactivates the innate immune system and impairs control of bacterial infections in zebrafish embryos. Journal of Immunology (Baltimore, Md. : 1950). 190: 1631-45. PMID 23335748 DOI: 10.4049/Jimmunol.1200551  1
2013 Palstra AP, Beltran S, Burgerhout E, Brittijn SA, Magnoni LJ, Henkel CV, Jansen HJ, van den Thillart GE, Spaink HP, Planas JV. Deep RNA sequencing of the skeletal muscle transcriptome in swimming fish. Plos One. 8: e53171. PMID 23308156 DOI: 10.1371/Journal.Pone.0053171  1
2013 Rian H, Krens SFG, Spaink HP, Snaar-Jagalska BE. Generation of Constitutive Active ERK Mutants as Tools for Cancer Research in Zebrafish International Scholarly Research Notices. 2013: 867613. DOI: 10.1155/2013/867613  1
2013 Raterink R, Kloet FMvd, Li J, Wattel NA, Schaaf MJM, Spaink HP, Berger R, Vreeken RJ, Hankemeier T. Rapid metabolic screening of early zebrafish embryogenesis based on direct infusion-nanoESI-FTMS Metabolomics. 9: 864-873. DOI: 10.1007/S11306-012-0493-6  1
2013 Zope HR, Versluis F, Ordas A, Voskuhl J, Spaink HP, Kros A. Supramolekulare In‐vitro‐ und In‐vivo‐Funktionalisierung von Biomembranen durch ein lipidiertes Coiled‐Coil‐Bindungsmotiv Angewandte Chemie. 125: 14497-14501. DOI: 10.1002/Ange.201306033  1
2012 Henkel CV, Dirks RP, de Wijze DL, Minegishi Y, Aoyama J, Jansen HJ, Turner B, Knudsen B, Bundgaard M, Hvam KL, Boetzer M, Pirovano W, Weltzien FA, Dufour S, Tsukamoto K, ... Spaink HP, et al. First draft genome sequence of the Japanese eel, Anguilla japonica. Gene. 511: 195-201. PMID 23026207 DOI: 10.1016/J.Gene.2012.09.064  1
2012 van der Vaart M, Spaink HP, Meijer AH. Pathogen recognition and activation of the innate immune response in zebrafish. Advances in Hematology. 2012: 159807. PMID 22811714 DOI: 10.1155/2012/159807  1
2012 Henkel CV, Dirks RP, Jansen HJ, Forlenza M, Wiegertjes GF, Howe K, van den Thillart GE, Spaink HP. Comparison of the exomes of common carp (Cyprinus carpio) and zebrafish (Danio rerio). Zebrafish. 9: 59-67. PMID 22715948 DOI: 10.1089/Zeb.2012.0773  1
2012 Schartl M, Kneitz S, Wilde B, Wagner T, Henkel CV, Spaink HP, Meierjohann S. Conserved expression signatures between medaka and human pigment cell tumors. Plos One. 7: e37880. PMID 22693581 DOI: 10.1371/Journal.Pone.0037880  1
2012 Minegishi Y, Dirks RP, de Wijze DL, Brittijn SA, Burgerhout E, Spaink HP, van den Thillart GEEJM. Quantitative bioassays for measuring biologically functional gonadotropins based on eel gonadotropic receptors General and Comparative Endocrinology. 178: 145-152. PMID 22580328 DOI: 10.1016/J.Ygcen.2012.04.030  1
2012 Benard EL, van der Sar AM, Ellett F, Lieschke GJ, Spaink HP, Meijer AH. Infection of zebrafish embryos with intracellular bacterial pathogens Journal of Visualized Experiments : Jove. PMID 22453760 DOI: 10.3791/3781  1
2012 Blaise M, Alsarraf HMAB, Wong JEMM, Midtgaard SR, Laroche F, Schack L, Spaink H, Stougaard J, Thirup S. Crystal structure of the TLDc domain of oxidation resistance protein 2 from zebrafish. Proteins. 80: 1694-1698. PMID 22434723 DOI: 10.1002/Prot.24050  1
2012 Henkel CV, Burgerhout E, de Wijze DL, Dirks RP, Minegishi Y, Jansen HJ, Spaink HP, Dufour S, Weltzien FA, Tsukamoto K, van den Thillart GE. Primitive duplicate Hox clusters in the European eel's genome. Plos One. 7: e32231. PMID 22384188 DOI: 10.1371/Journal.Pone.0032231  1
2012 He S, Lamers GE, Beenakker JW, Cui C, Ghotra VP, Danen EH, Meijer AH, Spaink HP, Snaar-Jagalska BE. Neutrophil-mediated experimental metastasis is enhanced by VEGFR inhibition in a zebrafish xenograft model. The Journal of Pathology. 227: 431-45. PMID 22374800 DOI: 10.1002/Path.4013  1
2012 Ghotra VP, He S, de Bont H, van der Ent W, Spaink HP, van de Water B, Snaar-Jagalska BE, Danen EH. Automated whole animal bio-imaging assay for human cancer dissemination. Plos One. 7: e31281. PMID 22347456 DOI: 10.1371/Journal.Pone.0031281  1
2012 Mohseny AB, Xiao W, Carvalho R, Spaink HP, Hogendoorn PC, Cleton-Jansen AM. An osteosarcoma zebrafish model implicates Mmp-19 and Ets-1 as well as reduced host immune response in angiogenesis and migration. The Journal of Pathology. 227: 245-53. PMID 22297719 DOI: 10.1002/Path.3998  1
2012 Ghotra VPS, E SH, Bont HD, Spaink HP, Water BVd, Jagalska BES, Danen EHJ. Abstract C52: Semi-high-throughput whole-animal bioimaging assay identifies novel players in prostate cancer progression Cancer Research. 72. DOI: 10.1158/1538-7445.Prca2012-C52  1
2012 Zhou X, Laroche F, Lamers GEM, Torraca V, Voskamp P, Lu T, Chu F, Spaink HP, Abrahams JP, Liu Z. Ultra-small graphene oxide functionalized with polyethylenimine (PEI) for very efficient gene delivery in cell and zebrafish embryos Nano Research. 5: 703-709. DOI: 10.1007/S12274-012-0254-X  1
2011 Alsarraf HMAB, Laroche F, Spaink H, Thirup S, Blaise M. Purification, crystallization and preliminary crystallographic studies of the TLDc domain of oxidation resistance protein 2 from zebrafish. Acta Crystallographica Section F-Structural Biology and Crystallization Communications. 67: 1253-1256. PMID 22102041 DOI: 10.1107/S1744309111027990  1
2011 van Soest JJ, Stockhammer OW, Ordas A, Bloemberg GV, Spaink HP, Meijer AH. Comparison of static immersion and intravenous injection systems for exposure of zebrafish embryos to the natural pathogen Edwardsiella tarda. Bmc Immunology. 12: 58. PMID 22003892 DOI: 10.1186/1471-2172-12-58  1
2011 Cui C, Benard EL, Kanwal Z, Stockhammer OW, van der Vaart M, Zakrzewska A, Spaink HP, Meijer AH. Infectious disease modeling and innate immune function in zebrafish embryos. Methods in Cell Biology. 105: 273-308. PMID 21951535 DOI: 10.1016/B978-0-12-381320-6.00012-6  1
2011 Zhang Y, Stupka E, Henkel CV, Jansen HJ, Spaink HP, Verbeek FJ. Identification of common carp innate immune genes with whole-genome sequencing and RNA-Seq data. Journal of Integrative Bioinformatics. 8: 169. PMID 21908900 DOI: 10.2390/Biecoll-Jib-2011-169  1
2011 He S, Krens SG, Zhan H, Gong Z, Hogendoorn PC, Spaink HP, Snaar-Jagalska BE. A ΔRaf1-ER-inducible oncogenic zebrafish liver cell model identifies hepatocellular carcinoma signatures. The Journal of Pathology. 225: 19-28. PMID 21744342 DOI: 10.1002/Path.2936  1
2011 Rotman J, van Gils W, Butler D, Spaink HP, Meijer AH. Rapid screening of innate immune gene expression in zebrafish using reverse transcription - multiplex ligation-dependent probe amplification. Bmc Research Notes. 4: 196. PMID 21676242 DOI: 10.1186/1756-0500-4-196  1
2011 Ali S, Champagne DL, Spaink HP, Richardson MK. Zebrafish embryos and larvae: a new generation of disease models and drug screens. Birth Defects Research. Part C, Embryo Today : Reviews. 93: 115-33. PMID 21671352 DOI: 10.1002/Bdrc.20206  1
2011 Sergé A, de Keijzer S, Van Hemert F, Hickman MR, Hereld D, Spaink HP, Schmidt T, Snaar-Jagalska BE. Quantification of GPCR internalization by single-molecule microscopy in living cells. Integrative Biology : Quantitative Biosciences From Nano to Macro. 3: 675-83. PMID 21541374 DOI: 10.1039/C0Ib00121J  1
2011 Burgerhout E, Brittijn SA, Kurwie T, Decker P, Dirks RP, Palstra AP, Spaink HP, Van Den Thillart GE. First artificial hybrid of the eel species Anguilla australis and Anguilla anguilla Bmc Developmental Biology. 11. PMID 21396126 DOI: 10.1186/1471-213X-11-16  1
2011 Carvalho R, de Sonneville J, Stockhammer OW, Savage NDL, Veneman WJ, Ottenhoff THM, Dirks RP, Meijer AH, Spaink HP. A high-throughput screen for tuberculosis progression Plos One. 6. PMID 21390204 DOI: 10.1371/Journal.Pone.0016779  1
2011 Meijer AH, Spaink HP. Host-Pathogen Interactions Made Transparent with the Zebrafish Model Current Drug Targets. 12: 1000-1017. PMID 21366518 DOI: 10.2174/138945011795677809  1
2011 Harrison MR, Georgiou AS, Spaink HP, Cunliffe VT. The epigenetic regulator Histone Deacetylase 1 promotes transcription of a core neurogenic programme in zebrafish embryos. Bmc Genomics. 12: 24. PMID 21226904 DOI: 10.1186/1471-2164-12-24  1
2011 Ordas A, Hegedus Z, Henkel CV, Stockhammer OW, Butler D, Jansen HJ, Racz P, Mink M, Spaink HP, Meijer AH. Deep sequencing of the innate immune transcriptomic response of zebrafish embryos to Salmonella infection. Fish & Shellfish Immunology. 31: 716-24. PMID 20816807 DOI: 10.1016/J.Fsi.2010.08.022  1
2011 Mohseny AB, Xiao W, Carvalho R, Spaink HP, Hogendoorn PC, Cleton-Jansen A. Abstract 4295: High-throughput screening of osteosarcoma progression: A zebrafish model Cancer Research. 71: 4295-4295. DOI: 10.1158/1538-7445.Am2011-4295  1
2011 Peng K, Tomatsu I, Broek Bvd, Cui C, Korobko AV, Noort Jv, Meijer AH, Spaink HP, Kros A. Dextran based photodegradable hydrogels formed via a Michael addition Soft Matter. 7: 4881-4887. DOI: 10.1039/C1Sm05291H  1
2011 Martens AA, Besseling NAM, Rueb S, Sudhölter EJR, Spaink HP, De Smet LCPM. Random scission of polymers: Numerical simulations, and experiments on hyaluronan hydrolosis Macromolecules. 44: 2559-2567. DOI: 10.1021/Ma200009Y  1
2010 Palstra AP, Tudorache C, Rovira M, Brittijn SA, Burgerhout E, van den Thillart GE, Spaink HP, Planas JV. Establishing zebrafish as a novel exercise model: swimming economy, swimming-enhanced growth and muscle growth marker gene expression. Plos One. 5: e14483. PMID 21217817 DOI: 10.1371/Journal.Pone.0014483  1
2010 Stockhammer OW, Rauwerda H, Wittink FR, Breit TM, Meijer AH, Spaink HP. Transcriptome analysis of Traf6 function in the innate immune response of zebrafish embryos Molecular Immunology. 48: 179-190. PMID 20851470 DOI: 10.1016/J.Molimm.2010.08.011  1
2010 Rauwerda H, Jong Md, Leeuw WCd, Spaink HP, Breit TM. Integrating heterogeneous sequence information for transcriptome-wide microarray design; a Zebrafish example. Bmc Research Notes. 3: 192-192. PMID 20626891 DOI: 10.1186/1756-0500-3-192  1
2010 Kabli S, He S, Spaink HP, Hurlstone A, Jagalska ES, De Groot HJ, Alia A. In vivo magnetic resonance imaging to detect malignant melanoma in adult zebrafish. Zebrafish. 7: 143-8. PMID 20515295 DOI: 10.1089/Zeb.2009.0649  1
2010 Zakrzewska A, Cui C, Stockhammer OW, Benard EL, Spaink HP, Meijer AH. Macrophage-specific gene functions in Spi1-directed innate immunity Blood. 116. PMID 20424185 DOI: 10.1182/Blood-2010-01-262873  1
2010 Palstra AP, Schnabel D, Nieveen MC, Spaink HP, Thillart Gvd. Swimming suppresses hepatic vitellogenesis in European female silver eels as shown by expression of the estrogen receptor 1, vitellogenin1 and vitellogenin2 in the liver Reproductive Biology and Endocrinology. 8: 27-27. PMID 20302623 DOI: 10.1186/1477-7827-8-27  1
2010 Jong Md, Rauwerda H, Bruning O, Verkooijen J, Spaink HP, Breit TM. RNA isolation method for single embryo transcriptome analysis in zebrafish. Bmc Research Notes. 3: 73-73. PMID 20233395 DOI: 10.1186/1756-0500-3-73  1
2010 Akker WMRvd, Durston AJ, Spaink HP. Identification of hoxb1b downstream genes: hoxb1b as a regulatory factor controlling transcriptional networks and cell movement during zebrafish gastrulation The International Journal of Developmental Biology. 54: 55-62. PMID 19876844 DOI: 10.1387/Ijdb.082678Wv  1
2010 Palstra AP, Schnabel D, Nieveen MC, Spaink HP, Thillart GEEJMvd. Temporal expression of hepatic estrogen receptor 1, vitellogenin1 and vitellogenin2 in European silver eels. General and Comparative Endocrinology. 166: 1-11. PMID 19766647 DOI: 10.1016/J.Ygcen.2009.09.006  1
2010 Peng K, Cui C, Tomatsu I, Porta F, Meijer AH, Spaink HP, Kros A. Cyclodextrin/dextran based drug carriers for a controlled release of hydrophobic drugs in zebrafish embryos Soft Matter. 6: 3778-3783. DOI: 10.1039/C0Sm00096E  1
2009 Mione M, Meijer AH, Snaar-Jagalska BE, Spaink HP, Trede NS. Disease modeling in zebrafish: cancer and immune responses--a report on a workshop held in Spoleto, Italy, July 20-22, 2009. Zebrafish. 6: 445-51. PMID 20047471 DOI: 10.1089/Zeb.2009.0638  1
2009 Schaaf MJ, Koopmans WJ, Meckel T, van Noort J, Snaar-Jagalska BE, Schmidt TS, Spaink HP. Single-molecule microscopy reveals membrane microdomain organization of cells in a living vertebrate. Biophysical Journal. 97: 1206-14. PMID 19686669 DOI: 10.1016/J.Bpj.2009.05.044  1
2009 Webb KJ, Norton WH, Trümbach D, Meijer AH, Ninkovic J, Topp S, Heck D, Marr C, Wurst W, Theis FJ, Spaink HP, Bally-Cuif L. Zebrafish reward mutants reveal novel transcripts mediating the behavioral effects of amphetamine. Genome Biology. 10: R81. PMID 19646228 DOI: 10.1186/Gb-2009-10-7-R81  1
2009 Hegedus Z, Zakrzewska A, Agoston VC, Ordas A, Rácz P, Mink M, Spaink HP, Meijer AH. Deep sequencing of the zebrafish transcriptome response to mycobacterium infection. Molecular Immunology. 46: 2918-30. PMID 19631987 DOI: 10.1016/J.Molimm.2009.07.002  1
2009 Brittijn SA, Duivesteijn SJ, Belmamoune M, Bertens LF, Bitter W, de Bruijn JD, Champagne DL, Cuppen E, Flik G, Vandenbroucke-Grauls CM, Janssen RA, de Jong IM, de Kloet ER, Kros A, Meijer AH, ... ... Spaink HP, et al. Zebrafish development and regeneration: new tools for biomedical research. The International Journal of Developmental Biology. 53: 835-50. PMID 19557689 DOI: 10.1387/Ijdb.082615Sb  1
2009 van der Sar AM, Spaink HP, Zakrzewska A, Bitter W, Meijer AH. Specificity of the zebrafish host transcriptome response to acute and chronic mycobacterial infection and the role of innate and adaptive immune components. Molecular Immunology. 46: 2317-32. PMID 19409617 DOI: 10.1016/J.Molimm.2009.03.024  1
2009 Stockhammer OW, Zakrzewska A, Hegedûs Z, Spaink HP, Meijer AH. Transcriptome profiling and functional analyses of the zebrafish embryonic innate immune response to Salmonella infection. Journal of Immunology. 182: 5641-5653. PMID 19380811 DOI: 10.4049/Jimmunol.0900082  1
2009 Schaaf MJM, Chatzopoulou A, Spaink HP. The zebrafish as a model system for glucocorticoid receptor research Comparative Biochemistry and Physiology - a Molecular and Integrative Physiology. 153: 75-82. PMID 19168143 DOI: 10.1016/J.Cbpa.2008.12.014  1
2009 Kabli S, Spaink HP, De Groot HJ, Alia A. In vivo metabolite profile of adult zebrafish brain obtained by high-resolution localized magnetic resonance spectroscopy. Journal of Magnetic Resonance Imaging : Jmri. 29: 275-81. PMID 19161175 DOI: 10.1002/Jmri.21609  1
2009 Paulo PMR, Gaiduk A, Kulzer F, Krens SFG, Spaink HP, Schmidt T, Orrit M. Photothermal Correlation Spectroscopy of Gold Nanoparticles in Solution Journal of Physical Chemistry C. 113: 11451-11457. DOI: 10.1021/Jp806875S  1
2009 Harrison MR, Georgiou AS, Lightman EG, Buckle AJ, Spaink HP, Cunliffe VT. Neurodevelopmental functions of the epigenetic machinery in the zebrafish embryo: Histone Deacetylase 1 regulates transformation of neural progenitors into neurons and glia Developmental Biology. 331: 408. DOI: 10.1016/J.Ydbio.2009.05.082  1
2008 Schlaman HR, Schmidt K, Ottenhof D, van Es MH, Oosterkamp TH, Spaink HP. Analysis of interactions of signaling proteins with phage-displayed ligands by fluorescence correlation spectroscopy. Journal of Biomolecular Screening. 13: 766-76. PMID 18753688 DOI: 10.1177/1087057108323124  1
2008 Kulzer F, Laurens N, Besser J, Schmidt T, Orrit M, Spaink HP. Photothermal detection of individual gold nanoparticles: perspectives for high-throughput screening. Chemphyschem : a European Journal of Chemical Physics and Physical Chemistry. 9: 1761-6. PMID 18666264 DOI: 10.1002/Cphc.200800127  1
2008 Palstra AP, Schnabel D, Nieveen MC, Spaink HP, Thillart GEvd. Male silver eels mature by swimming. Bmc Physiology. 8: 14-14. PMID 18616800 DOI: 10.1186/1472-6793-8-14  1
2008 Zhu Y, Hanna RN, Schaaf MJM, Spaink HP, Thomas P. Candidates for membrane progestin receptors-Past approaches and future challenges Comparative Biochemistry and Physiology - C Toxicology and Pharmacology. 148: 381-389. PMID 18602498 DOI: 10.1016/J.Cbpc.2008.05.019  1
2008 Krens SFG, He S, Lamers GEM, Meijer AH, Bakkers J, Schmidt T, Spaink HP, Snaar-Jagalska BE. Distinct functions for ERK1 and ERK2 in cell migration processes during zebrafish gastrulation Developmental Biology. 319: 370-383. PMID 18514184 DOI: 10.1016/J.Ydbio.2008.04.032  1
2008 de Keijzer S, Sergé A, van Hemert F, Lommerse PH, Lamers GE, Spaink HP, Schmidt T, Snaar-Jagalska BE. A spatially restricted increase in receptor mobility is involved in directional sensing during Dictyostelium discoideum chemotaxis. Journal of Cell Science. 121: 1750-7. PMID 18469015 DOI: 10.1242/Jcs.030692  1
2008 Krens SG, Corredor-Adámez M, He S, Snaar-Jagalska BE, Spaink HP. ERK1 and ERK2 MAPK are key regulators of distinct gene sets in zebrafish embryogenesis. Bmc Genomics. 9: 196-196. PMID 18442396 DOI: 10.1186/1471-2164-9-196  1
2008 Schaaf MJ, Champagne D, van Laanen IH, van Wijk DC, Meijer AH, Meijer OC, Spaink HP, Richardson MK. Discovery of a functional glucocorticoid receptor beta-isoform in zebrafish. Endocrinology. 149: 1591-9. PMID 18096659 DOI: 10.1210/En.2007-1364  1
2008 Marques IJ, Leito JT, Spaink HP, Testerink J, Jaspers RT, Witte F, van den Berg S, Bagowski CP. Transcriptome analysis of the response to chronic constant hypoxia in zebrafish hearts. Journal of Comparative Physiology. B, Biochemical, Systemic, and Environmental Physiology. 178: 77-92. PMID 17828398 DOI: 10.1007/S00360-007-0201-4  1
2008 Meijer AH, van der Sar AM, Cunha C, Lamers GE, Laplante MA, Kikuta H, Bitter W, Becker TS, Spaink HP. Identification and real-time imaging of a myc-expressing neutrophil population involved in inflammation and mycobacterial granuloma formation in zebrafish. Developmental and Comparative Immunology. 32: 36-49. PMID 17553562 DOI: 10.1016/J.Dci.2007.04.003  1
2008 Zhu Y, Hanna RN, Harris C, Daly SCJ, Broekhuis J, Schaaf MJM, Spaink HP, Thomas P. The membrane receptors that mediate nongenomic actions of progestin in zebrafish Comparative Biochemistry and Physiology C-Toxicology & Pharmacology. 148: 474-475. DOI: 10.1016/J.Cbpc.2008.10.097  1
2007 Rubio MC, Becana M, Sato S, James EK, Tabata S, Spaink HP. Characterization of genomic clones and expression analysis of the three types of superoxide dismutases during nodule development in Lotus japonicus. Molecular Plant-Microbe Interactions. 20: 262-275. PMID 17378429 DOI: 10.1094/Mpmi-20-3-0262  1
2007 Besser J, Bagowski CP, Salas-Vidal E, Hemert MJv, Bussmann J, Spaink HP. Expression analysis of the family of 14-3-3 proteins in zebrafish development. Gene Expression Patterns. 7: 511-520. PMID 17127101 DOI: 10.1016/J.Modgep.2006.10.007  1
2007 Henkel CV, Bäck T, Kok JN, Rozenberg G, Spaink HP. DNA computing of solutions to knapsack problems. Bio Systems. 88: 156-62. PMID 16860927 DOI: 10.1016/J.Biosystems.2006.06.001  1
2007 Schnabel D, Palstra A, Thillart GVd, Spaink HP. Induced sexual maturation in eel with embryonic zebrafish cell lines that constitutive produce LH and FSH Developmental Biology. 306: 384. DOI: 10.1016/J.Ydbio.2007.03.365  1
2007 Cui C, Salas-Vidal E, Cheng X, Schnabel D, Meijer AH, Spaink HP. Functional analysis of Rac1a signaling in early zebrafish development Developmental Biology. 306: 380. DOI: 10.1016/J.Ydbio.2007.03.352  1
2006 Agalou A, Spaink HP, Roussis A. Novel interaction of selenium-binding protein with glyceraldehyde-3-phosphate dehydrogenase and fructose-bisphosphate aldolase of Arabidopsis thaliana. Functional Plant Biology : Fpb. 33: 847-856. PMID 32689295 DOI: 10.1071/Fp05312  1
2006 Welten MCM, Haan SBd, Boogert Nvd, Noordermeer JN, Lamers GEM, Spaink HP, Meijer AH, Verbeek FJ. ZebraFISH: Fluorescent In Situ Hybridization Protocol and Three-Dimensional Imaging of Gene Expression Patterns Zebrafish. 3: 465-476. PMID 18377226 DOI: 10.1089/Zeb.2006.3.465  1
2006 He S, Salas-Vidal E, Rueb S, Krens SFG, Meijer AH, Snaar-Jagalska BE, Spaink HP. Genetic and transcriptome characterization of model zebrafish cell lines. Zebrafish. 3: 441-453. PMID 18377224 DOI: 10.1089/Zeb.2006.3.441  1
2006 Kabli S, Alia A, Spaink HP, Verbeek FJ, De Groot HJ. Magnetic resonance microscopy of the adult zebrafish. Zebrafish. 3: 431-9. PMID 18377223 DOI: 10.1089/Zeb.2006.3.431  1
2006 Krens SFG, Spaink HP, Snaar-Jagalska BE. Functions of the MAPK family in vertebrate-development. Febs Letters. 580: 4984-4990. PMID 16949582 DOI: 10.1016/J.Febslet.2006.08.025  1
2006 Lommerse PHM, Vastenhoud K, Pirinen NJ, Magee AI, Spaink HP, Schmidt T. Single-molecule diffusion reveals similar mobility for the Lck, H-ras, and K-ras membrane anchors. Biophysical Journal. 91: 1090-1097. PMID 16920696 DOI: 10.1529/Biophysj.105.079053  1
2006 Krens SFG, He S, Spaink HP, Snaar-Jagalska BE. Characterization and expression patterns of the MAPK family in zebrafish. Gene Expression Patterns. 6: 1019-1026. PMID 16774848 DOI: 10.1016/J.Modgep.2006.04.008  1
2006 Rodrigues-Lima F, Dairou J, Diaz CL, Rubio MC, Sim E, Spaink HP, Dupret J. Cloning, functional expression and characterization of Mesorhizobium loti arylamine N‐acetyltransferases: rhizobial symbiosis supplies leguminous plants with the xenobiotic N‐acetylation pathway Molecular Microbiology. 60: 505-512. PMID 16573698 DOI: 10.1111/J.1365-2958.2006.05114.X  1
2006 Schlaman HRM, Olsthoorn MMA, Harteveld M, Dörner L, Djordjevic MA, Thomas-Oates JE, Spaink HP. The production of species-specific highly unsaturated fatty acyl-containing LCOs from Rhizobium leguminosarum bv. trifolii is stringently regulated by nodD and involves the nodRL genes. Molecular Plant-Microbe Interactions. 19: 215-226. PMID 16570652 DOI: 10.1094/Mpmi-19-0215  1
2006 van der Sar AM, Stockhammer OW, van der Laan C, Spaink HP, Bitter W, Meijer AH. MyD88 innate immune function in a zebrafish embryo infection model. Infection and Immunity. 74: 2436-41. PMID 16552074 DOI: 10.1128/Iai.74.4.2436-2441.2006  1
2006 Maraschin SdF, Caspers M, Potokina E, Wülfert F, Graner A, Spaink HP, Wang M. cDNA array analysis of stress-induced gene expression in barley androgenesis Physiologia Plantarum. 127: 535-550. DOI: 10.1111/J.1399-3054.2006.00673.X  1
2006 Henkel CV, Rozenberg G, Spaink HP. Application of Mismatch Detection Methods in DNA Computing Natural Computing. 5: 151-163. DOI: 10.1007/S11047-005-4463-Z  1
2005 Agalou A, Roussis A, Spaink HP. The Arabidopsis selenium-binding protein confers tolerance to toxic levels of selenium. Functional Plant Biology : Fpb. 32: 881-890. PMID 32689184 DOI: 10.1071/Fp05090  1
2005 Corredor-Adámez M, Welten MC, Spaink HP, Jeffery JE, Schoon RT, de Bakker MA, Bagowski CP, Meijer AH, Verbeek FJ, Richardson MK. Genomic annotation and transcriptome analysis of the zebrafish (Danio rerio) hox complex with description of a novel member, hox b 13a. Evolution & Development. 7: 362-75. PMID 16174031 DOI: 10.1111/J.1525-142X.2005.05042.X  1
2005 van der Meer DL, van den Thillart GE, Witte F, de Bakker MA, Besser J, Richardson MK, Spaink HP, Leito JT, Bagowski CP. Gene expression profiling of the long-term adaptive response to hypoxia in the gills of adult zebrafish. American Journal of Physiology. Regulatory, Integrative and Comparative Physiology. 289: R1512-9. PMID 15994372 DOI: 10.1152/Ajpregu.00089.2005  1
2005 Maraschin SF, de Priester W, Spaink HP, Wang M. Androgenic switch: an example of plant embryogenesis from the male gametophyte perspective. Journal of Experimental Botany. 56: 1711-26. PMID 15928015 DOI: 10.1093/Jxb/Eri190  1
2005 Grønlund M, Roussis A, Flemetakis E, Quaedvlieg NEM, Schlaman HRM, Umehara Y, Katinakis P, Stougaard J, Spaink HP. Analysis of Promoter Activity of the Early Nodulin Enod40 in Lotus japonicus Molecular Plant-Microbe Interactions. 18: 414-427. PMID 15915640 DOI: 10.1094/Mpmi-18-0414  1
2005 Salas-Vidal E, Meijer AH, Cheng X, Spaink HP. Genomic annotation and expression analysis of the zebrafish Rho small GTPase family during development and bacterial infection. Genomics. 86: 25-37. PMID 15894457 DOI: 10.1016/J.Ygeno.2005.03.010  1
2005 Lommerse PHM, Snaar-Jagalska BE, Spaink HP, Schmidt T. Single-molecule diffusion measurements of H-Ras at the plasma membrane of live cells reveal microdomain localization upon activation. Journal of Cell Science. 118: 1799-1809. PMID 15860728 DOI: 10.1242/Jcs.02300  1
2005 Meijer AH, Verbeek FJ, Salas-Vidal E, Corredor-Adámez M, Bussman J, van der Sar AM, Otto GW, Geisler R, Spaink HP. Transcriptome profiling of adult zebrafish at the late stage of chronic tuberculosis due to Mycobacterium marinum infection. Molecular Immunology. 42: 1185-203. PMID 15829308 DOI: 10.1016/J.Molimm.2004.11.014  1
2005 Maraschin Sde F, Gaussand G, Pulido A, Olmedilla A, Lamers GE, Korthout H, Spaink HP, Wang M. Programmed cell death during the transition from multicellular structures to globular embryos in barley androgenesis. Planta. 221: 459-70. PMID 15645302 DOI: 10.1007/S00425-004-1460-X  1
2005 Maraschin SdF, Vennik M, Lamers GEM, Spaink HP, Wang M. Time-lapse tracking of barley androgenesis reveals position-determined cell death within pro-embryos Planta. 220: 531-540. PMID 15449059 DOI: 10.1007/S00425-004-1371-X  1
2005 Henkel CV, Bladergroen RS, Balog CI, Deelder AM, Head T, Rozenberg G, Spaink HP. Protein output for DNA computing Natural Computing. 4: 1-10. DOI: 10.1007/S11047-004-5199-X  1
2004 Kuijt SJ, Lamers GE, Rueb S, Scarpella E, Ouwerkerk PB, Spaink HP, Meijer AH. Different subcellular localization and trafficking properties of KNOX class 1 homeodomain proteins from rice. Plant Molecular Biology. 55: 781-96. PMID 15604716 DOI: 10.1007/S11103-004-1967-3  1
2004 Schmidt KA, Henkel CV, Rozenberg G, Spaink HP. DNA computing using single-molecule hybridization detection. Nucleic Acids Research. 32: 4962-8. PMID 15388798 DOI: 10.1093/Nar/Gkh817  1
2004 Lommerse PHM, Spaink HP, Schmidt T. In vivo plasma membrane organization: results of biophysical approaches. Biochimica Et Biophysica Acta. 1664: 119-131. PMID 15328044 DOI: 10.1016/J.Bbamem.2004.05.005  1
2004 Spaink HP. Specific recognition of bacteria by plant LysM domain receptor kinases. Trends in Microbiology. 12: 201-204. PMID 15120137 DOI: 10.1016/J.Tim.2004.03.001  0.01
2004 Hemert MJv, Niemantsverdriet M, Schmidt T, Backendorf C, Spaink HP. Isoform-specific differences in rapid nucleocytoplasmic shuttling cause distinct subcellular distributions of 14-3-3σ and 14-3-3ζ Journal of Cell Science. 117: 1411-1420. PMID 14996909 DOI: 10.1242/Jcs.00990  1
2004 Bakkers J, Kramer C, Pothof J, Quaedvlieg NE, Spaink HP, Hammerschmidt M. Has2 is required upstream of Rac1 to govern dorsal migration of lateral cells during zebrafish gastrulation. Development (Cambridge, England). 131: 525-37. PMID 14729574 DOI: 10.1242/Dev.00954  1
2004 Lommerse PH, Blab GA, Cognet L, Harms GS, Snaar-Jagalska BE, Spaink HP, Schmidt T. Single-molecule imaging of the H-ras membrane-anchor reveals domains in the cytoplasmic leaflet of the cell membrane. Biophysical Journal. 86: 609-16. PMID 14695305 DOI: 10.1016/S0006-3495(04)74139-9  1
2004 Meijer AH, Krens SFG, Rodriguez IAM, He S, Bitter W, Snaar-Jagalska BE, Spaink HP. Expression analysis of the Toll-like receptor and TIR domain adaptor families of zebrafish. Molecular Immunology. 40: 773-783. PMID 14687934 DOI: 10.1016/J.Molimm.2003.10.003  1
2003 Noreen S, Schlaman HRM, Bellogín RA, Buendía-Clavería AM, Espuny M, Harteveld M, Medina C, Ollero FJ, Olsthoorn MA, Soria-Diaz ME, Spaink HP, Temprano F, Thomas-Oates J, Vinardell JM, Yang SS, et al. Alfalfa nodulation by Sinorhizobium fredii does not require sulfated Nod-factors. Functional Plant Biology : Fpb. 30: 1219-1232. PMID 32689103 DOI: 10.1071/Fp03093  1
2003 Pacios-Bras C, Schlaman HRM, Boot K, Admiraal P, Langerak JM, Stougaard J, Spaink HP. Auxin distribution in Lotus japonicus during root nodule development. Plant Molecular Biology. 52: 1169-1180. PMID 14682616 DOI: 10.1023/B:Plan.0000004308.78057.F5  1
2003 Thomas-Oates J, Bereszczak J, Edwards E, Gill A, Noreen S, Zhou JC, Chen MZ, Miao LH, Xie FL, Yang JK, Zhou Q, Yang SS, Li XH, Wang L, Spaink HP, et al. A catalogue of molecular, physiological and symbiotic properties of soybean-nodulating rhizobial strains from different soybean cropping areas of China. Systematic and Applied Microbiology. 26: 453-65. PMID 14529189 DOI: 10.1078/072320203322497491  1
2003 Girard G, Roussis A, Gultyaev AP, Pleij CWA, Spaink HP. Structural motifs in the RNA encoded by the early nodulation gene enod40 of soybean. Nucleic Acids Research. 31: 5003-5015. PMID 12930950 DOI: 10.1093/Nar/Gkg721  1
2003 Snaar-Jagalska BE, Krens SF, Robina I, Wang LX, Spaink HP. Specific activation of ERK pathways by chitin oligosaccharides in embryonic zebrafish cell lines. Glycobiology. 13: 725-32. PMID 12881410 DOI: 10.1093/Glycob/Cwg103  1
2003 Maraschin SdF, Lamers GEM, Pater BSd, Spaink HP, Wang M. 14‐3‐3 isoforms and pattern formation during barley microspore embryogenesis Journal of Experimental Botany. 54: 1033-1043. PMID 12598573 DOI: 10.1093/Jxb/Erg098  1
2003 Bladergroen MR, Badelt K, Spaink HP. Infection-Blocking Genes of a Symbiotic Rhizobium leguminosarum Strain That Are Involved in Temperature-Dependent Protein Secretion Molecular Plant-Microbe Interactions. 16: 53-64. PMID 12580282 DOI: 10.1094/Mpmi.2003.16.1.53  1
2003 Vinuesa P, Neumann-Silkow F, Pacios-Bras C, Spaink HP, Martínez-Romero E, Werner D. Genetic analysis of a pH-regulated operon from Rhizobium tropici CIAT899 involved in acid tolerance and nodulation competitiveness. Molecular Plant-Microbe Interactions. 16: 159-168. PMID 12575750 DOI: 10.1094/Mpmi.2003.16.2.159  1
2003 Verbeek FJ, Rodrigues DD, Spaink H, Siebes A. Data submission of 3D image sets to a bio-molecular database using active shape models and a 3D reference model for projection Electronic Imaging. 5304: 13-23. DOI: 10.1117/12.527049  1
2003 Rozenberg G, Spaink H. DNA computing by blocking Theoretical Computer Science. 292: 653-665. DOI: 10.1016/S0304-3975(01)00194-3  1
2002 Pacios-Bras C, Burgt YEMvd, Deelder AM, Vinuesa P, Werner D, Spaink HP. Novel lipochitin oligosaccharide structures produced by Rhizobium etli KIM5s. Carbohydrate Research. 337: 1193-1202. PMID 12110194 DOI: 10.1016/S0008-6215(02)00111-8  1
2002 Spaink HP. Plant-microbe interactions: a receptor in symbiotic dialogue. Nature. 417: 910-911. PMID 12087390 DOI: 10.1038/417910A  0.01
2002 Flemetakis E, Agalou A, Kavroulakis N, Dimou M, Martsikovskaya A, Slater A, Spaink HP, Roussis A, Katinakis P. Lotus japonicus gene Ljsbp is highly conserved among plants and animals and encodes a homologue to the mammalian selenium-binding proteins. Molecular Plant-Microbe Interactions. 15: 313-322. PMID 12026169 DOI: 10.1094/Mpmi.2002.15.4.313  1
2002 Robina I, Gómez-Bujedo S, Fernández-Bolaños JG, Fuentes J, Spaink HP. Synthesis and biological evaluation of oligosaccharides related to the molecule signals in plant defence and the Rhizobium-legume symbiosis Tetrahedron. 58: 521-530. DOI: 10.1016/S0040-4020(01)01148-6  1
2001 Holst PPGvd, Schlaman HRM, Spaink HP. Proteins involved in the production and perception of oligosaccharides in relation to plant and animal development Current Opinion in Structural Biology. 11: 608-616. PMID 11785763 DOI: 10.1016/S0959-440X(00)00255-4  1
2001 Harms GS, Cognet L, Lommerse PHM, Blab GA, Kahr H, Gamsjäger R, Spaink HP, Soldatov NM, Romanin C, Schmidt T. Single-Molecule Imaging of L-Type Ca2+ Channels in Live Cells Biophysical Journal. 81: 2639-2646. PMID 11606277 DOI: 10.1016/S0006-3495(01)75907-3  1
2001 Yang SS, Bellogín RA, Buendía A, Camacho M, Chen M, Cubo T, Daza A, Díaz CL, Espuny MR, Gutiérrez R, Harteveld M, Li XH, Lyra MC, Madinabeitia N, Medina C, ... ... Spaink HP, et al. Effect of pH and soybean cultivars on the quantitative analyses of soybean rhizobia populations. Journal of Biotechnology. 91: 243-55. PMID 11566395 DOI: 10.1016/S0168-1656(01)00340-6  1
2001 Spronsen PCv, Grønlund M, Bras CP, Spaink HP, Kijne JW. Cell biological changes of outer cortical root cells in early determinate nodulation. Molecular Plant-Microbe Interactions. 14: 839-847. PMID 11437257 DOI: 10.1094/Mpmi.2001.14.7.839  1
2001 López-Lara IM, Kafetzopoulos D, Spaink HP, Thomas-Oates JE. Rhizobial NodL O-Acetyl Transferase and NodS N-Methyl Transferase Functionally Interfere in Production of Modified Nod Factors Journal of Bacteriology. 183: 3408-3416. PMID 11344149 DOI: 10.1128/Jb.183.11.3408-3416.2001  1
2001 Okker RJ, Spaink HP, Lugtenberg BJ, Schlaman HR. Mutants in the nodFEL promoter of Rhizobium leguminosarum bv. viciae reveal a role of individual nucleotides in transcriptional activation and protein binding. Archives of Microbiology. 175: 152-60. PMID 11285743 DOI: 10.1007/S002030000249  1
2000 Stuurman N, Bras CP, Schlaman HRM, Wijfjes AHM, Bloemberg G, Spaink HP. Use of green fluorescent protein color variants expressed on stable broad-host-range vectors to visualize rhizobia interacting with plants. Molecular Plant-Microbe Interactions. 13: 1163-1169. PMID 11059482 DOI: 10.1094/Mpmi.2000.13.11.1163  1
2000 Spaink HP. Root Nodulation And Infection Factors Produced By Rhizobial Bacteria Annual Review of Microbiology. 54: 257-288. PMID 11018130 DOI: 10.1146/Annurev.Micro.54.1.257  0.01
2000 Kamst E, Breek CKD, Spaink HP. Functional analysis of chimeras derived from the Sinorhizobium meliloti and Mesorhizobium loti nodC genes identifies regions controlling chitin oligosaccharide chain length. Molecular Genetics and Genomics. 264: 75-81. PMID 11016835 DOI: 10.1007/S004380000281  1
2000 Head T, Rozenberg G, Bladergroen RS, Breek CKD, Lommerse PHM, Spaink HP. Computing with DNA by operating on plasmids Biosystems. 57: 87-93. PMID 11004388 DOI: 10.1016/S0303-2647(00)00091-5  1
2000 Flemetakis E, Kavroulakis N, Quaedvlieg NEM, Spaink HP, Dimou M, Roussis A, Katinakis P. Lotus japonicus contains two distinct ENOD40 genes that are expressed in symbiotic, nonsymbiotic, and embryonic tissues. Molecular Plant-Microbe Interactions. 13: 987-994. PMID 10975655 DOI: 10.1094/Mpmi.2000.13.9.987  1
2000 Olsthoorn MMA, Stokvis E, Haverkamp J, Spaink HP, Thomas-Oates JE. Growth temperature regulation of host-specific modifications of rhizobial lipo-chitin oligosaccharides: the function of nodX is temperature regulated. Molecular Plant-Microbe Interactions. 13: 808-820. PMID 10939252 DOI: 10.1094/Mpmi.2000.13.8.808  1
2000 Ovtsyna AO, Schultze M, Tikhonovich IA, Spaink HP, Kondorosi É, Kondorosi Á, Staehelin C. Nod Factors of Rhizobium leguminosarum bv. viciae and Their Fucosylated Derivatives Stimulate a Nod Factor Cleaving Activity in Pea Roots and Are Hydrolyzed In Vitro by Plant Chitinases at Different Rates Molecular Plant-Microbe Interactions. 13: 799-807. PMID 10939251 DOI: 10.1094/Mpmi.2000.13.8.799  1
2000 Bras CP, Jordá MA, Wijfjes AHM, Harteveld M, Stuurman N, Thomas-Oates JE, Spaink HP. A Lotus japonicus Nodulation System Based on Heterologous Expression of the Fucosyl Transferase NodZ and the Acetyl Transferase NolL in Rhizobium leguminosarum Molecular Plant-Microbe Interactions. 13: 475-479. PMID 10755312 DOI: 10.1094/Mpmi.2000.13.4.475  1
2000 Díaz CL, Spaink HP, Kijne JW. Heterologous rhizobial lipochitin oligosaccharides and chitin oligomers induce cortical cell divisions in red clover roots, transformed with the pea lectin gene. Molecular Plant-Microbe Interactions. 13: 268-276. PMID 10707352 DOI: 10.1094/Mpmi.2000.13.3.268  1
1999 Spaink HP. Knocking out nodules Nature. 402: 135-136. PMID 10647002 DOI: 10.1038/45952  0.01
1999 Boone CM, Olsthoorn MMA, Dakora FD, Spaink HP, Thomas-Oates JE. Structural characterisation of lipo-chitin oligosaccharides isolated from Bradyrhizobium aspalati, microsymbionts of commercially important South African legumes Carbohydrate Research. 317: 155-163. PMID 10466212 DOI: 10.1016/S0008-6215(99)00083-X  1
1999 Kamst E, Bakkers J, Quaedvlieg NE, Pilling J, Kijne JW, Lugtenberg BJ, Spaink HP. Chitin oligosaccharide synthesis by rhizobia and zebrafish embryos starts by glycosyl transfer to O4 of the reducing-terminal residue. Biochemistry. 38: 4045-52. PMID 10194317 DOI: 10.1021/Bi982531U  1
1999 Ovtsyna AO, Rademaker GJ, Esser E, Weinman J, Rolfe BG, Tikhonovich IA, Lugtenberg BJ, Thomas-Oates JE, Spaink HP. Comparison of characteristics of the nodX genes from various Rhizobium leguminosarum strains. Molecular Plant-Microbe Interactions : Mpmi. 12: 252-8. PMID 10065561 DOI: 10.1094/Mpmi.1999.12.3.252  1
1999 Lamrabet Y, Bellogín RA, Cubo T, Espuny R, Gil A, Krishnan HB, Megias M, Ollero FJ, Pueppke SG, Ruiz-Sainz JE, Spaink HP, Tejero-Mateo P, Thomas-Oates J, Vinardell JM. Mutation in GDP-fucose synthesis genes of Sinorhizobium fredii alters Nod factors and significantly decreases competitiveness to nodulate soybeans. Molecular Plant-Microbe Interactions. 12: 207-217. PMID 10065558 DOI: 10.1094/Mpmi.1999.12.3.207  1
1999 Boot KJM, Brussel AANv, Tak T, Spaink HP, Kijne JW. Lipochitin Oligosaccharides from Rhizobium leguminosarum bv. viciae Reduce Auxin Transport Capacity in Vicia sativa subsp. nigra Roots Molecular Plant-Microbe Interactions. 12: 839-844. DOI: 10.1094/Mpmi.1999.12.10.839  1
1999 Kamst E, Zegelaar-Jaarsveld K, Van Der Marel GA, Van Boom JH, Lugtenberg BJJ, Spaink HP. Chemical synthesis of N-acetylglucosamine derivatives and their use as glycosyl acceptors by the Mesorhizobium loti chitin oligosaccharide synthase NodC Carbohydrate Research. 321: 176-189. DOI: 10.1016/S0008-6215(99)00190-1  1
1998 Mathesius U, Schlaman HRM, Spaink HP, Rolfe BG, Djordjevic MA. Auxin transport inhibition precedes root nodule formation in white clover roots and is regulated by flavonoids and derivatives of chitin oligosaccharides. Plant Journal. 14: 23-34. PMID 15494052 DOI: 10.1046/J.1365-313X.1998.00090.X  1
1998 Bladergroen MR, Spaink HP. Genes and signal molecules involved in the rhizobiaLeguminoseae symbiosis Current Opinion in Plant Biology. 1: 353-359. PMID 10066605 DOI: 10.1016/1369-5266(88)80059-1  1
1998 Quaedvlieg NEM, Schlaman HRM, Admiraal PC, Wijting SE, Stougaard J, Spaink HP. Fusions between green fluorescent protein and beta-glucuronidase as sensitive and vital bifunctional reporters in plants. Plant Molecular Biology. 38: 861-873. PMID 9862502 DOI: 10.1023/A:1006182623165  1
1998 Olsthoorn MMA, López-Lara IM, Petersen BO, Bock K, Haverkamp J, Spaink HP, Thomas-Oates JE. Novel branched nod factor structure results from α-(1→3) fucosyl transferase activity: The major lipo-chitin oligosaccharides from Mesorhizobium loti strain NZP2213 bear an α-(1→3) fucosyl substituent on a nonterminal backbone residue Biochemistry. 37: 9024-9032. PMID 9636046 DOI: 10.1021/Bi972937R  1
1998 Ritsema T, Gehring AM, Stuitje AR, van der Drift KM, Dandal I, Lambalot RH, Walsh CT, Thomas-Oates JE, Lugtenberg BJ, Spaink HP. Functional analysis of an interspecies chimera of acyl carrier proteins indicates a specialized domain for protein recognition. Molecular & General Genetics : Mgg. 257: 641-8. PMID 9604887 DOI: 10.1007/S004380050692  1
1998 Semino CE, Allende ML, Bakkers J, Spaink HP, Robbins PP. Expression of Rhizobium chitin oligosaccharide fucosyltransferase in zebrafish embryos disrupts normal development. Annals of the New York Academy of Sciences. 842: 49-54. PMID 9599293 DOI: 10.1111/J.1749-6632.1998.Tb09631.X  1
1998 Kamst E, Spaink HP, Kafetzopoulos D. Biosynthesis and secretion of rhizobial lipochitin-oligosaccharide signal molecules. Sub-Cellular Biochemistry. 29: 29-71. PMID 9594644 DOI: 10.1007/978-1-4899-1707-2_2  1
1998 Dekkers LC, Bloemendaal CJ, de Weger LA, Wijffelman CA, Spaink HP, Lugtenberg BJ. A two-component system plays an important role in the root-colonizing ability of Pseudomonas fluorescens strain WCS365. Molecular Plant-Microbe Interactions : Mpmi. 11: 45-56. PMID 9425686 DOI: 10.1094/Mpmi.1998.11.1.45  1
1998 Geiger O, Glushka J, Lugtenberg BJ, Spaink HP, Thomas-Oates JE. NodFE-dependent fatty acids that lack an alpha-beta unsaturation are subject to differential transfer, leading to novel phospholipids. Molecular Plant-Microbe Interactions : Mpmi. 11: 33-44. PMID 9425685 DOI: 10.1094/Mpmi.1998.11.1.33  1
1998 Ovtsyna AO, Geurts R, Bisseling T, Lugtenberg BJJ, Tikhonovich IA, Spaink HP. Restriction of host range by the sym2 allele of Afghan pea is nonspecific for the type of modification at the reducing terminus of nodulation signals Molecular Plant-Microbe Interactions. 11: 418-422. DOI: 10.1094/Mpmi.1998.11.5.418  1
1998 Mathesius U, Bayliss C, Weinman JJ, Schlaman HRM, Spaink HP, Rolfe BG, McCully ME, Djordjevic MA. Flavonoids Synthesized in Cortical Cells During Nodule Initiation Are Early Developmental Markers in White Clover Molecular Plant-Microbe Interactions. 11: 1223-1232. DOI: 10.1094/Mpmi.1998.11.12.1223  1
1997 Gil-Serrano AM, Franco-Rodríguez G, Tejero-Mateo P, Thomas-Oates J, Spaink HP, Ruiz-Sainz J, Megías M, Lamrabet Y. Structural determination of the lipo-chitin oligosaccharide nodulation signals produced by Rhizobium fredii HH103. Carbohydrate Research. 303: 435-443. PMID 9403989 DOI: 10.1016/S0008-6215(97)00189-4  1
1997 Roest HP, Mulders IH, Spaink HP, Wijffelman CA, Lugtenberg BJ. A Rhizobium leguminosarum biovar trifolii locus not localized on the sym plasmid hinders effective nodulation on plants of the pea cross-inoculation group. Molecular Plant-Microbe Interactions : Mpmi. 10: 938-41. PMID 9304865 DOI: 10.1094/Mpmi.1997.10.7.938  1
1997 Bakkers J, Semino CE, Stroband H, Kijne JW, Robbins PW, Spaink HP. An important developmental role for oligosaccharides during early embryogenesis of cyprinid fish Proceedings of the National Academy of Sciences of the United States of America. 94: 7982-7986. PMID 9223299 DOI: 10.1073/Pnas.94.15.7982  1
1997 Ritsema T, Lugtenberg BJ, Spaink HP. Acyl-acyl carrier protein is a donor of fatty acids in the NodA-dependent step in biosynthesis of lipochitin oligosaccharides by rhizobia. Journal of Bacteriology. 179: 4053-5. PMID 9190826 DOI: 10.1128/Jb.179.12.4053-4055.1997  1
1997 Quinto C, Wijfjes AH, Bloemberg GV, Blok-Tip L, López-Lara IM, Lugtenberg BJ, Thomas-Oates JE, Spaink HP. Bacterial nodulation protein NodZ is a chitin oligosaccharide fucosyltransferase which can also recognize related substrates of animal origin. Proceedings of the National Academy of Sciences of the United States of America. 94: 4336-41. PMID 9113990 DOI: 10.1073/Pnas.94.9.4336  1
1997 Kamst E, Pilling J, Raamsdonk LM, Lugtenberg BJ, Spaink HP. Rhizobium nodulation protein NodC is an important determinant of chitin oligosaccharide chain length in Nod factor biosynthesis. Journal of Bacteriology. 179: 2103-8. PMID 9079892 DOI: 10.1128/Jb.179.7.2103-2108.1997  1
1997 Spaink HP. Ethylene as a regulator of Rhizobium infection Trends in Plant Science. 2: 203-204. DOI: 10.1016/S1360-1385(97)01042-X  0.01
1996 López-Lara IM, Blok-Tip L, Quinto C, Garcia ML, Stacey G, Bloemberg GV, Lamers GE, Lugtenberg BJ, Thomas-Oates JE, Spaink HP. NodZ of Bradyrhizobium extends the nodulation host range of Rhizobium by adding a fucosyl residue to nodulation signals. Molecular Microbiology. 21: 397-408. PMID 8858593 DOI: 10.1046/J.1365-2958.1996.00644.X  1
1996 Folch-Mallol JL, Marroqui S, Sousa C, Manyani H, Lopez-Lara IM, Drift KMGMVD, Haverkamp J, Quinto C, Gil-Serrano A, Thomas-Oates J, Spaink HP, Megias M. Characterization of Rhizobium tropici CIAT899 nodulation factors: the role of nodH and nodPQ genes in their sulfation. Molecular Plant-Microbe Interactions. 9: 151-163. PMID 8850086 DOI: 10.1094/Mpmi-9-0151  1
1996 van der Drift KM, Spaink HP, Bloemberg GV, van Brussel AA, Lugtenberg BJ, Haverkamp J, Thomas-Oates JE. Rhizobium leguminosarum bv. trifolii produces lipo-chitin oligosaccharides with nodE-dependent highly unsaturated fatty acyl moieties. An electrospray ionization and collision-induced dissociation tandem mass spectrometric study. The Journal of Biological Chemistry. 271: 22563-9. PMID 8798424 DOI: 10.1074/Jbc.271.37.22563  1
1996 Ritsema T, Wijfjes AH, Lugtenberg BJ, Spaink HP. Rhizobium nodulation protein NodA is a host-specific determinant of the transfer of fatty acids in Nod factor biosynthesis. Molecular & General Genetics : Mgg. 251: 44-51. PMID 8628246 DOI: 10.1007/Bf02174343  1
1996 Spaink HP. Regulation of plant morphogenesis by lipo-chitin oligosaccharides Critical Reviews in Plant Sciences. 15: 559-582. DOI: 10.1080/07352689609382370  0.01
1995 Spaink HP. The molecular basis of infection and nodulation by rhizobia: the ins and outs of sympathogenesis. Annual Review of Phytopathology. 33: 345-368. PMID 18999965 DOI: 10.1146/Annurev.Py.33.090195.002021  0.01
1995 Bloemberg GV, Kamst E, Harteveld M, van der Drift KM, Haverkamp J, Thomas-Oates JE, Lugtenberg BJ, Spaink HP. A central domain of Rhizobium NodE protein mediates host specificity by determining the hydrophobicity of fatty acyl moieties of nodulation factors. Molecular Microbiology. 16: 1123-36. PMID 8577248 DOI: 10.1111/J.1365-2958.1995.Tb02337.X  1
1995 Smit G, Koster CCd, Schripsema J, Spaink HP, Brussel AAv, Kijne JW. Uridine, a cell division factor in pea roots Plant Molecular Biology. 29: 869-873. PMID 8541512 DOI: 10.1007/Bf00041176  1
1995 López-Lara IM, van der Drift KM, van Brussel AA, Haverkamp J, Lugtenberg BJ, Thomas-Oates JE, Spaink HP. Induction of nodule primordia on Phaseolus and Acacia by lipo-chitin oligosaccharide nodulation signals from broad-host-range Rhizobium strain GRH2. Plant Molecular Biology. 29: 465-77. PMID 8534846 DOI: 10.1007/Bf00020978  1
1995 Cárdenas L, Domínguez J, Quinto C, López-Lara IM, Lugtenberg BJ, Spaink HP, Rademaker GJ, Haverkamp J, Thomas-Oates JE. Isolation, chemical structures and biological activity of the lipo-chitin oligosaccharide nodulation signals from Rhizobium etli. Plant Molecular Biology. 29: 453-64. PMID 8534845 DOI: 10.1007/Bf00020977  1
1995 López-Lara IM, van den Berg JD, Thomas-Oates JE, Glushka J, Lugtenberg BJ, Spaink HP. Structural identification of the lipo-chitin oligosaccharide nodulation signals of Rhizobium loti. Molecular Microbiology. 15: 627-38. PMID 7783635 DOI: 10.1111/J.1365-2958.1995.Tb02372.X  1
1995 Kamst E, van der Drift KM, Thomas-Oates JE, Lugtenberg BJ, Spaink HP. Mass spectrometric analysis of chitin oligosaccharides produced by Rhizobium NodC protein in Escherichia coli. Journal of Bacteriology. 177: 6282-5. PMID 7592395 DOI: 10.1128/Jb.177.21.6282-6285.1995  1
1995 Spaink HP, Wijfjes AH, Lugtenberg BJ. Rhizobium NodI and NodJ proteins play a role in the efficiency of secretion of lipochitin oligosaccharides. Journal of Bacteriology. 177: 6276-81. PMID 7592394 DOI: 10.1128/Jb.177.21.6276-6281.1995  1
1995 Bloemberg GV, Lagas RM, van Leeuwen S, Van der Marel GA, Van Boom JH, Lugtenberg BJ, Spaink HP. Substrate specificity and kinetic studies of nodulation protein NodL of Rhizobium leguminosarum. Biochemistry. 34: 12712-20. PMID 7548024 DOI: 10.1021/Bi00039A030  1
1995 Diaz CL, Spaink HP, Wijffelman CA, Kijne JW. Genomic requirements of Rhizobium for nodulation of white clover hairy roots transformed with the pea lectin gene Molecular Plant-Microbe Interactions. 8: 348-356. DOI: 10.1094/Mpmi-8-0348  1
1994 Heidstra R, Geurts R, Franssen H, Spaink HP, Van Kammen A, Bisseling T. Root Hair Deformation Activity of Nodulation Factors and Their Fate on Vicia sativa. Plant Physiology. 105: 787-797. PMID 12232242 DOI: 10.1104/Pp.105.3.787  1
1994 Bloemberg GV, Thomas-Oates JE, Lugtenberg BJ, Spaink HP. Nodulation protein NodL of Rhizobium leguminosarum O-acetylates lipo-oligosaccharides, chitin fragments and N-acetylglucosamine in vitro. Molecular Microbiology. 11: 793-804. PMID 8196551 DOI: 10.1111/J.1365-2958.1994.Tb00357.X  1
1994 Ritsema T, Geiger O, van Dillewijn P, Lugtenberg BJ, Spaink HP. Serine residue 45 of nodulation protein NodF from Rhizobium leguminosarum bv. viciae is essential for its biological function. Journal of Bacteriology. 176: 7740-3. PMID 8002602 DOI: 10.1128/Jb.176.24.7740-7743.1994  1
1994 Spaink HP, Lugtenberg BJ. Role of rhizobial lipo-chitin oligosaccharide signal molecules in root nodule organogenesis. Plant Molecular Biology. 26: 1413-22. PMID 7858197 DOI: 10.1007/Bf00016482  1
1994 Spaink HP, Wijfjes AH, van der Drift KM, Haverkamp J, Thomas-Oates JE, Lugtenberg BJ. Structural identification of metabolites produced by the NodB and NodC proteins of Rhizobium leguminosarum. Molecular Microbiology. 13: 821-31. PMID 7815941 DOI: 10.1111/J.1365-2958.1994.Tb00474.X  1
1994 Spaink HP. The molecular basis of the host specificity of the Rhizobium bacteria. Antonie Van Leeuwenhoek International Journal of General and Molecular Microbiology. 65: 81-98. PMID 7718036 DOI: 10.1007/Bf00871750  0.01
1994 Maagd RAD, Yang W, Roo LG, Mulders IHM, Roest HP, Spaink HP, Bisseling T, Lugtenberg BJJ. Down-regulation of expression of the Rhizobium leguminosarum outer membrane protein gene ropA occurs abruptly in interzone II-III of pea nodules and can be uncoupled from nif gene activation. Molecular Plant-Microbe Interactions. 7: 276-281. DOI: 10.1094/Mpmi-7-0276  1
1994 Geiger O, Ritsema T, Brussel AANv, Tak T, Wijfjes AHM, Bloemberg GV, Spaink HP, Lugtenberg BJJ. Role of rhizobial lipo-oligosacharides in root nodule formation on leguminous plants Plant and Soil. 161: 81-89. DOI: 10.1007/978-94-011-1088-4_8  1
1993 De Jong AJ, Heidstra R, Spaink HP, Hartog MV, Meijer EA, Hendriks T, Schiavo FL, Terzi M, Bisseling T, Van Kammen A, De Vries SC. Rhizobium Lipooligosaccharides Rescue a Carrot Somatic Embryo Mutant. The Plant Cell. 5: 615-620. PMID 12271077 DOI: 10.1105/Tpc.5.6.615  1
1993 Horvath B, Heidstra R, Lados M, Moerman M, Spaink HP, Promé JC, Van Kammen A, Bisseling T. Lipo-oligosaccharides of Rhizobium induce infection-related early nodulin gene expression in pea root hairs Plant Journal. 4: 727-733. PMID 8252073 DOI: 10.1046/J.1365-313X.1993.04040727.X  1
1993 Spaink H, Wijfjes A, van VT, Kijne J, Lugtenberg B. Rhizobial Lipo-oligosaccharide Signals and Their Role in Plant Morphogenesis; Are Analogous Lipophilic Chitin Derivatives Produced by the Plant? Australian Journal of Plant Physiology. 20: 381-392. DOI: 10.1071/Pp9930381  1
1992 van Brussel AA, Bakhuizen R, van Spronsen PC, Spaink HP, Tak T, Lugtenberg BJ, Kijne JW. Induction of pre-infection thread structures in the leguminous host plant by mitogenic lipo-oligosaccharides of Rhizobium. Science (New York, N.Y.). 257: 70-2. PMID 17800714 DOI: 10.1126/Science.257.5066.70  1
1992 Spaink HP, Aarts A, Stacey G, Bloemberg GV, Lugtenberg BJ, Kennedy EP. Detection and separation of Rhizobium and Bradyrhizobium Nod metabolites using thin-layer chromatography. Molecular Plant-Microbe Interactions : Mpmi. 5: 72-80. PMID 1600238 DOI: 10.1094/Mpmi-5-072  1
1992 Sanjuan J, Carlson RW, Spaink HP, Bhat UR, Barbour WM, Glushka J, Stacey G. A 2-O-methylfucose moiety is present in the lipo-oligosaccharide nodulation signal of Bradyrhizobium japonicum Proceedings of the National Academy of Sciences of the United States of America. 89: 8789-8793. PMID 1528893 DOI: 10.1073/Pnas.89.18.8789  1
1992 Spaink HP. Rhizobial lipo-oligosaccharides: answers and questions. Plant Molecular Biology. 20: 977-986. PMID 1463833 DOI: 10.1007/Bf00027167  0.01
1991 Geiger O, Spaink HP, Kennedy EP. Isolation of the Rhizobium leguminosarum NodF nodulation protein: NodF carries a 4'-phosphopantetheine prosthetic group. Journal of Bacteriology. 173: 2872-8. PMID 2019559 DOI: 10.1128/Jb.173.9.2872-2878.1991  1
1991 Spaink HP, Sheeley DM, van Brussel AA, Glushka J, York WS, Tak T, Geiger O, Kennedy EP, Reinhold VN, Lugtenberg BJ. A novel highly unsaturated fatty acid moiety of lipo-oligosaccharide signals determines host specificity of Rhizobium. Nature. 354: 125-30. PMID 1944592 DOI: 10.1038/354125A0  1
1990 Brussel AANv, Recourt K, Pees E, Spaink HP, Tak T, Wijffelman CA, Kijne JW, Lugtenberg BJJ. A biovar-specific signal of Rhizobium leguminosarum bv. viciae induces increased nodulation gene-inducing activity in root exudate of Vicia sativa subsp. nigra. Journal of Bacteriology. 172: 5394-5401. PMID 2394688 DOI: 10.1128/Jb.172.9.5394-5401.1990  1
1990 Scheres B, Van De Wiel C, Zalensky A, Horvath B, Spaink H, Van Eck H, Zwartkruis F, Wolters AM, Gloudemans T, Van Kammen A. The ENOD12 gene product is involved in the infection process during the pea-Rhizobium interaction. Cell. 60: 281-94. PMID 2297789 DOI: 10.1016/0092-8674(90)90743-X  1
1989 Spaink HP, Wijffelman CA, Okker RJH, Lugtenberg BEJ. Localization of functional regions of the Rhizobium nodD product using hybrid nodD genes. Plant Molecular Biology. 12: 59-73. PMID 24272718 DOI: 10.1007/Bf00017448  1
1989 Maagd BAD, Wijfjes AHM, Spaink HP, Ruiz-Sainz JE, Wijffelman CA, Okker RJH, Lugtenberg BJJ. nodO, a new nod gene of the Rhizobium leguminosarum biovar viciae sym plasmid pRL1JI, encodes a secreted protein. Journal of Bacteriology. 171: 6764-6770. PMID 2687250 DOI: 10.1128/Jb.171.12.6764-6770.1989  1
1989 Schlaman HRM, Spaink HP, Okker RJH, Lugtenberg BJJ. Subcellular localization of the nodD gene product in Rhizobium leguminosarum. Journal of Bacteriology. 171: 4686-4693. PMID 2670892 DOI: 10.1128/Jb.171.9.4686-4693.1989  1
1989 Maagd RAD, Spaink HP, Pees E, Mulders IHM, Wijfjes A, Wijffelman CA, Okker RJH, Lugtenberg BJJ. Localization and symbiotic function of a region on the Rhizobium leguminosarum Sym plasmid pRL1JI responsible for a secreted, flavonoid-inducible 50-kilodalton protein. Journal of Bacteriology. 171: 1151-1157. PMID 2644226 DOI: 10.1128/Jb.171.2.1151-1157.1989  1
1989 Cremers HCJC, Spaink HP, Wijfjes AHM, Pees E, Wijffelman CA, Okker RJH, Lugtenberg BJJ. Additional nodulation genes on the Sym plasmid of Rhizobium leguminosarum biovar viciae. Plant Molecular Biology. 13: 163-174. PMID 2562395 DOI: 10.1007/Bf00016135  1
1989 Spaink HP, Okker RJH, Wijffelman CA, Tak T, Roo LG, Pees E, Brussel AANV, Lugtenberg BJJ. Symbiotic properties of rhizobia containing a flavonoid-independent hybrid nodD product. Journal of Bacteriology. 171: 4045-4053. PMID 2544568 DOI: 10.1128/Jb.171.7.4045-4053.1989  1
1989 Nap JP, van de Wiel C, Spaink HP, Moerman M, van den Heuvel M, Djordjevic MA, van Lammeren AA, van Kammen A, Bisseling T. The relationship between nodulin gene expression and the Rhizobium nod genes in Vicia sativa root nodule development. Molecular Plant-Microbe Interactions : Mpmi. 2: 53-63. PMID 2520161 DOI: 10.1094/Mpmi-2-053  1
1989 Spaink HP, Weinman J, Djordjevic MA, Wijffelman CA, Okker RJH, Lugtenberg BJJ. Genetic analysis and cellular localization of the Rhizobium host specificity-determining NodE protein. The Embo Journal. 8: 2811-2818. DOI: 10.1002/J.1460-2075.1989.Tb08427.X  1
1987 Spaink HP, Okker RJH, Wijffelman CA, Pees E, Lugtenberg BJJ. Promoters in the nodulation region of the Rhizobium leguminosarum Sym plasmid pRL1JI Plant Molecular Biology. 9: 27-39. PMID 24276795 DOI: 10.1007/Bf00017984  1
1987 Zaat SAJ, Wijffelman CA, Spaink HP, Brussel AANV, Okker RJH, Lugtenberg BJJ. Induction of the nodA promoter of Rhizobium leguminosarum Sym plasmid pRL1JI by plant flavanones and flavones. Journal of Bacteriology. 169: 198-204. PMID 3539915 DOI: 10.1128/Jb.169.1.198-204.1987  1
1987 Spaink HP, Wijffelman CA, Pees E, Okker RJH, Lugtenberg BJJ. Rhizobium nodulation gene nodD as a determinant of host specificity Nature. 328: 337-340. DOI: 10.1038/328337A0  1
1986 Backendorf C, Spaink H, Barbeiro AP, van de Putte P. Structure of the uvrB gene of Escherichia coli. Homology with other DNA repair enzymes and characterization of the uvrB5 mutation. Nucleic Acids Research. 14: 2877-90. PMID 3008099 DOI: 10.1093/Nar/14.7.2877  1
1984 Okker RJ, Spaink H, Hille J, van Brussel TA, Lugtenberg B, Schilperoort RA. Plant-inducible virulence promoter of the Agrobacterium tumefaciens Ti plasmid. Nature. 312: 564-6. PMID 6504164 DOI: 10.1038/312564A0  1
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