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Gary L. Stiles - Publications

Affiliations: 
Duke Medical School, Durham, NC, United States 
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76 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2024 Ji XD, von Lubitz D, Olah ME, Stiles GL, Jacobson KA. Species Differences in Ligand Affinity at Central A-Adenosine Receptors. Drug Development Research. 33: 51-59. PMID 38229954 DOI: 10.1002/ddr.430330109  0.624
2019 Fredholm BB, Frenguelli BG, Hills R, IJzerman AP, Jacobson KA, Klotz K, Linden J, Müller CE, Schwabe U, Stiles GL. Adenosine receptors (version 2019.4) in the IUPHAR/BPS Guide to Pharmacology Database Iuphar/Bps Guide to Pharmacology Cite. 2019. DOI: 10.2218/gtopdb/f3/2019.4  0.681
2012 Ji XD, Stiles GL, Jacobson KA. [(3)H]XAC (xanthine amine congener) is a radioligand for A(2)-adenosine receptors in rabbit striatum. Neurochemistry International. 18: 207-13. PMID 20504695 DOI: 10.1016/0197-0186(91)90187-I  0.689
2010 KARTON Y, JIANG J, JI X, MELMAN N, OLAH ME, STILES GL, JACOBSON KA. ChemInform Abstract: Synthesis and Biological Activities of Flavonoid Derivatives as A3 Adenosine Receptor Antagonists. Cheminform. 27: no-no. DOI: 10.1002/CHIN.199638149  0.635
2010 BARALDI PG, CACCIARI B, SPALLUTO G, JI X, OLAH ME, STILES G, DIONISOTTI S, ZOCCHI C, ONGINI E, JACOBSON KA. ChemInform Abstract: Novel N6-(Substituted-phenylcarbamoyl)adenosine-5′-uronamides as Potent Agonists for A3 Adenosine Receptors. Cheminform. 27: no-no. DOI: 10.1002/CHIN.199621237  0.645
2000 Olah ME, Stiles GL. The role of receptor structure in determining adenosine receptor activity. Pharmacology & Therapeutics. 85: 55-75. PMID 10722120 DOI: 10.1016/S0163-7258(99)00051-0  0.582
2000 Palmer TM, Stiles GL. Identification of Threonine Residues Controlling the Agonist-Dependent Phosphorylation and Desensitization of the Rat A3 Adenosine Receptor Molecular Pharmacology. 57: 539-545. DOI: 10.1124/Mol.57.3.539  0.491
1999 Palmer TM, Stiles GL. Stimulation of A(2A) adenosine receptor phosphorylation by protein kinase C activation: evidence for regulation by multiple protein kinase C isoforms. Biochemistry. 38: 14833-42. PMID 10555965 DOI: 10.1021/Bi990825P  0.524
1999 Xie R, Li AH, Ji XD, Melman N, Olah ME, Stiles GL, Jacobson KA. Selective A(3) adenosine receptor antagonists: water-soluble 3, 5-diacyl-1,2,4-trialkylpyridinium salts and their oxidative generation from dihydropyridine precursors. Journal of Medicinal Chemistry. 42: 4232-8. PMID 10514293 DOI: 10.1021/Jm990234X  0.687
1999 Ren H, Stiles GL. Dexamethasone stimulates human A1 adenosine receptor (A1AR) gene expression through multiple regulatory sites in promoter B. Molecular Pharmacology. 55: 309-16. PMID 9927623 DOI: 10.1124/Mol.55.2.309  0.427
1998 Deckert J, Nöthen MM, Albus M, Franzek E, Rietschel M, Ren H, Stiles GL, Knapp M, Weigelt B, Maier W, Beckmann H, Propping P. Adenosine A1 receptor and bipolar affective disorder: systematic screening of the gene and association studies. American Journal of Medical Genetics. 81: 18-23. PMID 9514582 DOI: 10.1002/(Sici)1096-8628(19980207)81:1<18::Aid-Ajmg4>3.0.Co;2-J  0.314
1998 Ren H, Stiles GL. A single-stranded DNA binding site in the human A1 adenosine receptor gene promoter. Molecular Pharmacology. 53: 43-51. PMID 9443931 DOI: 10.1124/Mol.53.1.43  0.457
1998 Palmer TM, Stiles GL. Structure-function analysis of inhibitory adenosine receptor regulation. Neuropharmacology. 36: 1141-7. PMID 9364469 DOI: 10.1016/S0028-3908(97)00128-7  0.641
1997 Palmer TM, Harris CA, Coote J, Stiles GL. Induction of multiple effects on adenylyl cyclase regulation by chronic activation of the human A3 adenosine receptor. Molecular Pharmacology. 52: 632-40. PMID 9380026 DOI: 10.1124/Mol.52.4.632  0.524
1997 Jacobson KA, Park KS, Jiang JL, Kim YC, Olah ME, Stiles GL, Ji XD. Pharmacological characterization of novel A3 adenosine receptor-selective antagonists. Neuropharmacology. 36: 1157-65. PMID 9364471 DOI: 10.1016/S0028-3908(97)00104-4  0.695
1997 Olah ME, Stiles GL. Site-directed mutagenesis and chimeric receptors in the study of receptor-ligand binding. Methods in Molecular Biology (Clifton, N.J.). 83: 25-43. PMID 9210134 DOI: 10.1385/0-89603-495-X:25  0.552
1997 Palmer TM, Stiles GL. Identification of an A2a adenosine receptor domain specifically responsible for mediating short-term desensitization. Biochemistry. 36: 832-8. PMID 9020781 DOI: 10.1021/Bi962290V  0.5
1996 Siddiqi SM, Ji XD, Melman N, Olah ME, Jain R, Evans P, Glashofer M, Padgett WL, Cohen LA, Daly JW, Stiles GL, Jacobson KA. A SURVEY OF NONXANTHINE DERIVATIVES AS ADENOSINE RECEPTOR LIGANDS. Nucleosides & Nucleotides. 15: 693-717. PMID 27043138 DOI: 10.1080/07328319608002416  0.702
1996 Stiles GL. Multifunctional G proteins. Searching for functions in the heart. Circulation. 94: 602-3. PMID 8772675 DOI: 10.1161/01.Cir.94.4.602  0.413
1996 van Rhee AM, Jiang JL, Melman N, Olah ME, Stiles GL, Jacobson KA. Interaction of 1,4-dihydropyridine and pyridine derivatives with adenosine receptors: selectivity for A3 receptors. Journal of Medicinal Chemistry. 39: 2980-9. PMID 8709132 DOI: 10.1021/Jm9600205  0.713
1996 Karton Y, Jiang JL, Ji XD, Melman N, Olah ME, Stiles GL, Jacobson KA. Synthesis and biological activities of flavonoid derivatives as A3 adenosine receptor antagonists. Journal of Medicinal Chemistry. 39: 2293-301. PMID 8691424 DOI: 10.1021/Jm950923I  0.704
1996 Palmer TM, Benovic JL, Stiles GL. Molecular basis for subtype-specific desensitization of inhibitory adenosine receptors: Analysis of a chimeric A1-A3 adenosine receptor Journal of Biological Chemistry. 271: 15272-15278. PMID 8663009 DOI: 10.1074/Jbc.271.25.15272  0.705
1996 Baraldi PG, Cacciari B, Spalluto G, Ji XD, Olah ME, Stiles G, Dionisotti S, Zocchi C, Ongini E, Jacobson KA. Novel N6-(substituted-phenylcarbamoyl)adenosine-5'-uronamides as potent agonists for A3 adenosine receptors. Journal of Medicinal Chemistry. 39: 802-6. PMID 8576924 DOI: 10.1021/Jm950518R  0.689
1996 Palmer TM, Stiles GL. Adenosine receptors. Neuropharmacology. 34: 683-94. PMID 8532135 DOI: 10.1016/0028-3908(95)00044-7  0.542
1995 Jacobson KA, Kim HO, Siddiqi SM, Olah ME, Stiles GL, von Lubitz DK. A3-adenosine receptors: design of selective ligands and therapeutic prospects. Drugs of the Future. 20: 689-699. PMID 25242859  0.606
1995 Palmer TM, Stiles GL. The new biology of adenosine receptors. Advances in Enzymology and Related Areas of Molecular Biology. 69: 83-120. PMID 7817871 DOI: 10.1002/9780470123157.Ch3  0.565
1995 Jacobson KA, Siddiqi SM, Olah ME, Ji XD, Melman N, Bellamkonda K, Meshulam Y, Stiles GL, Kim HO. Structure-activity relationships of 9-alkyladenine and ribose-modified adenosine derivatives at rat A3 adenosine receptors Journal of Medicinal Chemistry. 38: 1720-1735. PMID 7752196 DOI: 10.1021/Jm00010A017  0.701
1995 Deckert J, Nöthen MM, Bryant SP, Ren H, Wolf HK, Stiles GL, Spurr NK, Propping P. Human adenosine A1 receptor gene: systematic screening for DNA sequence variation and linkage mapping on chromosome 1q31-32.1 using a silent polymorphism in the coding region. Biochemical and Biophysical Research Communications. 214: 614-21. PMID 7677773 DOI: 10.1006/Bbrc.1995.2330  0.53
1995 Palmer TM, Gettys TW, Stiles GL. Differential interaction with and regulation of multiple G-proteins by the rat A3 adenosine receptor. The Journal of Biological Chemistry. 270: 16895-902. PMID 7622506 DOI: 10.1074/Jbc.270.28.16895  0.404
1995 Olah ME, Stiles GL. Adenosine receptor subtypes: characterization and therapeutic regulation. Annual Review of Pharmacology and Toxicology. 35: 581-606. PMID 7598508 DOI: 10.1146/Annurev.Pa.35.040195.003053  0.574
1995 Palmer TM, Benovic JL, Stiles GL. Agonist-dependent phosphorylation and desensitization of the rat A3 adenosine receptor: Evidence for a G-protein-coupled receptor kinase-mediated mechanism Journal of Biological Chemistry. 270: 29607-29613. PMID 7494005 DOI: 10.1074/Jbc.270.49.29607  0.683
1994 Ren H, Stiles GL. Posttranscriptional mRNA processing as a mechanism for regulation of human A1 adenosine receptor expression. Proceedings of the National Academy of Sciences of the United States of America. 91: 4864-66. PMID 8197148 DOI: 10.1073/Pnas.91.11.4864  0.5
1994 Kim HO, Ji XD, Melman N, Olah ME, Stiles GL, Jacobson KA. Selective ligands for rat A3 adenosine receptors: structure-activity relationships of 1,3-dialkylxanthine 7-riboside derivatives. Journal of Medicinal Chemistry. 37: 4020-30. PMID 7966162 DOI: 10.1021/Jm00049A021  0.695
1994 Kim HO, Ji XD, Siddiqi SM, Olah ME, Stiles GL, Jacobson KA. 2-substitution of n6-benzyladenosine-5′-uronamides enhances selectivity for a3 adenosine receptors Journal of Medicinal Chemistry. 37: 3614-3621. PMID 7932588 DOI: 10.1021/Jm00047A018  0.686
1994 Kim HO, Ji XD, Melman N, Olah ME, Stiles GL, Jacobson KA. Structure-activity relationships of 1,3-dialkylxanthine derivatives at rat A3 adenosine receptors. Journal of Medicinal Chemistry. 37: 3373-82. PMID 7932565 DOI: 10.1021/Jm00046A022  0.684
1994 Ji X, Lubitz DV, Olah ME, Stiles GL, Jacobson KA. Species differences in ligand affinity at central A3-adenosine receptors Drug Development Research. 33: 51-59. DOI: 10.1002/Ddr.430330109  0.703
1993 Jacobson KA, van Galen PJ, Ji XD, Ramkumar V, Olah ME, Stiles GL. Molecular Characterization of A(1) and A(2a) Adenosine Receptors. Drug Development Research. 28: 226-231. PMID 23002320 DOI: 10.1002/Ddr.430280307  0.719
1993 Nanoff C, Stiles GL. Solubilization and characterization of the A2-adenosine receptor. Journal of Receptor Research. 13: 961-73. PMID 8510073 DOI: 10.3109/10799899309073703  0.488
1993 Jacobson KA, Nikodijević O, Shi D, Gallo-Rodriguez C, Olah ME, Stiles GL, Daly JW. A role for central A3-adenosine receptors. Mediation of behavioral depressant effects. Febs Letters. 336: 57-60. PMID 8262217 DOI: 10.1016/0014-5793(93)81608-3  0.662
1992 Jacobson KA, Olah ME, Stiles GL. TRIFUNCTIONAL LIGANDS: A RADIOIODINATED HIGH AFFINITY ACYLATING ANTAGONIST FOR THE A ADENOSINE RECEPTOR. Pharmacology Communications. 1: 145-154. PMID 25374448  0.667
1992 Ji XD, Stiles GL, van Galen PJ, Jacobson KA. Characterization of human striatal A2-adenosine receptors using radioligand binding and photoaffinity labeling. Journal of Receptor Research. 12: 149-69. PMID 1583620 DOI: 10.3109/10799899209074789  0.624
1992 van Galen PJ, Stiles GL, Michaels G, Jacobson KA. Adenosine A1 and A2 receptors: structure--function relationships. Medicinal Research Reviews. 12: 423-71. PMID 1513184 DOI: 10.1002/Med.2610120502  0.693
1992 Olah ME, Stiles GL. Adenosine receptors. Annual Review of Physiology. 54: 211-25. PMID 1373278 DOI: 10.1146/annurev.ph.54.030192.001235  0.482
1992 Zhou QY, Li C, Olah ME, Johnson RA, Stiles GL, Civelli O. Molecular cloning and characterization of an adenosine receptor: the A3 adenosine receptor. Proceedings of the National Academy of Sciences of the United States of America. 89: 7432-6. PMID 1323836 DOI: 10.1073/Pnas.89.16.7432  0.513
1991 Olah ME, Jacobson KA, Stiles GL. Purification and characterization of bovine cerebral cortex A1 adenosine receptor. Archives of Biochemistry and Biophysics. 283: 440-6. PMID 2275555 DOI: 10.1016/0003-9861(90)90665-L  0.619
1991 Boring DL, Ji XD, Zimmet J, Taylor KE, Stiles GL, Jacobson KA. Trifunctional agents as a design strategy for tailoring ligand properties: Irreversible inhibitors of A1 adenosine receptors Bioconjugate Chemistry. 2: 77-88. PMID 1868116 DOI: 10.1021/Bc00008A002  0.689
1991 Stiles GL. Adrenergic receptor responsiveness and congestive heart failure. The American Journal of Cardiology. 67: 13C-17C. PMID 1850573 DOI: 10.1016/0002-9149(91)90068-V  0.532
1990 Olah ME, Jacobson KA, Stiles GL. Affinity chromatography of the bovine cerebral cortex A1 adenosine receptor. Febs Letters. 257: 292-6. PMID 2583275 DOI: 10.1016/0014-5793(89)81555-8  0.726
1990 Jacobson KA, Pannell LK, Ji XD, Jarvis MF, Williams M, Hutchison AJ, Barrington WW, Stiles GL. Agonist derived molecular probes for A2 adenosine receptors. Journal of Molecular Recognition : Jmr. 2: 170-8. PMID 2561548 DOI: 10.1002/Jmr.300020406  0.714
1990 Olah M, Stiles GL. Agonists and antagonists recognize different but overlapping populations of A1 adenosine receptors: modulation of receptor number by MgCl2, solubilization, and guanine nucleotides. Journal of Neurochemistry. 55: 1432-8. PMID 2398364 DOI: 10.1111/J.1471-4159.1990.Tb03157.X  0.64
1989 Barrington WW, Jacobson KA, Hutchison AJ, Williams M, Stiles GL. Identification of the A2 adenosine receptor binding subunit by photoaffinity crosslinking. Proceedings of the National Academy of Sciences of the United States of America. 86: 6572-6. PMID 2771944 DOI: 10.1073/Pnas.86.17.6572  0.719
1989 Bumgarner JR, Ramkumar V, Stiles GL. Altered thyroid status regulates the adipocyte A1 adenosine receptor-adenylate cyclase system Life Sciences. 44: 1705-1712. PMID 2733548 DOI: 10.1016/0024-3205(89)90487-6  0.636
1989 Jacobson KA, Barone S, Kammula U, Stiles GL. Electrophilic derivatives of purines as irreversible inhibitors of A1 adenosine receptors. Journal of Medicinal Chemistry. 32: 1043-51. PMID 2709373 DOI: 10.1021/Jm00125A019  0.719
1989 Stiles GL. Mechanisms of Receptor Activation in Adenylate Cyclase Systems Journal of Cardiovascular Pharmacology. 14: S1-S5. DOI: 10.1097/00005344-198900145-00002  0.512
1988 Ramkumar V, Bumgarner JR, Jacobson KA, Stiles GL. Multiple components of the A1 adenosine receptor-adenylate cyclase system are regulated in rat cerebral cortex by chronic caffeine ingestion Journal of Clinical Investigation. 82: 242-247. PMID 3392208 DOI: 10.1172/Jci113577  0.706
1988 Ramkumar V, Pierson G, Stiles GL. Adenosine receptors: Clinical implications and biochemical mechanisms Progress in Drug Research. 32: 195-247. PMID 3146107 DOI: 10.1007/978-3-0348-9154-7_7  0.515
1988 Stiles GL. A1 adenosine receptor-G protein coupling in bovine brain membranes: effects of guanine nucleotides, salt, and solubilization. Journal of Neurochemistry. 51: 1592-8. PMID 3139838 DOI: 10.1111/J.1471-4159.1988.Tb01129.X  0.543
1988 Ramkumar V, Stiles GL. A novel site of action of a high affinity A1 adenosine receptor antagonist Biochemical and Biophysical Research Communications. 153: 939-944. PMID 3134023 DOI: 10.1016/S0006-291X(88)81318-4  0.539
1986 Stiles GL, Daly DT, Olsson RA. Characterization of the A1 adenosine receptor-adenylate cyclase system of cerebral cortex using an agonist photoaffinity ligand. Journal of Neurochemistry. 47: 1020-5. PMID 3018153 DOI: 10.1111/J.1471-4159.1986.Tb00715.X  0.631
1986 Green RM, Stiles GL. Chronic caffeine ingestion sensitizes the A1 adenosine receptor-adenylate cyclase system in rat cerebral cortex. The Journal of Clinical Investigation. 77: 222-7. PMID 3003150 DOI: 10.1172/JCI112280  0.626
1986 Stiles GL, Pierson G, Sunay S, Parsons WJ. The rat testicular A1 adenosine receptor-adenylate cyclase system. Endocrinology. 119: 1845-51. PMID 2944739 DOI: 10.1210/Endo-119-4-1845  0.672
1986 Stiles GL. Adenosine receptors: structure, function and regulation Trends in Pharmacological Sciences. 7: 486-490. DOI: 10.1016/0165-6147(86)90434-7  0.566
1985 Stiles GL, Strasser RH, Kilpatrick BF, Taylor SR, Lefkowitz RJ. Endogenous proteinases modulate the function of the beta-adrenergic receptor-adenylate cyclase system. Biochimica Et Biophysica Acta. 802: 390-8. PMID 6095918 DOI: 10.1016/0304-4165(84)90355-6  0.741
1985 Parsons WJ, Stiles GL. Methylxanthines as adenosine receptor antagonists. Annals of Internal Medicine. 103: 643. PMID 2994536 DOI: 10.7326/0003-4819-103-4-643_1  0.6
1985 Stiles GL. Deglycosylated mammalian beta 2-adrenergic receptors: effect on radioligand binding and peptide mapping. Archives of Biochemistry and Biophysics. 237: 65-71. PMID 2982329 DOI: 10.1016/0003-9861(85)90254-1  0.551
1984 Stiles GL, Strasser RH. The effect of reducing agents on the structure of mammalian beta-adrenergic receptors. Biochemical and Biophysical Research Communications. 116: 777-82. PMID 6316962 DOI: 10.1016/0006-291X(83)90592-2  0.643
1984 Lefkowitz RJ, Caron MG, Stiles GL. Mechanisms of membrane-receptor regulation. Biochemical, physiological, and clinical insights derived from studies of the adrenergic receptors. The New England Journal of Medicine. 310: 1570-9. PMID 6145093 DOI: 10.1056/Nejm198406143102406  0.72
1984 Stiles GL, Lefkowitz RJ. Cardiac adrenergic receptors. Annual Review of Medicine. 35: 149-64. PMID 6144285 DOI: 10.1146/Annurev.Me.35.020184.001053  0.624
1984 Stiles GL, Caron MG, Lefkowitz RJ. Beta-adrenergic receptors: biochemical mechanisms of physiological regulation. Physiological Reviews. 64: 661-743. PMID 6143332 DOI: 10.1152/Physrev.1984.64.2.661  0.68
1984 Strasser RH, Stiles GL, Lefkowitz RJ. Translocation and uncoupling of the beta-adrenergic receptor in rat lung after catecholamine promoted desensitization in vivo. Endocrinology. 115: 1392-400. PMID 6090100 DOI: 10.1210/Endo-115-4-1392  0.709
1983 Benovic JL, Stiles GL, Lefkowitz RJ, Caron MG. Photoaffinity labelling of mammalian beta-adrenergic receptors: Metal-dependent proteolysis explains apparent heterogeneity Biochemical and Biophysical Research Communications. 110: 504-511. PMID 6301455 DOI: 10.1016/0006-291X(83)91178-6  0.692
1983 Stiles GL, Hoffman BB, Hubbard M, Caron MG, Lefkowitz RJ. Guanine nucleotides and alpha 1 adrenergic receptors in the heart. Biochemical Pharmacology. 32: 69-71. PMID 6299299 DOI: 10.1016/0006-2952(83)90654-8  0.696
1983 Stiles GL, Taylor S, Lefkowitz RJ. Human cardiac beta-adrenergic receptors: subtype heterogeneity delineated by direct radioligand binding. Life Sciences. 33: 467-73. PMID 6135968 DOI: 10.1016/0024-3205(83)90796-8  0.605
1982 Stiles GL, Stadel JM, De Lean A, Lefkowitz RJ. Hypothyroidism modulates beta adrenergic receptor adenylate cyclase interactions in rat reticulocytes. The Journal of Clinical Investigation. 68: 1450-5. PMID 6274909 DOI: 10.1172/JCI110397  0.642
1982 Stiles GL, Lefkowitz RJ. A reconstitution assay for the guanine nucleotide regulatory protein of the adenylate cyclase system using turkey erythrocyte membranes as the acceptor preparation. Archives of Biochemistry and Biophysics. 217: 368-75. PMID 6127058 DOI: 10.1016/0003-9861(82)90513-6  0.53
1981 Stiles GL, Lefkowitz RJ. Thyroid hormone modulation of agonist--beta-adrenergic receptor interactions in the rat heart. Life Sciences. 28: 2529-36. PMID 6114379 DOI: 10.1016/0024-3205(81)90595-6  0.671
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