Lak Shin Jeong - Publications

Seoul National University, Seoul, South Korea 

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Year Citation  Score
2019 Yoon JS, Kim G, Jarhad DB, Kim HR, Shin YS, Qu S, Sahu PK, Kim HO, Lee HW, Wang SB, Kong YJ, Chang TS, Ogando NS, Kovacikova K, Snijder EJ, ... ... Jeong LS, et al. Design, Synthesis, and Anti-RNA Virus Activity of 6'-Fluorinated-Aristeromycin Analogues. Journal of Medicinal Chemistry. PMID 31244113 DOI: 10.1021/acs.jmedchem.9b00781  0.56
2019 Zhou L, Jiang Y, Liu X, Li L, Yang X, Dong C, Liu X, Lin Y, Li Y, Yu J, He R, Huang S, Liu G, Zhang Y, Jeong LS, et al. Promotion of tumor-associated macrophages infiltration by elevated neddylation pathway via NF-κB-CCL2 signaling in lung cancer. Oncogene. PMID 31243299 DOI: 10.1038/s41388-019-0840-4  0.44
2019 Jiang Y, Liang Y, Li L, Zhou L, Cheng W, Yang X, Yang X, Qi H, Yu J, Jeong LS, Hoffman RM, Zheng P, Jia L. Targeting neddylation inhibits intravascular survival and extravasation of cancer cells to prevent lung-cancer metastasis. Cell Biology and Toxicology. PMID 31140025 DOI: 10.1007/s10565-019-09472-w  0.44
2019 Yu J, Kim G, Jarhad DB, Kim HR, Jeong LS. Synthesis and anti-HIV activity of L-2',3'-Dideoxy-4'-selenonucleosides (L-4'-Se-ddNs). Archives of Pharmacal Research. PMID 31041687 DOI: 10.1007/s12272-019-01157-6  0.56
2019 Lee ZW, Kim BS, Jang KK, Bang YJ, Kim S, Ha NC, Jung YH, Lee HJ, Han HJ, Kim JS, Kim J, Sahu PK, Jeong LS, Kim MH, Choi SH. Small-molecule inhibitor of HlyU attenuates virulence of Vibrio species. Scientific Reports. 9: 4346. PMID 30867441 DOI: 10.1038/s41598-019-39554-y  0.44
2019 Jia X, Li C, Li L, Zhou L, Zhang W, Ni S, Lu Y, Chen L, Jeong LS, Yu J, Zhang Y, Zhang J, He S, Hu X, Sun H, et al. Neddylation inactivation facilitates FOXO3a nuclear export to suppress estrogen receptor transcription and improve fulvestrant sensitivity. Clinical Cancer Research : An Official Journal of the American Association For Cancer Research. PMID 30833270 DOI: 10.1158/1078-0432.CCR-18-2434  0.44
2018 Zhang W, Liang Y, Li L, Wang X, Yan Z, Dong C, Zeng MS, Zhong Q, Liu XK, Yu J, Sun S, Liu X, Kang J, Zhao H, Jeong LS, et al. The Nedd8-activating enzyme inhibitor MLN4924 (TAK-924/Pevonedistat) induces apoptosis via c-Myc-Noxa axis in head and neck squamous cell carcinoma. Cell Proliferation. e12536. PMID 30341788 DOI: 10.1111/cpr.12536  0.44
2018 Byun WS, Jin M, Yu J, Kim WK, Song J, Chung HJ, Jeong LS, Lee SK. A novel selenonucleoside suppresses tumor growth by targeting Skp2 degradation in paclitaxel-resistant prostate cancer. Biochemical Pharmacology. PMID 30292755 DOI: 10.1016/j.bcp.2018.10.002  0.44
2018 Yu J, Kim G, Jarhad DB, Lee HW, Lee J, Park CW, Ha H, Jeong LS. Correlation study between A adenosine receptor binding affinity and anti-renal interstitial fibrosis activity of truncated adenosine derivatives. Archives of Pharmacal Research. PMID 30264323 DOI: 10.1007/s12272-018-1079-2  0.56
2018 Jarhad DB, Mashelkar KK, Kim HR, Noh M, Jeong LS. Dual Specificity Tyrosine-Phosphorylation-Regulated Kinase 1a (DYRK1a) Kinase Inhibitors as Potential Therapeutics. Journal of Medicinal Chemistry. PMID 29985601 DOI: 10.1021/acs.jmedchem.8b00185  0.56
2018 Park JG, Jeong SJ, Yu J, Kim G, Jeong LS, Oh GT. LJ-1888, a selective antagonist for the A3 adenosine receptor, ameliorates the development of atherosclerosis and hypercholesterolemia in apolipoprotein E knock-out mice. Bmb Reports. PMID 29936931  0.44
2018 Yoon JS, Jarhad DB, Kim G, Nayak A, Zhao LX, Yu J, Kim HR, Lee JY, Mulamoottil VA, Chandra G, Byun WS, Lee SK, Kim YC, Jeong LS. Design, synthesis and anticancer activity of fluorocyclopentenyl-purines and - pyrimidines. European Journal of Medicinal Chemistry. 155: 406-417. PMID 29906687 DOI: 10.1016/j.ejmech.2018.06.003  0.56
2017 Kim G, Yoon JS, Jarhad DB, Shin YS, Majik MS, Mulamoottil VA, Hou X, Qu S, Park J, Baik MH, Jeong LS. Asymmetric Synthesis of (-)-6'-β-Fluoro-aristeromycin via Stereoselective Electrophilic Fluorination. Organic Letters. PMID 29028350 DOI: 10.1021/acs.orglett.7b02470  0.56
2017 Lee S, Lee DH, Kim JC, Um BH, Sung SH, Jeong LS, Kim YK, Kim SN. Pectolinarigenin, an aglycone of pectolinarin, has more potent inhibitory activities on melanogenesis than pectolinarin. Biochemical and Biophysical Research Communications. PMID 28851651 DOI: 10.1016/j.bbrc.2017.08.106  0.44
2017 Yu J, Ahn S, Kim HJ, Lee M, Ahn S, Kim J, Jin SH, Lee E, Kim G, Cheong JH, Jacobson KA, Jeong LS, Noh M. Polypharmacology of N6-(3-iodobenzyl)adenosine-5'-N-methyluronamide (IB-MECA) and Related A3 Adenosine Receptor Ligands: Peroxisome Proliferator Activated Receptor (PPAR) γ Partial Agonist and PPAR δ Antagonist Activity Suggests Their Anti-diabetic Potential. Journal of Medicinal Chemistry. PMID 28799755 DOI: 10.1021/acs.jmedchem.7b00805  0.56
2017 Lee JY, Park JH, Kim KT, Yu J, Sahu PK, Kang N, Shin HJ, Kim MH, Kim JS, Yoon IS, Jeong LS, Kim DD. Determination and validation of LJ-2698, a potent human A3 adenosine receptor antagonist, in rat plasma by liquid chromatography-tandem mass spectrometry and its application in pharmacokinetic study. Archives of Pharmacal Research. PMID 28756559 DOI: 10.1007/s12272-017-0935-9  0.44
2017 Sahu PK, Umme T, Yu J, Kim G, Qu S, Naik SD, Jeong LS. Structure-Activity Relationships of Acyclic Selenopurine Nucleosides as Antiviral Agents. Molecules (Basel, Switzerland). 22. PMID 28704950 DOI: 10.3390/molecules22071167  0.44
2017 Wang J, Wang S, Zhang W, Wang X, Liu X, Liu L, Li L, Liang Y, Yu J, Jeong LS, Jia L, Zhao H, Zhang Y. Targeting neddylation pathway with MLN4924 (Pevonedistat) induces NOXA-dependent apoptosis in renal cell carcinoma. Biochemical and Biophysical Research Communications. PMID 28669728 DOI: 10.1016/j.bbrc.2017.06.179  0.44
2017 Sahu PK, Jarhad DB, Kim G, Jeong LS. Stereoselective Synthesis of 4'-Selenonucleosides via the Seleno-Michael Reaction. Current Protocols in Nucleic Acid Chemistry. 69: 14.13.1-14.13.15. PMID 28628205 DOI: 10.1002/cpnc.27  0.56
2017 Yu J, Zhao LX, Park J, Lee HW, Sahu PK, Cui M, Moss SM, Hammes E, Warnick E, Gao ZG, Noh M, Choi S, Ahn HC, Choi J, Jacobson KA, ... Jeong LS, et al. N6-Substituted-5'-N-Methylcarbamoyl-4'-selenoadenosines as Potent and Selective A3 Adenosine Receptor Agonists with Unusual Sugar Puckering and Nucleobase Orientation. Journal of Medicinal Chemistry. PMID 28380296 DOI: 10.1021/acs.jmedchem.7b00241  0.56
2016 Franchini S, Battisti UM, Sorbi C, Tait A, Cornia A, Jeong LS, Lee SK, Song J, Loddo R, Madeddu S, Sanna G, Brasili L. Synthesis, structural characterization and biological evaluation of 4'-C-methyl- and phenyl-dioxolane pyrimidine and purine nucleosides. Archives of Pharmacal Research. PMID 27615010 DOI: 10.1007/s12272-016-0825-6  0.44
2016 Min HS, Cha JJ, Kim K, Kim JE, Ghee JY, Kim H, Lee JE, Han JY, Jeong LS, Cha DR, Kang YS. Renoprotective Effects of a Highly Selective A3 Adenosine Receptor Antagonist in a Mouse Model of Adriamycin-induced Nephropathy. Journal of Korean Medical Science. 31: 1403-12. PMID 27510383 DOI: 10.3346/jkms.2016.31.9.1403  0.44
2016 Qu S, Mulamoottil VA, Nayak A, Ryu S, Hou X, Song J, Yu J, Sahu PK, Zhao LX, Choi S, Lee SK, Jeong LS. Design, synthesis, and anticancer activity of C8-substituted-4'-thionucleosides as potential HSP90 inhibitors. Bioorganic & Medicinal Chemistry. PMID 27283788 DOI: 10.1016/j.bmc.2016.05.041  0.44
2016 Wang X, Zhang W, Yan Z, Liang Y, Li L, Yu X, Feng Y, Fu S, Zhang Y, Zhao H, Yu J, Jeong LS, Guo X, Jia L. Radiosensitization by the investigational NEDD8-activating enzyme inhibitor MLN4924 (pevonedistat) in hormone-resistant prostate cancer cells. Oncotarget. PMID 27224919 DOI: 10.18632/oncotarget.9526  0.44
2016 Kim BK, Ko H, Jeon ES, Ju ES, Jeong LS, Kim YC. 2,3,4-Trihydroxybenzyl-hydrazide analogues as novel potent coxsackievirus B3 3C protease inhibitors. European Journal of Medicinal Chemistry. 120: 202-216. PMID 27191615 DOI: 10.1016/j.ejmech.2016.03.085  0.32
2016 Park HS, Ju UI, Park JW, Song JY, Shin DH, Lee KH, Jeong LS, Yu J, Lee HW, Cho JY, Kim SY, Kim SW, Kim JB, Park KS, Chun YS. PPARγ neddylation essential for adipogenesis is a potential target for treating obesity. Cell Death and Differentiation. PMID 26990658 DOI: 10.1038/cdd.2016.6  0.44
2016 Chen P, Hu T, Liang Y, Li P, Chen X, Zhang J, Ma Y, Hao Q, Wang J, Zhang P, Zhang Y, Zhao H, Yang S, Yu J, Jeong LS, et al. Neddylation Inhibition Activates the Extrinsic Apoptosis Pathway through ATF4-CHOP-DR5 Axis in Human Esophageal Cancer Cells. Clinical Cancer Research : An Official Journal of the American Association For Cancer Research. PMID 26983464 DOI: 10.1158/1078-0432.CCR-15-2254  0.44
2015 Sahu PK, Umme T, Yu J, Nayak A, Kim G, Noh M, Lee JY, Kim DD, Jeong LS. Seleno-acyclovir and -ganciclovir: A Discovery of a New Template for Antiviral Agents. Journal of Medicinal Chemistry. PMID 26460883 DOI: 10.1021/acs.jmedchem.5b00804  0.44
2015 Yu J, Sahu PK, Kim G, Qu S, Choi Y, Song J, Lee SK, Noh M, Park S, Jeong LS. Design, synthesis and cellular metabolism study of 4'-selenonucleosides. Future Medicinal Chemistry. PMID 26399780 DOI: 10.4155/fmc.15.102  0.44
2015 Kim G, Choi Y, Sahu PK, Yu J, Qu S, Lee D, Jeong LS. Stereoselective Synthesis of d-5-Homo-4-selenoribose as a Versatile Intermediate for 4'-Selenonucleosides. Organic Letters. 17: 4636-9. PMID 26348005 DOI: 10.1021/acs.orglett.5b02393  0.44
2015 Nayak A, Sahu PK, Song J, Lee SK, Jeong LS. Regio- and stereoselective synthesis of 2'-β-substituted-fluoroneplanocin A analogues as potential anticancer agents. Organic & Biomolecular Chemistry. PMID 26224319 DOI: 10.1039/c5ob01348h  0.44
2015 Chandra G, Moon YW, Lee Y, Jang JY, Song J, Nayak A, Oh K, Mulamoottil VA, Sahu PK, Kim G, Chang TS, Noh M, Lee SK, Choi S, Jeong LS. Structure-Activity Relationships of Neplanocin A Analogues as S-Adenosylhomocysteine Hydrolase Inhibitors and Their Antiviral and Antitumor Activities. Journal of Medicinal Chemistry. 58: 5108-20. PMID 26010585 DOI: 10.1021/acs.jmedchem.5b00553  0.44
2015 Ahn S, Yi S, Seo WJ, Lee MJ, Song YK, Baek SY, Yu J, Hong SH, Lee J, Shin DW, Jeong LS, Noh M. A cannabinoid receptor agonist N-arachidonoyl dopamine inhibits adipocyte differentiation in human mesenchymal stem cells. Biomolecules & Therapeutics. 23: 218-24. PMID 25995819 DOI: 10.4062/biomolther.2014.137  0.44
2015 Alexander V, Song J, Yu J, Choi JH, Kim JH, Lee SK, Choi WJ, Jeong LS. Synthesis and biological evaluation of 2'-substituted-4'-selenoribofuranosyl pyrimidines as antitumor agents. Archives of Pharmacal Research. 38: 966-72. PMID 25239109 DOI: 10.1007/s12272-014-0466-6  0.52
2014 Sahu PK, Kim G, Yu J, Ahn JY, Song J, Choi Y, Jin X, Kim JH, Lee SK, Park S, Jeong LS. Stereoselective synthesis of 4'-selenonucleosides via seleno-Michael reaction as potent antiviral agents. Organic Letters. 16: 5796-9. PMID 25340622 DOI: 10.1021/ol502899b  0.44
2014 Kim JH, Yu J, Alexander V, Choi JH, Song J, Lee HW, Kim HO, Choi J, Lee SK, Jeong LS. Structure-activity relationships of 2'-modified-4'-selenoarabinofuranosyl-pyrimidines as anticancer agents. European Journal of Medicinal Chemistry. 83: 208-25. PMID 24956556 DOI: 10.1016/j.ejmech.2014.06.031  0.52
2014 Li L, Wang M, Yu G, Chen P, Li H, Wei D, Zhu J, Xie L, Jia H, Shi J, Li C, Yao W, Wang Y, Gao Q, Jeong LS, et al. Overactivated neddylation pathway as a therapeutic target in lung cancer. Journal of the National Cancer Institute. 106: dju083. PMID 24853380 DOI: 10.1093/jnci/dju083  0.44
2014 Yao WT, Wu JF, Yu GY, Wang R, Wang K, Li LH, Chen P, Jiang YN, Cheng H, Lee HW, Yu J, Qi H, Yu XJ, Wang P, Chu YW, ... ... Jeong LS, et al. Suppression of tumor angiogenesis by targeting the protein neddylation pathway. Cell Death & Disease. 5: e1059. PMID 24525735 DOI: 10.1038/cddis.2014.21  0.44
2014 Nayak A, Chandra G, Hwang I, Kim K, Hou X, Kim HO, Sahu PK, Roy KK, Yoo J, Lee Y, Cui M, Choi S, Moss SM, Phan K, Gao ZG, ... ... Jeong LS, et al. Synthesis and anti-renal fibrosis activity of conformationally locked truncated 2-hexynyl-N(6)-substituted-(N)-methanocarba-nucleosides as A3 adenosine receptor antagonists and partial agonists. Journal of Medicinal Chemistry. 57: 1344-54. PMID 24456490 DOI: 10.1021/jm4015313  0.44
2013 Peters GJ, Smid K, Vecchi L, Kathmann I, Sarkisjan D, Honeywell RJ, Losekoot N, Ohne O, Orbach A, Blaugrund E, Jeong LS, Lee YB, Ahn CH, Kim DJ. Metabolism, mechanism of action and sensitivity profile of fluorocyclopentenylcytosine (RX-3117; TV-1360). Investigational New Drugs. 31: 1444-57. PMID 24048768 DOI: 10.1007/s10637-013-0025-x  0.44
2013 Lee J, Hwang I, Lee JH, Lee HW, Jeong LS, Ha H. The selective A3AR antagonist LJ-1888 ameliorates UUO-induced tubulointerstitial fibrosis. The American Journal of Pathology. 183: 1488-97. PMID 24001475 DOI: 10.1016/j.ajpath.2013.07.010  0.44
2013 Kim GD, Oh J, Jeong LS, Lee SK. Thio-Cl-IB-MECA, a novel A₃ adenosine receptor agonist, suppresses angiogenesis by regulating PI3K/AKT/mTOR and ERK signaling in endothelial cells. Biochemical and Biophysical Research Communications. 437: 79-86. PMID 23791876 DOI: 10.1016/j.bbrc.2013.06.040  0.44
2013 Yu J, Kim JH, Lee HW, Alexander V, Ahn HC, Choi WJ, Choi J, Jeong LS. New RNA purine building blocks, 4'-selenopurine nucleosides: first synthesis and unusual mixture of sugar puckerings. Chemistry (Weinheim An Der Bergstrasse, Germany). 19: 5528-32. PMID 23553943 DOI: 10.1002/chem.201300741  0.52
2013 Li L, Liu B, Dong T, Lee HW, Yu J, Zheng Y, Gao H, Zhang Y, Chu Y, Liu G, Niu W, Zheng S, Jeong LS, Jia L. Neddylation pathway regulates the proliferation and survival of macrophages. Biochemical and Biophysical Research Communications. 432: 494-8. PMID 23416079 DOI: 10.1016/j.bbrc.2013.02.028  0.44
2013 Zuo W, Huang F, Chiang YJ, Li M, Du J, Ding Y, Zhang T, Lee HW, Jeong LS, Chen Y, Deng H, Feng XH, Luo S, Gao C, Chen YG. c-Cbl-mediated neddylation antagonizes ubiquitination and degradation of the TGF-β type II receptor. Molecular Cell. 49: 499-510. PMID 23290524 DOI: 10.1016/j.molcel.2012.12.002  0.44
2012 Kang HJ, Voleti B, Hajszan T, Rajkowska G, Stockmeier CA, Licznerski P, Lepack A, Majik MS, Jeong LS, Banasr M, Son H, Duman RS. Decreased expression of synapse-related genes and loss of synapses in major depressive disorder. Nature Medicine. 18: 1413-7. PMID 22885997 DOI: 10.1038/nm.2886  0.44
2012 Luo Z, Yu G, Lee HW, Li L, Wang L, Yang D, Pan Y, Ding C, Qian J, Wu L, Chu Y, Yi J, Wang X, Sun Y, Jeong LS, et al. The Nedd8-activating enzyme inhibitor MLN4924 induces autophagy and apoptosis to suppress liver cancer cell growth. Cancer Research. 72: 3360-71. PMID 22562464 DOI: 10.1158/0008-5472.CAN-12-0388  0.44
2012 Chandra G, Alexander V, Lee HW, Jeong LS. Improved synthesis of a DNA-dependent protein kinase inhibitor IC86621. Archives of Pharmacal Research. 35: 639-45. PMID 22553056 DOI: 10.1007/s12272-012-0407-1  0.44
2012 Choi WJ, Chung HJ, Chandra G, Alexander V, Zhao LX, Lee HW, Nayak A, Majik MS, Kim HO, Kim JH, Lee YB, Ahn CH, Lee SK, Jeong LS. Fluorocyclopentenyl-cytosine with broad spectrum and potent antitumor activity. Journal of Medicinal Chemistry. 55: 4521-5. PMID 22524616 DOI: 10.1021/jm3004009  0.52
2012 Hou X, Majik MS, Kim K, Pyee Y, Lee Y, Alexander V, Chung HJ, Lee HW, Chandra G, Lee JH, Park SG, Choi WJ, Kim HO, Phan K, Gao ZG, ... ... Jeong LS, et al. Structure-activity relationships of truncated C2- or C8-substituted adenosine derivatives as dual acting A₂A and A₃ adenosine receptor ligands. Journal of Medicinal Chemistry. 55: 342-56. PMID 22142423 DOI: 10.1021/jm201229j  0.44
2011 Lee HW, Choi WJ, Jacobson KA, Jeong LS. Synthesis and Binding Affinity of Homologated Adenosine Analogues as A3 Adenosine Receptor Ligands. Bulletin of the Korean Chemical Society. 32: 1620-1624. PMID 26120223 DOI: 10.5012/bkcs.2011.32.5.1620  0.52
2011 Lee Y, Jeong LS, Choi S, Hyeon C. Link between allosteric signal transduction and functional dynamics in a multisubunit enzyme: S-adenosylhomocysteine hydrolase. Journal of the American Chemical Society. 133: 19807-15. PMID 22023331 DOI: 10.1021/ja2066175  0.44
2011 Lee SH, Kim IS, Li QR, Dong GR, Jeong LS, Jung YH. Stereoselective amination of chiral benzylic ethers using chlorosulfonyl isocyanate: total synthesis of (+)-sertraline. The Journal of Organic Chemistry. 76: 10011-9. PMID 22022991 DOI: 10.1021/jo201794k  0.44
2011 Kang JA, Yang Z, Lee JY, De U, Kim TH, Park JY, Lee HJ, Park YJ, Chun P, Kim HS, Jeong LS, Moon HR. Design, synthesis and anticancer activity of novel dihydrobenzofuro[4,5-b][1,8]naphthyridin-6-one derivatives. Bioorganic & Medicinal Chemistry Letters. 21: 5730-4. PMID 21885273 DOI: 10.1016/j.bmcl.2011.08.016  0.44
2011 Choi MJ, Chandra G, Lee HW, Hou X, Choi WJ, Phan K, Jacobson KA, Jeong LS. Regio- and stereoselective synthesis of truncated 3'-aminocarbanucleosides and their binding affinity at the A3 adenosine receptor. Organic & Biomolecular Chemistry. 9: 6955-62. PMID 21860878 DOI: 10.1039/c1ob05853c  0.44
2011 Choi IY, Lee JC, Ju C, Hwang S, Cho GS, Lee HW, Choi WJ, Jeong LS, Kim WK. A3 adenosine receptor agonist reduces brain ischemic injury and inhibits inflammatory cell migration in rats. The American Journal of Pathology. 179: 2042-52. PMID 21854743 DOI: 10.1016/j.ajpath.2011.07.006  0.44
2011 Lee HS, Chung HJ, Lee HW, Jeong LS, Lee SK. Suppression of inflammation response by a novel A₃ adenosine receptor agonist thio-Cl-IB-MECA through inhibition of Akt and NF-κB signaling. Immunobiology. 216: 997-1003. PMID 21514967 DOI: 10.1016/j.imbio.2011.03.008  0.44
2011 Park J, Kwon MK, Huh JY, Choi WJ, Jeong LS, Nagai R, Kim WY, Kim J, Lee GT, Lee HB, Ha H. Renoprotective antioxidant effect of alagebrium in experimental diabetes. Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association. 26: 3474-84. PMID 21478303 DOI: 10.1093/ndt/gfr152  0.44
2011 Lee HW, Nam SK, Choi WJ, Kim HO, Jeong LS. Stereoselective synthesis of MLN4924, an inhibitor of NEDD8-activating enzyme. The Journal of Organic Chemistry. 76: 3557-61. PMID 21417215 DOI: 10.1021/jo2001897  0.44
2011 Lee KM, Choi WJ, Lee Y, Lee HJ, Zhao LX, Lee HW, Park JG, Kim HO, Hwang KY, Heo YS, Choi S, Jeong LS. X-ray crystal structure and binding mode analysis of human S-adenosylhomocysteine hydrolase complexed with novel mechanism-based inhibitors, haloneplanocin A analogues. Journal of Medicinal Chemistry. 54: 930-8. PMID 21226494 DOI: 10.1021/jm1010836  0.52
2010 Hou X, Kim HO, Alexander V, Kim K, Choi S, Park SG, Lee JH, Yoo LS, Gao ZG, Jacobson KA, Jeong LS. Discovery of New Human A(2A) Adenosine Receptor Agonists: Design, Synthesis, and Binding Mode of Truncated 2-Hexynyl-4'-thioadenosine. Acs Medicinal Chemistry Letters. 2010: 516-520. PMID 21286238 DOI: 10.1021/ml1001823  0.44
2010 Lee HW, Kim HO, Choi WJ, Choi S, Lee JH, Park SG, Yoo L, Jacobson KA, Jeong LS. Design, synthesis, and binding of homologated truncated 4'-thioadenosine derivatives at the human A3 adenosine receptors. Bioorganic & Medicinal Chemistry. 18: 7015-21. PMID 20826090 DOI: 10.1016/j.bmc.2010.08.018  0.44
2010 Kim H, Kang JW, Lee S, Choi WJ, Jeong LS, Yang Y, Hong JT, Yoon DY. A3 adenosine receptor antagonist, truncated Thio-Cl-IB-MECA, induces apoptosis in T24 human bladder cancer cells. Anticancer Research. 30: 2823-30. PMID 20683018  0.52
2010 Choi WJ, Kim YM, Kim HO, Lee HW, Kim DE, Park KS, Chong Y, Jeong LS. Synthesis and anti-hepatitis C virus (HCV) activity of 3'-C-substituted-methyl pyrimidine and purine nucleosides. Bioorganic & Medicinal Chemistry. 18: 4812-20. PMID 20627592 DOI: 10.1016/j.bmc.2010.05.002  0.52
2010 Alexander V, Choi WJ, Chun J, Kim HO, Jeon JH, Tosh DK, Lee HW, Chandra G, Choi J, Jeong LS. A new DNA building block, 4'-selenothymidine: synthesis and modification to 4'-seleno-AZT as a potential anti-HIV agent. Organic Letters. 12: 2242-5. PMID 20405850 DOI: 10.1021/ol1005906  0.52
2010 Wang Z, Do CW, Avila MY, Peterson-Yantorno K, Stone RA, Gao ZG, Joshi B, Besada P, Jeong LS, Jacobson KA, Civan MM. Nucleoside-derived antagonists to A3 adenosine receptors lower mouse intraocular pressure and act across species. Experimental Eye Research. 90: 146-54. PMID 19878673 DOI: 10.1016/j.exer.2009.10.001  0.44
2009 Park YH, Choi WJ, Tipnis AS, Lee KM, Jeong LS. Truncated fluorocyclopentenyl pyrimidines as S-adenosylhomocysteine hydrolase inhibitors. Nucleosides, Nucleotides & Nucleic Acids. 28: 601-13. PMID 20183604 DOI: 10.1080/15257770903054316  0.52
2009 Choi WJ, Lee HW, Kim HO, Chinn M, Gao ZG, Patel A, Jacobson KA, Moon HR, Jung YH, Jeong LS. Design and synthesis of N(6)-substituted-4'-thioadenosine-5'-uronamides as potent and selective human A(3) adenosine receptor agonists. Bioorganic & Medicinal Chemistry. 17: 8003-11. PMID 19879151 DOI: 10.1016/j.bmc.2009.10.011  0.44
2009 Kim WH, Kang JA, Lee HR, Park AY, Chun P, Lee B, Kim J, Kim JA, Jeong LS, Moon HR. Efficient and practical synthesis of L-hamamelose. Carbohydrate Research. 344: 2317-21. PMID 19818955 DOI: 10.1016/j.carres.2009.09.011  0.44
2009 Jeong LS, Tosh DK, Choi WJ. Development of next generation 4'-selenonucleosides Nucleic Acids Symposium Series (2004). 7-8. PMID 19749233  0.44
2009 Jeong LS, Tosh DK, Choi WJ, Lee SK, Kang YJ, Choi S, Lee JH, Lee H, Lee HW, Kim HO. Discovery of a new template for anticancer agents: 2'-deoxy-2'-fluoro-4'-selenoarabinofuranosyl-cytosine (2'-F-4'-seleno-ara-C). Journal of Medicinal Chemistry. 52: 5303-6. PMID 19691349 DOI: 10.1021/jm900852b  0.52
2009 Pal S, Choi WJ, Choe SA, Heller CL, Gao ZG, Chinn M, Jacobson KA, Hou X, Lee SK, Kim HO, Jeong LS. Structure-activity relationships of truncated adenosine derivatives as highly potent and selective human A3 adenosine receptor antagonists. Bioorganic & Medicinal Chemistry. 17: 3733-8. PMID 19375920 DOI: 10.1016/j.bmc.2009.03.034  0.44
2008 Jeong LS, Choi YN, Tosh DK, Choi WJ, Kim HO, Choi J. Design and synthesis of novel 2',3'-dideoxy-4'-selenonucleosides as potential antiviral agents. Bioorganic & Medicinal Chemistry. 16: 9891-7. PMID 18977147 DOI: 10.1016/j.bmc.2008.10.034  0.52
2008 Jeong LS, Tosh DK, Choi WJ, Pal S. Synthesis of fluoroneplanocin A Current Protocols in Nucleic Acid Chemistry / Edited by Serge L. Beaucage ... [Et Al.]. PMID 18819082 DOI: 10.1002/0471142700.nc1406s34  0.44
2008 Jeong LS, Pal S, Choe SA, Choi WJ, Jacobson KA, Gao ZG, Klutz AM, Hou X, Kim HO, Lee HW, Lee SK, Tosh DK, Moon HR. Structure-activity relationships of truncated D- and l-4'-thioadenosine derivatives as species-independent A3 adenosine receptor antagonists. Journal of Medicinal Chemistry. 51: 6609-13. PMID 18811138 DOI: 10.1021/jm8008647  0.32
2008 Liang CW, Choi WJ, Jeong LS. Synthesis of 2-alkynyl substituted 4′-thioadenosine derivatives and their binding affinities at the adenosine receptors Archives of Pharmacal Research. 31: 973-977. PMID 18787783 DOI: 10.1007/s12272-001-1254-x  0.44
2008 Park AY, Kim KR, Lee HR, Kang JA, Kim WH, Jeong LS, Moon HR. Synthesis and biological evaluation of 5''-iodoneplanocin A and its analogues. Nucleic Acids Symposium Series (2004). 653-4. PMID 18776549 DOI: 10.1093/nass/nrn330  0.44
2008 Choi WJ, Lee HW, Hou X, Kim HO, Jacobson KA, Jeong LS. Synthesis of 2-chloro-N6-substituted-4'-thioadenosine-5'-N, N-dialkyluronamides as potent and selective A3 adenosine receptor antagonists. Nucleic Acids Symposium Series (2004). 645-6. PMID 18776545 DOI: 10.1093/nass/nrn326  0.44
2008 Hou X, Pal S, Choi WJ, Kim HO, Tipnis A, Jacobson KA, Jeong LS. Design and synthesis of truncated 4'-thioadenosine derivatives as potent and selective A3 adenosine receptor antagonists. Nucleic Acids Symposium Series (2004). 641-2. PMID 18776543 DOI: 10.1093/nass/nrn324  0.44
2008 Lee H, Tosh DK, Choi WJ, Kim YM, Lee SK, Jeong LS. Synthesis and antitumor activity of 1-beta-4-selenoarabinofuranosyl cytosine (4'-seleno-ara-C). Nucleic Acids Symposium Series (2004). 639-40. PMID 18776542 DOI: 10.1093/nass/nrn323  0.52
2008 Kim WH, Kim KR, Park AY, Lee HR, Kang JA, Bae JH, Jeong LS, Moon HR. Synthesis and antiviral evaluation of conformationally fixed bicyclohexanyl nucleosides with ethenyl group at C3'-position. Nucleic Acids Symposium Series (2004). 621-2. PMID 18776533 DOI: 10.1093/nass/nrn314  0.44
2008 Kang JA, Park AY, Lee HR, Kim WH, Chun P, Jeong LS, Moon HR. Synthesis of novel cyclopropyl nucleoside analogues as potential antiherpetic agent. Nucleic Acids Symposium Series (2004). 613-4. PMID 18776529 DOI: 10.1093/nass/nrn310  0.44
2008 Lee HR, Kim WH, Park AY, Kang JA, Chun P, Bae JH, Jeong LS, Moon HR. Synthesis of pyrimidine analog of fluoroneplanocin A as potential anti-HCV agent. Nucleic Acids Symposium Series (2004). 607-8. PMID 18776526 DOI: 10.1093/nass/nrn307  0.44
2008 Ko YJ, Choi WJ, Jun JH, Zhao LX, Jeong LS. Synthesis and conformational analysis of novel 2',3'-didehydo-2',3'-dideoxy-4'-selenonucleosides Nucleic Acids Symposium Series (2004). 555-556. PMID 18776500  0.44
2008 Melman A, Wang B, Joshi BV, Gao ZG, Castro Sd, Heller CL, Kim SK, Jeong LS, Jacobson KA. Selective A(3) adenosine receptor antagonists derived from nucleosides containing a bicyclo[3.1.0]hexane ring system. Bioorganic & Medicinal Chemistry. 16: 8546-56. PMID 18752961 DOI: 10.1016/j.bmc.2008.08.007  0.44
2008 Pei X, Choi WJ, Kim YM, Zhao LX, Jeong LS. Synthesis of 3'-C-hydroxymethyl-substituted pyrimidine and purine nucleosides as potential anti-hepatitis C virus (HCV) agents. Archives of Pharmacal Research. 31: 843-9. PMID 18704325 DOI: 10.1007/s12272-001-1236-z  0.52
2008 Tosh DK, Choi WJ, Kim HO, Lee Y, Pal S, Hou X, Choi J, Choi S, Jeong LS. Stereoselective synthesis and conformational study of novel 2',3'-Didehydro-2',3'-dideoxy-4'-selenonucleosides. The Journal of Organic Chemistry. 73: 4259-62. PMID 18454552 DOI: 10.1021/jo8003277  0.52
2008 Chun MW, Choi SW, Kang TK, Choi WJ, Kim HO, Gao ZG, Jacobson KA, Jeong LS. Synthesis of 3'-acetamidoadenosine derivatives as potential A3 adenosine receptor agonists. Nucleosides, Nucleotides & Nucleic Acids. 27: 408-20. PMID 18404574 DOI: 10.1080/15257770801944436  0.52
2008 Kim SJ, Min HY, Chung HJ, Park EJ, Hong JY, Kang YJ, Shin DH, Jeong LS, Lee SK. Inhibition of cell proliferation through cell cycle arrest and apoptosis by thio-Cl-IB-MECA, a novel A3 adenosine receptor agonist, in human lung cancer cells. Cancer Letters. 264: 309-15. PMID 18321638 DOI: 10.1016/j.canlet.2008.01.037  0.44
2008 Jeong LS, Lee HW, Kim HO, Tosh DK, Pal S, Choi WJ, Gao ZG, Patel AR, Williams W, Jacobson KA, Kim HD. Structure-activity relationships of 2-chloro-N6-substituted-4'-thioadenosine-5'-N,N-dialkyluronamides as human A3 adenosine receptor antagonists. Bioorganic & Medicinal Chemistry Letters. 18: 1612-6. PMID 18255292 DOI: 10.1016/j.bmcl.2008.01.070  0.52
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