Richard A Flavell, Ph.D., FRS - Publications

Affiliations: 
Immunobiology Yale University, New Haven, CT 
Area:
Immunology
Website:
https://medicine.yale.edu/immuno/programs/richard_flavell.profile

500 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2020 Yang L, Geng T, Yang G, Ma J, Wang L, Ketkar H, Yang D, Lin T, Hwang J, Zhu S, Wang Y, Dai J, You F, Cheng G, Vella AT, ... Flavell RA, et al. Macrophage scavenger receptor 1 controls Chikungunya virus infection through autophagy in mice. Communications Biology. 3: 556. PMID 33033362 DOI: 10.1038/s42003-020-01285-6  0.36
2020 Duan Y, Li G, Xu M, Qi X, Deng M, Lin X, Lei Z, Hu Y, Jia Z, Yang Q, Cao G, Liu Z, Wen Q, Li Z, Tang J, ... ... Flavell RA, et al. CFTR is a negative regulator of γδ T cell IFN-γ production and antitumor immunity. Cellular & Molecular Immunology. PMID 32669666 DOI: 10.1038/s41423-020-0499-3  0.36
2020 Low JS, Farsakoglu Y, Amezcua Vesely MC, Sefik E, Kelly JB, Harman CCD, Jackson R, Shyer JA, Jiang X, Cauley LS, Flavell RA, Kaech SM. Tissue-resident memory T cell reactivation by diverse antigen-presenting cells imparts distinct functional responses. The Journal of Experimental Medicine. 217. PMID 32525985 DOI: 10.1084/jem.20192291  0.44
2020 Lim CX, Lee B, Geiger O, Passegger C, Beitzinger M, Romberger J, Stracke A, Högenauer C, Stift A, Stoiber H, Poidinger M, Zebisch A, Meister G, Williams A, Flavell RA, et al. miR-181a Modulation of ERK-MAPK Signaling Sustains DC-SIGN Expression and Limits Activation of Monocyte-Derived Dendritic Cells. Cell Reports. 30: 3793-3805.e5. PMID 32187550 DOI: 10.1016/j.celrep.2020.02.077  0.44
2020 Hwang SS, Lim J, Yu Z, Kong P, Sefik E, Xu H, Harman CCD, Kim LK, Lee GR, Li HB, Flavell RA. mRNA destabilization by BTG1 and BTG2 maintains T cell quiescence. Science (New York, N.Y.). 367: 1255-1260. PMID 32165587 DOI: 10.1126/science.aax0194  0.76
2020 Yang Q, Liu X, Liu Q, Guan Z, Luo J, Cao G, Cai R, Li Z, Xu Y, Wu Z, Xu M, Zhang S, Zhang F, Yang H, Lin X, ... ... Flavell R, et al. Roles of mTORC1 and mTORC2 in controlling γδ T1 and γδ T17 differentiation and function. Cell Death and Differentiation. PMID 32001780 DOI: 10.1038/s41418-020-0500-9  0.36
2019 Jang SW, Hwang SS, Kim HS, Kim MK, Lee WH, Hwang SU, Gwak J, Yew SK, Flavell RA, Lee GR. Homeobox protein Hhex negatively regulates Treg cells by inhibiting Foxp3 expression and function. Proceedings of the National Academy of Sciences of the United States of America. PMID 31792183 DOI: 10.1073/pnas.1907224116  0.76
2019 Lewandowski JP, Lee JC, Hwang T, Sunwoo H, Goldstein JM, Groff AF, Chang NP, Mallard W, Williams A, Henao-Meija J, Flavell RA, Lee JT, Gerhardinger C, Wagers AJ, Rinn JL. The Firre locus produces a trans-acting RNA molecule that functions in hematopoiesis. Nature Communications. 10: 5137. PMID 31723143 DOI: 10.1038/s41467-019-12970-4  0.44
2019 Amezcua Vesely MC, Pallis P, Bielecki P, Low JS, Zhao J, Harman CCD, Kroehling L, Jackson R, Bailis W, Licona-Limón P, Xu H, Iijima N, Pillai PS, Kaplan DH, Weaver CT, ... ... Flavell RA, et al. Effector T17 Cells Give Rise to Long-Lived T Cells that Are Essential for an Immediate Response against Bacterial Infection. Cell. 178: 1176-1188.e15. PMID 31442406 DOI: 10.1016/j.cell.2019.07.032  0.36
2019 Indrieri A, Carrella S, Romano A, Spaziano A, Marrocco E, Fernandez-Vizarra E, Barbato S, Pizzo M, Ezhova Y, Golia FM, Ciampi L, Tammaro R, Henao-Mejia J, Williams A, Flavell RA, et al. miR-181a/b downregulation exerts a protective action on mitochondrial disease models. Embo Molecular Medicine. PMID 30979712 DOI: 10.15252/emmm.201708734  0.44
2018 Shehata HM, Khan S, Chen E, Fields PE, Flavell RA, Sanjabi S. Lack of Sprouty 1 and 2 enhances survival of effector CD8 T cells and yields more protective memory cells. Proceedings of the National Academy of Sciences of the United States of America. PMID 30126987 DOI: 10.1073/pnas.1808320115  0.68
2018 Stefanski HE, Xing Y, Taylor PA, Maio S, Henao-Meija J, Williams A, Flavell RA, Hollander GA, Blazar BR. Despite high levels of expression in thymic epithelial cells, miR-181a1 and miR-181b1 are not required for thymic development. Plos One. 13: e0198871. PMID 29949604 DOI: 10.1371/journal.pone.0198871  0.44
2018 Herndler-Brandstetter D, Ishigame H, Shinnakasu R, Plajer V, Stecher C, Zhao J, Lietzenmayer M, Kroehling L, Takumi A, Kometani K, Inoue T, Kluger Y, Kaech SM, Kurosaki T, Okada T, ... Flavell RA, et al. KLRG1 Effector CD8 T Cells Lose KLRG1, Differentiate into All Memory T Cell Lineages, and Convey Enhanced Protective Immunity. Immunity. 48: 716-729.e8. PMID 29625895 DOI: 10.1016/j.immuni.2018.03.015  0.44
2018 Guan T, Dominguez CX, Amezquita RA, Laidlaw BJ, Cheng J, Henao-Mejia J, Williams A, Flavell RA, Lu J, Kaech SM. ZEB1, ZEB2, and the miR-200 family form a counterregulatory network to regulate CD8T cell fates. The Journal of Experimental Medicine. PMID 29449309 DOI: 10.1084/jem.20171352  0.44
2017 Kant S, Standen CL, Morel C, Jung DY, Kim JK, Swat W, Flavell RA, Davis RJ. A Protein Scaffold Coordinates SRC-Mediated JNK Activation in Response to Metabolic Stress. Cell Reports. 20: 2775-2783. PMID 28930674 DOI: 10.1016/j.celrep.2017.08.025  0.48
2017 Mowel WK, McCright SJ, Kotzin JJ, Collet MA, Uyar A, Chen X, DeLaney A, Spencer SP, Virtue AT, Yang E, Villarino A, Kurachi M, Dunagin MC, Pritchard GH, Stein J, ... ... Flavell RA, et al. Group 1 Innate Lymphoid Cell Lineage Identity Is Determined by a cis-Regulatory Element Marked by a Long Non-coding RNA. Immunity. 47: 435-449.e8. PMID 28930659 DOI: 10.1016/j.immuni.2017.08.012  0.44
2017 Cao G, Wang Q, Huang W, Tong J, Ye D, He Y, Liu Z, Tang X, Cheng H, Wen Q, Li D, Chau HT, Wen Y, Zhong H, Meng Z, ... ... Flavell RA, et al. Long-term consumption of caffeine-free high sucrose cola beverages aggravates the pathogenesis of EAE in mice. Cell Discovery. 3: 17020. PMID 28670480 DOI: 10.1038/celldisc.2017.20  0.36
2017 Zhu S, Ding S, Wang P, Wei Z, Pan W, Palm NW, Yang Y, Yu H, Li HB, Wang G, Lei X, de Zoete MR, Zhao J, Zheng Y, Chen H, ... ... Flavell RA, et al. Nlrp9b inflammasome restricts rotavirus infection in intestinal epithelial cells. Nature. PMID 28636595 DOI: 10.1038/nature22967  0.32
2017 Speir M, Vogrin A, Seidi A, Abraham G, Hunot S, Han Q, Dorn GW, Masters SL, Flavell RA, Vince JE, Naderer T. Legionella pneumophila Strain 130b Evades Macrophage Cell Death Independent of the Effector SidF in the Absence of Flagellin. Frontiers in Cellular and Infection Microbiology. 7: 35. PMID 28261564 DOI: 10.3389/fcimb.2017.00035  0.32
2017 Yu H, Borsotti C, Schickel JN, Zhu S, Strowig T, Eynon EE, Frleta D, Gurer C, Murphy AJ, Yancopoulos GD, Meffre E, Manz MG, Flavell RA. A novel humanized mouse model with significant improvement of class- switched, antigen-specific antibody production. Blood. PMID 28077418 DOI: 10.1182/blood-2016-04-709584  0.4
2016 Brockmann L, Gagliani N, Steglich B, Giannou AD, Kempski J, Pelczar P, Geffken M, Mfarrej B, Huber F, Herkel J, Wan YY, Esplugues E, Battaglia M, Krebs CF, Flavell RA, et al. IL-10 Receptor Signaling Is Essential for TR1 Cell Function In Vivo. Journal of Immunology (Baltimore, Md. : 1950). PMID 28003377 DOI: 10.4049/jimmunol.1601045  0.36
2016 Hu B, Jin C, Li HB, Tong J, Ouyang X, Cetinbas NM, Zhu S, Strowig T, Lam FC, Zhao C, Henao-Mejia J, Yilmaz O, Fitzgerald KA, Eisenbarth SC, Elinav E, ... Flavell RA, et al. The DNA-sensing AIM2 inflammasome controls radiation-induced cell death and tissue injury. Science (New York, N.Y.). 354: 765-768. PMID 27846608 DOI: 10.1126/science.aaf7532  0.44
2016 Paul AM, Acharya D, Le L, Wang P, Stokic DS, Leis AA, Alexopoulou L, Town T, Flavell RA, Fikrig E, Bai F. TLR8 Couples SOCS-1 and Restrains TLR7-Mediated Antiviral Immunity, Exacerbating West Nile Virus Infection in Mice. Journal of Immunology (Baltimore, Md. : 1950). PMID 27798161 DOI: 10.4049/jimmunol.1600902  0.64
2016 Acharya D, Wang P, Paul AM, Dai J, Gate D, Lowery JE, Stokic DS, Leis AA, Flavell RA, Town T, Fikrig E, Bai F. Interleukin-17A Promotes CD8+ T Cell Cytotoxicity to Facilitate West Nile Virus Clearance. Journal of Virology. PMID 27795421 DOI: 10.1128/JVI.01529-16  0.64
2016 Shen X, Burguillos MA, Osman AM, Frijhoff J, Carrillo-Jiménez A, Kanatani S, Augsten M, Saidi D, Rodhe J, Kavanagh E, Rongvaux A, Rraklli V, Nyman U, Holmberg J, Östman A, ... Flavell RA, et al. Glioma-induced inhibition of caspase-3 in microglia promotes a tumor-supportive phenotype. Nature Immunology. PMID 27618552 DOI: 10.1038/ni.3545  1
2016 Boddupalli CS, Nair S, Gray SM, Nowyhed HN, Verma R, Gibson JA, Abraham C, Narayan D, Vasquez J, Hedrick CC, Flavell RA, Dhodapkar KM, Kaech SM, Dhodapkar MV. ABC transporters and NR4A1 identify a quiescent subset of tissue-resident memory T cells. The Journal of Clinical Investigation. PMID 27617863 DOI: 10.1172/JCI85329  1
2016 Weinstein JS, Herman EI, Lainez B, Licona-Limón P, Esplugues E, Flavell R, Craft J. TFH cells progressively differentiate to regulate the germinal center response. Nature Immunology. PMID 27573866 DOI: 10.1038/ni.3554  1
2016 Kotzin JJ, Spencer SP, McCright SJ, Kumar DB, Collet MA, Mowel WK, Elliott EN, Uyar A, Makiya MA, Dunagin MC, Harman CC, Virtue AT, Zhu S, Bailis W, Stein J, ... ... Flavell RA, et al. The long non-coding RNA Morrbid regulates Bim and short-lived myeloid cell lifespan. Nature. PMID 27525555 DOI: 10.1038/nature19346  1
2016 Costa FR, Françozo MC, de Oliveira GG, Ignacio A, Castoldi A, Zamboni DS, Ramos SG, Câmara NO, de Zoete MR, Palm NW, Flavell RA, Silva JS, Carlos D. Gut microbiota translocation to the pancreatic lymph nodes triggers NOD2 activation and contributes to T1D onset. The Journal of Experimental Medicine. PMID 27325889 DOI: 10.1084/jem.20150744  1
2016 Krebs CF, Turner JE, Paust HJ, Kapffer S, Koyro T, Krohn S, Ufer F, Friese MA, Flavell RA, Stockinger B, Steinmetz OM, Stahl RA, Huber S, Panzer U. Plasticity of Th17 Cells in Autoimmune Kidney Diseases. Journal of Immunology (Baltimore, Md. : 1950). PMID 27271566 DOI: 10.4049/jimmunol.1501831  1
2016 Hwang SS, Kim LK, Lee GR, Flavell RA. Role of OCT-1 and partner proteins in T cell differentiation. Biochimica Et Biophysica Acta. PMID 27126747 DOI: 10.1016/j.bbagrm.2016.04.006  1
2016 Pillai PS, Molony RD, Martinod K, Dong H, Pang IK, Tal MC, Solis AG, Bielecki P, Mohanty S, Trentalange M, Homer RJ, Flavell RA, Wagner DD, Montgomery RR, Shaw AC, et al. Mx1 reveals innate pathways to antiviral resistance and lethal influenza disease. Science (New York, N.Y.). 352: 463-6. PMID 27102485 DOI: 10.1126/science.aaf3926  1
2016 Chan PY, Carrera Silva EA, De Kouchkovsky D, Joannas LD, Hao L, Hu D, Huntsman S, Eng C, Licona-Limón P, Weinstein JS, Herbert DR, Craft JE, Flavell RA, Repetto S, Correale J, et al. The TAM family receptor tyrosine kinase TYRO3 is a negative regulator of type 2 immunity. Science (New York, N.Y.). 352: 99-103. PMID 27034374 DOI: 10.1126/science.aaf1358  1
2016 Cheng J, Roden CA, Pan W, Zhu S, Baccei A, Pan X, Jiang T, Kluger Y, Weissman SM, Guo S, Flavell RA, Ding Y, Lu J. A Molecular Chipper technology for CRISPR sgRNA library generation and functional mapping of noncoding regions. Nature Communications. 7: 11178. PMID 27025950 DOI: 10.1038/ncomms11178  1
2016 Vernia S, Morel C, Madara JC, Cavanagh-Kyros J, Barrett T, Chase K, Kennedy NJ, Jung DY, Kim JK, Aronin N, Flavell RA, Lowell BB, Davis RJ. Excitatory transmission onto AgRP neurons is regulated by cJun NH2-terminal kinase 3 in response to metabolic stress. Elife. 5. PMID 26910012 DOI: 10.7554/eLife.10031  1
2016 Hwang SS, Jang SW, Kim MK, Kim LK, Kim BS, Kim HS, Kim K, Lee W, Flavell RA, Lee GR. YY1 inhibits differentiation and function of regulatory T cells by blocking Foxp3 expression and activity. Nature Communications. 7: 10789. PMID 26892542 DOI: 10.1038/ncomms10789  0.76
2016 Williams A, Henao-Mejia J, Flavell RA. Editing the Mouse Genome Using the CRISPR-Cas9 System. Cold Spring Harbor Protocols. 2016: pdb.top087536. PMID 26832693 DOI: 10.1101/pdb.top087536  1
2016 Henao-Mejia J, Williams A, Rongvaux A, Stein J, Hughes C, Flavell RA. Generation of Genetically Modified Mice Using the CRISPR-Cas9 Genome-Editing System. Cold Spring Harbor Protocols. 2016: pdb.prot090704. PMID 26832688 DOI: 10.1101/pdb.prot090704  1
2016 Matza D, Badou A, Klemic KG, Stein J, Govindarajulu U, Nadler MJ, Kinet JP, Peled A, Shapira OM, Kaczmarek LK, Flavell RA. T Cell Receptor Mediated Calcium Entry Requires Alternatively Spliced Cav1.1 Channels. Plos One. 11: e0147379. PMID 26815481 DOI: 10.1371/journal.pone.0147379  1
2015 Hong E, Usiskin IM, Bergamaschi C, Hanlon DJ, Edelson RL, Justesen S, Pavlakis GN, Flavell RA, Fahmy TM. Configuration-dependent presentation of multivalent IL-15:IL-15Rα enhances the antigen-specific T cell response and anti-tumor immunity. The Journal of Biological Chemistry. PMID 26719339 DOI: 10.1074/jbc.M115.695304  1
2015 Nowarski R, Jackson R, Gagliani N, de Zoete MR, Palm NW, Bailis W, Low JS, Harman CC, Graham M, Elinav E, Flavell RA. Epithelial IL-18 Equilibrium Controls Barrier Function in Colitis. Cell. 163: 1444-56. PMID 26638073 DOI: 10.1016/j.cell.2015.10.072  1
2015 Levy M, Thaiss CA, Zeevi D, Dohnalová L, Zilberman-Schapira G, Mahdi JA, David E, Savidor A, Korem T, Herzig Y, Pevsner-Fischer M, Shapiro H, Christ A, Harmelin A, Halpern Z, ... ... Flavell RA, et al. Microbiota-Modulated Metabolites Shape the Intestinal Microenvironment by Regulating NLRP6 Inflammasome Signaling. Cell. 163: 1428-43. PMID 26638072 DOI: 10.1016/j.cell.2015.10.048  0.76
2015 Paterka M, Siffrin V, Voss JO, Werr J, Hoppmann N, Gollan R, Belikan P, Bruttger J, Birkenstock J, Jung S, Esplugues E, Yogev N, Flavell RA, Bopp T, Zipp F. Gatekeeper role of brain antigen-presenting CD11c+ cells in neuroinflammation. The Embo Journal. PMID 26612827 DOI: 10.15252/embj.201591488  0.76
2015 Eisenbarth SC, Williams A, Colegio OR, Meng H, Strowig T, Rongvaux A, Henao-Mejia J, Thaiss CA, Joly S, Gonzalez DG, Xu L, Zenewicz LA, Haberman AM, Elinav E, Kleinstein SH, ... ... Flavell RA, et al. Corrigendum: NLRP10 is a NOD-like receptor essential to initiate adaptive immunity by dendritic cells. Nature. PMID 26605525 DOI: 10.1038/nature16074  0.6
2015 Wang P, Zhu S, Yang L, Cui S, Pan W, Jackson R, Zheng Y, Rongvaux A, Sun Q, Yang G, Gao S, Lin R, You F, Flavell R, Fikrig E. Nlrp6 regulates intestinal antiviral innate immunity. Science (New York, N.Y.). PMID 26494172 DOI: 10.1126/science.aab3145  1
2015 Jha A, Singh AK, Weissgerber P, Freichel M, Flockerzi V, Flavell RA, Jha MK. Essential roles for Cavβ2 and Cav1 channels in thymocyte development and T cell homeostasis. Science Signaling. 8: ra103. PMID 26486172 DOI: 10.1126/scisignal.aac7538  1
2015 Finethy R, Jorgensen I, Haldar AK, de Zoete MR, Strowig T, Flavell RA, Yamamoto M, Nagarajan UM, Miao EA, Coers J. Guanylate Binding Proteins Enable Rapid Activation of Canonical and Noncanonical Inflammasomes in Chlamydia-Infected Macrophages. Infection and Immunity. 83: 4740-9. PMID 26416908 DOI: 10.1128/IAI.00856-15  1
2015 Hu C, Ding H, Li Y, Pearson JA, Zhang X, Flavell RA, Wong FS, Wen L. NLRP3 deficiency protects from type 1 diabetes through the regulation of chemotaxis into the pancreatic islets. Proceedings of the National Academy of Sciences of the United States of America. PMID 26305961 DOI: 10.1073/pnas.1513509112  1
2015 Thiele K, Solano ME, Huber S, Flavell RA, Kessler T, Barikbin R, Jung R, Karimi K, Tiegs G, Arck PC. Prenatal Acetaminophen Affects Maternal Immune and Endocrine Adaptation to Pregnancy, Induces Placental Damage, and Impairs Fetal Development in Mice. The American Journal of Pathology. PMID 26254283 DOI: 10.1016/j.ajpath.2015.06.019  0.76
2015 Jones A, Opejin A, Henderson JG, Gross C, Jain R, Epstein JA, Flavell RA, Hawiger D. Peripherally Induced Tolerance Depends on Peripheral Regulatory T Cells That Require Hopx To Inhibit Intrinsic IL-2 Expression. Journal of Immunology (Baltimore, Md. : 1950). PMID 26170384 DOI: 10.4049/jimmunol.1500174  0.76
2015 Laidlaw BJ, Cui W, Amezquita RA, Gray SM, Guan T, Lu Y, Kobayashi Y, Flavell RA, Kleinstein SH, Craft J, Kaech SM. Production of IL-10 by CD4(+) regulatory T cells during the resolution of infection promotes the maturation of memory CD8(+) T cells. Nature Immunology. PMID 26147684 DOI: 10.1038/ni.3224  0.76
2015 Palm NW, de Zoete MR, Flavell RA. Immune-microbiota interactions in health and disease. Clinical Immunology (Orlando, Fla.). 159: 122-7. PMID 26141651 DOI: 10.1016/j.clim.2015.05.014  1
2015 Cardona M, López JA, Serafín A, Rongvaux A, Inserte J, García-Dorado D, Flavell R, Llovera M, Cañas X, Vázquez J, Sanchis D. Executioner Caspase-3 and 7 Deficiency Reduces Myocyte Number in the Developing Mouse Heart. Plos One. 10: e0131411. PMID 26121671 DOI: 10.1371/journal.pone.0131411  0.76
2015 Kim LK, Morita R, Kobayashi Y, Eisenbarth SC, Lee CG, Elias J, Eynon EE, Flavell RA. AMCase is a crucial regulator of type 2 immune responses to inhaled house dust mites. Proceedings of the National Academy of Sciences of the United States of America. 112: E2891-9. PMID 26038565 DOI: 10.1073/pnas.1507393112  1
2015 Pan W, Zhu S, Dai D, Liu Z, Li D, Li B, Gagliani N, Zheng Y, Tang Y, Weirauch MT, Chen X, Zhu W, Wang Y, Chen B, Qian Y, ... ... Flavell RA, et al. MiR-125a targets effector programs to stabilize Treg-mediated immune homeostasis. Nature Communications. 6: 7096. PMID 25963922 DOI: 10.1038/ncomms8096  1
2015 Gagliani N, Vesely MC, Iseppon A, Brockmann L, Xu H, Palm NW, de Zoete MR, Licona-Limón P, Paiva RS, Ching T, Weaver C, Zi X, Pan X, Fan R, Garmire LX, ... ... Flavell RA, et al. Th17 cells transdifferentiate into regulatory T cells during resolution of inflammation. Nature. 523: 221-5. PMID 25924064 DOI: 10.1038/nature14452  1
2015 Zhang Y, Nguyen T, Tang P, Kennedy NJ, Jiao H, Zhang M, Reynolds JM, Jaeschke A, Martin-Orozco N, Chung Y, He WM, Wang C, Jia W, Ge B, Davis RJ, ... Flavell RA, et al. Regulation of Adipose Tissue Inflammation and Insulin Resistance by MAPK Phosphatase 5. The Journal of Biological Chemistry. 290: 14875-83. PMID 25922079 DOI: 10.1074/jbc.M115.660969  1
2015 . Retraction for Theivanthiran et al., NOD2 signaling contributes to host defense in the lungs against Escherichia coli infection. Infection and Immunity. 83: 2199. PMID 25878164 DOI: 10.1128/IAI.00200-15  1
2015 Willinger T, Staron M, Ferguson SM, De Camilli P, Flavell RA. Dynamin 2-dependent endocytosis sustains T-cell receptor signaling and drives metabolic reprogramming in T lymphocytes. Proceedings of the National Academy of Sciences of the United States of America. 112: 4423-8. PMID 25831514 DOI: 10.1073/pnas.1504279112  1
2015 Macia L, Tan J, Vieira AT, Leach K, Stanley D, Luong S, Maruya M, Ian McKenzie C, Hijikata A, Wong C, Binge L, Thorburn AN, Chevalier N, Ang C, Marino E, ... ... Flavell RA, et al. Metabolite-sensing receptors GPR43 and GPR109A facilitate dietary fibre-induced gut homeostasis through regulation of the inflammasome. Nature Communications. 6: 6734. PMID 25828455 DOI: 10.1038/ncomms7734  1
2015 James SJ, Jiao H, Teh HY, Takahashi H, Png CW, Phoon MC, Suzuki Y, Sawasaki T, Xiao H, Chow VT, Yamamoto N, Reynolds JM, Flavell RA, Dong C, Zhang Y. MAPK Phosphatase 5 Expression Induced by Influenza and Other RNA Virus Infection Negatively Regulates IRF3 Activation and Type I Interferon Response. Cell Reports. PMID 25772359 DOI: 10.1016/j.celrep.2015.02.030  1
2015 Zorca CE, Kim LK, Kim YJ, Krause MR, Zenklusen D, Spilianakis CG, Flavell RA. Myosin VI regulates gene pairing and transcriptional pause release in T cells. Proceedings of the National Academy of Sciences of the United States of America. 112: E1587-93. PMID 25770220 DOI: 10.1073/pnas.1502461112  1
2015 Stratigi K, Kapsetaki M, Aivaliotis M, Town T, Flavell RA, Spilianakis CG. Spatial proximity of homologous alleles and long noncoding RNAs regulate a switch in allelic gene expression. Proceedings of the National Academy of Sciences of the United States of America. 112: E1577-86. PMID 25770217 DOI: 10.1073/pnas.1502182112  0.64
2015 Krishnaswamy JK, Singh A, Gowthaman U, Wu R, Gorrepati P, Sales Nascimento M, Gallman A, Liu D, Rhebergen AM, Calabro S, Xu L, Ranney P, Srivastava A, Ranson M, Gorham JD, ... ... Flavell RA, et al. Coincidental loss of DOCK8 function in NLRP10-deficient and C3H/HeJ mice results in defective dendritic cell migration. Proceedings of the National Academy of Sciences of the United States of America. 112: 3056-61. PMID 25713392 DOI: 10.1073/pnas.1501554112  1
2015 Ballinger MN, Newstead MW, Zeng X, Bhan U, Mo XM, Kunkel SL, Moore BB, Flavell R, Christman JW, Standiford TJ. IRAK-M promotes alternative macrophage activation and fibroproliferation in bleomycin-induced lung injury. Journal of Immunology (Baltimore, Md. : 1950). 194: 1894-904. PMID 25595781 DOI: 10.4049/jimmunol.1402377  1
2015 Deng K, Pertea M, Rongvaux A, Wang L, Durand CM, Ghiaur G, Lai J, McHugh HL, Hao H, Zhang H, Margolick JB, Gurer C, Murphy AJ, Valenzuela DM, Yancopoulos GD, ... ... Flavell RA, et al. Broad CTL response is required to clear latent HIV-1 due to dominance of escape mutations. Nature. 517: 381-5. PMID 25561180 DOI: 10.1038/nature14053  1
2015 Galluzzi L, Bravo-San Pedro JM, Vitale I, Aaronson SA, Abrams JM, Adam D, Alnemri ES, Altucci L, Andrews D, Annicchiarico-Petruzzelli M, Baehrecke EH, Bazan NG, Bertrand MJ, Bianchi K, Blagosklonny MV, ... ... Flavell RA, et al. Essential versus accessory aspects of cell death: recommendations of the NCCD 2015. Cell Death and Differentiation. 22: 58-73. PMID 25236395 DOI: 10.1038/cdd.2014.137  0.76
2015 Gagliani N, Huber S, Flavell R. Intestinal Regulatory CD4+ T Cells Mucosal Immunology: Fourth Edition. 1: 777-785. DOI: 10.1016/B978-0-12-415847-4.00038-0  0.76
2014 Rongvaux A, Jackson R, Harman CC, Li T, West AP, de Zoete MR, Wu Y, Yordy B, Lakhani SA, Kuan CY, Taniguchi T, Shadel GS, Chen ZJ, Iwasaki A, Flavell RA. Apoptotic caspases prevent the induction of type I interferons by mitochondrial DNA. Cell. 159: 1563-77. PMID 25525875 DOI: 10.1016/j.cell.2014.11.037  1
2014 Heisig M, Abraham NM, Liu L, Neelakanta G, Mattessich S, Sultana H, Shang Z, Ansari JM, Killiam C, Walker W, Cooley L, Flavell RA, Agaisse H, Fikrig E. Antivirulence properties of an antifreeze protein. Cell Reports. 9: 417-24. PMID 25373896 DOI: 10.1016/j.celrep.2014.09.034  1
2014 Wegiel B, Larsen R, Gallo D, Chin BY, Harris C, Mannam P, Kaczmarek E, Lee PJ, Zuckerbraun BS, Flavell R, Soares MP, Otterbein LE. Macrophages sense and kill bacteria through carbon monoxide-dependent inflammasome activation. The Journal of Clinical Investigation. 124: 4926-40. PMID 25295542 DOI: 10.1172/JCI72853  1
2014 Camirand G, Wang Y, Lu Y, Wan YY, Lin Y, Deng S, Guz G, Perkins DL, Finn PW, Farber DL, Flavell RA, Shlomchik WD, Lakkis FG, Rudd CE, Rothstein DM. CD45 ligation expands Tregs by promoting interactions with DCs. The Journal of Clinical Investigation. 124: 4603-13. PMID 25202978 DOI: 10.1172/JCI74087  1
2014 Palm NW, de Zoete MR, Cullen TW, Barry NA, Stefanowski J, Hao L, Degnan PH, Hu J, Peter I, Zhang W, Ruggiero E, Cho JH, Goodman AL, Flavell RA. Immunoglobulin A coating identifies colitogenic bacteria in inflammatory bowel disease. Cell. 158: 1000-10. PMID 25171403 DOI: 10.1016/j.cell.2014.08.006  1
2014 Shulman Z, Gitlin AD, Weinstein JS, Lainez B, Esplugues E, Flavell RA, Craft JE, Nussenzweig MC. Dynamic signaling by T follicular helper cells during germinal center B cell selection. Science (New York, N.Y.). 345: 1058-62. PMID 25170154 DOI: 10.1126/science.1257861  1
2014 Gate D, Danielpour M, Rodriguez J, Kim GB, Levy R, Bannykh S, Breunig JJ, Kaech SM, Flavell RA, Town T. T-cell TGF-β signaling abrogation restricts medulloblastoma progression. Proceedings of the National Academy of Sciences of the United States of America. 111: E3458-66. PMID 25082897 DOI: 10.1073/pnas.1412489111  1
2014 Chung LK, Philip NH, Schmidt VA, Koller A, Strowig T, Flavell RA, Brodsky IE, Bliska JB. IQGAP1 is important for activation of caspase-1 in macrophages and is targeted by Yersinia pestis type III effector YopM. Mbio. 5: e01402-14. PMID 24987096 DOI: 10.1128/mBio.01402-14  1
2014 Gagliani N, Palm NW, de Zoete MR, Flavell RA. Inflammasomes and intestinal homeostasis: regulating and connecting infection, inflammation and the microbiota. International Immunology. 26: 495-9. PMID 24948595 DOI: 10.1093/intimm/dxu066  1
2014 Sheppard NC, Brinckmann SA, Gartlan KH, Puthia M, Svanborg C, Krashias G, Eisenbarth SC, Flavell RA, Sattentau QJ, Wegmann F. Polyethyleneimine is a potent systemic adjuvant for glycoprotein antigens. International Immunology. 26: 531-8. PMID 24844701 DOI: 10.1093/intimm/dxu055  1
2014 Canaan A, DeFuria J, Perelman E, Schultz V, Seay M, Tuck D, Flavell RA, Snyder MP, Obin MS, Weissman SM. Extended lifespan and reduced adiposity in mice lacking the FAT10 gene. Proceedings of the National Academy of Sciences of the United States of America. 111: 5313-8. PMID 24706839 DOI: 10.1073/pnas.1323426111  1
2014 Wynosky-Dolfi MA, Snyder AG, Philip NH, Doonan PJ, Poffenberger MC, Avizonis D, Zwack EE, Riblett AM, Hu B, Strowig T, Flavell RA, Jones RG, Freedman BD, Brodsky IE. Oxidative metabolism enables Salmonella evasion of the NLRP3 inflammasome. The Journal of Experimental Medicine. 211: 653-68. PMID 24638169 DOI: 10.1084/jem.20130627  1
2014 Willinger T, Ferguson SM, Pereira JP, De Camilli P, Flavell RA. Dynamin 2-dependent endocytosis is required for sustained S1PR1 signaling. The Journal of Experimental Medicine. 211: 685-700. PMID 24638168 DOI: 10.1084/jem.20131343  1
2014 Kim LK, Esplugues E, Zorca CE, Parisi F, Kluger Y, Kim TH, Galjart NJ, Flavell RA. Oct-1 regulates IL-17 expression by directing interchromosomal associations in conjunction with CTCF in T cells. Molecular Cell. 54: 56-66. PMID 24613343 DOI: 10.1016/j.molcel.2014.02.004  1
2014 Wu X, Lahiri A, Haines GK, Flavell RA, Abraham C. NOD2 regulates CXCR3-dependent CD8+ T cell accumulation in intestinal tissues with acute injury. Journal of Immunology (Baltimore, Md. : 1950). 192: 3409-18. PMID 24591373 DOI: 10.4049/jimmunol.1302436  1
2014 Wlodarska M, Thaiss CA, Nowarski R, Henao-Mejia J, Zhang JP, Brown EM, Frankel G, Levy M, Katz MN, Philbrick WM, Elinav E, Finlay BB, Flavell RA. NLRP6 inflammasome orchestrates the colonic host-microbial interface by regulating goblet cell mucus secretion. Cell. 156: 1045-59. PMID 24581500 DOI: 10.1016/j.cell.2014.01.026  1
2014 Huang W, Kachapati K, Adams D, Wu Y, Leung PS, Yang GX, Zhang W, Ansari AA, Flavell RA, Gershwin ME, Ridgway WM. Murine autoimmune cholangitis requires two hits: cytotoxic KLRG1(+) CD8 effector cells and defective T regulatory cells. Journal of Autoimmunity. 50: 123-34. PMID 24556277 DOI: 10.1016/j.jaut.2014.01.034  0.32
2014 Hacisuleyman E, Goff LA, Trapnell C, Williams A, Henao-Mejia J, Sun L, McClanahan P, Hendrickson DG, Sauvageau M, Kelley DR, Morse M, Engreitz J, Lander ES, Guttman M, Lodish HF, ... Flavell R, et al. Topological organization of multichromosomal regions by the long intergenic noncoding RNA Firre. Nature Structural & Molecular Biology. 21: 198-206. PMID 24463464 DOI: 10.1038/nsmb.2764  1
2014 Henao-Mejia J, Elinav E, Thaiss CA, Flavell RA. Inflammasomes and metabolic disease. Annual Review of Physiology. 76: 57-78. PMID 24274736 DOI: 10.1146/annurev-physiol-021113-170324  1
2014 Liang X, Fu C, Cui W, Ober-Blöbaum JL, Zahner SP, Shrikant PA, Clausen BE, Flavell RA, Mellman I, Jiang A. β-catenin mediates tumor-induced immunosuppression by inhibiting cross-priming of CD8⁺ T cells. Journal of Leukocyte Biology. 95: 179-90. PMID 24023259 DOI: 10.1189/jlb.0613330  1
2013 Ouyang X, Ghani A, Malik A, Wilder T, Colegio OR, Flavell RA, Cronstein BN, Mehal WZ. Adenosine is required for sustained inflammasome activation via the Aâ‚‚A receptor and the HIF-1α pathway. Nature Communications. 4: 2909. PMID 24352507 DOI: 10.1038/ncomms3909  0.44
2013 Negishi H, Matsuki K, Endo N, Sarashina H, Miki S, Matsuda A, Fukazawa K, Taguchi-Atarashi N, Ikushima H, Yanai H, Nishio J, Honda K, Fujioka Y, Ohba Y, Noda T, ... ... Flavell RA, et al. Beneficial innate signaling interference for antibacterial responses by a Toll-like receptor-mediated enhancement of the MKP-IRF3 axis. Proceedings of the National Academy of Sciences of the United States of America. 110: 19884-9. PMID 24248350 DOI: 10.1073/pnas.1320145110  1
2013 Richter K, Perriard G, Behrendt R, Schwendener RA, Sexl V, Dunn R, Kamanaka M, Flavell RA, Roers A, Oxenius A. Macrophage and T cell produced IL-10 promotes viral chronicity. Plos Pathogens. 9: e1003735. PMID 24244162 DOI: 10.1371/journal.ppat.1003735  1
2013 Williams A, Henao-Mejia J, Harman CC, Flavell RA. miR-181 and metabolic regulation in the immune system. Cold Spring Harbor Symposia On Quantitative Biology. 78: 223-30. PMID 24163395 DOI: 10.1101/sqb.2013.78.020024  0.44
2013 Elinav E, Nowarski R, Thaiss CA, Hu B, Jin C, Flavell RA. Inflammation-induced cancer: crosstalk between tumours, immune cells and microorganisms. Nature Reviews. Cancer. 13: 759-71. PMID 24154716 DOI: 10.1038/nrc3611  1
2013 Henao-Mejia J, Elinav E, Thaiss CA, Licona-Limon P, Flavell RA. Role of the intestinal microbiome in liver disease. Journal of Autoimmunity. 46: 66-73. PMID 24075647 DOI: 10.1016/j.jaut.2013.07.001  1
2013 Chen X, Wen T, Wei J, Wu Z, Wang P, Hong Z, Zhao L, Wang B, Flavell R, Gao S, Wang M, Yin Z. Treatment of allergic inflammation and hyperresponsiveness by a simple compound, Bavachinin, isolated from Chinese herbs. Cellular & Molecular Immunology. 10: 497-505. PMID 24013845 DOI: 10.1038/cmi.2013.27  0.36
2013 Gisterå A, Robertson AK, Andersson J, Ketelhuth DF, Ovchinnikova O, Nilsson SK, Lundberg AM, Li MO, Flavell RA, Hansson GK. Transforming growth factor-β signaling in T cells promotes stabilization of atherosclerotic plaques through an interleukin-17-dependent pathway. Science Translational Medicine. 5: 196ra100. PMID 23903754 DOI: 10.1126/scitranslmed.3006133  1
2013 Geldhoff M, Mook-Kanamori BB, Brouwer MC, Troost D, Leemans JC, Flavell RA, Van der Ende A, Van der Poll T, Van de Beek D. Inflammasome activation mediates inflammation and outcome in humans and mice with pneumococcal meningitis. Bmc Infectious Diseases. 13: 358. PMID 23902681 DOI: 10.1186/1471-2334-13-358  1
2013 Elinav E, Thaiss CA, Flavell RA. Analysis of microbiota alterations in inflammasome-deficient mice. Methods in Molecular Biology (Clifton, N.J.). 1040: 185-94. PMID 23852605 DOI: 10.1007/978-1-62703-523-1_14  1
2013 Gagliani N, Jofra T, Valle A, Stabilini A, Morsiani C, Gregori S, Deng S, Rothstein DM, Atkinson M, Kamanaka M, Flavell RA, Roncarolo MG, Battaglia M. Transplant tolerance to pancreatic islets is initiated in the graft and sustained in the spleen. American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons. 13: 1963-75. PMID 23834659 DOI: 10.1111/ajt.12333  1
2013 Zhao Y, Zhao H, Sun Y, Hao J, Qi X, Zhou X, Wu Z, Wang P, Kaech SM, Weaver CT, Flavell RA, Zhao L, Yao Z, Yin Z. IL-4 induces a suppressive IL-10-producing CD8+ T cell population via a Cdkn2a-dependent mechanism. Journal of Leukocyte Biology. 94: 1103-12. PMID 23772040 DOI: 10.1189/jlb.0213064  1
2013 Casson CN, Copenhaver AM, Zwack EE, Nguyen HT, Strowig T, Javdan B, Bradley WP, Fung TC, Flavell RA, Brodsky IE, Shin S. Caspase-11 activation in response to bacterial secretion systems that access the host cytosol. Plos Pathogens. 9: e1003400. PMID 23762026 DOI: 10.1371/journal.ppat.1003400  1
2013 Lima-Junior DS, Costa DL, Carregaro V, Cunha LD, Silva AL, Mineo TW, Gutierrez FR, Bellio M, Bortoluci KR, Flavell RA, Bozza MT, Silva JS, Zamboni DS. Inflammasome-derived IL-1β production induces nitric oxide-mediated resistance to Leishmania. Nature Medicine. 19: 909-15. PMID 23749230 DOI: 10.1038/nm.3221  1
2013 Knauf F, Asplin JR, Granja I, Schmidt IM, Moeckel GW, David RJ, Flavell RA, Aronson PS. NALP3-mediated inflammation is a principal cause of progressive renal failure in oxalate nephropathy. Kidney International. 84: 895-901. PMID 23739234 DOI: 10.1038/ki.2013.207  1
2013 Hu B, Elinav E, Huber S, Strowig T, Hao L, Hafemann A, Jin C, Wunderlich C, Wunderlich T, Eisenbarth SC, Flavell RA. Microbiota-induced activation of epithelial IL-6 signaling links inflammasome-driven inflammation with transmissible cancer. Proceedings of the National Academy of Sciences of the United States of America. 110: 9862-7. PMID 23696660 DOI: 10.1073/pnas.1307575110  0.44
2013 Licona-Limón P, Kim LK, Palm NW, Flavell RA. TH2, allergy and group 2 innate lymphoid cells. Nature Immunology. 14: 536-42. PMID 23685824 DOI: 10.1038/ni.2617  1
2013 Henao-Mejia J, Williams A, Goff LA, Staron M, Licona-Limón P, Kaech SM, Nakayama M, Rinn JL, Flavell RA. The microRNA miR-181 is a critical cellular metabolic rheostat essential for NKT cell ontogenesis and lymphocyte development and homeostasis. Immunity. 38: 984-97. PMID 23623381 DOI: 10.1016/j.immuni.2013.02.021  1
2013 Henao-Mejia J, Elinav E, Thaiss CA, Flavell RA. The intestinal microbiota in chronic liver disease. Advances in Immunology. 117: 73-97. PMID 23611286 DOI: 10.1016/B978-0-12-410524-9.00003-7  1
2013 Zenewicz LA, Yin X, Wang G, Elinav E, Hao L, Zhao L, Flavell RA. IL-22 deficiency alters colonic microbiota to be transmissible and colitogenic. Journal of Immunology (Baltimore, Md. : 1950). 190: 5306-12. PMID 23585682 DOI: 10.4049/jimmunol.1300016  0.6
2013 Williams A, Lee GR, Spilianakis CG, Hwang SS, Eisenbarth SC, Flavell RA. Hypersensitive site 6 of the Th2 locus control region is essential for Th2 cytokine expression. Proceedings of the National Academy of Sciences of the United States of America. 110: 6955-60. PMID 23569250 DOI: 10.1073/pnas.1304720110  0.76
2013 Ishigame H, Zenewicz LA, Sanjabi S, Licona-Limón P, Nakayama M, Leonard WJ, Flavell RA. Excessive Th1 responses due to the absence of TGF-β signaling cause autoimmune diabetes and dysregulated Treg cell homeostasis. Proceedings of the National Academy of Sciences of the United States of America. 110: 6961-6. PMID 23569233 DOI: 10.1073/pnas.1304498110  0.6
2013 Lawrence TM, Hudacek AW, de Zoete MR, Flavell RA, Schnell MJ. Rabies virus is recognized by the NLRP3 inflammasome and activates interleukin-1β release in murine dendritic cells. Journal of Virology. 87: 5848-57. PMID 23487464 DOI: 10.1128/JVI.00203-13  1
2013 Wang Y, Hu Y, Chao C, Yuksel M, Colle I, Flavell RA, Ma Y, Yan H, Wen L. Role of IRAK-M in alcohol induced liver injury. Plos One. 8: e57085. PMID 23437317 DOI: 10.1371/journal.pone.0057085  0.36
2013 Ye J, Llorian M, Cardona M, Rongvaux A, Moubarak RS, Comella JX, Bassel-Duby R, Flavell RA, Olson EN, Smith CW, Sanchis D. A pathway involving HDAC5, cFLIP and caspases regulates expression of the splicing regulator polypyrimidine tract binding protein in the heart. Journal of Cell Science. 126: 1682-91. PMID 23424201 DOI: 10.1242/jcs.121384  1
2013 Martin RA, Ather JL, Lundblad LK, Suratt BT, Boyson JE, Budd RC, Alcorn JF, Flavell RA, Eisenbarth SC, Poynter ME. Interleukin-1 receptor and caspase-1 are required for the Th17 response in nitrogen dioxide-promoted allergic airway disease. American Journal of Respiratory Cell and Molecular Biology. 48: 655-64. PMID 23371061 DOI: 10.1165/rcmb.2012-0423OC  1
2013 Rongvaux A, Takizawa H, Strowig T, Willinger T, Eynon EE, Flavell RA, Manz MG. Human hemato-lymphoid system mice: current use and future potential for medicine. Annual Review of Immunology. 31: 635-74. PMID 23330956 DOI: 10.1146/annurev-immunol-032712-095921  0.4
2013 Chaiyachati BH, Jani A, Wan Y, Huang H, Flavell R, Chi T. BRG1-mediated immune tolerance: facilitation of Treg activation and partial independence of chromatin remodelling. The Embo Journal. 32: 395-408. PMID 23321680 DOI: 10.1038/emboj.2012.350  1
2013 Case CL, Kohler LJ, Lima JB, Strowig T, de Zoete MR, Flavell RA, Zamboni DS, Roy CR. Caspase-11 stimulates rapid flagellin-independent pyroptosis in response to Legionella pneumophila. Proceedings of the National Academy of Sciences of the United States of America. 110: 1851-6. PMID 23307811 DOI: 10.1073/pnas.1211521110  1
2013 Terwagne M, Ferooz J, Rolán HG, Sun YH, Atluri V, Xavier MN, Franchi L, Núñez G, Legrand T, Flavell RA, De Bolle X, Letesson JJ, Tsolis RM. Innate immune recognition of flagellin limits systemic persistence of Brucella. Cellular Microbiology. 15: 942-60. PMID 23227931 DOI: 10.1111/cmi.12088  1
2013 Han MS, Jung DY, Morel C, Lakhani SA, Kim JK, Flavell RA, Davis RJ. JNK expression by macrophages promotes obesity-induced insulin resistance and inflammation. Science (New York, N.Y.). 339: 218-22. PMID 23223452 DOI: 10.1126/science.1227568  1
2013 McGee HM, Schmidt BA, Booth CJ, Yancopoulos GD, Valenzuela DM, Murphy AJ, Stevens S, Flavell RA, Horsley V. IL-22 promotes fibroblast-mediated wound repair in the skin. The Journal of Investigative Dermatology. 133: 1321-9. PMID 23223145 DOI: 10.1038/jid.2012.463  1
2013 Chaiyachati BH, Kaundal RK, Zhao J, Wu J, Flavell R, Chi T. LoxP-FRT Trap (LOFT): a simple and flexible system for conventional and reversible gene targeting. Bmc Biology. 10: 96. PMID 23198860 DOI: 10.1186/1741-7007-10-96  1
2013 Lievens D, Habets KL, Robertson AK, Laouar Y, Winkels H, Rademakers T, Beckers L, Wijnands E, Boon L, Mosaheb M, Ait-Oufella H, Mallat Z, Flavell RA, Rudling M, Binder CJ, et al. Abrogated transforming growth factor beta receptor II (TGFβRII) signalling in dendritic cells promotes immune reactivity of T cells resulting in enhanced atherosclerosis European Heart Journal. 34: 3717-3727. PMID 22613345 DOI: 10.1093/eurheartj/ehs106  1
2012 Huber S, Gagliani N, Zenewicz LA, Huber FJ, Bosurgi L, Hu B, Hedl M, Zhang W, O'Connor W, Murphy AJ, Valenzuela DM, Yancopoulos GD, Booth CJ, Cho JH, Ouyang W, ... ... Flavell RA, et al. IL-22BP is regulated by the inflammasome and modulates tumorigenesis in the intestine. Nature. 491: 259-63. PMID 23075849 DOI: 10.1038/nature11535  1
2012 Joly S, Eisenbarth SC, Olivier AK, Williams A, Kaplan DH, Cassel SL, Flavell RA, Sutterwala FS. Cutting edge: Nlrp10 is essential for protective antifungal adaptive immunity against Candida albicans. Journal of Immunology (Baltimore, Md. : 1950). 189: 4713-7. PMID 23071280 DOI: 10.4049/jimmunol.1201715  0.44
2012 Hoshi N, Schenten D, Nish SA, Walther Z, Gagliani N, Flavell RA, Reizis B, Shen Z, Fox JG, Iwasaki A, Medzhitov R. MyD88 signalling in colonic mononuclear phagocytes drives colitis in IL-10-deficient mice. Nature Communications. 3: 1120. PMID 23047678 DOI: 10.1038/ncomms2113  1
2012 Liu X, Yan X, Zhong B, Nurieva RI, Wang A, Wang X, Martin-Orozco N, Wang Y, Chang SH, Esplugues E, Flavell RA, Tian Q, Dong C. Bcl6 expression specifies the T follicular helper cell program in vivo. The Journal of Experimental Medicine. 209: 1841-52, S1-24. PMID 22987803 DOI: 10.1084/jem.20120219  1
2012 Wang P, Bai F, Zenewicz LA, Dai J, Gate D, Cheng G, Yang L, Qian F, Yuan X, Montgomery RR, Flavell RA, Town T, Fikrig E. IL-22 signaling contributes to West Nile encephalitis pathogenesis. Plos One. 7: e44153. PMID 22952908 DOI: 10.1371/journal.pone.0044153  1
2012 Wegmann F, Gartlan KH, Harandi AM, Brinckmann SA, Coccia M, Hillson WR, Kok WL, Cole S, Ho LP, Lambe T, Puthia M, Svanborg C, Scherer EM, Krashias G, Williams A, ... ... Flavell RA, et al. Polyethyleneimine is a potent mucosal adjuvant for viral glycoprotein antigens. Nature Biotechnology. 30: 883-8. PMID 22922673 DOI: 10.1038/nbt.2344  1
2012 Gaddi PJ, Crane MJ, Kamanaka M, Flavell RA, Yap GS, Salazar-Mather TP. IL-10 mediated regulation of liver inflammation during acute murine cytomegalovirus infection. Plos One. 7: e42850. PMID 22880122 DOI: 10.1371/journal.pone.0042850  1
2012 Mandaric S, Walton SM, Rülicke T, Richter K, Girard-Madoux MJ, Clausen BE, Zurunic A, Kamanaka M, Flavell RA, Jonjic S, Oxenius A. IL-10 suppression of NK/DC crosstalk leads to poor priming of MCMV-specific CD4 T cells and prolonged MCMV persistence. Plos Pathogens. 8: e1002846. PMID 22876184 DOI: 10.1371/journal.ppat.1002846  1
2012 Dela Cruz CS, Liu W, He CH, Jacoby A, Gornitzky A, Ma B, Flavell R, Lee CG, Elias JA. Chitinase 3-like-1 promotes Streptococcus pneumoniae killing and augments host tolerance to lung antibacterial responses. Cell Host & Microbe. 12: 34-46. PMID 22817986 DOI: 10.1016/j.chom.2012.05.017  1
2012 Park J, Wrzesinski SH, Stern E, Look M, Criscione J, Ragheb R, Jay SM, Demento SL, Agawu A, Licona Limon P, Ferrandino AF, Gonzalez D, Habermann A, Flavell RA, Fahmy TM. Combination delivery of TGF-β inhibitor and IL-2 by nanoscale liposomal polymeric gels enhances tumour immunotherapy. Nature Materials. 11: 895-905. PMID 22797827 DOI: 10.1038/nmat3355  1
2012 Hübner A, Mulholland DJ, Standen CL, Karasarides M, Cavanagh-Kyros J, Barrett T, Chi H, Greiner DL, Tournier C, Sawyers CL, Flavell RA, Wu H, Davis RJ. JNK and PTEN cooperatively control the development of invasive adenocarcinoma of the prostate. Proceedings of the National Academy of Sciences of the United States of America. 109: 12046-51. PMID 22753496 DOI: 10.1073/pnas.1209660109  0.64
2012 Sukumaran B, Ogura Y, Pedra JH, Kobayashi KS, Flavell RA, Fikrig E. Receptor interacting protein-2 contributes to host defense against Anaplasma phagocytophilum infection. Fems Immunology and Medical Microbiology. 66: 211-9. PMID 22747758 DOI: 10.1111/j.1574-695X.2012.01001.x  1
2012 Hoogerwerf JJ, van der Windt GJ, Blok DC, Hoogendijk AJ, De Vos AF, van 't Veer C, Florquin S, Kobayashi KS, Flavell RA, van der Poll T. Interleukin-1 receptor-associated kinase M-deficient mice demonstrate an improved host defense during Gram-negative pneumonia. Molecular Medicine (Cambridge, Mass.). 18: 1067-75. PMID 22729155 DOI: 10.2119/molmed.2011.00450  1
2012 Zhang W, Ferguson J, Ng SM, Hui K, Goh G, Lin A, Esplugues E, Flavell RA, Abraham C, Zhao H, Cho JH. Effector CD4+ T cell expression signatures and immune-mediated disease associated genes. Plos One. 7: e38510. PMID 22715389 DOI: 10.1371/journal.pone.0038510  0.32
2012 Walsh KB, Teijaro JR, Zuniga EI, Welch MJ, Fremgen DM, Blackburn SD, von Tiehl KF, Wherry EJ, Flavell RA, Oldstone MB. Toll-like receptor 7 is required for effective adaptive immune responses that prevent persistent virus infection. Cell Host & Microbe. 11: 643-53. PMID 22704624 DOI: 10.1016/j.chom.2012.04.016  1
2012 Bobr A, Igyarto BZ, Haley KM, Li MO, Flavell RA, Kaplan DH. Autocrine/paracrine TGF-β1 inhibits Langerhans cell migration Proceedings of the National Academy of Sciences of the United States of America. 109: 10492-10497. PMID 22689996 DOI: 10.1073/pnas.1119178109  1
2012 Ballinger MN, Newstead MW, Zeng X, Bhan U, Horowitz JC, Moore BB, Pinsky DJ, Flavell RA, Standiford TJ. TLR signaling prevents hyperoxia-induced lung injury by protecting the alveolar epithelium from oxidant-mediated death. Journal of Immunology (Baltimore, Md. : 1950). 189: 356-64. PMID 22661086 DOI: 10.4049/jimmunol.1103124  1
2012 Helbig C, Gentek R, Backer RA, de Souza Y, Derks IA, Eldering E, Wagner K, Jankovic D, Gridley T, Moerland PD, Flavell RA, Amsen D. Notch controls the magnitude of T helper cell responses by promoting cellular longevity. Proceedings of the National Academy of Sciences of the United States of America. 109: 9041-6. PMID 22615412 DOI: 10.1073/pnas.1206044109  1
2012 Wu LH, Huang CC, Adhikarakunnathu S, San Mateo LR, Duffy KE, Rafferty P, Bugelski P, Raymond H, Deutsch H, Picha K, Ward CK, Alexoupolou L, Flavell RA, Mbow ML, Susulic VS. Loss of toll-like receptor 3 function improves glucose tolerance and reduces liver steatosis in obese mice. Metabolism: Clinical and Experimental. 61: 1633-45. PMID 22607770 DOI: 10.1016/j.metabol.2012.04.015  1
2012 Czyzyk J, Henegariu O, Preston-Hurlburt P, Baldzizhar R, Fedorchuk C, Esplugues E, Bottomly K, Gorus FK, Herold K, Flavell RA. Enhanced anti-serpin antibody activity inhibits autoimmune inflammation in type 1 diabetes. Journal of Immunology (Baltimore, Md. : 1950). 188: 6319-27. PMID 22593614 DOI: 10.4049/jimmunol.1200467  1
2012 Eisenbarth SC, Williams A, Colegio OR, Meng H, Strowig T, Rongvaux A, Henao-Mejia J, Thaiss CA, Joly S, Gonzalez DG, Xu L, Zenewicz LA, Haberman AM, Elinav E, Kleinstein SH, ... ... Flavell RA, et al. NLRP10 is a NOD-like receptor essential to initiate adaptive immunity by dendritic cells. Nature. 484: 510-3. PMID 22538615 DOI: 10.1038/nature11012  1
2012 Kuipers MT, Aslami H, Janczy JR, Van Der Sluijs KF, Vlaar APJ, Wolthuis EK, Choi G, Roelofs JJTH, Flavell RA, Sutterwala FS, Bresser P, Leemans JC, Van Der Poll T, Schultz MJ, Wieland CW. Ventilator-induced lung injury is mediated by the NLRP3 inflammasome Anesthesiology. 116: 1104-1115. PMID 22531249 DOI: 10.1097/ALN.0b013e3182518bc0  1
2012 van der Windt GJ, Blok DC, Hoogerwerf JJ, Lammers AJ, de Vos AF, Van't Veer C, Florquin S, Kobayashi KS, Flavell RA, van der Poll T. Interleukin 1 receptor-associated kinase m impairs host defense during pneumococcal pneumonia. The Journal of Infectious Diseases. 205: 1849-57. PMID 22492852 DOI: 10.1093/infdis/jis290  1
2012 Henao-Mejia J, Elinav E, Jin C, Hao L, Mehal WZ, Strowig T, Thaiss CA, Kau AL, Eisenbarth SC, Jurczak MJ, Camporez JP, Shulman GI, Gordon JI, Hoffman HM, Flavell RA. Inflammasome-mediated dysbiosis regulates progression of NAFLD and obesity. Nature. 482: 179-85. PMID 22297845 DOI: 10.1038/nature10809  1
2012 Waldron-Lynch F, Henegariu O, Deng S, Preston-Hurlburt P, Tooley J, Flavell R, Herold KC. Teplizumab induces human gut-tropic regulatory cells in humanized mice and patients. Science Translational Medicine. 4: 118ra12. PMID 22277969 DOI: 10.1126/scitranslmed.3003401  1
2012 Koduru S, Wong E, Strowig T, Sundaram R, Zhang L, Strout MP, Flavell RA, Schatz DG, Dhodapkar KM, Dhodapkar MV. Dendritic cell-mediated activation-induced cytidine deaminase (AID)-dependent induction of genomic instability in human myeloma. Blood. 119: 2302-9. PMID 22234692 DOI: 10.1182/blood-2011-08-376236  1
2011 Tao J, Kamanaka M, Hao J, Hao Z, Jiang X, Craft JE, Flavell RA, Wu Z, Hong Z, Zhao L, Yin Z. IL-10 signaling in CD4+ T cells is critical for the pathogenesis of collagen-induced arthritis. Arthritis Research & Therapy. 13: R212. PMID 22192790 DOI: 10.1186/ar3545  1
2011 Malik AF, Hoque R, Ouyang X, Ghani A, Hong E, Khan K, Moore LB, Ng G, Munro F, Flavell RA, Shi Y, Kyriakides TR, Mehal WZ. Inflammasome components Asc and caspase-1 mediate biomaterial-induced inflammation and foreign body response. Proceedings of the National Academy of Sciences of the United States of America. 108: 20095-100. PMID 22109549 DOI: 10.1073/pnas.1105152108  1
2011 Ahmed N, Zeng M, Sinha I, Polin L, Wei WZ, Rathinam C, Flavell R, Massoumi R, Venuprasad K. The E3 ligase Itch and deubiquitinase Cyld act together to regulate Tak1 and inflammation. Nature Immunology. 12: 1176-83. PMID 22057290 DOI: 10.1038/ni.2157  1
2011 Kant S, Swat W, Zhang S, Zhang ZY, Neel BG, Flavell RA, Davis RJ. TNF-stimulated MAP kinase activation mediated by a Rho family GTPase signaling pathway. Genes & Development. 25: 2069-78. PMID 21979919 DOI: 10.1101/gad.17224711  1
2011 Allen SJ, Mott KR, Wechsler SL, Flavell RA, Town T, Ghiasi H. Adaptive and innate transforming growth factor beta signaling impact herpes simplex virus 1 latency and reactivation. Journal of Virology. 85: 11448-56. PMID 21880769 DOI: 10.1128/JVI.00678-11  1
2011 Balamayooran T, Batra S, Balamayooran G, Cai S, Kobayashi KS, Flavell RA, Jeyaseelan S. Receptor-interacting protein 2 controls pulmonary host defense to Escherichia coli infection via the regulation of interleukin-17A. Infection and Immunity. 79: 4588-99. PMID 21844230 DOI: 10.1128/IAI.05641-11  1
2011 Rathinam C, Poueymirou WT, Rojas J, Murphy AJ, Valenzuela DM, Yancopoulos GD, Rongvaux A, Eynon EE, Manz MG, Flavell RA. Efficient differentiation and function of human macrophages in humanized CSF-1 mice. Blood. 118: 3119-28. PMID 21791433 DOI: 10.1182/blood-2010-12-326926  1
2011 Esplugues E, Huber S, Gagliani N, Hauser AE, Town T, Wan YY, O'Connor W, Rongvaux A, Van Rooijen N, Haberman AM, Iwakura Y, Kuchroo VK, Kolls JK, Bluestone JA, Herold KC, ... Flavell RA, et al. Control of TH17 cells occurs in the small intestine. Nature. 475: 514-8. PMID 21765430 DOI: 10.1038/nature10228  1
2011 Elinav E, Strowig T, Kau AL, Henao-Mejia J, Thaiss CA, Booth CJ, Peaper DR, Bertin J, Eisenbarth SC, Gordon JI, Flavell RA. NLRP6 inflammasome regulates colonic microbial ecology and risk for colitis. Cell. 145: 745-57. PMID 21565393 DOI: 10.1016/j.cell.2011.04.022  1
2011 Kamanaka M, Huber S, Zenewicz LA, Gagliani N, Rathinam C, O'Connor W, Wan YY, Nakae S, Iwakura Y, Hao L, Flavell RA. Memory/effector (CD45RB(lo)) CD4 T cells are controlled directly by IL-10 and cause IL-22-dependent intestinal pathology. The Journal of Experimental Medicine. 208: 1027-40. PMID 21518800 DOI: 10.1084/jem.20102149  0.6
2011 Wen L, Green EA, Stratmann T, Panosa A, Gomis R, Eynon EE, Flavell RA, Mezquita JA, Mora C. In vivo diabetogenic action of CD4+ T lymphocytes requires Fas expression and is independent of IL-1 and IL-18. European Journal of Immunology. 41: 1344-51. PMID 21469125 DOI: 10.1002/eji.201041216  1
2011 Weisser SB, McLarren KW, Voglmaier N, van Netten-Thomas CJ, Antov A, Flavell RA, Sly LM. Alternative activation of macrophages by IL-4 requires SHIP degradation. European Journal of Immunology. 41: 1742-53. PMID 21469115 DOI: 10.1002/eji.201041105  0.72
2011 Carter NA, Vasconcellos R, Rosser EC, Tulone C, Muñoz-Suano A, Kamanaka M, Ehrenstein MR, Flavell RA, Mauri C. Mice lacking endogenous IL-10-producing regulatory B cells develop exacerbated disease and present with an increased frequency of Th1/Th17 but a decrease in regulatory T cells Journal of Immunology. 186: 5569-5579. PMID 21464089 DOI: 10.4049/jimmunol.1100284  1
2011 Gutcher I, Donkor MK, Ma Q, Rudensky AY, Flavell RA, Li MO. Autocrine transforming growth factor-β1 promotes in vivo Th17 cell differentiation. Immunity. 34: 396-408. PMID 21435587 DOI: 10.1016/j.immuni.2011.03.005  0.44
2011 Nel HJ, Hams E, Saunders SP, Mangan NE, Smith P, Atzberger A, Flavell RA, Akira S, McKenzie AN, Fallon PG. Impaired basophil induction leads to an age-dependent innate defect in type 2 immunity during helminth infection in mice. Journal of Immunology (Baltimore, Md. : 1950). 186: 4631-9. PMID 21398616 DOI: 10.4049/jimmunol.1002995  1
2011 Kreuzaler PA, Staniszewska AD, Li W, Omidvar N, Kedjouar B, Turkson J, Poli V, Flavell RA, Clarkson RW, Watson CJ. Stat3 controls lysosomal-mediated cell death in vivo. Nature Cell Biology. 13: 303-9. PMID 21336304 DOI: 10.1038/ncb2171  1
2011 Liu W, Zi M, Chi H, Jin J, Prehar S, Neyses L, Cartwright EJ, Flavell RA, Davis RJ, Wang X. Deprivation of MKK7 in cardiomyocytes provokes heart failure in mice when exposed to pressure overload. Journal of Molecular and Cellular Cardiology. 50: 702-11. PMID 21284947 DOI: 10.1016/j.yjmcc.2011.01.013  0.64
2011 Rongvaux A, Willinger T, Takizawa H, Rathinam C, Auerbach W, Murphy AJ, Valenzuela DM, Yancopoulos GD, Eynon EE, Stevens S, Manz MG, Flavell RA. Human thrombopoietin knockin mice efficiently support human hematopoiesis in vivo. Proceedings of the National Academy of Sciences of the United States of America. 108: 2378-83. PMID 21262827 DOI: 10.1073/pnas.1019524108  1
2011 Willinger T, Rongvaux A, Takizawa H, Yancopoulos GD, Valenzuela DM, Murphy AJ, Auerbach W, Eynon EE, Stevens S, Manz MG, Flavell RA. Human IL-3/GM-CSF knock-in mice support human alveolar macrophage development and human immune responses in the lung. Proceedings of the National Academy of Sciences of the United States of America. 108: 2390-5. PMID 21262803 DOI: 10.1073/pnas.1019682108  1
2011 Mott KR, Gate D, Zandian M, Allen SJ, Rajasagi NK, van Rooijen N, Chen S, Arditi M, Rouse BT, Flavell RA, Town T, Ghiasi H. Macrophage IL-12p70 signaling prevents HSV-1-induced CNS autoimmunity triggered by autoaggressive CD4+ Tregs. Investigative Ophthalmology & Visual Science. 52: 2321-33. PMID 21220560 DOI: 10.1167/iovs.10-6536  1
2011 Cole JE, Navin TJ, Cross AJ, Goddard ME, Alexopoulou L, Mitra AT, Davies AH, Flavell RA, Feldmann M, Monaco C. Unexpected protective role for Toll-like receptor 3 in the arterial wall. Proceedings of the National Academy of Sciences of the United States of America. 108: 2372-7. PMID 21220319 DOI: 10.1073/pnas.1018515108  1
2011 Sun X, Wu Y, Chen B, Zhang Z, Zhou W, Tong Y, Yuan J, Xia K, Gronemeyer H, Flavell RA, Song W. Regulator of calcineurin 1 (RCAN1) facilitates neuronal apoptosis through caspase-3 activation. The Journal of Biological Chemistry. 286: 9049-62. PMID 21216952 DOI: 10.1074/jbc.M110.177519  0.32
2011 Wu Y, Xu J, Velazquez H, Wang P, Li G, Liu D, Sampaio-Maia B, Quelhas-Santos J, Russell K, Russell R, Flavell RA, Pestana M, Giordano F, Desir GV. Renalase deficiency aggravates ischemic myocardial damage. Kidney International. 79: 853-60. PMID 21178975 DOI: 10.1038/ki.2010.488  1
2011 Bunting RA, Duffy KE, Lamb RJ, San Mateo LR, Smalley K, Raymond H, Liu X, Petley T, Fisher J, Beck H, Flavell RA, Alexopoulou L, Ward CK. Novel antagonist antibody to TLR3 blocks poly(I:C)-induced inflammation in vivo and in vitro. Cellular Immunology. 267: 9-16. PMID 21092943 DOI: 10.1016/j.cellimm.2010.10.008  1
2010 Hu B, Elinav E, Huber S, Booth CJ, Strowig T, Jin C, Eisenbarth SC, Flavell RA. Inflammation-induced tumorigenesis in the colon is regulated by caspase-1 and NLRC4. Proceedings of the National Academy of Sciences of the United States of America. 107: 21635-40. PMID 21118981 DOI: 10.1073/pnas.1016814108  0.44
2010 Song J, Willinger T, Rongvaux A, Eynon EE, Stevens S, Manz MG, Flavell RA, Galán JE. A mouse model for the human pathogen Salmonella typhi. Cell Host & Microbe. 8: 369-76. PMID 20951970 DOI: 10.1016/j.chom.2010.09.003  0.4
2010 Wang Y, Souabni A, Flavell RA, Wan YY. An intrinsic mechanism predisposes Foxp3-expressing regulatory T cells to Th2 conversion in vivo. Journal of Immunology (Baltimore, Md. : 1950). 185: 5983-92. PMID 20944002 DOI: 10.4049/jimmunol.1001255  0.4
2010 Chi H, Flavell RA. Studies on MAP Kinase signaling in the immune system. Methods in Molecular Biology (Clifton, N.J.). 661: 471-80. PMID 20812002 DOI: 10.1007/978-1-60761-795-2_29  1
2010 Demaria O, Pagni PP, Traub S, de Gassart A, Branzk N, Murphy AJ, Valenzuela DM, Yancopoulos GD, Flavell RA, Alexopoulou L. TLR8 deficiency leads to autoimmunity in mice. The Journal of Clinical Investigation. 120: 3651-62. PMID 20811154 DOI: 10.1172/JCI42081  1
2010 Hawiger D, Wan YY, Eynon EE, Flavell RA. The transcription cofactor Hopx is required for regulatory T cell function in dendritic cell-mediated peripheral T cell unresponsiveness. Nature Immunology. 11: 962-8. PMID 20802482 DOI: 10.1038/ni.1929  0.4
2010 Huber S, Flavell RA. Checks and balances: IL-23 in the intestine. Immunity. 33: 150-2. PMID 20732638 DOI: 10.1016/j.immuni.2010.08.005  1
2010 Frutuoso MS, Hori JI, Pereira MSF, Junior DSL, Sônego F, Kobayashi KS, Flavell RA, Cunha FQ, Zamboni DS. The pattern recognition receptors Nod1 and Nod2 account for neutrophil recruitment to the lungs of mice infected with Legionella pneumophila Microbes and Infection. 12: 819-827. PMID 20685341 DOI: 10.1016/j.micinf.2010.05.006  1
2010 Morel C, Standen CL, Jung DY, Gray S, Ong H, Flavell RA, Kim JK, Davis RJ. Requirement of JIP1-mediated c-Jun N-terminal kinase activation for obesity-induced insulin resistance. Molecular and Cellular Biology. 30: 4616-25. PMID 20679483 DOI: 10.1128/MCB.00585-10  0.48
2010 Koh BH, Hwang SS, Kim JY, Lee W, Kang MJ, Lee CG, Park JW, Flavell RA, Lee GR. Th2 LCR is essential for regulation of Th2 cytokine genes and for pathogenesis of allergic asthma. Proceedings of the National Academy of Sciences of the United States of America. 107: 10614-9. PMID 20483988 DOI: 10.1073/pnas.1005383107  0.76
2010 Brodsky IE, Palm NW, Sadanand S, Ryndak MB, Sutterwala FS, Flavell RA, Bliska JB, Medzhitov R. A Yersinia effector protein promotes virulence by preventing inflammasome recognition of the type III secretion system. Cell Host & Microbe. 7: 376-87. PMID 20478539 DOI: 10.1016/j.chom.2010.04.009  1
2010 Hubbard LL, Ballinger MN, Thomas PE, Wilke CA, Standiford TJ, Kobayashi KS, Flavell RA, Moore BB. A role for IL-1 receptor-associated kinase-M in prostaglandin E2-induced immunosuppression post-bone marrow transplantation. Journal of Immunology (Baltimore, Md. : 1950). 184: 6299-308. PMID 20439918 DOI: 10.4049/jimmunol.0902828  1
2010 Choi WS, Abel G, Klintworth H, Flavell RA, Xia Z. JNK3 mediates paraquat- and rotenone-induced dopaminergic neuron death. Journal of Neuropathology and Experimental Neurology. 69: 511-20. PMID 20418776 DOI: 10.1097/NEN.0b013e3181db8100  1
2010 Yamamoto Y, Moore R, Flavell RA, Lu B, Negishi M. Nuclear receptor CAR represses TNFalpha-induced cell death by interacting with the anti-apoptotic GADD45B. Plos One. 5: e10121. PMID 20404936 DOI: 10.1371/journal.pone.0010121  1
2010 Ktistaki E, Garefalaki A, Williams A, Andrews SR, Bell DM, Foster KE, Spilianakis CG, Flavell RA, Kosyakova N, Trifonov V, Liehr T, Kioussis D. CD8 locus nuclear dynamics during thymocyte development. Journal of Immunology (Baltimore, Md. : 1950). 184: 5686-95. PMID 20404270 DOI: 10.4049/jimmunol.1000170  1
2010 Archer KA, Ader F, Kobayashi KS, Flavell RA, Roy CR. Cooperation between multiple microbial pattern recognition systems is important for host protection against the intracellular pathogen Legionella pneumophila. Infection and Immunity. 78: 2477-87. PMID 20351139 DOI: 10.1128/IAI.00243-10  1
2010 Zenewicz LA, Abraham C, Flavell RA, Cho JH. Unraveling the genetics of autoimmunity. Cell. 140: 791-7. PMID 20303870 DOI: 10.1016/j.cell.2010.03.003  0.6
2010 Williams A, Spilianakis CG, Flavell RA. Interchromosomal association and gene regulation in trans. Trends in Genetics : Tig. 26: 188-97. PMID 20236724 DOI: 10.1016/j.tig.2010.01.007  0.48
2010 Mayer-Barber KD, Barber DL, Shenderov K, White SD, Wilson MS, Cheever A, Kugler D, Hieny S, Caspar P, Núñez G, Schlueter D, Flavell RA, Sutterwala FS, Sher A. Caspase-1 independent IL-1beta production is critical for host resistance to mycobacterium tuberculosis and does not require TLR signaling in vivo. Journal of Immunology (Baltimore, Md. : 1950). 184: 3326-30. PMID 20200276 DOI: 10.4049/jimmunol.0904189  1
2010 Williams A, Flavell RA, Eisenbarth SC. The role of NOD-like Receptors in shaping adaptive immunity. Current Opinion in Immunology. 22: 34-40. PMID 20149616 DOI: 10.1016/j.coi.2010.01.004  0.44
2010 Kinnebrew MA, Ubeda C, Zenewicz LA, Smith N, Flavell RA, Pamer EG. Bacterial flagellin stimulates Toll-like receptor 5-dependent defense against vancomycin-resistant Enterococcus infection. The Journal of Infectious Diseases. 201: 534-43. PMID 20064069 DOI: 10.1086/650203  1
2010 Silva GK, Gutierrez FRS, Guedes PMM, Horta CV, Cunha LD, Mineo TWP, Santiago-Silva J, Kobayashi KS, Flavell RA, Silva JS, Zamboni DS. Cutting edge: Nucleotide-binding oligomerization domain 1-dependent responses account for murine resistance against Trypanosoma cruzi infection Journal of Immunology. 184: 1148-1152. PMID 20042586 DOI: 10.4049/jimmunol.0902254  1
2010 Lee WW, Kang SW, Choi J, Lee SH, Shah K, Eynon EE, Flavell RA, Kang I. Regulating human Th17 cells via differential expression of IL-1 receptor Blood. 115: 530-540. PMID 19965648 DOI: 10.1182/blood-2009-08-236521  1
2010 Hübner A, Cavanagh-Kyros J, Rincon M, Flavell RA, Davis RJ. Functional cooperation of the proapoptotic Bcl2 family proteins Bmf and Bim in vivo. Molecular and Cellular Biology. 30: 98-105. PMID 19841067 DOI: 10.1128/MCB.01155-09  0.48
2009 Iyer SS, Pulskens WP, Sadler JJ, Butter LM, Teske GJ, Ulland TK, Eisenbarth SC, Florquin S, Flavell RA, Leemans JC, Sutterwala FS. Necrotic cells trigger a sterile inflammatory response through the Nlrp3 inflammasome. Proceedings of the National Academy of Sciences of the United States of America. 106: 20388-93. PMID 19918053 DOI: 10.1073/pnas.0908698106  1
2009 Bai F, Town T, Qian F, Wang P, Kamanaka M, Connolly TM, Gate D, Montgomery RR, Flavell RA, Fikrig E. IL-10 signaling blockade controls murine West Nile virus infection. Plos Pathogens. 5: e1000610. PMID 19816558 DOI: 10.1371/journal.ppat.1000610  1
2009 Bogani D, Siggers P, Brixey R, Warr N, Beddow S, Edwards J, Williams D, Wilhelm D, Koopman P, Flavell RA, Chi H, Ostrer H, Wells S, Cheeseman M, Greenfield A. Loss of mitogen-activated protein kinase kinase kinase 4 (MAP3K4) reveals a requirement for MAPK signalling in mouse sex determination. Plos Biology. 7: e1000196. PMID 19753101 DOI: 10.1371/journal.pbio.1000196  1
2009 Bhowmick S, Singh A, Flavell RA, Clark RB, O'Rourke J, Cone RE. The sympathetic nervous system modulates CD4(+)FoxP3(+) regulatory T cells via a TGF-beta-dependent mechanism. Journal of Leukocyte Biology. 86: 1275-83. PMID 19741161 DOI: 10.1189/jlb.0209107  1
2009 Marks BR, Nowyhed HN, Choi JY, Poholek AC, Odegard JM, Flavell RA, Craft J. Thymic self-reactivity selects natural interleukin 17-producing T cells that can regulate peripheral inflammation. Nature Immunology. 10: 1125-32. PMID 19734905 DOI: 10.1038/ni.1783  1
2009 Kuroda E, Ho V, Ruschmann J, Antignano F, Hamilton M, Rauh MJ, Antov A, Flavell RA, Sly LM, Krystal G. SHIP represses the generation of IL-3-induced M2 macrophages by inhibiting IL-4 production from basophils. Journal of Immunology (Baltimore, Md. : 1950). 183: 3652-60. PMID 19710468 DOI: 10.4049/jimmunol.0900864  0.72
2009 Shilling RA, Clay BS, Tesciuba AG, Berry EL, Lu T, Moore TV, Bandukwala HS, Tong J, Weinstock JV, Flavell RA, Horan T, Yoshinaga SK, Welcher AA, Cannon JL, Sperling AI. CD28 and ICOS play complementary non-overlapping roles in the development of Th2 immunity in vivo. Cellular Immunology. 259: 177-84. PMID 19646680 DOI: 10.1016/j.cellimm.2009.06.013  1
2009 Legrand N, Ploss A, Balling R, Becker PD, Borsotti C, Brezillon N, Debarry J, de Jong Y, Deng H, Di Santo JP, Eisenbarth S, Eynon E, Flavell RA, Guzman CA, Huntington ND, et al. Humanized mice for modeling human infectious disease: challenges, progress, and outlook. Cell Host & Microbe. 6: 5-9. PMID 19616761 DOI: 10.1016/j.chom.2009.06.006  1
2009 Standen CL, Kennedy NJ, Flavell RA, Davis RJ. Signal transduction cross talk mediated by Jun N-terminal kinase-interacting protein and insulin receptor substrate scaffold protein complexes Molecular and Cellular Biology. 29: 4831-4840. PMID 19564410 DOI: 10.1128/MCB.00155-09  1
2009 Kamanaka M, Rainbow D, Schuster-Gossler K, Eynon EE, Chervonsky AV, Wicker LS, Flavell RA. Amino acid polymorphisms altering the glycosylation of IL-2 do not protect from type 1 diabetes in the NOD mouse. Proceedings of the National Academy of Sciences of the United States of America. 106: 11236-40. PMID 19549859 DOI: 10.1073/pnas.0904780106  1
2009 Ince MN, Elliott DE, Setiawan T, Metwali A, Blum A, Chen HL, Urban JF, Flavell RA, Weinstock JV. Role of T cell TGF-beta signaling in intestinal cytokine responses and helminthic immune modulation. European Journal of Immunology. 39: 1870-8. PMID 19544487 DOI: 10.1002/eji.200838956  1
2009 Matza D, Badou A, Jha MK, Willinger T, Antov A, Sanjabi S, Kobayashi KS, Marchesi VT, Flavell RA. Requirement for AHNAK1-mediated calcium signaling during T lymphocyte cytolysis. Proceedings of the National Academy of Sciences of the United States of America. 106: 9785-90. PMID 19497879 DOI: 10.1073/pnas.0902844106  0.72
2009 Stowell NC, Seideman J, Raymond HA, Smalley KA, Lamb RJ, Egenolf DD, Bugelski PJ, Murray LA, Marsters PA, Bunting RA, Flavell RA, Alexopoulou L, San Mateo LR, Griswold DE, Sarisky RT, et al. Long-term activation of TLR3 by poly(I:C) induces inflammation and impairs lung function in mice. Respiratory Research. 10: 43. PMID 19486528 DOI: 10.1186/1465-9921-10-43  1
2009 Liu G, Burns S, Huang G, Boyd K, Proia RL, Flavell RA, Chi H. The receptor S1P1 overrides regulatory T cell-mediated immune suppression through Akt-mTOR. Nature Immunology. 10: 769-77. PMID 19483717 DOI: 10.1038/ni.1743  0.64
2009 Wan YY, Flavell RA. How diverse--CD4 effector T cells and their functions. Journal of Molecular Cell Biology. 1: 20-36. PMID 19482777 DOI: 10.1093/jmcb/mjp001  0.36
2009 O'Connor W, Kamanaka M, Booth CJ, Town T, Nakae S, Iwakura Y, Kolls JK, Flavell RA. A protective function for interleukin 17A in T cell-mediated intestinal inflammation. Nature Immunology. 10: 603-9. PMID 19448631 DOI: 10.1038/ni.1736  1
2009 Demento SL, Eisenbarth SC, Foellmer HG, Platt C, Caplan MJ, Mark Saltzman W, Mellman I, Ledizet M, Fikrig E, Flavell RA, Fahmy TM. Inflammasome-activating nanoparticles as modular systems for optimizing vaccine efficacy. Vaccine. 27: 3013-21. PMID 19428913 DOI: 10.1016/j.vaccine.2009.03.034  1
2009 Lee CG, Hartl D, Lee GR, Koller B, Matsuura H, Da Silva CA, Sohn MH, Cohn L, Homer RJ, Kozhich AA, Humbles A, Kearley J, Coyle A, Chupp G, Reed J, ... Flavell RA, et al. Role of breast regression protein 39 (BRP-39)/chitinase 3-like-1 in Th2 and IL-13-induced tissue responses and apoptosis. The Journal of Experimental Medicine. 206: 1149-66. PMID 19414556 DOI: 10.1084/jem.20081271  1
2009 Galluzzi L, Aaronson SA, Abrams J, Alnemri ES, Andrews DW, Baehrecke EH, Bazan NG, Blagosklonny MV, Blomgren K, Borner C, Bredesen DE, Brenner C, Castedo M, Cidlowski JA, Ciechanover A, ... ... Flavell RA, et al. Guidelines for the use and interpretation of assays for monitoring cell death in higher eukaryotes. Cell Death and Differentiation. 16: 1093-107. PMID 19373242 DOI: 10.1038/cdd.2009.44  1
2009 Zenewicz LA, Antov A, Flavell RA. CD4 T-cell differentiation and inflammatory bowel disease. Trends in Molecular Medicine. 15: 199-207. PMID 19362058 DOI: 10.1016/j.molmed.2009.03.002  0.72
2009 Steenblock ER, Wrzesinski SH, Flavell RA, Fahmy TM. Antigen presentation on artificial acellular substrates: modular systems for flexible, adaptable immunotherapy. Expert Opinion On Biological Therapy. 9: 451-64. PMID 19344282 DOI: 10.1517/14712590902849216  1
2009 Hartl D, He CH, Koller B, Da Silva CA, Kobayashi Y, Lee CG, Flavell RA, Elias JA. Acidic mammalian chitinase regulates epithelial cell apoptosis via a chitinolytic-independent mechanism. Journal of Immunology (Baltimore, Md. : 1950). 182: 5098-106. PMID 19342690 DOI: 10.4049/jimmunol.0803446  1
2009 Huber S, Stahl FR, Schrader J, Lüth S, Presser K, Carambia A, Flavell RA, Werner S, Blessing M, Herkel J, Schramm C. Activin a promotes the TGF-beta-induced conversion of CD4+CD25- T cells into Foxp3+ induced regulatory T cells. Journal of Immunology (Baltimore, Md. : 1950). 182: 4633-40. PMID 19342638 DOI: 10.4049/jimmunol.0803143  1
2009 Cone RE, Chattopadhyay S, Sharafieh R, Lemire Y, O'Rourke J, Flavell RA, Clark RB. T cell sensitivity to TGF-beta is required for the effector function but not the generation of splenic CD8+ regulatory T cells induced via the injection of antigen into the anterior chamber. International Immunology. 21: 567-74. PMID 19325036 DOI: 10.1093/intimm/dxp023  1
2009 Odegard JM, DiPlacido LD, Greenwald L, Kashgarian M, Kono DH, Dong C, Flavell RA, Craft J. ICOS controls effector function but not trafficking receptor expression of kidney-infiltrating effector T cells in murine lupus. Journal of Immunology (Baltimore, Md. : 1950). 182: 4076-84. PMID 19299705 DOI: 10.4049/jimmunol.0800758  1
2009 Mikkelsen SS, Jensen SB, Chiliveru S, Melchjorsen J, Julkunen I, Gaestel M, Arthur JS, Flavell RA, Ghosh S, Paludan SR. RIG-I-mediated activation of p38 MAPK is essential for viral induction of interferon and activation of dendritic cells: dependence on TRAF2 and TAK1. The Journal of Biological Chemistry. 284: 10774-82. PMID 19224920 DOI: 10.1074/jbc.M807272200  1
2009 Town T, Bai F, Wang T, Kaplan AT, Qian F, Montgomery RR, Anderson JF, Flavell RA, Fikrig E. Toll-like receptor 7 mitigates lethal West Nile encephalitis via interleukin 23-dependent immune cell infiltration and homing. Immunity. 30: 242-53. PMID 19200759 DOI: 10.1016/j.immuni.2008.11.012  1
2009 Das M, Sabio G, Jiang F, Rincón M, Flavell RA, Davis RJ. Induction of hepatitis by JNK-mediated expression of TNF-alpha. Cell. 136: 249-60. PMID 19167327 DOI: 10.1016/j.cell.2008.11.017  0.48
2009 Amsen D, Antov A, Flavell RA. The different faces of Notch in T-helper-cell differentiation. Nature Reviews. Immunology. 9: 116-24. PMID 19165228 DOI: 10.1038/nri2488  0.72
2009 Rosenzweig HL, Jann MM, Glant TT, Martin TM, Planck SR, van Eden W, van Kooten PJ, Flavell RA, Kobayashi KS, Rosenbaum JT, Davey MP. Activation of nucleotide oligomerization domain 2 exacerbates a murine model of proteoglycan-induced arthritis. Journal of Leukocyte Biology. 85: 711-8. PMID 19129483 DOI: 10.1189/jlb.0808478  1
2009 Ma DK, Jang MH, Guo JU, Kitabatake Y, Chang ML, Pow-Anpongkul N, Flavell RA, Lu B, Ming GL, Song H. Neuronal activity-induced Gadd45b promotes epigenetic DNA demethylation and adult neurogenesis. Science (New York, N.Y.). 323: 1074-7. PMID 19119186 DOI: 10.1126/science.1166859  1
2009 Moritoki Y, Zhang W, Tsuneyama K, Yoshida K, Wakabayashi K, Yang GX, Bowlus C, Ridgway WM, Ueno Y, Ansari AA, Coppel RL, Mackay IR, Flavell RA, Gershwin ME, Lian ZX. B cells suppress the inflammatory response in a mouse model of primary biliary cirrhosis. Gastroenterology. 136: 1037-47. PMID 19118554 DOI: 10.1053/j.gastro.2008.11.035  1
2009 Brochard V, Combadière B, Prigent A, Laouar Y, Perrin A, Beray-Berthat V, Bonduelle O, Alvarez-Fischer D, Callebert J, Launay JM, Duyckaerts C, Flavell RA, Hirsch EC, Hunot S. Infiltration of CD4+ lymphocytes into the brain contributes to neurodegeneration in a mouse model of Parkinson disease. The Journal of Clinical Investigation. 119: 182-92. PMID 19104149 DOI: 10.1172/JCI36470  0.32
2009 Lim AK, Nikolic-Paterson DJ, Ma FY, Ozols E, Thomas MC, Flavell RA, Davis RJ, Tesch GH. Role of MKK3-p38 MAPK signalling in the development of type 2 diabetes and renal injury in obese db/db mice. Diabetologia. 52: 347-58. PMID 19066844 DOI: 10.1007/s00125-008-1215-5  0.48
2009 Krendel M, Kim SV, Willinger T, Wang T, Kashgarian M, Flavell RA, Mooseker MS. Disruption of Myosin 1e promotes podocyte injury. Journal of the American Society of Nephrology : Jasn. 20: 86-94. PMID 19005011 DOI: 10.1681/ASN.2007111172  1
2009 Archer KA, Alexopoulou L, Flavell RA, Roy CR. Multiple MyD88-dependent responses contribute to pulmonary clearance of Legionella pneumophila. Cellular Microbiology. 11: 21-36. PMID 18782351 DOI: 10.1111/j.1462-5822.2008.01234.x  1
2008 Zenewicz LA, Yancopoulos GD, Valenzuela DM, Murphy AJ, Stevens S, Flavell RA. Innate and adaptive interleukin-22 protects mice from inflammatory bowel disease. Immunity. 29: 947-57. PMID 19100701 DOI: 10.1016/j.immuni.2008.11.003  1
2008 Shin S, Case CL, Archer KA, Nogueira CV, Kobayashi KS, Flavell RA, Roy CR, Zamboni DS. Type IV secretion-dependent activation of host MAP kinases induces an increased proinflammatory cytokine response to Legionella pneumophila. Plos Pathogens. 4: e1000220. PMID 19043549 DOI: 10.1371/journal.ppat.1000220  1
2008 Ries V, Silva RM, Oo TF, Cheng HC, Rzhetskaya M, Kholodilov N, Flavell RA, Kuan CY, Rakic P, Burke RE. JNK2 and JNK3 combined are essential for apoptosis in dopamine neurons of the substantia nigra, but are not required for axon degeneration. Journal of Neurochemistry. 107: 1578-88. PMID 19014392 DOI: 10.1111/j.1471-4159.2008.05713.x  1
2008 Odegard JM, Marks BR, DiPlacido LD, Poholek AC, Kono DH, Dong C, Flavell RA, Craft J. ICOS-dependent extrafollicular helper T cells elicit IgG production via IL-21 in systemic autoimmunity. The Journal of Experimental Medicine. 205: 2873-86. PMID 18981236 DOI: 10.1084/jem.20080840  1
2008 Divangahi M, Mostowy S, Coulombe F, Kozak R, Guillot L, Veyrier F, Kobayashi KS, Flavell RA, Gros P, Behr MA. NOD2-deficient mice have impaired resistance to Mycobacterium tuberculosis infection through defective innate and adaptive immunity. Journal of Immunology (Baltimore, Md. : 1950). 181: 7157-65. PMID 18981137 DOI: 10.4049/jimmunol.181.10.7157  1
2008 Stephens TA, Nikoopour E, Rider BJ, Leon-Ponte M, Chau TA, Mikolajczak S, Chaturvedi P, Lee-Chan E, Flavell RA, Haeryfar SM, Madrenas J, Singh B. Dendritic cell differentiation induced by a self-peptide derived from apolipoprotein E. Journal of Immunology (Baltimore, Md. : 1950). 181: 6859-71. PMID 18981105 DOI: 10.4049/jimmunol.181.10.6859  1
2008 Chi H, Flavell RA. Acetylation of MKP-1 and the control of inflammation. Science Signaling. 1: pe44. PMID 18922786 DOI: 10.1126/scisignal.141pe44  0.64
2008 Murray LA, Knight DA, McAlonan L, Argentieri R, Joshi A, Shaheen F, Cunningham M, Alexopolou L, Flavell RA, Sarisky RT, Hogaboam CM. Deleterious role of TLR3 during hyperoxia-induced acute lung injury. American Journal of Respiratory and Critical Care Medicine. 178: 1227-37. PMID 18849495 DOI: 10.1164/rccm.200807-1020OC  1
2008 Wan YY, Flavell RA. TGF-beta and regulatory T cell in immunity and autoimmunity. Journal of Clinical Immunology. 28: 647-59. PMID 18792765 DOI: 10.1007/s10875-008-9251-y  0.36
2008 Brown MR, Kronengold J, Gazula VR, Spilianakis CG, Flavell RA, von Hehn CA, Bhattacharjee A, Kaczmarek LK. Amino-termini isoforms of the Slack K+ channel, regulated by alternative promoters, differentially modulate rhythmic firing and adaptation. The Journal of Physiology. 586: 5161-79. PMID 18787033 DOI: 10.1113/jphysiol.2008.160861  1
2008 Breunig JJ, Sarkisian MR, Arellano JI, Morozov YM, Ayoub AE, Sojitra S, Wang B, Flavell RA, Rakic P, Town T. Primary cilia regulate hippocampal neurogenesis by mediating sonic hedgehog signaling. Proceedings of the National Academy of Sciences of the United States of America. 105: 13127-32. PMID 18728187 DOI: 10.1073/pnas.0804558105  1
2008 Filippi CM, Juedes AE, Oldham JE, Ling E, Togher L, Peng Y, Flavell RA, von Herrath MG. Transforming growth factor-beta suppresses the activation of CD8+ T-cells when naive but promotes their survival and function once antigen experienced: a two-faced impact on autoimmunity. Diabetes. 57: 2684-92. PMID 18689691 DOI: 10.2337/db08-0609  1
2008 Laouar Y, Town T, Jeng D, Tran E, Wan Y, Kuchroo VK, Flavell RA. TGF-beta signaling in dendritic cells is a prerequisite for the control of autoimmune encephalomyelitis. Proceedings of the National Academy of Sciences of the United States of America. 105: 10865-70. PMID 18669656 DOI: 10.1073/pnas.0805058105  1
2008 Wang S, Welte T, McGargill M, Town T, Thompson J, Anderson JF, Flavell RA, Fikrig E, Hedrick SM, Wang T. Drak2 contributes to West Nile virus entry into the brain and lethal encephalitis. Journal of Immunology (Baltimore, Md. : 1950). 181: 2084-91. PMID 18641347  1
2008 Cassel SL, Eisenbarth SC, Iyer SS, Sadler JJ, Colegio OR, Tephly LA, Carter AB, Rothman PB, Flavell RA, Sutterwala FS. The Nalp3 inflammasome is essential for the development of silicosis. Proceedings of the National Academy of Sciences of the United States of America. 105: 9035-40. PMID 18577586 DOI: 10.1073/pnas.0803933105  1
2008 Fujita J, Crane AM, Souza MK, Dejosez M, Kyba M, Flavell RA, Thomson JA, Zwaka TP. Caspase activity mediates the differentiation of embryonic stem cells. Cell Stem Cell. 2: 595-601. PMID 18522852 DOI: 10.1016/j.stem.2008.04.001  1
2008 Town T, Laouar Y, Pittenger C, Mori T, Szekely CA, Tan J, Duman RS, Flavell RA. Blocking TGF-beta-Smad2/3 innate immune signaling mitigates Alzheimer-like pathology. Nature Medicine. 14: 681-7. PMID 18516051 DOI: 10.1038/nm1781  1
2008 Rosenzweig HL, Martin TM, Planck SR, Galster K, Jann MM, Davey MP, Kobayashi K, Flavell RA, Rosenbaum JT. Activation of NOD2 in vivo induces IL-1beta production in the eye via caspase-1 but results in ocular inflammation independently of IL-1 signaling. Journal of Leukocyte Biology. 84: 529-36. PMID 18495787 DOI: 10.1189/jlb.0108015  1
2008 Lafon M, Mégret F, Meuth SG, Simon O, Velandia Romero ML, Lafage M, Chen L, Alexopoulou L, Flavell RA, Prehaud C, Wiendl H. Detrimental contribution of the immuno-inhibitor B7-H1 to rabies virus encephalitis. Journal of Immunology (Baltimore, Md. : 1950). 180: 7506-15. PMID 18490751 DOI: 10.4049/jimmunol.180.11.7506  1
2008 Singh A, Carson WF, Secor ER, Guernsey LA, Flavell RA, Clark RB, Thrall RS, Schramm CM. Regulatory role of B cells in a murine model of allergic airway disease. Journal of Immunology (Baltimore, Md. : 1950). 180: 7318-26. PMID 18490731 DOI: 10.4049/jimmunol.180.11.7318  1
2008 Yang GX, Lian ZX, Chuang YH, Moritoki Y, Lan RY, Wakabayashi K, Ansari AA, Flavell RA, Ridgway WM, Coppel RL, Tsuneyama K, Mackay IR, Gershwin ME. Adoptive transfer of CD8(+) T cells from transforming growth factor beta receptor type II (dominant negative form) induces autoimmune cholangitis in mice. Hepatology (Baltimore, Md.). 47: 1974-82. PMID 18452147 DOI: 10.1002/hep.22226  1
2008 Pappu BP, Borodovsky A, Zheng TS, Yang X, Wu P, Dong X, Weng S, Browning B, Scott ML, Li M, Su L, Tian Q, Schneider P, Flavell RA, Dong C, et al. TL1A-DR3 interaction regulates Th17 cell function and Th17-mediated autoimmune disease Journal of Experimental Medicine. 205: 1049-1062. PMID 18411337 DOI: 10.1084/jem.20071364  1
2008 Couper KN, Blount DG, Wilson MS, Hafalla JC, Belkaid Y, Kamanaka M, Flavell RA, de Souza JB, Riley EM. IL-10 from CD4CD25Foxp3CD127 adaptive regulatory T cells modulates parasite clearance and pathology during malaria infection. Plos Pathogens. 4: e1000004. PMID 18401464 DOI: 10.1371/journal.ppat.1000004  1
2008 Rosenzweig HL, Martin TM, Jann MM, Planck SR, Davey MP, Kobayashi K, Flavell RA, Rosenbaum JT. NOD2, the gene responsible for familial granulomatous uveitis, in a mouse model of uveitis. Investigative Ophthalmology & Visual Science. 49: 1518-24. PMID 18385071 DOI: 10.1167/iovs.07-1174  1
2008 Mohanty S, Town T, Yagi T, Scheidig C, Kwan KY, Allore HG, Flavell RA, Shaw AC. Defective p53 engagement after the induction of DNA damage in cells deficient in topoisomerase 3beta. Proceedings of the National Academy of Sciences of the United States of America. 105: 5063-8. PMID 18367668 DOI: 10.1073/pnas.0801235105  1
2008 Williams A, Flavell RA. The role of CTCF in regulating nuclear organization. The Journal of Experimental Medicine. 205: 747-50. PMID 18347103 DOI: 10.1084/jem.20080066  0.44
2008 Kim SV, Flavell RA. Myosin I: from yeast to human. Cellular and Molecular Life Sciences : Cmls. 65: 2128-37. PMID 18344022 DOI: 10.1007/s00018-008-7435-5  0.56
2008 Ting JP, Lovering RC, Alnemri ES, Bertin J, Boss JM, Davis BK, Flavell RA, Girardin SE, Godzik A, Harton JA, Hoffman HM, Hugot JP, Inohara N, Mackenzie A, Maltais LJ, et al. The NLR gene family: a standard nomenclature. Immunity. 28: 285-7. PMID 18341998 DOI: 10.1016/j.immuni.2008.02.005  1
2008 Chi H, Flavell RA. Innate recognition of non-self nucleic acids. Genome Biology. 9: 211. PMID 18341708 DOI: 10.1186/gb-2008-9-3-211  0.64
2008 Fan TM, Kranz DM, Flavell RA, Roy EJ. Costimulatory strength influences the differential effects of transforming growth factor beta1 for the generation of CD8+ regulatory T cells. Molecular Immunology. 45: 2937-50. PMID 18321576 DOI: 10.1016/j.molimm.2008.01.019  1
2008 Kang SS, Bloom SM, Norian LA, Geske MJ, Flavell RA, Stappenbeck TS, Allen PM. An antibiotic-responsive mouse model of fulminant ulcerative colitis. Plos Medicine. 5: e41. PMID 18318596 DOI: 10.1371/journal.pmed.0050041  1
2008 Jacquet S, Nishino Y, Kumphune S, Sicard P, Clark JE, Kobayashi KS, Flavell RA, Eickhoff J, Cotten M, Marber MS. The role of RIP2 in p38 MAPK activation in the stressed heart. The Journal of Biological Chemistry. 283: 11964-71. PMID 18310079 DOI: 10.1074/jbc.M707750200  1
2008 Hawiger D, Tran E, Du W, Booth CJ, Wen L, Dong C, Flavell RA. ICOS mediates the development of insulin-dependent diabetes mellitus in nonobese diabetic mice. Journal of Immunology (Baltimore, Md. : 1950). 180: 3140-7. PMID 18292537 DOI: 10.4049/jimmunol.180.5.3140  1
2008 Town T, Breunig JJ, Sarkisian MR, Spilianakis C, Ayoub AE, Liu X, Ferrandino AF, Gallagher AR, Li MO, Rakic P, Flavell RA. The stumpy gene is required for mammalian ciliogenesis. Proceedings of the National Academy of Sciences of the United States of America. 105: 2853-8. PMID 18287022 DOI: 10.1073/pnas.0712385105  1
2008 Reig N, Jiang A, Couture R, Sutterwala FS, Ogura Y, Flavell RA, Mellman I, van der Goot FG. Maturation modulates caspase-1-independent responses of dendritic cells to Anthrax lethal toxin. Cellular Microbiology. 10: 1190-207. PMID 18194483 DOI: 10.1111/j.1462-5822.2008.01121.x  1
2008 Hall HT, Wilhelm MT, Saibil SD, Mak TW, Flavell RA, Ohashi PS. RIP2 contributes to Nod signaling but is not essential for T cell proliferation, T helper differentiation or TLR responses. European Journal of Immunology. 38: 64-72. PMID 18085666 DOI: 10.1002/eji.200737393  1
2008 Pedra JH, Mattner J, Tao J, Kerfoot SM, Davis RJ, Flavell RA, Askenase PW, Yin Z, Fikrig E. c-Jun NH2-terminal kinase 2 inhibits gamma interferon production during Anaplasma phagocytophilum infection. Infection and Immunity. 76: 308-16. PMID 17998313 DOI: 10.1128/IAI.00599-07  1
2007 Willingham SB, Bergstralh DT, O'Connor W, Morrison AC, Taxman DJ, Duncan JA, Barnoy S, Venkatesan MM, Flavell RA, Deshmukh M, Hoffman HM, Ting JP. Microbial pathogen-induced necrotic cell death mediated by the inflammasome components CIAS1/cryopyrin/NLRP3 and ASC. Cell Host & Microbe. 2: 147-59. PMID 18005730 DOI: 10.1016/j.chom.2007.07.009  1
2007 Deane JA, Pisitkun P, Barrett RS, Feigenbaum L, Town T, Ward JM, Flavell RA, Bolland S. Control of toll-like receptor 7 expression is essential to restrict autoimmunity and dendritic cell proliferation. Immunity. 27: 801-10. PMID 17997333 DOI: 10.1016/j.immuni.2007.09.009  1
2007 Awasthi A, Carrier Y, Peron JPS, Bettelli E, Kamanaka M, Flavell RA, Kuchroo VK, Oukka M, Weiner HL. A dominant function for interleukin 27 in generating interleukin 10-producing anti-inflammatory T cells Nature Immunology. 8: 1380-1389. PMID 17994022 DOI: 10.1038/ni1541  1
2007 Wan YY, Flavell RA. 'Yin-Yang' functions of transforming growth factor-beta and T regulatory cells in immune regulation. Immunological Reviews. 220: 199-213. PMID 17979848 DOI: 10.1111/j.1600-065X.2007.00565.x  0.36
2007 Kim ST, Fields PE, Flavell RA. Demethylation of a specific hypersensitive site in the Th2 locus control region. Proceedings of the National Academy of Sciences of the United States of America. 104: 17052-7. PMID 17940027 DOI: 10.1073/pnas.0708293104  0.68
2007 Kaplan DH, Li MO, Jenison MC, Shlomchik WD, Flavell RA, Shlomchik MJ. Autocrine/paracrine TGFbeta1 is required for the development of epidermal Langerhans cells. The Journal of Experimental Medicine. 204: 2545-52. PMID 17938236 DOI: 10.1084/jem.20071401  0.44
2007 Zenewicz LA, Yancopoulos GD, Valenzuela DM, Murphy AJ, Karow M, Flavell RA. Interleukin-22 but not interleukin-17 provides protection to hepatocytes during acute liver inflammation. Immunity. 27: 647-59. PMID 17919941 DOI: 10.1016/j.immuni.2007.07.023  1
2007 Menon S, Chi H, Zhang H, Deng XW, Flavell RA, Wei N. COP9 signalosome subunit 8 is essential for peripheral T cell homeostasis and antigen receptor-induced entry into the cell cycle from quiescence. Nature Immunology. 8: 1236-45. PMID 17906629 DOI: 10.1038/ni1514  0.64
2007 Das M, Jiang F, Sluss HK, Zhang C, Shokat KM, Flavell RA, Davis RJ. Suppression of p53-dependent senescence by the JNK signal transduction pathway. Proceedings of the National Academy of Sciences of the United States of America. 104: 15759-64. PMID 17893331 DOI: 10.1073/pnas.0707782104  0.48
2007 Wilson MS, Elnekave E, Mentink-Kane MM, Hodges MG, Pesce JT, Ramalingam TR, Thompson RW, Kamanaka M, Flavell RA, Keane-Myers A, Cheever AW, Wynn TA. IL-13Ralpha2 and IL-10 coordinately suppress airway inflammation, airway-hyperreactivity, and fibrosis in mice. The Journal of Clinical Investigation. 117: 2941-51. PMID 17885690 DOI: 10.1172/JCI31546  1
2007 Pedra JH, Sutterwala FS, Sukumaran B, Ogura Y, Qian F, Montgomery RR, Flavell RA, Fikrig E. ASC/PYCARD and caspase-1 regulate the IL-18/IFN-gamma axis during Anaplasma phagocytophilum infection. Journal of Immunology (Baltimore, Md. : 1950). 179: 4783-91. PMID 17878377 DOI: 10.4049/jimmunol.179.7.4783  1
2007 Wrzesinski SH, Wan YY, Flavell RA. Transforming growth factor-beta and the immune response: implications for anticancer therapy. Clinical Cancer Research : An Official Journal of the American Association For Cancer Research. 13: 5262-70. PMID 17875754 DOI: 10.1158/1078-0432.CCR-07-1157  0.36
2007 Kennedy NJ, Martin G, Ehrhardt AG, Cavanagh-Kyros J, Kuan CY, Rakic P, Flavell RA, Treistman SN, Davis RJ. Requirement of JIP scaffold proteins for NMDA-mediated signal transduction. Genes & Development. 21: 2336-46. PMID 17875667 DOI: 10.1101/gad.1563107  1
2007 Lim JH, Stirling B, Derry J, Koga T, Jono H, Woo CH, Xu H, Bourne P, Ha UH, Ishinaga H, Xu H, Andalibi A, Feng XH, Zhu H, Huang Y, ... ... Flavell RA, et al. Tumor suppressor CYLD regulates acute lung injury in lethal Streptococcus pneumoniae infections. Immunity. 27: 349-60. PMID 17723219 DOI: 10.1016/j.immuni.2007.07.011  0.48
2007 Watanabe A, Hashmi A, Gomes DA, Town T, Badou A, Flavell RA, Mehal WZ. Apoptotic hepatocyte DNA inhibits hepatic stellate cell chemotaxis via toll-like receptor 9. Hepatology (Baltimore, Md.). 46: 1509-18. PMID 17705260 DOI: 10.1002/hep.21867  0.64
2007 Moh A, Iwamoto Y, Chai GX, Zhang SS, Kano A, Yang DD, Zhang W, Wang J, Jacoby JJ, Gao B, Flavell RA, Fu XY. Role of STAT3 in liver regeneration: survival, DNA synthesis, inflammatory reaction and liver mass recovery. Laboratory Investigation; a Journal of Technical Methods and Pathology. 87: 1018-28. PMID 17660847 DOI: 10.1038/labinvest.3700630  1
2007 Amsen D, Antov A, Jankovic D, Sher A, Radtke F, Souabni A, Busslinger M, McCright B, Gridley T, Flavell RA. Direct regulation of Gata3 expression determines the T helper differentiation potential of Notch. Immunity. 27: 89-99. PMID 17658279 DOI: 10.1016/j.immuni.2007.05.021  0.72
2007 Chi H, Flavell RA. Immunology: sensing the enemy within. Nature. 448: 423-4. PMID 17653183 DOI: 10.1038/448423a  0.64
2007 Wan YY, Flavell RA. Regulatory T cells, transforming growth factor-beta, and immune suppression. Proceedings of the American Thoracic Society. 4: 271-6. PMID 17607012 DOI: 10.1513/pats.200701-020AW  0.36
2007 Tong C, Yin Z, Song Z, Dockendorff A, Huang C, Mariadason J, Flavell RA, Davis RJ, Augenlicht LH, Yang W. c-Jun NH2-terminal kinase 1 plays a critical role in intestinal homeostasis and tumor suppression. The American Journal of Pathology. 171: 297-303. PMID 17591974 DOI: 10.2353/ajpath.2007.061036  0.48
2007 Pedra JH, Tao J, Sutterwala FS, Sukumaran B, Berliner N, Bockenstedt LK, Flavell RA, Yin Z, Fikrig E. IL-12/23p40-dependent clearance of Anaplasma phagocytophilum in the murine model of human anaplasmosis. Fems Immunology and Medical Microbiology. 50: 401-10. PMID 17521390 DOI: 10.1111/j.1574-695X.2007.00270.x  1
2007 Fazzari P, Penachioni J, Gianola S, Rossi F, Eickholt BJ, Maina F, Alexopoulou L, Sottile A, Comoglio PM, Flavell RA, Tamagnone L. Plexin-B1 plays a redundant role during mouse development and in tumour angiogenesis. Bmc Developmental Biology. 7: 55. PMID 17519029 DOI: 10.1186/1471-213X-7-55  1
2007 Li MO, Wan YY, Flavell RA. T cell-produced transforming growth factor-beta1 controls T cell tolerance and regulates Th1- and Th17-cell differentiation. Immunity. 26: 579-91. PMID 17481928 DOI: 10.1016/j.immuni.2007.03.014  0.44
2007 Gowen BB, Wong MH, Jung KH, Sanders AB, Mitchell WM, Alexopoulou L, Flavell RA, Sidwell RW. TLR3 is essential for the induction of protective immunity against Punta Toro Virus infection by the double-stranded RNA (dsRNA), poly(I:C12U), but not Poly(I:C): differential recognition of synthetic dsRNA molecules. Journal of Immunology (Baltimore, Md. : 1950). 178: 5200-8. PMID 17404303 DOI: 10.4049/jimmunol.178.8.5200  1
2007 Pan Q, Mathison J, Fearns C, Kravchenko VV, Correia JDS, Hoffman HM, Kobayashi KS, Bertin J, Grant EP, Coyle AJ, Sutterwala FS, Ogura Y, Flavell RA, Ulevitch RJ. MDP-induced interleukin-1β processing requires Nod2 and CIAS1/NALP3 Journal of Leukocyte Biology. 82: 177-183. PMID 17403772 DOI: 10.1189/jlb.1006627  1
2007 Clark JE, Flavell RA, Faircloth ME, Davis RJ, Heads RJ, Marber MS. Post-infarction remodeling is independent of mitogen-activated protein kinase kinase 3 (MKK3). Cardiovascular Research. 74: 466-70. PMID 17399693 DOI: 10.1016/j.cardiores.2007.02.027  1
2007 Masud A, Mohapatra A, Lakhani SA, Ferrandino A, Hakem R, Flavell RA. Endoplasmic reticulum stress-induced death of mouse embryonic fibroblasts requires the intrinsic pathway of apoptosis. The Journal of Biological Chemistry. 282: 14132-9. PMID 17371867 DOI: 10.1074/jbc.M700077200  0.48
2007 Chen L, He W, Kim ST, Tao J, Gao Y, Chi H, Intlekofer AM, Harvey B, Reiner SL, Yin Z, Flavell RA, Craft J. Epigenetic and transcriptional programs lead to default IFN-gamma production by gammadelta T cells. Journal of Immunology (Baltimore, Md. : 1950). 178: 2730-6. PMID 17312115 DOI: 10.4049/jimmunol.178.5.2730  1
2007 Tao J, Gao Y, Li MO, He W, Chen L, Harvev B, Davis RJ, Flavell RA, Yin Z. JNK2 negatively regulates CD8+ T cell effector function and anti-tumor immune response. European Journal of Immunology. 37: 818-29. PMID 17301952 DOI: 10.1002/eji.200636726  0.48
2007 Jankovic D, Kullberg MC, Feng CG, Goldszmid RS, Collazo CM, Wilson M, Wynn TA, Kamanaka M, Flavell RA, Sher A. Conventional T-bet(+)Foxp3(-) Th1 cells are the major source of host-protective regulatory IL-10 during intracellular protozoan infection. The Journal of Experimental Medicine. 204: 273-83. PMID 17283209 DOI: 10.1084/jem.20062175  1
2007 Wan YY, Flavell RA. Regulatory T-cell functions are subverted and converted owing to attenuated Foxp3 expression. Nature. 445: 766-70. PMID 17220876 DOI: 10.1038/nature05479  0.36
2007 Bai F, Town T, Pradhan D, Cox J, Ashish, Ledizet M, Anderson JF, Flavell RA, Krueger JK, Koski RA, Fikrig E. Antiviral peptides targeting the west nile virus envelope protein. Journal of Virology. 81: 2047-55. PMID 17151121 DOI: 10.1128/JVI.01840-06  1
2007 Brunelle JK, Shroff EH, Perlman H, Strasser A, Moraes CT, Flavell RA, Danial NN, Keith B, Thompson CB, Chandel NS. Loss of Mcl-1 protein and inhibition of electron transport chain together induce anoxic cell death. Molecular and Cellular Biology. 27: 1222-35. PMID 17145774 DOI: 10.1128/MCB.01535-06  1
2007 Hardarson HS, Baker JS, Yang Z, Purevjav E, Huang CH, Alexopoulou L, Li N, Flavell RA, Bowles NE, Vallejo JG. Toll-like receptor 3 is an essential component of the innate stress response in virus-induced cardiac injury. American Journal of Physiology. Heart and Circulatory Physiology. 292: H251-8. PMID 16936008 DOI: 10.1152/ajpheart.00398.2006  1
2006 Luo P, Reed BD, Tsang TC, Harris DT, Flavell RA. A self-augmenting gene expression cassette for enhanced and sustained transgene expression in the presence of proinflammatory cytokines. Dna and Cell Biology. 25: 659-67. PMID 17184167 DOI: 10.1089/dna.2006.25.659  1
2006 Sarkisian MR, Bartley CM, Chi H, Nakamura F, Hashimoto-Torii K, Torii M, Flavell RA, Rakic P. MEKK4 signaling regulates filamin expression and neuronal migration. Neuron. 52: 789-801. PMID 17145501 DOI: 10.1016/j.neuron.2006.10.024  1
2006 Kamanaka M, Kim ST, Wan YY, Sutterwala FS, Lara-Tejero M, Galán JE, Harhaj E, Flavell RA. Expression of interleukin-10 in intestinal lymphocytes detected by an interleukin-10 reporter knockin tiger mouse. Immunity. 25: 941-52. PMID 17137799 DOI: 10.1016/j.immuni.2006.09.013  0.68
2006 Girgenrath M, Weng S, Kostek CA, Browning B, Wang M, Brown SA, Winkles JA, Michaelson JS, Allaire N, Schneider P, Scott ML, Hsu YM, Yagita H, Flavell RA, Miller JB, et al. TWEAK, via its receptor Fn14, is a novel regulator of mesenchymal progenitor cells and skeletal muscle regeneration. The Embo Journal. 25: 5826-39. PMID 17124496 DOI: 10.1038/sj.emboj.7601441  1
2006 Gowen BB, Hoopes JD, Wong MH, Jung KH, Isakson KC, Alexopoulou L, Flavell RA, Sidwell RW. TLR3 deletion limits mortality and disease severity due to Phlebovirus infection. Journal of Immunology (Baltimore, Md. : 1950). 177: 6301-7. PMID 17056560 DOI: 10.4049/jimmunol.177.9.6301  1
2006 Badou A, Jha MK, Matza D, Mehal WZ, Freichel M, Flockerzi V, Flavell RA. Critical role for the beta regulatory subunits of Cav channels in T lymphocyte function. Proceedings of the National Academy of Sciences of the United States of America. 103: 15529-34. PMID 17028169 DOI: 10.1073/pnas.0607262103  0.44
2006 Kim SV, Mehal WZ, Dong X, Heinrich V, Pypaert M, Mellman I, Dembo M, Mooseker MS, Wu D, Flavell RA. Modulation of cell adhesion and motility in the immune system by Myo1f. Science (New York, N.Y.). 314: 136-9. PMID 17023661 DOI: 10.1126/science.1131920  1
2006 Wang R, Town T, Gokarn V, Flavell RA, Chandawarkar RY. HSP70 enhances macrophage phagocytosis by interaction with lipid raft-associated TLR-7 and upregulating p38 MAPK and PI3K pathways. The Journal of Surgical Research. 136: 58-69. PMID 16979664 DOI: 10.1016/j.jss.2006.06.003  0.64
2006 Jaeschke A, Karasarides M, Ventura JJ, Ehrhardt A, Zhang C, Flavell RA, Shokat KM, Davis RJ. JNK2 is a positive regulator of the cJun transcription factor. Molecular Cell. 23: 899-911. PMID 16973441 DOI: 10.1016/j.molcel.2006.07.028  0.48
2006 Sutterwala FS, Ogura Y, Zamboni DS, Roy CR, Flavell RA. NALP3: a key player in caspase-1 activation. Journal of Endotoxin Research. 12: 251-6. PMID 16953978 DOI: 10.1177/09680519060120040701  1
2006 Tran EH, Azuma YT, Chen M, Weston C, Davis RJ, Flavell RA. Inactivation of JNK1 enhances innate IL-10 production and dampens autoimmune inflammation in the brain. Proceedings of the National Academy of Sciences of the United States of America. 103: 13451-6. PMID 16938889 DOI: 10.1073/pnas.0601155103  1
2006 Wan YY, Flavell RA. The roles for cytokines in the generation and maintenance of regulatory T cells. Immunological Reviews. 212: 114-30. PMID 16903910 DOI: 10.1111/j.0105-2896.2006.00407.x  0.36
2006 Wan YY, Chi H, Xie M, Schneider MD, Flavell RA. The kinase TAK1 integrates antigen and cytokine receptor signaling for T cell development, survival and function. Nature Immunology. 7: 851-8. PMID 16799562 DOI: 10.1038/ni1355  1
2006 Lara-Tejero M, Sutterwala FS, Ogura Y, Grant EP, Bertin J, Coyle AJ, Flavell RA, Galán JE. Role of the caspase-1 inflammasome in Salmonella typhimurium pathogenesis. The Journal of Experimental Medicine. 203: 1407-12. PMID 16717117 DOI: 10.1084/jem.20060206  1
2006 Gitlin L, Barchet W, Gilfillan S, Cella M, Beutler B, Flavell RA, Diamond MS, Colonna M. Essential role of mda-5 in type I IFN responses to polyriboinosinic:polyribocytidylic acid and encephalomyocarditis picornavirus. Proceedings of the National Academy of Sciences of the United States of America. 103: 8459-64. PMID 16714379 DOI: 10.1073/pnas.0603082103  1
2006 Du W, Wong FS, Li MO, Peng J, Qi H, Flavell RA, Sherwin R, Wen L. TGF-β signaling is required for the function of insulin-reactive T regulatory cells Journal of Clinical Investigation. 116: 1360-1370. PMID 16670772 DOI: 10.1172/JCI27030  1
2006 Ma B, Blackburn MR, Lee CG, Homer RJ, Liu W, Flavell RA, Boyden L, Lifton RP, Sun CX, Young HW, Elias JA. Adenosine metabolism and murine strain-specific IL-4-induced inflammation, emphysema, and fibrosis. The Journal of Clinical Investigation. 116: 1274-83. PMID 16670768 DOI: 10.1172/JCI26372  1
2006 Abonia JP, Hallgren J, Jones T, Shi T, Xu Y, Koni P, Flavell RA, Boyce JA, Austen KF, Gurish MF. Alpha-4 integrins and VCAM-1, but not MAdCAM-1, are essential for recruitment of mast cell progenitors to the inflamed lung. Blood. 108: 1588-94. PMID 16670268 DOI: 10.1182/blood-2005-12-012781  1
2006 Doran B, Gherbesi N, Hendricks G, Flavell RA, Davis RJ, Gangwani L. Deficiency of the zinc finger protein ZPR1 causes neurodegeneration Proceedings of the National Academy of Sciences of the United States of America. 103: 7471-7475. PMID 16648254 DOI: 10.1073/pnas.0602057103  1
2006 Lee GR, Kim ST, Spilianakis CG, Fields PE, Flavell RA. T helper cell differentiation: regulation by cis elements and epigenetics. Immunity. 24: 369-79. PMID 16618596 DOI: 10.1016/j.immuni.2006.03.007  0.76
2006 Spilianakis CG, Flavell RA. Molecular biology. Managing associations between different chromosomes. Science (New York, N.Y.). 312: 207-8. PMID 16614205 DOI: 10.1126/science.1126689  0.32
2006 Matalova E, Sharpe PT, Lakhani SA, Roth KA, Flavell RA, Setkova J, Misek I, Tucker AS. Molar tooth development in caspase-3 deficient mice. The International Journal of Developmental Biology. 50: 491-7. PMID 16586350 DOI: 10.1387/ijdb.052117em  1
2006 Kriegel MA, Li MO, Sanjabi S, Wan YY, Flavell RA. Transforming growth factor-beta: recent advances on its role in immune tolerance. Current Rheumatology Reports. 8: 138-44. PMID 16569373 DOI: 10.1007/s11926-006-0054-y  0.44
2006 Pan Q, Kravchenko V, Katz A, Huang S, Ii M, Mathison JC, Kobayashi K, Flavell RA, Schreiber RD, Goeddel D, Ulevitch RJ. NF-kappa B-inducing kinase regulates selected gene expression in the Nod2 signaling pathway. Infection and Immunity. 74: 2121-7. PMID 16552041 DOI: 10.1128/IAI.74.4.2121-2127.2006  1
2006 Li MO, Wan YY, Sanjabi S, Robertson AK, Flavell RA. Transforming growth factor-beta regulation of immune responses. Annual Review of Immunology. 24: 99-146. PMID 16551245 DOI: 10.1146/annurev.immunol.24.021605.090737  0.44
2006 Sutterwala FS, Ogura Y, Szczepanik M, Lara-Tejero M, Lichtenberger GS, Grant EP, Bertin J, Coyle AJ, Galán JE, Askenase PW, Flavell RA. Critical role for NALP3/CIAS1/Cryopyrin in innate and adaptive immunity through its regulation of caspase-1. Immunity. 24: 317-27. PMID 16546100 DOI: 10.1016/j.immuni.2006.02.004  1
2006 Town T, Jeng D, Alexopoulou L, Tan J, Flavell RA. Microglia recognize double-stranded RNA via TLR3. Journal of Immunology (Baltimore, Md. : 1950). 176: 3804-12. PMID 16517751  0.64
2006 Ventura JJ, Hübner A, Zhang C, Flavell RA, Shokat KM, Davis RJ. Chemical genetic analysis of the time course of signal transduction by JNK. Molecular Cell. 21: 701-10. PMID 16507367 DOI: 10.1016/j.molcel.2006.01.018  0.48
2006 Lakhani SA, Masud A, Kuida K, Porter GA, Booth CJ, Mehal WZ, Inayat I, Flavell RA. Caspases 3 and 7: key mediators of mitochondrial events of apoptosis. Science (New York, N.Y.). 311: 847-51. PMID 16469926 DOI: 10.1126/science.1115035  0.48
2006 Chi H, Barry SP, Roth RJ, Wu JJ, Jones EA, Bennett AM, Flavell RA. Dynamic regulation of pro- and anti-inflammatory cytokines by MAPK phosphatase 1 (MKP-1) in innate immune responses. Proceedings of the National Academy of Sciences of the United States of America. 103: 2274-9. PMID 16461893 DOI: 10.1073/pnas.0510965103  1
2006 Querec T, Bennouna S, Alkan S, Laouar Y, Gorden K, Flavell R, Akira S, Ahmed R, Pulendran B. Yellow fever vaccine YF-17D activates multiple dendritic cell subsets via TLR2, 7, 8, and 9 to stimulate polyvalent immunity. The Journal of Experimental Medicine. 203: 413-24. PMID 16461338 DOI: 10.1084/jem.20051720  1
2006 Wu W, Misra RS, Russell JQ, Flavell RA, Rincón M, Budd RC. Proteolytic regulation of nuclear factor of activated T (NFAT) c2 cells and NFAT activity by caspase-3 Journal of Biological Chemistry. 281: 10682-10690. PMID 16455648 DOI: 10.1074/jbc.M511759200  1
2006 Zamboni DS, Kobayashi KS, Kohlsdorf T, Ogura Y, Long EM, Vance RE, Kuida K, Mariathasan S, Dixit VM, Flavell RA, Dietrich WF, Roy CR. The Birc1e cytosolic pattern-recognition receptor contributes to the detection and control of Legionella pneumophila infection. Nature Immunology. 7: 318-25. PMID 16444259 DOI: 10.1038/ni1305  1
2006 Rudd BD, Smit JJ, Flavell RA, Alexopoulou L, Schaller MA, Gruber A, Berlin AA, Lukacs NW. Deletion of TLR3 alters the pulmonary immune environment and mucus production during respiratory syncytial virus infection. Journal of Immunology (Baltimore, Md. : 1950). 176: 1937-42. PMID 16424225 DOI: 10.4049/jimmunol.176.3.1937  1
2006 Wohlfert EA, Gorelik L, Mittler R, Flavell RA, Clark RB. Cutting edge: Deficiency in the E3 ubiquitin ligase Cbl-b results in a multifunctional defect in T cell TGF-β sensitivity in vitro and in vivo Journal of Immunology. 176: 1316-1320. PMID 16424156 DOI: 10.4049/jimmunol.176.3.1316  1
2006 Millet I, Wong FS, Gurr W, Wen L, Zawalich W, Green EA, Flavell RA, Sherwin RS. Targeted expression of the anti-apoptotic gene CrmA to NOD pancreatic islets protects from autoimmune diabetes. Journal of Autoimmunity. 26: 7-15. PMID 16338119 DOI: 10.1016/j.jaut.2005.10.005  1
2006 Spilianakis CG, Lee GR, Flavell RA. Twisting the Th1/Th2 immune response via the retinoid X receptor: lessons from a genetic approach. European Journal of Immunology. 35: 3400-4. PMID 16331704 DOI: 10.1002/eji.200535588  0.32
2006 Mitchell JE, Cvetanovic M, Tibrewal N, Patel V, Colamonici OR, Li MO, Flavell RA, Levine JS, Birge RB, Ucker DS. The presumptive phosphatidylserine receptor is dispensable for innate anti-inflammatory recognition and clearance of apoptotic cells. The Journal of Biological Chemistry. 281: 5718-25. PMID 16317002 DOI: 10.1074/jbc.M509775200  1
2005 Liu L, Tran E, Zhao Y, Huang Y, Flavell R, Lu B. Gadd45 beta and Gadd45 gamma are critical for regulating autoimmunity. The Journal of Experimental Medicine. 202: 1341-7. PMID 16287712 DOI: 10.1084/jem.20051359  1
2005 Lau CM, Broughton C, Tabor AS, Akira S, Flavell RA, Mamula MJ, Christensen SR, Shlomchik MJ, Viglianti GA, Rifkin IR, Marshak-Rothstein A. RNA-associated autoantigens activate B cells by combined B cell antigen receptor/Toll-like receptor 7 engagement. The Journal of Experimental Medicine. 202: 1171-7. PMID 16260486 DOI: 10.1084/jem.20050630  1
2005 Town T, Tan J, Flavell RA, Mullan M. T-cells in Alzheimer's disease. Neuromolecular Medicine. 7: 255-64. PMID 16247185 DOI: 10.1385/NMM:7:3:255  1
2005 Gao Y, Tao J, Li MO, Zhang D, Chi H, Henegariu O, Kaech SM, Davis RJ, Flavell RA, Yin Z. JNK1 is essential for CD8+ T cell-mediated tumor immune surveillance. Journal of Immunology (Baltimore, Md. : 1950). 175: 5783-9. PMID 16237070 DOI: 10.4049/jimmunol.175.9.5783  0.64
2005 Devries-Seimon T, Li Y, Yao PM, Stone E, Wang Y, Davis RJ, Flavell R, Tabas I. Cholesterol-induced macrophage apoptosis requires ER stress pathways and engagement of the type A scavenger receptor. The Journal of Cell Biology. 171: 61-73. PMID 16203857 DOI: 10.1083/jcb.200502078  1
2005 Ijiri K, Zerbini LF, Peng H, Correa RG, Lu B, Walsh N, Zhao Y, Taniguchi N, Huang XL, Otu H, Wang H, Wang JF, Komiya S, Ducy P, Rahman MU, ... Flavell RA, et al. A novel role for GADD45beta as a mediator of MMP-13 gene expression during chondrocyte terminal differentiation. The Journal of Biological Chemistry. 280: 38544-55. PMID 16144844 DOI: 10.1074/jbc.M504202200  1
2005 Kabir AMN, Cao X, Gorog DA, Tanno M, Bassi R, Bellahcene M, Quinlan RA, Davis RJ, Flavell RA, Shattock MJ, Marber MS. Antimycin A induced cardioprotection is dependent on pre-ischemic p38-MAPK activation but independent of MKK3 Journal of Molecular and Cellular Cardiology. 39: 709-717. PMID 16140323 DOI: 10.1016/j.yjmcc.2005.07.012  1
2005 Aoki CA, Borchers AT, Li M, Flavell RA, Bowlus CL, Ansari AA, Gershwin ME. Transforming growth factor beta (TGF-beta) and autoimmunity. Autoimmunity Reviews. 4: 450-9. PMID 16137611 DOI: 10.1016/j.autrev.2005.03.006  1
2005 Kimberly WT, Zheng JB, Town T, Flavell RA, Selkoe DJ. Physiological regulation of the beta-amyloid precursor protein signaling domain by c-Jun N-terminal kinase JNK3 during neuronal differentiation. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 25: 5533-43. PMID 15944381 DOI: 10.1523/JNEUROSCI.4883-04.2005  1
2005 Zheng T, Kang MJ, Crothers K, Zhu Z, Liu W, Lee CG, Rabach LA, Chapman HA, Homer RJ, Aldous D, De Sanctis GT, Desanctis G, Underwood S, Graupe M, Flavell RA, et al. Role of cathepsin S-dependent epithelial cell apoptosis in IFN-gamma-induced alveolar remodeling and pulmonary emphysema. Journal of Immunology (Baltimore, Md. : 1950). 174: 8106-15. PMID 15944319 DOI: 10.4049/jimmunol.174.12.8106  1
2005 Spilianakis CG, Lalioti MD, Town T, Lee GR, Flavell RA. Interchromosomal associations between alternatively expressed loci. Nature. 435: 637-45. PMID 15880101 DOI: 10.1038/nature03574  0.76
2005 Jaeschke A, Rincón M, Doran B, Reilly J, Neuberg D, Greiner DL, Shultz LD, Rossini AA, Flavell RA, Davis RJ. Disruption of the Jnk2 (Mapk9) gene reduces destructive insulitis and diabetes in a mouse model of type I diabetes. Proceedings of the National Academy of Sciences of the United States of America. 102: 6931-5. PMID 15867147 DOI: 10.1073/pnas.0502143102  0.48
2005 Li Y, Schwabe RF, DeVries-Seimon T, Yao PM, Gerbod-Giannone MC, Tall AR, Davis RJ, Flavell R, Brenner DA, Tabas I. Free cholesterol-loaded macrophages are an abundant source of tumor necrosis factor-alpha and interleukin-6: model of NF-kappaB- and map kinase-dependent inflammation in advanced atherosclerosis. The Journal of Biological Chemistry. 280: 21763-72. PMID 15826936 DOI: 10.1074/jbc.M501759200  1
2005 Mehal WZ, Sheikh SZ, Gorelik L, Flavell RA. TGF-beta signaling regulates CD8+ T cell responses to high- and low-affinity TCR interactions. International Immunology. 17: 531-8. PMID 15824070 DOI: 10.1093/intimm/dxh233  1
2005 Wan YY, Flavell RA. Identifying Foxp3-expressing suppressor T cells with a bicistronic reporter. Proceedings of the National Academy of Sciences of the United States of America. 102: 5126-31. PMID 15795373 DOI: 10.1073/pnas.0501701102  0.36
2005 Kim L, Del Rio L, Butcher BA, Mogensen TH, Paludan SR, Flavell RA, Denkers EY. p38 MAPK autophosphorylation drives macrophage IL-12 production during intracellular infection. Journal of Immunology (Baltimore, Md. : 1950). 174: 4178-84. PMID 15778378 DOI: 10.4049/jimmunol.174.7.4178  1
2005 Fahlén L, Read S, Gorelik L, Hurst SD, Coffman RL, Flavell RA, Powrie F. T cells that cannot respond to TGF-beta escape control by CD4(+)CD25(+) regulatory T cells. The Journal of Experimental Medicine. 201: 737-46. PMID 15753207 DOI: 10.1084/jem.20040685  1
2005 Chi H, Sarkisian MR, Rakic P, Flavell RA. Loss of mitogen-activated protein kinase kinase kinase 4 (MEKK4) results in enhanced apoptosis and defective neural tube development. Proceedings of the National Academy of Sciences of the United States of America. 102: 3846-51. PMID 15731347 DOI: 10.1073/pnas.0500026102  1
2005 Chi H, Flavell RA. Cutting edge: regulation of T cell trafficking and primary immune responses by sphingosine 1-phosphate receptor 1. Journal of Immunology (Baltimore, Md. : 1950). 174: 2485-8. PMID 15728452 DOI: 10.4049/jimmunol.174.5.2485  1
2005 Kwon H, Jun HS, Yang Y, Mora C, Mariathasan S, Ohashi PS, Flavell RA, Yoon JW. Development of autoreactive diabetogenic T cells in the thymus of NOD mice. Journal of Autoimmunity. 24: 11-23. PMID 15725572 DOI: 10.1016/j.jaut.2004.10.002  1
2005 Bynoe MS, Viret C, Flavell RA, Janeway CA. T cells from epicutaneously immunized mice are prone to T cell receptor revision. Proceedings of the National Academy of Sciences of the United States of America. 102: 2898-903. PMID 15708975 DOI: 10.1073/pnas.0409880102  1
2005 Abonia JP, Austen KF, Rollins BJ, Joshi SK, Flavell RA, Kuziel WA, Koni PA, Gurish MF. Constitutive homing of mast cell progenitors to the intestine depends on autologous expression of the chemokine receptor CXCR2. Blood. 105: 4308-13. PMID 15705791 DOI: 10.1182/blood-2004-09-3578  1
2005 Townsend KP, Town T, Mori T, Lue LF, Shytle D, Sanberg PR, Morgan D, Fernandez F, Flavell RA, Tan J. CD40 signaling regulates innate and adaptive activation of microglia in response to amyloid beta-peptide. European Journal of Immunology. 35: 901-10. PMID 15688347 DOI: 10.1002/eji.200425585  1
2005 Brecht S, Kirchhof R, Chromik A, Willesen M, Nicolaus T, Raivich G, Wessig J, Waetzig V, Goetz M, Claussen M, Pearse D, Kuan CY, Vaudano E, Behrens A, Wagner E, ... Flavell RA, et al. Specific pathophysiological functions of JNK isoforms in the brain. The European Journal of Neuroscience. 21: 363-77. PMID 15673436 DOI: 10.1111/j.1460-9568.2005.03857.x  1
2005 Badou A, Basavappa S, Desai R, Peng YQ, Matza D, Mehal WZ, Kaczmarek LK, Boulpaep EL, Flavell RA. Requirement of voltage-gated calcium channel beta4 subunit for T lymphocyte functions. Science (New York, N.Y.). 307: 117-21. PMID 15637280 DOI: 10.1126/science.1100582  1
2004 Lee GR, Spilianakis CG, Flavell RA. Hypersensitive site 7 of the TH2 locus control region is essential for expressing TH2 cytokine genes and for long-range intrachromosomal interactions. Nature Immunology. 6: 42-8. PMID 15608641 DOI: 10.1038/ni1148  0.48
2004 Miura M, Chen XD, Allen MR, Bi Y, Gronthos S, Seo BM, Lakhani S, Flavell RA, Feng XH, Robey PG, Young M, Shi S. A crucial role of caspase-3 in osteogenic differentiation of bone marrow stromal stem cells. The Journal of Clinical Investigation. 114: 1704-13. PMID 15599395 DOI: 10.1172/JCI20427  1
2004 Fields PE, Lee GR, Kim ST, Bartsevich VV, Flavell RA. Th2-specific chromatin remodeling and enhancer activity in the Th2 cytokine locus control region. Immunity. 21: 865-76. PMID 15589174 DOI: 10.1016/j.immuni.2004.10.015  0.76
2004 Kuan CY, Schloemer AJ, Lu A, Burns KA, Weng WL, Williams MT, Strauss KI, Vorhees CV, Flavell RA, Davis RJ, Sharp FR, Rakic P. Hypoxia-ischemia induces DNA synthesis without cell proliferation in dying neurons in adult rodent brain. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 24: 10763-72. PMID 15564594 DOI: 10.1523/JNEUROSCI.3883-04.2004  1
2004 Wang T, Town T, Alexopoulou L, Anderson JF, Fikrig E, Flavell RA. Toll-like receptor 3 mediates West Nile virus entry into the brain causing lethal encephalitis. Nature Medicine. 10: 1366-73. PMID 15558055 DOI: 10.1038/nm1140  1
2004 López CB, Moltedo B, Alexopoulou L, Bonifaz L, Flavell RA, Moran TM. TLR-independent induction of dendritic cell maturation and adaptive immunity by negative-strand RNA viruses. Journal of Immunology (Baltimore, Md. : 1950). 173: 6882-9. PMID 15557183 DOI: 10.4049/jimmunol.173.11.6882  1
2004 Ventura JJ, Cogswell P, Flavell RA, Baldwin AS, Davis RJ. JNK potentiates TNF-stimulated necrosis by increasing the production of cytotoxic reactive oxygen species. Genes & Development. 18: 2905-15. PMID 15545623 DOI: 10.1101/gad.1223004  0.48
2004 Gao Y, Qian WP, Dark K, Toraldo G, Lin AS, Guldberg RE, Flavell RA, Weitzmann MN, Pacifici R. Estrogen prevents bone loss through transforming growth factor beta signaling in T cells. Proceedings of the National Academy of Sciences of the United States of America. 101: 16618-23. PMID 15531637 DOI: 10.1073/pnas.0404888101  1
2004 Young HY, Zucker P, Flavell RA, Jevnikar AM, Singh B. Characterization of the role of major histocompatibility complex in type 1 diabetes recurrence after islet transplantation. Transplantation. 78: 509-15. PMID 15446308 DOI: 10.1097/01.TP.0000128907.83111.C6  1
2004 Weston CR, Wong A, Hall JP, Goad MEP, Flavell RA, Davis RJ. The c-Jun NH2-terminal kinase is essential for epidermal growth factor expression during epidermal morphogenesis Proceedings of the National Academy of Sciences of the United States of America. 101: 14114-14119. PMID 15375216 DOI: 10.1073/pnas.0406061101  1
2004 Zhang Y, Blattman JN, Kennedy NJ, Duong J, Nguyen T, Wang Y, Davis RJ, Greenberg PD, Flavell RA, Dong C. Regulation of innate and adaptive immune responses by MAP kinase phosphatase 5. Nature. 430: 793-7. PMID 15306813 DOI: 10.1038/nature02764  1
2004 Lee CG, Cho SJ, Kang MJ, Chapoval SP, Lee PJ, Noble PW, Yehualaeshet T, Lu B, Flavell RA, Milbrandt J, Homer RJ, Elias JA. Early growth response gene 1-mediated apoptosis is essential for transforming growth factor beta1-induced pulmonary fibrosis. The Journal of Experimental Medicine. 200: 377-89. PMID 15289506 DOI: 10.1084/jem.20040104  1
2004 Ventura JJ, Kennedy NJ, Flavell RA, Davis RJ. JNK regulates autocrine expression of TGF-β1 Molecular Cell. 15: 269-278. PMID 15260977 DOI: 10.1016/j.molcel.2004.06.007  1
2004 Lee GR, Flavell RA. Transgenic mice which overproduce Th2 cytokines develop spontaneous atopic dermatitis and asthma. International Immunology. 16: 1155-60. PMID 15226271 DOI: 10.1093/intimm/dxh117  0.68
2004 Amsen D, Blander JM, Lee GR, Tanigaki K, Honjo T, Flavell RA. Instruction of distinct CD4 T helper cell fates by different notch ligands on antigen-presenting cells. Cell. 117: 515-26. PMID 15137944 DOI: 10.1016/S0092-8674(04)00451-9  0.76
2004 Edelmann KH, Richardson-Burns S, Alexopoulou L, Tyler KL, Flavell RA, Oldstone MB. Does Toll-like receptor 3 play a biological role in virus infections? Virology. 322: 231-8. PMID 15110521 DOI: 10.1016/j.virol.2004.01.033  1
2004 Kim SV, Flavell RA. Immunology. CD8alphaalpha and T cell memory. Science (New York, N.Y.). 304: 529-30. PMID 15105485 DOI: 10.1126/science.1097678  0.64
2004 Chi H, Lu B, Takekawa M, Davis RJ, Flavell RA. GADD45beta/GADD45gamma and MEKK4 comprise a genetic pathway mediating STAT4-independent IFNgamma production in T cells. The Embo Journal. 23: 1576-86. PMID 15044949 DOI: 10.1038/sj.emboj.7600173  0.64
2004 Lund JM, Alexopoulou L, Sato A, Karow M, Adams NC, Gale NW, Iwasaki A, Flavell RA. Recognition of single-stranded RNA viruses by Toll-like receptor 7. Proceedings of the National Academy of Sciences of the United States of America. 101: 5598-603. PMID 15034168 DOI: 10.1073/pnas.0400937101  1
2004 Fikrig E, Coyle PK, Schutzer SE, Chen M, Deng Z, Flavell RA. Preferential Presence of Decorin-Binding Protein B (BBA25) and BBA50 Antibodies in Cerebrospinal Fluid of Patients with Neurologic Lyme Disease Journal of Clinical Microbiology. 42: 1243-1246. PMID 15004083 DOI: 10.1128/JCM.42.3.1243-1246.2004  1
2004 Zhang D, Zhang G, Hayden MS, Greenblatt MB, Bussey C, Flavell RA, Ghosh S. A toll-like receptor that prevents infection by uropathogenic bacteria. Science (New York, N.Y.). 303: 1522-6. PMID 15001781 DOI: 10.1126/science.1094351  1
2004 Christen U, Darwiche R, Thomas HE, Wolfe T, Rodrigo E, Chervonsky A, Flavell RA, von Herrath MG. Virally induced inflammation triggers fratricide of Fas-ligand-expressing beta-cells. Diabetes. 53: 591-6. PMID 14988242 DOI: 10.2337/diabetes.53.3.591  1
2004 Xu J, Wang P, Li Y, Li G, Kaczmarek LK, Wu Y, Koni PA, Flavell RA, Desir GV. The voltage-gated potassium channel Kv1.3 regulates peripheral insulin sensitivity. Proceedings of the National Academy of Sciences of the United States of America. 101: 3112-7. PMID 14981264 DOI: 10.1073/pnas.0308450100  1
2004 Fikrig E, Pal U, Chen M, Anderson JF, Flavell RA. OspB antibody prevents Borrelia burgdorferi colonization of Ixodes scapularis. Infection and Immunity. 72: 1755-9. PMID 14977984 DOI: 10.1128/IAI.72.3.1755-1759.2004  1
2004 Fadool DA, Tucker K, Perkins R, Fasciani G, Thompson RN, Parsons AD, Overton JM, Koni PA, Flavell RA, Kaczmarek LK. Kv1.3 channel gene-targeted deletion produces "Super-Smeller Mice" with altered glomeruli, interacting scaffolding proteins, and biophysics. Neuron. 41: 389-404. PMID 14766178 DOI: 10.1016/S0896-6273(03)00844-4  1
2004 Pal U, Yang X, Chen M, Bockenstedt LK, Anderson JF, Flavell RA, Norgard MV, Fikrig E. OspC facilitates Borrelia burgdorferi invasion of Ixodes scapularis salivary glands. The Journal of Clinical Investigation. 113: 220-30. PMID 14722614 DOI: 10.1172/JCI19894  1
2004 Song R, Mahidhara RS, Zhou Z, Hoffman RA, Seol DW, Flavell RA, Billiar TR, Otterbein LE, Choi AM. Carbon monoxide inhibits T lymphocyte proliferation via caspase-dependent pathway. Journal of Immunology (Baltimore, Md. : 1950). 172: 1220-6. PMID 14707100 DOI: 10.4049/jimmunol.172.2.1220  1
2004 Hunot S, Vila M, Teismann P, Davis RJ, Hirsch EC, Przedborski S, Rakic P, Flavell RA. JNK-mediated induction of cyclooxygenase 2 is required for neurodegeneration in a mouse model of Parkinson's disease. Proceedings of the National Academy of Sciences of the United States of America. 101: 665-70. PMID 14704277 DOI: 10.1073/pnas.0307453101  1
2004 Zheng WP, Zhao Q, Zhao X, Li B, Hubank M, Schatz DG, Flavell RA. Up-regulation of Hlx in immature Th cells induces IFN-gamma expression. Journal of Immunology (Baltimore, Md. : 1950). 172: 114-22. PMID 14688316 DOI: 10.4049/jimmunol.172.1.114  1
2003 Chen X, Smith JD, Shi H, Yang DD, Flavell RA, Wolin SL. The Ro autoantigen binds misfolded U2 small nuclear RNAs and assists mammalian cell survival after UV irradiation. Current Biology : Cb. 13: 2206-11. PMID 14680639 DOI: 10.1016/j.cub.2003.11.028  1
2003 Kuan CY, Whitmarsh AJ, Yang DD, Liao G, Schloemer AJ, Dong C, Bao J, Banasiak KJ, Haddad GG, Flavell RA, Davis RJ, Rakic P. A critical role of neural-specific JNK3 for ischemic apoptosis. Proceedings of the National Academy of Sciences of the United States of America. 100: 15184-9. PMID 14657393 DOI: 10.1073/pnas.2336254100  1
2003 Li MO, Sarkisian MR, Mehal WZ, Rakic P, Flavell RA. Phosphatidylserine receptor is required for clearance of apoptotic cells. Science (New York, N.Y.). 302: 1560-3. PMID 14645847 DOI: 10.1126/science.1087621  1
2003 Otterbein LE, Otterbein SL, Ifedigbo E, Liu F, Morse DE, Fearns C, Ulevitch RJ, Knickelbein R, Flavell RA, Choi AM. MKK3 Mitogen-Activated Protein Kinase Pathway Mediates Carbon Monoxide-Induced Protection Against Oxidant-Induced Lung Injury American Journal of Pathology. 163: 2555-2563. PMID 14633627 DOI: 10.1016/S0002-9440(10)63610-3  1
2003 Kano A, Wolfgang MJ, Gao Q, Jacoby J, Chai GX, Hansen W, Iwamoto Y, Pober JS, Flavell RA, Fu XY. Endothelial cells require STAT3 for protection against endotoxin-induced inflammation. The Journal of Experimental Medicine. 198: 1517-25. PMID 14623907 DOI: 10.1084/jem.20030077  1
2003 D'Sa C, Klocke BJ, Cecconi F, Lindsten T, Thompson CB, Korsmeyer SJ, Flavell RA, Roth KA. Caspase regulation of genotoxin-induced neural precursor cell death. Journal of Neuroscience Research. 74: 435-45. PMID 14598320 DOI: 10.1002/jnr.10738  1
2003 Green EA, Gorelik L, McGregor CM, Tran EH, Flavell RA. CD4+CD25+ T regulatory cells control anti-islet CD8+ T cells through TGF-beta-TGF-beta receptor interactions in type 1 diabetes. Proceedings of the National Academy of Sciences of the United States of America. 100: 10878-83. PMID 12949259 DOI: 10.1073/pnas.1834400100  1
2003 Chakrabarti S, Kobayashi KS, Flavell RA, Marks CB, Miyake K, Liston DR, Fowler KT, Gorelick FS, Andrews NW. Impaired membrane resealing and autoimmune myositis in synaptotagmin VII-deficient mice. The Journal of Cell Biology. 162: 543-9. PMID 12925704 DOI: 10.1083/jcb.200305131  1
2003 Kelkar N, Delmotte MH, Weston CR, Barrett T, Sheppard BJ, Flavell RA, Davis RJ. Morphogenesis of the telencephalic commissure requires scaffold protein JNK-interacting protein 3 (JIP3). Proceedings of the National Academy of Sciences of the United States of America. 100: 9843-8. PMID 12897243 DOI: 10.1073/pnas.1733944100  0.48
2003 Brancho D, Tanaka N, Jaeschke A, Ventura JJ, Kelkar N, Tanaka Y, Kyuuma M, Takeshita T, Flavell RA, Davis RJ. Mechanism of p38 MAP kinase activation in vivo. Genes & Development. 17: 1969-78. PMID 12893778 DOI: 10.1101/gad.1107303  0.48
2003 Koni PA, Khanna R, Chang MC, Tang MD, Kaczmarek LK, Schlichter LC, Flavella RA. Compensatory anion currents in Kv1.3 channel-deficient thymocytes. The Journal of Biological Chemistry. 278: 39443-51. PMID 12878608 DOI: 10.1074/jbc.M304879200  1
2003 Lee GR, Fields PE, Griffin TJ, Flavell RA. Regulation of the Th2 cytokine locus by a locus control region. Immunity. 19: 145-53. PMID 12871646 DOI: 10.1016/S1074-7613(03)00179-1  0.76
2003 Morse D, Pischke SE, Zhou Z, Davis RJ, Flavell RA, Loop T, Otterbein SL, Otterbein LE, Choi AM. Suppression of inflammatory cytokine production by carbon monoxide involves the JNK pathway and AP-1. The Journal of Biological Chemistry. 278: 36993-8. PMID 12857751 DOI: 10.1074/jbc.M302942200  0.48
2003 Lamb JA, Ventura JJ, Hess P, Flavell RA, Davis RJ. JunD mediates survival signaling by the JNK signal transduction pathway. Molecular Cell. 11: 1479-89. PMID 12820962 DOI: 10.1016/S1097-2765(03)00203-X  0.48
2003 Xue D, Shi H, Smith JD, Chen X, Noe DA, Cedervall T, Yang DD, Eynon E, Brash DE, Kashgarian M, Flavell RA, Wolin SL. A lupus-like syndrome develops in mice lacking the Ro 60-kDa protein, a major lupus autoantigen. Proceedings of the National Academy of Sciences of the United States of America. 100: 7503-8. PMID 12788971 DOI: 10.1073/pnas.0832411100  1
2003 Weston CR, Wong A, Hall JP, Goad MEP, Flavell RA, Davis RJ. JNK initiates a cytokine cascade that causes Pax2 expression and closure of the optic fissure Genes and Development. 17: 1271-1280. PMID 12756228 DOI: 10.1101/gad.1087303  1
2003 Ventura JJ, Kennedy NJ, Lamb JA, Flavell RA, Davis RJ. c-Jun NH2-terminal kinase is essential for the regulation of AP-1 by tumor necrosis factor Molecular and Cellular Biology. 23: 2871-2882. PMID 12665585 DOI: 10.1128/MCB.23.8.2871-2882.2003  1
2003 Morse D, Otterbein LE, Watkins S, Alber S, Zhou Z, Flavell RA, Davis RJ, Choi AM. Deficiency in the c-Jun NH2-terminal kinase signaling pathway confers susceptibility to hyperoxic lung injury in mice. American Journal of Physiology. Lung Cellular and Molecular Physiology. 285: L250-7. PMID 12651633 DOI: 10.1152/ajplung.00387.2002  0.48
2003 Kennedy NJ, Sluss HK, Jones SN, Bar-Sagi D, Flavell RA, Davis RJ. Suppression of Ras-stimulated transformation by the JNK signal transduction pathway. Genes & Development. 17: 629-37. PMID 12629045 DOI: 10.1101/gad.1062903  1
2003 Blander JM, Sant'Angelo DB, Metz D, Kim SW, Flavell RA, Bottomly K, Janeway CA. A pool of central memory-like CD4 T cells contains effector memory precursors. Journal of Immunology (Baltimore, Md. : 1950). 170: 2940-8. PMID 12626545 DOI: 10.4049/jimmunol.170.6.2940  1
2003 Xu J, Koni PA, Wang P, Li G, Kaczmarek L, Wu Y, Li Y, Flavell RA, Desir GV. The voltage-gated potassium channel Kv1.3 regulates energy homeostasis and body weight. Human Molecular Genetics. 12: 551-9. PMID 12588802 DOI: 10.1093/hmg/ddg049  1
2003 Welte T, Zhang SS, Wang T, Zhang Z, Hesslein DG, Yin Z, Kano A, Iwamoto Y, Li E, Craft JE, Bothwell AL, Fikrig E, Koni PA, Flavell RA, Fu XY. STAT3 deletion during hematopoiesis causes Crohn's disease-like pathogenesis and lethality: a critical role of STAT3 in innate immunity. Proceedings of the National Academy of Sciences of the United States of America. 100: 1879-84. PMID 12571365 DOI: 10.1073/pnas.0237137100  1
2003 Savinov AY, Tcherepanov A, Green EA, Flavell RA, Chervonsky AV. Contribution of Fas to diabetes development. Proceedings of the National Academy of Sciences of the United States of America. 100: 628-32. PMID 12525697 DOI: 10.1073/pnas.0237359100  1
2003 Takai Y, Canning J, Perez GI, Pru JK, Schlezinger JJ, Sherr DH, Kolesnick RN, Yuan J, Flavell RA, Korsmeyer SJ, Tilly JL. Bax, caspase-2, and caspase-3 are required for ovarian follicle loss caused by 4-vinylcyclohexene diepoxide exposure of female mice in vivo Endocrinology. 144: 69-74. PMID 12488331 DOI: 10.1210/en.2002-220814  1
2003 Zhang X, Shan P, Otterbein LE, Alam J, Flavell RA, Davis RJ, Choi AM, Lee PJ. Carbon monoxide inhibition of apoptosis during ischemia-reperfusion lung injury is dependent on the p38 mitogen-activated protein kinase pathway and involves caspase 3. The Journal of Biological Chemistry. 278: 1248-58. PMID 12399465 DOI: 10.1074/jbc.M208419200  0.48
2002 Horng T, Barton GM, Flavell RA, Medzhitov R. The adaptor molecule TIRAP provides signalling specificity for Toll-like receptors. Nature. 420: 329-33. PMID 12447442 DOI: 10.1038/nature01180  1
2002 Le DA, Wu Y, Huang Z, Matsushita K, Plesnila N, Augustinack JC, Hyman BT, Yuan J, Kuida K, Flavell RA, Moskowitz MA. Caspase activation and neuroprotection in caspase-3- deficient mice after in vivo cerebral ischemia and in vitro oxygen glucose deprivation. Proceedings of the National Academy of Sciences of the United States of America. 99: 15188-93. PMID 12415117 DOI: 10.1073/pnas.232473399  1
2002 Tan J, Town T, Crawford F, Mori T, DelleDonne A, Crescentini R, Obregon D, Flavell RA, Mullan MJ. Role of CD40 ligand in amyloidosis in transgenic Alzheimer's mice. Nature Neuroscience. 5: 1288-93. PMID 12402041 DOI: 10.1038/nn968  0.64
2002 Grewal IS, Grewal KD, Wong FS, Wang H, Picarella DE, Janeway CA, Flavell RA. Expression of transgene encoded TGF-beta in islets prevents autoimmune diabetes in NOD mice by a local mechanism. Journal of Autoimmunity. 19: 9-22. PMID 12367555 DOI: 10.1006/jaut.2002.0599  1
2002 Hess P, Pihan G, Sawyers CL, Flavell RA, Davis RJ. Survival signaling mediated by c-Jun NH(2)-terminal kinase in transformed B lymphoblasts. Nature Genetics. 32: 201-5. PMID 12161751 DOI: 10.1038/ng946  0.48
2002 Leonard JR, Klocke BJ, D'Sa C, Flavell RA, Roth KA. Strain-dependent neurodevelopmental abnormalities in caspase-3-deficient mice. Journal of Neuropathology and Experimental Neurology. 61: 673-7. PMID 12152782 DOI: 10.1093/jnen/61.8.673  1
2002 Kobayashi K, Hernandez LD, Galán JE, Janeway CA, Medzhitov R, Flavell RA. IRAK-M is a negative regulator of Toll-like receptor signaling. Cell. 110: 191-202. PMID 12150927 DOI: 10.1016/S0092-8674(02)00827-9  1
2002 Fields PE, Kim ST, Flavell RA. Cutting edge: changes in histone acetylation at the IL-4 and IFN-gamma loci accompany Th1/Th2 differentiation. Journal of Immunology (Baltimore, Md. : 1950). 169: 647-50. PMID 12097365  0.68
2002 Alexopoulou L, Thomas V, Schnare M, Lobet Y, Anguita J, Schoen RT, Medzhitov R, Fikrig E, Flavell RA. Hyporesponsiveness to vaccination with Borrelia burgdorferi OspA in humans and in TLR1- and TLR2-deficient mice. Nature Medicine. 8: 878-84. PMID 12091878 DOI: 10.1038/nm732  1
2002 Anguita J, Barthold SW, Persinski R, Hedrick MN, Huy CA, Davis RJ, Flavell RA, Fikrig E. Murine Lyme arthritis development mediated by p38 mitogen-activated protein kinase activity. Journal of Immunology (Baltimore, Md. : 1950). 168: 6352-7. PMID 12055252 DOI: 10.4049/jimmunol.168.12.6352  1
2002 Lei K, Nimnual A, Zong WX, Kennedy NJ, Flavell RA, Thompson CB, Bar-Sagi D, Davis RJ. The Bax subfamily of Bcl2-related proteins is essential for apoptotic signal transduction by c-Jun NH(2)-terminal kinase. Molecular and Cellular Biology. 22: 4929-42. PMID 12052897 DOI: 10.1128/MCB.22.13.4929-4942.2002  1
2002 Conze D, Krahl T, Kennedy N, Weiss L, Lumsden J, Hess P, Flavell RA, Le Gros G, Davis RJ, Rincón M. c-Jun NH(2)-terminal kinase (JNK)1 and JNK2 have distinct roles in CD8(+) T cell activation. The Journal of Experimental Medicine. 195: 811-23. PMID 11927626 DOI: 10.1084/jem.20011508  0.48
2002 Arbour N, Naniche D, Homann D, Davis RJ, Flavell RA, Oldstone MB. c-Jun NH(2)-terminal kinase (JNK)1 and JNK2 signaling pathways have divergent roles in CD8(+) T cell-mediated antiviral immunity. The Journal of Experimental Medicine. 195: 801-10. PMID 11927625 DOI: 10.1084/jem.20011481  0.48
2002 Kobayashi K, Inohara N, Hernandez LD, Galán JE, Núñez G, Janeway CA, Medzhitov R, Flavell RA. RICK/Rip2/CARDIAK mediates signalling for receptors of the innate and adaptive immune systems. Nature. 416: 194-9. PMID 11894098 DOI: 10.1038/416194a  1
2002 Tan J, Town T, Mori T, Obregon D, Wu Y, DelleDonne A, Rojiani A, Crawford F, Flavell RA, Mullan M. CD40 is expressed and functional on neuronal cells. The Embo Journal. 21: 643-52. PMID 11847112 DOI: 10.1093/emboj/21.4.643  1
2002 Topilski I, Harmelin A, Flavell RA, Levo Y, Shachar I. Preferential Th1 immune response in invariant chain-deficient mice. Journal of Immunology (Baltimore, Md. : 1950). 168: 1610-7. PMID 11823488 DOI: 10.4049/jimmunol.168.4.1610  1
2001 Maric M, Arunachalam B, Phan UT, Dong C, Garrett WS, Cannon KS, Alfonso C, Karlsson L, Flavell RA, Cresswell P. Defective antigen processing in GILT-free mice. Science (New York, N.Y.). 294: 1361-5. PMID 11701933 DOI: 10.1126/science.1065500  1
2001 Alexopoulou L, Holt AC, Medzhitov R, Flavell RA. Recognition of double-stranded RNA and activation of NF-kappaB by Toll-like receptor 3. Nature. 413: 732-8. PMID 11607032 DOI: 10.1038/35099560  1
2001 Zaidi AU, McDonough JS, Klocke BJ, Latham CB, Korsmeyer SJ, Flavell RA, Schmidt RE, Roth KA. Chloroquine-induced neuronal cell death is p53 and Bcl-2 family-dependent but caspase-independent. Journal of Neuropathology and Experimental Neurology. 60: 937-45. PMID 11589424 DOI: 10.1093/jnen/60.10.937  1
2001 Geiger TL, Nguyen P, Leitenberg D, Flavell RA. Integrated src kinase and costimulatory activity enhances signal transduction through single-chain chimeric receptors in T lymphocytes Blood. 98: 2364-2371. PMID 11588032 DOI: 10.1182/blood.V98.8.2364  1
2001 Yu H, Leitenberg D, Li B, Flavell RA. Deficiency of small GTPase Rac2 affects T cell activation Journal of Experimental Medicine. 194: 915-925. PMID 11581314 DOI: 10.1084/jem.194.7.915  1
2001 Whitmarsh AJ, Kuan CY, Kennedy NJ, Kelkar N, Haydar TF, Mordes JP, Appel M, Rossini AA, Jones SN, Flavell RA, Rakic P, Davis RJ. Requirement of the JIP1 scaffold protein for stress-induced JNK activation. Genes & Development. 15: 2421-32. PMID 11562351 DOI: 10.1101/gad.922801  1
2001 Pérez-Melgosa M, Ochs HD, Linsley PS, Laman JD, Van Meurs M, Flavell RA, Ernst RK, Miller SI, Wilson CB. Carrier-mediated enhancement of cognate T cell help: The basis for enhanced immunogenicity of meningococcal outer membrane protein polysaccharide conjugate vaccine European Journal of Immunology. 31: 2373-2381. PMID 11500820 DOI: 10.1002/1521-4141(200108)31:8<2373::AID-IMMU2373>3.0.CO;2-G  1
2001 Wu HJ, Venkataraman C, Estus S, Dong C, Davis RJ, Flavell RA, Bondada S. Positive signaling through CD72 induces mitogen-activated protein kinase activation and synergizes with B cell receptor signals to induce X-linked immunodeficiency B cell proliferation. Journal of Immunology (Baltimore, Md. : 1950). 167: 1263-73. PMID 11466342 DOI: 10.4049/jimmunol.167.3.1263  1
2001 Bruckner SR, Tammariello SP, Kuan CY, Flavell RA, Rakic P, Estus S. JNK3 contributes to c-Jun activation and apoptosis but not oxidative stress in nerve growth factor-deprived sympathetic neurons. Journal of Neurochemistry. 78: 298-303. PMID 11461965 DOI: 10.1046/j.1471-4159.2001.00400.x  1
2001 Rennert PD, Hochman PS, Flavell RA, Chaplin DD, Jayaraman S, Browning JL, Fu YX. Essential role of lymph nodes in contact hypersensitivity revealed in lymphotoxin-alpha-deficient mice. The Journal of Experimental Medicine. 193: 1227-38. PMID 11390430 DOI: 10.1084/jem.193.11.1227  1
2001 Tournier C, Dong C, Turner TK, Jones SN, Flavell RA, Davis RJ. MKK7 is an essential component of the JNK signal transduction pathway activated by proinflammatory cytokines Genes and Development. 15: 1419-1426. PMID 11390361 DOI: 10.1101/gad.888501  1
2001 Dong C, Juedes AE, Temann UA, Shresta S, Allison JP, Ruddle NH, Flavell RA. ICOS co-stimulatory receptor is essential for T-cell activation and function. Nature. 409: 97-101. PMID 11343121 DOI: 10.1038/35051100  1
2001 Lee GR, Fields PE, Flavell RA. Regulation of IL-4 gene expression by distal regulatory elements and GATA-3 at the chromatin level. Immunity. 14: 447-59. PMID 11336690 DOI: 10.1016/S1074-7613(01)00125-X  0.4
2001 Spahn TW, Fontana A, Faria AM, Slavin AJ, Eugster HP, Zhang X, Koni PA, Ruddle NH, Flavell RA, Rennert PD, Weiner HL. Induction of oral tolerance to cellular immune responses in the absence of Peyer's patches. European Journal of Immunology. 31: 1278-87. PMID 11298355 DOI: 10.1002/1521-4141(200104)31:4<1278::AID-IMMU1278>3.0.CO;2-A  1
2001 Grewal IS, Foellmer HG, Grewal KD, Wang H, Lee WP, Tumas D, Janeway CA, Flavell RA. CD62L is required on effector cells for local interactions in the CNS to cause myelin damage in experimental allergic encephalomyelitis Immunity. 14: 291-302. PMID 11290338 DOI: 10.1016/S1074-7613(01)00110-8  1
2000 Iordanov MS, Wong J, Newton DL, Rybak SM, Bright RK, Flavell RA, Davis RJ, Magun BE. Differential requirement for the stress-activated protein kinase/c-Jun NH(2)-terminal kinase in RNAdamage-induced apoptosis in primary and in immortalized fibroblasts. Molecular Cell Biology Research Communications : McBrc. 4: 122-8. PMID 11170843 DOI: 10.1006/mcbr.2000.0266  0.48
2000 Flaishon L, Hershkoviz R, Lantner F, Lider O, Alon R, Levo Y, Flavell RA, Shachar I. Autocrine secretion of interferon gamma negatively regulates homing of immature B cells. The Journal of Experimental Medicine. 192: 1381-8. PMID 11067886 DOI: 10.1084/jem.192.9.1381  1
2000 Zheng TS, Hunot S, Kuida K, Momoi T, Srinivasan A, Nicholson DW, Lazebnik Y, Flavell RA. Deficiency in caspase-9 or caspase-3 induces compensatory caspase activation. Nature Medicine. 6: 1241-7. PMID 11062535 DOI: 10.1038/81343  0.32
2000 Manuelidis L, Zaitsev I, Koni P, Lu ZY, Flavell RA, Fritch W. Follicular dendritic cells and dissemination of Creutzfeldt-Jakob disease. Journal of Virology. 74: 8614-22. PMID 10954563 DOI: 10.1128/JVI.74.18.8614-8622.2000  1
2000 Mencacci A, Bacci A, Cenci E, Montagnoli C, Fiorucci S, Casagrande A, Flavell RA, Bistoni F, Romani L. Interleukin 18 restores defective Th1 immunity to Candida albicans in caspase 1-deficient mice. Infection and Immunity. 68: 5126-31. PMID 10948135 DOI: 10.1128/IAI.68.9.5126-5131.2000  1
2000 Constant SL, Dong C, Yang DD, Wysk M, Davis RJ, Flavell RA. JNK1 is required for T cell-mediated immunity against Leishmania major infection Journal of Immunology. 165: 2671-2676. PMID 10946297 DOI: 10.4049/jimmunol.165.5.2671  1
2000 Zhang F, Rincon M, Flavell RA, Aune TM. Defective Th function induced by a dominant-negative cAMP response element binding protein mutation is reversed by Bcl-2. Journal of Immunology (Baltimore, Md. : 1950). 165: 1762-70. PMID 10925253 DOI: 10.4049/jimmunol.165.4.1762  1
2000 Chow CW, Dong C, Flavell RA, Davis RJ. c-Jun NH(2)-terminal kinase inhibits targeting of the protein phosphatase calcineurin to NFATc1. Molecular and Cellular Biology. 20: 5227-34. PMID 10866678 DOI: 10.1128/MCB.20.14.5227-5234.2000  0.48
2000 Li B, Yu H, Zheng W, Voll R, Na S, Roberts AW, Williams DA, Davis RJ, Ghosh S, Flavell RA. Role of the guanosine triphosphatase Rac2 in T helper 1 cell differentiation. Science (New York, N.Y.). 288: 2219-22. PMID 10864872 DOI: 10.1126/science.288.5474.2219  0.48
2000 Kuan CY, Flavell RA, Rakic P. Programmed cell death in mouse brain development. Results and Problems in Cell Differentiation. 30: 145-62. PMID 10857188 DOI: 10.1007/978-3-540-48002-0_6  1
2000 Kuan CY, Roth KA, Flavell RA, Rakic P. Mechanisms of programmed cell death in the developing brain. Trends in Neurosciences. 23: 291-7. PMID 10856938 DOI: 10.1016/S0166-2236(00)01581-2  1
2000 Millet I, Phillips RJ, Sherwin RS, Ghosh S, Voll RE, Flavell RA, Vignery A, Rincón M. Inhibition of NF-kappaB activity and enhancement of apoptosis by the neuropeptide calcitonin gene-related peptide. The Journal of Biological Chemistry. 275: 15114-21. PMID 10809748 DOI: 10.1074/jbc.275.20.15114  1
2000 Tournier C, Hess P, Yang DD, Xu J, Turner TK, Nimnual A, Bar-Sagi D, Jones SN, Flavell RA, Davis RJ. Requirement of JNK for stress-induced activation of the cytochrome c- mediated death pathway Science. 288: 870-874. PMID 10797012 DOI: 10.1126/science.288.5467.870  1
2000 Selznick LA, Zheng TS, Flavell RA, Rakic P, Roth KA. Amyloid beta-induced neuronal death is bax-dependent but caspase-independent. Journal of Neuropathology and Experimental Neurology. 59: 271-9. PMID 10759182 DOI: 10.1093/jnen/59.4.271  1
2000 Pierre P, Shachar I, Matza D, Gatti E, Flavell RA, Mellman I. Invariant chain controls H2-M proteolysis in mouse splenocytes and dendritic cells. The Journal of Experimental Medicine. 191: 1057-62. PMID 10727467 DOI: 10.1084/jem.191.6.1057  1
2000 Kuhn C, Homer RJ, Zhu Z, Ward N, Flavell RA, Geba GP, Elias JA. Airway hyperresponsiveness and airway obstruction in transgenic mice. Morphologic correlates in mice overexpressing interleukin (IL)-11 and IL-6 in the lung. American Journal of Respiratory Cell and Molecular Biology. 22: 289-95. PMID 10696065 DOI: 10.1165/ajrcmb.22.3.3690  0.36
2000 D'Mello SR, Kuan CY, Flavell RA, Rakic P. Caspase-3 is required for apoptosis-associated DNA fragmentation but not for cell death in neurons deprived of potassium. Journal of Neuroscience Research. 59: 24-31. PMID 10658182 DOI: 10.1002/(SICI)1097-4547(20000101)59:1<24::AID-JNR4>3.0.CO;2-8  1
2000 Diehl NL, Enslen H, Fortner KA, Merritt C, Stetson N, Charland C, Flavell RA, Davis RJ, Rincón M. Activation of the p38 mitogen-activated protein kinase pathway arrests cell cycle progression and differentiation of immature thymocytes in vivo Journal of Experimental Medicine. 191: 321-334. PMID 10637276 DOI: 10.1084/jem.191.2.321  1
2000 Roth KA, Kuan C, Haydar TF, D'Sa-Eipper C, Shindler KS, Zheng TS, Kuida K, Flavell RA, Rakic P. Epistatic and independent functions of caspase-3 and Bcl-X(L) in developmental programmed cell death. Proceedings of the National Academy of Sciences of the United States of America. 97: 466-71. PMID 10618441 DOI: 10.1073/pnas.97.1.466  1
1999 Flavell RA, Li B, Dong C, Lu HT, Yang DD, Enslen H, Tournier C, Whitmarsh A, Wysk M, Conze D, Rincon M, Davis RJ. Molecular basis of T-cell differentiation. Cold Spring Harbor Symposia On Quantitative Biology. 64: 563-71. PMID 11232333 DOI: 10.1101/sqb.1999.64.563  0.48
1999 Flavell RA, Hafler DA. Autoimmunity. What is the turning point? Current Opinion in Immunology. 11: 635-637. PMID 10631547 DOI: 10.1016/S0952-7915(99)00029-1  1
1999 Tan J, Town T, Paris D, Mori T, Suo Z, Crawford F, Mattson MP, Flavell RA, Mullan M. Microglial activation resulting from CD40-CD40L interaction after beta-amyloid stimulation. Science (New York, N.Y.). 286: 2352-5. PMID 10600748 DOI: 10.1126/science.286.5448.2352  1
1999 Cremona O, Di Paolo G, Wenk MR, Lüthi A, Kim WT, Takei K, Daniell L, Nemoto Y, Shears SB, Flavell RA, McCormick DA, De Camilli P. Essential role of phosphoinositide metabolism in synaptic vesicle recycling. Cell. 99: 179-88. PMID 10535736 DOI: 10.1016/S0092-8674(00)81649-9  1
1999 Haydar TF, Kuan CY, Flavell RA, Rakic P. The role of cell death in regulating the size and shape of the mammalian forebrain. Cerebral Cortex (New York, N.Y. : 1991). 9: 621-6. PMID 10498280 DOI: 10.1093/cercor/9.6.621  1
1999 Young MR, Li JJ, Rincón M, Flavell RA, Sathyanarayana BK, Hunziker R, Colburn N. Transgenic mice demonstrate AP-1 (activator protein-1) transactivation is required for tumor promotion Proceedings of the National Academy of Sciences of the United States of America. 96: 9827-9832. PMID 10449779 DOI: 10.1073/pnas.96.17.9827  1
1999 Berger DP, Naniche D, Crowley MT, Koni PA, Flavell RA, Oldstone MB. Lymphotoxin-beta-deficient mice show defective antiviral immunity. Virology. 260: 136-47. PMID 10405365 DOI: 10.1006/viro.1999.9811  0.32
1999 Kuan CY, Yang DD, Samanta Roy DR, Davis RJ, Rakic P, Flavell RA. The Jnk1 and Jnk2 protein kinases are required for regional specific apoptosis during early brain development. Neuron. 22: 667-76. PMID 10230788 DOI: 10.1016/S0896-6273(00)80727-8  0.76
1999 Lu HT, Yang DD, Wysk M, Gatti E, Mellman I, Davis RJ, Flavell RA. Defective IL-12 production in mitogen-activated protein (MAP) kinase kinase 3 (Mkk3)-deficient mice. The Embo Journal. 18: 1845-57. PMID 10202148 DOI: 10.1093/emboj/18.7.1845  1
1999 Wysk M, Yang DD, Lu HT, Flavell RA, Davis RJ. Requirement of mitogen-activated protein kinase kinase 3 (MKK3) for tumor necrosis factor-induced cytokine expression. Proceedings of the National Academy of Sciences of the United States of America. 96: 3763-8. PMID 10097111 DOI: 10.1073/pnas.96.7.3763  0.48
1998 Boyton RJ, Lohmann T, Londei M, Kalbacher H, Halder T, Frater AJ, Douek DC, Leslie RDG, Flavell RA, Altmann DM. Glutamic acid decarboxylase T lymphocyte responses associated with susceptibility or resistance to type I diabetes: Analysis in disease discordant human twins, non-obese diabetic mice and HLA-DQ transgenic mice International Immunology. 10: 1765-1776. PMID 9885897 DOI: 10.1093/intimm/10.12.1765  1
1998 Hilbi H, Moss JE, Hersh D, Chen Y, Arondel J, Banerjee S, Flavell RA, Yuan J, Sansonetti PJ, Zychlinsky A. Shigella-induced apoptosis is dependent on caspase-1 which binds to IpaB. The Journal of Biological Chemistry. 273: 32895-900. PMID 9830039 DOI: 10.1074/jbc.273.49.32895  1
1998 Wen L, Wong FS, Burkly L, Altieri M, Mamalaki C, Kioussis D, Flavell RA, Sherwin RS. Induction of insulitis by glutamic acid decarboxylase peptide-specific and HLA-DQ8-restricted CD4(+) T cells from human DQ transgenic mice. The Journal of Clinical Investigation. 102: 947-57. PMID 9727063 DOI: 10.1172/JCI2723  1
1998 Kuida K, Haydar TF, Kuan CY, Gu Y, Taya C, Karasuyama H, Su MS, Rakic P, Flavell RA. Reduced apoptosis and cytochrome c-mediated caspase activation in mice lacking caspase 9. Cell. 94: 325-37. PMID 9708735 DOI: 10.1016/S0092-8674(00)81476-2  1
1998 Geng L, Solimena M, Flavell RA, Sherwin RS, Hayday AC. Widespread expression of an autoantigen-GAD65 transgene does not tolerize non-obese diabetic mice and can exacerbate disease. Proceedings of the National Academy of Sciences of the United States of America. 95: 10055-60. PMID 9707599 DOI: 10.1073/pnas.95.17.10055  1
1998 Wong FS, Visintin I, Wen L, Granata J, Flavell R, Janeway CA. The role of lymphocyte subsets in accelerated diabetes in nonobese diabetic-rat insulin promoter-B7-1 (NOD-RIP-B7-1) mice Journal of Experimental Medicine. 187: 1985-1993. PMID 9625758 DOI: 10.1084/jem.187.12.1985  1
1998 Swat W, Fujikawa K, Ganiatsas S, Yang D, Xavier RJ, Harris NL, Davidson L, Ferrini R, Davis RJ, Labow MA, Flavell RA, Zon LI, Alt FW. SEK1/MKK4 is required for maintenance of a normal peripheral lymphoid compartment but not for lymphocyte development. Immunity. 8: 625-34. PMID 9620683  0.48
1997 Rincón M, Dérijard B, Chow CW, Davis RJ, Flavell RA. Reprogramming the signalling requirement for AP-1 (activator protein-1) activation during differentiation of precursor CD4+ T-cells into effector Th1 and Th2 cells. Genes and Function. 1: 51-68. PMID 9680328 DOI: 10.1046/j.1365-4624.1997.00007.x  0.48
1997 Yang DD, Kuan CY, Whitmarsh AJ, Rincón M, Zheng TS, Davis RJ, Rakic P, Flavell RA. Absence of excitotoxicity-induced apoptosis in the hippocampus of mice lacking the Jnk3 gene. Nature. 389: 865-70. PMID 9349820 DOI: 10.1038/39899  0.76
1997 Grewal IS, Borrow P, Pamer EG, Oldstone MB, Flavell RA. The CD40-CD154 system in anti-infective host defense. Current Opinion in Immunology. 9: 491-7. PMID 9287184 DOI: 10.1016/S0952-7915(97)80100-8  1
1997 Koni PA, Sacca R, Lawton P, Browning JL, Ruddle NH, Flavell RA. Distinct roles in lymphoid organogenesis for lymphotoxins alpha and beta revealed in lymphotoxin beta-deficient mice. Immunity. 6: 491-500. PMID 9133428 DOI: 10.1016/S1074-7613(00)80292-7  1
1997 Kuan CY, Elliott EA, Flavell RA, Rakic P. Restrictive clonal allocation in the chimeric mouse brain. Proceedings of the National Academy of Sciences of the United States of America. 94: 3374-9. PMID 9096401 DOI: 10.1073/pnas.94.7.3374  0.76
1997 Yang D, Tournier C, Wysk M, Lu HT, Xu J, Davis RJ, Flavell RA. Targeted disruption of the MKK4 gene causes embryonic death, inhibition of c-Jun NH2-terminal kinase activation, and defects in AP-1 transcriptional activity. Proceedings of the National Academy of Sciences of the United States of America. 94: 3004-9. PMID 9096336 DOI: 10.1073/pnas.94.7.3004  0.48
1997 Chervonsky AV, Wang Y, Wong FS, Visintin I, Flavell RA, Janeway CA, Matis LA. The role of Fas in autoimmune diabetes Cell. 89: 17-24. PMID 9094710 DOI: 10.1016/S0092-8674(00)80178-6  1
1997 Gu Y, Kuida K, Tsutsui H, Ku G, Hsiao K, Fleming MA, Hayashi N, Higashino K, Okamura H, Nakanishi K, Kurimoto M, Tanimoto T, Flavell RA, Sato V, Harding MW, et al. Activation of interferon-gamma inducing factor mediated by interleukin-1beta converting enzyme. Science (New York, N.Y.). 275: 206-9. PMID 8999548 DOI: 10.1126/science.275.5297.206  1
1996 Das S, Shraga D, Cannon C, Lam TT, Feng S, Brunet LR, Telford SR, Barthold SW, Flavell RA, Fikrig E. Characterization of a 30-kDa Borrelia burgdorferi substrate-binding protein homologue Research in Microbiology. 147: 739-751. PMID 9296108 DOI: 10.1016/S0923-2508(97)85121-2  1
1996 Tang W, Geba GP, Zheng T, Ray P, Homer RJ, Kuhn C, Flavell RA, Elias JA. Targeted expression of IL-11 in the murine airway causes lymphocytic inflammation, bronchial remodeling, and airways obstruction. The Journal of Clinical Investigation. 98: 2845-53. PMID 8981933 DOI: 10.1172/JCI119113  0.36
1996 Kuida K, Zheng TS, Na S, Kuan C, Yang D, Karasuyama H, Rakic P, Flavell RA. Decreased apoptosis in the brain and premature lethality in CPP32-deficient mice. Nature. 384: 368-72. PMID 8934524 DOI: 10.1038/384368a0  0.76
1996 Grewal IS, Grewal KD, Wong FS, Picarella DE, Janeway CA, Flavell RA. Local expression of transgene encoded TNFα in islets prevents autoimmune diabetes in nonobese diabetic (NOD) mice by preventing the development of auto-reactive islet-specific T cells Journal of Experimental Medicine. 184: 1963-1974. PMID 8920883 DOI: 10.1084/jem.184.5.1963  1
1996 Rathmell JC, Townsend SE, Xu JC, Flavell RA, Goodnow CC. Expansion or elimination of B cells in vivo: dual roles for CD40- and Fas (CD95)-ligands modulated by the B cell antigen receptor. Cell. 87: 319-29. PMID 8861915 DOI: 10.1016/S0092-8674(00)81349-5  1
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