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Richard A Flavell, Ph.D., FRS - Publications

Immunobiology Yale University, New Haven, CT 

500 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2021 Bielecki P, Riesenfeld SJ, Hütter JC, Torlai Triglia E, Kowalczyk MS, Ricardo-Gonzalez RR, Lian M, Amezcua Vesely MC, Kroehling L, Xu H, Slyper M, Muus C, Ludwig LS, Christian E, Tao L, ... ... Flavell RA, et al. Skin-resident innate lymphoid cells converge on a pathogenic effector state. Nature. PMID 33536623 DOI: 10.1038/s41586-021-03188-w  0.583
2020 Perez LG, Kempski J, McGee HM, Pelzcar P, Agalioti T, Giannou A, Konczalla L, Brockmann L, Wahib R, Xu H, Vesely MCA, Soukou S, Steglich B, Bedke T, Manthey C, ... ... Flavell RA, et al. Publisher Correction: TGF-β signaling in Th17 cells promotes IL-22 production and colitis-associated colon cancer. Nature Communications. 11: 5740. PMID 33159069 DOI: 10.1038/s41467-020-19685-x  0.559
2020 Duan Y, Li G, Xu M, Qi X, Deng M, Lin X, Lei Z, Hu Y, Jia Z, Yang Q, Cao G, Liu Z, Wen Q, Li Z, Tang J, ... ... Flavell RA, et al. CFTR is a negative regulator of γδ T cell IFN-γ production and antitumor immunity. Cellular & Molecular Immunology. PMID 32669666 DOI: 10.1038/S41423-020-0499-3  0.376
2020 Xu H, Agalioti T, Zhao J, Steglich B, Wahib R, Vesely MCA, Bielecki P, Bailis W, Jackson R, Perez D, Izbicki J, Licona-Limón P, Kaartinen V, Geginat J, Esplugues E, ... ... Flavell RA, et al. The induction and function of the anti-inflammatory fate of T17 cells. Nature Communications. 11: 3334. PMID 32620760 DOI: 10.1038/S41467-020-17097-5  0.365
2020 Kempski J, Giannou AD, Riecken K, Zhao L, Steglich B, Lücke J, Garcia-Perez L, Karstens KF, Wöstemeier A, Nawrocki M, Pelczar P, Witkowski M, Nilsson S, Konczalla L, Shiri AM, ... ... Flavell RA, et al. IL22BP Mediates the Anti-Tumor Effects of Lymphotoxin Against Colorectal Tumors in Mice and Humans. Gastroenterology. PMID 32585307 DOI: 10.1053/J.Gastro.2020.06.033  0.331
2020 Zhou T, Damsky W, Weizman OE, McGeary MK, Hartmann KP, Rosen CE, Fischer S, Jackson R, Flavell RA, Wang J, Sanmamed MF, Bosenberg MW, Ring AM. IL-18BP is a secreted immune checkpoint and barrier to IL-18 immunotherapy. Nature. PMID 32581358 DOI: 10.1038/S41586-020-2422-6  0.379
2020 Low JS, Farsakoglu Y, Amezcua Vesely MC, Sefik E, Kelly JB, Harman CCD, Jackson R, Shyer JA, Jiang X, Cauley LS, Flavell RA, Kaech SM. Tissue-resident memory T cell reactivation by diverse antigen-presenting cells imparts distinct functional responses. The Journal of Experimental Medicine. 217. PMID 32525985 DOI: 10.1084/Jem.20192291  0.342
2020 Lysenko V, Wildner-Verhey van Wijk N, Zimmermann K, Weller MC, Bühler M, Wildschut MHE, Schürch P, Fritz C, Wagner U, Calabresi L, Psaila B, Flavell RA, Vannucchi AM, Mead AJ, Wild PJ, et al. Enhanced engraftment of human myelofibrosis stem and progenitor cells in MISTRG mice. Blood Advances. 4: 2477-2488. PMID 32502268 DOI: 10.1182/Bloodadvances.2019001364  0.306
2020 Gao Y, Vasic R, Song Y, Teng R, Liu C, Gbyli R, Biancon G, Nelakanti R, Lobben K, Kudo E, Liu W, Ardasheva A, Fu X, Wang X, Joshi P, ... ... Flavell RA, et al. mA Modification Prevents Formation of Endogenous Double-Stranded RNAs and Deleterious Innate Immune Responses during Hematopoietic Development. Immunity. PMID 32497523 DOI: 10.1016/J.Immuni.2020.05.003  0.329
2020 Perez LG, Kempski J, M McGee H, Pelzcar P, Agalioti T, Giannou A, Konczalla L, Brockmann L, Wahib R, Xu H, Vesely MCA, Soukou S, Steglich B, Bedke T, Manthey C, ... ... Flavell RA, et al. TGF-β signaling in Th17 cells promotes IL-22 production and colitis-associated colon cancer. Nature Communications. 11: 2608. PMID 32451418 DOI: 10.1038/S41467-020-16363-W  0.351
2020 Mukherjee S, Kumar R, Tsakem Lenou E, Basrur V, Kontoyiannis DL, Ioakeimidis F, Mosialos G, Theiss AL, Flavell RA, Venuprasad K. Deubiquitination of NLRP6 inflammasome by Cyld critically regulates intestinal inflammation. Nature Immunology. PMID 32424362 DOI: 10.1038/S41590-020-0681-X  0.344
2020 Roulis M, Kaklamanos A, Schernthanner M, Bielecki P, Zhao J, Kaffe E, Frommelt LS, Qu R, Knapp MS, Henriques A, Chalkidi N, Koliaraki V, Jiao J, Brewer JR, Bacher M, ... ... Flavell RA, et al. Paracrine orchestration of intestinal tumorigenesis by a mesenchymal niche. Nature. 580: 524-529. PMID 32322056 DOI: 10.1038/S41586-020-2166-3  0.323
2020 Hwang SS, Lim J, Yu Z, Kong P, Sefik E, Xu H, Harman CCD, Kim LK, Lee GR, Li HB, Flavell RA. mRNA destabilization by BTG1 and BTG2 maintains T cell quiescence. Science (New York, N.Y.). 367: 1255-1260. PMID 32165587 DOI: 10.1126/Science.Aax0194  0.342
2020 Jarret A, Jackson R, Duizer C, Healy ME, Zhao J, Rone JM, Bielecki P, Sefik E, Roulis M, Rice T, Sivanathan KN, Zhou T, Solis AG, Honcharova-Biletska H, Vélez K, ... ... Flavell RA, et al. Enteric Nervous System-Derived IL-18 Orchestrates Mucosal Barrier Immunity. Cell. 180: 813-814. PMID 32084342 DOI: 10.1016/J.Cell.2020.02.004  0.316
2020 Yang Q, Liu X, Liu Q, Guan Z, Luo J, Cao G, Cai R, Li Z, Xu Y, Wu Z, Xu M, Zhang S, Zhang F, Yang H, Lin X, ... ... Flavell R, et al. Roles of mTORC1 and mTORC2 in controlling γδ T1 and γδ T17 differentiation and function. Cell Death and Differentiation. PMID 32001780 DOI: 10.1038/S41418-020-0500-9  0.365
2020 Jarret A, Jackson R, Duizer C, Healy ME, Zhao J, Rone JM, Bielecki P, Sefik E, Roulis M, Rice T, Sivanathan KN, Zhou T, Solis AG, Honcharova-Biletska H, Vélez K, ... ... Flavell RA, et al. Enteric Nervous System-Derived IL-18 Orchestrates Mucosal Barrier Immunity. Cell. 180: 50-63.e12. PMID 31923399 DOI: 10.1016/J.Cell.2019.12.016  0.371
2019 Jang SW, Hwang SS, Kim HS, Kim MK, Lee WH, Hwang SU, Gwak J, Yew SK, Flavell RA, Lee GR. Homeobox protein Hhex negatively regulates Treg cells by inhibiting Foxp3 expression and function. Proceedings of the National Academy of Sciences of the United States of America. PMID 31792183 DOI: 10.1073/Pnas.1907224116  0.395
2019 Hu B, Friedman G, Elinav E, Flavell RA. Transmissible inflammation-induced colorectal cancer in inflammasome-deficient mice. Oncoimmunology. 8: e981995. PMID 31646062 DOI: 10.4161/2162402X.2014.981995  0.327
2019 Amezcua Vesely MC, Pallis P, Bielecki P, Low JS, Zhao J, Harman CCD, Kroehling L, Jackson R, Bailis W, Licona-Limón P, Xu H, Iijima N, Pillai PS, Kaplan DH, Weaver CT, ... ... Flavell RA, et al. Effector T17 Cells Give Rise to Long-Lived T Cells that Are Essential for an Immediate Response against Bacterial Infection. Cell. 178: 1176-1188.e15. PMID 31442406 DOI: 10.1016/J.Cell.2019.07.032  0.376
2019 Solis AG, Bielecki P, Steach HR, Sharma L, Harman CCD, Yun S, de Zoete MR, Warnock JN, To SDF, York AG, Mack M, Schwartz MA, Dela Cruz CS, Palm NW, Jackson R, ... Flavell RA, et al. Mechanosensation of cyclical force by PIEZO1 is essential for innate immunity. Nature. PMID 31435009 DOI: 10.1038/S41586-019-1485-8  0.332
2019 Bailis W, Shyer JA, Zhao J, Canaveras JCG, Al Khazal FJ, Qu R, Steach HR, Bielecki P, Khan O, Jackson R, Kluger Y, Maher LJ, Rabinowitz J, Craft J, Flavell RA. Distinct modes of mitochondrial metabolism uncouple T cell differentiation and function. Nature. PMID 31217581 DOI: 10.1038/S41586-019-1311-3  0.362
2019 Cella M, Gamini R, Sécca C, Collins PL, Zhao S, Peng V, Robinette ML, Schettini J, Zaitsev K, Gordon W, Bando JK, Yomogida K, Cortez V, Fronick C, Fulton R, ... ... Flavell RA, et al. Subsets of ILC3-ILC1-like cells generate a diversity spectrum of innate lymphoid cells in human mucosal tissues. Nature Immunology. PMID 31209406 DOI: 10.1038/S41590-019-0425-Y  0.341
2019 Grootjans J, Krupka N, Hosomi S, Matute JD, Hanley T, Saveljeva S, Gensollen T, Heijmans J, Li H, Limenitakis JP, Ganal-Vonarburg SC, Suo S, Luoma AM, Shimodaira Y, Duan J, ... ... Flavell RA, et al. Epithelial endoplasmic reticulum stress orchestrates a protective IgA response. Science (New York, N.Y.). 363: 993-998. PMID 30819965 DOI: 10.1126/Science.Aat7186  0.309
2019 Gbyli R, Song Y, Liu W, Gao Y, Chandhok NS, Fu X, Wang X, Patel A, Sundaram R, Tebaldi T, Biancon G, Ardasheva A, Qin A, Sadykov M, Mamillapalli P, ... Flavell R, et al. PARP Inhibitors Are Effective in IDH1/2 Mutant MDS and AML Resistant to Targeted IDH Inhibitors Blood. 134: 4222-4222. DOI: 10.1182/Blood-2019-130814  0.302
2019 Song Y, Shan L, Gbyli R, Liu W, Fu X, Wang X, Qin A, Patel A, Gao Y, Tebaldi T, Biancon G, Urbonas D, Alderman J, Halene S, Flavell R. In Vivo reconstruction of Human Erythropoiesis with Circulating Mature Human RBCs in Humanized Liver Mistrg Mice Blood. 134: 338-338. DOI: 10.1182/Blood-2019-130701  0.312
2019 Gao Y, Vasic R, Song Y, Teng R, Gbyli R, Biancon G, Nelakanti R, Kudo E, Liu W, Ardasheva A, Fu X, Wang X, Joshi P, Dura B, Lee V, ... ... Flavell R, et al. Loss of METTL3 Mediated m6A RNA Modification Results in Double-Stranded RNA Induced Innate Immune Response and Hematopoietic Failure Blood. 134: 450-450. DOI: 10.1182/Blood-2019-130442  0.361
2018 Brockmann L, Soukou S, Steglich B, Czarnewski P, Zhao L, Wende S, Bedke T, Ergen C, Manthey C, Agalioti T, Geffken M, Seiz O, Parigi SM, Sorini C, Geginat J, ... ... Flavell RA, et al. Molecular and functional heterogeneity of IL-10-producing CD4 T cells. Nature Communications. 9: 5457. PMID 30575716 DOI: 10.1038/S41467-018-07581-4  0.387
2018 Ding S, Zhu S, Ren L, Feng N, Song Y, Ge X, Li B, Flavell RA, Greenberg HB. Rotavirus VP3 targets MAVS for degradation to inhibit type III interferon expression in intestinal epithelial cells. Elife. 7. PMID 30460894 DOI: 10.7554/Elife.39494  0.343
2018 Mathies F, Steffens N, Kleinschmidt D, Stuhlmann F, Huber FJ, Roy U, Meyer T, Luetgehetmann M, von Petersdorff M, Seiz O, Herkel J, Schramm C, Flavell RA, Gagliani N, Krebs C, et al. Colitis Promotes a Pathological Condition of the Liver in the Absence of Foxp3 Regulatory T Cells. Journal of Immunology (Baltimore, Md. : 1950). PMID 30446566 DOI: 10.4049/Jimmunol.1800711  0.325
2018 Chen HM, van der Touw W, Wang YS, Kang K, Mai S, Zhang J, Alsina-Beauchamp D, Duty JA, Mungamuri SK, Zhang B, Moran T, Flavell R, Aaronson S, Hu HM, Arase H, et al. Blocking immunoinhibitory receptor LILRB2 reprograms tumor-associated myeloid cells and promotes antitumor immunity. The Journal of Clinical Investigation. PMID 30352428 DOI: 10.1172/Jci97570  0.358
2018 Tye H, Yu CH, Simms LA, de Zoete MR, Kim ML, Zakrzewski M, Penington JS, Harapas CR, Souza-Fonseca-Guimaraes F, Wockner LF, Preaudet A, Mielke LA, Wilcox SA, Ogura Y, Corr SC, ... ... Flavell RA, et al. NLRP1 restricts butyrate producing commensals to exacerbate inflammatory bowel disease. Nature Communications. 9: 3728. PMID 30214011 DOI: 10.1038/S41467-018-06125-0  0.368
2018 Shehata HM, Khan S, Chen E, Fields PE, Flavell RA, Sanjabi S. Lack of Sprouty 1 and 2 enhances survival of effector CD8 T cells and yields more protective memory cells. Proceedings of the National Academy of Sciences of the United States of America. PMID 30126987 DOI: 10.1073/Pnas.1808320115  0.349
2018 Diefenhardt P, Nosko A, Kluger MA, Richter JV, Wegscheid C, Kobayashi Y, Tiegs G, Huber S, Flavell RA, Stahl RAK, Steinmetz OM. IL-10 Receptor Signaling Empowers Regulatory T Cells to Control Th17 Responses and Protect from GN. Journal of the American Society of Nephrology : Jasn. PMID 29866800 DOI: 10.1681/Asn.2017091044  0.372
2018 Herndler-Brandstetter D, Ishigame H, Shinnakasu R, Plajer V, Stecher C, Zhao J, Lietzenmayer M, Kroehling L, Takumi A, Kometani K, Inoue T, Kluger Y, Kaech SM, Kurosaki T, Okada T, ... Flavell RA, et al. KLRG1 Effector CD8 T Cells Lose KLRG1, Differentiate into All Memory T Cell Lineages, and Convey Enhanced Protective Immunity. Immunity. 48: 716-729.e8. PMID 29625895 DOI: 10.1016/J.Immuni.2018.03.015  0.333
2018 Emgård J, Kammoun H, García-Cassani B, Chesné J, Parigi SM, Jacob JM, Cheng HW, Evren E, Das S, Czarnewski P, Sleiers N, Melo-Gonzalez F, Kvedaraite E, Svensson M, Scandella E, ... ... Flavell RA, et al. Oxysterol Sensing through the Receptor GPR183 Promotes the Lymphoid-Tissue-Inducing Function of Innate Lymphoid Cells and Colonic Inflammation. Immunity. 48: 120-132.e8. PMID 29343433 DOI: 10.1016/J.Immuni.2017.11.020  0.333
2018 Gao Y, Vasic R, Tebaldi T, Song Y, Teng R, Joshi P, Viero G, Xiao A, Batista P, Li H, Flavell R, Halene S. Mettl3 Mediated m6A Modification Is Essential in Fetal Hematopoiesis Blood. 132: 3825-3825. DOI: 10.1182/Blood-2018-99-119699  0.358
2017 Rongvaux A, Willinger T, Martinek J, Strowig T, Gearty SV, Teichmann LL, Saito Y, Marches F, Halene S, Palucka AK, Manz MG, Flavell RA. Corrigendum: Development and function of human innate immune cells in a humanized mouse model. Nature Biotechnology. 35: 1211. PMID 29220023 DOI: 10.1038/Nbt1217-1211C  0.304
2017 Ring NG, Herndler-Brandstetter D, Weiskopf K, Shan L, Volkmer JP, George BM, Lietzenmayer M, McKenna KM, Naik TJ, McCarty A, Zheng Y, Ring AM, Flavell RA, Weissman IL. Anti-SIRPα antibody immunotherapy enhances neutrophil and macrophage antitumor activity. Proceedings of the National Academy of Sciences of the United States of America. PMID 29158380 DOI: 10.1073/Pnas.1710877114  0.314
2017 Yu H, Paiva R, Flavell RA. Harnessing the power of regulatory T cells to control autoimmune diabetes: overview and perspective. Immunology. PMID 29155454 DOI: 10.1111/Imm.12867  0.386
2017 Kleinschmidt D, Giannou AD, McGee HM, Kempski J, Steglich B, Huber FJ, Ernst TM, Shiri AM, Wegscheid C, Tasika E, Hübener P, Huber P, Bedke T, Steffens N, Agalioti T, ... ... Flavell RA, et al. A Protective Function of IL-22BP in Ischemia Reperfusion and Acetaminophen-Induced Liver Injury. Journal of Immunology (Baltimore, Md. : 1950). PMID 29109123 DOI: 10.4049/Jimmunol.1700587  0.602
2017 Herndler-Brandstetter D, Shan L, Yao Y, Stecher C, Plajer V, Lietzenmayer M, Strowig T, de Zoete MR, Palm NW, Chen J, Blish CA, Frleta D, Gurer C, Macdonald LE, Murphy AJ, ... ... Flavell RA, et al. Humanized mouse model supports development, function, and tissue residency of human natural killer cells. Proceedings of the National Academy of Sciences of the United States of America. PMID 29078283 DOI: 10.1073/Pnas.1705301114  0.352
2017 Roy U, Gálvez EJC, Iljazovic A, Lesker TR, Błażejewski AJ, Pils MC, Heise U, Huber S, Flavell RA, Strowig T. Distinct Microbial Communities Trigger Colitis Development upon Intestinal Barrier Damage via Innate or Adaptive Immune Cells. Cell Reports. 21: 994-1008. PMID 29069606 DOI: 10.1016/J.Celrep.2017.09.097  0.328
2017 Shan L, Deng K, Gao H, Xing S, Capoferri AA, Durand CM, Rabi SA, Laird GM, Kim M, Hosmane NN, Yang HC, Zhang H, Margolick JB, Li L, Cai W, ... ... Flavell RA, et al. Transcriptional Reprogramming during Effector-to-Memory Transition Renders CD4(+) T Cells Permissive for Latent HIV-1 Infection. Immunity. 47: 766-775.e3. PMID 29045905 DOI: 10.1016/J.Immuni.2017.09.014  0.306
2017 Mowel WK, McCright SJ, Kotzin JJ, Collet MA, Uyar A, Chen X, DeLaney A, Spencer SP, Virtue AT, Yang E, Villarino A, Kurachi M, Dunagin MC, Pritchard GH, Stein J, ... ... Flavell RA, et al. Group 1 Innate Lymphoid Cell Lineage Identity Is Determined by a cis-Regulatory Element Marked by a Long Non-coding RNA. Immunity. 47: 435-449.e8. PMID 28930659 DOI: 10.1016/J.Immuni.2017.08.012  0.324
2017 Rivera Vargas T, Cai Z, Shen Y, Dosset M, Benoit-Lizon I, Martin T, Roussey A, Flavell RA, Ghiringhelli F, Apetoh L. Selective degradation of PU.1 during autophagy represses the differentiation and antitumour activity of TH9 cells. Nature Communications. 8: 559. PMID 28916785 DOI: 10.1038/S41467-017-00468-W  0.403
2017 Yu H, Gagliani N, Ishigame H, Huber S, Zhu S, Esplugues E, Herold KC, Wen L, Flavell RA. Intestinal type 1 regulatory T cells migrate to periphery to suppress diabetogenic T cells and prevent diabetes development. Proceedings of the National Academy of Sciences of the United States of America. PMID 28894001 DOI: 10.1073/Pnas.1705599114  0.383
2017 Pan W, Zhu S, Qu K, Meeth K, Cheng J, He K, Ma H, Liao Y, Wen X, Roden C, Tobiasova Z, Wei Z, Zhao J, Liu J, Zheng J, ... ... Flavell RA, et al. The DNA Methylcytosine Dioxygenase Tet2 Sustains Immunosuppressive Function of Tumor-Infiltrating Myeloid Cells to Promote Melanoma Progression. Immunity. 47: 284-297.e5. PMID 28813659 DOI: 10.1016/J.Immuni.2017.07.020  0.335
2017 Li HB, Tong J, Zhu S, Batista PJ, Duffy EE, Zhao J, Bailis W, Cao G, Kroehling L, Chen Y, Wang G, Broughton JP, Chen YG, Kluger Y, Simon MD, ... ... Flavell RA, et al. m(6)A mRNA methylation controls T cell homeostasis by targeting the IL-7/STAT5/SOCS pathways. Nature. PMID 28792938 DOI: 10.1038/Nature23450  0.374
2017 Cunha LD, Silva ALN, Ribeiro JM, Mascarenhas DPA, Quirino GFS, Santos LL, Flavell RA, Zamboni DS. AIM2 Engages Active but Unprocessed Caspase-1 to Induce Noncanonical Activation of the NLRP3 Inflammasome. Cell Reports. 20: 794-805. PMID 28746866 DOI: 10.1016/J.Celrep.2017.06.086  0.314
2017 Cao G, Wang Q, Huang W, Tong J, Ye D, He Y, Liu Z, Tang X, Cheng H, Wen Q, Li D, Chau HT, Wen Y, Zhong H, Meng Z, ... ... Flavell RA, et al. Long-term consumption of caffeine-free high sucrose cola beverages aggravates the pathogenesis of EAE in mice. Cell Discovery. 3: 17020. PMID 28670480 DOI: 10.1038/Celldisc.2017.20  0.313
2017 Zhu S, Ding S, Wang P, Wei Z, Pan W, Palm NW, Yang Y, Yu H, Li HB, Wang G, Lei X, de Zoete MR, Zhao J, Zheng Y, Chen H, ... ... Flavell RA, et al. Nlrp9b inflammasome restricts rotavirus infection in intestinal epithelial cells. Nature. PMID 28636595 DOI: 10.1038/Nature22967  0.363
2017 Thiemann S, Smit N, Roy U, Lesker TR, Gálvez EJC, Helmecke J, Basic M, Bleich A, Goodman AL, Kalinke U, Flavell RA, Erhardt M, Strowig T. Enhancement of IFNγ Production by Distinct Commensals Ameliorates Salmonella-Induced Disease. Cell Host & Microbe. 21: 682-694.e5. PMID 28618267 DOI: 10.1016/J.Chom.2017.05.005  0.345
2017 Bosurgi L, Cao YG, Cabeza-Cabrerizo M, Tucci A, Hughes LD, Kong Y, Weinstein JS, Licona-Limon P, Schmid ET, Pelorosso F, Gagliani N, Craft JE, Flavell RA, Ghosh S, Rothlin CV. Macrophage function in tissue repair and remodeling requires IL-4 or IL-13 with apoptotic cells. Science (New York, N.Y.). PMID 28495875 DOI: 10.1126/Science.Aai8132  0.344
2017 Speir M, Vogrin A, Seidi A, Abraham G, Hunot S, Han Q, Dorn GW, Masters SL, Flavell RA, Vince JE, Naderer T. Legionella pneumophila Strain 130b Evades Macrophage Cell Death Independent of the Effector SidF in the Absence of Flagellin. Frontiers in Cellular and Infection Microbiology. 7: 35. PMID 28261564 DOI: 10.3389/Fcimb.2017.00035  0.548
2017 Nowarski R, Jackson R, Flavell RA. The Stromal Intervention: Regulation of Immunity and Inflammation at the Epithelial-Mesenchymal Barrier. Cell. 168: 362-375. PMID 28129537 DOI: 10.1016/J.Cell.2016.11.040  0.327
2017 Yu H, Borsotti C, Schickel JN, Zhu S, Strowig T, Eynon EE, Frleta D, Gurer C, Murphy AJ, Yancopoulos GD, Meffre E, Manz MG, Flavell RA. A novel humanized mouse model with significant improvement of class- switched, antigen-specific antibody production. Blood. PMID 28077418 DOI: 10.1182/Blood-2016-04-709584  0.372
2016 Brockmann L, Gagliani N, Steglich B, Giannou AD, Kempski J, Pelczar P, Geffken M, Mfarrej B, Huber F, Herkel J, Wan YY, Esplugues E, Battaglia M, Krebs CF, Flavell RA, et al. IL-10 Receptor Signaling Is Essential for TR1 Cell Function In Vivo. Journal of Immunology (Baltimore, Md. : 1950). PMID 28003377 DOI: 10.4049/Jimmunol.1601045  0.384
2016 Schickel JN, Kuhny M, Baldo A, Bannock JM, Massad C, Wang H, Katz N, Oe T, Menard L, Soulas-Sprauel P, Strowig T, Flavell R, Meffre E. PTPN22 inhibition resets defective human central B cell tolerance. Science Immunology. 1. PMID 27917411 DOI: 10.1126/Sciimmunol.Aaf7153  0.358
2016 Cordeiro Gomes A, Hara T, Lim VY, Herndler-Brandstetter D, Nevius E, Sugiyama T, Tani-Ichi S, Schlenner S, Richie E, Rodewald HR, Flavell RA, Nagasawa T, Ikuta K, Pereira JP. Hematopoietic Stem Cell Niches Produce Lineage-Instructive Signals to Control Multipotent Progenitor Differentiation. Immunity. PMID 27913094 DOI: 10.1016/J.Immuni.2016.11.004  0.331
2016 Hu B, Jin C, Li HB, Tong J, Ouyang X, Cetinbas NM, Zhu S, Strowig T, Lam FC, Zhao C, Henao-Mejia J, Yilmaz O, Fitzgerald KA, Eisenbarth SC, Elinav E, ... Flavell RA, et al. The DNA-sensing AIM2 inflammasome controls radiation-induced cell death and tissue injury. Science (New York, N.Y.). 354: 765-768. PMID 27846608 DOI: 10.1126/Science.Aaf7532  0.301
2016 Pelczar P, Witkowski M, Perez LG, Kempski J, Hammel AG, Brockmann L, Kleinschmidt D, Wende S, Haueis C, Bedke T, Witkowski M, Krasemann S, Steurer S, Booth CJ, Busch P, ... ... Flavell RA, et al. A pathogenic role for T cell-derived IL-22BP in inflammatory bowel disease. Science (New York, N.Y.). 354: 358-362. PMID 27846573 DOI: 10.1126/Science.Aah5903  0.358
2016 Paul AM, Acharya D, Le L, Wang P, Stokic DS, Leis AA, Alexopoulou L, Town T, Flavell RA, Fikrig E, Bai F. TLR8 Couples SOCS-1 and Restrains TLR7-Mediated Antiviral Immunity, Exacerbating West Nile Virus Infection in Mice. Journal of Immunology (Baltimore, Md. : 1950). PMID 27798161 DOI: 10.4049/Jimmunol.1600902  0.586
2016 Acharya D, Wang P, Paul AM, Dai J, Gate D, Lowery JE, Stokic DS, Leis AA, Flavell RA, Town T, Fikrig E, Bai F. Interleukin-17A Promotes CD8+ T Cell Cytotoxicity to Facilitate West Nile Virus Clearance. Journal of Virology. PMID 27795421 DOI: 10.1128/Jvi.01529-16  0.768
2016 Shen X, Burguillos MA, Osman AM, Frijhoff J, Carrillo-Jiménez A, Kanatani S, Augsten M, Saidi D, Rodhe J, Kavanagh E, Rongvaux A, Rraklli V, Nyman U, Holmberg J, Östman A, ... Flavell RA, et al. Glioma-induced inhibition of caspase-3 in microglia promotes a tumor-supportive phenotype. Nature Immunology. PMID 27618552 DOI: 10.1038/Ni.3545  0.315
2016 Boddupalli CS, Nair S, Gray SM, Nowyhed HN, Verma R, Gibson JA, Abraham C, Narayan D, Vasquez J, Hedrick CC, Flavell RA, Dhodapkar KM, Kaech SM, Dhodapkar MV. ABC transporters and NR4A1 identify a quiescent subset of tissue-resident memory T cells. The Journal of Clinical Investigation. PMID 27617863 DOI: 10.1172/Jci85329  0.373
2016 Ellegast JM, Rauch PJ, Kovtonyuk LV, Müller R, Wagner U, Saito Y, Wildner-Verhey van Wijk N, Fritz C, Rafiei A, Lysenko V, Dudkiewicz E, Theocharides AP, Soldini D, Goede JS, Flavell RA, et al. INV(16) and NPM1mut AML engraft human cytokine knock-in mice. Blood. PMID 27581357 DOI: 10.1182/Blood-2015-12-689356  0.319
2016 Weinstein JS, Herman EI, Lainez B, Licona-Limón P, Esplugues E, Flavell R, Craft J. TFH cells progressively differentiate to regulate the germinal center response. Nature Immunology. PMID 27573866 DOI: 10.1038/Ni.3554  0.38
2016 Saito Y, Ellegast JM, Rafiei A, Song Y, Kull D, Heikenwalder M, Rongvaux A, Halene S, Flavell RA, Manz MG. Peripheral blood CD34+ cells efficiently engraft human cytokine knock-in mice. Blood. PMID 27543436 DOI: 10.1182/Blood-2015-10-676452  0.324
2016 Kotzin JJ, Spencer SP, McCright SJ, Kumar DB, Collet MA, Mowel WK, Elliott EN, Uyar A, Makiya MA, Dunagin MC, Harman CC, Virtue AT, Zhu S, Bailis W, Stein J, ... ... Flavell RA, et al. The long non-coding RNA Morrbid regulates Bim and short-lived myeloid cell lifespan. Nature. PMID 27525555 DOI: 10.1038/Nature19346  0.344
2016 Campisi L, Barbet G, Ding Y, Esplugues E, Flavell RA, Blander JM. Apoptosis in response to microbial infection induces autoreactive TH17 cells. Nature Immunology. PMID 27455420 DOI: 10.1038/Ni.3512  0.353
2016 Costa FR, Françozo MC, de Oliveira GG, Ignacio A, Castoldi A, Zamboni DS, Ramos SG, Câmara NO, de Zoete MR, Palm NW, Flavell RA, Silva JS, Carlos D. Gut microbiota translocation to the pancreatic lymph nodes triggers NOD2 activation and contributes to T1D onset. The Journal of Experimental Medicine. PMID 27325889 DOI: 10.1084/Jem.20150744  0.354
2016 Krebs CF, Turner JE, Paust HJ, Kapffer S, Koyro T, Krohn S, Ufer F, Friese MA, Flavell RA, Stockinger B, Steinmetz OM, Stahl RA, Huber S, Panzer U. Plasticity of Th17 Cells in Autoimmune Kidney Diseases. Journal of Immunology (Baltimore, Md. : 1950). PMID 27271566 DOI: 10.4049/Jimmunol.1501831  0.393
2016 Hwang SS, Kim LK, Lee GR, Flavell RA. Role of OCT-1 and partner proteins in T cell differentiation. Biochimica Et Biophysica Acta. PMID 27126747 DOI: 10.1016/J.Bbagrm.2016.04.006  0.374
2016 Pillai PS, Molony RD, Martinod K, Dong H, Pang IK, Tal MC, Solis AG, Bielecki P, Mohanty S, Trentalange M, Homer RJ, Flavell RA, Wagner DD, Montgomery RR, Shaw AC, et al. Mx1 reveals innate pathways to antiviral resistance and lethal influenza disease. Science (New York, N.Y.). 352: 463-6. PMID 27102485 DOI: 10.1126/Science.Aaf3926  0.327
2016 Chan PY, Carrera Silva EA, De Kouchkovsky D, Joannas LD, Hao L, Hu D, Huntsman S, Eng C, Licona-Limón P, Weinstein JS, Herbert DR, Craft JE, Flavell RA, Repetto S, Correale J, et al. The TAM family receptor tyrosine kinase TYRO3 is a negative regulator of type 2 immunity. Science (New York, N.Y.). 352: 99-103. PMID 27034374 DOI: 10.1126/Science.Aaf1358  0.363
2016 Hwang SS, Jang SW, Kim MK, Kim LK, Kim BS, Kim HS, Kim K, Lee W, Flavell RA, Lee GR. YY1 inhibits differentiation and function of regulatory T cells by blocking Foxp3 expression and activity. Nature Communications. 7: 10789. PMID 26892542 DOI: 10.1038/Ncomms10789  0.385
2016 Bailis W, Harman C, Henao-Mejia J, Williams A, Goff L, Rinn J, Flavell R. Abstract A071: Identification and characterization of long intergenic non-coding RNAs (lincRNAs) governing T cell development and function Cancer Immunology Research. 4. DOI: 10.1158/2326-6066.Imm2016-A071  0.34
2015 Hong E, Usiskin IM, Bergamaschi C, Hanlon DJ, Edelson RL, Justesen S, Pavlakis GN, Flavell RA, Fahmy TM. Configuration-dependent presentation of multivalent IL-15:IL-15Rα enhances the antigen-specific T cell response and anti-tumor immunity. The Journal of Biological Chemistry. PMID 26719339 DOI: 10.1074/Jbc.M115.695304  0.325
2015 Nowarski R, Jackson R, Gagliani N, de Zoete MR, Palm NW, Bailis W, Low JS, Harman CC, Graham M, Elinav E, Flavell RA. Epithelial IL-18 Equilibrium Controls Barrier Function in Colitis. Cell. 163: 1444-56. PMID 26638073 DOI: 10.1016/J.Cell.2015.10.072  0.364
2015 Levy M, Thaiss CA, Zeevi D, Dohnalová L, Zilberman-Schapira G, Mahdi JA, David E, Savidor A, Korem T, Herzig Y, Pevsner-Fischer M, Shapiro H, Christ A, Harmelin A, Halpern Z, ... ... Flavell RA, et al. Microbiota-Modulated Metabolites Shape the Intestinal Microenvironment by Regulating NLRP6 Inflammasome Signaling. Cell. 163: 1428-43. PMID 26638072 DOI: 10.1016/J.Cell.2015.10.048  0.304
2015 Paterka M, Siffrin V, Voss JO, Werr J, Hoppmann N, Gollan R, Belikan P, Bruttger J, Birkenstock J, Jung S, Esplugues E, Yogev N, Flavell RA, Bopp T, Zipp F. Gatekeeper role of brain antigen-presenting CD11c+ cells in neuroinflammation. The Embo Journal. PMID 26612827 DOI: 10.15252/Embj.201591488  0.387
2015 Eisenbarth SC, Williams A, Colegio OR, Meng H, Strowig T, Rongvaux A, Henao-Mejia J, Thaiss CA, Joly S, Gonzalez DG, Xu L, Zenewicz LA, Haberman AM, Elinav E, Kleinstein SH, ... ... Flavell RA, et al. Corrigendum: NLRP10 is a NOD-like receptor essential to initiate adaptive immunity by dendritic cells. Nature. PMID 26605525 DOI: 10.1038/Nature16074  0.313
2015 Wang P, Zhu S, Yang L, Cui S, Pan W, Jackson R, Zheng Y, Rongvaux A, Sun Q, Yang G, Gao S, Lin R, You F, Flavell R, Fikrig E. Nlrp6 regulates intestinal antiviral innate immunity. Science (New York, N.Y.). PMID 26494172 DOI: 10.1126/Science.Aab3145  0.33
2015 Jha A, Singh AK, Weissgerber P, Freichel M, Flockerzi V, Flavell RA, Jha MK. Essential roles for Cavβ2 and Cav1 channels in thymocyte development and T cell homeostasis. Science Signaling. 8: ra103. PMID 26486172 DOI: 10.1126/Scisignal.Aac7538  0.324
2015 Finethy R, Jorgensen I, Haldar AK, de Zoete MR, Strowig T, Flavell RA, Yamamoto M, Nagarajan UM, Miao EA, Coers J. Guanylate Binding Proteins Enable Rapid Activation of Canonical and Noncanonical Inflammasomes in Chlamydia-Infected Macrophages. Infection and Immunity. 83: 4740-9. PMID 26416908 DOI: 10.1128/Iai.00856-15  0.356
2015 Facciotti F, Gagliani N, Häringer B, Alfen JS, Penatti A, Maglie S, Paroni M, Iseppon A, Moro M, Crosti MC, Stölzel K, Romagnani C, Moroni G, Ingegnoli F, Torretta S, ... ... Flavell R, et al. IL-10-producing forkhead box protein 3-negative regulatory T cells inhibit B-cell responses and are involved in systemic lupus erythematosus. The Journal of Allergy and Clinical Immunology. PMID 26318071 DOI: 10.1016/J.Jaci.2015.06.044  0.358
2015 Hu C, Ding H, Li Y, Pearson JA, Zhang X, Flavell RA, Wong FS, Wen L. NLRP3 deficiency protects from type 1 diabetes through the regulation of chemotaxis into the pancreatic islets. Proceedings of the National Academy of Sciences of the United States of America. PMID 26305961 DOI: 10.1073/Pnas.1513509112  0.374
2015 Jones A, Opejin A, Henderson JG, Gross C, Jain R, Epstein JA, Flavell RA, Hawiger D. Peripherally Induced Tolerance Depends on Peripheral Regulatory T Cells That Require Hopx To Inhibit Intrinsic IL-2 Expression. Journal of Immunology (Baltimore, Md. : 1950). PMID 26170384 DOI: 10.4049/Jimmunol.1500174  0.398
2015 Laidlaw BJ, Cui W, Amezquita RA, Gray SM, Guan T, Lu Y, Kobayashi Y, Flavell RA, Kleinstein SH, Craft J, Kaech SM. Production of IL-10 by CD4(+) regulatory T cells during the resolution of infection promotes the maturation of memory CD8(+) T cells. Nature Immunology. PMID 26147684 DOI: 10.1038/Ni.3224  0.374
2015 Cardona M, López JA, Serafín A, Rongvaux A, Inserte J, García-Dorado D, Flavell R, Llovera M, Cañas X, Vázquez J, Sanchis D. Executioner Caspase-3 and 7 Deficiency Reduces Myocyte Number in the Developing Mouse Heart. Plos One. 10: e0131411. PMID 26121671 DOI: 10.1371/Journal.Pone.0131411  0.31
2015 Kim LK, Morita R, Kobayashi Y, Eisenbarth SC, Lee CG, Elias J, Eynon EE, Flavell RA. AMCase is a crucial regulator of type 2 immune responses to inhaled house dust mites. Proceedings of the National Academy of Sciences of the United States of America. 112: E2891-9. PMID 26038565 DOI: 10.1073/Pnas.1507393112  0.359
2015 Gagliani N, Vesely MC, Iseppon A, Brockmann L, Xu H, Palm NW, de Zoete MR, Licona-Limón P, Paiva RS, Ching T, Weaver C, Zi X, Pan X, Fan R, Garmire LX, ... ... Flavell RA, et al. Th17 cells transdifferentiate into regulatory T cells during resolution of inflammation. Nature. 523: 221-5. PMID 25924064 DOI: 10.1038/Nature14452  0.403
2015 Willinger T, Staron M, Ferguson SM, De Camilli P, Flavell RA. Dynamin 2-dependent endocytosis sustains T-cell receptor signaling and drives metabolic reprogramming in T lymphocytes. Proceedings of the National Academy of Sciences of the United States of America. 112: 4423-8. PMID 25831514 DOI: 10.1073/Pnas.1504279112  0.355
2015 James SJ, Jiao H, Teh HY, Takahashi H, Png CW, Phoon MC, Suzuki Y, Sawasaki T, Xiao H, Chow VT, Yamamoto N, Reynolds JM, Flavell RA, Dong C, Zhang Y. MAPK Phosphatase 5 Expression Induced by Influenza and Other RNA Virus Infection Negatively Regulates IRF3 Activation and Type I Interferon Response. Cell Reports. PMID 25772359 DOI: 10.1016/J.Celrep.2015.02.030  0.322
2015 Png CW, Weerasooriya M, Guo J, James SJ, Poh HM, Osato M, Flavell RA, Dong C, Yang H, Zhang Y. DUSP10 regulates intestinal epithelial cell growth and colorectal tumorigenesis. Oncogene. PMID 25772234 DOI: 10.1038/Onc.2015.74  0.343
2015 Zorca CE, Kim LK, Kim YJ, Krause MR, Zenklusen D, Spilianakis CG, Flavell RA. Myosin VI regulates gene pairing and transcriptional pause release in T cells. Proceedings of the National Academy of Sciences of the United States of America. 112: E1587-93. PMID 25770220 DOI: 10.1073/Pnas.1502461112  0.787
2015 Stratigi K, Kapsetaki M, Aivaliotis M, Town T, Flavell RA, Spilianakis CG. Spatial proximity of homologous alleles and long noncoding RNAs regulate a switch in allelic gene expression. Proceedings of the National Academy of Sciences of the United States of America. 112: E1577-86. PMID 25770217 DOI: 10.1073/Pnas.1502182112  0.571
2015 Krishnaswamy JK, Singh A, Gowthaman U, Wu R, Gorrepati P, Sales Nascimento M, Gallman A, Liu D, Rhebergen AM, Calabro S, Xu L, Ranney P, Srivastava A, Ranson M, Gorham JD, ... ... Flavell RA, et al. Coincidental loss of DOCK8 function in NLRP10-deficient and C3H/HeJ mice results in defective dendritic cell migration. Proceedings of the National Academy of Sciences of the United States of America. 112: 3056-61. PMID 25713392 DOI: 10.1073/Pnas.1501554112  0.342
2015 Ballinger MN, Newstead MW, Zeng X, Bhan U, Mo XM, Kunkel SL, Moore BB, Flavell R, Christman JW, Standiford TJ. IRAK-M promotes alternative macrophage activation and fibroproliferation in bleomycin-induced lung injury. Journal of Immunology (Baltimore, Md. : 1950). 194: 1894-904. PMID 25595781 DOI: 10.4049/Jimmunol.1402377  0.324
2015 Galluzzi L, Bravo-San Pedro JM, Vitale I, Aaronson SA, Abrams JM, Adam D, Alnemri ES, Altucci L, Andrews D, Annicchiarico-Petruzzelli M, Baehrecke EH, Bazan NG, Bertrand MJ, Bianchi K, Blagosklonny MV, ... ... Flavell RA, et al. Essential versus accessory aspects of cell death: recommendations of the NCCD 2015. Cell Death and Differentiation. 22: 58-73. PMID 25236395 DOI: 10.1038/Cdd.2014.137  0.321
2015 Astle J, Xiang Y, Rongvaux A, Weibel C, Elizabeth H, Halene S, Park I, Flavell R. Developing a Model of Human Pluripotent to Hematopoietic Stem Cell Development in Mistrg Mice Blood. 126: 4755-4755. DOI: 10.1182/Blood.V126.23.4755.4755  0.322
2015 Song Y, Taylor A, Rongvaux A, Jiang T, Podoltsev NA, Xu M, Neparidze N, Torres R, Barbarotta LM, Balasubramanian K, Finberg KE, Kluger Y, Flavell R, Halene S. Efficient Engraftment and Disease Replication of Myelodysplastic Syndromes Using a Novel Humanized Mice Model Blood. 126: 4100-4100. DOI: 10.1182/Blood.V126.23.4100.4100  0.33
2015 Das R, Strowig T, Verma R, Koduru S, Hafemann A, Hopf S, Kocoglu MH, Borsotti C, Zhang L, Branagan AR, Eynon E, Manz M, Flavell R, Dhodapkar MV. Niche-Dependent Growth of Malignant and Pre-Neoplastic Plasma Cells in Humanized Mice Blood. 126: 120-120. DOI: 10.1182/Blood.V126.23.120.120  0.35
2014 Zhu S, Li HB, Flavell RA. Resemble and Inhibit: when RLR meets TGF-β. Molecular Cell. 56: 719-20. PMID 25526529 DOI: 10.1016/J.Molcel.2014.12.010  0.308
2014 Rongvaux A, Jackson R, Harman CC, Li T, West AP, de Zoete MR, Wu Y, Yordy B, Lakhani SA, Kuan CY, Taniguchi T, Shadel GS, Chen ZJ, Iwasaki A, Flavell RA. Apoptotic caspases prevent the induction of type I interferons by mitochondrial DNA. Cell. 159: 1563-77. PMID 25525875 DOI: 10.1016/J.Cell.2014.11.037  0.559
2014 Wegiel B, Larsen R, Gallo D, Chin BY, Harris C, Mannam P, Kaczmarek E, Lee PJ, Zuckerbraun BS, Flavell R, Soares MP, Otterbein LE. Macrophages sense and kill bacteria through carbon monoxide-dependent inflammasome activation. The Journal of Clinical Investigation. 124: 4926-40. PMID 25295542 DOI: 10.1172/Jci72853  0.33
2014 Bouwman LI, de Zoete MR, Bleumink-Pluym NM, Flavell RA, van Putten JP. Inflammasome activation by Campylobacter jejuni. Journal of Immunology (Baltimore, Md. : 1950). 193: 4548-57. PMID 25267974 DOI: 10.4049/Jimmunol.1400648  0.361
2014 Camirand G, Wang Y, Lu Y, Wan YY, Lin Y, Deng S, Guz G, Perkins DL, Finn PW, Farber DL, Flavell RA, Shlomchik WD, Lakkis FG, Rudd CE, Rothstein DM. CD45 ligation expands Tregs by promoting interactions with DCs. The Journal of Clinical Investigation. 124: 4603-13. PMID 25202978 DOI: 10.1172/Jci74087  0.358
2014 Shulman Z, Gitlin AD, Weinstein JS, Lainez B, Esplugues E, Flavell RA, Craft JE, Nussenzweig MC. Dynamic signaling by T follicular helper cells during germinal center B cell selection. Science (New York, N.Y.). 345: 1058-62. PMID 25170154 DOI: 10.1126/Science.1257861  0.335
2014 Gate D, Danielpour M, Rodriguez J, Kim GB, Levy R, Bannykh S, Breunig JJ, Kaech SM, Flavell RA, Town T. T-cell TGF-β signaling abrogation restricts medulloblastoma progression. Proceedings of the National Academy of Sciences of the United States of America. 111: E3458-66. PMID 25082897 DOI: 10.1073/Pnas.1412489111  0.767
2014 Chung LK, Philip NH, Schmidt VA, Koller A, Strowig T, Flavell RA, Brodsky IE, Bliska JB. IQGAP1 is important for activation of caspase-1 in macrophages and is targeted by Yersinia pestis type III effector YopM. Mbio. 5: e01402-14. PMID 24987096 DOI: 10.1128/Mbio.01402-14  0.316
2014 Sheppard NC, Brinckmann SA, Gartlan KH, Puthia M, Svanborg C, Krashias G, Eisenbarth SC, Flavell RA, Sattentau QJ, Wegmann F. Polyethyleneimine is a potent systemic adjuvant for glycoprotein antigens. International Immunology. 26: 531-8. PMID 24844701 DOI: 10.1093/Intimm/Dxu055  0.319
2014 Canaan A, DeFuria J, Perelman E, Schultz V, Seay M, Tuck D, Flavell RA, Snyder MP, Obin MS, Weissman SM. Extended lifespan and reduced adiposity in mice lacking the FAT10 gene. Proceedings of the National Academy of Sciences of the United States of America. 111: 5313-8. PMID 24706839 DOI: 10.1073/Pnas.1323426111  0.305
2014 Wynosky-Dolfi MA, Snyder AG, Philip NH, Doonan PJ, Poffenberger MC, Avizonis D, Zwack EE, Riblett AM, Hu B, Strowig T, Flavell RA, Jones RG, Freedman BD, Brodsky IE. Oxidative metabolism enables Salmonella evasion of the NLRP3 inflammasome. The Journal of Experimental Medicine. 211: 653-68. PMID 24638169 DOI: 10.1084/Jem.20130627  0.333
2014 Willinger T, Ferguson SM, Pereira JP, De Camilli P, Flavell RA. Dynamin 2-dependent endocytosis is required for sustained S1PR1 signaling. The Journal of Experimental Medicine. 211: 685-700. PMID 24638168 DOI: 10.1084/Jem.20131343  0.333
2014 Rongvaux A, Willinger T, Martinek J, Strowig T, Gearty SV, Teichmann LL, Saito Y, Marches F, Halene S, Palucka AK, Manz MG, Flavell RA. Development and function of human innate immune cells in a humanized mouse model. Nature Biotechnology. 32: 364-72. PMID 24633240 DOI: 10.1038/Nbt.2858  0.335
2014 Kim LK, Esplugues E, Zorca CE, Parisi F, Kluger Y, Kim TH, Galjart NJ, Flavell RA. Oct-1 regulates IL-17 expression by directing interchromosomal associations in conjunction with CTCF in T cells. Molecular Cell. 54: 56-66. PMID 24613343 DOI: 10.1016/J.Molcel.2014.02.004  0.791
2014 Wu X, Lahiri A, Haines GK, Flavell RA, Abraham C. NOD2 regulates CXCR3-dependent CD8+ T cell accumulation in intestinal tissues with acute injury. Journal of Immunology (Baltimore, Md. : 1950). 192: 3409-18. PMID 24591373 DOI: 10.4049/Jimmunol.1302436  0.383
2014 Wlodarska M, Thaiss CA, Nowarski R, Henao-Mejia J, Zhang JP, Brown EM, Frankel G, Levy M, Katz MN, Philbrick WM, Elinav E, Finlay BB, Flavell RA. NLRP6 inflammasome orchestrates the colonic host-microbial interface by regulating goblet cell mucus secretion. Cell. 156: 1045-59. PMID 24581500 DOI: 10.1016/J.Cell.2014.01.026  0.366
2014 Huang W, Kachapati K, Adams D, Wu Y, Leung PS, Yang GX, Zhang W, Ansari AA, Flavell RA, Gershwin ME, Ridgway WM. Murine autoimmune cholangitis requires two hits: cytotoxic KLRG1(+) CD8 effector cells and defective T regulatory cells. Journal of Autoimmunity. 50: 123-34. PMID 24556277 DOI: 10.1016/J.Jaut.2014.01.034  0.374
2014 Chen X, Shen Y, Liang Q, Flavell R, Hong Z, Yin Z, Wang M. Effect of Bavachinin and its derivatives on T cell differentiation. International Immunopharmacology. 19: 399-404. PMID 24508059 DOI: 10.1016/J.Intimp.2014.01.022  0.3
2014 Liu J, Harberts E, Tammaro A, Girardi N, Filler RB, Fishelevich R, Temann A, Licona-Limón P, Girardi M, Flavell RA, Gaspari AA. IL-9 regulates allergen-specific Th1 responses in allergic contact dermatitis. The Journal of Investigative Dermatology. 134: 1903-11. PMID 24487305 DOI: 10.1038/Jid.2014.61  0.349
2014 Liang X, Fu C, Cui W, Ober-Blöbaum JL, Zahner SP, Shrikant PA, Clausen BE, Flavell RA, Mellman I, Jiang A. β-catenin mediates tumor-induced immunosuppression by inhibiting cross-priming of CD8⁺ T cells. Journal of Leukocyte Biology. 95: 179-90. PMID 24023259 DOI: 10.1189/Jlb.0613330  0.345
2013 Nowarski R, Gagliani N, Huber S, Flavell RA. Innate immune cells in inflammation and cancer. Cancer Immunology Research. 1: 77-84. PMID 24777498 DOI: 10.1158/2326-6066.Cir-13-0081  0.311
2013 Ouyang X, Ghani A, Malik A, Wilder T, Colegio OR, Flavell RA, Cronstein BN, Mehal WZ. Adenosine is required for sustained inflammasome activation via the Aâ‚‚A receptor and the HIF-1α pathway. Nature Communications. 4: 2909. PMID 24352507 DOI: 10.1038/Ncomms3909  0.315
2013 Negishi H, Matsuki K, Endo N, Sarashina H, Miki S, Matsuda A, Fukazawa K, Taguchi-Atarashi N, Ikushima H, Yanai H, Nishio J, Honda K, Fujioka Y, Ohba Y, Noda T, ... ... Flavell RA, et al. Beneficial innate signaling interference for antibacterial responses by a Toll-like receptor-mediated enhancement of the MKP-IRF3 axis. Proceedings of the National Academy of Sciences of the United States of America. 110: 19884-9. PMID 24248350 DOI: 10.1073/Pnas.1320145110  0.55
2013 Richter K, Perriard G, Behrendt R, Schwendener RA, Sexl V, Dunn R, Kamanaka M, Flavell RA, Roers A, Oxenius A. Macrophage and T cell produced IL-10 promotes viral chronicity. Plos Pathogens. 9: e1003735. PMID 24244162 DOI: 10.1371/Journal.Ppat.1003735  0.388
2013 Chen X, Wen T, Wei J, Wu Z, Wang P, Hong Z, Zhao L, Wang B, Flavell R, Gao S, Wang M, Yin Z. Treatment of allergic inflammation and hyperresponsiveness by a simple compound, Bavachinin, isolated from Chinese herbs. Cellular & Molecular Immunology. 10: 497-505. PMID 24013845 DOI: 10.1038/Cmi.2013.27  0.333
2013 Gisterå A, Robertson AK, Andersson J, Ketelhuth DF, Ovchinnikova O, Nilsson SK, Lundberg AM, Li MO, Flavell RA, Hansson GK. Transforming growth factor-β signaling in T cells promotes stabilization of atherosclerotic plaques through an interleukin-17-dependent pathway. Science Translational Medicine. 5: 196ra100. PMID 23903754 DOI: 10.1126/Scitranslmed.3006133  0.39
2013 Elinav E, Thaiss CA, Flavell RA. Analysis of microbiota alterations in inflammasome-deficient mice. Methods in Molecular Biology (Clifton, N.J.). 1040: 185-94. PMID 23852605 DOI: 10.1007/978-1-62703-523-1_14  0.333
2013 Gagliani N, Jofra T, Valle A, Stabilini A, Morsiani C, Gregori S, Deng S, Rothstein DM, Atkinson M, Kamanaka M, Flavell RA, Roncarolo MG, Battaglia M. Transplant tolerance to pancreatic islets is initiated in the graft and sustained in the spleen. American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons. 13: 1963-75. PMID 23834659 DOI: 10.1111/Ajt.12333  0.353
2013 Zhao Y, Zhao H, Sun Y, Hao J, Qi X, Zhou X, Wu Z, Wang P, Kaech SM, Weaver CT, Flavell RA, Zhao L, Yao Z, Yin Z. IL-4 induces a suppressive IL-10-producing CD8+ T cell population via a Cdkn2a-dependent mechanism. Journal of Leukocyte Biology. 94: 1103-12. PMID 23772040 DOI: 10.1189/Jlb.0213064  0.381
2013 Casson CN, Copenhaver AM, Zwack EE, Nguyen HT, Strowig T, Javdan B, Bradley WP, Fung TC, Flavell RA, Brodsky IE, Shin S. Caspase-11 activation in response to bacterial secretion systems that access the host cytosol. Plos Pathogens. 9: e1003400. PMID 23762026 DOI: 10.1371/Journal.Ppat.1003400  0.347
2013 Lima-Junior DS, Costa DL, Carregaro V, Cunha LD, Silva AL, Mineo TW, Gutierrez FR, Bellio M, Bortoluci KR, Flavell RA, Bozza MT, Silva JS, Zamboni DS. Inflammasome-derived IL-1β production induces nitric oxide-mediated resistance to Leishmania. Nature Medicine. 19: 909-15. PMID 23749230 DOI: 10.1038/Nm.3221  0.324
2013 Hu B, Elinav E, Huber S, Strowig T, Hao L, Hafemann A, Jin C, Wunderlich C, Wunderlich T, Eisenbarth SC, Flavell RA. Microbiota-induced activation of epithelial IL-6 signaling links inflammasome-driven inflammation with transmissible cancer. Proceedings of the National Academy of Sciences of the United States of America. 110: 9862-7. PMID 23696660 DOI: 10.1073/Pnas.1307575110  0.356
2013 Licona-Limón P, Kim LK, Palm NW, Flavell RA. TH2, allergy and group 2 innate lymphoid cells. Nature Immunology. 14: 536-42. PMID 23685824 DOI: 10.1038/Ni.2617  0.355
2013 Ostmann A, Paust HJ, Panzer U, Wegscheid C, Kapffer S, Huber S, Flavell RA, Erhardt A, Tiegs G. Regulatory T cell-derived IL-10 ameliorates crescentic GN. Journal of the American Society of Nephrology : Jasn. 24: 930-42. PMID 23641052 DOI: 10.1681/Asn.2012070684  0.366
2013 Gagliani N, Magnani CF, Huber S, Gianolini ME, Pala M, Licona-Limon P, Guo B, Herbert DR, Bulfone A, Trentini F, Di Serio C, Bacchetta R, Andreani M, Brockmann L, Gregori S, ... Flavell RA, et al. Coexpression of CD49b and LAG-3 identifies human and mouse T regulatory type 1 cells. Nature Medicine. 19: 739-46. PMID 23624599 DOI: 10.1038/Nm.3179  0.363
2013 Williams A, Lee GR, Spilianakis CG, Hwang SS, Eisenbarth SC, Flavell RA. Hypersensitive site 6 of the Th2 locus control region is essential for Th2 cytokine expression. Proceedings of the National Academy of Sciences of the United States of America. 110: 6955-60. PMID 23569250 DOI: 10.1073/Pnas.1304720110  0.35
2013 Koni PA, Bolduc A, Takezaki M, Ametani Y, Huang L, Lee JR, Nutt SL, Kamanaka M, Flavell RA, Mellor AL, Tsubata T, Shimoda M. Constitutively CD40-activated B cells regulate CD8 T cell inflammatory response by IL-10 induction. Journal of Immunology (Baltimore, Md. : 1950). 190: 3189-96. PMID 23440421 DOI: 10.4049/Jimmunol.1203364  0.385
2013 Ye J, Llorian M, Cardona M, Rongvaux A, Moubarak RS, Comella JX, Bassel-Duby R, Flavell RA, Olson EN, Smith CW, Sanchis D. A pathway involving HDAC5, cFLIP and caspases regulates expression of the splicing regulator polypyrimidine tract binding protein in the heart. Journal of Cell Science. 126: 1682-91. PMID 23424201 DOI: 10.1242/Jcs.121384  0.311
2013 Martin RA, Ather JL, Lundblad LK, Suratt BT, Boyson JE, Budd RC, Alcorn JF, Flavell RA, Eisenbarth SC, Poynter ME. Interleukin-1 receptor and caspase-1 are required for the Th17 response in nitrogen dioxide-promoted allergic airway disease. American Journal of Respiratory Cell and Molecular Biology. 48: 655-64. PMID 23371061 DOI: 10.1165/Rcmb.2012-0423Oc  0.365
2013 Chaiyachati BH, Jani A, Wan Y, Huang H, Flavell R, Chi T. BRG1-mediated immune tolerance: facilitation of Treg activation and partial independence of chromatin remodelling. The Embo Journal. 32: 395-408. PMID 23321680 DOI: 10.1038/Emboj.2012.350  0.384
2013 Case CL, Kohler LJ, Lima JB, Strowig T, de Zoete MR, Flavell RA, Zamboni DS, Roy CR. Caspase-11 stimulates rapid flagellin-independent pyroptosis in response to Legionella pneumophila. Proceedings of the National Academy of Sciences of the United States of America. 110: 1851-6. PMID 23307811 DOI: 10.1073/Pnas.1211521110  0.314
2013 Terwagne M, Ferooz J, Rolán HG, Sun YH, Atluri V, Xavier MN, Franchi L, Núñez G, Legrand T, Flavell RA, De Bolle X, Letesson JJ, Tsolis RM. Innate immune recognition of flagellin limits systemic persistence of Brucella. Cellular Microbiology. 15: 942-60. PMID 23227931 DOI: 10.1111/Cmi.12088  0.349
2013 McGee HM, Schmidt BA, Booth CJ, Yancopoulos GD, Valenzuela DM, Murphy AJ, Stevens S, Flavell RA, Horsley V. IL-22 promotes fibroblast-mediated wound repair in the skin. The Journal of Investigative Dermatology. 133: 1321-9. PMID 23223145 DOI: 10.1038/Jid.2012.463  0.622
2013 Chaiyachati BH, Kaundal RK, Zhao J, Wu J, Flavell R, Chi T. LoxP-FRT Trap (LOFT): a simple and flexible system for conventional and reversible gene targeting. Bmc Biology. 10: 96. PMID 23198860 DOI: 10.1186/1741-7007-10-96  0.311
2013 Lievens D, Habets KL, Robertson AK, Laouar Y, Winkels H, Rademakers T, Beckers L, Wijnands E, Boon L, Mosaheb M, Ait-Oufella H, Mallat Z, Flavell RA, Rudling M, Binder CJ, et al. Abrogated transforming growth factor beta receptor II (TGFβRII) signalling in dendritic cells promotes immune reactivity of T cells resulting in enhanced atherosclerosis European Heart Journal. 34: 3717-3727. PMID 22613345 DOI: 10.1093/Eurheartj/Ehs106  0.356
2013 Tsuda M, Zhang W, Yang GX, Tsuneyama K, Ando Y, Kawata K, Park O, Leung PS, Coppel RL, Ansari AA, Ridgway WM, Gao B, Lian ZX, Flavell R, He XS, et al. Deletion of interleukin (IL)-12p35 induces liver fibrosis in dominant-negative TGFβ receptor type II mice. Hepatology (Baltimore, Md.). 57: 806-16. PMID 22576253 DOI: 10.1002/Hep.25829  0.36
2013 Casson CN, Copenhaver AM, Zwack EE, Nguyen HT, Strowig T, Javdan B, Bradley WP, Fung TC, Flavell RA, Brodsky IE, Shin S. 37 Cytokine. 63: 252. DOI: 10.1016/J.Cyto.2013.06.040  0.339
2012 Huber S, Gagliani N, Zenewicz LA, Huber FJ, Bosurgi L, Hu B, Hedl M, Zhang W, O'Connor W, Murphy AJ, Valenzuela DM, Yancopoulos GD, Booth CJ, Cho JH, Ouyang W, ... ... Flavell RA, et al. IL-22BP is regulated by the inflammasome and modulates tumorigenesis in the intestine. Nature. 491: 259-63. PMID 23075849 DOI: 10.1038/Nature11535  0.32
2012 Joly S, Eisenbarth SC, Olivier AK, Williams A, Kaplan DH, Cassel SL, Flavell RA, Sutterwala FS. Cutting edge: Nlrp10 is essential for protective antifungal adaptive immunity against Candida albicans. Journal of Immunology (Baltimore, Md. : 1950). 189: 4713-7. PMID 23071280 DOI: 10.4049/Jimmunol.1201715  0.354
2012 Hoshi N, Schenten D, Nish SA, Walther Z, Gagliani N, Flavell RA, Reizis B, Shen Z, Fox JG, Iwasaki A, Medzhitov R. MyD88 signalling in colonic mononuclear phagocytes drives colitis in IL-10-deficient mice. Nature Communications. 3: 1120. PMID 23047678 DOI: 10.1038/Ncomms2113  0.389
2012 Liu X, Yan X, Zhong B, Nurieva RI, Wang A, Wang X, Martin-Orozco N, Wang Y, Chang SH, Esplugues E, Flavell RA, Tian Q, Dong C. Bcl6 expression specifies the T follicular helper cell program in vivo. The Journal of Experimental Medicine. 209: 1841-52, S1-24. PMID 22987803 DOI: 10.1084/Jem.20120219  0.37
2012 Wang P, Bai F, Zenewicz LA, Dai J, Gate D, Cheng G, Yang L, Qian F, Yuan X, Montgomery RR, Flavell RA, Town T, Fikrig E. IL-22 signaling contributes to West Nile encephalitis pathogenesis. Plos One. 7: e44153. PMID 22952908 DOI: 10.1371/Journal.Pone.0044153  0.763
2012 Huber S, Gagliani N, Flavell RA. Life, death, and miracles: Th17 cells in the intestine. European Journal of Immunology. 42: 2238-45. PMID 22949322 DOI: 10.1002/Eji.201242619  0.364
2012 Wegmann F, Gartlan KH, Harandi AM, Brinckmann SA, Coccia M, Hillson WR, Kok WL, Cole S, Ho LP, Lambe T, Puthia M, Svanborg C, Scherer EM, Krashias G, Williams A, ... ... Flavell RA, et al. Polyethyleneimine is a potent mucosal adjuvant for viral glycoprotein antigens. Nature Biotechnology. 30: 883-8. PMID 22922673 DOI: 10.1038/Nbt.2344  0.325
2012 Gaddi PJ, Crane MJ, Kamanaka M, Flavell RA, Yap GS, Salazar-Mather TP. IL-10 mediated regulation of liver inflammation during acute murine cytomegalovirus infection. Plos One. 7: e42850. PMID 22880122 DOI: 10.1371/Journal.Pone.0042850  0.35
2012 Mandaric S, Walton SM, Rülicke T, Richter K, Girard-Madoux MJ, Clausen BE, Zurunic A, Kamanaka M, Flavell RA, Jonjic S, Oxenius A. IL-10 suppression of NK/DC crosstalk leads to poor priming of MCMV-specific CD4 T cells and prolonged MCMV persistence. Plos Pathogens. 8: e1002846. PMID 22876184 DOI: 10.1371/Journal.Ppat.1002846  0.393
2012 Dela Cruz CS, Liu W, He CH, Jacoby A, Gornitzky A, Ma B, Flavell R, Lee CG, Elias JA. Chitinase 3-like-1 promotes Streptococcus pneumoniae killing and augments host tolerance to lung antibacterial responses. Cell Host & Microbe. 12: 34-46. PMID 22817986 DOI: 10.1016/J.Chom.2012.05.017  0.319
2012 Park J, Wrzesinski SH, Stern E, Look M, Criscione J, Ragheb R, Jay SM, Demento SL, Agawu A, Licona Limon P, Ferrandino AF, Gonzalez D, Habermann A, Flavell RA, Fahmy TM. Combination delivery of TGF-β inhibitor and IL-2 by nanoscale liposomal polymeric gels enhances tumour immunotherapy. Nature Materials. 11: 895-905. PMID 22797827 DOI: 10.1038/Nmat3355  0.355
2012 Sukumaran B, Ogura Y, Pedra JH, Kobayashi KS, Flavell RA, Fikrig E. Receptor interacting protein-2 contributes to host defense against Anaplasma phagocytophilum infection. Fems Immunology and Medical Microbiology. 66: 211-9. PMID 22747758 DOI: 10.1111/J.1574-695X.2012.01001.X  0.366
2012 Hoogerwerf JJ, van der Windt GJ, Blok DC, Hoogendijk AJ, De Vos AF, van 't Veer C, Florquin S, Kobayashi KS, Flavell RA, van der Poll T. Interleukin-1 receptor-associated kinase M-deficient mice demonstrate an improved host defense during Gram-negative pneumonia. Molecular Medicine (Cambridge, Mass.). 18: 1067-75. PMID 22729155 DOI: 10.2119/Molmed.2011.00450  0.312
2012 Zhang W, Ferguson J, Ng SM, Hui K, Goh G, Lin A, Esplugues E, Flavell RA, Abraham C, Zhao H, Cho JH. Effector CD4+ T cell expression signatures and immune-mediated disease associated genes. Plos One. 7: e38510. PMID 22715389 DOI: 10.1371/Journal.Pone.0038510  0.387
2012 Walsh KB, Teijaro JR, Zuniga EI, Welch MJ, Fremgen DM, Blackburn SD, von Tiehl KF, Wherry EJ, Flavell RA, Oldstone MB. Toll-like receptor 7 is required for effective adaptive immune responses that prevent persistent virus infection. Cell Host & Microbe. 11: 643-53. PMID 22704624 DOI: 10.1016/J.Chom.2012.04.016  0.35
2012 Macal M, Lewis GM, Kunz S, Flavell R, Harker JA, Zúñiga EI. Plasmacytoid dendritic cells are productively infected and activated through TLR-7 early after arenavirus infection. Cell Host & Microbe. 11: 617-30. PMID 22704622 DOI: 10.1016/J.Chom.2012.04.017  0.32
2012 Bobr A, Igyarto BZ, Haley KM, Li MO, Flavell RA, Kaplan DH. Autocrine/paracrine TGF-β1 inhibits Langerhans cell migration Proceedings of the National Academy of Sciences of the United States of America. 109: 10492-10497. PMID 22689996 DOI: 10.1073/Pnas.1119178109  0.318
2012 Ballinger MN, Newstead MW, Zeng X, Bhan U, Horowitz JC, Moore BB, Pinsky DJ, Flavell RA, Standiford TJ. TLR signaling prevents hyperoxia-induced lung injury by protecting the alveolar epithelium from oxidant-mediated death. Journal of Immunology (Baltimore, Md. : 1950). 189: 356-64. PMID 22661086 DOI: 10.4049/Jimmunol.1103124  0.311
2012 Helbig C, Gentek R, Backer RA, de Souza Y, Derks IA, Eldering E, Wagner K, Jankovic D, Gridley T, Moerland PD, Flavell RA, Amsen D. Notch controls the magnitude of T helper cell responses by promoting cellular longevity. Proceedings of the National Academy of Sciences of the United States of America. 109: 9041-6. PMID 22615412 DOI: 10.1073/Pnas.1206044109  0.393
2012 Wu LH, Huang CC, Adhikarakunnathu S, San Mateo LR, Duffy KE, Rafferty P, Bugelski P, Raymond H, Deutsch H, Picha K, Ward CK, Alexoupolou L, Flavell RA, Mbow ML, Susulic VS. Loss of toll-like receptor 3 function improves glucose tolerance and reduces liver steatosis in obese mice. Metabolism: Clinical and Experimental. 61: 1633-45. PMID 22607770 DOI: 10.1016/J.Metabol.2012.04.015  0.303
2012 Czyzyk J, Henegariu O, Preston-Hurlburt P, Baldzizhar R, Fedorchuk C, Esplugues E, Bottomly K, Gorus FK, Herold K, Flavell RA. Enhanced anti-serpin antibody activity inhibits autoimmune inflammation in type 1 diabetes. Journal of Immunology (Baltimore, Md. : 1950). 188: 6319-27. PMID 22593614 DOI: 10.4049/Jimmunol.1200467  0.311
2012 Eisenbarth SC, Williams A, Colegio OR, Meng H, Strowig T, Rongvaux A, Henao-Mejia J, Thaiss CA, Joly S, Gonzalez DG, Xu L, Zenewicz LA, Haberman AM, Elinav E, Kleinstein SH, ... ... Flavell RA, et al. NLRP10 is a NOD-like receptor essential to initiate adaptive immunity by dendritic cells. Nature. 484: 510-3. PMID 22538615 DOI: 10.1038/Nature11012  0.361
2012 Kinnebrew MA, Buffie CG, Diehl GE, Zenewicz LA, Leiner I, Hohl TM, Flavell RA, Littman DR, Pamer EG. Interleukin 23 production by intestinal CD103(+)CD11b(+) dendritic cells in response to bacterial flagellin enhances mucosal innate immune defense. Immunity. 36: 276-87. PMID 22306017 DOI: 10.1016/J.Immuni.2011.12.011  0.373
2012 Waldron-Lynch F, Henegariu O, Deng S, Preston-Hurlburt P, Tooley J, Flavell R, Herold KC. Teplizumab induces human gut-tropic regulatory cells in humanized mice and patients. Science Translational Medicine. 4: 118ra12. PMID 22277969 DOI: 10.1126/Scitranslmed.3003401  0.372
2012 Strowig T, Henao-Mejia J, Elinav E, Flavell R. Inflammasomes in health and disease. Nature. 481: 278-86. PMID 22258606 DOI: 10.1038/Nature10759  0.335
2012 Koduru S, Wong E, Strowig T, Sundaram R, Zhang L, Strout MP, Flavell RA, Schatz DG, Dhodapkar KM, Dhodapkar MV. Dendritic cell-mediated activation-induced cytidine deaminase (AID)-dependent induction of genomic instability in human myeloma. Blood. 119: 2302-9. PMID 22234692 DOI: 10.1182/Blood-2011-08-376236  0.303
2012 Strowig T, Hafemann A, Hopf S, Sehgal K, Koduru S, Kocoglu MH, Das R, Dhodapkar MV, Flavell RA. Development of a Novel in Vivo Model for Human Myeloma Via Humanization of the Bone Marrow Niche Blood. 120: 325-325. DOI: 10.1182/Blood.V120.21.325.325  0.342
2012 Koduru S, Wong E, Strowig T, Sundaram R, Zhang L, Strout MP, Flavell RA, Schatz DG, Dhodapkar KM, Dhodapkar MV. Abstract 309: Induction of activation-induced cytidine deaminase (AID) by dendritic cells leads to genomic instability in human myeloma Cancer Research. 72: 309-309. DOI: 10.1158/1538-7445.Am2012-309  0.303
2012 Wright S, DeBoer E, Rosenthal A, Flavell RA, Grosveld F. Notice of redundant publicationDNA sequences required for regulated expression of β-globin genes in murine erythroleukaemia cells Philosophical Transactions of the Royal Society B: Biological Sciences. 367: 3059-3059. DOI: 10.1098/Rstb.2012.0385  0.58
2012 Flavell RA, Dong C, Davis RJ. Erratum to: Signaling and cell death in lymphocytes Inflammation Research. 61: 1167-1167. DOI: 10.1007/S00011-012-0525-8  0.31
2011 Tao J, Kamanaka M, Hao J, Hao Z, Jiang X, Craft JE, Flavell RA, Wu Z, Hong Z, Zhao L, Yin Z. IL-10 signaling in CD4+ T cells is critical for the pathogenesis of collagen-induced arthritis. Arthritis Research & Therapy. 13: R212. PMID 22192790 DOI: 10.1186/Ar3545  0.378
2011 Malik AF, Hoque R, Ouyang X, Ghani A, Hong E, Khan K, Moore LB, Ng G, Munro F, Flavell RA, Shi Y, Kyriakides TR, Mehal WZ. Inflammasome components Asc and caspase-1 mediate biomaterial-induced inflammation and foreign body response. Proceedings of the National Academy of Sciences of the United States of America. 108: 20095-100. PMID 22109549 DOI: 10.1073/Pnas.1105152108  0.306
2011 Zou Q, Yao X, Feng J, Yin Z, Flavell R, Hu Y, Zheng G, Jin J, Kang Y, Wu B, Liang X, Feng C, Liu H, Li W, Wang X, et al. Praziquantel facilitates IFN-γ-producing CD8+ T cells (Tc1) and IL-17-producing CD8+ T cells (Tc17) responses to DNA vaccination in mice. Plos One. 6: e25525. PMID 21998665 DOI: 10.1371/Journal.Pone.0025525  0.352
2011 Zhao N, Hao J, Ni Y, Luo W, Liang R, Cao G, Zhao Y, Wang P, Zhao L, Tian Z, Flavell R, Hong Z, Han J, Yao Z, Wu Z, et al. Vγ4 γδ T Cell-Derived IL-17A Negatively Regulates NKT Cell Function in Con A-Induced Fulminant Hepatitis Journal of Immunology. 187: 5007-5014. PMID 21987663 DOI: 10.4049/Jimmunol.1101315  0.398
2011 Allen SJ, Mott KR, Wechsler SL, Flavell RA, Town T, Ghiasi H. Adaptive and innate transforming growth factor beta signaling impact herpes simplex virus 1 latency and reactivation. Journal of Virology. 85: 11448-56. PMID 21880769 DOI: 10.1128/Jvi.00678-11  0.604
2011 Jin C, Frayssinet P, Pelker R, Cwirka D, Hu B, Vignery A, Eisenbarth SC, Flavell RA. NLRP3 inflammasome plays a critical role in the pathogenesis of hydroxyapatite-associated arthropathy. Proceedings of the National Academy of Sciences of the United States of America. 108: 14867-72. PMID 21856950 DOI: 10.1016/J.Joca.2012.02.557  0.33
2011 Balamayooran T, Batra S, Balamayooran G, Cai S, Kobayashi KS, Flavell RA, Jeyaseelan S. Receptor-interacting protein 2 controls pulmonary host defense to Escherichia coli infection via the regulation of interleukin-17A. Infection and Immunity. 79: 4588-99. PMID 21844230 DOI: 10.1128/Iai.05641-11  0.36
2011 Rathinam C, Poueymirou WT, Rojas J, Murphy AJ, Valenzuela DM, Yancopoulos GD, Rongvaux A, Eynon EE, Manz MG, Flavell RA. Efficient differentiation and function of human macrophages in humanized CSF-1 mice. Blood. 118: 3119-28. PMID 21791433 DOI: 10.1182/Blood-2010-12-326926  0.302
2011 Esplugues E, Huber S, Gagliani N, Hauser AE, Town T, Wan YY, O'Connor W, Rongvaux A, Van Rooijen N, Haberman AM, Iwakura Y, Kuchroo VK, Kolls JK, Bluestone JA, Herold KC, ... Flavell RA, et al. Control of TH17 cells occurs in the small intestine. Nature. 475: 514-8. PMID 21765430 DOI: 10.1038/Nature10228  0.601
2011 Ather JL, Ckless K, Martin R, Foley KL, Suratt BT, Boyson JE, Fitzgerald KA, Flavell RA, Eisenbarth SC, Poynter ME. Serum amyloid A activates the NLRP3 inflammasome and promotes Th17 allergic asthma in mice. Journal of Immunology (Baltimore, Md. : 1950). 187: 64-73. PMID 21622869 DOI: 10.4049/Jimmunol.1100500  0.359
2011 Elinav E, Strowig T, Kau AL, Henao-Mejia J, Thaiss CA, Booth CJ, Peaper DR, Bertin J, Eisenbarth SC, Gordon JI, Flavell RA. NLRP6 inflammasome regulates colonic microbial ecology and risk for colitis. Cell. 145: 745-57. PMID 21565393 DOI: 10.1016/J.Cell.2011.04.022  0.363
2011 Hu B, Elinav E, Flavell RA. Inflammasome-mediated suppression of inflammation-induced colorectal cancer progression is mediated by direct regulation of epithelial cell proliferation. Cell Cycle (Georgetown, Tex.). 10: 1936-9. PMID 21555913 DOI: 10.4161/Cc.10.12.16008  0.33
2011 Kamanaka M, Huber S, Zenewicz LA, Gagliani N, Rathinam C, O'Connor W, Wan YY, Nakae S, Iwakura Y, Hao L, Flavell RA. Memory/effector (CD45RB(lo)) CD4 T cells are controlled directly by IL-10 and cause IL-22-dependent intestinal pathology. The Journal of Experimental Medicine. 208: 1027-40. PMID 21518800 DOI: 10.1084/Jem.20102149  0.401
2011 Huber S, Gagliani N, Esplugues E, O'Connor W, Huber FJ, Chaudhry A, Kamanaka M, Kobayashi Y, Booth CJ, Rudensky AY, Roncarolo MG, Battaglia M, Flavell RA. Th17 cells express interleukin-10 receptor and are controlled by Foxp3⁻ and Foxp3+ regulatory CD4+ T cells in an interleukin-10-dependent manner. Immunity. 34: 554-65. PMID 21511184 DOI: 10.1016/J.Immuni.2011.01.020  0.386
2011 Rathinam C, Matesic LE, Flavell RA. The E3 ligase Itch is a negative regulator of the homeostasis and function of hematopoietic stem cells. Nature Immunology. 12: 399-407. PMID 21478879 DOI: 10.1038/Ni.2021  0.307
2011 Wen L, Green EA, Stratmann T, Panosa A, Gomis R, Eynon EE, Flavell RA, Mezquita JA, Mora C. In vivo diabetogenic action of CD4+ T lymphocytes requires Fas expression and is independent of IL-1 and IL-18. European Journal of Immunology. 41: 1344-51. PMID 21469125 DOI: 10.1002/Eji.201041216  0.371
2011 Weisser SB, McLarren KW, Voglmaier N, van Netten-Thomas CJ, Antov A, Flavell RA, Sly LM. Alternative activation of macrophages by IL-4 requires SHIP degradation. European Journal of Immunology. 41: 1742-53. PMID 21469115 DOI: 10.1002/Eji.201041105  0.723
2011 Carter NA, Vasconcellos R, Rosser EC, Tulone C, Muñoz-Suano A, Kamanaka M, Ehrenstein MR, Flavell RA, Mauri C. Mice lacking endogenous IL-10-producing regulatory B cells develop exacerbated disease and present with an increased frequency of Th1/Th17 but a decrease in regulatory T cells Journal of Immunology. 186: 5569-5579. PMID 21464089 DOI: 10.4049/Jimmunol.1100284  0.394
2011 Hoque R, Sohail M, Malik A, Sarwar S, Luo Y, Shah A, Barrat F, Flavell R, Gorelick F, Husain S, Mehal W. TLR9 and the NLRP3 Inflammasome Link Acinar Cell Death With Inflammation in Acute Pancreatitis Gastroenterology. 141: 358-369. PMID 21439959 DOI: 10.1053/J.Gastro.2011.03.041  0.325
2011 Gutcher I, Donkor MK, Ma Q, Rudensky AY, Flavell RA, Li MO. Autocrine transforming growth factor-β1 promotes in vivo Th17 cell differentiation. Immunity. 34: 396-408. PMID 21435587 DOI: 10.1016/J.Immuni.2011.03.005  0.365
2011 Nel HJ, Hams E, Saunders SP, Mangan NE, Smith P, Atzberger A, Flavell RA, Akira S, McKenzie AN, Fallon PG. Impaired basophil induction leads to an age-dependent innate defect in type 2 immunity during helminth infection in mice. Journal of Immunology (Baltimore, Md. : 1950). 186: 4631-9. PMID 21398616 DOI: 10.4049/Jimmunol.1002995  0.367
2011 Kreuzaler PA, Staniszewska AD, Li W, Omidvar N, Kedjouar B, Turkson J, Poli V, Flavell RA, Clarkson RW, Watson CJ. Stat3 controls lysosomal-mediated cell death in vivo. Nature Cell Biology. 13: 303-9. PMID 21336304 DOI: 10.1038/Ncb2171  0.335
2011 Zhang G, Chen M, Graham D, Subsin B, McDougall C, Gilady S, Kneteman M, Law L, Swain M, Trauner M, Wrzesinski S, Flavell R, Wasilenko S, Mason A. Mouse mammary tumor virus in anti-mitochondrial antibody producing mouse models. Journal of Hepatology. 55: 876-84. PMID 21334408 DOI: 10.1016/J.Jhep.2011.01.037  0.331
2011 Rongvaux A, Willinger T, Takizawa H, Rathinam C, Auerbach W, Murphy AJ, Valenzuela DM, Yancopoulos GD, Eynon EE, Stevens S, Manz MG, Flavell RA. Human thrombopoietin knockin mice efficiently support human hematopoiesis in vivo. Proceedings of the National Academy of Sciences of the United States of America. 108: 2378-83. PMID 21262827 DOI: 10.1182/Blood.V116.21.403.403  0.301
2011 Willinger T, Rongvaux A, Takizawa H, Yancopoulos GD, Valenzuela DM, Murphy AJ, Auerbach W, Eynon EE, Stevens S, Manz MG, Flavell RA. Human IL-3/GM-CSF knock-in mice support human alveolar macrophage development and human immune responses in the lung. Proceedings of the National Academy of Sciences of the United States of America. 108: 2390-5. PMID 21262803 DOI: 10.1073/Pnas.1019682108  0.337
2011 Mott KR, Gate D, Zandian M, Allen SJ, Rajasagi NK, van Rooijen N, Chen S, Arditi M, Rouse BT, Flavell RA, Town T, Ghiasi H. Macrophage IL-12p70 signaling prevents HSV-1-induced CNS autoimmunity triggered by autoaggressive CD4+ Tregs. Investigative Ophthalmology & Visual Science. 52: 2321-33. PMID 21220560 DOI: 10.1167/Iovs.10-6536  0.775
2011 Cole JE, Navin TJ, Cross AJ, Goddard ME, Alexopoulou L, Mitra AT, Davies AH, Flavell RA, Feldmann M, Monaco C. Unexpected protective role for Toll-like receptor 3 in the arterial wall. Proceedings of the National Academy of Sciences of the United States of America. 108: 2372-7. PMID 21220319 DOI: 10.1073/Pnas.1018515108  0.327
2011 Sayi A, Kohler E, Toller IM, Flavell RA, Müller W, Roers A, Müller A. TLR-2-activated B cells suppress Helicobacter-induced preneoplastic gastric immunopathology by inducing T regulatory-1 cells. Journal of Immunology (Baltimore, Md. : 1950). 186: 878-90. PMID 21149607 DOI: 10.4049/Jimmunol.1002269  0.39
2011 Bunting RA, Duffy KE, Lamb RJ, San Mateo LR, Smalley K, Raymond H, Liu X, Petley T, Fisher J, Beck H, Flavell RA, Alexopoulou L, Ward CK. Novel antagonist antibody to TLR3 blocks poly(I:C)-induced inflammation in vivo and in vitro. Cellular Immunology. 267: 9-16. PMID 21092943 DOI: 10.1016/J.Cellimm.2010.10.008  0.337
2011 Cole JE, Navin TJ, Cross AJ, Goddard ME, Alexopoulou L, Mitra AJ, Davies AH, Flavell RA, Feldmann M, Monaco C. YIA 1 Toll-like receptor 3 expression is increased in atherosclerosis and confers protection against early atherosclerotic lesion development and weight gain in apolipoprotein E deficient mice Heart. 97: e7-e7. DOI: 10.1136/Heartjnl-2011-300920A.1  0.326
2010 Hu B, Elinav E, Huber S, Booth CJ, Strowig T, Jin C, Eisenbarth SC, Flavell RA. Inflammation-induced tumorigenesis in the colon is regulated by caspase-1 and NLRC4. Proceedings of the National Academy of Sciences of the United States of America. 107: 21635-40. PMID 21118981 DOI: 10.1073/Pnas.1016814108  0.34
2010 Song J, Willinger T, Rongvaux A, Eynon EE, Stevens S, Manz MG, Flavell RA, Galán JE. A mouse model for the human pathogen Salmonella typhi. Cell Host & Microbe. 8: 369-76. PMID 20951970 DOI: 10.1016/J.Chom.2010.09.003  0.304
2010 Wang Y, Souabni A, Flavell RA, Wan YY. An intrinsic mechanism predisposes Foxp3-expressing regulatory T cells to Th2 conversion in vivo. Journal of Immunology (Baltimore, Md. : 1950). 185: 5983-92. PMID 20944002 DOI: 10.4049/Jimmunol.1001255  0.403
2010 Chi H, Flavell RA. Studies on MAP Kinase signaling in the immune system. Methods in Molecular Biology (Clifton, N.J.). 661: 471-80. PMID 20812002 DOI: 10.1007/978-1-60761-795-2_29  0.375
2010 Demaria O, Pagni PP, Traub S, de Gassart A, Branzk N, Murphy AJ, Valenzuela DM, Yancopoulos GD, Flavell RA, Alexopoulou L. TLR8 deficiency leads to autoimmunity in mice. The Journal of Clinical Investigation. 120: 3651-62. PMID 20811154 DOI: 10.1172/Jci42081  0.322
2010 Hawiger D, Wan YY, Eynon EE, Flavell RA. The transcription cofactor Hopx is required for regulatory T cell function in dendritic cell-mediated peripheral T cell unresponsiveness. Nature Immunology. 11: 962-8. PMID 20802482 DOI: 10.1038/Ni.1929  0.369
2010 Huber S, Flavell RA. Checks and balances: IL-23 in the intestine. Immunity. 33: 150-2. PMID 20732638 DOI: 10.1016/J.Immuni.2010.08.005  0.367
2010 Frutuoso MS, Hori JI, Pereira MSF, Junior DSL, Sônego F, Kobayashi KS, Flavell RA, Cunha FQ, Zamboni DS. The pattern recognition receptors Nod1 and Nod2 account for neutrophil recruitment to the lungs of mice infected with Legionella pneumophila Microbes and Infection. 12: 819-827. PMID 20685341 DOI: 10.1016/J.Micinf.2010.05.006  0.316
2010 Morel C, Standen CL, Jung DY, Gray S, Ong H, Flavell RA, Kim JK, Davis RJ. Requirement of JIP1-mediated c-Jun N-terminal kinase activation for obesity-induced insulin resistance. Molecular and Cellular Biology. 30: 4616-25. PMID 20679483 DOI: 10.1128/Mcb.00585-10  0.319
2010 Zhang W, Tsuda M, Yang GX, Tsuneyama K, Rong G, Ridgway WM, Ansari AA, Flavell RA, Coppel RL, Lian ZX, Gershwin ME. Deletion of interleukin-6 in mice with the dominant negative form of transforming growth factor beta receptor II improves colitis but exacerbates autoimmune cholangitis. Hepatology (Baltimore, Md.). 52: 215-22. PMID 20578264 DOI: 10.1002/Hep.23664  0.354
2010 He W, Hao J, Dong S, Gao Y, Tao J, Chi H, Flavell R, O'Brien RL, Born WK, Craft J, Han J, Wang P, Zhao L, Wu J, Yin Z. Naturally activated V gamma 4 gamma delta T cells play a protective role in tumor immunity through expression of eomesodermin. Journal of Immunology (Baltimore, Md. : 1950). 185: 126-33. PMID 20525896 DOI: 10.4049/Jimmunol.0903767  0.378
2010 O'Connor W, Zenewicz LA, Flavell RA. The dual nature of T(H)17 cells: shifting the focus to function. Nature Immunology. 11: 471-6. PMID 20485275 DOI: 10.1038/Ni.1882  0.353
2010 Koh BH, Hwang SS, Kim JY, Lee W, Kang MJ, Lee CG, Park JW, Flavell RA, Lee GR. Th2 LCR is essential for regulation of Th2 cytokine genes and for pathogenesis of allergic asthma. Proceedings of the National Academy of Sciences of the United States of America. 107: 10614-9. PMID 20483988 DOI: 10.1073/Pnas.1005383107  0.358
2010 Li MO, Flavell RA. TGF-beta, T-cell tolerance and immunotherapy of autoimmune diseases and cancer. Expert Review of Clinical Immunology. 2: 257-65. PMID 20477076 DOI: 10.1586/1744666X.2.2.257  0.348
2010 Hubbard LL, Ballinger MN, Thomas PE, Wilke CA, Standiford TJ, Kobayashi KS, Flavell RA, Moore BB. A role for IL-1 receptor-associated kinase-M in prostaglandin E2-induced immunosuppression post-bone marrow transplantation. Journal of Immunology (Baltimore, Md. : 1950). 184: 6299-308. PMID 20439918 DOI: 10.4049/Jimmunol.0902828  0.316
2010 Yamamoto Y, Moore R, Flavell RA, Lu B, Negishi M. Nuclear receptor CAR represses TNFalpha-induced cell death by interacting with the anti-apoptotic GADD45B. Plos One. 5: e10121. PMID 20404936 DOI: 10.1371/Journal.Pone.0010121  0.31
2010 Ktistaki E, Garefalaki A, Williams A, Andrews SR, Bell DM, Foster KE, Spilianakis CG, Flavell RA, Kosyakova N, Trifonov V, Liehr T, Kioussis D. CD8 locus nuclear dynamics during thymocyte development. Journal of Immunology (Baltimore, Md. : 1950). 184: 5686-95. PMID 20404270 DOI: 10.4049/Jimmunol.1000170  0.312
2010 Shi Y, Liu XF, Zhuang Y, Zhang JY, Liu T, Yin Z, Wu C, Mao XH, Jia KR, Wang FJ, Guo H, Flavell RA, Zhao Z, Liu KY, Xiao B, et al. Helicobacter pylori-induced Th17 responses modulate Th1 cell responses, benefit bacterial growth, and contribute to pathology in mice. Journal of Immunology (Baltimore, Md. : 1950). 184: 5121-9. PMID 20351183 DOI: 10.4049/Jimmunol.0901115  0.344
2010 Archer KA, Ader F, Kobayashi KS, Flavell RA, Roy CR. Cooperation between multiple microbial pattern recognition systems is important for host protection against the intracellular pathogen Legionella pneumophila. Infection and Immunity. 78: 2477-87. PMID 20351139 DOI: 10.1128/Iai.00243-10  0.333
2010 Ruschmann J, Ho V, Antignano F, Kuroda E, Lam V, Ibaraki M, Snyder K, Kim C, Flavell RA, Kawakami T, Sly L, Turhan AG, Krystal G. Tyrosine phosphorylation of SHIP promotes its proteasomal degradation. Experimental Hematology. 38: 392-402, 402.e1. PMID 20304029 DOI: 10.1016/J.Exphem.2010.03.010  0.318
2010 Mayer-Barber KD, Barber DL, Shenderov K, White SD, Wilson MS, Cheever A, Kugler D, Hieny S, Caspar P, Núñez G, Schlueter D, Flavell RA, Sutterwala FS, Sher A. Caspase-1 independent IL-1beta production is critical for host resistance to mycobacterium tuberculosis and does not require TLR signaling in vivo. Journal of Immunology (Baltimore, Md. : 1950). 184: 3326-30. PMID 20200276 DOI: 10.4049/Jimmunol.0904189  0.347
2010 Kinnebrew MA, Ubeda C, Zenewicz LA, Smith N, Flavell RA, Pamer EG. Bacterial flagellin stimulates Toll-like receptor 5-dependent defense against vancomycin-resistant Enterococcus infection. The Journal of Infectious Diseases. 201: 534-43. PMID 20064069 DOI: 10.1086/650203  0.331
2010 Silva GK, Gutierrez FRS, Guedes PMM, Horta CV, Cunha LD, Mineo TWP, Santiago-Silva J, Kobayashi KS, Flavell RA, Silva JS, Zamboni DS. Cutting edge: Nucleotide-binding oligomerization domain 1-dependent responses account for murine resistance against Trypanosoma cruzi infection Journal of Immunology. 184: 1148-1152. PMID 20042586 DOI: 10.4049/Jimmunol.0902254  0.334
2010 Hübner A, Cavanagh-Kyros J, Rincon M, Flavell RA, Davis RJ. Functional cooperation of the proapoptotic Bcl2 family proteins Bmf and Bim in vivo. Molecular and Cellular Biology. 30: 98-105. PMID 19841067 DOI: 10.1128/Mcb.01155-09  0.311
2009 Iyer SS, Pulskens WP, Sadler JJ, Butter LM, Teske GJ, Ulland TK, Eisenbarth SC, Florquin S, Flavell RA, Leemans JC, Sutterwala FS. Necrotic cells trigger a sterile inflammatory response through the Nlrp3 inflammasome. Proceedings of the National Academy of Sciences of the United States of America. 106: 20388-93. PMID 19918053 DOI: 10.1073/Pnas.0908698106  0.354
2009 Jha MK, Badou A, Meissner M, McRory JE, Freichel M, Flockerzi V, Flavell RA. Defective survival of naive CD8+ T lymphocytes in the absence of the beta3 regulatory subunit of voltage-gated calcium channels. Nature Immunology. 10: 1275-82. PMID 19838200 DOI: 10.1038/Ni.1793  0.307
2009 Bai F, Town T, Qian F, Wang P, Kamanaka M, Connolly TM, Gate D, Montgomery RR, Flavell RA, Fikrig E. IL-10 signaling blockade controls murine West Nile virus infection. Plos Pathogens. 5: e1000610. PMID 19816558 DOI: 10.1371/Journal.Ppat.1000610  0.757
2009 Fikrig E, Narasimhan S, Neelakanta G, Pal U, Chen M, Flavell R. Toll-like receptors 1 and 2 heterodimers alter Borrelia burgdorferi gene expression in mice and ticks. The Journal of Infectious Diseases. 200: 1331-40. PMID 19754309 DOI: 10.1086/605950  0.329
2009 Bogani D, Siggers P, Brixey R, Warr N, Beddow S, Edwards J, Williams D, Wilhelm D, Koopman P, Flavell RA, Chi H, Ostrer H, Wells S, Cheeseman M, Greenfield A. Loss of mitogen-activated protein kinase kinase kinase 4 (MAP3K4) reveals a requirement for MAPK signalling in mouse sex determination. Plos Biology. 7: e1000196. PMID 19753101 DOI: 10.1371/Journal.Pbio.1000196  0.331
2009 Bhowmick S, Singh A, Flavell RA, Clark RB, O'Rourke J, Cone RE. The sympathetic nervous system modulates CD4(+)FoxP3(+) regulatory T cells via a TGF-beta-dependent mechanism. Journal of Leukocyte Biology. 86: 1275-83. PMID 19741161 DOI: 10.1189/Jlb.0209107  0.357
2009 Marks BR, Nowyhed HN, Choi JY, Poholek AC, Odegard JM, Flavell RA, Craft J. Thymic self-reactivity selects natural interleukin 17-producing T cells that can regulate peripheral inflammation. Nature Immunology. 10: 1125-32. PMID 19734905 DOI: 10.1038/Ni.1783  0.381
2009 Kuroda E, Ho V, Ruschmann J, Antignano F, Hamilton M, Rauh MJ, Antov A, Flavell RA, Sly LM, Krystal G. SHIP represses the generation of IL-3-induced M2 macrophages by inhibiting IL-4 production from basophils. Journal of Immunology (Baltimore, Md. : 1950). 183: 3652-60. PMID 19710468 DOI: 10.4049/Jimmunol.0900864  0.724
2009 Xiao X, Zhao P, Rodriguez-Pinto D, Qi D, Henegariu O, Alexopoulou L, Flavell RA, Wong FS, Wen L. Inflammatory regulation by TLR3 in acute hepatitis. Journal of Immunology (Baltimore, Md. : 1950). 183: 3712-9. PMID 19710451 DOI: 10.4049/Jimmunol.0901221  0.349
2009 Shio MT, Eisenbarth SC, Savaria M, Vinet AF, Bellemare MJ, Harder KW, Sutterwala FS, Bohle DS, Descoteaux A, Flavell RA, Olivier M. Malarial hemozoin activates the NLRP3 inflammasome through Lyn and Syk kinases. Plos Pathogens. 5: e1000559. PMID 19696895 DOI: 10.1371/Journal.Ppat.1000559  0.362
2009 Bruno VM, Hannemann S, Lara-Tejero M, Flavell RA, Kleinstein SH, Galán JE. Salmonella Typhimurium type III secretion effectors stimulate innate immune responses in cultured epithelial cells. Plos Pathogens. 5: e1000538. PMID 19662166 DOI: 10.1371/Journal.Ppat.1000538  0.333
2009 Shilling RA, Clay BS, Tesciuba AG, Berry EL, Lu T, Moore TV, Bandukwala HS, Tong J, Weinstock JV, Flavell RA, Horan T, Yoshinaga SK, Welcher AA, Cannon JL, Sperling AI. CD28 and ICOS play complementary non-overlapping roles in the development of Th2 immunity in vivo. Cellular Immunology. 259: 177-84. PMID 19646680 DOI: 10.1016/J.Cellimm.2009.06.013  0.343
2009 Paolo NCD, Miao EA, Iwakura Y, Murali-Krishna K, Aderem A, Flavell RA, Papayannopoulou T, Shayakhmetov DM. Virus Binding to a Plasma Membrane Receptor Triggers Interleukin-1α-Mediated Proinflammatory Macrophage Response In Vivo Immunity. 31: 110-121. PMID 19576795 DOI: 10.1016/J.Immuni.2009.04.015  0.353
2009 Kamanaka M, Rainbow D, Schuster-Gossler K, Eynon EE, Chervonsky AV, Wicker LS, Flavell RA. Amino acid polymorphisms altering the glycosylation of IL-2 do not protect from type 1 diabetes in the NOD mouse. Proceedings of the National Academy of Sciences of the United States of America. 106: 11236-40. PMID 19549859 DOI: 10.1073/Pnas.0904780106  0.343
2009 Ince MN, Elliott DE, Setiawan T, Metwali A, Blum A, Chen HL, Urban JF, Flavell RA, Weinstock JV. Role of T cell TGF-beta signaling in intestinal cytokine responses and helminthic immune modulation. European Journal of Immunology. 39: 1870-8. PMID 19544487 DOI: 10.1002/Eji.200838956  0.381
2009 Tirapu I, Giquel B, Alexopoulou L, Uematsu S, Flavell R, Akira S, Diebold SS. PolyI:C-induced reduction in uptake of soluble antigen is independent of dendritic cell activation. International Immunology. 21: 871-9. PMID 19505890 DOI: 10.1093/Intimm/Dxp053  0.32
2009 Matza D, Badou A, Jha MK, Willinger T, Antov A, Sanjabi S, Kobayashi KS, Marchesi VT, Flavell RA. Requirement for AHNAK1-mediated calcium signaling during T lymphocyte cytolysis. Proceedings of the National Academy of Sciences of the United States of America. 106: 9785-90. PMID 19497879 DOI: 10.1073/Pnas.0902844106  0.723
2009 Stowell NC, Seideman J, Raymond HA, Smalley KA, Lamb RJ, Egenolf DD, Bugelski PJ, Murray LA, Marsters PA, Bunting RA, Flavell RA, Alexopoulou L, San Mateo LR, Griswold DE, Sarisky RT, et al. Long-term activation of TLR3 by poly(I:C) induces inflammation and impairs lung function in mice. Respiratory Research. 10: 43. PMID 19486528 DOI: 10.1186/1465-9921-10-43  0.322
2009 Liu G, Burns S, Huang G, Boyd K, Proia RL, Flavell RA, Chi H. The receptor S1P1 overrides regulatory T cell-mediated immune suppression through Akt-mTOR. Nature Immunology. 10: 769-77. PMID 19483717 DOI: 10.1038/Ni.1743  0.368
2009 Wan YY, Flavell RA. How diverse--CD4 effector T cells and their functions. Journal of Molecular Cell Biology. 1: 20-36. PMID 19482777 DOI: 10.1093/Jmcb/Mjp001  0.378
2009 O'Connor W, Kamanaka M, Booth CJ, Town T, Nakae S, Iwakura Y, Kolls JK, Flavell RA. A protective function for interleukin 17A in T cell-mediated intestinal inflammation. Nature Immunology. 10: 603-9. PMID 19448631 DOI: 10.1038/Ni.1736  0.611
2009 Demento SL, Eisenbarth SC, Foellmer HG, Platt C, Caplan MJ, Mark Saltzman W, Mellman I, Ledizet M, Fikrig E, Flavell RA, Fahmy TM. Inflammasome-activating nanoparticles as modular systems for optimizing vaccine efficacy. Vaccine. 27: 3013-21. PMID 19428913 DOI: 10.1016/J.Vaccine.2009.03.034  0.339
2009 Lee CG, Hartl D, Lee GR, Koller B, Matsuura H, Da Silva CA, Sohn MH, Cohn L, Homer RJ, Kozhich AA, Humbles A, Kearley J, Coyle A, Chupp G, Reed J, ... Flavell RA, et al. Role of breast regression protein 39 (BRP-39)/chitinase 3-like-1 in Th2 and IL-13-induced tissue responses and apoptosis. The Journal of Experimental Medicine. 206: 1149-66. PMID 19414556 DOI: 10.1084/Jem.20081271  0.384
2009 Galluzzi L, Aaronson SA, Abrams J, Alnemri ES, Andrews DW, Baehrecke EH, Bazan NG, Blagosklonny MV, Blomgren K, Borner C, Bredesen DE, Brenner C, Castedo M, Cidlowski JA, Ciechanover A, ... ... Flavell RA, et al. Guidelines for the use and interpretation of assays for monitoring cell death in higher eukaryotes. Cell Death and Differentiation. 16: 1093-107. PMID 19373242 DOI: 10.1038/Cdd.2009.44  0.313
2009 Zenewicz LA, Antov A, Flavell RA. CD4 T-cell differentiation and inflammatory bowel disease. Trends in Molecular Medicine. 15: 199-207. PMID 19362058 DOI: 10.1016/J.Molmed.2009.03.002  0.73
2009 Watanabe A, Sohail MA, Gomes DA, Hashmi A, Nagata J, Sutterwala FS, Mahmood S, Jhandier MN, Shi Y, Flavell RA, Mehal WZ. Inflammasome-mediated regulation of hepatic stellate cells. American Journal of Physiology. Gastrointestinal and Liver Physiology. 296: G1248-57. PMID 19359429 DOI: 10.1152/Ajpgi.90223.2008  0.357
2009 Hartl D, He CH, Koller B, Da Silva CA, Kobayashi Y, Lee CG, Flavell RA, Elias JA. Acidic mammalian chitinase regulates epithelial cell apoptosis via a chitinolytic-independent mechanism. Journal of Immunology (Baltimore, Md. : 1950). 182: 5098-106. PMID 19342690 DOI: 10.4049/Jimmunol.0803446  0.34
2009 Huber S, Stahl FR, Schrader J, Lüth S, Presser K, Carambia A, Flavell RA, Werner S, Blessing M, Herkel J, Schramm C. Activin a promotes the TGF-beta-induced conversion of CD4+CD25- T cells into Foxp3+ induced regulatory T cells. Journal of Immunology (Baltimore, Md. : 1950). 182: 4633-40. PMID 19342638 DOI: 10.4049/Jimmunol.0803143  0.347
2009 Cone RE, Chattopadhyay S, Sharafieh R, Lemire Y, O'Rourke J, Flavell RA, Clark RB. T cell sensitivity to TGF-beta is required for the effector function but not the generation of splenic CD8+ regulatory T cells induced via the injection of antigen into the anterior chamber. International Immunology. 21: 567-74. PMID 19325036 DOI: 10.1093/Intimm/Dxp023  0.37
2009 Odegard JM, DiPlacido LD, Greenwald L, Kashgarian M, Kono DH, Dong C, Flavell RA, Craft J. ICOS controls effector function but not trafficking receptor expression of kidney-infiltrating effector T cells in murine lupus. Journal of Immunology (Baltimore, Md. : 1950). 182: 4076-84. PMID 19299705 DOI: 10.4049/Jimmunol.0800758  0.368
2009 Ouyang W, Beckett O, Flavell RA, Li MO. An essential role of the Forkhead-box transcription factor Foxo1 in control of T cell homeostasis and tolerance. Immunity. 30: 358-71. PMID 19285438 DOI: 10.1016/J.Immuni.2009.02.003  0.387
2009 Mikkelsen SS, Jensen SB, Chiliveru S, Melchjorsen J, Julkunen I, Gaestel M, Arthur JS, Flavell RA, Ghosh S, Paludan SR. RIG-I-mediated activation of p38 MAPK is essential for viral induction of interferon and activation of dendritic cells: dependence on TRAF2 and TAK1. The Journal of Biological Chemistry. 284: 10774-82. PMID 19224920 DOI: 10.1074/Jbc.M807272200  0.329
2009 Town T, Bai F, Wang T, Kaplan AT, Qian F, Montgomery RR, Anderson JF, Flavell RA, Fikrig E. Toll-like receptor 7 mitigates lethal West Nile encephalitis via interleukin 23-dependent immune cell infiltration and homing. Immunity. 30: 242-53. PMID 19200759 DOI: 10.1016/J.Immuni.2008.11.012  0.618
2009 Das M, Sabio G, Jiang F, Rincón M, Flavell RA, Davis RJ. Induction of hepatitis by JNK-mediated expression of TNF-alpha. Cell. 136: 249-60. PMID 19167327 DOI: 10.1016/J.Cell.2008.11.017  0.317
2009 Amsen D, Antov A, Flavell RA. The different faces of Notch in T-helper-cell differentiation. Nature Reviews. Immunology. 9: 116-24. PMID 19165228 DOI: 10.1038/Nri2488  0.738
2009 Imaeda AB, Watanabe A, Sohail MA, Mahmood S, Mohamadnejad M, Sutterwala FS, Flavell RA, Mehal WZ. Acetaminophen-induced hepatotoxicity in mice is dependent on Tlr9 and the Nalp3 inflammasome. The Journal of Clinical Investigation. 119: 305-14. PMID 19164858 DOI: 10.1172/Jci35958  0.355
2009 Ichinohe T, Lee HK, Ogura Y, Flavell R, Iwasaki A. Inflammasome recognition of influenza virus is essential for adaptive immune responses. The Journal of Experimental Medicine. 206: 79-87. PMID 19139171 DOI: 10.1084/Jem.20081667  0.35
2009 Rosenzweig HL, Jann MM, Glant TT, Martin TM, Planck SR, van Eden W, van Kooten PJ, Flavell RA, Kobayashi KS, Rosenbaum JT, Davey MP. Activation of nucleotide oligomerization domain 2 exacerbates a murine model of proteoglycan-induced arthritis. Journal of Leukocyte Biology. 85: 711-8. PMID 19129483 DOI: 10.1189/Jlb.0808478  0.349
2009 Wong FS, Hu C, Zhang L, Du W, Alexopoulou L, Flavell RA, Wen L. The role of Toll-like receptors 3 and 9 in the development of autoimmune diabetes in NOD mice. Annals of the New York Academy of Sciences. 1150: 146-8. PMID 19120284 DOI: 10.1196/Annals.1447.039  0.319
2009 Moritoki Y, Zhang W, Tsuneyama K, Yoshida K, Wakabayashi K, Yang GX, Bowlus C, Ridgway WM, Ueno Y, Ansari AA, Coppel RL, Mackay IR, Flavell RA, Gershwin ME, Lian ZX. B cells suppress the inflammatory response in a mouse model of primary biliary cirrhosis. Gastroenterology. 136: 1037-47. PMID 19118554 DOI: 10.1053/J.Gastro.2008.11.035  0.345
2009 Brochard V, Combadière B, Prigent A, Laouar Y, Perrin A, Beray-Berthat V, Bonduelle O, Alvarez-Fischer D, Callebert J, Launay JM, Duyckaerts C, Flavell RA, Hirsch EC, Hunot S. Infiltration of CD4+ lymphocytes into the brain contributes to neurodegeneration in a mouse model of Parkinson disease. The Journal of Clinical Investigation. 119: 182-92. PMID 19104149 DOI: 10.1172/Jci36470  0.356
2009 Diebold SS, Schulz O, Alexopoulou L, Leitner WW, Flavell RA, Reis e Sousa C. Role of TLR3 in the immunogenicity of replicon plasmid-based vaccines. Gene Therapy. 16: 359-66. PMID 19052633 DOI: 10.1038/Gt.2008.164  0.327
2009 Rabinovich PM, Komarovskaya ME, Wrzesinski SH, Alderman JL, Budak-Alpdogan T, Karpikov A, Guo H, Flavell RA, Cheung NK, Weissman SM, Bahceci E. Chimeric receptor mRNA transfection as a tool to generate antineoplastic lymphocytes. Human Gene Therapy. 20: 51-61. PMID 19025415 DOI: 10.1089/Hum.2008.068  0.32
2009 Archer KA, Alexopoulou L, Flavell RA, Roy CR. Multiple MyD88-dependent responses contribute to pulmonary clearance of Legionella pneumophila. Cellular Microbiology. 11: 21-36. PMID 18782351 DOI: 10.1111/J.1462-5822.2008.01234.X  0.365
2008 Zenewicz LA, Yancopoulos GD, Valenzuela DM, Murphy AJ, Stevens S, Flavell RA. Innate and adaptive interleukin-22 protects mice from inflammatory bowel disease. Immunity. 29: 947-57. PMID 19100701 DOI: 10.1016/J.Immuni.2008.11.003  0.399
2008 Shin S, Case CL, Archer KA, Nogueira CV, Kobayashi KS, Flavell RA, Roy CR, Zamboni DS. Type IV secretion-dependent activation of host MAP kinases induces an increased proinflammatory cytokine response to Legionella pneumophila. Plos Pathogens. 4: e1000220. PMID 19043549 DOI: 10.1371/Journal.Ppat.1000220  0.319
2008 Ries V, Silva RM, Oo TF, Cheng HC, Rzhetskaya M, Kholodilov N, Flavell RA, Kuan CY, Rakic P, Burke RE. JNK2 and JNK3 combined are essential for apoptosis in dopamine neurons of the substantia nigra, but are not required for axon degeneration. Journal of Neurochemistry. 107: 1578-88. PMID 19014392 DOI: 10.1111/J.1471-4159.2008.05713.X  0.485
2008 Odegard JM, Marks BR, DiPlacido LD, Poholek AC, Kono DH, Dong C, Flavell RA, Craft J. ICOS-dependent extrafollicular helper T cells elicit IgG production via IL-21 in systemic autoimmunity. The Journal of Experimental Medicine. 205: 2873-86. PMID 18981236 DOI: 10.1084/Jem.20080840  0.409
2008 Divangahi M, Mostowy S, Coulombe F, Kozak R, Guillot L, Veyrier F, Kobayashi KS, Flavell RA, Gros P, Behr MA. NOD2-deficient mice have impaired resistance to Mycobacterium tuberculosis infection through defective innate and adaptive immunity. Journal of Immunology (Baltimore, Md. : 1950). 181: 7157-65. PMID 18981137 DOI: 10.4049/Jimmunol.181.10.7157  0.358
2008 Stephens TA, Nikoopour E, Rider BJ, Leon-Ponte M, Chau TA, Mikolajczak S, Chaturvedi P, Lee-Chan E, Flavell RA, Haeryfar SM, Madrenas J, Singh B. Dendritic cell differentiation induced by a self-peptide derived from apolipoprotein E. Journal of Immunology (Baltimore, Md. : 1950). 181: 6859-71. PMID 18981105 DOI: 10.4049/Jimmunol.181.10.6859  0.373
2008 Watanabe C, Shu GL, Zheng TS, Flavell RA, Clark EA. Caspase 6 regulates B cell activation and differentiation into plasma cells. Journal of Immunology (Baltimore, Md. : 1950). 181: 6810-9. PMID 18981099 DOI: 10.4049/Jimmunol.181.10.6810  0.338
2008 Chi H, Flavell RA. Acetylation of MKP-1 and the control of inflammation. Science Signaling. 1: pe44. PMID 18922786 DOI: 10.1126/Scisignal.141Pe44  0.339
2008 Sutterwala FS, Flavell RA. NLRC4/IPAF: a CARD carrying member of the NLR family. Clinical Immunology (Orlando, Fla.). 130: 2-6. PMID 18819842 DOI: 10.1016/J.Clim.2008.08.011  0.335
2008 Wan YY, Flavell RA. TGF-beta and regulatory T cell in immunity and autoimmunity. Journal of Clinical Immunology. 28: 647-59. PMID 18792765 DOI: 10.1007/S10875-008-9251-Y  0.358
2008 Breunig JJ, Sarkisian MR, Arellano JI, Morozov YM, Ayoub AE, Sojitra S, Wang B, Flavell RA, Rakic P, Town T. Primary cilia regulate hippocampal neurogenesis by mediating sonic hedgehog signaling. Proceedings of the National Academy of Sciences of the United States of America. 105: 13127-32. PMID 18728187 DOI: 10.1073/Pnas.0804558105  0.665
2008 Li MO, Flavell RA. TGF-beta: a master of all T cell trades. Cell. 134: 392-404. PMID 18692464 DOI: 10.1016/J.Cell.2008.07.025  0.34
2008 Filippi CM, Juedes AE, Oldham JE, Ling E, Togher L, Peng Y, Flavell RA, von Herrath MG. Transforming growth factor-beta suppresses the activation of CD8+ T-cells when naive but promotes their survival and function once antigen experienced: a two-faced impact on autoimmunity. Diabetes. 57: 2684-92. PMID 18689691 DOI: 10.2337/Db08-0609  0.344
2008 Laouar Y, Town T, Jeng D, Tran E, Wan Y, Kuchroo VK, Flavell RA. TGF-beta signaling in dendritic cells is a prerequisite for the control of autoimmune encephalomyelitis. Proceedings of the National Academy of Sciences of the United States of America. 105: 10865-70. PMID 18669656 DOI: 10.1073/Pnas.0805058105  0.622
2008 Wang S, Welte T, McGargill M, Town T, Thompson J, Anderson JF, Flavell RA, Fikrig E, Hedrick SM, Wang T. Drak2 contributes to West Nile virus entry into the brain and lethal encephalitis. Journal of Immunology (Baltimore, Md. : 1950). 181: 2084-91. PMID 18641347 DOI: 10.4049/Jimmunol.181.3.2084  0.604
2008 Cassel SL, Eisenbarth SC, Iyer SS, Sadler JJ, Colegio OR, Tephly LA, Carter AB, Rothman PB, Flavell RA, Sutterwala FS. The Nalp3 inflammasome is essential for the development of silicosis. Proceedings of the National Academy of Sciences of the United States of America. 105: 9035-40. PMID 18577586 DOI: 10.1073/Pnas.0803933105  0.333
2008 Czyzyk J, Chen HC, Bottomly K, Flavell RA. p21 Ras/impedes mitogenic signal propagation regulates cytokine production and migration in CD4 T cells. The Journal of Biological Chemistry. 283: 23004-15. PMID 18577512 DOI: 10.1074/Jbc.M804084200  0.377
2008 Fujita J, Crane AM, Souza MK, Dejosez M, Kyba M, Flavell RA, Thomson JA, Zwaka TP. Caspase activity mediates the differentiation of embryonic stem cells. Cell Stem Cell. 2: 595-601. PMID 18522852 DOI: 10.1016/J.Stem.2008.04.001  0.301
2008 Town T, Laouar Y, Pittenger C, Mori T, Szekely CA, Tan J, Duman RS, Flavell RA. Blocking TGF-beta-Smad2/3 innate immune signaling mitigates Alzheimer-like pathology. Nature Medicine. 14: 681-7. PMID 18516051 DOI: 10.1038/Nm1781  0.572
2008 Hübner A, Barrett T, Flavell RA, Davis RJ. Multisite phosphorylation regulates Bim stability and apoptotic activity. Molecular Cell. 30: 415-25. PMID 18498746 DOI: 10.1016/J.Molcel.2008.03.025  0.307
2008 Eisenbarth SC, Colegio OR, O'Connor W, Sutterwala FS, Flavell RA. Crucial role for the Nalp3 inflammasome in the immunostimulatory properties of aluminium adjuvants. Nature. 453: 1122-6. PMID 18496530 DOI: 10.1038/Nature06939  0.356
2008 Rosenzweig HL, Martin TM, Planck SR, Galster K, Jann MM, Davey MP, Kobayashi K, Flavell RA, Rosenbaum JT. Activation of NOD2 in vivo induces IL-1beta production in the eye via caspase-1 but results in ocular inflammation independently of IL-1 signaling. Journal of Leukocyte Biology. 84: 529-36. PMID 18495787 DOI: 10.1189/Jlb.0108015  0.357
2008 Lafon M, Mégret F, Meuth SG, Simon O, Velandia Romero ML, Lafage M, Chen L, Alexopoulou L, Flavell RA, Prehaud C, Wiendl H. Detrimental contribution of the immuno-inhibitor B7-H1 to rabies virus encephalitis. Journal of Immunology (Baltimore, Md. : 1950). 180: 7506-15. PMID 18490751 DOI: 10.4049/Jimmunol.180.11.7506  0.327
2008 Singh A, Carson WF, Secor ER, Guernsey LA, Flavell RA, Clark RB, Thrall RS, Schramm CM. Regulatory role of B cells in a murine model of allergic airway disease. Journal of Immunology (Baltimore, Md. : 1950). 180: 7318-26. PMID 18490731 DOI: 10.4049/Jimmunol.180.11.7318  0.365
2008 Yang GX, Lian ZX, Chuang YH, Moritoki Y, Lan RY, Wakabayashi K, Ansari AA, Flavell RA, Ridgway WM, Coppel RL, Tsuneyama K, Mackay IR, Gershwin ME. Adoptive transfer of CD8(+) T cells from transforming growth factor beta receptor type II (dominant negative form) induces autoimmune cholangitis in mice. Hepatology (Baltimore, Md.). 47: 1974-82. PMID 18452147 DOI: 10.1002/Hep.22226  0.364
2008 Pappu BP, Borodovsky A, Zheng TS, Yang X, Wu P, Dong X, Weng S, Browning B, Scott ML, Li M, Su L, Tian Q, Schneider P, Flavell RA, Dong C, et al. TL1A-DR3 interaction regulates Th17 cell function and Th17-mediated autoimmune disease Journal of Experimental Medicine. 205: 1049-1062. PMID 18411337 DOI: 10.1084/Jem.20071364  0.365
2008 Couper KN, Blount DG, Wilson MS, Hafalla JC, Belkaid Y, Kamanaka M, Flavell RA, de Souza JB, Riley EM. IL-10 from CD4CD25Foxp3CD127 adaptive regulatory T cells modulates parasite clearance and pathology during malaria infection. Plos Pathogens. 4: e1000004. PMID 18401464 DOI: 10.1371/Journal.Ppat.1000004  0.386
2008 Li MO, Flavell RA. Contextual regulation of inflammation: a duet by transforming growth factor-beta and interleukin-10. Immunity. 28: 468-76. PMID 18400189 DOI: 10.1016/J.Immuni.2008.03.003  0.362
2008 Mohanty S, Town T, Yagi T, Scheidig C, Kwan KY, Allore HG, Flavell RA, Shaw AC. Defective p53 engagement after the induction of DNA damage in cells deficient in topoisomerase 3beta. Proceedings of the National Academy of Sciences of the United States of America. 105: 5063-8. PMID 18367668 DOI: 10.1073/Pnas.0801235105  0.566
2008 Fan TM, Kranz DM, Flavell RA, Roy EJ. Costimulatory strength influences the differential effects of transforming growth factor beta1 for the generation of CD8+ regulatory T cells. Molecular Immunology. 45: 2937-50. PMID 18321576 DOI: 10.1016/J.Molimm.2008.01.019  0.367
2008 Kang SS, Bloom SM, Norian LA, Geske MJ, Flavell RA, Stappenbeck TS, Allen PM. An antibiotic-responsive mouse model of fulminant ulcerative colitis. Plos Medicine. 5: e41. PMID 18318596 DOI: 10.1371/Journal.Pmed.0050041  0.342
2008 Rojo JM, Pini E, Ojeda G, Bello R, Dong C, Flavell RA, Dianzani U, Portolés P. CD4+ICOS+ T lymphocytes inhibit T cell activation 'in vitro' and attenuate autoimmune encephalitis 'in vivo'. International Immunology. 20: 577-89. PMID 18310064 DOI: 10.1093/Intimm/Dxn016  0.377
2008 Hawiger D, Tran E, Du W, Booth CJ, Wen L, Dong C, Flavell RA. ICOS mediates the development of insulin-dependent diabetes mellitus in nonobese diabetic mice. Journal of Immunology (Baltimore, Md. : 1950). 180: 3140-7. PMID 18292537 DOI: 10.4049/Jimmunol.180.5.3140  0.351
2008 Town T, Breunig JJ, Sarkisian MR, Spilianakis C, Ayoub AE, Liu X, Ferrandino AF, Gallagher AR, Li MO, Rakic P, Flavell RA. The stumpy gene is required for mammalian ciliogenesis. Proceedings of the National Academy of Sciences of the United States of America. 105: 2853-8. PMID 18287022 DOI: 10.1073/Pnas.0712385105  0.659
2008 Fukuda K, Tesch GH, Yap FY, Forbes JM, Flavell RA, Davis RJ, Nikolic-Paterson DJ. MKK3 signalling plays an essential role in leukocyte-mediated pancreatic injury in the multiple low-dose streptozotocin model. Laboratory Investigation; a Journal of Technical Methods and Pathology. 88: 398-407. PMID 18283273 DOI: 10.1038/Labinvest.2008.10  0.365
2008 Ou R, Zhang M, Huang L, Flavell RA, Koni PA, Moskophidis D. Regulation of immune response and inflammatory reactions against viral infection by VCAM-1. Journal of Virology. 82: 2952-65. PMID 18216105 DOI: 10.1128/Jvi.02191-07  0.38
2008 Reig N, Jiang A, Couture R, Sutterwala FS, Ogura Y, Flavell RA, Mellman I, van der Goot FG. Maturation modulates caspase-1-independent responses of dendritic cells to Anthrax lethal toxin. Cellular Microbiology. 10: 1190-207. PMID 18194483 DOI: 10.1111/J.1462-5822.2008.01121.X  0.348
2008 Matza D, Badou A, Kobayashi KS, Goldsmith-Pestana K, Masuda Y, Komuro A, McMahon-Pratt D, Marchesi VT, Flavell RA. A scaffold protein, AHNAK1, is required for calcium signaling during T cell activation. Immunity. 28: 64-74. PMID 18191595 DOI: 10.1016/J.Immuni.2007.11.020  0.362
2008 Chuang YH, Lian ZX, Yang GX, Shu SA, Moritoki Y, Ridgway WM, Ansari AA, Kronenberg M, Flavell RA, Gao B, Gershwin ME. Natural killer T cells exacerbate liver injury in a transforming growth factor beta receptor II dominant-negative mouse model of primary biliary cirrhosis. Hepatology (Baltimore, Md.). 47: 571-80. PMID 18098320 DOI: 10.1002/Hep.22052  0.335
2008 Hall HT, Wilhelm MT, Saibil SD, Mak TW, Flavell RA, Ohashi PS. RIP2 contributes to Nod signaling but is not essential for T cell proliferation, T helper differentiation or TLR responses. European Journal of Immunology. 38: 64-72. PMID 18085666 DOI: 10.1002/Eji.200737393  0.395
2008 Pedra JH, Mattner J, Tao J, Kerfoot SM, Davis RJ, Flavell RA, Askenase PW, Yin Z, Fikrig E. c-Jun NH2-terminal kinase 2 inhibits gamma interferon production during Anaplasma phagocytophilum infection. Infection and Immunity. 76: 308-16. PMID 17998313 DOI: 10.1128/Iai.00599-07  0.323
2008 Town T, Laouar Y, Pittenger C, Mori T, Szekely CA, Tan J, Duman RS, Flavell RA. O4-02-06: Blocking Tgf-β-smad 2/3 innate immune signaling mitigates Alzheimer-like pathology in transgenic mice Alzheimer's & Dementia. 4: T187-T188. DOI: 10.1016/J.Jalz.2008.05.514  0.554
2007 Sutterwala FS, Mijares LA, Li L, Ogura Y, Kazmierczak BI, Flavell RA. Immune recognition of Pseudomonas aeruginosa mediated by the IPAF/NLRC4 inflammasome. The Journal of Experimental Medicine. 204: 3235-45. PMID 18070936 DOI: 10.1084/Jem.20071239  0.357
2007 Cameron JS, Alexopoulou L, Sloane JA, DiBernardo AB, Ma Y, Kosaras B, Flavell R, Strittmatter SM, Volpe J, Sidman R, Vartanian T. Toll-like receptor 3 is a potent negative regulator of axonal growth in mammals. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 27: 13033-41. PMID 18032677 DOI: 10.1523/Jneurosci.4290-06.2007  0.305
2007 Willingham SB, Bergstralh DT, O'Connor W, Morrison AC, Taxman DJ, Duncan JA, Barnoy S, Venkatesan MM, Flavell RA, Deshmukh M, Hoffman HM, Ting JP. Microbial pathogen-induced necrotic cell death mediated by the inflammasome components CIAS1/cryopyrin/NLRP3 and ASC. Cell Host & Microbe. 2: 147-59. PMID 18005730 DOI: 10.1016/J.Chom.2007.07.009  0.355
2007 Deane JA, Pisitkun P, Barrett RS, Feigenbaum L, Town T, Ward JM, Flavell RA, Bolland S. Control of toll-like receptor 7 expression is essential to restrict autoimmunity and dendritic cell proliferation. Immunity. 27: 801-10. PMID 17997333 DOI: 10.1016/J.Immuni.2007.09.009  0.585
2007 Awasthi A, Carrier Y, Peron JPS, Bettelli E, Kamanaka M, Flavell RA, Kuchroo VK, Oukka M, Weiner HL. A dominant function for interleukin 27 in generating interleukin 10-producing anti-inflammatory T cells Nature Immunology. 8: 1380-1389. PMID 17994022 DOI: 10.1038/Ni1541  0.39
2007 Wan YY, Flavell RA. 'Yin-Yang' functions of transforming growth factor-beta and T regulatory cells in immune regulation. Immunological Reviews. 220: 199-213. PMID 17979848 DOI: 10.1111/J.1600-065X.2007.00565.X  0.331
2007 Thomas IJ, Petrich de Marquesini LG, Ravanan R, Smith RM, Guerder S, Flavell RA, Wraith DC, Wen L, Wong FS. CD86 has sustained costimulatory effects on CD8 T cells. Journal of Immunology (Baltimore, Md. : 1950). 179: 5936-46. PMID 17947667 DOI: 10.4049/Jimmunol.179.9.5936  0.308
2007 Kim ST, Fields PE, Flavell RA. Demethylation of a specific hypersensitive site in the Th2 locus control region. Proceedings of the National Academy of Sciences of the United States of America. 104: 17052-7. PMID 17940027 DOI: 10.1073/Pnas.0708293104  0.612
2007 Kaplan DH, Li MO, Jenison MC, Shlomchik WD, Flavell RA, Shlomchik MJ. Autocrine/paracrine TGFbeta1 is required for the development of epidermal Langerhans cells. The Journal of Experimental Medicine. 204: 2545-52. PMID 17938236 DOI: 10.1084/Jem.20071401  0.334
2007 Zenewicz LA, Yancopoulos GD, Valenzuela DM, Murphy AJ, Karow M, Flavell RA. Interleukin-22 but not interleukin-17 provides protection to hepatocytes during acute liver inflammation. Immunity. 27: 647-59. PMID 17919941 DOI: 10.1016/J.Immuni.2007.07.023  0.369
2007 Menon S, Chi H, Zhang H, Deng XW, Flavell RA, Wei N. COP9 signalosome subunit 8 is essential for peripheral T cell homeostasis and antigen receptor-induced entry into the cell cycle from quiescence. Nature Immunology. 8: 1236-45. PMID 17906629 DOI: 10.1038/Ni1514  0.387
2007 Das M, Jiang F, Sluss HK, Zhang C, Shokat KM, Flavell RA, Davis RJ. Suppression of p53-dependent senescence by the JNK signal transduction pathway. Proceedings of the National Academy of Sciences of the United States of America. 104: 15759-64. PMID 17893331 DOI: 10.1073/Pnas.0707782104  0.326
2007 Wilson MS, Elnekave E, Mentink-Kane MM, Hodges MG, Pesce JT, Ramalingam TR, Thompson RW, Kamanaka M, Flavell RA, Keane-Myers A, Cheever AW, Wynn TA. IL-13Ralpha2 and IL-10 coordinately suppress airway inflammation, airway-hyperreactivity, and fibrosis in mice. The Journal of Clinical Investigation. 117: 2941-51. PMID 17885690 DOI: 10.1172/Jci31546  0.328
2007 Pedra JH, Sutterwala FS, Sukumaran B, Ogura Y, Qian F, Montgomery RR, Flavell RA, Fikrig E. ASC/PYCARD and caspase-1 regulate the IL-18/IFN-gamma axis during Anaplasma phagocytophilum infection. Journal of Immunology (Baltimore, Md. : 1950). 179: 4783-91. PMID 17878377 DOI: 10.4049/Jimmunol.179.7.4783  0.357
2007 Wrzesinski SH, Wan YY, Flavell RA. Transforming growth factor-beta and the immune response: implications for anticancer therapy. Clinical Cancer Research : An Official Journal of the American Association For Cancer Research. 13: 5262-70. PMID 17875754 DOI: 10.1158/1078-0432.Ccr-07-1157  0.338
2007 Kennedy NJ, Martin G, Ehrhardt AG, Cavanagh-Kyros J, Kuan CY, Rakic P, Flavell RA, Treistman SN, Davis RJ. Requirement of JIP scaffold proteins for NMDA-mediated signal transduction. Genes & Development. 21: 2336-46. PMID 17875667 DOI: 10.1101/Gad.1563107  0.481
2007 Lim JH, Stirling B, Derry J, Koga T, Jono H, Woo CH, Xu H, Bourne P, Ha UH, Ishinaga H, Xu H, Andalibi A, Feng XH, Zhu H, Huang Y, ... ... Flavell RA, et al. Tumor suppressor CYLD regulates acute lung injury in lethal Streptococcus pneumoniae infections. Immunity. 27: 349-60. PMID 17723219 DOI: 10.1016/J.Immuni.2007.07.011  0.313
2007 Watanabe A, Hashmi A, Gomes DA, Town T, Badou A, Flavell RA, Mehal WZ. Apoptotic hepatocyte DNA inhibits hepatic stellate cell chemotaxis via toll-like receptor 9. Hepatology (Baltimore, Md.). 46: 1509-18. PMID 17705260 DOI: 10.1002/Hep.21867  0.593
2007 Ma FY, Tesch GH, Flavell RA, Davis RJ, Nikolic-Paterson DJ. MKK3-p38 signaling promotes apoptosis and the early inflammatory response in the obstructed mouse kidney. American Journal of Physiology. Renal Physiology. 293: F1556-63. PMID 17686961 DOI: 10.1152/Ajprenal.00010.2007  0.31
2007 Amsen D, Antov A, Jankovic D, Sher A, Radtke F, Souabni A, Busslinger M, McCright B, Gridley T, Flavell RA. Direct regulation of Gata3 expression determines the T helper differentiation potential of Notch. Immunity. 27: 89-99. PMID 17658279 DOI: 10.1016/J.Immuni.2007.05.021  0.777
2007 Tong C, Yin Z, Song Z, Dockendorff A, Huang C, Mariadason J, Flavell RA, Davis RJ, Augenlicht LH, Yang W. c-Jun NH2-terminal kinase 1 plays a critical role in intestinal homeostasis and tumor suppression. The American Journal of Pathology. 171: 297-303. PMID 17591974 DOI: 10.2353/Ajpath.2007.061036  0.342
2007 Pedra JH, Tao J, Sutterwala FS, Sukumaran B, Berliner N, Bockenstedt LK, Flavell RA, Yin Z, Fikrig E. IL-12/23p40-dependent clearance of Anaplasma phagocytophilum in the murine model of human anaplasmosis. Fems Immunology and Medical Microbiology. 50: 401-10. PMID 17521390 DOI: 10.1111/J.1574-695X.2007.00270.X  0.375
2007 Fazzari P, Penachioni J, Gianola S, Rossi F, Eickholt BJ, Maina F, Alexopoulou L, Sottile A, Comoglio PM, Flavell RA, Tamagnone L. Plexin-B1 plays a redundant role during mouse development and in tumour angiogenesis. Bmc Developmental Biology. 7: 55. PMID 17519029 DOI: 10.1186/1471-213X-7-55  0.305
2007 Li MO, Wan YY, Flavell RA. T cell-produced transforming growth factor-beta1 controls T cell tolerance and regulates Th1- and Th17-cell differentiation. Immunity. 26: 579-91. PMID 17481928 DOI: 10.1016/J.Immuni.2007.03.014  0.382
2007 Sutterwala FS, Ogura Y, Flavell RA. The inflammasome in pathogen recognition and inflammation. Journal of Leukocyte Biology. 82: 259-64. PMID 17470531 DOI: 10.1189/Jlb.1206755  0.337
2007 Gowen BB, Wong MH, Jung KH, Sanders AB, Mitchell WM, Alexopoulou L, Flavell RA, Sidwell RW. TLR3 is essential for the induction of protective immunity against Punta Toro Virus infection by the double-stranded RNA (dsRNA), poly(I:C12U), but not Poly(I:C): differential recognition of synthetic dsRNA molecules. Journal of Immunology (Baltimore, Md. : 1950). 178: 5200-8. PMID 17404303 DOI: 10.4049/Jimmunol.178.8.5200  0.362
2007 Pan Q, Mathison J, Fearns C, Kravchenko VV, Correia JDS, Hoffman HM, Kobayashi KS, Bertin J, Grant EP, Coyle AJ, Sutterwala FS, Ogura Y, Flavell RA, Ulevitch RJ. MDP-induced interleukin-1β processing requires Nod2 and CIAS1/NALP3 Journal of Leukocyte Biology. 82: 177-183. PMID 17403772 DOI: 10.1189/Jlb.1006627  0.336
2007 Chen L, He W, Kim ST, Tao J, Gao Y, Chi H, Intlekofer AM, Harvey B, Reiner SL, Yin Z, Flavell RA, Craft J. Epigenetic and transcriptional programs lead to default IFN-gamma production by gammadelta T cells. Journal of Immunology (Baltimore, Md. : 1950). 178: 2730-6. PMID 17312115 DOI: 10.4049/Jimmunol.178.5.2730  0.609
2007 Tao J, Gao Y, Li MO, He W, Chen L, Harvev B, Davis RJ, Flavell RA, Yin Z. JNK2 negatively regulates CD8+ T cell effector function and anti-tumor immune response. European Journal of Immunology. 37: 818-29. PMID 17301952 DOI: 10.1002/Eji.200636726  0.369
2007 Jankovic D, Kullberg MC, Feng CG, Goldszmid RS, Collazo CM, Wilson M, Wynn TA, Kamanaka M, Flavell RA, Sher A. Conventional T-bet(+)Foxp3(-) Th1 cells are the major source of host-protective regulatory IL-10 during intracellular protozoan infection. The Journal of Experimental Medicine. 204: 273-83. PMID 17283209 DOI: 10.1084/Jem.20062175  0.376
2007 Wan YY, Flavell RA. Regulatory T-cell functions are subverted and converted owing to attenuated Foxp3 expression. Nature. 445: 766-70. PMID 17220876 DOI: 10.1038/Nature05479  0.374
2007 Bai F, Town T, Pradhan D, Cox J, Ashish, Ledizet M, Anderson JF, Flavell RA, Krueger JK, Koski RA, Fikrig E. Antiviral peptides targeting the west nile virus envelope protein. Journal of Virology. 81: 2047-55. PMID 17151121 DOI: 10.1128/Jvi.01840-06  0.531
2007 Brunelle JK, Shroff EH, Perlman H, Strasser A, Moraes CT, Flavell RA, Danial NN, Keith B, Thompson CB, Chandel NS. Loss of Mcl-1 protein and inhibition of electron transport chain together induce anoxic cell death. Molecular and Cellular Biology. 27: 1222-35. PMID 17145774 DOI: 10.1128/Mcb.01535-06  0.323
2007 Hardarson HS, Baker JS, Yang Z, Purevjav E, Huang CH, Alexopoulou L, Li N, Flavell RA, Bowles NE, Vallejo JG. Toll-like receptor 3 is an essential component of the innate stress response in virus-induced cardiac injury. American Journal of Physiology. Heart and Circulatory Physiology. 292: H251-8. PMID 16936008 DOI: 10.1152/Ajpheart.00398.2006  0.319
2007 Chi H, Bennett AM, Flavell RA. Mitogen-activated protein kinase phosphatase-1 (MKP-1): a critical regulator of innate immune responses Journal of Organ Dysfunction. 3: 72-81. DOI: 10.1080/17471060601137415  0.358
2006 Luo P, Reed BD, Tsang TC, Harris DT, Flavell RA. A self-augmenting gene expression cassette for enhanced and sustained transgene expression in the presence of proinflammatory cytokines. Dna and Cell Biology. 25: 659-67. PMID 17184167 DOI: 10.1089/Dna.2006.25.659  0.316
2006 Sarkisian MR, Bartley CM, Chi H, Nakamura F, Hashimoto-Torii K, Torii M, Flavell RA, Rakic P. MEKK4 signaling regulates filamin expression and neuronal migration. Neuron. 52: 789-801. PMID 17145501 DOI: 10.1016/J.Neuron.2006.10.024  0.499
2006 Kamanaka M, Kim ST, Wan YY, Sutterwala FS, Lara-Tejero M, Galán JE, Harhaj E, Flavell RA. Expression of interleukin-10 in intestinal lymphocytes detected by an interleukin-10 reporter knockin tiger mouse. Immunity. 25: 941-52. PMID 17137799 DOI: 10.1016/J.Immuni.2006.09.013  0.632
2006 Girgenrath M, Weng S, Kostek CA, Browning B, Wang M, Brown SA, Winkles JA, Michaelson JS, Allaire N, Schneider P, Scott ML, Hsu YM, Yagita H, Flavell RA, Miller JB, et al. TWEAK, via its receptor Fn14, is a novel regulator of mesenchymal progenitor cells and skeletal muscle regeneration. The Embo Journal. 25: 5826-39. PMID 17124496 DOI: 10.1038/Sj.Emboj.7601441  0.353
2006 Gowen BB, Hoopes JD, Wong MH, Jung KH, Isakson KC, Alexopoulou L, Flavell RA, Sidwell RW. TLR3 deletion limits mortality and disease severity due to Phlebovirus infection. Journal of Immunology (Baltimore, Md. : 1950). 177: 6301-7. PMID 17056560 DOI: 10.4049/Jimmunol.177.9.6301  0.35
2006 Badou A, Jha MK, Matza D, Mehal WZ, Freichel M, Flockerzi V, Flavell RA. Critical role for the beta regulatory subunits of Cav channels in T lymphocyte function. Proceedings of the National Academy of Sciences of the United States of America. 103: 15529-34. PMID 17028169 DOI: 10.1073/Pnas.0607262103  0.344
2006 Kim SV, Mehal WZ, Dong X, Heinrich V, Pypaert M, Mellman I, Dembo M, Mooseker MS, Wu D, Flavell RA. Modulation of cell adhesion and motility in the immune system by Myo1f. Science (New York, N.Y.). 314: 136-9. PMID 17023661 DOI: 10.1126/Science.1131920  0.37
2006 Wang R, Town T, Gokarn V, Flavell RA, Chandawarkar RY. HSP70 enhances macrophage phagocytosis by interaction with lipid raft-associated TLR-7 and upregulating p38 MAPK and PI3K pathways. The Journal of Surgical Research. 136: 58-69. PMID 16979664 DOI: 10.1016/J.Jss.2006.06.003  0.566
2006 Jaeschke A, Karasarides M, Ventura JJ, Ehrhardt A, Zhang C, Flavell RA, Shokat KM, Davis RJ. JNK2 is a positive regulator of the cJun transcription factor. Molecular Cell. 23: 899-911. PMID 16973441 DOI: 10.1016/J.Molcel.2006.07.028  0.307
2006 Christensen SR, Shupe J, Nickerson K, Kashgarian M, Flavell RA, Shlomchik MJ. Toll-like receptor 7 and TLR9 dictate autoantibody specificity and have opposing inflammatory and regulatory roles in a murine model of lupus. Immunity. 25: 417-28. PMID 16973389 DOI: 10.1016/J.Immuni.2006.07.013  0.335
2006 Li MO, Sanjabi S, Flavell RA. Transforming growth factor-beta controls development, homeostasis, and tolerance of T cells by regulatory T cell-dependent and -independent mechanisms. Immunity. 25: 455-71. PMID 16973386 DOI: 10.1016/J.Immuni.2006.07.011  0.362
2006 Tran EH, Azuma YT, Chen M, Weston C, Davis RJ, Flavell RA. Inactivation of JNK1 enhances innate IL-10 production and dampens autoimmune inflammation in the brain. Proceedings of the National Academy of Sciences of the United States of America. 103: 13451-6. PMID 16938889 DOI: 10.1073/Pnas.0601155103  0.411
2006 Deng JC, Cheng G, Newstead MW, Zeng X, Kobayashi K, Flavell RA, Standiford TJ. Sepsis-induced suppression of lung innate immunity is mediated by IRAK-M. The Journal of Clinical Investigation. 116: 2532-42. PMID 16917541 DOI: 10.1172/Jci28054  0.319
2006 Wan YY, Flavell RA. The roles for cytokines in the generation and maintenance of regulatory T cells. Immunological Reviews. 212: 114-30. PMID 16903910 DOI: 10.1111/J.0105-2896.2006.00407.X  0.394
2006 Feuillet V, Medjane S, Mondor I, Demaria O, Pagni PP, Galán JE, Flavell RA, Alexopoulou L. Involvement of Toll-like receptor 5 in the recognition of flagellated bacteria. Proceedings of the National Academy of Sciences of the United States of America. 103: 12487-92. PMID 16891416 DOI: 10.1073/Pnas.0605200103  0.323
2006 Oertelt S, Lian ZX, Cheng CM, Chuang YH, Padgett KA, He XS, Ridgway WM, Ansari AA, Coppel RL, Li MO, Flavell RA, Kronenberg M, Mackay IR, Gershwin ME. Anti-mitochondrial antibodies and primary biliary cirrhosis in TGF-beta receptor II dominant-negative mice. Journal of Immunology (Baltimore, Md. : 1950). 177: 1655-60. PMID 16849474 DOI: 10.4049/Jimmunol.177.3.1655  0.367
2006 Wan YY, Chi H, Xie M, Schneider MD, Flavell RA. The kinase TAK1 integrates antigen and cytokine receptor signaling for T cell development, survival and function. Nature Immunology. 7: 851-8. PMID 16799562 DOI: 10.1038/Ni1355  0.383
2006 Le Goffic R, Balloy V, Lagranderie M, Alexopoulou L, Escriou N, Flavell R, Chignard M, Si-Tahar M. Detrimental contribution of the Toll-like receptor (TLR)3 to influenza A virus-induced acute pneumonia. Plos Pathogens. 2: e53. PMID 16789835 DOI: 10.1371/Journal.Ppat.0020053  0.362
2006 Canaan A, Yu X, Booth CJ, Lian J, Lazar I, Gamfi SL, Castille K, Kohya N, Nakayama Y, Liu YC, Eynon E, Flavell R, Weissman SM. FAT10/diubiquitin-like protein-deficient mice exhibit minimal phenotypic differences. Molecular and Cellular Biology. 26: 5180-9. PMID 16782901 DOI: 10.1128/Mcb.00966-05  0.34
2006 Lara-Tejero M, Sutterwala FS, Ogura Y, Grant EP, Bertin J, Coyle AJ, Flavell RA, Galán JE. Role of the caspase-1 inflammasome in Salmonella typhimurium pathogenesis. The Journal of Experimental Medicine. 203: 1407-12. PMID 16717117 DOI: 10.1084/Jem.20060206  0.314
2006 Gitlin L, Barchet W, Gilfillan S, Cella M, Beutler B, Flavell RA, Diamond MS, Colonna M. Essential role of mda-5 in type I IFN responses to polyriboinosinic:polyribocytidylic acid and encephalomyocarditis picornavirus. Proceedings of the National Academy of Sciences of the United States of America. 103: 8459-64. PMID 16714379 DOI: 10.1073/Pnas.0603082103  0.343
2006 Du W, Wong FS, Li MO, Peng J, Qi H, Flavell RA, Sherwin R, Wen L. TGF-β signaling is required for the function of insulin-reactive T regulatory cells Journal of Clinical Investigation. 116: 1360-1370. PMID 16670772 DOI: 10.1172/Jci27030  0.355
2006 Ma B, Blackburn MR, Lee CG, Homer RJ, Liu W, Flavell RA, Boyden L, Lifton RP, Sun CX, Young HW, Elias JA. Adenosine metabolism and murine strain-specific IL-4-induced inflammation, emphysema, and fibrosis. The Journal of Clinical Investigation. 116: 1274-83. PMID 16670768 DOI: 10.1172/Jci26372  0.35
2006 Abonia JP, Hallgren J, Jones T, Shi T, Xu Y, Koni P, Flavell RA, Boyce JA, Austen KF, Gurish MF. Alpha-4 integrins and VCAM-1, but not MAdCAM-1, are essential for recruitment of mast cell progenitors to the inflamed lung. Blood. 108: 1588-94. PMID 16670268 DOI: 10.1182/Blood-2005-12-012781  0.312
2006 Lee GR, Kim ST, Spilianakis CG, Fields PE, Flavell RA. T helper cell differentiation: regulation by cis elements and epigenetics. Immunity. 24: 369-79. PMID 16618596 DOI: 10.1016/J.Immuni.2006.03.007  0.603
2006 Matalova E, Sharpe PT, Lakhani SA, Roth KA, Flavell RA, Setkova J, Misek I, Tucker AS. Molar tooth development in caspase-3 deficient mice. The International Journal of Developmental Biology. 50: 491-7. PMID 16586350 DOI: 10.1387/Ijdb.052117Em  0.303
2006 Kriegel MA, Li MO, Sanjabi S, Wan YY, Flavell RA. Transforming growth factor-beta: recent advances on its role in immune tolerance. Current Rheumatology Reports. 8: 138-44. PMID 16569373 DOI: 10.1007/S11926-006-0054-Y  0.314
2006 Inoue T, Boyle DL, Corr M, Hammaker D, Davis RJ, Flavell RA, Firestein GS. Mitogen-activated protein kinase kinase 3 is a pivotal pathway regulating p38 activation in inflammatory arthritis. Proceedings of the National Academy of Sciences of the United States of America. 103: 5484-9. PMID 16567640 DOI: 10.1073/Pnas.0509188103  0.35
2006 Pan Q, Kravchenko V, Katz A, Huang S, Ii M, Mathison JC, Kobayashi K, Flavell RA, Schreiber RD, Goeddel D, Ulevitch RJ. NF-kappa B-inducing kinase regulates selected gene expression in the Nod2 signaling pathway. Infection and Immunity. 74: 2121-7. PMID 16552041 DOI: 10.1128/Iai.74.4.2121-2127.2006  0.374
2006 Li MO, Wan YY, Sanjabi S, Robertson AK, Flavell RA. Transforming growth factor-beta regulation of immune responses. Annual Review of Immunology. 24: 99-146. PMID 16551245 DOI: 10.1146/Annurev.Immunol.24.021605.090737  0.319
2006 Sutterwala FS, Ogura Y, Szczepanik M, Lara-Tejero M, Lichtenberger GS, Grant EP, Bertin J, Coyle AJ, Galán JE, Askenase PW, Flavell RA. Critical role for NALP3/CIAS1/Cryopyrin in innate and adaptive immunity through its regulation of caspase-1. Immunity. 24: 317-27. PMID 16546100 DOI: 10.1016/J.Immuni.2006.02.004  0.369
2006 Town T, Jeng D, Alexopoulou L, Tan J, Flavell RA. Microglia recognize double-stranded RNA via TLR3. Journal of Immunology (Baltimore, Md. : 1950). 176: 3804-12. PMID 16517751 DOI: 10.4049/Jimmunol.176.6.3804  0.592
2006 Chi H, Barry SP, Roth RJ, Wu JJ, Jones EA, Bennett AM, Flavell RA. Dynamic regulation of pro- and anti-inflammatory cytokines by MAPK phosphatase 1 (MKP-1) in innate immune responses. Proceedings of the National Academy of Sciences of the United States of America. 103: 2274-9. PMID 16461893 DOI: 10.1073/Pnas.0510965103  0.372
2006 Querec T, Bennouna S, Alkan S, Laouar Y, Gorden K, Flavell R, Akira S, Ahmed R, Pulendran B. Yellow fever vaccine YF-17D activates multiple dendritic cell subsets via TLR2, 7, 8, and 9 to stimulate polyvalent immunity. The Journal of Experimental Medicine. 203: 413-24. PMID 16461338 DOI: 10.1084/Jem.20051720  0.353
2006 Wu W, Misra RS, Russell JQ, Flavell RA, Rincón M, Budd RC. Proteolytic regulation of nuclear factor of activated T (NFAT) c2 cells and NFAT activity by caspase-3 Journal of Biological Chemistry. 281: 10682-10690. PMID 16455648 DOI: 10.1074/Jbc.M511759200  0.372
2006 Zamboni DS, Kobayashi KS, Kohlsdorf T, Ogura Y, Long EM, Vance RE, Kuida K, Mariathasan S, Dixit VM, Flavell RA, Dietrich WF, Roy CR. The Birc1e cytosolic pattern-recognition receptor contributes to the detection and control of Legionella pneumophila infection. Nature Immunology. 7: 318-25. PMID 16444259 DOI: 10.1038/Ni1305  0.352
2006 Rudd BD, Smit JJ, Flavell RA, Alexopoulou L, Schaller MA, Gruber A, Berlin AA, Lukacs NW. Deletion of TLR3 alters the pulmonary immune environment and mucus production during respiratory syncytial virus infection. Journal of Immunology (Baltimore, Md. : 1950). 176: 1937-42. PMID 16424225 DOI: 10.4049/Jimmunol.176.3.1937  0.359
2006 Wohlfert EA, Gorelik L, Mittler R, Flavell RA, Clark RB. Cutting edge: Deficiency in the E3 ubiquitin ligase Cbl-b results in a multifunctional defect in T cell TGF-β sensitivity in vitro and in vivo Journal of Immunology. 176: 1316-1320. PMID 16424156 DOI: 10.4049/Jimmunol.176.3.1316  0.333
2006 Millet I, Wong FS, Gurr W, Wen L, Zawalich W, Green EA, Flavell RA, Sherwin RS. Targeted expression of the anti-apoptotic gene CrmA to NOD pancreatic islets protects from autoimmune diabetes. Journal of Autoimmunity. 26: 7-15. PMID 16338119 DOI: 10.1016/J.Jaut.2005.10.005  0.364
2006 Mitchell JE, Cvetanovic M, Tibrewal N, Patel V, Colamonici OR, Li MO, Flavell RA, Levine JS, Birge RB, Ucker DS. The presumptive phosphatidylserine receptor is dispensable for innate anti-inflammatory recognition and clearance of apoptotic cells. The Journal of Biological Chemistry. 281: 5718-25. PMID 16317002 DOI: 10.1074/Jbc.M509775200  0.369
2006 Jones EA, Flavell RA. Distal enhancer elements transcribe intergenic RNA in the IL-10 family gene cluster. Journal of Immunology (Baltimore, Md. : 1950). 175: 7437-46. PMID 16301651 DOI: 10.4049/Jimmunol.175.11.7437  0.341
2006 Buch T, Polic B, Clausen BE, Weiss S, Akilli-Ozturk O, Chang CH, Flavell R, Schulz A, Jonjic S, Waisman A, Förster I. MHC class II expression through a hitherto unknown pathway supports T helper cell-dependent immune responses: implications for MHC class II deficiency. Blood. 107: 1434-44. PMID 16254146 DOI: 10.1182/Blood-2004-09-3445  0.384
2005 Liu L, Tran E, Zhao Y, Huang Y, Flavell R, Lu B. Gadd45 beta and Gadd45 gamma are critical for regulating autoimmunity. The Journal of Experimental Medicine. 202: 1341-7. PMID 16287712 DOI: 10.1084/Jem.20051359  0.395
2005 Lau CM, Broughton C, Tabor AS, Akira S, Flavell RA, Mamula MJ, Christensen SR, Shlomchik MJ, Viglianti GA, Rifkin IR, Marshak-Rothstein A. RNA-associated autoantigens activate B cells by combined B cell antigen receptor/Toll-like receptor 7 engagement. The Journal of Experimental Medicine. 202: 1171-7. PMID 16260486 DOI: 10.1084/Jem.20050630  0.329
2005 Town T, Tan J, Flavell RA, Mullan M. T-cells in Alzheimer's disease. Neuromolecular Medicine. 7: 255-64. PMID 16247185 DOI: 10.1385/Nmm:7:3:255  0.661
2005 Gao Y, Tao J, Li MO, Zhang D, Chi H, Henegariu O, Kaech SM, Davis RJ, Flavell RA, Yin Z. JNK1 is essential for CD8+ T cell-mediated tumor immune surveillance. Journal of Immunology (Baltimore, Md. : 1950). 175: 5783-9. PMID 16237070 DOI: 10.4049/Jimmunol.175.9.5783  0.372
2005 Aoki CA, Borchers AT, Li M, Flavell RA, Bowlus CL, Ansari AA, Gershwin ME. Transforming growth factor beta (TGF-beta) and autoimmunity. Autoimmunity Reviews. 4: 450-9. PMID 16137611 DOI: 10.1016/J.Autrev.2005.03.006  0.347
2005 Christensen SR, Kashgarian M, Alexopoulou L, Flavell RA, Akira S, Shlomchik MJ. Toll-like receptor 9 controls anti-DNA autoantibody production in murine lupus. The Journal of Experimental Medicine. 202: 321-31. PMID 16027240 DOI: 10.1084/Jem.20050338  0.341
2005 Shen TL, Park AY, Alcaraz A, Peng X, Jang I, Koni P, Flavell RA, Gu H, Guan JL. Conditional knockout of focal adhesion kinase in endothelial cells reveals its role in angiogenesis and vascular development in late embryogenesis. The Journal of Cell Biology. 169: 941-52. PMID 15967814 DOI: 10.1083/Jcb.200411155  0.305
2005 Kimberly WT, Zheng JB, Town T, Flavell RA, Selkoe DJ. Physiological regulation of the beta-amyloid precursor protein signaling domain by c-Jun N-terminal kinase JNK3 during neuronal differentiation. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 25: 5533-43. PMID 15944381 DOI: 10.1523/Jneurosci.4883-04.2005  0.565
2005 Zheng T, Kang MJ, Crothers K, Zhu Z, Liu W, Lee CG, Rabach LA, Chapman HA, Homer RJ, Aldous D, De Sanctis GT, Desanctis G, Underwood S, Graupe M, Flavell RA, et al. Role of cathepsin S-dependent epithelial cell apoptosis in IFN-gamma-induced alveolar remodeling and pulmonary emphysema. Journal of Immunology (Baltimore, Md. : 1950). 174: 8106-15. PMID 15944319 DOI: 10.4049/Jimmunol.174.12.8106  0.335
2005 Jimi E, Phillips RJ, Rincon M, Voll R, Karasuyama H, Flavell R, Ghosh S. Activation of NF-kappaB promotes the transition of large, CD43+ pre-B cells to small, CD43- pre-B cells. International Immunology. 17: 815-25. PMID 15908447 DOI: 10.1093/Intimm/Dxh263  0.343
2005 Spilianakis CG, Lalioti MD, Town T, Lee GR, Flavell RA. Interchromosomal associations between alternatively expressed loci. Nature. 435: 637-45. PMID 15880101 DOI: 10.1038/Nature03574  0.614
2005 Yarovinsky F, Zhang D, Andersen JF, Bannenberg GL, Serhan CN, Hayden MS, Hieny S, Sutterwala FS, Flavell RA, Ghosh S, Sher A. TLR11 activation of dendritic cells by a protozoan profilin-like protein. Science (New York, N.Y.). 308: 1626-9. PMID 15860593 DOI: 10.1126/Science.1109893  0.354
2005 Laouar Y, Sutterwala FS, Gorelik L, Flavell RA. Transforming growth factor-beta controls T helper type 1 cell development through regulation of natural killer cell interferon-gamma. Nature Immunology. 6: 600-7. PMID 15852008 DOI: 10.1038/Ni1197  0.358
2005 Li Y, Schwabe RF, DeVries-Seimon T, Yao PM, Gerbod-Giannone MC, Tall AR, Davis RJ, Flavell R, Brenner DA, Tabas I. Free cholesterol-loaded macrophages are an abundant source of tumor necrosis factor-alpha and interleukin-6: model of NF-kappaB- and map kinase-dependent inflammation in advanced atherosclerosis. The Journal of Biological Chemistry. 280: 21763-72. PMID 15826936 DOI: 10.1074/Jbc.M501759200  0.326
2005 Mehal WZ, Sheikh SZ, Gorelik L, Flavell RA. TGF-beta signaling regulates CD8+ T cell responses to high- and low-affinity TCR interactions. International Immunology. 17: 531-8. PMID 15824070 DOI: 10.1093/Intimm/Dxh233  0.363
2005 Li H, Cuartas E, Cui W, Choi Y, Crawford TD, Hua ZK, Kobayashi KS, Flavell RA, Vignery A. IL-1 receptor-associated kinase M is a central regulator of osteoclast differentiation and activation Journal of Experimental Medicine. 201: 1169-1177. PMID 15809356 DOI: 10.1084/Jem.20041444  0.312
2005 Wan YY, Flavell RA. Identifying Foxp3-expressing suppressor T cells with a bicistronic reporter. Proceedings of the National Academy of Sciences of the United States of America. 102: 5126-31. PMID 15795373 DOI: 10.1073/Pnas.0501701102  0.386
2005 Kim L, Del Rio L, Butcher BA, Mogensen TH, Paludan SR, Flavell RA, Denkers EY. p38 MAPK autophosphorylation drives macrophage IL-12 production during intracellular infection. Journal of Immunology (Baltimore, Md. : 1950). 174: 4178-84. PMID 15778378 DOI: 10.4049/Jimmunol.174.7.4178  0.32
2005 Gangwani L, Flavell RA, Davis RJ. ZPR1 is essential for survival and is required for localization of the survival motor neurons (SMN) protein to Cajal bodies. Molecular and Cellular Biology. 25: 2744-56. PMID 15767679 DOI: 10.1128/Mcb.25.7.2744-2756.2005  0.309
2005 Fahlén L, Read S, Gorelik L, Hurst SD, Coffman RL, Flavell RA, Powrie F. T cells that cannot respond to TGF-beta escape control by CD4(+)CD25(+) regulatory T cells. The Journal of Experimental Medicine. 201: 737-46. PMID 15753207 DOI: 10.1084/Jem.20040685  0.35
2005 Chi H, Sarkisian MR, Rakic P, Flavell RA. Loss of mitogen-activated protein kinase kinase kinase 4 (MEKK4) results in enhanced apoptosis and defective neural tube development. Proceedings of the National Academy of Sciences of the United States of America. 102: 3846-51. PMID 15731347 DOI: 10.1073/Pnas.0500026102  0.504
2005 Chi H, Flavell RA. Cutting edge: regulation of T cell trafficking and primary immune responses by sphingosine 1-phosphate receptor 1. Journal of Immunology (Baltimore, Md. : 1950). 174: 2485-8. PMID 15728452 DOI: 10.4049/Jimmunol.174.5.2485  0.371
2005 Kwon H, Jun HS, Yang Y, Mora C, Mariathasan S, Ohashi PS, Flavell RA, Yoon JW. Development of autoreactive diabetogenic T cells in the thymus of NOD mice. Journal of Autoimmunity. 24: 11-23. PMID 15725572 DOI: 10.1016/J.Jaut.2004.10.002  0.363
2005 Schulz O, Diebold SS, Chen M, Näslund TI, Nolte MA, Alexopoulou L, Azuma YT, Flavell RA, Liljeström P, Reis e Sousa C. Toll-like receptor 3 promotes cross-priming to virus-infected cells. Nature. 433: 887-92. PMID 15711573 DOI: 10.1038/Nature03326  0.373
2005 Bynoe MS, Viret C, Flavell RA, Janeway CA. T cells from epicutaneously immunized mice are prone to T cell receptor revision. Proceedings of the National Academy of Sciences of the United States of America. 102: 2898-903. PMID 15708975 DOI: 10.1073/Pnas.0409880102  0.405
2005 Abonia JP, Austen KF, Rollins BJ, Joshi SK, Flavell RA, Kuziel WA, Koni PA, Gurish MF. Constitutive homing of mast cell progenitors to the intestine depends on autologous expression of the chemokine receptor CXCR2. Blood. 105: 4308-13. PMID 15705791 DOI: 10.1182/Blood-2004-09-3578  0.319
2005 Kobayashi KS, Chamaillard M, Ogura Y, Henegariu O, Inohara N, Nuñez G, Flavell RA. Nod2-dependent regulation of innate and adaptive immunity in the intestinal tract. Science (New York, N.Y.). 307: 731-4. PMID 15692051 DOI: 10.1126/Science.1104911  0.333
2005 Townsend KP, Town T, Mori T, Lue LF, Shytle D, Sanberg PR, Morgan D, Fernandez F, Flavell RA, Tan J. CD40 signaling regulates innate and adaptive activation of microglia in response to amyloid beta-peptide. European Journal of Immunology. 35: 901-10. PMID 15688347 DOI: 10.1002/Eji.200425585  0.58
2004 Chen ML, Pittet MJ, Gorelik L, Flavell RA, Weissleder R, von Boehmer H, Khazaie K. Regulatory T cells suppress tumor-specific CD8 T cell cytotoxicity through TGF-beta signals in vivo. Proceedings of the National Academy of Sciences of the United States of America. 102: 419-24. PMID 15623559 DOI: 10.1073/Pnas.0408197102  0.343
2004 Miura M, Chen XD, Allen MR, Bi Y, Gronthos S, Seo BM, Lakhani S, Flavell RA, Feng XH, Robey PG, Young M, Shi S. A crucial role of caspase-3 in osteogenic differentiation of bone marrow stromal stem cells. The Journal of Clinical Investigation. 114: 1704-13. PMID 15599395 DOI: 10.1172/Jci20427  0.318
2004 Fields PE, Lee GR, Kim ST, Bartsevich VV, Flavell RA. Th2-specific chromatin remodeling and enhancer activity in the Th2 cytokine locus control region. Immunity. 21: 865-76. PMID 15589174 DOI: 10.1016/J.Immuni.2004.10.015  0.597
2004 Kuan CY, Schloemer AJ, Lu A, Burns KA, Weng WL, Williams MT, Strauss KI, Vorhees CV, Flavell RA, Davis RJ, Sharp FR, Rakic P. Hypoxia-ischemia induces DNA synthesis without cell proliferation in dying neurons in adult rodent brain. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 24: 10763-72. PMID 15564594 DOI: 10.1523/Jneurosci.3883-04.2004  0.503
2004 Wang T, Town T, Alexopoulou L, Anderson JF, Fikrig E, Flavell RA. Toll-like receptor 3 mediates West Nile virus entry into the brain causing lethal encephalitis. Nature Medicine. 10: 1366-73. PMID 15558055 DOI: 10.1038/Nm1140  0.571
2004 López CB, Moltedo B, Alexopoulou L, Bonifaz L, Flavell RA, Moran TM. TLR-independent induction of dendritic cell maturation and adaptive immunity by negative-strand RNA viruses. Journal of Immunology (Baltimore, Md. : 1950). 173: 6882-9. PMID 15557183 DOI: 10.4049/Jimmunol.173.11.6882  0.333
2004 Ventura JJ, Cogswell P, Flavell RA, Baldwin AS, Davis RJ. JNK potentiates TNF-stimulated necrosis by increasing the production of cytotoxic reactive oxygen species. Genes & Development. 18: 2905-15. PMID 15545623 DOI: 10.1101/Gad.1223004  0.309
2004 Gao Y, Qian WP, Dark K, Toraldo G, Lin AS, Guldberg RE, Flavell RA, Weitzmann MN, Pacifici R. Estrogen prevents bone loss through transforming growth factor beta signaling in T cells. Proceedings of the National Academy of Sciences of the United States of America. 101: 16618-23. PMID 15531637 DOI: 10.1073/Pnas.0404888101  0.308
2004 Young HY, Zucker P, Flavell RA, Jevnikar AM, Singh B. Characterization of the role of major histocompatibility complex in type 1 diabetes recurrence after islet transplantation. Transplantation. 78: 509-15. PMID 15446308 DOI: 10.1097/01.Tp.0000128907.83111.C6  0.308
2004 Weston CR, Wong A, Hall JP, Goad MEP, Flavell RA, Davis RJ. The c-Jun NH2-terminal kinase is essential for epidermal growth factor expression during epidermal morphogenesis Proceedings of the National Academy of Sciences of the United States of America. 101: 14114-14119. PMID 15375216 DOI: 10.1073/Pnas.0406061101  0.354
2004 Zhang Y, Blattman JN, Kennedy NJ, Duong J, Nguyen T, Wang Y, Davis RJ, Greenberg PD, Flavell RA, Dong C. Regulation of innate and adaptive immune responses by MAP kinase phosphatase 5. Nature. 430: 793-7. PMID 15306813 DOI: 10.1038/Nature02764  0.38
2004 Scott BG, Yang H, Tüzün E, Dong C, Flavell RA, Christadoss P. ICOS is essential for the development of experimental autoimmune myasthenia gravis. Journal of Neuroimmunology. 153: 16-25. PMID 15265659 DOI: 10.1016/J.Jneuroim.2004.04.019  0.358
2004 Amsen D, Blander JM, Lee GR, Tanigaki K, Honjo T, Flavell RA. Instruction of distinct CD4 T helper cell fates by different notch ligands on antigen-presenting cells. Cell. 117: 515-26. PMID 15137944 DOI: 10.1016/S0092-8674(04)00451-9  0.387
2004 Edelmann KH, Richardson-Burns S, Alexopoulou L, Tyler KL, Flavell RA, Oldstone MB. Does Toll-like receptor 3 play a biological role in virus infections? Virology. 322: 231-8. PMID 15110521 DOI: 10.1016/J.Virol.2004.01.033  0.306
2004 Behrens GM, Li M, Davey GM, Allison J, Flavell RA, Carbone FR, Heath WR. Helper requirements for generation of effector CTL to islet beta cell antigens. Journal of Immunology (Baltimore, Md. : 1950). 172: 5420-6. PMID 15100283 DOI: 10.4049/Jimmunol.172.9.5420  0.374
2004 Peng Y, Laouar Y, Li MO, Green EA, Flavell RA. TGF-beta regulates in vivo expansion of Foxp3-expressing CD4+CD25+ regulatory T cells responsible for protection against diabetes. Proceedings of the National Academy of Sciences of the United States of America. 101: 4572-7. PMID 15070759 DOI: 10.1073/Pnas.0400810101  0.349
2004 Chi H, Lu B, Takekawa M, Davis RJ, Flavell RA. GADD45beta/GADD45gamma and MEKK4 comprise a genetic pathway mediating STAT4-independent IFNgamma production in T cells. The Embo Journal. 23: 1576-86. PMID 15044949 DOI: 10.1038/Sj.Emboj.7600173  0.403
2004 Lund JM, Alexopoulou L, Sato A, Karow M, Adams NC, Gale NW, Iwasaki A, Flavell RA. Recognition of single-stranded RNA viruses by Toll-like receptor 7. Proceedings of the National Academy of Sciences of the United States of America. 101: 5598-603. PMID 15034168 DOI: 10.1073/Pnas.0400937101  0.316
2004 Zhang D, Zhang G, Hayden MS, Greenblatt MB, Bussey C, Flavell RA, Ghosh S. A toll-like receptor that prevents infection by uropathogenic bacteria. Science (New York, N.Y.). 303: 1522-6. PMID 15001781 DOI: 10.1126/Science.1094351  0.323
2004 Tabeta K, Georgel P, Janssen E, Du X, Hoebe K, Crozat K, Mudd S, Shamel L, Sovath S, Goode J, Alexopoulou L, Flavell RA, Beutler B. Toll-like receptors 9 and 3 as essential components of innate immune defense against mouse cytomegalovirus infection. Proceedings of the National Academy of Sciences of the United States of America. 101: 3516-21. PMID 14993594 DOI: 10.1073/Pnas.0400525101  0.355
2004 Christen U, Darwiche R, Thomas HE, Wolfe T, Rodrigo E, Chervonsky A, Flavell RA, von Herrath MG. Virally induced inflammation triggers fratricide of Fas-ligand-expressing beta-cells. Diabetes. 53: 591-6. PMID 14988242 DOI: 10.2337/Diabetes.53.3.591  0.335
2004 Lu B, Zagouras P, Fischer JE, Lu J, Li B, Flavell RA. Kinetic analysis of genomewide gene expression reveals molecule circuitries that control T cell activation and Th1/2 differentiation. Proceedings of the National Academy of Sciences of the United States of America. 101: 3023-8. PMID 14978277 DOI: 10.1073/Pnas.0307743100  0.335
2004 Song R, Mahidhara RS, Zhou Z, Hoffman RA, Seol DW, Flavell RA, Billiar TR, Otterbein LE, Choi AM. Carbon monoxide inhibits T lymphocyte proliferation via caspase-dependent pathway. Journal of Immunology (Baltimore, Md. : 1950). 172: 1220-6. PMID 14707100 DOI: 10.4049/Jimmunol.172.2.1220  0.35
2004 Hunot S, Vila M, Teismann P, Davis RJ, Hirsch EC, Przedborski S, Rakic P, Flavell RA. JNK-mediated induction of cyclooxygenase 2 is required for neurodegeneration in a mouse model of Parkinson's disease. Proceedings of the National Academy of Sciences of the United States of America. 101: 665-70. PMID 14704277 DOI: 10.1073/Pnas.0307453101  0.48
2004 Zheng WP, Zhao Q, Zhao X, Li B, Hubank M, Schatz DG, Flavell RA. Up-regulation of Hlx in immature Th cells induces IFN-gamma expression. Journal of Immunology (Baltimore, Md. : 1950). 172: 114-22. PMID 14688316 DOI: 10.4049/Jimmunol.172.1.114  0.392
2004 Eshima K, Choi Y, Flavell RA. CD154-CD40-independent up-regulation of B7-2 on splenic antigen-presenting cells and efficient T cell priming by staphylococcal enterotoxin A. International Immunology. 15: 817-26. PMID 12807820 DOI: 10.1093/Intimm/Dxg080  0.328
2003 Laouar Y, Welte T, Fu XY, Flavell RA. STAT3 is required for Flt3L-dependent dendritic cell differentiation. Immunity. 19: 903-12. PMID 14670306 DOI: 10.1016/S1074-7613(03)00332-7  0.304
2003 Serbina NV, Kuziel W, Flavell R, Akira S, Rollins B, Pamer EG. Sequential MyD88-independent and -dependent activation of innate immune responses to intracellular bacterial infection. Immunity. 19: 891-901. PMID 14670305 DOI: 10.1016/S1074-7613(03)00330-3  0.319
2003 Hernandez LD, Pypaert M, Flavell RA, Galán JE. A Salmonella protein causes macrophage cell death by inducing autophagy. The Journal of Cell Biology. 163: 1123-31. PMID 14662750 DOI: 10.1083/Jcb.200309161  0.315
2003 Kuan CY, Whitmarsh AJ, Yang DD, Liao G, Schloemer AJ, Dong C, Bao J, Banasiak KJ, Haddad GG, Flavell RA, Davis RJ, Rakic P. A critical role of neural-specific JNK3 for ischemic apoptosis. Proceedings of the National Academy of Sciences of the United States of America. 100: 15184-9. PMID 14657393 DOI: 10.1073/Pnas.2336254100  0.497
2003 Li MO, Sarkisian MR, Mehal WZ, Rakic P, Flavell RA. Phosphatidylserine receptor is required for clearance of apoptotic cells. Science (New York, N.Y.). 302: 1560-3. PMID 14645847 DOI: 10.1126/Science.1087621  0.533
2003 Xiao C, Shim JH, Klüppel M, Zhang SS, Dong C, Flavell RA, Fu XY, Wrana JL, Hogan BL, Ghosh S. Ecsit is required for Bmp signaling and mesoderm formation during mouse embryogenesis. Genes & Development. 17: 2933-49. PMID 14633973 DOI: 10.1101/Gad.1145603  0.319
2003 Otterbein LE, Otterbein SL, Ifedigbo E, Liu F, Morse DE, Fearns C, Ulevitch RJ, Knickelbein R, Flavell RA, Choi AM. MKK3 Mitogen-Activated Protein Kinase Pathway Mediates Carbon Monoxide-Induced Protection Against Oxidant-Induced Lung Injury American Journal of Pathology. 163: 2555-2563. PMID 14633627 DOI: 10.1016/S0002-9440(10)63610-3  0.315
2003 Hoebe K, Janssen EM, Kim SO, Alexopoulou L, Flavell RA, Han J, Beutler B. Upregulation of costimulatory molecules induced by lipopolysaccharide and double-stranded RNA occurs by Trif-dependent and Trif-independent pathways. Nature Immunology. 4: 1223-9. PMID 14625548 DOI: 10.1038/Ni1010  0.32
2003 Kano A, Wolfgang MJ, Gao Q, Jacoby J, Chai GX, Hansen W, Iwamoto Y, Pober JS, Flavell RA, Fu XY. Endothelial cells require STAT3 for protection against endotoxin-induced inflammation. The Journal of Experimental Medicine. 198: 1517-25. PMID 14623907 DOI: 10.1084/Jem.20030077  0.366
2003 Green EA, Gorelik L, McGregor CM, Tran EH, Flavell RA. CD4+CD25+ T regulatory cells control anti-islet CD8+ T cells through TGF-beta-TGF-beta receptor interactions in type 1 diabetes. Proceedings of the National Academy of Sciences of the United States of America. 100: 10878-83. PMID 12949259 DOI: 10.1073/Pnas.1834400100  0.331
2003 Kelkar N, Delmotte MH, Weston CR, Barrett T, Sheppard BJ, Flavell RA, Davis RJ. Morphogenesis of the telencephalic commissure requires scaffold protein JNK-interacting protein 3 (JIP3). Proceedings of the National Academy of Sciences of the United States of America. 100: 9843-8. PMID 12897243 DOI: 10.1073/Pnas.1733944100  0.308
2003 Lee GR, Fields PE, Griffin TJ, Flavell RA. Regulation of the Th2 cytokine locus by a locus control region. Immunity. 19: 145-53. PMID 12871646 DOI: 10.1016/S1074-7613(03)00179-1  0.36
2003 Lamb JA, Ventura JJ, Hess P, Flavell RA, Davis RJ. JunD mediates survival signaling by the JNK signal transduction pathway. Molecular Cell. 11: 1479-89. PMID 12820962 DOI: 10.1016/S1097-2765(03)00203-X  0.309
2003 Diebold SS, Montoya M, Unger H, Alexopoulou L, Roy P, Haswell LE, Al-Shamkhani A, Flavell R, Borrow P, Reis e Sousa C. Viral infection switches non-plasmacytoid dendritic cells into high interferon producers. Nature. 424: 324-8. PMID 12819664 DOI: 10.1038/Nature01783  0.353
2003 Nurieva RI, Duong J, Kishikawa H, Dianzani U, Rojo JM, Ho Ic, Flavell RA, Dong C. Transcriptional regulation of th2 differentiation by inducible costimulator. Immunity. 18: 801-11. PMID 12818161 DOI: 10.1016/S1074-7613(03)00144-4  0.392
2003 Weston CR, Wong A, Hall JP, Goad MEP, Flavell RA, Davis RJ. JNK initiates a cytokine cascade that causes Pax2 expression and closure of the optic fissure Genes and Development. 17: 1271-1280. PMID 12756228 DOI: 10.1101/Gad.1087303  0.316
2003 Czyzyk J, Brogdon JL, Badou A, Henegariu O, Preston Hurlburt P, Flavell R, Bottomly K. Activation of CD4 T cells by Raf-independent effectors of Ras. Proceedings of the National Academy of Sciences of the United States of America. 100: 6003-8. PMID 12721365 DOI: 10.1073/Pnas.1031494100  0.328
2003 Ventura JJ, Kennedy NJ, Lamb JA, Flavell RA, Davis RJ. c-Jun NH2-terminal kinase is essential for the regulation of AP-1 by tumor necrosis factor Molecular and Cellular Biology. 23: 2871-2882. PMID 12665585 DOI: 10.1128/Mcb.23.8.2871-2882.2003  0.324
2003 Carambula SF, Pru JK, Lynch MP, Matikainen T, Gonçalves PB, Flavell RA, Tilly JL, Rueda BR. Prostaglandin F2alpha- and FAS-activating antibody-induced regression of the corpus luteum involves caspase-8 and is defective in caspase-3 deficient mice. Reproductive Biology and Endocrinology : Rb&E. 1: 15. PMID 12657159 DOI: 10.1186/1477-7827-1-15  0.305
2003 Morse D, Otterbein LE, Watkins S, Alber S, Zhou Z, Flavell RA, Davis RJ, Choi AM. Deficiency in the c-Jun NH2-terminal kinase signaling pathway confers susceptibility to hyperoxic lung injury in mice. American Journal of Physiology. Lung Cellular and Molecular Physiology. 285: L250-7. PMID 12651633 DOI: 10.1152/Ajplung.00387.2002  0.325
2003 Blander JM, Sant'Angelo DB, Metz D, Kim SW, Flavell RA, Bottomly K, Janeway CA. A pool of central memory-like CD4 T cells contains effector memory precursors. Journal of Immunology (Baltimore, Md. : 1950). 170: 2940-8. PMID 12626545 DOI: 10.4049/Jimmunol.170.6.2940  0.523
2003 Zhang X, Shan P, Sasidhar M, Chupp GL, Flavell RA, Choi AM, Lee PJ. Reactive oxygen species and extracellular signal-regulated kinase 1/2 mitogen-activated protein kinase mediate hyperoxia-induced cell death in lung epithelium. American Journal of Respiratory Cell and Molecular Biology. 28: 305-15. PMID 12594056 DOI: 10.1165/Rcmb.2002-0156Oc  0.306
2003 Welte T, Zhang SS, Wang T, Zhang Z, Hesslein DG, Yin Z, Kano A, Iwamoto Y, Li E, Craft JE, Bothwell AL, Fikrig E, Koni PA, Flavell RA, Fu XY. STAT3 deletion during hematopoiesis causes Crohn's disease-like pathogenesis and lethality: a critical role of STAT3 in innate immunity. Proceedings of the National Academy of Sciences of the United States of America. 100: 1879-84. PMID 12571365 DOI: 10.1073/Pnas.0237137100  0.393
2003 Savinov AY, Tcherepanov A, Green EA, Flavell RA, Chervonsky AV. Contribution of Fas to diabetes development. Proceedings of the National Academy of Sciences of the United States of America. 100: 628-32. PMID 12525697 DOI: 10.1073/Pnas.0237359100  0.312
2003 Takai Y, Canning J, Perez GI, Pru JK, Schlezinger JJ, Sherr DH, Kolesnick RN, Yuan J, Flavell RA, Korsmeyer SJ, Tilly JL. Bax, caspase-2, and caspase-3 are required for ovarian follicle loss caused by 4-vinylcyclohexene diepoxide exposure of female mice in vivo Endocrinology. 144: 69-74. PMID 12488331 DOI: 10.1210/En.2002-220814  0.314
2002 Kontoyiannis D, Boulougouris G, Manoloukos M, Armaka M, Apostolaki M, Pizarro T, Kotlyarov A, Forster I, Flavell R, Gaestel M, Tsichlis P, Cominelli F, Kollias G. Genetic dissection of the cellular pathways and signaling mechanisms in modeled tumor necrosis factor-induced Crohn's-like inflammatory bowel disease. The Journal of Experimental Medicine. 196: 1563-74. PMID 12486099 DOI: 10.1084/Jem.20020281  0.353
2002 Horng T, Barton GM, Flavell RA, Medzhitov R. The adaptor molecule TIRAP provides signalling specificity for Toll-like receptors. Nature. 420: 329-33. PMID 12447442 DOI: 10.1038/Nature01180  0.343
2002 Le DA, Wu Y, Huang Z, Matsushita K, Plesnila N, Augustinack JC, Hyman BT, Yuan J, Kuida K, Flavell RA, Moskowitz MA. Caspase activation and neuroprotection in caspase-3- deficient mice after in vivo cerebral ischemia and in vitro oxygen glucose deprivation. Proceedings of the National Academy of Sciences of the United States of America. 99: 15188-93. PMID 12415117 DOI: 10.1073/Pnas.232473399  0.327
2002 Tan J, Town T, Crawford F, Mori T, DelleDonne A, Crescentini R, Obregon D, Flavell RA, Mullan MJ. Role of CD40 ligand in amyloidosis in transgenic Alzheimer's mice. Nature Neuroscience. 5: 1288-93. PMID 12402041 DOI: 10.1038/Nn968  0.647
2002 Whittaker L, Niu N, Temann UA, Stoddard A, Flavell RA, Ray A, Homer RJ, Cohn L. Interleukin-13 mediates a fundamental pathway for airway epithelial mucus induced by CD4 T cells and interleukin-9. American Journal of Respiratory Cell and Molecular Biology. 27: 593-602. PMID 12397019 DOI: 10.1165/Rcmb.4838  0.382
2002 Grewal IS, Grewal KD, Wong FS, Wang H, Picarella DE, Janeway CA, Flavell RA. Expression of transgene encoded TGF-beta in islets prevents autoimmune diabetes in NOD mice by a local mechanism. Journal of Autoimmunity. 19: 9-22. PMID 12367555 DOI: 10.1006/Jaut.2002.0599  0.322
2002 Hess P, Pihan G, Sawyers CL, Flavell RA, Davis RJ. Survival signaling mediated by c-Jun NH(2)-terminal kinase in transformed B lymphoblasts. Nature Genetics. 32: 201-5. PMID 12161751 DOI: 10.1038/Ng946  0.347
2002 Leonard JR, Klocke BJ, D'Sa C, Flavell RA, Roth KA. Strain-dependent neurodevelopmental abnormalities in caspase-3-deficient mice. Journal of Neuropathology and Experimental Neurology. 61: 673-7. PMID 12152782 DOI: 10.1093/Jnen/61.8.673  0.317
2002 Tanaka N, Kamanaka M, Enslen H, Dong C, Wysk M, Davis RJ, Flavell RA. Differential involvement of p38 mitogen-activated protein kinase kinases MKK3 and MKK6 in T-cell apoptosis. Embo Reports. 3: 785-91. PMID 12151339 DOI: 10.1093/Embo-Reports/Kvf153  0.405
2002 Kobayashi K, Hernandez LD, Galán JE, Janeway CA, Medzhitov R, Flavell RA. IRAK-M is a negative regulator of Toll-like receptor signaling. Cell. 110: 191-202. PMID 12150927 DOI: 10.1016/S0092-8674(02)00827-9  0.317
2002 Fields PE, Kim ST, Flavell RA. Cutting edge: changes in histone acetylation at the IL-4 and IFN-gamma loci accompany Th1/Th2 differentiation. Journal of Immunology (Baltimore, Md. : 1950). 169: 647-50. PMID 12097365 DOI: 10.4049/Jimmunol.169.2.647  0.597
2002 Alexopoulou L, Thomas V, Schnare M, Lobet Y, Anguita J, Schoen RT, Medzhitov R, Fikrig E, Flavell RA. Hyporesponsiveness to vaccination with Borrelia burgdorferi OspA in humans and in TLR1- and TLR2-deficient mice. Nature Medicine. 8: 878-84. PMID 12091878 DOI: 10.1038/Nm732  0.308
2002 Anguita J, Barthold SW, Persinski R, Hedrick MN, Huy CA, Davis RJ, Flavell RA, Fikrig E. Murine Lyme arthritis development mediated by p38 mitogen-activated protein kinase activity. Journal of Immunology (Baltimore, Md. : 1950). 168: 6352-7. PMID 12055252 DOI: 10.4049/Jimmunol.168.12.6352  0.341
2002 Gorelik L, Constant S, Flavell RA. Mechanism of transforming growth factor beta-induced inhibition of T helper type 1 differentiation. The Journal of Experimental Medicine. 195: 1499-505. PMID 12045248 DOI: 10.1084/Jem.20012076  0.335
2002 Oldstone MB, Race R, Thomas D, Lewicki H, Homann D, Smelt S, Holz A, Koni P, Lo D, Chesebro B, Flavell R. Lymphotoxin-alpha- and lymphotoxin-beta-deficient mice differ in susceptibility to scrapie: evidence against dendritic cell involvement in neuroinvasion. Journal of Virology. 76: 4357-63. PMID 11932402 DOI: 10.1128/Jvi.76.9.4357-4363.2002  0.313
2002 Conze D, Krahl T, Kennedy N, Weiss L, Lumsden J, Hess P, Flavell RA, Le Gros G, Davis RJ, Rincón M. c-Jun NH(2)-terminal kinase (JNK)1 and JNK2 have distinct roles in CD8(+) T cell activation. The Journal of Experimental Medicine. 195: 811-23. PMID 11927626 DOI: 10.1084/Jem.20011508  0.392
2002 Arbour N, Naniche D, Homann D, Davis RJ, Flavell RA, Oldstone MB. c-Jun NH(2)-terminal kinase (JNK)1 and JNK2 signaling pathways have divergent roles in CD8(+) T cell-mediated antiviral immunity. The Journal of Experimental Medicine. 195: 801-10. PMID 11927625 DOI: 10.1084/Jem.20011481  0.406
2002 Flavell RA, Dong C, Davis RJ. Signaling and cell death in lymphocytes. Inflammation Research : Official Journal of the European Histamine Research Society ... [Et Al.]. 51: 80-2. PMID 11926317 DOI: 10.1007/Bf02684006  0.406
2002 Kobayashi K, Inohara N, Hernandez LD, Galán JE, Núñez G, Janeway CA, Medzhitov R, Flavell RA. RICK/Rip2/CARDIAK mediates signalling for receptors of the innate and adaptive immune systems. Nature. 416: 194-9. PMID 11894098 DOI: 10.1038/416194A  0.377
2002 Koedel U, Winkler F, Angele B, Fontana A, Flavell RA, Pfister HW. Role of Caspase-1 in experimental pneumococcal meningitis: Evidence from pharmacologic Caspase inhibition and Caspase-1-deficient mice. Annals of Neurology. 51: 319-29. PMID 11891827 DOI: 10.1002/Ana.10103  0.31
2002 Green EA, Choi Y, Flavell RA. Pancreatic lymph node-derived CD4(+)CD25(+) Treg cells: highly potent regulators of diabetes that require TRANCE-RANK signals. Immunity. 16: 183-91. PMID 11869680 DOI: 10.1016/S1074-7613(02)00279-0  0.335
2002 Tan J, Town T, Mori T, Obregon D, Wu Y, DelleDonne A, Rojiani A, Crawford F, Flavell RA, Mullan M. CD40 is expressed and functional on neuronal cells. The Embo Journal. 21: 643-52. PMID 11847112 DOI: 10.1093/Emboj/21.4.643  0.662
2002 Topilski I, Harmelin A, Flavell RA, Levo Y, Shachar I. Preferential Th1 immune response in invariant chain-deficient mice. Journal of Immunology (Baltimore, Md. : 1950). 168: 1610-7. PMID 11823488 DOI: 10.4049/Jimmunol.168.4.1610  0.349
2002 Li X, Bu X, Lu B, Avraham H, Flavell RA, Lim B. The hematopoiesis-specific GTP-binding protein RhoH is GTPase deficient and modulates activities of other Rho GTPases by an inhibitory function. Molecular and Cellular Biology. 22: 1158-71. PMID 11809807 DOI: 10.1128/Mcb.22.4.1158-1171.2002  0.368
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