Year |
Citation |
Score |
2024 |
Kim J, Tadros B, Liang YH, Kim Y, Lasagna-Reeves C, Sonn JY, Chung DC, Hyman B, Holtzman DM, Zoghbi HY. TYK2 regulates tau levels, phosphorylation and aggregation in a tauopathy mouse model. Nature Neuroscience. PMID 39528671 DOI: 10.1038/s41593-024-01777-2 |
0.616 |
|
2024 |
Ganegamage SK, Ademoye TA, Patel H, Alnakhala H, Tripathi A, Nguyen CCD, Pham K, Plascencia-Villa G, Zhu X, Perry G, Tian S, Dettmer U, Lasagna-Reeves C, Fortin JS. Evaluation of Alpha-Synuclein and Tau Antiaggregation Activity of Urea and Thiourea-Based Small Molecules for Neurodegenerative Disease Therapeutics. Acs Chemical Neuroscience. PMID 39436010 DOI: 10.1021/acschemneuro.4c00282 |
0.416 |
|
2024 |
Martinez P, Jury-Garfe N, Patel H, You Y, Perkins A, You Y, Lee-Gosselin A, Vidal R, Lasagna-Reeves CA. Phosphorylation at serine 214 correlates with tau seeding activity in an age-dependent manner in two mouse models for tauopathies and is required for tau transsynaptic propagation. Biorxiv : the Preprint Server For Biology. PMID 39211286 DOI: 10.1101/2024.07.22.604618 |
0.45 |
|
2024 |
Jury-Garfe N, Redding-Ochoa J, You Y, Martínez P, Karahan H, Chimal-Juárez E, Johnson TS, Zhang J, Resnick S, Kim J, Troncoso JC, Lasagna-Reeves CA. Enhanced microglial dynamics and a paucity of tau seeding in the amyloid plaque microenvironment contribute to cognitive resilience in Alzheimer's disease. Acta Neuropathologica. 148: 15. PMID 39102080 DOI: 10.1007/s00401-024-02775-1 |
0.455 |
|
2024 |
Martinez P, Patel H, You Y, Doud EH, Mosley AL, Lasagna-Reeves CA. Protocol for the isolation and proteomic analysis of pathological tau-seeds. Star Protocols. 5: 103185. PMID 39078738 DOI: 10.1016/j.xpro.2024.103185 |
0.325 |
|
2024 |
Codocedo JF, Mera-Reina C, Bor-Chian Lin P, Fallen PB, Puntambekar SS, Casali BT, Jury-Garfe N, Martinez P, Lasagna-Reeves CA, Landreth GE. Therapeutic targeting of immunometabolism reveals a critical reliance on hexokinase 2 dosage for microglial activation and Alzheimer's progression. Cell Reports. 43: 114488. PMID 39002124 DOI: 10.1016/j.celrep.2024.114488 |
0.345 |
|
2024 |
Dabin LC, Kersey H, Kim B, Acri DJ, Sharify D, Lee-Gosselin A, Lasagna-Reeves CA, Oblak AL, Lamb BT, Kim J. Loss of Inpp5d has disease-relevant and sex-specific effects on glial transcriptomes. Alzheimer's & Dementia : the Journal of the Alzheimer's Association. PMID 38923164 DOI: 10.1002/alz.13901 |
0.346 |
|
2023 |
Codocedo JF, Mera-Reina C, Lin PB, Puntambekar SS, Casali BT, Jury N, Martinez P, Lasagna-Reeves CA, Landreth GE. Therapeutic targeting of immunometabolism in Alzheimer's disease reveals a critical reliance on Hexokinase 2 dosage on microglial activation and disease progression. Biorxiv : the Preprint Server For Biology. PMID 38014106 DOI: 10.1101/2023.11.11.566270 |
0.368 |
|
2023 |
Ramirez E, Ganegamage SK, Min S, Patel H, Ogunware A, Plascencia-Villa G, Alnakhala H, Shimanaka K, Tripathi A, Wang KW, Zhu X, Rochet JC, Kuo MH, Counts SE, Perry G, ... ... Lasagna-Reeves CA, et al. Evaluation of N- and O-Linked Indole Triazines for a Dual Effect on α-Synuclein and Tau Aggregation. Acs Chemical Neuroscience. PMID 37818657 DOI: 10.1021/acschemneuro.3c00464 |
0.437 |
|
2023 |
Acri DJ, You Y, Tate MD, Karahan H, Martinez P, McCord B, Sharify AD, John S, Kim B, Dabin LC, Philtjens S, Wijeratne HRS, McCray TJ, Smith DC, Bissel SJ, ... ... Lasagna-Reeves CA, et al. Network analysis identifies strain-dependent response to tau and tau seeding-associated genes. The Journal of Experimental Medicine. 220. PMID 37606887 DOI: 10.1084/jem.20230180 |
0.421 |
|
2023 |
Jury-Garfe N, You Y, Martínez P, Redding-Ochoa J, Karahan H, Johnson TS, Zhang J, Kim J, Troncoso JC, Lasagna-Reeves CA. Enhanced microglial dynamics and paucity of tau seeding in the amyloid plaque microenvironment contributes to cognitive resilience in Alzheimer's disease. Biorxiv : the Preprint Server For Biology. PMID 37546928 DOI: 10.1101/2023.07.27.550884 |
0.462 |
|
2023 |
Lee-Gosselin A, Jury-Garfe N, You Y, Dabin L, Soni D, Dutta S, Rochet JC, Kim J, Oblak AL, Lasagna-Reeves CA. TREM2-Deficient Microglia Attenuate Tau Spreading In Vivo. Cells. 12. PMID 37371067 DOI: 10.3390/cells12121597 |
0.496 |
|
2023 |
Moutinho M, Coronel I, Tsai AP, Di Prisco GV, Pennington T, Atwood BK, Puntambekar SS, Smith DC, Martinez P, Han S, Lee Y, Lasagna-Reeves CA, Lamb BT, Bissel SJ, Nho K, et al. TREM2 splice isoforms generate soluble TREM2 species that disrupt long-term potentiation. Genome Medicine. 15: 11. PMID 36805764 DOI: 10.1186/s13073-023-01160-z |
0.358 |
|
2023 |
Acri DJ, You Y, Tate MD, McCord B, Sharify AD, John S, Karahan H, Kim B, Dabin LC, Philtjens S, Wijeratne HRS, McCray TJ, Smith DC, Bissel SJ, Lamb BT, ... Lasagna-Reeves CA, et al. Network analysis reveals strain-dependent response to misfolded tau aggregates. Biorxiv : the Preprint Server For Biology. PMID 36778440 DOI: 10.1101/2023.01.28.526029 |
0.41 |
|
2022 |
Martinez P, Patel H, You Y, Jury N, Perkins A, Lee-Gosselin A, Taylor X, You Y, Viana Di Prisco G, Huang X, Dutta S, Wijeratne AB, Redding-Ochoa J, Shahid SS, Codocedo JF, ... ... Lasagna-Reeves CA, et al. Bassoon contributes to tau-seed propagation and neurotoxicity. Nature Neuroscience. PMID 36344699 DOI: 10.1038/s41593-022-01191-6 |
0.835 |
|
2022 |
Cisternas P, Taylor X, Martinez P, Maldonado O, Jury N, Lasagna-Reeves CA. The reduction of astrocytic tau prevents amyloid-β-induced synaptotoxicity. Brain Communications. 4: fcac235. PMID 36196088 DOI: 10.1093/braincomms/fcac235 |
0.808 |
|
2022 |
Puntambekar SS, Moutinho M, Lin PB, Jadhav V, Tumbleson-Brink D, Balaji A, Benito MA, Xu G, Oblak A, Lasagna-Reeves CA, Landreth GE, Lamb BT. CX3CR1 deficiency aggravates amyloid driven neuronal pathology and cognitive decline in Alzheimer's disease. Molecular Neurodegeneration. 17: 47. PMID 35764973 DOI: 10.1186/s13024-022-00545-9 |
0.414 |
|
2022 |
Taylor X, Cisternas P, Jury N, Martinez P, Huang X, You Y, Redding-Ochoa J, Vidal R, Zhang J, Troncoso J, Lasagna-Reeves CA. Activated endothelial cells induce a distinct type of astrocytic reactivity. Communications Biology. 5: 282. PMID 35351973 DOI: 10.1038/s42003-022-03237-8 |
0.764 |
|
2022 |
Moutinho M, Puntambekar SS, Tsai AP, Coronel I, Lin PB, Casali BT, Martinez P, Oblak AL, Lasagna-Reeves CA, Lamb BT, Landreth GE. The niacin receptor HCAR2 modulates microglial response and limits disease progression in a mouse model of Alzheimer's disease. Science Translational Medicine. 14: eabl7634. PMID 35320002 DOI: 10.1126/scitranslmed.abl7634 |
0.435 |
|
2021 |
Patel H, Martinez P, Perkins A, Taylor X, Jury N, McKinzie D, Lasagna-Reeves CA. Pathological tau and reactive astrogliosis are associated with distinct functional deficits in a mouse model of tauopathy. Neurobiology of Aging. 109: 52-63. PMID 34655981 DOI: 10.1016/j.neurobiolaging.2021.09.006 |
0.818 |
|
2020 |
Cisternas P, Taylor X, Perkins A, Maldonado O, Allman E, Cordova R, Marambio Y, Munoz B, Pennington T, Xiang S, Zhang J, Vidal R, Atwood B, Lasagna-Reeves CA. Vascular amyloid accumulation alters the gabaergic synapse and induces hyperactivity in a model of cerebral amyloid angiopathy. Aging Cell. e13233. PMID 32914559 DOI: 10.1111/Acel.13233 |
0.81 |
|
2020 |
Taylor X, Cisternas P, You Y, You Y, Xiang S, Marambio Y, Zhang J, Vidal R, Lasagna-Reeves CA. A1 reactive astrocytes and a loss of TREM2 are associated with an early stage of pathology in a mouse model of cerebral amyloid angiopathy. Journal of Neuroinflammation. 17: 223. PMID 32711525 DOI: 10.1186/S12974-020-01900-7 |
0.812 |
|
2019 |
You Y, Perkins A, Cisternas P, Muñoz B, Taylor X, You Y, Garringer HJ, Oblak AL, Atwood BK, Vidal R, Lasagna-Reeves CA. Tau as a mediator of neurotoxicity associated to cerebral amyloid angiopathy. Acta Neuropathologica Communications. 7: 26. PMID 30808415 DOI: 10.1186/S40478-019-0680-Z |
0.828 |
|
2017 |
Bemiller SM, McCray TJ, Allan K, Formica SV, Xu G, Wilson G, Kokiko-Cochran ON, Crish SD, Lasagna-Reeves CA, Ransohoff RM, Landreth GE, Lamb BT. TREM2 deficiency exacerbates tau pathology through dysregulated kinase signaling in a mouse model of tauopathy. Molecular Neurodegeneration. 12: 74. PMID 29037207 DOI: 10.1186/S13024-017-0216-6 |
0.547 |
|
2016 |
Rousseaux MW, de Haro M, Lasagna-Reeves CA, De Maio A, Park J, Jafar-Nejad P, Al-Ramahi I, Sharma A, See L, Lu N, Vilanova-Velez L, Klisch TJ, Westbrook TF, Troncoso JC, Botas J, et al. TRIM28 regulates the nuclear accumulation and toxicity of both alpha-synuclein and tau. Elife. 5. PMID 27779468 DOI: 10.7554/Elife.19809 |
0.798 |
|
2016 |
Lasagna-Reeves CA, de Haro M, Hao S, Park J, Rousseaux MW, Al-Ramahi I, Jafar-Nejad P, Vilanova-Velez L, See L, De Maio A, Nitschke L, Wu Z, Troncoso JC, Westbrook TF, Tang J, et al. Reduction of Nuak1 Decreases Tau and Reverses Phenotypes in a Tauopathy Mouse Model. Neuron. PMID 27720485 DOI: 10.1016/J.Neuron.2016.09.022 |
0.816 |
|
2016 |
Rousseaux MW, Haro Md, Lasagna-Reeves CA, Maio AD, Park J, Jafar-Nejad P, Al-Ramahi I, Sharma A, See L, Lu N, Vilanova-Velez L, Klisch TJ, Westbrook TF, Troncoso JC, Botas J, et al. Author response: TRIM28 regulates the nuclear accumulation and toxicity of both alpha-synuclein and tau Elife. DOI: 10.7554/Elife.19809.028 |
0.784 |
|
2015 |
Lasagna-Reeves CA, Rousseaux MW, Guerrero-Munoz MJ, Vilanova-Velez L, Park J, See L, Jafar-Nejad P, Richman R, Orr HT, Kayed R, Zoghbi HY. Ataxin-1 oligomers induce local spread of pathology and decreasing them by passive immunization slows Spinocerebellar ataxia type 1 phenotypes. Elife. 4. PMID 26673892 DOI: 10.7554/Elife.10891 |
0.765 |
|
2015 |
Lasagna-Reeves CA, Rousseaux MW, Guerrero-Muñoz MJ, Park J, Jafar-Nejad P, Richman R, Lu N, Sengupta U, Litvinchuk A, Orr HT, Kayed R, Zoghbi HY. A native interactor scaffolds and stabilizes toxic ATAXIN-1 oligomers in SCA1. Elife. 4. PMID 25988806 DOI: 10.7554/Elife.07558 |
0.799 |
|
2015 |
Sengupta U, Guerrero-Muñoz MJ, Castillo-Carranza DL, Lasagna-Reeves CA, Gerson JE, Paulucci-Holthauzen AA, Krishnamurthy S, Farhed M, Jackson GR, Kayed R. Pathological Interface between Oligomeric Alpha-Synuclein and Tau in Synucleinopathies. Biological Psychiatry. PMID 25676491 DOI: 10.1016/J.Biopsych.2014.12.019 |
0.647 |
|
2015 |
Lasagna-Reeves CA, Rousseaux MW, Guerrero-Munoz MJ, Vilanova-Velez L, Park J, See L, Jafar-Nejad P, Richman R, Orr HT, Kayed R, Zoghbi HY. Author response: Ataxin-1 oligomers induce local spread of pathology and decreasing them by passive immunization slows Spinocerebellar ataxia type 1 phenotypes Elife. DOI: 10.7554/Elife.10891.010 |
0.753 |
|
2015 |
Lasagna-Reeves CA, Rousseaux MW, Guerrero-Muñoz MJ, Park J, Jafar-Nejad P, Richman R, Lu N, Sengupta U, Litvinchuk A, Orr HT, Kayed R, Zoghbi HY. Author response: A native interactor scaffolds and stabilizes toxic ATAXIN-1 oligomers in SCA1 Elife. DOI: 10.7554/Elife.07558.025 |
0.759 |
|
2015 |
Lasagna-Reeves CA, Rousseaux MWC, Guerrero-Munoz MJ, Park J, Jafar-Nejad P, Richman R, Lu N, Sengupta U, Litvinchuk A, Orr HT, Kayed R, Zoghbi HY. A native interactor scaffolds and stabilizes toxic Ataxin-1 oligomers in SCA1 Elife. 4: 1-46. DOI: 10.7554/eLife.07558 |
0.78 |
|
2015 |
Rousseaux M, de Haro M, Lasagna-Reeves C, De Maio A, Jafar-Nejad P, Park J, Al-Ramahi I, Kayed R, Botas H, Zoghbi H. TRIM28 regulates the stability and toxicity of alpha-synuclein and tau through a common mechanism Journal of the Neurological Sciences. 357: e285-e286. DOI: 10.1016/J.Jns.2015.08.996 |
0.783 |
|
2015 |
Lasagna-Reeves C, Al Ramahi I, de Haro M, Rousseaux M, Kim J, Jafar-Nejad P, Vilanova-Velez L, Westbrook T, Botas J, Zoghbi H. Targeting tau protein stability in alzheimer disease to identify novel therapeutic entry points Journal of the Neurological Sciences. 357: e131. DOI: 10.1016/J.Jns.2015.08.422 |
0.813 |
|
2014 |
Guerrero-Muñoz MJ, Castillo-Carranza DL, Krishnamurthy S, Paulucci-Holthauzen AA, Sengupta U, Lasagna-Reeves CA, Ahmad Y, Jackson GR, Kayed R. Amyloid-β oligomers as a template for secondary amyloidosis in Alzheimer's disease. Neurobiology of Disease. 71: 14-23. PMID 25134727 DOI: 10.1016/J.Nbd.2014.08.008 |
0.684 |
|
2014 |
Gerson JE, Sengupta U, Lasagna-Reeves CA, Guerrero-Muñoz MJ, Troncoso J, Kayed R. Characterization of tau oligomeric seeds in progressive supranuclear palsy. Acta Neuropathologica Communications. 2: 73. PMID 24927818 DOI: 10.1186/2051-5960-2-73 |
0.701 |
|
2014 |
Lasagna-Reeves CA, Sengupta U, Castillo-Carranza D, Gerson JE, Guerrero-Munoz M, Troncoso JC, Jackson GR, Kayed R. The formation of tau pore-like structures is prevalent and cell specific: possible implications for the disease phenotypes. Acta Neuropathologica Communications. 2: 56. PMID 24887264 DOI: 10.1186/2051-5960-2-56 |
0.731 |
|
2014 |
Castillo-Carranza DL, Sengupta U, Guerrero-Muñoz MJ, Lasagna-Reeves CA, Gerson JE, Singh G, Estes DM, Barrett AD, Dineley KT, Jackson GR, Kayed R. Passive immunization with Tau oligomer monoclonal antibody reverses tauopathy phenotypes without affecting hyperphosphorylated neurofibrillary tangles. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 34: 4260-72. PMID 24647946 DOI: 10.1523/Jneurosci.3192-13.2014 |
0.704 |
|
2014 |
Castillo-Carranza DL, Gerson JE, Sengupta U, Guerrero-Muñoz MJ, Lasagna-Reeves CA, Kayed R. Specific targeting of tau oligomers in Htau mice prevents cognitive impairment and tau toxicity following injection with brain-derived tau oligomeric seeds. Journal of Alzheimer's Disease : Jad. 40: S97-S111. PMID 24603946 DOI: 10.3233/Jad-132477 |
0.71 |
|
2013 |
Castillo-Carranza DL, Lasagna-Reeves CA, Kayed R. Tau aggregates as immunotherapeutic targets. Frontiers in Bioscience (Scholar Edition). 5: 426-38. PMID 23277060 DOI: 10.2741/S381 |
0.727 |
|
2013 |
Lasagna-Reeves CA, Clos AL, Castillo-Carranza D, Sengupta U, Guerrero-Muñoz M, Kelly B, Wagner R, Kayed R. Dual role of p53 amyloid formation in cancer; loss of function and gain of toxicity. Biochemical and Biophysical Research Communications. 430: 963-8. PMID 23261448 DOI: 10.1016/J.Bbrc.2012.11.130 |
0.621 |
|
2013 |
Kayed R, Lasagna-Reeves CA. Molecular mechanisms of amyloid oligomers toxicity. Journal of Alzheimer's Disease : Jad. 33: S67-78. PMID 22531422 DOI: 10.3233/Jad-2012-129001 |
0.678 |
|
2013 |
Guerrero-Munoz M, Castillo-Carranza D, Lasagna-Reeves C, Sengupta U, Krishnamurthy S, Jackson G, Kayed R. P1-403: Formation of toxic oligomeric species from different proteins in Alzheimer's disease: Potential toxic interactions at the oligomer aggregation stage Alzheimer's & Dementia. 9: P305-P305. DOI: 10.1016/J.Jalz.2013.05.631 |
0.631 |
|
2012 |
Lasagna-Reeves CA, Castillo-Carranza DL, Sengupta U, Guerrero-Munoz MJ, Kiritoshi T, Neugebauer V, Jackson GR, Kayed R. Alzheimer brain-derived tau oligomers propagate pathology from endogenous tau. Scientific Reports. 2: 700. PMID 23050084 DOI: 10.1038/Srep00700 |
0.693 |
|
2012 |
Clos AL, Kayed R, Lasagna-Reeves CA. Association of skin with the pathogenesis and treatment of neurodegenerative amyloidosis. Frontiers in Neurology. 3: 5. PMID 22319507 DOI: 10.3389/Fneur.2012.00005 |
0.631 |
|
2012 |
Lasagna-Reeves CA, Castillo-Carranza DL, Sengupta U, Sarmiento J, Troncoso J, Jackson GR, Kayed R. Identification of oligomers at early stages of tau aggregation in Alzheimer's disease. Faseb Journal : Official Publication of the Federation of American Societies For Experimental Biology. 26: 1946-59. PMID 22253473 DOI: 10.1096/Fj.11-199851 |
0.717 |
|
2012 |
Castillo-Carranza D, Lasagna-Reeves C, Guerrero-Munoz M, Sengupta U, Barrett A, Dineley K, Jackson G, Kayed R. O4-06-01: Specific clearance of tau oligomers by passive immunization Alzheimer's & Dementia. 8: P624-P625. DOI: 10.1016/J.Jalz.2012.05.1664 |
0.572 |
|
2011 |
Lasagna-Reeves CA, Kayed R. Astrocytes contain amyloid-β annular protofibrils in Alzheimer's disease brains. Febs Letters. 585: 3052-7. PMID 21872592 DOI: 10.1016/J.Febslet.2011.08.027 |
0.671 |
|
2011 |
Clos AL, Lasagna-Reeves CA, Castillo-Carranza DL, Sengupta U, Jackson GR, Kelly B, Beachkofsky TM, Kayed R. Formation of immunoglobulin light chain amyloid oligomers in primary cutaneous nodular amyloidosis. The British Journal of Dermatology. 165: 1349-54. PMID 21729025 DOI: 10.1111/J.1365-2133.2011.10508.X |
0.656 |
|
2011 |
Clos AL, Lasagna-Reeves CA, Kelly B, Wagner R, Wilkerson M, Jackson GR, Kayed R. Role of oligomers in the amyloidogenesis of primary cutaneous amyloidosis. Journal of the American Academy of Dermatology. 65: 1023-31. PMID 21669474 DOI: 10.1016/J.Jaad.2010.09.735 |
0.653 |
|
2011 |
Lasagna-Reeves CA, Castillo-Carranza DL, Sengupta U, Clos AL, Jackson GR, Kayed R. Tau oligomers impair memory and induce synaptic and mitochondrial dysfunction in wild-type mice. Molecular Neurodegeneration. 6: 39. PMID 21645391 DOI: 10.1186/1750-1326-6-39 |
0.708 |
|
2011 |
Lasagna-Reeves CA, Castillo-Carranza DL, Jackson GR, Kayed R. Tau oligomers as potential targets for immunotherapy for Alzheimer's disease and tauopathies. Current Alzheimer Research. 8: 659-65. PMID 21605039 DOI: 10.2174/156720511796717177 |
0.719 |
|
2011 |
Lasagna-Reeves CA, Glabe CG, Kayed R. Amyloid-β annular protofibrils evade fibrillar fate in Alzheimer disease brain. The Journal of Biological Chemistry. 286: 22122-30. PMID 21507938 DOI: 10.1074/Jbc.M111.236257 |
0.695 |
|
2010 |
Lasagna-Reeves CA, Castillo-Carranza DL, Guerrero-Muoz MJ, Jackson GR, Kayed R. Preparation and characterization of neurotoxic tau oligomers. Biochemistry. 49: 10039-41. PMID 21047142 DOI: 10.1021/Bi1016233 |
0.719 |
|
2010 |
Lasagna-Reeves CA, Clos AL, Midoro-Hiriuti T, Goldblum RM, Jackson GR, Kayed R. Inhaled insulin forms toxic pulmonary amyloid aggregates. Endocrinology. 151: 4717-24. PMID 20685871 DOI: 10.1210/En.2010-0457 |
0.578 |
|
2010 |
Clos AL, Lasagna-Reeves CA, Wagner R, Kelly B, Jackson GR, Kayed R. Therapeutic removal of amyloid deposits in cutaneous amyloidosis by localised intra-lesional injections of anti-amyloid antibodies. Experimental Dermatology. 19: 904-11. PMID 20626464 DOI: 10.1111/J.1600-0625.2010.01121.X |
0.607 |
|
2009 |
Mina EW, Lasagna-Reeves C, Glabe CG, Kayed R. Poloxamer 188 copolymer membrane sealant rescues toxicity of amyloid oligomers in vitro. Journal of Molecular Biology. 391: 577-85. PMID 19524592 DOI: 10.1016/J.Jmb.2009.06.024 |
0.607 |
|
2008 |
Martin-Jones Z, Lasagna-Reeves C. Which is a better target for AD immunotherapy, A beta or tau? Alzheimer Disease and Associated Disorders. 22: 111-2. PMID 18525281 DOI: 10.1097/Wad.0B013E3181641355 |
0.409 |
|
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