| Year |
Citation |
Score |
| 2023 |
Shi DD, Lee JH, Wang AC, Khanal J, Gao W, Kaelin WG, McBrayer SK. Protocol to establish a genetically engineered mouse model of IDH1-mutant astrocytoma. Star Protocols. 4: 102281. PMID 37149859 DOI: 10.1016/j.xpro.2023.102281 |
0.257 |
|
| 2022 |
Miller JJ, Gonzalez Castro LN, McBrayer S, Weller M, Cloughesy T, Portnow J, Andronesi O, Barnholtz-Sloan JS, Baumert BG, Berger MS, Bi WL, Bindra R, Cahill DP, Chang SM, Costello JF, ... ... Kaelin WG, et al. Isocitrate dehydrogenase (IDH) mutant gliomas: A Society for Neuro-Oncology (SNO) consensus review on diagnosis, management, and future directions. Neuro-Oncology. PMID 36239925 DOI: 10.1093/neuonc/noac207 |
0.272 |
|
| 2022 |
Kaelin WG. THE JEREMIAH METZGER LECTURE:VON HIPPEL-LINDAU DISEASE: INSIGHTS INTO OXYGEN SENSING, CANCER AND DRUGGING THE UNDRUGGABLE. Transactions of the American Clinical and Climatological Association. 132: 170-181. PMID 36196173 |
0.437 |
|
| 2022 |
Kaelin WG. Von Hippel-Lindau disease: insights into oxygen sensing, protein degradation, and cancer. The Journal of Clinical Investigation. 132. PMID 36106637 DOI: 10.1172/JCI162480 |
0.429 |
|
| 2022 |
Shi DD, Savani MR, Levitt MM, Wang AC, Endress JE, Bird CE, Buehler J, Stopka SA, Regan MS, Lin YF, Puliyappadamba VT, Gao W, Khanal J, Evans L, Lee JH, ... ... Kaelin WG, et al. De novo pyrimidine synthesis is a targetable vulnerability in IDH mutant glioma. Cancer Cell. PMID 35985343 DOI: 10.1016/j.ccell.2022.07.011 |
0.34 |
|
| 2022 |
Wyant GA, Yu W, Doulamis IP, Nomoto RS, Saeed MY, Duignan T, McCully JD, Kaelin WG. Mitochondrial remodeling and ischemic protection by G protein-coupled receptor 35 agonists. Science (New York, N.Y.). 377: 621-629. PMID 35926043 DOI: 10.1126/science.abm1638 |
0.259 |
|
| 2022 |
Grubb T, Maganti S, Krill-Burger JM, Fraser C, Stransky L, Radivoyevitch T, Sarosiek KA, Vazquez F, Kaelin WG, Chakraborty AA. A Mesenchymal Tumor Cell State Confers Increased Dependency on the BCL-XL Anti-apoptotic Protein in Kidney Cancer. Clinical Cancer Research : An Official Journal of the American Association For Cancer Research. PMID 35776130 DOI: 10.1158/1078-0432.CCR-22-0669 |
0.366 |
|
| 2022 |
Stransky LA, Vigeant SM, Huang B, West D, Denize T, Walton E, Signoretti S, Kaelin WG. Sensitivity of mutant kidney cancers to HIF2 inhibitors does not require an intact p53 pathway. Proceedings of the National Academy of Sciences of the United States of America. 119: e2120403119. PMID 35357972 DOI: 10.1073/pnas.2120403119 |
0.422 |
|
| 2021 |
Choueiri TK, Albiges L, Atkins MB, Bakouny Z, Bratslavsky G, Braun DA, Haas NB, Haanen JBAG, Hakimi AA, Jewett MAS, Jonasch E, Kaelin WG, Kapur P, Labaki C, Lewis B, et al. From Basic Science to Clinical Translation in Kidney Cancer: A Report from the Second Kidney Cancer Research Summit. Clinical Cancer Research : An Official Journal of the American Association For Cancer Research. PMID 34965942 DOI: 10.1158/1078-0432.CCR-21-3238 |
0.29 |
|
| 2021 |
Kaelin WG. David M. Livingston (1941-2021). Cell. 184: 6007-6009. PMID 34890547 DOI: 10.1016/j.cell.2021.11.006 |
0.165 |
|
| 2021 |
Kamihara J, Hamilton KV, Pollard JA, Clinton CM, Madden JA, Lin J, Imamovic A, Wall CB, Wassner AJ, Weil BR, Heeney MM, Vargas SO, Kaelin WG, Janeway KA, Perini RF, et al. Belzutifan, a Potent HIF2α Inhibitor, in the Pacak-Zhuang Syndrome. The New England Journal of Medicine. 385: 2059-2065. PMID 34818480 DOI: 10.1056/NEJMoa2110051 |
0.322 |
|
| 2021 |
Koduri V, Duplaquet L, Lampson BL, Wang AC, Sabet AH, Ishoey M, Paulk J, Teng M, Harris IS, Endress JE, Liu X, Dasilva E, Paulo JA, Briggs KJ, Doench JG, ... ... Kaelin WG, et al. Targeting oncoproteins with a positive selection assay for protein degraders. Science Advances. 7. PMID 33547076 DOI: 10.1126/sciadv.abd6263 |
0.753 |
|
| 2020 |
Losman JA, Koivunen P, Kaelin WG. 2-Oxoglutarate-dependent dioxygenases in cancer. Nature Reviews. Cancer. PMID 33087883 DOI: 10.1038/s41568-020-00303-3 |
0.397 |
|
| 2020 |
Choueiri TK, Kaelin WG. Targeting the HIF2-VEGF axis in renal cell carcinoma. Nature Medicine. 26: 1519-1530. PMID 33020645 DOI: 10.1038/s41591-020-1093-z |
0.394 |
|
| 2020 |
Liu J, Peng Y, Shi L, Wan L, Inuzuka H, Long J, Guo J, Zhang J, Yuan M, Zhang S, Wang X, Gao J, Dai X, Furumoto S, Jia L, ... ... Kaelin WG, et al. Author Correction: Skp2 dictates cell cycle-dependent metabolic oscillation between glycolysis and TCA cycle. Cell Research. PMID 32859994 DOI: 10.1038/S41422-020-00406-4 |
0.361 |
|
| 2020 |
Liu J, Peng Y, Shi L, Wan L, Inuzuka H, Long J, Guo J, Zhang J, Yuan M, Zhang S, Wang X, Gao J, Dai X, Furumoto S, Jia L, ... ... Kaelin WG, et al. Skp2 dictates cell cycle-dependent metabolic oscillation between glycolysis and TCA cycle. Cell Research. PMID 32669607 DOI: 10.1038/S41422-020-0372-Z |
0.422 |
|
| 2019 |
Zhang H, Christensen CL, Dries R, Oser MG, Deng J, Diskin B, Li F, Pan Y, Zhang X, Yin Y, Papadopoulos E, Pyon V, Thakurdin C, Kwiatkowski N, Jani K, ... ... Kaelin WG, et al. CDK7 Inhibition Potentiates Genome Instability Triggering Anti-tumor Immunity in Small Cell Lung Cancer. Cancer Cell. PMID 31883968 DOI: 10.1016/J.Ccell.2019.11.003 |
0.438 |
|
| 2019 |
Cable J, Finley L, Tu BP, Patti GJ, Oliver TG, Vardhana S, Mana M, Ericksen R, Khare S, DeBerardinis R, Stockwell BR, Edinger A, Haigis M, Kaelin W. Leveraging insights into cancer metabolism-a symposium report. Annals of the New York Academy of Sciences. PMID 31792987 DOI: 10.1111/Nyas.14274 |
0.433 |
|
| 2019 |
Oser MG, Sabet AH, Gao W, Chakraborty AA, Schinzel AC, Jennings RB, Fonseca R, Bonal DM, Booker MA, Flaifel A, Novak JS, Christensen CL, Zhang H, Herbert ZT, Tolstorukov MY, ... ... Kaelin WG, et al. The KDM5A/RBP2 histone demethylase represses NOTCH signaling to sustain neuroendocrine differentiation and promote small cell lung cancer tumorigenesis. Genes & Development. PMID 31727771 DOI: 10.1101/Gad.328336.119 |
0.493 |
|
| 2019 |
Nicholson HE, Tariq Z, Housden BE, Jennings RB, Stransky LA, Perrimon N, Signoretti S, Kaelin WG. HIF-independent synthetic lethality between CDK4/6 inhibition and VHL loss across species. Science Signaling. 12. PMID 31575731 DOI: 10.1126/Scisignal.Aay0482 |
0.424 |
|
| 2019 |
Sethi N, Kikuchi O, McFarland J, Zhang Y, Chung M, Kafker N, Islam M, Lampson B, Chakraborty A, Kaelin WG, Bass AJ. Mutant p53 induces a hypoxia transcriptional program in gastric and esophageal adenocarcinoma. Jci Insight. 4. PMID 31391338 DOI: 10.1172/Jci.Insight.128439 |
0.44 |
|
| 2019 |
Li S, Rodriguez J, Li W, Bullova P, Fell SM, Surova O, Westerlund I, Topcic D, Bergsland M, Stenman A, Muhr J, Nistér M, Holmberg J, Juhlin CC, Larsson C, ... ... Kaelin WG, et al. EglN3 hydroxylase stabilizes BIM-EL linking VHL type 2C mutations to pheochromocytoma pathogenesis and chemotherapy resistance. Proceedings of the National Academy of Sciences of the United States of America. PMID 31375625 DOI: 10.1073/Pnas.1900748116 |
0.486 |
|
| 2019 |
Chakraborty AA, Laukka T, Myllykoski M, Ringel AE, Booker MA, Tolstorukov MY, Meng YJ, Meier SR, Jennings RB, Creech AL, Herbert ZT, McBrayer SK, Olenchock BA, Jaffe JD, Haigis MC, ... ... Kaelin WG, et al. Histone demethylase KDM6A directly senses oxygen to control chromatin and cell fate. Science (New York, N.Y.). 363: 1217-1222. PMID 30872525 DOI: 10.1126/Science.Aaw1026 |
0.411 |
|
| 2019 |
Harris IS, Endress JE, Coloff JL, Selfors LM, McBrayer SK, Rosenbluth JM, Takahashi N, Dhakal S, Koduri V, Oser MG, Schauer NJ, Doherty LM, Hong AL, Kang YP, Younger ST, ... ... Kaelin WG, et al. Deubiquitinases Maintain Protein Homeostasis and Survival of Cancer Cells upon Glutathione Depletion. Cell Metabolism. PMID 30799286 DOI: 10.1016/J.Cmet.2019.01.020 |
0.461 |
|
| 2019 |
Koduri V, McBrayer SK, Liberzon E, Wang AC, Briggs KJ, Cho H, Kaelin WG. Peptidic degron for IMiD-induced degradation of heterologous proteins. Proceedings of the National Academy of Sciences of the United States of America. PMID 30683719 DOI: 10.1073/Pnas.1818109116 |
0.453 |
|
| 2019 |
Nicholson H, Housden B, Perrimon N, Kaelin WG. Abstract C124: HIF-independent synthetic lethality between CDK4/6 inhibition and VHL loss across species Molecular Cancer Therapeutics. 18. DOI: 10.1158/1535-7163.Targ-19-C124 |
0.529 |
|
| 2018 |
Oser MG, Fonseca R, Chakraborty AA, Brough R, Spektor A, Jennings RB, Flaifel A, Novak JS, Gulati A, Buss E, Younger ST, McBrayer SK, Cowley GS, Bonal DM, Nguyen QD, ... ... Kaelin WG, et al. Cells Lacking the RB1 Tumor Suppressor Gene are Hyperdependent on Aurora B Kinase for Survival. Cancer Discovery. PMID 30373918 DOI: 10.1158/2159-8290.Cd-18-0389 |
0.471 |
|
| 2018 |
Li AG, Murphy EC, Culhane AC, Powell E, Wang H, Bronson RT, Von T, Giobbie-Hurder A, Gelman RS, Briggs KJ, Piwnica-Worms H, Zhao JJ, Kung AL, Kaelin WG, Livingston DM. BRCA1-IRIS promotes human tumor progression through PTEN blockade and HIF-1α activation. Proceedings of the National Academy of Sciences of the United States of America. PMID 30254159 DOI: 10.1073/Pnas.1807112115 |
0.622 |
|
| 2018 |
McBrayer SK, Mayers JR, DiNatale GJ, Shi DD, Khanal J, Chakraborty AA, Sarosiek KA, Briggs KJ, Robbins AK, Sewastianik T, Shareef SJ, Olenchock BA, Parker SJ, Tateishi K, Spinelli JB, ... ... Kaelin WG, et al. Transaminase Inhibition by 2-Hydroxyglutarate Impairs Glutamate Biosynthesis and Redox Homeostasis in Glioma. Cell. PMID 30220459 DOI: 10.1016/J.Cell.2018.08.038 |
0.4 |
|
| 2018 |
Zhang J, Wu T, Simon J, Takada M, Saito R, Fan C, Liu XD, Jonasch E, Xie L, Chen X, Yao X, Teh BT, Tan P, Zheng X, Li M, ... ... Kaelin WG, et al. VHL substrate transcription factor ZHX2 as an oncogenic driver in clear cell renal cell carcinoma. Science (New York, N.Y.). 361: 290-295. PMID 30026228 DOI: 10.1126/Science.Aap8411 |
0.528 |
|
| 2018 |
McBrayer SK, Olenchock BA, DiNatale GJ, Shi DD, Khanal J, Jennings RB, Novak JS, Oser MG, Robbins AK, Modiste R, Bonal D, Moslehi J, Bronson RT, Neuberg D, Nguyen QD, ... ... Kaelin WG, et al. Autochthonous tumors driven byloss have an ongoing requirement for the RBP2 histone demethylase. Proceedings of the National Academy of Sciences of the United States of America. PMID 29610306 DOI: 10.1073/Pnas.1716029115 |
0.491 |
|
| 2018 |
Kaelin WG. HIF2 Inhibitor Joins the Kidney Cancer Armamentarium. Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology. 36: 908-910. PMID 29384723 DOI: 10.1200/Jco.2017.77.5254 |
0.396 |
|
| 2018 |
Miao D, Margolis CA, Gao W, Voss MH, Li W, Martini DJ, Norton C, Bossé D, Wankowicz SM, Cullen D, Horak C, Wind-Rotolo M, Tracy A, Giannakis M, Hodi FS, ... ... Kaelin WG, et al. Genomic correlates of response to immune checkpoint therapies in clear cell renal cell carcinoma. Science (New York, N.Y.). PMID 29301960 DOI: 10.1126/Science.Aan5951 |
0.437 |
|
| 2018 |
Kaelin WG. Senator McCain and Our Shared Humanity. The American Journal of Medicine. 131: 216-217. PMID 29229468 DOI: 10.1016/J.Amjmed.2017.11.028 |
0.314 |
|
| 2018 |
Kaelin WG. The von Hippel–Lindau Tumor Suppressor Protein Annual Review of Cancer Biology. 2: 91-109. DOI: 10.1146/ANNUREV-CANCERBIO-030617-050527 |
0.328 |
|
| 2017 |
Kaelin WG. Climate Change: What Would Lincoln Do? Jama. 318: 611. PMID 28810027 DOI: 10.1001/Jama.2017.6999 |
0.297 |
|
| 2017 |
Kaelin WG. The VHL Tumor Suppressor Gene: Insights into Oxygen Sensing and Cancer. Transactions of the American Clinical and Climatological Association. 128: 298-307. PMID 28790514 |
0.421 |
|
| 2017 |
Chakraborty AA, Nakamura E, Qi J, Creech A, Jaffe JD, Paulk J, Novak JS, Nagulapalli K, McBrayer SK, Cowley GS, Pineda J, Song J, Wang YE, Carr SA, Root DE, ... ... Kaelin WG, et al. HIF activation causes synthetic lethality between the VHL tumor suppressor and the EZH1 histone methyltransferase. Science Translational Medicine. 9. PMID 28701475 DOI: 10.1126/Scitranslmed.Aal5272 |
0.526 |
|
| 2017 |
Ivan M, Kaelin WG. The EGLN-HIF O2-Sensing System: Multiple Inputs and Feedbacks. Molecular Cell. 66: 772-779. PMID 28622522 DOI: 10.1016/J.Molcel.2017.06.002 |
0.406 |
|
| 2017 |
Kaelin WG. Publish houses of brick, not mansions of straw. Nature. 545: 387. PMID 28541345 DOI: 10.1038/545387a |
0.168 |
|
| 2017 |
Kaelin WG. Common pitfalls in preclinical cancer target validation. Nature Reviews. Cancer. 17: 425-440. PMID 28524181 DOI: 10.1038/Nrc.2017.32 |
0.408 |
|
| 2017 |
Gao W, Li W, Xiao T, Liu XS, Kaelin WG. Inactivation of the PBRM1 tumor suppressor gene amplifies the HIF-response in VHL-/- clear cell renal carcinoma. Proceedings of the National Academy of Sciences of the United States of America. PMID 28082722 DOI: 10.1073/Pnas.1619726114 |
0.52 |
|
| 2017 |
Kaelin WG. Abstract IA29: Targeting undruggable proteins for degradation with small molecules Clinical Cancer Research. 23. DOI: 10.1158/1557-3265.Pmccavuln16-Ia29 |
0.47 |
|
| 2016 |
Cho H, Kaelin WG. Targeting HIF2 in Clear Cell Renal Cell Carcinoma. Cold Spring Harbor Symposia On Quantitative Biology. PMID 27932568 DOI: 10.1101/Sqb.2016.81.030833 |
0.464 |
|
| 2016 |
German NJ, Yoon H, Yusuf RZ, Murphy JP, Finley LW, Laurent G, Haas W, Satterstrom FK, Guarnerio J, Zaganjor E, Santos D, Pandolfi PP, Beck AH, Gygi SP, Scadden DT, ... Kaelin WG, et al. PHD3 Loss in Cancer Enables Metabolic Reliance on Fatty Acid Oxidation via Deactivation of ACC2. Molecular Cell. 63: 1006-1020. PMID 27635760 DOI: 10.1016/J.Molcel.2016.08.014 |
0.427 |
|
| 2016 |
Kaelin WG, Ratcliffe PJ, Semenza GL. Pathways for Oxygen Regulation and Homeostasis: The 2016 Albert Lasker Basic Medical Research Award. Jama. PMID 27622845 DOI: 10.1001/Jama.2016.12386 |
0.614 |
|
| 2016 |
Cho H, Du X, Rizzi JP, Liberzon E, Chakraborty AA, Gao W, Carvo I, Signoretti S, Bruick R, Josey JA, Wallace EM, Kaelin WG. On-Target Efficacy of a HIF2α Antagonist in Preclinical Kidney Cancer Models. Nature. PMID 27595393 DOI: 10.1038/Nature19795 |
0.478 |
|
| 2016 |
Guo J, Chakraborty AA, Liu P, Gan W, Zheng X, Inuzuka H, Wang B, Zhang J, Zhang L, Yuan M, Novak J, Cheng JQ, Toker A, Signoretti S, Zhang Q, ... ... Kaelin WG, et al. pVHL suppresses kinase activity of Akt in a proline-hydroxylation-dependent manner. Science (New York, N.Y.). 353: 929-32. PMID 27563096 DOI: 10.1126/Science.Aad5755 |
0.481 |
|
| 2016 |
Briggs KJ, Koivunen P, Cao S, Backus KM, Olenchock BA, Patel H, Zhang Q, Signoretti S, Gerfen GJ, Richardson AL, Witkiewicz AK, Cravatt BF, Clardy J, Kaelin WG. Paracrine Induction of HIF by Glutamate in Breast Cancer: EglN1 Senses Cysteine. Cell. 166: 126-139. PMID 27368101 DOI: 10.1016/J.Cell.2016.05.042 |
0.342 |
|
| 2016 |
Olenchock BA, Moslehi J, Baik AH, Davidson SM, Williams J, Gibson WJ, Chakraborty AA, Pierce KA, Miller CM, Hanse EA, Kelekar A, Sullivan LB, Wagers AJ, Clish CB, Vander Heiden MG, ... Kaelin WG, et al. EGLN1 Inhibition and Rerouting of α-Ketoglutarate Suffice for Remote Ischemic Protection. Cell. 165: 497. PMID 27058668 DOI: 10.1016/J.Cell.2016.03.037 |
0.331 |
|
| 2016 |
Olenchock BA, Moslehi J, Baik AH, Davidson SM, Williams J, Gibson WJ, Pierce KA, Miller CM, Hanse EA, Kelekar A, Sullivan LB, Wagers AJ, Clish CB, Vander Heiden MG, Kaelin WG. EGLN1 Inhibition and Rerouting of α-Ketoglutarate Suffice for Remote Ischemic Protection. Cell. 164: 884-895. PMID 26919427 DOI: 10.1016/J.Cell.2016.02.006 |
0.397 |
|
| 2015 |
Laukka T, Mariani CJ, Ihantola T, Cao JZ, Hokkanen J, Kaelin WG, Godley LA, Koivunen P. Fumarate and Succinate Regulate Expression of Hypoxia-Inducible Genes via TET Enzymes. The Journal of Biological Chemistry. PMID 26703470 DOI: 10.1074/Jbc.M115.688762 |
0.5 |
|
| 2015 |
Zhang C, Li X, Adelmant G, Dobbins J, Geisen C, Oser MG, Wucherpfenning KW, Marto JA, Kaelin WG. Peptidic degron in EID1 is recognized by an SCF E3 ligase complex containing the orphan F-box protein FBXO21. Proceedings of the National Academy of Sciences of the United States of America. PMID 26631746 DOI: 10.1073/Pnas.1522006112 |
0.477 |
|
| 2015 |
Andronesi OC, Loebel F, Bogner W, Marjanska M, Vander Heiden MG, Iafrate AJ, Dietrich J, Batchelor T, Gerstner ER, Kaelin W, Chi AS, Rosen B, Cahill DP. Treatment response assessment in IDH-mutant glioma patients by non-invasive 3D functional Spectroscopic Mapping of 2-Hydroxyglutarate. Clinical Cancer Research : An Official Journal of the American Association For Cancer Research. PMID 26534967 DOI: 10.1158/1078-0432.Ccr-15-0656 |
0.358 |
|
| 2015 |
Zhang J, Wang C, Chen X, Takada M, Fan C, Zheng X, Wen H, Liu Y, Wang C, Pestell RG, Aird KM, Kaelin WG, Liu XS, Zhang Q. EglN2 associates with the NRF1-PGC1α complex and controls mitochondrial function in breast cancer. The Embo Journal. PMID 26492917 DOI: 10.15252/Embj.201591437 |
0.418 |
|
| 2015 |
Suhara T, Hishiki T, Kasahara M, Hayakawa N, Oyaizu T, Nakanishi T, Kubo A, Morisaki H, Kaelin WG, Suematsu M, Minamishima YA. Inhibition of the oxygen sensor PHD2 in the liver improves survival in lactic acidosis by activating the Cori cycle. Proceedings of the National Academy of Sciences of the United States of America. 112: 11642-7. PMID 26324945 DOI: 10.1073/Pnas.1515872112 |
0.376 |
|
| 2015 |
Kaelin WG. Abstract IA02: Molecular pathogenesis of IDH mutant cancers and evolving treatment strategies Brain. 75. DOI: 10.1158/1538-7445.Brain15-Ia02 |
0.462 |
|
| 2015 |
Middleton RE, Olsen G, McSweeney R, Lu G, Gao W, Roberts J, McKeown MR, Bittinger MA, Wong K, Bradner JE, Kaelin WG. Abstract 5436: Targeting oncoproteins via disruption of proteostasis: Identification of oncoprotein destabilizing agents using luciferase tagged oncoproteins Cancer Research. 75: 5436-5436. DOI: 10.1158/1538-7445.Am2015-5436 |
0.456 |
|
| 2014 |
Kaelin WG. DisABLing kidney cancers caused by fumarate hydratase mutations. Cancer Cell. 26: 779-780. PMID 25490441 DOI: 10.1016/J.Ccell.2014.11.022 |
0.434 |
|
| 2014 |
Couvé S, Ladroue C, Laine E, Mahtouk K, Guégan J, Gad S, Le Jeune H, Le Gentil M, Nuel G, Kim WY, Lecomte B, Pagès JC, Collin C, Lasne F, Benusiglio PR, ... ... Kaelin W, et al. Genetic evidence of a precisely tuned dysregulation in the hypoxia signaling pathway during oncogenesis. Cancer Research. 74: 6554-64. PMID 25371412 DOI: 10.1158/0008-5472.Can-14-1161 |
0.61 |
|
| 2014 |
Lorenzo FR, Huff C, Myllymäki M, Olenchock B, Swierczek S, Tashi T, Gordeuk V, Wuren T, Ri-Li G, McClain DA, Khan TM, Koul PA, Guchhait P, Salama ME, Xing J, ... ... Kaelin WG, et al. A genetic mechanism for Tibetan high-altitude adaptation. Nature Genetics. 46: 951-6. PMID 25129147 DOI: 10.1038/Ng.3067 |
0.543 |
|
| 2014 |
Lu G, Zhang Q, Huang Y, Song J, Tomaino R, Ehrenberger T, Lim E, Liu W, Bronson RT, Bowden M, Brock J, Krop IE, Dillon DA, Gygi SP, Mills GB, ... ... Kaelin WG, et al. Phosphorylation of ETS1 by Src family kinases prevents its recognition by the COP1 tumor suppressor. Cancer Cell. 26: 222-34. PMID 25117710 DOI: 10.1016/J.Ccr.2014.06.026 |
0.469 |
|
| 2014 |
Zheng X, Zhai B, Koivunen P, Shin SJ, Lu G, Liu J, Geisen C, Chakraborty AA, Moslehi JJ, Smalley DM, Wei X, Chen X, Chen Z, Beres JM, Zhang J, ... ... Kaelin WG, et al. Prolyl hydroxylation by EglN2 destabilizes FOXO3a by blocking its interaction with the USP9x deubiquitinase. Genes & Development. 28: 1429-44. PMID 24990963 DOI: 10.1101/Gad.242131.114 |
0.466 |
|
| 2014 |
Choueiri TK, Pal SK, McDermott DF, Morrissey S, Ferguson KC, Holland J, Kaelin WG, Dutcher JP. A phase I study of cabozantinib (XL184) in patients with renal cell cancer. Annals of Oncology : Official Journal of the European Society For Medical Oncology / Esmo. 25: 1603-8. PMID 24827131 DOI: 10.1093/Annonc/Mdu184 |
0.412 |
|
| 2014 |
Akbay EA, Moslehi J, Christensen CL, Saha S, Tchaicha JH, Ramkissoon SH, Stewart KM, Carretero J, Kikuchi E, Zhang H, Cohoon TJ, Murray S, Liu W, Uno K, Fisch S, ... ... Kaelin WG, et al. D-2-hydroxyglutarate produced by mutant IDH2 causes cardiomyopathy and neurodegeneration in mice. Genes & Development. 28: 479-90. PMID 24589777 DOI: 10.1101/Gad.231233.113 |
0.407 |
|
| 2014 |
Lu G, Middleton RE, Sun H, Naniong M, Ott CJ, Mitsiades CS, Wong KK, Bradner JE, Kaelin WG. The myeloma drug lenalidomide promotes the cereblon-dependent destruction of Ikaros proteins. Science (New York, N.Y.). 343: 305-9. PMID 24292623 DOI: 10.1126/Science.1244917 |
0.469 |
|
| 2014 |
Kaelin WG. IDH Mutations, 2-Oxoglutarate-dependent Dioxygenases, and Leukemia Blood. 124: SCI-6-SCI-6. DOI: 10.1182/Blood.V124.21.Sci-6.Sci-6 |
0.408 |
|
| 2014 |
Ott CJ, Lu G, Reyes J, Lin CY, Kaelin WG, Bradner JE. Disruption of the Ikaros-Mediated Gene Expression Program in Multiple Myeloma with Immunomodulatory Agents Blood. 124: 420-420. DOI: 10.1182/Blood.V124.21.420.420 |
0.484 |
|
| 2014 |
Gardie B, Couvé S, Ladroue C, Laine E, Mahtouk K, Guégan J, Gad S, Le Jeune H, Lecomte B, Pagès J, Benusiglio P, Bressac-de Paillerets B, Feunteun J, Dessen P, Hermouet S, ... ... Kaelin WG, et al. A Comprehensive Study of the VHL-R200W Chuvash Polycythemia Mutation Reveals a Gradual Dysregulation of the Hypoxia Pathway in Oncogenesis Blood. 124: 4020-4020. DOI: 10.1182/Blood.V124.21.4020.4020 |
0.589 |
|
| 2013 |
Li L, Shen C, Nakamura E, Ando K, Signoretti S, Beroukhim R, Cowley GS, Lizotte P, Liberzon E, Bair S, Root DE, Tamayo P, Tsherniak A, Cheng SC, Tabak B, ... ... Kaelin WG, et al. SQSTM1 is a pathogenic target of 5q copy number gains in kidney cancer. Cancer Cell. 24: 738-50. PMID 24332042 DOI: 10.1016/J.Ccr.2013.10.025 |
0.405 |
|
| 2013 |
Kaelin W, Livingston D, Loda M, Vousden K, Mihich E. Twenty-fifth annual Pezcoller Symposium: Metabolism and tumorigenesis. Cancer Research. 73: 6124-7. PMID 24097824 DOI: 10.1158/0008-5472.Can-13-2445 |
0.59 |
|
| 2013 |
Losman JA, Kaelin WG. What a difference a hydroxyl makes: mutant IDH, (R)-2-hydroxyglutarate, and cancer. Genes & Development. 27: 836-52. PMID 23630074 DOI: 10.1101/Gad.217406.113 |
0.412 |
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| 2013 |
Kaelin WG, McKnight SL. Influence of metabolism on epigenetics and disease. Cell. 153: 56-69. PMID 23540690 DOI: 10.1016/J.Cell.2013.03.004 |
0.387 |
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| 2013 |
Losman JA, Looper RE, Koivunen P, Lee S, Schneider RK, McMahon C, Cowley GS, Root DE, Ebert BL, Kaelin WG. (R)-2-hydroxyglutarate is sufficient to promote leukemogenesis and its effects are reversible. Science (New York, N.Y.). 339: 1621-5. PMID 23393090 DOI: 10.1126/Science.1231677 |
0.398 |
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| 2013 |
Shen C, Kaelin WG. The VHL/HIF axis in clear cell renal carcinoma. Seminars in Cancer Biology. 23: 18-25. PMID 22705278 DOI: 10.1016/J.Semcancer.2012.06.001 |
0.476 |
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| 2013 |
Baik A, Olenchock B, Moslehi J, Kaelin WG. ACUTE HYPOXIA-INDUCIBLE FACTOR EGLN1 INACTIVATION PROTECTS AGAINST ISCHEMIA-REPERFUSION INJURY BY REGULATION OF GLUCOSE OXIDATION AND REACTIVE OXYGEN SPECIES GENERATION Journal of the American College of Cardiology. 61: E28. DOI: 10.1016/S0735-1097(13)60029-7 |
0.359 |
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| 2012 |
Beshiri ML, Holmes KB, Richter WF, Hess S, Islam AB, Yan Q, Plante L, Litovchick L, Gévry N, Lopez-Bigas N, Kaelin WG, Benevolenskaya EV. Coordinated repression of cell cycle genes by KDM5A and E2F4 during differentiation. Proceedings of the National Academy of Sciences of the United States of America. 109: 18499-504. PMID 23093672 DOI: 10.1073/Pnas.1216724109 |
0.484 |
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| 2012 |
Kaelin WG. Molecular biology. Use and abuse of RNAi to study mammalian gene function. Science (New York, N.Y.). 337: 421-2. PMID 22837515 DOI: 10.1126/Science.1225787 |
0.397 |
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| 2012 |
Querbes W, Bogorad RL, Moslehi J, Wong J, Chan AY, Bulgakova E, Kuchimanchi S, Akinc A, Fitzgerald K, Koteliansky V, Kaelin WG. Treatment of erythropoietin deficiency in mice with systemically administered siRNA. Blood. 120: 1916-22. PMID 22611156 DOI: 10.1182/Blood-2012-04-423715 |
0.365 |
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| 2012 |
Koivunen P, Lee S, Duncan CG, Lopez G, Lu G, Ramkissoon S, Losman JA, Joensuu P, Bergmann U, Gross S, Travins J, Weiss S, Looper R, Ligon KL, Verhaak RG, ... ... Kaelin WG, et al. Transformation by the (R)-enantiomer of 2-hydroxyglutarate linked to EGLN activation. Nature. 483: 484-8. PMID 22343896 DOI: 10.1038/Nature10898 |
0.431 |
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| 2012 |
Yen K, Wang F, Schalm S, Hansen E, Straley K, Kernytsky A, Choe S, Liu W, Popovici-Muller J, Travins J, Yang H, Silverman L, Aurore JL, Kaelin WG, Gross S, et al. Mutation Selective IDH Inhibitors Mediate Histone and DNA Methylation Changes Blood. 120: 3509-3509. DOI: 10.1182/Blood.V120.21.3509.3509 |
0.45 |
|
| 2012 |
Losman J, Looper RE, Kaelin WG. Transformation by Mutant IDH and (R)-2HG Is Reversible. Blood. 120: 2413-2413. DOI: 10.1182/Blood.V120.21.2413.2413 |
0.438 |
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| 2012 |
Yen K, Wang F, Choe S, Schalm S, Hansen E, Straley K, Popovici-Muller J, Travins J, Yang H, Silverman L, Kaelin W, Gross S, Dang L, Salituro F, Saunders J, et al. Abstract LB-164: IDH mutations and tumorgenicity Cancer Research. 72. DOI: 10.1158/1538-7445.Am2012-Lb-164 |
0.47 |
|
| 2011 |
Kaelin WG. Cancer and altered metabolism: potential importance of hypoxia-inducible factor and 2-oxoglutarate-dependent dioxygenases. Cold Spring Harbor Symposia On Quantitative Biology. 76: 335-45. PMID 22089927 DOI: 10.1101/sqb.2011.76.010975 |
0.419 |
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| 2011 |
Shen C, Beroukhim R, Schumacher SE, Zhou J, Chang M, Signoretti S, Kaelin WG. Genetic and functional studies implicate HIF1α as a 14q kidney cancer suppressor gene. Cancer Discovery. 1: 222-35. PMID 22037472 DOI: 10.1158/2159-8290.Cd-11-0098 |
0.474 |
|
| 2011 |
Bass AJ, Lawrence MS, Brace LE, Ramos AH, Drier Y, Cibulskis K, Sougnez C, Voet D, Saksena G, Sivachenko A, Jing R, Parkin M, Pugh T, Verhaak RG, Stransky N, ... ... Kaelin WG, et al. Genomic sequencing of colorectal adenocarcinomas identifies a recurrent VTI1A-TCF7L2 fusion. Nature Genetics. 43: 964-8. PMID 21892161 DOI: 10.1038/Ng.936 |
0.454 |
|
| 2011 |
Lin W, Cao J, Liu J, Beshiri ML, Fujiwara Y, Francis J, Cherniack AD, Geisen C, Blair LP, Zou MR, Shen X, Kawamori D, Liu Z, Grisanzio C, Watanabe H, ... ... Kaelin WG, et al. Loss of the retinoblastoma binding protein 2 (RBP2) histone demethylase suppresses tumorigenesis in mice lacking Rb1 or Men1. Proceedings of the National Academy of Sciences of the United States of America. 108: 13379-86. PMID 21788502 DOI: 10.1073/Pnas.1110104108 |
0.446 |
|
| 2011 |
Li L, Kaelin WG. New insights into the biology of renal cell carcinoma. Hematology/Oncology Clinics of North America. 25: 667-86. PMID 21763962 DOI: 10.1016/J.Hoc.2011.04.004 |
0.427 |
|
| 2011 |
Wei W, Kaelin WG. Good COP1 or bad COP1? In vivo veritas. The Journal of Clinical Investigation. 121: 1263-5. PMID 21403396 DOI: 10.1172/Jci57080 |
0.474 |
|
| 2011 |
Astuti D, Ricketts CJ, Chowdhury R, McDonough MA, Gentle D, Kirby G, Schlisio S, Kenchappa RS, Carter BD, Kaelin WG, Ratcliffe PJ, Schofield CJ, Latif F, Maher ER. Mutation analysis of HIF prolyl hydroxylases (PHD/EGLN) in individuals with features of phaeochromocytoma and renal cell carcinoma susceptibility. Endocrine-Related Cancer. 18: 73-83. PMID 20959442 DOI: 10.1677/Erc-10-0113 |
0.603 |
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| 2011 |
Sorrell AD, Lee S, Stolle C, Ellenhorn J, Grix A, Kaelin WG, Weitzel JN. Clinical and functional properties of novel VHL mutation (X214L) consistent with Type 2A phenotype and low risk of renal cell carcinoma Clinical Genetics. 79: 539-545. PMID 20560986 DOI: 10.1111/J.1399-0004.2010.01464.X |
0.425 |
|
| 2011 |
Rogers LR, LoRusso P, Nadler P, Malik G, Shields A, Kaelin W. Erlotinib therapy for central nervous system hemangioblastomatosis associated with von Hippel-Lindau disease: a case report. Journal of Neuro-Oncology. 101: 307-10. PMID 20524042 DOI: 10.1007/S11060-010-0244-3 |
0.325 |
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| 2011 |
Losman J, Lee S, Koivunen P, Looper RE, Kaelin WG. Enantiomer-Specific Transformation by 2HG Is Linked to Opposing Effects on α-Ketoglutarate-Dependent Dioxygenases Blood. 118: LBA-4-LBA-4. DOI: 10.1182/Blood.V118.21.Lba-4.Lba-4 |
0.437 |
|
| 2011 |
Losman J, Lee S, Koivunen P, Looper RE, Kaelin WG. Enantiomer-Specific Transformation by 2HG Is Linked to Opposing Effects on α-Ketoglutarate-Dependent Dioxygenases Blood. 118: LBA-4-LBA-4. DOI: 10.1182/blood.v118.21.lba-4.bld0076_p2_lba-4 |
0.345 |
|
| 2011 |
Querbes W, Bogorad R, Moslehi J, Akinc A, Wong J, Zurenko C, Qin J, Hettinger J, Kuchimanchi S, Charisse K, Sah DW, Fitzgerald K, Kotelianski V, Kaelin WG. Liver Specific Delivery of siRNA Targeting EGLN Prolyl Hydroxylases Activates Hepatic Erythropoietin Production and Stimulates Erythropoiesis, Blood. 118: 3161-3161. DOI: 10.1182/Blood.V118.21.3161.3161 |
0.429 |
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| 2011 |
Lin W, Francis J, Watanabe H, Yan Q, Kaelin WG, Meyerson M. Abstract 62: Inhibition ofMen1-deficient tumor growth by inactivation of the Rbp2 histone demethylase Cancer Research. 71: 62-62. DOI: 10.1158/1538-7445.Am2011-62 |
0.4 |
|
| 2010 |
Gan B, Lim C, Chu G, Hua S, Ding Z, Collins M, Hu J, Jiang S, Fletcher-Sananikone E, Zhuang L, Chang M, Zheng H, Wang YA, Kwiatkowski DJ, Kaelin WG, et al. FoxOs enforce a progression checkpoint to constrain mTORC1-activated renal tumorigenesis. Cancer Cell. 18: 472-84. PMID 21075312 DOI: 10.1016/J.Ccr.2010.10.019 |
0.408 |
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| 2010 |
Kaelin WG. New cancer targets emerging from studies of the Von Hippel-Lindau tumor suppressor protein. Annals of the New York Academy of Sciences. 1210: 1-7. PMID 20973793 DOI: 10.1111/j.1749-6632.2010.05781.x |
0.458 |
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| 2010 |
Moslehi J, Minamishima YA, Shi J, Neuberg D, Charytan DM, Padera RF, Signoretti S, Liao R, Kaelin WG. Loss of hypoxia-inducible factor prolyl hydroxylase activity in cardiomyocytes phenocopies ischemic cardiomyopathy. Circulation. 122: 1004-16. PMID 20733101 DOI: 10.1161/Circulationaha.109.922427 |
0.422 |
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| 2010 |
Inuzuka H, Tseng A, Gao D, Zhai B, Zhang Q, Shaik S, Wan L, Ang XL, Mock C, Yin H, Stommel JM, Gygi S, Lahav G, Asara J, Xiao ZX, ... Kaelin WG, et al. Phosphorylation by casein kinase I promotes the turnover of the Mdm2 oncoprotein via the SCF(beta-TRCP) ubiquitin ligase. Cancer Cell. 18: 147-59. PMID 20708156 DOI: 10.1016/J.Ccr.2010.06.015 |
0.41 |
|
| 2010 |
Minamishima YA, Kaelin WG. Reactivation of hepatic EPO synthesis in mice after PHD loss. Science (New York, N.Y.). 329: 407. PMID 20651146 DOI: 10.1126/Science.1192811 |
0.39 |
|
| 2010 |
Kaelin WG, Thompson CB. Q&A: Cancer: clues from cell metabolism. Nature. 465: 562-4. PMID 20520704 DOI: 10.1038/465562A |
0.386 |
|
| 2010 |
Loda M, Kaelin WG. Prostate cancer: beta control your hormones. Cancer Cell. 17: 311-2. PMID 20385354 DOI: 10.1016/J.Ccr.2010.03.013 |
0.364 |
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| 2010 |
Bommi-Reddy A, Kaelin WG. Slaying RAS with a synthetic lethal weapon. Cell Research. 20: 119-21. PMID 20118966 DOI: 10.1038/Cr.2010.16 |
0.299 |
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| 2010 |
Moslehi J, Minamishima YA, Padera R, Liao R, Kaelin WG. Loss of PHD Prolyl Hydroxylase Activity in Cardiomyocytes Phenocopies Ischemic Cardiomyopathy Journal of Cardiac Failure. 16: S2. DOI: 10.1016/J.Cardfail.2010.06.010 |
0.342 |
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| 2009 |
Zhang Q, Gu J, Li L, Liu J, Luo B, Cheung HW, Boehm JS, Ni M, Geisen C, Root DE, Polyak K, Brown M, Richardson AL, Hahn WC, Kaelin WG, et al. Control of cyclin D1 and breast tumorigenesis by the EglN2 prolyl hydroxylase. Cancer Cell. 16: 413-24. PMID 19878873 DOI: 10.1016/J.Ccr.2009.09.029 |
0.571 |
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| 2009 |
Kaelin WG. Synthetic lethality: a framework for the development of wiser cancer therapeutics. Genome Medicine. 1: 99. PMID 19863774 DOI: 10.1186/Gm99 |
0.46 |
|
| 2009 |
Kaelin WG. SDH5 mutations and familial paraganglioma: somewhere Warburg is smiling. Cancer Cell. 16: 180-2. PMID 19732718 DOI: 10.1016/J.Ccr.2009.08.013 |
0.384 |
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| 2009 |
Minamishima YA, Moslehi J, Padera RF, Bronson RT, Liao R, Kaelin WG. A feedback loop involving the Phd3 prolyl hydroxylase tunes the mammalian hypoxic response in vivo Molecular and Cellular Biology. 29: 5729-5741. PMID 19720742 DOI: 10.1128/Mcb.00331-09 |
0.452 |
|
| 2009 |
Kim WY, Perera S, Zhou B, Carretero J, Yeh JJ, Heathcote SA, Jackson AL, Nikolinakos P, Ospina B, Naumov G, Brandstetter KA, Weigman VJ, Zaghlul S, Hayes DN, Padera RF, ... ... Kaelin WG, et al. HIF2alpha cooperates with RAS to promote lung tumorigenesis in mice. The Journal of Clinical Investigation. 119: 2160-70. PMID 19662677 DOI: 10.1172/Jci38443 |
0.457 |
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| 2009 |
Beroukhim R, Brunet JP, Di Napoli A, Mertz KD, Seeley A, Pires MM, Linhart D, Worrell RA, Moch H, Rubin MA, Sellers WR, Meyerson M, Linehan WM, Kaelin WG, Signoretti S. Patterns of gene expression and copy-number alterations in von-hippel lindau disease-associated and sporadic clear cell carcinoma of the kidney. Cancer Research. 69: 4674-81. PMID 19470766 DOI: 10.1158/0008-5472.Can-09-0146 |
0.59 |
|
| 2009 |
Atkins MB, Bukowski RM, Escudier BJ, Figlin RA, Hudes GH, Kaelin WG, Linehan WM, McDermott DF, Mier JW, Pedrosa I, Rini BI, Signoretti S, Sosman JA, Teh BT, Wood CG, et al. Innovations and challenges in renal cancer: summary statement from the Third Cambridge Conference. Cancer. 115: 2247-51. PMID 19402064 DOI: 10.1002/Cncr.24229 |
0.379 |
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| 2009 |
Kaelin WG. Treatment of kidney cancer: insights provided by the VHL tumor-suppressor protein. Cancer. 115: 2262-72. PMID 19402056 DOI: 10.1002/Cncr.24232 |
0.516 |
|
| 2009 |
Kim WY, Perera S, Zhou B, Carretero J, Yeh JJ, Heathcote SA, Jackson AL, Nikolinakos P, Ospina B, Naumov GN, Brandstetter KA, Weigman VJ, Zaghlul S, Hayes DN, Padera RF, ... ... Kaelin WG, et al. HIF2α cooperates with RAS to promote lung tumorigenesis in mice (Journal of Clinical Investigation (2009) 119, (2160-2170) doi:101172/JCI38443) Journal of Clinical Investigation. 119: 3182. DOI: 10.1172/Jci38443C1 |
0.326 |
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| 2008 |
Kaelin WG. Kidney cancer: now available in a new flavor. Cancer Cell. 14: 423-4. PMID 19061830 DOI: 10.1016/J.Ccr.2008.11.005 |
0.447 |
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| 2008 |
van Oevelen C, Wang J, Asp P, Yan Q, Kaelin WG, Kluger Y, Dynlacht BD. A role for mammalian Sin3 in permanent gene silencing. Molecular Cell. 32: 359-70. PMID 18995834 DOI: 10.1016/J.Molcel.2008.10.015 |
0.455 |
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| 2008 |
Bommi-Reddy A, Almeciga I, Sawyer J, Geisen C, Li W, Harlow E, Kaelin WG, Grueneberg DA. Kinase requirements in human cells: III. Altered kinase requirements in VHL-/- cancer cells detected in a pilot synthetic lethal screen. Proceedings of the National Academy of Sciences of the United States of America. 105: 16484-9. PMID 18948595 DOI: 10.1073/Pnas.0806574105 |
0.489 |
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| 2008 |
Kaelin WG. The von Hippel-Lindau tumour suppressor protein: O2 sensing and cancer. Nature Reviews. Cancer. 8: 865-73. PMID 18923434 DOI: 10.1038/Nrc2502 |
0.481 |
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| 2008 |
Young AP, Kaelin WG. Senescence triggered by the loss of the VHL tumor suppressor. Cell Cycle (Georgetown, Tex.). 7: 1709-12. PMID 18583945 DOI: 10.4161/Cc.7.12.6124 |
0.394 |
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| 2008 |
Kaelin WG, Ratcliffe PJ. Oxygen sensing by metazoans: the central role of the HIF hydroxylase pathway. Molecular Cell. 30: 393-402. PMID 18498744 DOI: 10.1016/J.Molcel.2008.04.009 |
0.565 |
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| 2008 |
Schlisio S, Kenchappa RS, Vredeveld LC, George RE, Stewart R, Greulich H, Shahriari K, Nguyen NV, Pigny P, Dahia PL, Pomeroy SL, Maris JM, Look AT, Meyerson M, Peeper DS, ... ... Kaelin WG, et al. The kinesin KIF1Bbeta acts downstream from EglN3 to induce apoptosis and is a potential 1p36 tumor suppressor. Genes & Development. 22: 884-93. PMID 18334619 DOI: 10.1101/Gad.1648608 |
0.465 |
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| 2008 |
Young AP, Schlisio S, Minamishima YA, Zhang Q, Li L, Grisanzio C, Signoretti S, Kaelin WG. VHL loss actuates a HIF-independent senescence programme mediated by Rb and p400. Nature Cell Biology. 10: 361-9. PMID 18297059 DOI: 10.1038/Ncb1699 |
0.504 |
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| 2008 |
Minamishima YA, Moslehi J, Bardeesy N, Cullen D, Bronson RT, Kaelin WG. Somatic inactivation of the PHD2 prolyl hydroxylase causes polycythemia and congestive heart failure Blood. 111: 3236-3244. PMID 18096761 DOI: 10.1182/Blood-2007-10-117812 |
0.435 |
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| 2007 |
Kaelin WG, Sawyers CL, Mihich E. Nineteenth Annual Pezcoller Symposium: hypothesis-driven clinical investigation in cancer. Cancer Research. 67: 11102-5. PMID 18045966 DOI: 10.1158/0008-5472.Can-07-3230 |
0.391 |
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| 2007 |
Kaelin WG. Von Hippel-Lindau disease. Annual Review of Pathology. 2: 145-73. PMID 18039096 DOI: 10.1097/00005792-199711000-00001 |
0.517 |
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| 2007 |
Kaelin WG. The von hippel-lindau tumor suppressor protein: an update. Methods in Enzymology. 435: 371-83. PMID 17998064 DOI: 10.1016/S0076-6879(07)35019-2 |
0.5 |
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| 2007 |
Yang H, Minamishima YA, Yan Q, Schlisio S, Ebert BL, Zhang X, Zhang L, Kim WY, Olumi AF, Kaelin WG. pVHL acts as an adaptor to promote the inhibitory phosphorylation of the NF-kappaB agonist Card9 by CK2. Molecular Cell. 28: 15-27. PMID 17936701 DOI: 10.1016/J.Molcel.2007.09.010 |
0.448 |
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| 2007 |
Li L, Zhang L, Zhang X, Yan Q, Minamishima YA, Olumi AF, Mao M, Bartz S, Kaelin WG. Hypoxia-inducible factor linked to differential kidney cancer risk seen with type 2A and type 2B VHL mutations. Molecular and Cellular Biology. 27: 5381-92. PMID 17526729 DOI: 10.1128/Mcb.00282-07 |
0.466 |
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| 2007 |
Klose RJ, Yan Q, Tothova Z, Yamane K, Erdjument-Bromage H, Tempst P, Gilliland DG, Zhang Y, Kaelin WG. The retinoblastoma binding protein RBP2 is an H3K4 demethylase. Cell. 128: 889-900. PMID 17320163 DOI: 10.1016/J.Cell.2007.02.013 |
0.471 |
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| 2007 |
Kaelin WG. The von Hippel-Lindau tumor suppressor protein and clear cell renal carcinoma. Clinical Cancer Research : An Official Journal of the American Association For Cancer Research. 13: 680s-684s. PMID 17255293 DOI: 10.1158/1078-0432.Ccr-06-1865 |
0.48 |
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| 2007 |
Atkins MB, Ernstoff MS, Figlin RA, Flaherty KT, George DJ, Kaelin WG, Kwon ED, Libermann TA, Linehan WM, McDermott DF, Ochoa AC, Pantuck AJ, Rini BI, Rosen MA, Sosman JA, et al. Innovations and challenges in renal cell carcinoma: summary statement from the Second Cambridge Conference. Clinical Cancer Research : An Official Journal of the American Association For Cancer Research. 13: 667s-670s. PMID 17255291 DOI: 10.1158/1078-0432.Ccr-06-2231 |
0.378 |
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| 2007 |
Yan Q, Bartz S, Mao M, Li L, Kaelin WG. The hypoxia-inducible factor 2alpha N-terminal and C-terminal transactivation domains cooperate to promote renal tumorigenesis in vivo. Molecular and Cellular Biology. 27: 2092-102. PMID 17220275 DOI: 10.1128/Mcb.01514-06 |
0.499 |
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| 2007 |
Binné UK, Classon MK, Dick FA, Wei W, Rape M, Kaelin WG, Näär AM, Dyson NJ. Retinoblastoma protein and anaphase-promoting complex physically interact and functionally cooperate during cell-cycle exit. Nature Cell Biology. 9: 225-32. PMID 17187060 DOI: 10.1038/Ncb1532 |
0.492 |
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| 2007 |
Nakamura E, Ogawa O, Kaelin WG. 446: Hypoxia Inducible Factor-Independent Function of PVHL and Its Roles on the Development of Familial Pheochromocytoma Journal of Urology. 177: 149-150. DOI: 10.1016/S0022-5347(18)30699-2 |
0.401 |
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| 2006 |
Nakamura E, Kaelin WG. Recent insights into the molecular pathogenesis of pheochromocytoma and paraganglioma. Endocrine Pathology. 17: 97-106. PMID 17159241 DOI: 10.1385/Ep:17:2:97 |
0.467 |
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| 2006 |
Kim WY, Kaelin WG. Molecular pathways in renal cell carcinoma--rationale for targeted treatment. Seminars in Oncology. 33: 588-95. PMID 17045088 DOI: 10.1053/J.Seminoncol.2006.06.001 |
0.48 |
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| 2006 |
Kim WY, Safran M, Buckley MRM, Ebert BL, Glickman J, Bosenberg M, Regan M, Kaelin WG. Failure to prolyl hydroxylate hypoxia-inducible factor α phenocopies VHL inactivation in vivo Embo Journal. 25: 4650-4662. PMID 16977322 DOI: 10.1038/Sj.Emboj.7601300 |
0.447 |
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| 2006 |
Kaelin WG. The von Hippel-Lindau tumor suppressor protein: roles in cancer and oxygen sensing. Cold Spring Harbor Symposia On Quantitative Biology. 70: 159-66. PMID 16869749 DOI: 10.1101/Sqb.2005.70.001 |
0.545 |
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| 2006 |
Kaelin WG. Cell biology: divining cancer cell weaknesses. Nature. 441: 32-4. PMID 16672958 DOI: 10.1038/441032A |
0.433 |
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| 2006 |
Nakamura E, Abreu-e-Lima P, Awakura Y, Inoue T, Kamoto T, Ogawa O, Kotani H, Manabe T, Zhang GJ, Kondo K, Nosé V, Kaelin WG. Clusterin is a secreted marker for a hypoxia-inducible factor-independent function of the von Hippel-Lindau tumor suppressor protein. The American Journal of Pathology. 168: 574-84. PMID 16436671 DOI: 10.2353/Ajpath.2006.050867 |
0.53 |
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| 2006 |
Safran M, Kim WY, O'Connell F, Flippin L, Günzler V, Horner JW, Depinho RA, Kaelin WG. Mouse model for noninvasive imaging of HIF prolyl hydroxylase activity: assessment of an oral agent that stimulates erythropoietin production. Proceedings of the National Academy of Sciences of the United States of America. 103: 105-10. PMID 16373502 DOI: 10.1073/Pnas.0509459103 |
0.455 |
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| 2005 |
Zhang GJ, Kaelin WG. Bioluminescent imaging of ubiquitin ligase activity: measuring Cdk2 activity in vivo through changes in p27 turnover. Methods in Enzymology. 399: 530-49. PMID 16338380 DOI: 10.1016/S0076-6879(05)99036-8 |
0.448 |
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| 2005 |
Kaelin WG. The von Hippel-Lindau protein, HIF hydroxylation, and oxygen sensing. Biochemical and Biophysical Research Communications. 338: 627-38. PMID 16153592 DOI: 10.1016/J.Bbrc.2005.08.165 |
0.469 |
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| 2005 |
Kaelin WG. The concept of synthetic lethality in the context of anticancer therapy. Nature Reviews. Cancer. 5: 689-98. PMID 16110319 DOI: 10.1038/Nrc1691 |
0.452 |
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| 2005 |
Lee S, Nakamura E, Yang H, Wei W, Linggi MS, Sajan MP, Farese RV, Freeman RS, Carter BD, Kaelin WG, Schlisio S. Neuronal apoptosis linked to EglN3 prolyl hydroxylase and familial pheochromocytoma genes: developmental culling and cancer. Cancer Cell. 8: 155-67. PMID 16098468 DOI: 10.1016/J.Ccr.2005.06.015 |
0.424 |
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| 2005 |
Kaelin WG. ROS: really involved in oxygen sensing. Cell Metabolism. 1: 357-8. PMID 16054083 DOI: 10.1016/J.Cmet.2005.05.006 |
0.375 |
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| 2005 |
Wei W, Jin J, Schlisio S, Harper JW, Kaelin WG. The v-Jun point mutation allows c-Jun to escape GSK3-dependent recognition and destruction by the Fbw7 ubiquitin ligase. Cancer Cell. 8: 25-33. PMID 16023596 DOI: 10.1016/J.Ccr.2005.06.005 |
0.42 |
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| 2005 |
Kaelin WG. Proline hydroxylation and gene expression. Annual Review of Biochemistry. 74: 115-28. PMID 15952883 DOI: 10.1146/Annurev.Biochem.74.082803.133142 |
0.506 |
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| 2005 |
Benevolenskaya EV, Murray HL, Branton P, Young RA, Kaelin WG. Binding of pRB to the PHD protein RBP2 promotes cellular differentiation. Molecular Cell. 18: 623-35. PMID 15949438 DOI: 10.1016/J.Molcel.2005.05.012 |
0.479 |
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| 2005 |
Kaelin WG, Harper JW, Jin J, Kim W, Lee S, Reddy A, Safran M, Schlisio S, Wei W, Yang H, Zhang G. CANCER-RELEVANT CULLIN-RING UBIQUITIN LIGASES Cold Spring Harbor Symposia On Quantitative Biology. 70: 1-1. DOI: 10.1101/Sqb.2004.70.36 |
0.363 |
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| 2005 |
Kaelin WG. von Hippel–Lindau-associated malignancies: Mechanisms and therapeutic opportunities Drug Discovery Today: Disease Mechanisms. 2: 225-231. DOI: 10.1016/J.Ddmec.2005.04.003 |
0.474 |
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| 2004 |
Kim WY, Kaelin WG. Role of VHL gene mutation in human cancer Journal of Clinical Oncology. 22: 4991-5004. PMID 15611513 DOI: 10.1200/Jco.2004.05.061 |
0.53 |
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| 2004 |
Olenyuk BZ, Zhang GJ, Klco JM, Nickols NG, Kaelin WG, Dervan PB. Inhibition of vascular endothelial growth factor with a sequence-specific hypoxia response element antagonist. Proceedings of the National Academy of Sciences of the United States of America. 101: 16768-73. PMID 15556999 DOI: 10.1073/Pnas.0407617101 |
0.462 |
|
| 2004 |
Brugarolas J, Lei K, Hurley RL, Manning BD, Reiling JH, Hafen E, Witters LA, Ellisen LW, Kaelin WG. Regulation of mTOR function in response to hypoxia by REDD1 and the TSC1/TSC2 tumor suppressor complex. Genes & Development. 18: 2893-904. PMID 15545625 DOI: 10.1101/Gad.1256804 |
0.498 |
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| 2004 |
Kaelin WG. The von Hippel-Lindau tumor suppressor gene and kidney cancer. Clinical Cancer Research : An Official Journal of the American Association For Cancer Research. 10: 6290S-5S. PMID 15448019 DOI: 10.1158/1078-0432.Ccr-Sup-040025 |
0.493 |
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| 2004 |
Atkins MB, Avigan DE, Bukowski RM, Childs RW, Dutcher JP, Eisen TG, Figlin RA, Finke JH, Flanigan RC, George DJ, Goldberg SN, Gordon MS, Iliopoulos O, Kaelin WG, Linehan WM, et al. Innovations and challenges in renal cancer: consensus statement from the first international conference. Clinical Cancer Research : An Official Journal of the American Association For Cancer Research. 10: 6277S-81S. PMID 15448017 DOI: 10.1158/1078-0432.Ccr-040720 |
0.37 |
|
| 2004 |
Brugarolas J, Kaelin WG. Dysregulation of HIF and VEGF is a unifying feature of the familial hamartoma syndromes. Cancer Cell. 6: 7-10. PMID 15261137 DOI: 10.1016/J.Ccr.2004.06.020 |
0.473 |
|
| 2004 |
Kaufman B, Scharf O, Arbeit J, Ashcroft M, Brown JM, Bruick RK, Chapman JD, Evans SM, Giaccia AJ, Harris AL, Huang E, Johnson R, Kaelin W, Koch CJ, Maxwell P, et al. Proceedings of the Oxygen Homeostasis/Hypoxia Meeting. Cancer Research. 64: 3350-6. PMID 15126380 DOI: 10.1158/0008-5472.Can-03-2611 |
0.542 |
|
| 2004 |
Zhang GJ, Safran M, Wei W, Sorensen E, Lassota P, Zhelev N, Neuberg DS, Shapiro G, Kaelin WG. Bioluminescent imaging of Cdk2 inhibition in vivo. Nature Medicine. 10: 643-8. PMID 15122251 DOI: 10.1038/Nm1047 |
0.487 |
|
| 2004 |
Mihich E, Kaelin W. Fifteenth annual Pezcoller symposium: molecular in vivo visualization of cancer cells. Cancer Research. 64: 2929-33. PMID 15087414 DOI: 10.1158/0008-5472.Can-03-2995 |
0.396 |
|
| 2004 |
Yang H, Ivan M, Min JH, Kim WY, Kaelin WG. Analysis of von Hippel-Lindau hereditary cancer syndrome: implications of oxygen sensing. Methods in Enzymology. 381: 320-35. PMID 15063684 DOI: 10.1016/S0076-6879(04)81022-X |
0.482 |
|
| 2004 |
Stickle NH, Chung J, Klco JM, Hill RP, Kaelin WG, Ohh M. pVHL modification by NEDD8 is required for fibronectin matrix assembly and suppression of tumor development. Molecular and Cellular Biology. 24: 3251-61. PMID 15060148 DOI: 10.1128/Mcb.24.8.3251-3261.2004 |
0.486 |
|
| 2004 |
Kaelin WG. Gleevec: prototype or outlier? Science's Stke : Signal Transduction Knowledge Environment. 2004: pe12. PMID 15039489 DOI: 10.1126/Stke.2252004Pe12 |
0.438 |
|
| 2004 |
Wei W, Ayad NG, Wan Y, Zhang GJ, Kirschner MW, Kaelin WG. Degradation of the SCF component Skp2 in cell-cycle phase G1 by the anaphase-promoting complex. Nature. 428: 194-8. PMID 15014503 DOI: 10.1038/Nature02381 |
0.455 |
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| 2004 |
Kaelin WG. The von Hippel-Lindau gene, kidney cancer, and oxygen sensing. Journal of the American Society of Nephrology : Jasn. 14: 2703-11. PMID 14569079 DOI: 10.1097/01.Asn.0000092803.69761.41 |
0.431 |
|
| 2004 |
Kaelin W, Kim W, Lee S, Reddy A, Safran M, Yan Q, Yang H. 244 Kidney cancer and the von Hippel-Lindau tumor suppressor protein: implications for therapy European Journal of Cancer Supplements. 2: 76. DOI: 10.1016/S1359-6349(04)80252-0 |
0.345 |
|
| 2003 |
Safran M, Kim WY, Kung AL, Horner JW, DePinho RA, Kaelin WG. Mouse reporter strain for noninvasive bioluminescent imaging of cells that have undergone Cre-mediated recombination. Molecular Imaging. 2: 297-302. PMID 14717328 DOI: 10.1162/153535003322750637 |
0.356 |
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| 2003 |
Kondo K, Kim WY, Lechpammer M, Kaelin WG. Inhibition of HIF2alpha is sufficient to suppress pVHL-defective tumor growth. Plos Biology. 1: E83. PMID 14691554 DOI: 10.1371/Journal.Pbio.0000083 |
0.519 |
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| 2003 |
Kaelin WG. E2F1 as a target: promoter-driven suicide and small molecule modulators. Cancer Biology & Therapy. 2: S48-54. PMID 14508080 DOI: 10.4161/Cbt.202 |
0.526 |
|
| 2003 |
Brugarolas JB, Vazquez F, Reddy A, Sellers WR, Kaelin WG. TSC2 regulates VEGF through mTOR-dependent and -independent pathways. Cancer Cell. 4: 147-58. PMID 12957289 DOI: 10.1016/S1535-6108(03)00187-9 |
0.621 |
|
| 2003 |
George DJ, Kaelin WG. The von Hippel-Lindau protein, vascular endothelial growth factor, and kidney cancer. The New England Journal of Medicine. 349: 419-21. PMID 12890838 DOI: 10.1056/Nejmp030061 |
0.434 |
|
| 2003 |
Irwin MS, Kondo K, Marin MC, Cheng LS, Hahn WC, Kaelin WG. Chemosensitivity linked to p73 function Cancer Cell. 3: 403-410. PMID 12726865 DOI: 10.1016/S1535-6108(03)00078-3 |
0.428 |
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| 2003 |
Ohh M, Kaelin WG. VHL and kidney cancer. Methods in Molecular Biology (Clifton, N.J.). 222: 167-83. PMID 12710686 DOI: 10.1385/1-59259-328-3:167 |
0.372 |
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| 2003 |
Jiang Y, Zhang W, Kondo K, Klco JM, St Martin TB, Dufault MR, Madden SL, Kaelin WG, Nacht M. Gene expression profiling in a renal cell carcinoma cell line: dissecting VHL and hypoxia-dependent pathways. Molecular Cancer Research : McR. 1: 453-62. PMID 12692265 |
0.42 |
|
| 2003 |
Safran M, Kaelin WG. HIF hydroxylation and the mammalian oxygen-sensing pathway Journal of Clinical Investigation. 111: 779-783. PMID 12639980 DOI: 10.1172/Jci18181 |
0.392 |
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| 2003 |
Kim W, Kaelin WG. The von Hippel-Lindau tumor suppressor protein: new insights into oxygen sensing and cancer. Current Opinion in Genetics & Development. 13: 55-60. PMID 12573436 DOI: 10.1016/S0959-437X(02)00010-2 |
0.481 |
|
| 2003 |
Safran M, Kim WY, Kung AL, Horner JW, DePinho RA, Kaelin WG. Mouse Reporter Strain for Noninvasive Bioluminescent Imaging of Cells that have Undergone Cre-Mediated Recombination Molecular Imaging. 2: 153535002003031. DOI: 10.1162/15353500200303154 |
0.244 |
|
| 2002 |
Serebriiskii IG, Mitina O, Pugacheva EN, Benevolenskaya E, Kotova E, Toby GG, Khazak V, Kaelin WG, Chernoff J, Golemis EA. Detection of peptides, proteins, and drugs that selectively interact with protein targets. Genome Research. 12: 1785-91. PMID 12421766 DOI: 10.1101/Gr.450702 |
0.407 |
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| 2002 |
Ivan M, Haberberger T, Gervasi DC, Michelson KS, Günzler V, Kondo K, Yang H, Sorokina I, Conaway RC, Conaway JW, Kaelin WG. Biochemical purification and pharmacological inhibition of a mammalian prolyl hydroxylase acting on hypoxia-inducible factor. Proceedings of the National Academy of Sciences of the United States of America. 99: 13459-64. PMID 12351678 DOI: 10.1073/Pnas.192342099 |
0.642 |
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| 2002 |
Kaelin WG. Molecular basis of the VHL hereditary cancer syndrome. Nature Reviews. Cancer. 2: 673-82. PMID 12209156 DOI: 10.1038/Nrc885 |
0.41 |
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| 2002 |
Aiello LP, George DJ, Cahill MT, Wong JS, Cavallerano J, Hannah AL, Kaelin WG. Rapid and durable recovery of visual function in a patient with von hippel-lindau syndrome after systemic therapy with vascular endothelial growth factor receptor inhibitor su5416. Ophthalmology. 109: 1745-51. PMID 12208726 DOI: 10.1016/S0161-6420(02)01159-4 |
0.335 |
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| 2002 |
Reddy A, Kaelin WG. Using cancer genetics to guide the selection of anticancer drug targets. Current Opinion in Pharmacology. 2: 366-73. PMID 12127868 DOI: 10.1016/S1471-4892(02)00178-9 |
0.455 |
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| 2002 |
Kondo K, Klco J, Nakamura E, Lechpammer M, Kaelin WG. Inhibition of HIF is necessary for tumor suppression by the von Hippel-Lindau protein. Cancer Cell. 1: 237-46. PMID 12086860 DOI: 10.1016/S1535-6108(02)00043-0 |
0.51 |
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| 2002 |
Kaelin WG. How oxygen makes its presence felt. Genes & Development. 16: 1441-5. PMID 12080083 DOI: 10.1101/Gad.1003602 |
0.438 |
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| 2002 |
Min JH, Yang H, Ivan M, Gertler F, Kaelin WG, Pavletich NP. Structure of an HIF-1alpha -pVHL complex: hydroxyproline recognition in signaling. Science (New York, N.Y.). 296: 1886-9. PMID 12004076 DOI: 10.1126/Science.1073440 |
0.428 |
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| 2002 |
Seelan RS, Irwin M, van der Stoop P, Qian C, Kaelin WG, Liu W. The human p73 promoter: characterization and identification of functional E2F binding sites. Neoplasia (New York, N.Y.). 4: 195-203. PMID 11988839 DOI: 10.1038/Sj.Neo.7900237 |
0.471 |
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| 2002 |
Hansen WJ, Ohh M, Moslehi J, Kondo K, Kaelin WG, Welch WJ. Diverse effects of mutations in exon II of the von Hippel-Lindau (VHL) tumor suppressor gene on the interaction of pVHL with the cytosolic chaperonin and pVHL-dependent ubiquitin ligase activity. Molecular and Cellular Biology. 22: 1947-60. PMID 11865071 DOI: 10.1128/Mcb.22.6.1947-1960.2002 |
0.463 |
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| 2002 |
Ohh M, Kim WY, Moslehi JJ, Chen Y, Chau V, Read MA, Kaelin WG. An intact NEDD8 pathway is required for Cullin-dependent ubiquitylation in mammalian cells. Embo Reports. 3: 177-82. PMID 11818338 DOI: 10.1093/Embo-Reports/Kvf028 |
0.447 |
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| 2001 |
Querido E, Blanchette P, Yan Q, Kamura T, Morrison M, Boivin D, Kaelin WG, Conaway RC, Conaway JW, Branton PE. Degradation of p53 by adenovirus E4orf6 and E1B55K proteins occurs via a novel mechanism involving a Cullin-containing complex Genes and Development. 15: 3104-3117. PMID 11731475 DOI: 10.1101/Gad.926401 |
0.644 |
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| 2001 |
Kim TY, Kaelin WG. Differential control of transcription by DNA-bound cyclins. Molecular Biology of the Cell. 12: 2207-17. PMID 11452014 DOI: 10.1091/Mbc.12.7.2207 |
0.466 |
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| 2001 |
Genbacev O, Krtolica A, Kaelin W, Fisher SJ. Human cytotrophoblast expression of the von Hippel-Lindau protein is downregulated during uterine invasion in situ and upregulated by hypoxia in vitro. Developmental Biology. 233: 526-36. PMID 11336512 DOI: 10.1006/Dbio.2001.0231 |
0.414 |
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| 2001 |
Hoffman MA, Ohh M, Yang H, Klco JM, Ivan M, Kaelin WG. von Hippel-Lindau protein mutants linked to type 2C VHL disease preserve the ability to downregulate HIF. Human Molecular Genetics. 10: 1019-27. PMID 11331612 DOI: 10.1093/Hmg/10.10.1019 |
0.499 |
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| 2001 |
Irwin MS, Kaelin WG. Role of the newer p53 family proteins in malignancy. Apoptosis : An International Journal On Programmed Cell Death. 6: 17-29. PMID 11321038 DOI: 10.1023/A:1009663809458 |
0.417 |
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| 2001 |
Ivan M, Kondo K, Yang H, Kim W, Valiando J, Ohh M, Salic A, Asara JM, Lane WS, Kaelin WG. HIFalpha targeted for VHL-mediated destruction by proline hydroxylation: implications for O2 sensing. Science (New York, N.Y.). 292: 464-8. PMID 11292862 DOI: 10.1126/Science.1059817 |
0.455 |
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| 2001 |
Kondo K, Kaelin WG. The von Hippel-Lindau tumor suppressor gene. Experimental Cell Research. 264: 117-25. PMID 11237528 DOI: 10.1006/Excr.2000.5139 |
0.515 |
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| 2000 |
Siegert JL, Rushton JJ, Sellers WR, Kaelin WG, Robbins PD. Cyclin D1 suppresses retinoblastoma protein-mediated inhibition of TAFII250 kinase activity. Oncogene. 19: 5703-11. PMID 11126356 DOI: 10.1038/Sj.Onc.1203966 |
0.596 |
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| 2000 |
Miyake S, Sellers WR, Safran M, Li X, Zhao W, Grossman SR, Gan J, DeCaprio JA, Adams PD, Kaelin WG. Cells degrade a novel inhibitor of differentiation with E1A-like properties upon exiting the cell cycle. Molecular and Cellular Biology. 20: 8889-902. PMID 11073989 DOI: 10.1128/Mcb.20.23.8889-8902.2000 |
0.735 |
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| 2000 |
Irwin M, Marin MC, Phillips AC, Seelan RS, Smith DI, Liu W, Flores ER, Tsai KY, Jacks T, Vousden KH, Kaelin WG. Role for the p53 homologue p73 in E2F-1-induced apoptosis. Nature. 407: 645-8. PMID 11034215 DOI: 10.1038/35036614 |
0.427 |
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| 2000 |
Lissy NA, Davis PK, Irwin M, Kaelin WG, Dowdy SF. A common E2F-1 and p73 pathway mediates cell death induced by TCR activation. Nature. 407: 642-5. PMID 11034214 DOI: 10.1038/35036608 |
0.445 |
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| 2000 |
O'Hagan RC, Ohh M, David G, de Alboran IM, Alt FW, Kaelin WG, DePinho RA. Myc-enhanced expression of Cul1 promotes ubiquitin-dependent proteolysis and cell cycle progression. Genes & Development. 14: 2185-91. PMID 10970882 DOI: 10.1101/Gad.827200 |
0.494 |
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| 2000 |
Ohh M, Park CW, Ivan M, Hoffman MA, Kim TY, Huang LE, Pavletich N, Chau V, Kaelin WG. Ubiquitination of hypoxia-inducible factor requires direct binding to the beta-domain of the von Hippel-Lindau protein. Nature Cell Biology. 2: 423-7. PMID 10878807 DOI: 10.1038/35017054 |
0.45 |
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| 2000 |
Marin MC, Jost CA, Brooks LA, Irwin MS, O'Nions J, Tidy JA, James N, McGregor JM, Harwood CA, Yulug IG, Vousden KH, Allday MJ, Gusterson B, Ikawa S, Hinds PW, ... ... Kaelin WG, et al. A common polymorphism acts as an intragenic modifier of mutant p53 behaviour Nature Genetics. 25: 47-54. PMID 10802655 DOI: 10.1038/75586 |
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| 2000 |
Marin MC, Kaelin WG. p63 and p73: old members of a new family. Biochimica Et Biophysica Acta. 1470: M93-M100. PMID 10799748 DOI: 10.1016/S0304-419X(00)00010-X |
0.356 |
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| 2000 |
Kaelin WG. The p53 gene family. Oncogene. 18: 7701-5. PMID 10618710 DOI: 10.1038/Sj.Onc.1202955 |
0.425 |
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| 2000 |
Kaelin WG. Taking aim at novel molecular targets in cancer therapy. The Journal of Clinical Investigation. 104: 1495. PMID 10587511 DOI: 10.1172/Jci2 |
0.427 |
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| 1999 |
Ohh M, Takagi Y, Aso T, Stebbins CE, Pavletich NP, Zbar B, Conaway RC, Conaway JW, Kaelin WG. Synthetic peptides define critical contacts between elongin C, elongin B, and the von Hippel-Lindau protein Journal of Clinical Investigation. 104: 1583-1591. PMID 10587522 DOI: 10.1172/Jci8161 |
0.618 |
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| 1999 |
Kaelin WG. Choosing anticancer drug targets in the postgenomic era. The Journal of Clinical Investigation. 104: 1503-6. PMID 10587513 DOI: 10.1172/Jci8888 |
0.392 |
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| 1999 |
Kaelin WG. Functions of the retinoblastoma protein. Bioessays : News and Reviews in Molecular, Cellular and Developmental Biology. 21: 950-8. PMID 10517868 DOI: 10.1002/(Sici)1521-1878(199911)21:11<950::Aid-Bies7>3.0.Co;2-D |
0.498 |
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| 1999 |
Lai A, Lee JM, Yang WM, Decaprio JA, Kaelin WG, Seto E, Branton PE. RBP1 recruits both histone deacetylase-dependent and -independent repression activities to retinoblastoma family proteins Molecular and Cellular Biology. 19: 6632-6641. PMID 10490602 DOI: 10.1128/Mcb.19.10.6632 |
0.642 |
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| 1999 |
Koochekpour S, Jeffers M, Wang PH, Gong C, Taylor GA, Roessler LM, Stearman R, Vasselli JR, Stetler-Stevenson WG, Kaelin WG, Linehan WM, Klausner RD, Gnarra JR, Vande Woude GF. The von Hippel-Lindau tumor suppressor gene inhibits hepatocyte growth factor/scatter factor-induced invasion and branching morphogenesis in renal carcinoma cells. Molecular and Cellular Biology. 19: 5902-12. PMID 10454537 DOI: 10.1128/Mcb.19.9.5902 |
0.481 |
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| 1999 |
Gong JG, Costanzo A, Yang HQ, Melino G, Kaelin WG, Levrero M, Wang JY. The tyrosine kinase c-Abl regulates p73 in apoptotic response to cisplatin-induced DNA damage. Nature. 399: 806-9. PMID 10391249 DOI: 10.1038/21690 |
0.443 |
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| 1999 |
Ohh M, Kaelin WG. The von Hippel-Lindau tumour suppressor protein: new perspectives. Molecular Medicine Today. 5: 257-63. PMID 10366821 DOI: 10.1016/S1357-4310(99)01481-1 |
0.494 |
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| 1999 |
Kaelin WG. Cancer. Many vessels, faulty gene. Nature. 399: 203-4. PMID 10353237 DOI: 10.1038/20309 |
0.424 |
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| 1999 |
Kamura T, Koepp DM, Conrad MN, Skowyra D, Moreland RJ, Iliopoulos O, Lane WS, Kaelin WG, Elledge SJ, Conaway RC, Harper JW, Conaway JW. Rbx1, a component of the VHL tumor suppressor complex and SCF ubiquitin ligase Science. 284: 657-661. PMID 10213691 DOI: 10.1126/Science.284.5414.657 |
0.669 |
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| 1999 |
Zeng X, Chen L, Jost CA, Maya R, Keller D, Wang X, Kaelin WG, Oren M, Chen J, Lu H. MDM2 suppresses p73 function without promoting p73 degradation Molecular and Cellular Biology. 19: 3257-3266. PMID 10207051 DOI: 10.1128/Mcb.19.5.3257 |
0.408 |
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| 1999 |
Stebbins CE, Kaelin WG, Pavletich NP. Structure of the VHL-elonginC-elonginB complex: Implications for VHL tumor suppressor function Science. 284: 455-461. PMID 10205047 DOI: 10.1126/Science.284.5413.455 |
0.492 |
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| 1999 |
Kaelin WG. The emerging p53 gene family. Journal of the National Cancer Institute. 91: 594-8. PMID 10203277 DOI: 10.1093/Jnci/91.7.594 |
0.433 |
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| 1999 |
Chen YN, Sharma SK, Ramsey TM, Jiang L, Martin MS, Baker K, Adams PD, Bair KW, Kaelin WG. Selective killing of transformed cells by cyclin/cyclin-dependent kinase 2 antagonists. Proceedings of the National Academy of Sciences of the United States of America. 96: 4325-9. PMID 10200261 DOI: 10.1073/Pnas.96.8.4325 |
0.424 |
|
| 1999 |
Adams PD, Li X, Sellers WR, Baker KB, Leng X, Harper JW, Taya Y, Kaelin WG. Retinoblastoma protein contains a C-terminal motif that targets it for phosphorylation by cyclin-cdk complexes. Molecular and Cellular Biology. 19: 1068-80. PMID 9891042 DOI: 10.1128/Mcb.19.2.1068 |
0.606 |
|
| 1999 |
Kaelin W. The cdk/pRB/E2F pathway in human cancer Kidney International. 56: 1183. DOI: 10.1046/J.1523-1755.1999.0560041183.X |
0.394 |
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| 1999 |
Kaelin WG, Chen YP, Sharma SK, Ramsey TM, Jiang L, Martin MS, Baker K, Adams PD, Parr MJ, Manome Y, Tanaka T, Wen P, Kufe DW, Bair KW, Fine HA. Selective Killing of Cancer Cells based on Derepression of E2F Biochemical Society Transactions. 27: A64-A64. DOI: 10.1042/Bst027A064B |
0.393 |
|
| 1998 |
Adams PD, Kaelin WG. Negative control elements of the cell cycle in human tumors Current Opinion in Cell Biology. 10: 791-797. PMID 9914179 DOI: 10.1016/S0955-0674(98)80123-3 |
0.484 |
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| 1998 |
Kamura T, Sato S, Haque D, Liu L, Kaelin WG, Conaway RC, Conaway JW. The Elongin BC complex interacts with the conserved SOCS-box motif present in members of the SOCS, ras, WD-40 repeat, and ankyrin repeat families Genes and Development. 12: 3872-3881. PMID 9869640 DOI: 10.1101/Gad.12.24.3872 |
0.648 |
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| 1998 |
Kaelin WG, Maher ER. The VHL tumour-suppressor gene paradigm. Trends in Genetics : Tig. 14: 423-6. PMID 9820032 DOI: 10.1016/S0168-9525(98)01558-3 |
0.434 |
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| 1998 |
Marin MC, Jost CA, Irwin MS, DeCaprio JA, Caput D, Kaelin WG. Viral oncoproteins discriminate between p53 and the p53 homolog p73 Molecular and Cellular Biology. 18: 6316-6324. PMID 9774648 DOI: 10.1128/Mcb.18.11.6316 |
0.589 |
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| 1998 |
Iliopoulos O, Ohh M, Kaelin WG. pVHL19 is a biologically active product of the von Hippel-Lindau gene arising from internal translation initiation. Proceedings of the National Academy of Sciences of the United States of America. 95: 11661-6. PMID 9751722 DOI: 10.1073/Pnas.95.20.11661 |
0.48 |
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| 1998 |
Kaelin WG. Another p53 Doppelgänger? Science (New York, N.Y.). 281: 57-8. PMID 9679018 DOI: 10.1126/Science.281.5373.57 |
0.452 |
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| 1998 |
Ohh M, Yauch RL, Lonergan KM, Whaley JM, Stemmer-Rachamimov AO, Louis DN, Gavin BJ, Kley N, Kaelin WG, Iliopoulos O. The von Hippel-Lindau tumor suppressor protein is required for proper assembly of an extracellular fibronectin matrix. Molecular Cell. 1: 959-68. PMID 9651579 DOI: 10.1016/S1097-2765(00)80096-9 |
0.426 |
|
| 1998 |
Lonergan KM, Iliopoulos O, Ohh M, Kamura T, Conaway RC, Conaway JW, Kaelin WG. Regulation of hypoxia-inducible mRNAs by the von Hippel-Lindau tumor suppressor protein requires binding to complexes containing elongins B/C and Cul2 Molecular and Cellular Biology. 18: 732-741. PMID 9447969 DOI: 10.1128/Mcb.18.2.732 |
0.646 |
|
| 1998 |
Sellers WR, Novitch BG, Miyake S, Heith A, Otterson GA, Kaye FJ, Lassar AB, Kaelin WG. Stable binding to E2F is not required for the retinoblastoma protein to activate transcription, promote differentiation, and suppress tumor cell growth. Genes & Development. 12: 95-106. PMID 9420334 DOI: 10.1101/Gad.12.1.95 |
0.66 |
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| 1997 |
Kaelin WG. Alterations in G1/S cell-cycle control contributing to carcinogenesis. Annals of the New York Academy of Sciences. 833: 29-33. PMID 9616737 DOI: 10.1111/j.1749-6632.1997.tb48589.x |
0.472 |
|
| 1997 |
Sellers WR, Kaelin WG. Role of the retinoblastoma protein in the pathogenesis of human cancer Journal of Clinical Oncology. 15: 3301-3312. PMID 9363859 DOI: 10.1200/Jco.1997.15.11.3301 |
0.659 |
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| 1997 |
Parr MJ, Manome Y, Tanaka T, Wen P, Kufe DW, Kaelin WG, Fine HA. Tumor-selective transgene expression in vivo mediated by an E2F-responsive adenoviral vector. Nature Medicine. 3: 1145-9. PMID 9334729 DOI: 10.1038/Nm1097-1145 |
0.493 |
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| 1997 |
Jost CA, Marin MC, Kaelin WG. p73 is a human p53-related protein that can induce apoptosis Nature. 389: 191-194. PMID 9296498 DOI: 10.1038/38298 |
0.481 |
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| 1997 |
Adams PD, Lopez P, Sellers WR, Kaelin WG. Fluorescence-activated cell sorting of transfected cells Methods in Enzymology. 283: 59-72. PMID 9251011 DOI: 10.1016/S0076-6879(97)83007-8 |
0.561 |
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| 1997 |
Kaelin WG. Recent insights into the functions of the retinoblastoma susceptibility gene product. Cancer Investigation. 15: 243-54. PMID 9171859 DOI: 10.3109/07357909709039722 |
0.469 |
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| 1997 |
Corless CL, Kibel AS, Iliopoulos O, Kaelin WG. Immunostaining of the von Hippel-Lindau gene product in normal and neoplastic human tissues. Human Pathology. 28: 459-64. PMID 9104946 DOI: 10.1016/S0046-8177(97)90035-6 |
0.497 |
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| 1997 |
Iliopoulos O, Kaelin WG. The Molecular Basis of Von Hippel-Lindau Disease Molecular Medicine. 3: 289-293. DOI: 10.1007/Bf03401807 |
0.319 |
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| 1996 |
Neuman E, Sellers WR, McNeil JA, Lawrence JB, Kaelin WG. Structure and partial genomic sequence of the human E2F1 gene. Gene. 173: 163-9. PMID 8964493 DOI: 10.1016/0378-1119(96)00184-9 |
0.635 |
|
| 1996 |
Adams PD, Sellers WR, Sharma SK, Wu AD, Nalin CM, Kaelin WG. Identification of a cyclin-cdk2 recognition motif present in substrates and p21-like cyclin-dependent kinase inhibitors Molecular and Cellular Biology. 16: 6623-6633. PMID 8943316 DOI: 10.1128/Mcb.16.12.6623 |
0.599 |
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| 1996 |
Iliopoulos O, Levy AP, Jiang C, Kaelin WG, Goldberg MA. Negative regulation of hypoxia-inducible genes by the von Hippel-Lindau protein. Proceedings of the National Academy of Sciences of the United States of America. 93: 10595-9. PMID 8855223 DOI: 10.1073/Pnas.93.20.10595 |
0.459 |
|
| 1996 |
Grafi G, Burnett RJ, Helentjaris T, Larkins BA, Decaprio JA, Sellers WR, Kaelin WG. A maize cDNA encoding a member of the retinoblastoma protein family: Involvement in endoreduplication Proceedings of the National Academy of Sciences of the United States of America. 93: 8962-8967. PMID 8799136 DOI: 10.1073/Pnas.93.17.8962 |
0.714 |
|
| 1996 |
Sellers WR, Kaelin WG. RB [corrected] as a modulator of transcription Biochimica Et Biophysica Acta. 1288: M1-5. PMID 8764839 DOI: 10.1016/0304-419X(96)00014-5 |
0.627 |
|
| 1996 |
Jost CA, Ginsberg D, Kaelin WG. A conserved region of unknown function participates in the recognition of E2F family members by the adenovirus E4 ORF 6/7 protein Virology. 220: 78-90. PMID 8659131 DOI: 10.1006/Viro.1996.0288 |
0.471 |
|
| 1996 |
Field SJ, Tsai FY, Kuo F, Zubiaga AM, Kaelin WG, Livingston DM, Orkin SH, Greenberg ME. E2F-1 functions in mice to promote apoptosis and suppress proliferation. Cell. 85: 549-61. PMID 8653790 DOI: 10.1016/S0092-8674(00)81255-6 |
0.586 |
|
| 1996 |
Adams PD, Kaelin WG. The cellular effects of E2F overexpression Current Topics in Microbiology and Immunology. 208: 79-93. PMID 8575214 DOI: 10.1007/978-3-642-79910-5_4 |
0.505 |
|
| 1996 |
Sellers WR, Kaelin WG. Erratum to ‘RB as a modulator of transcription’ [Biochim. Biophys. Acta 1288 (1996) M1–M5] Biochimica Et Biophysica Acta (Bba) - Reviews On Cancer. 1288: E1. DOI: 10.1016/S0304-419X(96)00035-2 |
0.502 |
|
| 1996 |
Sellers WR, Kaelin WG. xRB as a modulator of transcription Biochimica Et Biophysica Acta - Reviews On Cancer. 1288: M1-M5. DOI: 10.1016/0304-419X(96)00014-5 |
0.513 |
|
| 1995 |
Sellers WR, Rodgers JW, Kaelin WG. A potent transrepression domain in the retinoblastoma protein induces a cell cycle arrest when bound to E2F sites Proceedings of the National Academy of Sciences of the United States of America. 92: 11544-11548. PMID 8524800 DOI: 10.1073/Pnas.92.25.11544 |
0.625 |
|
| 1995 |
Qin XQ, Livingston DM, Ewen M, Sellers WR, Arany Z, Kaelin WG. The transcription factor E2F-1 is a downstream target of RB action. Molecular and Cellular Biology. 15: 742-55. PMID 7823942 DOI: 10.1128/Mcb.15.2.742 |
0.783 |
|
| 1995 |
Kibel A, Iliopoulos O, DeCaprio JA, Kaelin WG. Binding of the von Hippel-Lindau tumor suppressor protein to Elongin B and C Science. 269: 1444-1446. PMID 7660130 DOI: 10.1126/Science.7660130 |
0.645 |
|
| 1995 |
Adams PD, Kaelin WG. Transcriptional control by E2F Seminars in Cancer Biology. 6: 99-108. PMID 7647312 DOI: 10.1006/Scbi.1995.0013 |
0.491 |
|
| 1995 |
Neuman E, Flemington EK, Sellers WR, Kaelin WG. Transcription of the E2F-1 gene is rendered cell cycle dependent by E2F DNA-binding sites within its promoter Molecular and Cellular Biology. 15: 4660. PMID 7623859 |
0.569 |
|
| 1995 |
Iliopoulos O, Kibel A, Gray S, Kaelin WG. Tumour suppression by the human von Hippel-Lindau gene product. Nature Medicine. 1: 822-6. PMID 7585187 DOI: 10.1038/Nm0895-822 |
0.475 |
|
| 1994 |
Li Y, Slansky JE, Myers DJ, Drinkwater NR, Kaelin WG, Farnham PJ. Cloning, chromosomal location, and characterization of mouse E2F1. Molecular and Cellular Biology. 14: 1861-9. PMID 8114719 DOI: 10.1128/Mcb.14.3.1861 |
0.486 |
|
| 1994 |
Krek W, Ewen ME, Shirodkar S, Arany Z, Kaelin WG, Livingston DM. Negative regulation of the growth-promoting transcription factor E2F-1 by a stably bound cyclin A-dependent protein kinase Cell. 78: 161-172. PMID 8033208 DOI: 10.1016/0092-8674(94)90582-7 |
0.738 |
|
| 1994 |
Qin XQ, Livingston DM, Kaelin WG, Adams PD. Deregulated transcription factor E2F-1 expression leads to S-phase entry and p53-mediated apoptosis Proceedings of the National Academy of Sciences of the United States of America. 91: 10918-10922. PMID 7971984 DOI: 10.1073/Pnas.91.23.10918 |
0.597 |
|
| 1994 |
Neuman E, Flemington EK, Sellers WR, Kaelin WG. Transcription of the E2F-1 gene is rendered cell cycle dependent by E2F DNA-binding sites within its promoter. Molecular and Cellular Biology. 14: 6607-15. PMID 7935380 DOI: 10.1128/Mcb.14.10.6607 |
0.642 |
|
| 1993 |
Wang CY, Petryniak B, Thompson CB, Kaelin WG, Leiden JM. Regulation of the Ets-related transcription factor Elf-1 by binding to the retinoblastoma protein. Science (New York, N.Y.). 260: 1330-5. PMID 8493578 DOI: 10.1126/Science.8493578 |
0.501 |
|
| 1993 |
Slansky JE, Li Y, Kaelin WG, Farnham PJ. A protein synthesis-dependent increase in E2F1 mRNA correlates with growth regulation of the dihydrofolate reductase promoter. Molecular and Cellular Biology. 13: 1610-8. PMID 8441401 DOI: 10.1128/Mcb.13.3.1610 |
0.478 |
|
| 1993 |
Livingston DM, Kaelin W, Chittenden T, Qin X. Structural and functional contributions to the G1 blocking action of the retinoblastoma protein. (the 1992 Gordon Hamilton Fairley Memorial Lecture) British Journal of Cancer. 68: 264-268. PMID 8347480 DOI: 10.1038/bjc.1993.325 |
0.539 |
|
| 1993 |
Flemington EK, Speck SH, Kaelin WG. E2F-1-mediated transactivation is inhibited by complex formation with the retinoblastoma susceptibility gene product Proceedings of the National Academy of Sciences of the United States of America. 90: 6914-6918. PMID 8346196 DOI: 10.1073/Pnas.90.15.6914 |
0.49 |
|
| 1992 |
Walling DM, Kaelin WG. Pyomyositis in patients with diabetes mellitus. Reviews of Infectious Diseases. 13: 797-802. PMID 1962087 DOI: 10.1093/Clinids/13.5.797 |
0.308 |
|
| 1992 |
Kaelin WG, Krek W, Sellers WR, DeCaprio JA, Ajchenbaum F, Fuchs CS, Chittenden T, Li Y, Farnham PJ, Blanar MA. Expression cloning of a cDNA encoding a retinoblastoma-binding protein with E2F-like properties. Cell. 70: 351-64. PMID 1638635 DOI: 10.1016/0092-8674(92)90108-O |
0.714 |
|
| 1992 |
Qin XQ, Chittenden T, Livingston DM, Kaelin WG. Identification of a growth suppression domain within the retinoblastoma gene product Genes and Development. 6: 953-964. PMID 1534305 DOI: 10.1101/Gad.6.6.953 |
0.598 |
|
| 1991 |
Chittenden T, Livingston DM, Kaelin WG. The T/E1A-binding domain of the retinoblastoma product can interact selectively with a sequence-specific DNA-binding protein Cell. 65: 1073-1082. PMID 1828394 DOI: 10.1016/0092-8674(91)90559-H |
0.579 |
|
| 1991 |
Kaelin WG, Pallas DC, DeCaprio JA, Kaye FJ, Livingston DM. Identification of cellular proteins that can interact specifically with the T/ElA-binding region of the retinoblastoma gene product Cell. 64: 521-532. PMID 1825028 DOI: 10.1016/0092-8674(91)90236-R |
0.697 |
|
| 1991 |
Chittenden T, Livingston DM, Kaelin WG. RB associates with an E2F-like, sequence-specific DNA-binding protein Cold Spring Harbor Symposia On Quantitative Biology. 56: 187-195. PMID 1819485 DOI: 10.1101/Sqb.1991.056.01.024 |
0.56 |
|
| 1990 |
Kaelin WG, Ewen ME, Livingston DM. Definition of the minimal simian virus 40 large T antigen- and adenovirus E1A-binding domain in the retinoblastoma gene product Molecular and Cellular Biology. 10: 3761-3769. PMID 2162480 DOI: 10.1128/Mcb.10.7.3761 |
0.708 |
|
| 1986 |
Kaelin WG, Spivak JL. Systemic lupus erythematosus and myelofibrosis. The American Journal of Medicine. 81: 935-8. PMID 3777001 DOI: 10.1016/0002-9343(86)90373-6 |
0.328 |
|
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