Nobuko Uchida, Ph.D. - Publications

Affiliations: 
R&D BOCO Silicon Valley 

66 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2023 Liu DD, He JQ, Uchida N, Weissman IL, Sinha R. Prospective isolation of neural stem and progenitor cells from the developing human brain. Star Protocols. 4: 102674. PMID 37897731 DOI: 10.1016/j.xpro.2023.102674  0.813
2023 Liu DD, He JQ, Sinha R, Eastman AE, Toland AM, Morri M, Neff NF, Vogel H, Uchida N, Weissman IL. Purification and characterization of human neural stem and progenitor cells. Cell. 186: 1179-1194.e15. PMID 36931245 DOI: 10.1016/j.cell.2023.02.017  0.758
2021 Beinat C, Patel CB, Haywood T, Murty S, Naya L, Castillo JB, Reyes ST, Phillips M, Buccino P, Shen B, Park JH, Koran ME, Alam IS, James ML, Holley D, ... ... Uchida N, et al. A Clinical PET Imaging Tracer ([F]DASA-23) to Monitor Pyruvate Kinase M2 Induced Glycolytic Reprogramming in Glioblastoma. Clinical Cancer Research : An Official Journal of the American Association For Cancer Research. PMID 34475101 DOI: 10.1158/1078-0432.CCR-21-0544  0.731
2020 Martin RM, Fowler JL, Cromer MK, Lesch BJ, Ponce E, Uchida N, Nishimura T, Porteus MH, Loh KM. Improving the safety of human pluripotent stem cell therapies using genome-edited orthogonal safeguards. Nature Communications. 11: 2713. PMID 32483127 DOI: 10.1038/S41467-020-16455-7  0.748
2019 Dever DP, Scharenberg SG, Camarena J, Kildebeck EJ, Clark JT, Martin RM, Bak RO, Tang Y, Dohse M, Birgmeier JA, Jagadeesh KA, Bejerano G, Tsukamoto A, Gomez-Ospina N, Uchida N, et al. CRISPR/Cas9 Genome Engineering in Engraftable Human Brain-Derived Neural Stem Cells. Iscience. 15: 524-535. PMID 31132746 DOI: 10.1016/J.Isci.2019.04.036  0.498
2019 Martin RM, Ikeda K, Cromer MK, Uchida N, Nishimura T, Romano R, Tong AJ, Lemgart VT, Camarena J, Pavel-Dinu M, Sindhu C, Wiebking V, Vaidyanathan S, Dever DP, Bak RO, et al. Highly Efficient and Marker-free Genome Editing of Human Pluripotent Stem Cells by CRISPR-Cas9 RNP and AAV6 Donor-Mediated Homologous Recombination. Cell Stem Cell. 24: 821-828.e5. PMID 31051134 DOI: 10.1016/J.Stem.2019.04.001  0.784
2018 Ikeda K, Uchida N, Nishimura T, White J, Martin RM, Nakauchi H, Sebastiano V, Weinberg KI, Porteus MH. Efficient scarless genome editing in human pluripotent stem cells. Nature Methods. 15: 1045-1047. PMID 30504872 DOI: 10.1038/S41592-018-0212-Y  0.507
2017 Nguyen HX, Hooshmand MJ, Saiwai H, Maddox J, Salehi A, Lakatos A, Nishi R, Salazar D, Uchida N, Anderson AJ. Systemic neutrophil depletion modulates the migration and fate of transplanted human neural stem cells to rescue functional repair. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. PMID 28847814 DOI: 10.1523/Jneurosci.2785-16.2017  0.549
2017 Hooshmand MJ, Nguyen HX, Piltti KM, Benavente F, Hong S, Flanagan L, Uchida N, Cummings BJ, Anderson AJ. Neutrophils Induce Astroglial Differentiation and Migration of Human Neural Stem Cells via C1q and C3a Synthesis. Journal of Immunology (Baltimore, Md. : 1950). PMID 28687659 DOI: 10.4049/Jimmunol.1600064  0.455
2017 Piltti KM, Funes GM, Avakian SN, Salibian AA, Huang KI, Carta K, Kamei N, Flanagan LA, Monuki ES, Uchida N, Cummings BJ, Anderson AJ. Increasing Human Neural Stem Cell Transplantation Dose Alters Oligodendroglial and Neuronal Differentiation after Spinal Cord Injury. Stem Cell Reports. PMID 28479305 DOI: 10.1016/J.Stemcr.2017.04.009  0.519
2017 Fujiwara H, Fuji S, Wake A, Kato K, Takatsuka Y, Fukuda T, Taguchi J, Uchida N, Miyamoto T, Hidaka M, Miyazaki Y, Tomoyose T, Onizuka M, Takanashi M, Ichinohe T, et al. Dismal outcome of allogeneic hematopoietic stem cell transplantation for relapsed adult T-cell leukemia/lymphoma, a Japanese nation-wide study. Bone Marrow Transplantation. PMID 28067877 DOI: 10.1038/Bmt.2016.313  0.598
2016 Dever DP, Bak RO, Reinisch A, Camarena J, Washington G, Nicolas CE, Pavel-Dinu M, Saxena N, Wilkens AB, Mantri S, Uchida N, Hendel A, Narla A, Majeti R, Weinberg KI, et al. CRISPR/Cas9 β-globin gene targeting in human haematopoietic stem cells. Nature. PMID 27820943 DOI: 10.1038/Nature20134  0.682
2016 Dever DP, Bak RO, Camarena J, Saxena N, Reinisch A, Nicolas CE, Wilkens AB, Hendel A, Uchida N, Majeti R, Weinberg KI, Porteus MH. 39. FACS-Based Enrichment of a Highly Purified HBB-Targeted Hematopoietic Stem and Progenitor Cell Population Using rAAV6 and CRISPR/Cas9 Molecular Therapy. 24: S17. DOI: 10.1016/S1525-0016(16)32848-9  0.69
2015 Aoki J, Seo S, Kanamori H, Tanaka M, Fukuda T, Onizuka M, Kobayashi N, Kondo T, Sawa M, Uchida N, Iwato K, Icihnohe T, Atsuta Y, Yano S, Takami A. Impact of low-dose TBI on outcomes of reduced intensity conditioning allogeneic hematopoietic stem cell transplantation for AML. Bone Marrow Transplantation. PMID 26642343 DOI: 10.1038/Bmt.2015.297  0.354
2015 Piltti KM, Avakian SN, Funes GM, Hu A, Uchida N, Anderson AJ, Cummings BJ. Transplantation dose alters the dynamics of human neural stem cell engraftment, proliferation and migration after spinal cord injury. Stem Cell Research. 15: 341-53. PMID 26298025 DOI: 10.1016/J.Scr.2015.07.001  0.509
2014 Sontag CJ, Uchida N, Cummings BJ, Anderson AJ. Injury to the spinal cord niche alters the engraftment dynamics of human neural stem cells. Stem Cell Reports. 2: 620-32. PMID 24936450 DOI: 10.1016/J.Stemcr.2014.03.005  0.541
2013 Piltti KM, Salazar DL, Uchida N, Cummings BJ, Anderson AJ. Safety of human neural stem cell transplantation in chronic spinal cord injury. Stem Cells Translational Medicine. 2: 961-74. PMID 24191264 DOI: 10.5966/Sctm.2013-0064  0.442
2013 Tsukamoto A, Uchida N, Capela A, Gorba T, Huhn S. Clinical translation of human neural stem cells. Stem Cell Research & Therapy. 4: 102. PMID 23987648 DOI: 10.1186/Scrt313  0.583
2013 Sontag CJ, Nguyen HX, Kamei N, Uchida N, Anderson AJ, Cummings BJ. Immunosuppressants affect human neural stem cells in vitro but not in an in vivo model of spinal cord injury. Stem Cells Translational Medicine. 2: 731-44. PMID 23981724 DOI: 10.5966/Sctm.2012-0175  0.469
2013 Piltti KM, Salazar DL, Uchida N, Cummings BJ, Anderson AJ. Safety of epicenter versus intact parenchyma as a transplantation site for human neural stem cells for spinal cord injury therapy. Stem Cells Translational Medicine. 2: 204-16. PMID 23413374 DOI: 10.5966/Sctm.2012-0110  0.419
2012 Uchida N, Chen K, Dohse M, Hansen KD, Dean J, Buser JR, Riddle A, Beardsley DJ, Wan Y, Gong X, Nguyen T, Cummings BJ, Anderson AJ, Tamaki SJ, Tsukamoto A, et al. Human neural stem cells induce functional myelination in mice with severe dysmyelination. Science Translational Medicine. 4: 155ra136. PMID 23052293 DOI: 10.1126/Scitranslmed.3004371  0.517
2012 Uchida N, Chen K, Dohse M, Hansen KD, Dean J, Buser JR, Riddle A, Beardsley DJ, Wan Y, Gong X, Nguyen T, Cummings BJ, Anderson AJ, Tamaki SJ, Tsukamoto A, et al. Human neural stem cells induce functional myelination in mice with severe dysmyelination (Science Translational Medicine (2012) 4, (165er7)) Science Translational Medicine. 4. DOI: 10.1126/Scitranslmed.3005469  0.588
2011 Hook L, Vives J, Fulton N, Leveridge M, Lingard S, Bootman MD, Falk A, Pollard SM, Allsopp TE, Dalma-Weiszhausz D, Tsukamoto A, Uchida N, Gorba T. Non-immortalized human neural stem (NS) cells as a scalable platform for cellular assays. Neurochemistry International. 59: 432-44. PMID 21762743 DOI: 10.1016/J.Neuint.2011.06.024  0.589
2010 Salazar DL, Uchida N, Hamers FP, Cummings BJ, Anderson AJ. Human neural stem cells differentiate and promote locomotor recovery in an early chronic spinal cord injury NOD-scid mouse model. Plos One. 5: e12272. PMID 20806064 DOI: 10.1371/Journal.Pone.0012272  0.409
2010 Uchida N. MicroRNA-9 controls a migratory mechanism in human neural progenitor cells. Cell Stem Cell. 6: 294-6. PMID 20362531 DOI: 10.1016/j.stem.2010.03.010  0.403
2010 Hooshmand M, Nguyen H, Tamaki S, Uchida N, Cummings B, Anderson A. Neutrophil-derived C1q and C3a promote migration and astroglial differentiation of human fetal neural stem cells transplanted immediately after spinal cord injury in immunodeficient mice Molecular Immunology. 47: 2251-2251. DOI: 10.1016/J.Molimm.2010.05.162  0.357
2009 Tamaki SJ, Jacobs Y, Dohse M, Capela A, Cooper JD, Reitsma M, He D, Tushinski R, Belichenko PV, Salehi A, Mobley W, Gage FH, Huhn S, Tsukamoto AS, Weissman IL, ... Uchida N, et al. Neuroprotection of host cells by human central nervous system stem cells in a mouse model of infantile neuronal ceroid lipofuscinosis. Cell Stem Cell. 5: 310-9. PMID 19733542 DOI: 10.1016/J.Stem.2009.05.022  0.562
2009 Hooshmand MJ, Sontag CJ, Uchida N, Tamaki S, Anderson AJ, Cummings BJ. Analysis of host-mediated repair mechanisms after human CNS-stem cell transplantation for spinal cord injury: correlation of engraftment with recovery. Plos One. 4: e5871. PMID 19517014 DOI: 10.1371/Journal.Pone.0005871  0.444
2008 Xiong A, Austin TW, Lagasse E, Uchida N, Tamaki S, Bordier BB, Weissman IL, Glenn JS, Millan MT. Isolation of human fetal liver progenitors and their enhanced proliferation by three-dimensional coculture with endothelial cells. Tissue Engineering. Part A. 14: 995-1006. PMID 19230124 DOI: 10.1089/Ten.Tea.2007.0087  0.715
2008 Xiong A, Austin TW, Lagasse E, Uchida N, Tamaki S, Bordier BB, Weissman IL, Glenn JS, Millan MT. Isolation of human fetal liver progenitors and their enhanced proliferation by three-dimensional coculture with endothelial cells Tissue Engineering - Part a.. 14: 995-1006. DOI: 10.1089/ten.tea.2007.0087  0.711
2007 Guzman R, Uchida N, Bliss TM, He D, Christopherson KK, Stellwagen D, Capela A, Greve J, Malenka RC, Moseley ME, Palmer TD, Steinberg GK. Long-term monitoring of transplanted human neural stem cells in developmental and pathological contexts with MRI. Proceedings of the National Academy of Sciences of the United States of America. 104: 10211-6. PMID 17553967 DOI: 10.1073/Pnas.0608519104  0.52
2007 Steiner R, Koch T, Al-Uzri A, Uchida N, Tamaki S, Tsukamoto A, Guillaume D, Selden N. 26 A phase I clinical study of human CNS stem cells (HUCNS-SC) in patients with neuronal ceroid lipofuscinosis Molecular Genetics and Metabolism. 92: 17. DOI: 10.1016/J.Ymgme.2007.08.031  0.38
2006 Cummings BJ, Uchida N, Tamaki SJ, Anderson AJ. Human neural stem cell differentiation following transplantation into spinal cord injured mice: association with recovery of locomotor function. Neurological Research. 28: 474-81. PMID 16808875 DOI: 10.1179/016164106X115116  0.578
2006 Carlson GA, Wilson C, Young R, Turner S, Westaway D, Ashe KH, Tsukamoto A, Eckert K, Dohse M, Patel P, Tushinski R, Tamaki S, Uchida N. P4-370: Long-term survival of human CNS stem cells and their progeny in immunodeficient, plaque-producing APP transgenic mice Alzheimers & Dementia. 2. DOI: 10.1016/J.Jalz.2006.05.2111  0.458
2005 Cummings BJ, Uchida N, Tamaki SJ, Salazar DL, Hooshmand M, Summers R, Gage FH, Anderson AJ. Human neural stem cells differentiate and promote locomotor recovery in spinal cord-injured mice. Proceedings of the National Academy of Sciences of the United States of America. 102: 14069-74. PMID 16172374 DOI: 10.1073/Pnas.0507063102  0.44
2004 Baiker A, Fabel K, Cozzio A, Zerboni L, Fabel K, Sommer M, Uchida N, He D, Weissman I, Arvin AM. Varicella-zoster virus infection of human neural cells in vivo. Proceedings of the National Academy of Sciences of the United States of America. 101: 10792-7. PMID 15247414 DOI: 10.1073/Pnas.0404016101  0.565
2004 Xiong A, Lagasse E, Uchida N, Austin T, Tamaki S, Weissman I, Millan M. Angiogenesis enhances the survival of cultured human fetal liver cells Journal of the American College of Surgeons. 199: 97. DOI: 10.1016/J.Jamcollsurg.2004.05.214  0.704
2002 Reitsma MJ, Lee BR, Uchida N. Method for purification of human hematopoietic stem cells by flow cytometry. Methods in Molecular Medicine. 63: 59-77. PMID 21437800 DOI: 10.1385/1-59259-140-X:059  0.485
2002 Tamaki S, Eckert K, He D, Sutton R, Doshe M, Jain G, Tushinski R, Reitsma M, Harris B, Tsukamoto A, Gage F, Weissman I, Uchida N. Engraftment of sorted/expanded human central nervous system stem cells from fetal brain. Journal of Neuroscience Research. 69: 976-86. PMID 12205691 DOI: 10.1002/Jnr.10412  0.647
2001 Lagasse E, Shizuru JA, Uchida N, Tsukamoto A, Weissman IL. Toward regenerative medicine. Immunity. 14: 425-36. PMID 11336688 DOI: 10.1016/S1074-7613(01)00123-6  0.81
2000 Uchida N, Buck DW, He D, Reitsma MJ, Masek M, Phan TV, Tsukamoto AS, Gage FH, Weissman IL. Direct isolation of human central nervous system stem cells. Proceedings of the National Academy of Sciences of the United States of America. 97: 14720-5. PMID 11121071 DOI: 10.1073/Pnas.97.26.14720  0.596
2000 Fukuyama T, Otsuka T, Shigematsu H, Uchida N, Arima F, Ohno Y, Iwasaki H, Fukuda T, Niho Y. Proliferative involvement of ENX-1, a putative human polycomb group gene, in haematopoietic cells. British Journal of Haematology. 108: 842-7. PMID 10792293 DOI: 10.1046/j.1365-2141.2000.01914.x  0.322
1999 Murray LJ, Bruno E, Uchida N, Hoffman R, Nayar R, Yeo EL, Schuh AC, Sutherland DR. CD109 is expressed on a subpopulation of CD34+ cells enriched in hematopoietic stem and progenitor cells. Experimental Hematology. 27: 1282-1294. PMID 10428505 DOI: 10.1016/S0301-472X(99)00071-5  0.34
1999 Sutton RE, Reitsma MJ, Uchida N, Brown PO. Transduction of human progenitor hematopoietic stem cells by human immunodeficiency virus type 1-based vectors is cell cycle dependent. Journal of Virology. 73: 3649-60. PMID 10196257 DOI: 10.1128/Jvi.73.5.3649-3660.1999  0.529
1999 Cortés F, Deschaseaux F, Uchida N, Labastie M, Friera AM, He D, Charbord P, Péault B. HCA, an Immunoglobulin-Like Adhesion Molecule Present on the Earliest Human Hematopoietic Precursor Cells, Is Also Expressed by Stromal Cells in Blood-Forming Tissues Blood. 93: 826-837. DOI: 10.1182/Blood.V93.3.826.403K28_826_837  0.451
1998 Uchida N, Sutton RE, Friera AM, He D, Reitsma MJ, Chang WC, Veres G, Scollay R, Weissman IL. HIV, but not murine leukemia virus, vectors mediate high efficiency gene transfer into freshly isolated G0/G1 human hematopoietic stem cells. Proceedings of the National Academy of Sciences of the United States of America. 95: 11939-44. PMID 9751769 DOI: 10.1073/Pnas.95.20.11939  0.772
1997 Aguila HL, Akashi K, Domen J, Gandy KL, Lagasse E, Mebius RE, Morrison SJ, Shizuru J, Strober S, Uchida N, Wright DE, Weissman IL. From stem cells to lymphocytes: biology and transplantation. Immunological Reviews. 157: 13-40. PMID 9255619 DOI: 10.1111/J.1600-065X.1997.Tb00971.X  0.804
1997 Uchida N, Yang Z, Combs J, Pourquié O, Nguyen M, Ramanathan R, Fu J, Welply A, Chen S, Weddell G, Sharma AK, Leiby KR, Karagogeos D, Hill B, Humeau L, et al. The characterization, molecular cloning, and expression of a novel hematopoietic cell antigen from CD34+ human bone marrow cells. Blood. 89: 2706-16. PMID 9108388 DOI: 10.1182/Blood.V89.8.2706  0.503
1997 Uchida N, Friera AM, He D, Reitsma MJ, Tsukamoto AS, Weissman IL. Hydroxyurea Can Be Used to Increase Mouse c-kit+Thy-1.1loLin−/loSca-1+ Hematopoietic Cell Number and Frequency in Cell Cycle In Vivo Blood. 90: 4354-4362. DOI: 10.1182/Blood.V90.11.4354.4354_4354_4362  0.626
1997 Uchida N, Friera AM, He D, Reitsma MJ, Tsukamoto AS, Weissman IL. Hydroxyurea Can Be Used to Increase Mouse c-kit+Thy-1.1loLin−/loSca-1+ Hematopoietic Cell Number and Frequency in Cell Cycle In Vivo Blood. 90: 4354-4362. DOI: 10.1182/BLOOD.V90.11.4354.4354_4354_4362  0.573
1997 Uchida N, He D, Friera AM, Reitsma M, Sasaki D, Chen B, Tsukamoto A. The Unexpected G0/G1 Cell Cycle Status of Mobilized Hematopoietic Stem Cells From Peripheral Blood Blood. 89: 465-472. DOI: 10.1182/Blood.V89.2.465  0.561
1996 Sasaki DT, Tichenor EH, Lopez F, Combs J, Uchida N, Smith CR, Stokdijk W, Vardanega M, Buckle AM, Chen B. Development of a clinically applicable high-speed flow cytometer for the isolation of transplantable human hematopoietic stem cells. Journal of Hematotherapy. 4: 503-14. PMID 8846010 DOI: 10.1089/Scd.1.1995.4.503  0.585
1996 Uchida N, Combs J, Chen S, Zanjani E, Hoffman R, Tsukamoto A. Primitive human hematopoietic cells displaying differential efflux of the rhodamine 123 dye have distinct biological activities Blood. 88: 1297-1305. DOI: 10.1182/Blood.V88.4.1297.Bloodjournal8841297  0.464
1995 Morrison SJ, Uchida N, Weissman IL. The biology of hematopoietic stem cells. Annual Review of Cell and Developmental Biology. 11: 35-71. PMID 8689561 DOI: 10.1146/Annurev.Cb.11.110195.000343  0.727
1995 Murray L, Chen B, Galy A, Chen S, Tushinski R, Uchida N, Negrin R, Tricot G, Jagannath S, Vesole D. Enrichment of human hematopoietic stem cell activity in the CD34+Thy- 1+Lin- subpopulation from mobilized peripheral blood Blood. 85: 368-378. DOI: 10.1182/Blood.V85.2.368.Bloodjournal852368  0.565
1994 Uchida N, Aguila HL, Fleming WH, Jerabek L, Weissman IL. Rapid and sustained hematopoietic recovery in lethally irradiated mice transplanted with purified Thy-1.1lo Lin-Sca-1+ hematopoietic stem cells. Blood. 83: 3758-79. PMID 7911343 DOI: 10.1182/Blood.V83.12.3758.Bloodjournal83123758  0.655
1994 Uchida N, Aguila H, Fleming W, Jerabek L, Weissman I. Rapid and sustained hematopoietic recovery in lethally irradiated mice transplanted with purified Thy-1.1lo Lin-Sca-1+ hematopoietic stem cells Blood. 83: 3758-3779. DOI: 10.1182/blood.v83.12.3758.3758  0.493
1993 Fleming WH, Alpern EJ, Uchida N, Ikuta K, Spangrude GJ, Weissman IL. Functional heterogeneity is associated with the cell cycle status of murine hematopoietic stem cells. The Journal of Cell Biology. 122: 897-902. PMID 8349737 DOI: 10.1083/Jcb.122.4.897  0.799
1993 Uchida N, Fleming WH, Alpern EJ, Weissman IL. Heterogeneity of hematopoietic stem cells. Current Opinion in Immunology. 5: 177-84. PMID 8099486 DOI: 10.1016/0952-7915(93)90002-A  0.679
1993 Fleming WH, Alpern EJ, Uchida N, Ikuta K, Weissman IL. Steel factor influences the distribution and activity of murine hematopoietic stem cells in vivo. Proceedings of the National Academy of Sciences of the United States of America. 90: 3760-4. PMID 7682717 DOI: 10.1073/Pnas.90.8.3760  0.756
1992 Ikuta K, Kina T, MacNeil I, Uchida N, Peault B, Chien YH, Weissman IL. Development of gamma delta T-cell subsets from fetal hematopoietic stem cells. Annals of the New York Academy of Sciences. 651: 21-32. PMID 1599125 DOI: 10.1111/J.1749-6632.1992.Tb24590.X  0.725
1992 Ikuta K, Uchida N, Friedman J, Weissman IL. Lymphocyte development from stem cells. Annual Review of Immunology. 10: 759-83. PMID 1375474 DOI: 10.1146/Annurev.Iy.10.040192.003551  0.756
1992 Uchida N, Weissman IL. Searching for hematopoietic stem cells: Evidence that Thy-1.1lo Lin- Sca-1+ cells are the only stem cells in C57BL/Ka-Thy-1.1 bone marrow Journal of Experimental Medicine. 175: 175-184. PMID 1346154 DOI: 10.1084/Jem.175.1.175  0.633
1991 Spangrude GJ, Smith L, Uchida N, Ikuta K, Heimfeld S, Friedman J, Weissman IL. Mouse hematopoietic stem cells. Blood. 78: 1395-402. PMID 1884012 DOI: 10.1182/Blood.V78.6.1395.Bloodjournal7861395  0.823
1991 Spangrude G, Smith L, Uchida N, Ikuta K, Heimfeld S, Friedman J, Weissman I. Mouse hematopoietic stem cells Blood. 78: 1395-1402. DOI: 10.1182/BLOOD.V78.6.1395.BLOODJOURNAL7861395  0.781
1990 Ikuta K, Kina T, MacNeil I, Uchida N, Peault B, Chien YH, Weissman IL. A developmental switch in thymic lymphocyte maturation potential occurs at the level of hematopoietic stem cells. Cell. 62: 863-74. PMID 1975515 DOI: 10.1016/0092-8674(90)90262-D  0.727
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