Judith (Hudi) Licht - Publications

National Institute of Mental Health, Bethesda, MD, United States 

169 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2021 Zee BM, Poels KE, Yao CH, Kawabata KC, Wu G, Duy C, Jacobus WD, Senior E, Endress JE, Jambhekar A, Lovitch SB, Ma J, Dhall A, Harris IS, Blanco MA, ... ... Licht JD, et al. Combined epigenetic and metabolic treatments overcome differentiation blockade in acute myeloid leukemia. Iscience. 24: 102651. PMID 34151238 DOI: 10.1016/j.isci.2021.102651  0.01
2021 Hogg SJ, Motorna O, Cluse LA, Johanson TM, Coughlan HD, Raviram R, Myers RM, Costacurta M, Todorovski I, Pijpers L, Bjelosevic S, Williams T, Huskins SN, Kearney CJ, Devlin JR, ... ... Licht JD, et al. Targeting histone acetylation dynamics and oncogenic transcription by catalytic P300/CBP inhibition. Molecular Cell. 81: 2183-2200.e13. PMID 34019788 DOI: 10.1016/j.molcel.2021.04.015  0.01
2021 Licht JD, Bennett RL. Leveraging epigenetics to enhance the efficacy of immunotherapy. Clinical Epigenetics. 13: 115. PMID 34001289 DOI: 10.1186/s13148-021-01100-x  0.01
2021 Prado G, Kaestner CL, Licht JD, Bennett RL. Targeting epigenetic mechanisms to overcome venetoclax resistance. Biochimica Et Biophysica Acta. Molecular Cell Research. 1868: 119047. PMID 33945824 DOI: 10.1016/j.bbamcr.2021.119047  0.01
2021 Jooß K, Schachner LF, Watson R, Gillespie ZB, Howard SA, Cheek MA, Meiners MJ, Sobh A, Licht JD, Keogh MC, Kelleher NL. Separation and Characterization of Endogenous Nucleosomes by Native Capillary Zone Electrophoresis-Top-Down Mass Spectrometry. Analytical Chemistry. PMID 33749242 DOI: 10.1021/acs.analchem.0c04975  0.01
2021 Shirasaki R, Matthews GM, Gandolfi S, de Matos Simoes R, Buckley DL, Raja Vora J, Sievers QL, Brüggenthies JB, Dashevsky O, Poarch H, Tang H, Bariteau MA, Sheffer M, Hu Y, Downey-Kopyscinski SL, ... ... Licht JD, et al. Functional Genomics Identify Distinct and Overlapping Genes Mediating Resistance to Different Classes of Heterobifunctional Degraders of Oncoproteins. Cell Reports. 34: 108532. PMID 33406420 DOI: 10.1016/j.celrep.2020.108532  0.01
2020 Yusufova N, Kloetgen A, Teater M, Osunsade A, Camarillo JM, Chin CR, Doane AS, Venters BJ, Portillo-Ledesma S, Conway J, Phillip JM, Elemento O, Scott DW, Béguelin W, Licht JD, et al. Histone H1 loss drives lymphoma by disrupting 3D chromatin architecture. Nature. PMID 33299181 DOI: 10.1038/s41586-020-3017-y  0.01
2020 Licht JD. Histone H3 G34 Tail Mutations in Cancer: Actions in and to Alter Chromatin and Gene Expression. Cancer Discovery. 10: 1794-1796. PMID 33262183 DOI: 10.1158/2159-8290.CD-20-1396  0.01
2020 Ordonez R, Kulis M, Russinol N, Chapaprieta V, Carrasco-Leon A, Garcia-Torre B, Charampopoulou S, Clot G, Beekman R, Meydan C, Duran-Ferrer M, Verdaguer-Dot N, Vilarrasa-Blasi R, Soler-Vila P, Garate L, ... ... Licht JD, et al. Chromatin activation as a unifying principle underlying pathogenic mechanisms in multiple myeloma. Genome Research. PMID 32820006 DOI: 10.1101/Gr.265520.120  0.01
2020 Longo J, Smirnov P, Li Z, Branchard E, van Leeuwen JE, Licht JD, Haibe-Kains B, Andrews DW, Keats JJ, Pugh TJ, Trudel S, Penn LZ. The mevalonate pathway is an actionable vulnerability of t(4;14)-positive multiple myeloma. Leukemia. PMID 32665698 DOI: 10.1038/S41375-020-0962-2  0.01
2020 Licht JD. Oncogenesis by E2A-PBX1 in ALL: RUNX and more. Blood. 136: 3-4. PMID 32614960 DOI: 10.1182/blood.2020005879  0.01
2020 Tamashunas AC, Tocco VJ, Matthews J, Zhang Q, Atanasova KR, Paschall L, Pathak S, Ratnayake R, Stephens AD, Luesch H, Licht JD, Lele TP. High-throughput gene screen reveals modulators of nuclear shape. Molecular Biology of the Cell. mbcE19090520. PMID 32320319 DOI: 10.1091/Mbc.E19-09-0520  0.01
2020 Sheng Y, Yu C, Liu Y, Hu C, Ma R, Lu X, Ji P, Chen J, Mizukawa B, Huang Y, Licht JD, Qian Z. FOXM1 regulates leukemia stem cell quiescence and survival in MLL-rearranged AML. Nature Communications. 11: 928. PMID 32066721 DOI: 10.1038/s41467-020-14590-9  0.01
2020 Cheong CM, Mrozik KM, Hewett DR, Bell E, Panagopoulos V, Noll JE, Licht JD, Gronthos S, Zannettino ACW, Vandyke K. Twist-1 is upregulated by NSD2 and contributes to tumour dissemination and an epithelial-mesenchymal transition-like gene expression signature in t(4;14)-positive multiple myeloma. Cancer Letters. PMID 32014459 DOI: 10.1016/j.canlet.2020.01.040  0.01
2019 Gonçalves J, Emmons MF, Faião-Flores F, Aplin AE, Harbour JW, Licht JD, Wink MR, Smalley KSM. Decitabine limits escape from MEK inhibition in uveal melanoma. Pigment Cell & Melanoma Research. PMID 31758842 DOI: 10.1111/Pcmr.12849  0.01
2019 Jiang Y, Gao R, Cao C, Forbes L, Li J, Freeberg S, Fredenburg KM, Justice JM, Silver NL, Wu L, Varma S, West R, Licht JD, Zajac-Kaye M, Kentsis A, et al. MYB-activated models for testing therapeutic agents in adenoid cystic carcinoma. Oral Oncology. 98: 147-155. PMID 31606723 DOI: 10.1016/J.Oraloncology.2019.09.005  0.01
2019 Bennett RL, Bele A, Small EC, Will CM, Nabet B, Oyer JA, Huang X, Ghosh RP, Grzybowski AT, Yu T, Zhang Q, Riva A, Lele TP, Schatz GC, Kelleher NL, ... Licht JD, et al. A Mutation in Histone H2B Represents a New Class of Oncogenic Driver. Cancer Discovery. PMID 31337617 DOI: 10.1158/2159-8290.Cd-19-0393  0.01
2019 Vaquero M, Cuesta S, Anerillas C, Altés G, Ribera J, Basson MA, Licht JD, Egea J, Encinas M. Sprouty1 Controls Genitourinary Development via its N-Terminal Tyrosine. Journal of the American Society of Nephrology : Jasn. PMID 31300484 DOI: 10.1681/ASN.2018111085  0.01
2019 Huang X, LeDuc RD, Fornelli L, Schunter AJ, Bennett RL, Kelleher NL, Licht JD. Defining the NSD2 interactome: PARP1 PARylation reduces NSD2 histone methyltransferase activity and impedes chromatin binding. The Journal of Biological Chemistry. PMID 31248990 DOI: 10.1074/Jbc.Ra118.006159  0.01
2019 Faião-Flores F, Emmons MF, Durante MA, Kinose F, Saha B, Fang B, Koomen JM, Chellappan SP, Maria-Engler SS, Rix U, Licht JD, Harbour JW, Smalley KSM. HDAC inhibition enhances the in vivo efficacy of MEK inhibitor therapy in uveal melanoma. Clinical Cancer Research : An Official Journal of the American Association For Cancer Research. PMID 31227503 DOI: 10.1158/1078-0432.Ccr-18-3382  0.01
2019 Emmons MF, Faião-Flores F, Sharma R, Thapa R, Messina JL, Becker JC, Schadendorf D, Seto E, Sondak VK, Koomen JM, Chen YA, Lau EK, Wan L, Licht JD, Smalley KSM. HDAC8 regulates a stress response pathway in melanoma to mediate escape from BRAF inhibitor therapy. Cancer Research. PMID 30987999 DOI: 10.1158/0008-5472.Can-19-0040  0.01
2019 Alakoski T, Ulvila J, Yrjölä R, Vainio L, Magga J, Szabo Z, Licht JD, Kerkelä R. Inhibition of cardiomyocyte Sprouty1 protects from cardiac ischemia-reperfusion injury. Basic Research in Cardiology. 114: 7. PMID 30635790 DOI: 10.1007/s00395-018-0713-y  0.01
2019 Emmons M, Flores F, Koomen J, Seto E, Messina J, Lau E, Licht J, Smalley K. Abstract 3800: HDAC8 regulates plasticity and escape from therapy in BRAF mutant melanoma Cancer Research. DOI: 10.1158/1538-7445.Sabcs18-3800  0.01
2019 Faiao-Flores F, Emmons M, Durante M, Saha B, Fang B, Koomen J, Chellappan S, Maria-Engler S, Licht J, Harbour W, Smalley K. Abstract 378: HDAC inhibition enhances MEK antagonist therapy in uveal melanoma through combined blockade of YAP, AKT and RTK signaling Cancer Research. 79: 378-378. DOI: 10.1158/1538-7445.Sabcs18-378  0.01
2018 Alzrigat M, Jernberg-Wiklund H, Licht JD. Targeting EZH2 in Multiple Myeloma-Multifaceted Anti-Tumor Activity. Epigenomes. 2. PMID 30761216 DOI: 10.3390/epigenomes2030016  0.01
2018 Kim J, Lee Y, Lu X, Song B, Fong KW, Cao Q, Licht JD, Zhao JC, Yu J. Polycomb- and Methylation-Independent Roles of EZH2 as a Transcription Activator. Cell Reports. 25: 2808-2820.e4. PMID 30517868 DOI: 10.1016/J.Celrep.2018.11.035  0.01
2018 Swaroop A, Oyer JA, Will CM, Huang X, Yu W, Troche C, Bulic M, Durham BH, Wen QJ, Crispino JD, MacKerell AD, Bennett RL, Kelleher NL, Licht JD. An activating mutation of the NSD2 histone methyltransferase drives oncogenic reprogramming in acute lymphocytic leukemia. Oncogene. PMID 30171259 DOI: 10.1038/S41388-018-0474-Y  0.01
2018 Licht JD. DISORDERED HISTONE METHYLATION IN HEMATOLOGICAL MALIGNANCIES THE CASE OF UTX/KDM6A. Transactions of the American Clinical and Climatological Association. 129: 24-36. PMID 30166694  0.01
2018 Melo-Cardenas J, Xu Y, Wei J, Tan C, Kong S, Gao B, Montauti E, Kirsammer G, Licht JD, Yu J, Ji P, Crispino JD, Fang D. USP22 deficiency leads to myeloid leukemia upon oncogenic Kras activation through a PU.1 dependent mechanism. Blood. PMID 29844011 DOI: 10.1182/Blood-2017-10-811760  0.01
2018 Luo H, Wang F, Zha J, Li H, Yan B, Du Q, Yang F, Sobh A, Vulpe C, Drusbosky L, Cogle C, Chepelev I, Xu B, Nimer SD, Licht J, et al. CTCF boundary remodels chromatin domain and drives aberrant HOX gene transcription in acute myeloid leukemia. Blood. PMID 29760161 DOI: 10.1182/Blood-2017-11-814319  0.01
2018 Fantini D, Glaser AP, Rimar KJ, Wang Y, Schipma M, Varghese N, Rademaker A, Behdad A, Yellapa A, Yu Y, Sze CC, Wang L, Zhao Z, Crawford SE, Hu D, Licht JD, et al. A Carcinogen-induced mouse model recapitulates the molecular alterations of human muscle invasive bladder cancer. Oncogene. PMID 29367767 DOI: 10.1038/S41388-017-0099-6  0.01
2018 Venugopal K, Dupéré-Richer D, Licht J, Guryanova O. Abstract 343: Targeting DNA replication as a therapeutic strategy for acute myeloid leukemia with DNMT3A mutations Cancer Research. 78: 343-343. DOI: 10.1158/1538-7445.Am2018-343  0.01
2017 Licht JD. SETD2: a complex role in blood malignancy. Blood. 130: 2576-2578. PMID 29242204 DOI: 10.1182/blood-2017-10-811927  0.01
2017 Yang X, Gong Y, He Q, Licht JD, Liaw L, Friesel RE. Loss of Spry1 attenuates vascular smooth muscle proliferation by impairing mitogen-mediated changes in cell cycle regulatory circuits. Journal of Cellular Biochemistry. PMID 29105817 DOI: 10.1002/Jcb.26486  0.01
2017 Ezponda T, Dupéré-Richer D, Will CM, Small EC, Varghese N, Patel T, Nabet B, Popovic R, Oyer J, Bulic M, Zheng Y, Huang X, Shah MY, Maji S, Riva A, ... Licht JD, et al. UTX/KDM6A Loss Enhances the Malignant Phenotype of Multiple Myeloma and Sensitizes Cells to EZH2 inhibition. Cell Reports. 21: 628-640. PMID 29045832 DOI: 10.1016/J.Celrep.2017.09.078  0.01
2017 Bennett RL, Licht JD. Targeting Epigenetics in Cancer. Annual Review of Pharmacology and Toxicology. PMID 28992434 DOI: 10.1146/annurev-pharmtox-010716-105106  0.01
2017 Tocco VJ, Li Y, Christopher KG, Matthews JH, Aggarwal V, Paschall L, Luesch H, Licht JD, Dickinson RB, Lele TP. The nucleus is irreversibly shaped by motion of cell boundaries in cancer and non-cancer cells. Journal of Cellular Physiology. PMID 28542912 DOI: 10.1002/Jcp.26031  0.01
2017 Dupéré-Richer D, Licht JD. Epigenetic regulatory mutations and epigenetic therapy for multiple myeloma. Current Opinion in Hematology. 24: 336-344. PMID 28441149 DOI: 10.1097/MOH.0000000000000358  0.01
2017 Bennett RL, Swaroop A, Troche C, Licht JD. The Role of Nuclear Receptor-Binding SET Domain Family Histone Lysine Methyltransferases in Cancer. Cold Spring Harbor Perspectives in Medicine. PMID 28193767 DOI: 10.1101/cshperspect.a026708  0.01
2017 Guryanova OA, Licht JD. FQI1: a transcription-methylation switch for cancer. Oncotarget. 8: 12536-12537. PMID 28177910 DOI: 10.18632/oncotarget.15087  0.01
2017 Mahajan N, Wu HJ, Bennett RL, Troche C, Licht JD, Weber JD, Maggi LB, Tomasson MH. Sabotaging of the oxidative stress response by an oncogenic noncoding RNA. Faseb Journal : Official Publication of the Federation of American Societies For Experimental Biology. 31: 482-490. PMID 28148777 DOI: 10.1096/Fj.201600654R  0.01
2016 Schauwecker SM, Kim JJ, Licht JD, Clevenger CV. Histone H1 and Chromosomal Protein HMGN2 Regulate Prolactin-Induced STAT5 Transcription Factor Recruitment and Function in Breast Cancer Cells. The Journal of Biological Chemistry. PMID 28035005 DOI: 10.1074/Jbc.M116.764233  0.01
2016 Arcipowski KM, Bulic M, Gurbuxani S, Licht JD. Loss of Mll3 Catalytic Function Promotes Aberrant Myelopoiesis. Plos One. 11: e0162515. PMID 27610619 DOI: 10.1371/Journal.Pone.0162515  0.01
2016 Béguelin W, Teater M, Gearhart MD, Calvo Fernández MT, Goldstein RL, Cárdenas MG, Hatzi K, Rosen M, Shen H, Corcoran CM, Hamline MY, Gascoyne RD, Levine RL, Abdel-Wahab O, Licht JD, et al. EZH2 and BCL6 Cooperate to Assemble CBX8-BCOR Complex to Repress Bivalent Promoters, Mediate Germinal Center Formation and Lymphomagenesis. Cancer Cell. 30: 197-213. PMID 27505670 DOI: 10.1016/J.Ccell.2016.07.006  0.01
2016 Dupéré-Richer D, Kinal M, Pettersson F, Emond A, Calvo-Vidal MN, Nichol JN, Guilbert C, Plourde D, Klein Oros K, Nielsen TH, Ezponda T, Licht JD, Johnson NA, Assouline S, Cerchietti L, et al. Increased protein processing gene signature in HDACi-resistant cells predicts response to proteasome inhibitors. Leukemia & Lymphoma. 1-4. PMID 27185211 DOI: 10.1080/10428194.2016.1180684  0.44
2016 Shah MY, Martinez-Garcia E, Phillip JM, Chambliss AB, Popovic R, Ezponda T, Small EC, Will C, Phillip MP, Neri P, Bahlis NJ, Wirtz D, Licht JD. MMSET/WHSC1 enhances DNA damage repair leading to an increase in resistance to chemotherapeutic agents. Oncogene. PMID 27109101 DOI: 10.1038/Onc.2016.116  0.44
2015 McConnell MJ, Durand L, Langley E, Coste-Sarguet L, Zelent A, Chomienne C, Kouzarides T, Licht JD, Guidez F. Post transcriptional control of the epigenetic stem cell regulator PLZF by sirtuin and HDAC deacetylases. Epigenetics & Chromatin. 8: 38. PMID 26405459 DOI: 10.1186/S13072-015-0030-8  0.44
2015 Licht JD. DNA Methylation Inhibitors in Cancer Therapy: The Immunity Dimension. Cell. 162: 938-9. PMID 26317460 DOI: 10.1016/j.cell.2015.08.005  0.01
2015 Nabet B, Ó Broin P, Reyes JM, Shieh K, Lin CY, Will CM, Popovic R, Ezponda T, Bradner JE, Golden AA, Licht JD. Deregulation of the Ras-Erk Signaling Axis Modulates the Enhancer Landscape. Cell Reports. 12: 1300-13. PMID 26279576 DOI: 10.1016/J.Celrep.2015.06.078  0.44
2015 Zheng Y, Fornelli L, Compton PD, Sharma S, Canterbury J, Mullen C, Zabrouskov V, Fellers RT, Thomas PM, Licht JD, Senko MW, Kelleher NL. Unabridged Analysis of Human Histone H3 by Differential Top-Down Mass Spectrometry Reveals Hypermethylated Proteoforms from MMSET/NSD2 Overexpression. Molecular & Cellular Proteomics : McP. PMID 26272979 DOI: 10.1074/Mcp.M115.053819  0.44
2015 Kumar K, Raza SS, Knab LM, Chow CR, Kwok B, Bentrem DJ, Popovic R, Ebine K, Licht JD, Munshi HG. GLI2-dependent c-MYC upregulation mediates resistance of pancreatic cancer cells to the BET bromodomain inhibitor JQ1. Scientific Reports. 5: 9489. PMID 25807524 DOI: 10.1038/Srep09489  0.44
2015 Zhou Z, Gao J, Popovic R, Wolniak K, Parimi V, Winter JN, Licht JD, Chen YH. Strong expression of EZH2 and accumulation of trimethylated H3K27 in diffuse large B-cell lymphoma independent of cell of origin and EZH2 codon 641 mutation. Leukemia & Lymphoma. 1-7. PMID 25651430 DOI: 10.3109/10428194.2015.1006220  0.01
2015 Saloura V, Cho HS, Kiyotani K, Alachkar H, Zuo Z, Nakakido M, Tsunoda T, Seiwert T, Lingen M, Licht J, Nakamura Y, Hamamoto R. WHSC1 promotes oncogenesis through regulation of NIMA-related kinase-7 in squamous cell carcinoma of the head and neck. Molecular Cancer Research : McR. 13: 293-304. PMID 25280969 DOI: 10.1158/1541-7786.Mcr-14-0292-T  0.01
2015 Bainer R, Yui Y, Mumenthaler S, Mallick P, Liu L, Wu H, Podlaha O, Michor F, Liphardt J, Licht J, Weaver V. Abstract PR09: Extracellular stiffness cues drive spatial reorganization of the genome to globally constrain RNA abundance Cancer Research. 75. DOI: 10.1158/1538-7445.Compsysbio-Pr09  0.01
2014 Rampal R, Alkalin A, Madzo J, Vasanthakumar A, Pronier E, Patel J, Li Y, Ahn J, Abdel-Wahab O, Shih A, Lu C, Ward PS, Tsai JJ, Hricik T, Tosello V, ... Licht JD, et al. DNA hydroxymethylation profiling reveals that WT1 mutations result in loss of TET2 function in acute myeloid leukemia. Cell Reports. 9: 1841-55. PMID 25482556 DOI: 10.1016/J.Celrep.2014.11.004  0.44
2014 Popovic R, Martinez-Garcia E, Giannopoulou EG, Zhang Q, Zhang Q, Ezponda T, Shah MY, Zheng Y, Will CM, Small EC, Hua Y, Bulic M, Jiang Y, Carrara M, Calogero RA, ... Licht JD, et al. Histone methyltransferase MMSET/NSD2 alters EZH2 binding and reprograms the myeloma epigenome through global and focal changes in H3K36 and H3K27 methylation. Plos Genetics. 10: e1004566. PMID 25188243 DOI: 10.1371/Journal.Pgen.1004566  0.44
2014 Ezponda T, Licht JD. Molecular pathways: deregulation of histone h3 lysine 27 methylation in cancer-different paths, same destination. Clinical Cancer Research : An Official Journal of the American Association For Cancer Research. 20: 5001-8. PMID 24987060 DOI: 10.1158/1078-0432.CCR-13-2499  0.01
2014 Small EC, Xi L, Wang JP, Widom J, Licht JD. Single-cell nucleosome mapping reveals the molecular basis of gene expression heterogeneity. Proceedings of the National Academy of Sciences of the United States of America. 111: E2462-71. PMID 24889621 DOI: 10.1073/Pnas.1400517111  0.44
2014 Yoon JH, Kim MY, Koh DI, Licht JD, Kim K, Hur MW. Promyelocytic leukemia zinc finger-retinoic acid receptor - (PLZF-RAR-), an oncogenic transcriptional repressor of cyclin-dependent kinase inhibitor 1A (p21WAF/CDKN1A) and tumor protein p53 (TP53) genes Won-Il Choi Journal of Biological Chemistry. 289: 18641-18656. PMID 24821728 DOI: 10.1074/jbc.M113.538777  0.44
2014 Licht JD, Shortt J, Johnstone R. From anecdote to targeted therapy: the curious case of thalidomide in multiple myeloma. Cancer Cell. 25: 9-11. PMID 24434206 DOI: 10.1016/j.ccr.2013.12.019  0.01
2014 Oyer JA, Huang X, Zheng Y, Shim J, Ezponda T, Carpenter Z, Allegretta M, Okot-Kotber CI, Patel JP, Melnick A, Levine RL, Ferrando A, Mackerell AD, Kelleher NL, Licht JD, et al. Point mutation E1099K in MMSET/NSD2 enhances its methyltranferase activity and leads to altered global chromatin methylation in lymphoid malignancies. Leukemia. 28: 198-201. PMID 23823660 DOI: 10.1038/Leu.2013.204  0.44
2014 Beguelin W, Teater M, Popovic R, Jiang Y, Cerchietti L, Shaknovich R, Gascoyne R, Levine R, Abdel-Wahab O, Licht J, Elemento O, Melnick AM. Abstract SY09-03: How deregulation of histone methyltransferases drive malignant transformation of B-cells Cancer Research. 74. DOI: 10.1158/1538-7445.Am2014-Sy09-03  0.01
2014 Bainer R, Yui Y, Mumenthaler S, Mallick P, Podlaha O, Michor F, Liphardt J, Licht J, Weaver V. Abstract 2344: 3D extracellular stiffness cues drive localized changes in gene expression Cancer Research. 74: 2344-2344. DOI: 10.1158/1538-7445.Am2014-2344  0.01
2013 Kuracha MR, Siefker E, Licht JD, Govindarajan V. Spry1 and Spry2 are necessary for eyelid closure Developmental Biology. 383: 227-238. PMID 24055172 DOI: 10.1016/j.ydbio.2013.09.014  0.44
2013 Frankfurt O, Licht JD. Ponatinib--a step forward in overcoming resistance in chronic myeloid leukemia. Clinical Cancer Research : An Official Journal of the American Association For Cancer Research. 19: 5828-34. PMID 23935038 DOI: 10.1158/1078-0432.CCR-13-0258  0.01
2013 Mehrotra S, Sharma B, Joshi S, Kroczynska B, Majchrzak B, Stein BL, McMahon B, Altman JK, Licht JD, Baker DP, Eklund EA, Wickrema A, Verma A, Fish EN, Platanias LC. Essential role for the Mnk pathway in the inhibitory effects of type I interferons on myeloproliferative neoplasm (MPN) precursors. The Journal of Biological Chemistry. 288: 23814-22. PMID 23814052 DOI: 10.1074/Jbc.M113.476192  0.44
2013 Sullivan LB, Martinez-Garcia E, Nguyen H, Mullen AR, Dufour E, Sudarshan S, Licht JD, Deberardinis RJ, Chandel NS. The proto-oncometabolite fumarate binds glutathione to amplify ROS-dependent signaling. Molecular Cell. 51: 236-48. PMID 23747014 DOI: 10.1016/J.Molcel.2013.05.003  0.01
2013 Béguelin W, Popovic R, Teater M, Jiang Y, Bunting KL, Rosen M, Shen H, Yang SN, Wang L, Ezponda T, Martinez-Garcia E, Zhang H, Zheng Y, Verma SK, McCabe MT, ... Licht JD, et al. EZH2 is required for germinal center formation and somatic EZH2 mutations promote lymphoid transformation. Cancer Cell. 23: 677-92. PMID 23680150 DOI: 10.1016/J.Ccr.2013.04.011  0.44
2013 Fournier C, Bedlack B, Hardiman O, Heiman-Patterson T, Gutmann L, Bromberg M, Ostrow L, Carter G, Kabashi E, Bertorini T, Mozaffar T, Andersen P, Dietz J, Gamez J, ... Licht J, et al. ALS Untangled No. 20: the Deanna protocol. Amyotrophic Lateral Sclerosis & Frontotemporal Degeneration. 14: 319-23. PMID 23638638 DOI: 10.3109/21678421.2013.788405  0.01
2013 Agus DB, Alexander JF, Arap W, Ashili S, Aslan JE, Austin RH, Backman V, Bethel KJ, Bonneau R, Chen WC, Chen-Tanyolac C, Choi NC, Curley SA, Dallas M, ... Licht JD, et al. A physical sciences network characterization of non-tumorigenic and metastatic cells. Scientific Reports. 3: 1449. PMID 23618955 DOI: 10.1038/Srep01449  0.44
2013 Popovic R, Shah MY, Licht JD. Epigenetic therapy of hematological malignancies: where are we now? Therapeutic Advances in Hematology. 4: 81-91. PMID 23610616 DOI: 10.1177/2040620712466864  0.01
2013 Petruccelli LA, Pettersson F, Del Rincón SV, Guilbert C, Licht JD, Miller WH. Expression of leukemia-associated fusion proteins increases sensitivity to histone deacetylase inhibitor-induced DNA damage and apoptosis. Molecular Cancer Therapeutics. 12: 1591-604. PMID 23536727 DOI: 10.1158/1535-7163.Mct-12-1039  0.44
2013 Sena LA, Li S, Jairaman A, Prakriya M, Ezponda T, Hildeman DA, Wang CR, Schumacker PT, Licht JD, Perlman H, Bryce PJ, Chandel NS. Mitochondria are required for antigen-specific T cell activation through reactive oxygen species signaling. Immunity. 38: 225-36. PMID 23415911 DOI: 10.1016/J.Immuni.2012.10.020  0.44
2013 Min DJ, Ezponda T, Kim MK, Will CM, Martinez-Garcia E, Popovic R, Basrur V, Elenitoba-Johnson KS, Licht JD. MMSET stimulates myeloma cell growth through microRNA-mediated modulation of c-MYC Leukemia. 27: 686-694. PMID 22972034 DOI: 10.1182/Blood.V118.21.469.469  0.44
2013 Ezponda T, Popovic R, Shah MY, Martinez-Garcia E, Zheng Y, Min DJ, Will C, Neri A, Kelleher NL, Yu J, Licht JD. The histone methyltransferase MMSET/WHSC1 activates TWIST1 to promote an epithelial-mesenchymal transition and invasive properties of prostate cancer. Oncogene. 32: 2882-90. PMID 22797064 DOI: 10.1038/Onc.2012.297  0.44
2012 Collins S, Waickman A, Basson A, Kupfer A, Licht JD, Horton MR, Powell JD. Regulation of CD4+ and CD8+ Effector Responses by Sprouty-1 Plos One. 7. PMID 23166773 DOI: 10.1371/Journal.Pone.0049801  0.44
2012 Sharma B, Joshi S, Sassano A, Majchrzak B, Kaur S, Aggarwal P, Nabet B, Bulic M, Stein BL, McMahon B, Baker DP, Fukunaga R, Altman JK, Licht JD, Fish EN, et al. Sprouty proteins are negative regulators of interferon (IFN) signaling and IFN-inducible biological responses. The Journal of Biological Chemistry. 287: 42352-60. PMID 23074222 DOI: 10.1074/Jbc.M112.400721  0.44
2012 Khan I, Altman JK, Licht JD. New strategies in acute myeloid leukemia: redefining prognostic markers to guide therapy. Clinical Cancer Research : An Official Journal of the American Association For Cancer Research. 18: 5163-71. PMID 22893630 DOI: 10.1158/1078-0432.CCR-12-0313  0.44
2012 Zheng Y, Sweet SM, Popovic R, Martinez-Garcia E, Tipton JD, Thomas PM, Licht JD, Kelleher NL. Total kinetic analysis reveals how combinatorial methylation patterns are established on lysines 27 and 36 of histone H3. Proceedings of the National Academy of Sciences of the United States of America. 109: 13549-54. PMID 22869745 DOI: 10.1073/Pnas.1205707109  0.44
2012 Kentsis A, Reed C, Rice KL, Sanda T, Rodig SJ, Tholouli E, Christie A, Valk PJ, Delwel R, Ngo V, Kutok JL, Dahlberg SE, Moreau LA, Byers RJ, Christensen JG, ... Licht JD, et al. Autocrine activation of the MET receptor tyrosine kinase in acute myeloid leukemia. Nature Medicine. 18: 1118-22. PMID 22683780 DOI: 10.1038/Nm.2819  0.44
2012 Popovic R, Licht JD. Emerging epigenetic targets and therapies in cancer medicine. Cancer Discovery. 2: 405-13. PMID 22588878 DOI: 10.1158/2159-8290.Cd-12-0076  0.44
2012 Sathyanarayana P, Dev A, Pradeep A, Ufkin M, Licht JD, Wojchowski DM. Spry1 as a novel regulator of erythropoiesis, EPO/EPOR target, and suppressor of JAK2. Blood. 119: 5522-31. PMID 22508938 DOI: 10.1182/Blood-2011-11-392571  0.44
2012 Hwangpo TA, Jordan JD, Premsrirut PK, Jayamaran G, Licht JD, Iyengar R, Neves SR. G Protein-regulated inducer of neurite outgrowth (GRIN) modulates Sprouty protein repression of mitogen-activated protein kinase (MAPK) activation by growth factor stimulation. The Journal of Biological Chemistry. 287: 13674-85. PMID 22383529 DOI: 10.1074/Jbc.M111.320705  0.44
2012 Biyashev D, Veliceasa D, Topczewski J, Topczewska JM, Mizgirev I, Vinokour E, Reddi AL, Licht JD, Revskoy SY, Volpert OV. miR-27b controls venous specification and tip cell fate. Blood. 119: 2679-87. PMID 22207734 DOI: 10.1182/Blood-2011-07-370635  0.44
2011 Tefferi A, Abdel-Wahab O, Cervantes F, Crispino JD, Finazzi G, Girodon F, Gisslinger H, Gotlib J, Kiladjian JJ, Levine RL, Licht JD, Mullally A, Odenike O, Pardanani A, Silver RT, et al. Mutations with epigenetic effects in myeloproliferative neoplasms and recent progress in treatment: Proceedings from the 5th International Post-ASH Symposium. Blood Cancer Journal. 1: e7. PMID 23471017 DOI: 10.1038/bcj.2011.4  0.44
2011 Rice KL, Lin X, Wolniak K, Ebert BL, Berkofsky-Fessler W, Buzzai M, Sun Y, Xi C, Elkin P, Levine R, Golub T, Gilliland DG, Crispino JD, Licht JD, Zhang W. Analysis of genomic aberrations and gene expression profiling identifies novel lesions and pathways in myeloproliferative neoplasms. Blood Cancer Journal. 1: e40. PMID 22829077 DOI: 10.1038/Bcj.2011.39  0.44
2011 Kuracha MR, Burgess D, Siefker E, Cooper JT, Licht JD, Robinson ML, Govindarajan V. Spry1 and Spry2 are necessary for lens vesicle separation and corneal differentiation. Investigative Ophthalmology & Visual Science. 52: 6887-97. PMID 21743007 DOI: 10.1167/Iovs.11-7531  0.44
2011 Shah MY, Licht JD. DNMT3A mutations in acute myeloid leukemia. Nature Genetics. 43: 289-90. PMID 21445072 DOI: 10.1038/ng0411-289  0.01
2011 Popovic R, Licht JD. MEK and MAF in myeloma therapy. Blood. 117: 2300-2. PMID 21350059 DOI: 10.1182/Blood-2011-01-327262  0.44
2011 Pettersson F, Miller WH, Nervi C, Gronemeyer HJ, Licht J, Tallman MS, Waxman S. The 12th international conference on differentiation therapy: targeting the aberrant growth, differentiation and cell death programs of cancer cells. Cell Death and Differentiation. 18: 1231-3. PMID 21212795 DOI: 10.1038/Cdd.2010.173  0.44
2011 Martinez-Garcia E, Popovic R, Min DJ, Sweet SM, Thomas PM, Zamdborg L, Heffner A, Will C, Lamy L, Staudt LM, Levens DL, Kelleher NL, Licht JD. The MMSET histone methyl transferase switches global histone methylation and alters gene expression in t(4;14) multiple myeloma cells. Blood. 117: 211-20. PMID 20974671 DOI: 10.1182/Blood-2010-07-298349  0.44
2011 Kim MK, Min DJ, Rabin M, Licht JD. Functional characterization of Wilms tumor-suppressor WTX and tumor-associated mutants. Oncogene. 30: 832-42. PMID 20956941 DOI: 10.1038/onc.2010.452  0.44
2010 Min DJ, Licht JD. Partners in crime: Genes within an amplicon collude to globally deregulate chromatin in lymphoma. Cancer Cell. 18: 539-41. PMID 21156276 DOI: 10.1016/j.ccr.2010.11.032  0.01
2010 Lagha M, Sato T, Regnault B, Cumano A, Zuniga A, Licht J, Relaix F, Buckingham M. Transcriptome analyses based on genetic screens for Pax3 myogenic targets in the mouse embryo. Bmc Genomics. 11: 696. PMID 21143873 DOI: 10.1186/1471-2164-11-696  0.01
2010 Figueroa ME, Abdel-Wahab O, Lu C, Ward PS, Patel J, Shih A, Li Y, Bhagwat N, Vasanthakumar A, Fernandez HF, Tallman MS, Sun Z, Wolniak K, Peeters JK, Liu W, ... Licht JD, et al. Leukemic IDH1 and IDH2 mutations result in a hypermethylation phenotype, disrupt TET2 function, and impair hematopoietic differentiation. Cancer Cell. 18: 553-67. PMID 21130701 DOI: 10.1016/J.Ccr.2010.11.015  0.44
2010 Akbulut S, Reddi AL, Aggarwal P, Ambardekar C, Canciani B, Kim MK, Hix L, Vilimas T, Mason J, Basson MA, Lovatt M, Powell J, Collins S, Quatela S, Phillips M, Licht JD, et al. Sprouty proteins inhibit receptor-mediated activation of phosphatidylinositol-specific phospholipase C. Molecular Biology of the Cell. 21: 3487-96. PMID 20719962 DOI: 10.1091/Mbc.E10-02-0123  0.01
2010 Berkofsky-Fessler W, Buzzai M, Kim MK, Fruchtman S, Najfeld V, Min DJ, Costa FF, Bischof JM, Soares MB, McConnell MJ, Zhang W, Levine R, Gilliland DG, Calogero R, Licht JD. Transcriptional profiling of polycythemia vera identifies gene expression patterns both dependent and independent from the action of JAK2V617F. Clinical Cancer Research : An Official Journal of the American Association For Cancer Research. 16: 4339-52. PMID 20601445 DOI: 10.1158/1078-0432.Ccr-10-1092  0.44
2010 Gilbert PM, Mouw JK, Unger MA, Lakins JN, Gbegnon MK, Clemmer VB, Benezra M, Licht JD, Boudreau NJ, Tsai KK, Welm AL, Feldman MD, Weber BL, Weaver VM. HOXA9 regulates BRCA1 expression to modulate human breast tumor phenotype. The Journal of Clinical Investigation. 120: 1535-50. PMID 20389018 DOI: 10.1172/Jci39534  0.44
2010 Shea KL, Xiang W, LaPorta VS, Licht JD, Keller C, Basson MA, Brack AS. Sprouty1 regulates reversible quiescence of a self-renewing adult muscle stem cell pool during regeneration. Cell Stem Cell. 6: 117-29. PMID 20144785 DOI: 10.1016/J.Stem.2009.12.015  0.01
2010 Martinez-Garcia E, Licht JD. Deregulation of H3K27 methylation in cancer. Nature Genetics. 42: 100-1. PMID 20104248 DOI: 10.1038/ng0210-100  0.01
2010 Michos O, Cebrian C, Hyink D, Grieshammer U, Williams L, D'Agati V, Licht JD, Martin GR, Costantini F. Kidney development in the absence of Gdnf and Spry1 requires Fgf10. Plos Genetics. 6: e1000809. PMID 20084103 DOI: 10.1371/Journal.Pgen.1000809  0.44
2009 Rice KL, Hormaeche I, Doulatov S, Flatow JM, Grimwade D, Mills KI, Leiva M, Ablain J, Ambardekar C, McConnell MJ, Dick JE, Licht JD. Comprehensive genomic screens identify a role for PLZF-RARalpha as a positive regulator of cell proliferation via direct regulation of c-MYC. Blood. 114: 5499-511. PMID 19855079 DOI: 10.1182/blood-2009-03-206524  0.44
2009 Doulatov S, Notta F, Rice KL, Howell L, Zelent A, Licht JD, Dick JE. PLZF is a regulator of homeostatic and cytokine-induced myeloid development. Genes & Development. 23: 2076-87. PMID 19723763 DOI: 10.1101/gad.1788109  0.01
2009 Chi X, Michos O, Shakya R, Riccio P, Enomoto H, Licht JD, Asai N, Takahashi M, Ohgami N, Kato M, Mendelsohn C, Costantini F. Ret-dependent cell rearrangements in the Wolffian duct epithelium initiate ureteric bud morphogenesis. Developmental Cell. 17: 199-209. PMID 19686681 DOI: 10.1016/J.Devcel.2009.07.013  0.44
2009 Figueroa ME, Skrabanek L, Li Y, Jiemjit A, Fandy TE, Paietta E, Fernandez H, Tallman MS, Greally JM, Carraway H, Licht JD, Gore SD, Melnick A. MDS and secondary AML display unique patterns and abundance of aberrant DNA methylation. Blood. 114: 3448-58. PMID 19652201 DOI: 10.1182/Blood-2009-01-200519  0.44
2009 Kim MK, McGarry TJ, O Broin P, Flatow JM, Golden AA, Licht JD. An integrated genome screen identifies the Wnt signaling pathway as a major target of WT1. Proceedings of the National Academy of Sciences of the United States of America. 106: 11154-9. PMID 19549856 DOI: 10.1073/Pnas.0901591106  0.44
2009 Fandy TE, Herman JG, Kerns P, Jiemjit A, Sugar EA, Choi SH, Yang AS, Aucott T, Dauses T, Odchimar-Reissig R, Licht J, McConnell MJ, Nasrallah C, Kim MK, Zhang W, et al. Early epigenetic changes and DNA damage do not predict clinical response in an overlapping schedule of 5-azacytidine and entinostat in patients with myeloid malignancies. Blood. 114: 2764-73. PMID 19546476 DOI: 10.1182/Blood-2009-02-203547  0.44
2009 Xu D, Holko M, Sadler AJ, Scott B, Higashiyama S, Berkofsky-Fessler W, McConnell MJ, Pandolfi PP, Licht JD, Williams BR. Promyelocytic leukemia zinc finger protein regulates interferon-mediated innate immunity. Immunity. 30: 802-16. PMID 19523849 DOI: 10.1016/J.Immuni.2009.04.013  0.44
2009 Wen Q, Leung C, Huang Z, Small S, Reddi AL, Licht JD, Crispino JD. Survivin is not required for the endomitotic cell cycle of megakaryocytes. Blood. 114: 153-6. PMID 19339696 DOI: 10.1182/Blood-2008-11-190801  0.44
2009 Licht JD. Acute promyelocytic leukemia--weapons of mass differentiation. The New England Journal of Medicine. 360: 928-30. PMID 19246367 DOI: 10.1056/NEJMcibr0810371  0.01
2008 Thum T, Gross C, Fiedler J, Fischer T, Kissler S, Bussen M, Galuppo P, Just S, Rottbauer W, Frantz S, Castoldi M, Soutschek J, Koteliansky V, Rosenwald A, Basson MA, Licht JD, et al. MicroRNA-21 contributes to myocardial disease by stimulating MAP kinase signalling in fibroblasts. Nature. 456: 980-4. PMID 19043405 DOI: 10.1038/Nature07511  0.44
2008 Morrison DJ, Kim MK, Berkofsky-Fessler W, Licht JD. WT1 induction of mitogen-activated protein kinase phosphatase 3 represents a novel mechanism of growth suppression. Molecular Cancer Research : McR. 6: 1225-31. PMID 18644985 DOI: 10.1158/1541-7786.MCR-08-0078  0.04
2008 Polo JM, Ci W, Licht JD, Melnick A. Reversible disruption of BCL6 repression complexes by CD40 signaling in normal and malignant B cells Blood. 112: 644-651. PMID 18487509 DOI: 10.1182/Blood-2008-01-131813  0.44
2008 Buzzai M, Licht JD. New molecular concepts and targets in acute myeloid leukemia. Current Opinion in Hematology. 15: 82-7. PMID 18300752 DOI: 10.1097/MOH.0b013e3282f3ded0  0.04
2008 Kim MK, Mason JM, Li CM, Berkofsky-Fessler W, Jiang L, Choubey D, Grundy PE, Tycko B, Licht JD. A pathologic link between Wilms tumor suppressor gene, WT1, and IFI16. Neoplasia (New York, N.Y.). 10: 69-78. PMID 18231640 DOI: 10.1593/Neo.07869  0.01
2008 Marango J, Shimoyama M, Nishio H, Meyer JA, Min DJ, Sirulnik A, Martinez-Martinez Y, Chesi M, Bergsagel PL, Zhou MM, Waxman S, Leibovitch BA, Walsh MJ, Licht JD. The MMSET protein is a histone methyltransferase with characteristics of a transcriptional corepressor. Blood. 111: 3145-54. PMID 18156491 DOI: 10.1182/blood-2007-06-092122  0.01
2007 Frankfurt O, Licht JD, Tallman MS. Molecular characterization of acute myeloid leukemia and its impact on treatment. Current Opinion in Oncology. 19: 635-49. PMID 17906465 DOI: 10.1097/CCO.0b013e3282f10e55  0.01
2007 Hormaeche I, Licht JD. Chromatin modulation by oncogenic transcription factors: new complexity, new therapeutic targets. Cancer Cell. 11: 475-8. PMID 17560329 DOI: 10.1016/j.ccr.2007.05.005  0.01
2007 Rice KL, Licht JD. HOX deregulation in acute myeloid leukemia. The Journal of Clinical Investigation. 117: 865-8. PMID 17404613 DOI: 10.1172/JCI31861  0.01
2007 Denne M, Sauter M, Armbruester V, Licht JD, Roemer K, Mueller-Lantzsch N. Physical and functional interactions of human endogenous retrovirus proteins Np9 and Rec with the promyelocytic leukemia zinc finger protein Journal of Virology. 81: 5607-5616. PMID 17360752 DOI: 10.1128/JVI.02771-06  0.44
2007 McConnell MJ, Licht JD. The PLZF gene of t (11;17)-associated APL. Current Topics in Microbiology and Immunology. 313: 31-48. PMID 17217037 DOI: 10.1007/978-3-540-34594-7_3  0.44
2006 Basson MA, Watson-Johnson J, Shakya R, Akbulut S, Hyink D, Costantini FD, Wilson PD, Mason IJ, Licht JD. Branching morphogenesis of the ureteric epithelium during kidney development is coordinated by the opposing functions of GDNF and Sprouty1. Developmental Biology. 299: 466-77. PMID 17022962 DOI: 10.1016/J.Ydbio.2006.08.051  0.44
2006 Bowler T, Kosman D, Licht JD, Pick L. Computational identification of Ftz/Ftz-F1 downstream target genes. Developmental Biology. 299: 78-90. PMID 16996052 DOI: 10.1016/j.ydbio.2006.07.007  0.44
2006 Licht JD. Reconstructing a disease: What essential features of the retinoic acid receptor fusion oncoproteins generate acute promyelocytic leukemia? Cancer Cell. 9: 73-4. PMID 16473273 DOI: 10.1016/j.ccr.2006.01.024  0.01
2006 Mason JM, Morrison DJ, Basson MA, Licht JD. Sprouty proteins: multifaceted negative-feedback regulators of receptor tyrosine kinase signaling. Trends in Cell Biology. 16: 45-54. PMID 16337795 DOI: 10.1016/J.Tcb.2005.11.004  0.01
2005 Licht JD, Sternberg DW. The molecular pathology of acute myeloid leukemia. Hematology. American Society of Hematology. Education Program. 137-42. PMID 16304371 DOI: 10.1182/asheducation-2005.1.137  0.01
2005 Morrison DJ, English MA, Licht JD. WT1 induces apoptosis through transcriptional regulation of the proapoptotic Bcl-2 family member Bak Cancer Research. 65: 8174-8182. PMID 16166292 DOI: 10.1158/0008-5472.CAN-04-3657  0.44
2005 Takahashi S, Harigae H, Ishii KK, Inomata M, Fujiwara T, Yokoyama H, Ishizawa K, Kameoka J, Licht JD, Sasaki T, Kaku M. Over-expression of Flt3 induces NF-kappaB pathway and increases the expression of IL-6. Leukemia Research. 29: 893-9. PMID 15978940 DOI: 10.1016/j.leukres.2005.01.008  0.01
2005 Guidez F, Howell L, Isalan M, Cebrat M, Alani RM, Ivins S, Hormaeche I, McConnell MJ, Pierce S, Cole PA, Licht J, Zelent A. Histone acetyltransferase activity of p300 is required for transcriptional repression by the promyelocytic leukemia zinc finger protein. Molecular and Cellular Biology. 25: 5552-66. PMID 15964811 DOI: 10.1128/Mcb.25.13.5552-5566.2005  0.44
2005 Melnick AM, Adelson K, Licht JD. The theoretical basis of transcriptional therapy of cancer: can it be put into practice? Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology. 23: 3957-70. PMID 15867201 DOI: 10.1200/JCO.2005.14.498  0.01
2005 Lin W, Jing N, Basson MA, Dierich A, Licht J, Ang SL. Synergistic activity of Sef and Sprouty proteins in regulating the expression of Gbx2 in the mid-hindbrain region. Genesis (New York, N.Y. : 2000). 41: 110-5. PMID 15729686 DOI: 10.1002/Gene.20103  0.44
2005 Basson MA, Akbulut S, Watson-Johnson J, Simon R, Carroll TJ, Shakya R, Gross I, Martin GR, Lufkin T, McMahon AP, Wilson PD, Costantini FD, Mason IJ, Licht JD. Sprouty1 is a critical regulator of GDNF/RET-mediated kidney induction. Developmental Cell. 8: 229-39. PMID 15691764 DOI: 10.1016/J.Devcel.2004.12.004  0.44
2005 Gabrilove JL, McConnell M, Berkofsky-Fessler W, Sirulnik AL, Sharma S, Silverman LR, Isola L, Mandeli J, Licht J. A Phase I-II Pilot Study of Divalproex Sodium Alone and in Combination with All-Trans-Retinoic Acid (ATRA) in Relapsed or Refractory Acute Myeloid Leukemia. Blood. 106: 2799-2799. DOI: 10.1182/Blood.V106.11.2799.2799  0.01
2004 Olsson M, English MA, Mason J, Licht JD, Ekblom P. Despite WT1 binding sites in the promoter region of human and mouse nucleoporin glycoprotein 210, WT1 does not influence expression of GP210 Journal of Negative Results in Biomedicine. 3. PMID 15613247 DOI: 10.1186/1477-5751-3-7  0.44
2004 Li CM, Kim CE, Margolin AA, Guo M, Zhu J, Mason JM, Hensle TW, Murty VV, Grundy PE, Fearon ER, D'Agati V, Licht JD, Tycko B. CTNNB1 mutations and overexpression of Wnt/beta-catenin target genes in WT1-mutant Wilms' tumors. The American Journal of Pathology. 165: 1943-53. PMID 15579438 DOI: 10.1016/S0002-9440(10)63246-4  0.44
2004 Polo JM, Dell'Oso T, Ranuncolo SM, Cerchietti L, Beck D, Da Silva GF, Prive GG, Licht JD, Melnick A. Specific peptide interference reveals BCL6 transcriptional and oncogenic mechanisms in B-cell lymphoma cells. Nature Medicine. 10: 1329-35. PMID 15531890 DOI: 10.1038/Nm1134  0.01
2004 Tsavachidou D, Coleman ML, Athanasiadis G, Li S, Licht JD, Olson MF, Weber BL. SPRY2 is an inhibitor of the ras/extracellular signal-regulated kinase pathway in melanocytes and melanoma cells with wild-type BRAF but not with the V599E mutant. Cancer Research. 64: 5556-9. PMID 15313890 DOI: 10.1158/0008-5472.Can-04-1669  0.44
2004 Takahashi S, McConnell MJ, Harigae H, Kaku M, Sasaki T, Melnick AM, Licht JD. The Flt3 internal tandem duplication mutant inhibits the function of transcriptional repressors by blocking interactions with SMRT. Blood. 103: 4650-8. PMID 14982881 DOI: 10.1182/blood-2003-08-2759  0.44
2004 Chevallier N, Corcoran CM, Lennon C, Hyjek E, Chadburn A, Bardwell VJ, Licht JD, Melnick A. ETO protein of t(8;21) AML is a corepressor for Bcl-6 B-cell lymphoma oncoprotein. Blood. 103: 1454-63. PMID 14551142 DOI: 10.1182/Blood-2003-06-2081  0.44
2003 Ahmad KF, Melnick A, Lax S, Bouchard D, Liu J, Kiang CL, Mayer S, Takahashi S, Licht JD, Privé GG. Mechanism of SMRT corepressor recruitment by the BCL6 BTB domain. Molecular Cell. 12: 1551-64. PMID 14690607 DOI: 10.1016/S1097-2765(03)00454-4  0.01
2003 McConnell MJ, Chevallier N, Berkofsky-Fessler W, Giltnane JM, Malani RB, Staudt LM, Licht JD. Growth suppression by acute promyelocytic leukemia-associated protein PLZF is mediated by repression of c-myc expression. Molecular and Cellular Biology. 23: 9375-88. PMID 14645547 DOI: 10.1128/Mcb.23.24.9375-9388.2003  0.44
2003 Topisirovic I, Guzman ML, McConnell MJ, Licht JD, Culjkovic B, Neering SJ, Jordan CT, Borden KL. Aberrant eukaryotic translation initiation factor 4E-dependent mRNA transport impedes hematopoietic differentiation and contributes to leukemogenesis. Molecular and Cellular Biology. 23: 8992-9002. PMID 14645512 DOI: 10.1128/Mcb.23.24.8992-9002.2003  0.44
2003 Sirulnik A, Melnick A, Zelent A, Licht JD. Molecular pathogenesis of acute promyelocytic leukaemia and APL variants. Best Practice & Research. Clinical Haematology. 16: 387-408. PMID 12935958 DOI: 10.1016/S1521-6926(03)00062-8  0.01
2003 Gross I, Morrison DJ, Hyink DP, Georgas K, English MA, Mericskay M, Hosono S, Sassoon D, Wilson PD, Little M, Licht JD. The receptor tyrosine kinase regulator Sprouty1 is a target of the tumor suppressor WT1 and important for kidney development. The Journal of Biological Chemistry. 278: 41420-30. PMID 12882970 DOI: 10.1074/jbc.M306425200  0.44
2003 Tartaglia M, Niemeyer CM, Fragale A, Song X, Buechner J, Jung A, Hählen K, Hasle H, Licht JD, Gelb BD. Somatic mutations in PTPN11 in juvenile myelomonocytic leukemia, myelodysplastic syndromes and acute myeloid leukemia. Nature Genetics. 34: 148-50. PMID 12717436 DOI: 10.1038/Ng1156  0.44
2002 Melnick A, Licht JD. Histone deacetylases as therapeutic targets in hematologic malignancies. Current Opinion in Hematology. 9: 322-32. PMID 12042707 DOI: 10.1097/00062752-200207000-00010  0.01
2002 Dai MS, Chevallier N, Stone S, Heinrich MC, McConnell M, Reuter T, Broxmeyer HE, Licht JD, Lu L, Hoatlin ME. The effects of the Fanconi anemia zinc finger (FAZF) on cell cycle, apoptosis, and proliferation are differentiation stage-specific. The Journal of Biological Chemistry. 277: 26327-34. PMID 11986317 DOI: 10.1074/jbc.M201834200  0.44
2002 Melnick A, Carlile G, Ahmad KF, Kiang CL, Corcoran C, Bardwell V, Prive GG, Licht JD. Critical residues within the BTB domain of PLZF and Bcl-6 modulate interaction with corepressors. Molecular and Cellular Biology. 22: 1804-18. PMID 11865059 DOI: 10.1128/Mcb.22.6.1804-1818.2002  0.01
2001 Ward JO, McConnell MJ, Carlile GW, Pandolfi PP, Licht JD, Freedman LP. The acute promyelocytic leukemia-associated protein, promyelocytic leukemia zinc finger, regulates 1,25-dihydroxyvitamin D(3)-induced monocytic differentiation of U937 cells through a physical interaction with vitamin D(3) receptor. Blood. 98: 3290-300. PMID 11719366 DOI: 10.1182/Blood.V98.12.3290  0.44
2001 Srivastava DK, Tendler CL, Milani D, English MA, Licht JD, Wilson SH. The HIV-1 transactivator protein Tat is a potent inducer of the human DNA repair enzyme β-polymerase Aids. 15: 433-440. PMID 11242139 DOI: 10.1097/00002030-200103090-00001  0.44
2000 Melnick A, Carlile GW, McConnell MJ, Polinger A, Hiebert SW, Licht JD. AML-1/ETO fusion protein is a dominant negative inhibitor of transcriptional repression by the promyelocytic leukemia zinc finger protein. Blood. 96: 3939-47. PMID 11090081 DOI: 10.1182/Blood.V96.12.3939.H8003939_3939_3947  0.44
2000 Melnick A, Ahmad KF, Arai S, Polinger A, Ball H, Borden KL, Carlile GW, Prive GG, Licht JD. In-depth mutational analysis of the promyelocytic leukemia zinc finger BTB/POZ domain reveals motifs and residues required for biological and transcriptional functions. Molecular and Cellular Biology. 20: 6550-67. PMID 10938130 DOI: 10.1128/Mcb.20.17.6550-6567.2000  0.44
2000 Hosono S, Gross I, English MA, Hajra KM, Fearon ER, Licht JD. E-cadherin is a WT1 target gene. The Journal of Biological Chemistry. 275: 10943-53. PMID 10753894 DOI: 10.1074/Jbc.275.15.10943  0.44
2000 Melnick AM, Westendorf JJ, Polinger A, Carlile GW, Arai S, Ball HJ, Lutterbach B, Hiebert SW, Licht JD. The ETO protein disrupted in t(8;21)-associated acute myeloid leukemia is a corepressor for the promyelocytic leukemia zinc finger protein Molecular and Cellular Biology. 20: 2075-2086. PMID 10688654 DOI: 10.1128/Mcb.20.6.2075-2086.2000  0.44
1999 Zhang T, Xiong H, Kan LX, Zhang CK, Jiao XF, Fu G, Zhang QH, Lu L, Tong JH, Gu BW, Yu M, Liu JX, Licht J, Waxman S, Zelent A, et al. Genomic sequence, structural organization, molecular evolution, and aberrant rearrangement of promyelocytic leukemia zinc finger gene. Proceedings of the National Academy of Sciences of the United States of America. 96: 11422-7. PMID 10500192 DOI: 10.1073/Pnas.96.20.11422  0.44
1999 Ball HJ, Melnick A, Shaknovich R, Kohanski RA, Licht JD. The promyelocytic leukemia zinc finger (PLZF) protein binds DNA in a high molecular weight complex associated with cdc2 kinase Nucleic Acids Research. 27: 4106-4113. PMID 10497277 DOI: 10.1093/Nar/27.20.4106  0.44
1999 English MA, Licht JD. Tumor-associated WT1 missense mutants indicate that transcriptional activation by WT1 is critical for growth control Journal of Biological Chemistry. 274: 13258-13263. PMID 10224085 DOI: 10.1074/jbc.274.19.13258  0.44
1999 Koken MHM, Daniel MT, Gianni M, Zelent A, Licht J, Buzyn A, Minard P, Degos L, Varet B, De Thé H. Retinoic acid, but not arsenic trioxide, degrades the PLZF/RARα fusion protein, without inducing terminal differentiation or apoptosis, in a RA-therapy resistant t(11;17)q23;q21) APL patient Oncogene. 18: 1113-1118. PMID 10023688 DOI: 10.1038/Sj.Onc.1202414  0.44
1997 Koken MHM, Reid A, Quignon F, Chelbi-Alix MK, Davies JM, Kabarowski JHS, Zhu J, Dong S, Chen SJ, Chen Z, Tan CC, Licht J, Waxman S, De Thé H, Zelent A. Leukemia-associated retinoic acid receptor α fusion partners, PML and PLZF, heterodimerize and colocalize to nuclear bodies Proceedings of the National Academy of Sciences of the United States of America. 94: 10255-10260. PMID 9294197 DOI: 10.1073/Pnas.94.19.10255  0.44
1997 Li JY, English MA, Ball HJ, Yeyati PL, Waxman S, Licht JD. Sequence-specific DNA binding and transcriptional regulation by the promyelocytic leukemia zinc finger protein Journal of Biological Chemistry. 272: 22447-22455. PMID 9278395 DOI: 10.1074/jbc.272.36.22447  0.44
1997 Hanna-Rose W, Licht JD, Hansen U. Two evolutionarily conserved repression domains in the Drosophila Kruppel protein differ in activator specificity Molecular and Cellular Biology. 17: 4820-4829. PMID 9234738 DOI: 10.1128/Mcb.17.8.4820  0.44
1997 Holmes G, Boterashvili S, English M, Wainwright B, Licht J, Little M. Two N-terminal self-association domains are required for the dominant negative transcriptional activity of WT1 Denys-Drash mutant proteins. Biochemical and Biophysical Research Communications. 233: 723-728. PMID 9168922 DOI: 10.1006/Bbrc.1997.6545  0.01
1995 Reid A, Gould A, Brand N, Cook M, Strutt P, Li J, Licht J, Waxman S, Krumlauf R, Zelent A. Leukemia translocation gene, PLZF, is expressed with a speckled nuclear pattern in early hematopoietic progenitors Blood. 86: 4544-4552. PMID 8541544 DOI: 10.1182/Blood.V86.12.4544.Bloodjournal86124544  0.44
1995 Cook M, Gould A, Brand N, Davies J, Strutt P, Shaknovich R, Licht J, Waxman S, Chen Z, Gluecksohn-Waelsch S, Krumlauf R, Zelent A. Expression of the zinc-finger gene PLZF at rhombomere boundaries in the vertebrate hindbrain Proceedings of the National Academy of Sciences of the United States of America. 92: 2249-2253. PMID 7892256 DOI: 10.1073/Pnas.92.6.2249  0.44
1995 Reddy JC, Morris JC, Wang J, English MA, Haber DA, Shi Y, Licht JD. WT1-mediated transcriptional activation is inhibited by dominant negative mutant proteins Journal of Biological Chemistry. 270: 10878-10884. PMID 7738027 DOI: 10.1074/Jbc.270.18.10878  0.44
1994 Licht JD, Hanna-Rose W, Reddy JC, English MA, Ro M, Grossel M, Shaknovich R, Hansen U. Mapping and mutagenesis of the amino-terminal transcriptional repression domain of the Drosophila Krüppel protein Molecular and Cellular Biology. 14: 4057-4066. PMID 8196644 DOI: 10.1128/Mcb.14.6.4057  0.44
1994 Scott A, Kopecky K, Appelbaum F, Theil K, Grever, Chen I, Whittaker M, Griffith B, Licht J. HLA-DR-, CD33+, CD56+, CD16- myeloid/natural killer cell acute leukemia: a previously unrecognized form of acute leukemia potentially misdiagnosed as French-American-British acute myeloid leukemia-M3. Blood. 84: 244-255. DOI: 10.1182/Blood.V84.1.244.Bloodjournal841244  0.01
1993 Defranco C, Ro M, Grossel M, English MA, Hansen UM, Wagner JA, Licht JD. NGFIA (EGR1) Contains Transcription Activating Domains in Both the Amino Terminal and Carboxyl Terminal Regions of the Protein Biochemical and Biophysical Research Communications. 194: 425-431. PMID 8392841 DOI: 10.1006/Bbrc.1993.1837  0.44
1993 Licht JD, Ro M, English MA, Grossel M, Hansen U. Selective repression of transcriptional activators at a distance by the Drosophila Krüppel protein Proceedings of the National Academy of Sciences of the United States of America. 90: 11361-11365. PMID 8248254 DOI: 10.1073/Pnas.90.23.11361  0.44
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