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Robert F. Margolskee - Publications

Monell Chemical Senses Center, Philadelphia, PA, United States 

152 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2020 Hoffman MT, Kemp SB, Salas-Escabillas DJ, Zhang Y, Steele NG, The S, Long D, Benitz S, Yan W, Margolskee RF, Bednar F, Pasca di Magliano M, Wen HJ, Crawford HC. The Gustatory Sensory G-Protein GNAT3 Suppresses Pancreatic Cancer Progression in Mice. Cellular and Molecular Gastroenterology and Hepatology. PMID 32882403 DOI: 10.1016/j.jcmgh.2020.08.011  0.48
2020 Feng S, Achoute L, Margolskee RF, Jiang P, Wang H. Lipopolysaccharide-Induced Inflammatory Cytokine Expression in Taste Organoids. Chemical Senses. PMID 31993633 DOI: 10.1093/chemse/bjaa002  0.72
2019 Takai S, Watanabe Y, Sanematsu K, Yoshida R, Margolskee RF, Jiang P, Atsuta I, Koyano K, Ninomiya Y, Shigemura N. Effects of insulin signaling on mouse taste cell proliferation. Plos One. 14: e0225190. PMID 31714935 DOI: 10.1371/journal.pone.0225190  0.72
2019 Zheng X, Tizzano M, Redding K, He J, Peng X, Jiang P, Xu X, Zhou X, Margolskee RF. Gingival solitary chemosensory cells are immune sentinels for periodontitis. Nature Communications. 10: 4496. PMID 31582750 DOI: 10.1038/s41467-019-12505-x  0.72
2019 Wang Y, Zajac AL, Lei W, Christensen CM, Margolskee RF, Bouysset C, Golebiowski J, Zhao H, Fiorucci S, Jiang P. Metal Ions Activate the Human Taste Receptor TAS2R7. Chemical Senses. PMID 31066447 DOI: 10.1093/chemse/bjz024  0.72
2018 Du YW, Liu Q, Luo XC, Zhao DX, Xue JB, Feng P, Margolskee RF, Wang H, Huang L. Effects of Taste Signaling Protein Abolishment on Gut Inflammation in an Inflammatory Bowel Disease Mouse Model. Journal of Visualized Experiments : Jove. PMID 30474644 DOI: 10.3791/58668  0.72
2018 Lei W, Ren W, Ohmoto M, Urban JF, Matsumoto I, Margolskee RF, Jiang P. Activation of intestinal tuft cell-expressed Sucnr1 triggers type 2 immunity in the mouse small intestine. Proceedings of the National Academy of Sciences of the United States of America. PMID 29735652 DOI: 10.1073/pnas.1720758115  0.72
2018 Feng P, Chai J, Yi H, Redding K, Margolskee RF, Huang L, Wang H. Aggravated gut inflammation in mice lacking the taste signaling protein α-gustducin. Brain, Behavior, and Immunity. PMID 29678794 DOI: 10.1016/j.bbi.2018.04.010  0.72
2018 Qin Y, Sukumaran SK, Jyotaki M, Redding K, Jiang P, Margolskee RF. Gli3 is a negative regulator of Tas1r3-expressing taste cells. Plos Genetics. 14: e1007058. PMID 29415007 DOI: 10.1371/journal.pgen.1007058  0.72
2017 Lee RJ, Hariri BM, McMahon DB, Chen B, Doghramji L, Adappa ND, Palmer JN, Kennedy DW, Jiang P, Margolskee RF, Cohen NA. Bacterial d-amino acids suppress sinonasal innate immunity through sweet taste receptors in solitary chemosensory cells. Science Signaling. 10. PMID 28874606 DOI: 10.1126/scisignal.aam7703  0.72
2017 Ren W, Aihara E, Lei W, Gheewala N, Uchiyama H, Margolskee RF, Iwatsuki K, Jiang P. Transcriptome analyses of taste organoids reveal multiple pathways involved in taste cell generation. Scientific Reports. 7: 4004. PMID 28638111 DOI: 10.1038/s41598-017-04099-5  0.72
2016 Lewandowski BC, Sukumaran SK, Margolskee RF, Bachmanov AA. Amiloride-Insensitive Salt Taste Is Mediated by Two Populations of Type III Taste Cells with Distinct Transduction Mechanisms. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 36: 1942-53. PMID 26865617 DOI: 10.1523/JNEUROSCI.2947-15.2016  0.64
2015 Lei W, Ravoninjohary A, Li X, Margolskee RF, Reed DR, Beauchamp GK, Jiang P. Functional Analyses of Bitter Taste Receptors in Domestic Cats (Felis catus). Plos One. 10: e0139670. PMID 26488302 DOI: 10.1371/journal.pone.0139670  0.64
2015 Maillet EL, Cui M, Jiang P, Mezei M, Hecht E, Quijada J, Margolskee RF, Osman R, Max M. Characterization of the Binding Site of Aspartame in the Human Sweet Taste Receptor. Chemical Senses. 40: 577-86. PMID 26377607 DOI: 10.1093/chemse/bjv045  0.64
2015 Glendinning JI, Stano S, Holter M, Azenkot T, Goldman O, Margolskee RF, Vasselli JR, Sclafani A. Sugar-induced cephalic-phase insulin release is mediated by a T1r2+T1r3-independent taste transduction pathway in mice. American Journal of Physiology. Regulatory, Integrative and Comparative Physiology. ajpregu.00056.2015. PMID 26157055 DOI: 10.1152/ajpregu.00056.2015  0.64
2015 Takai S, Yasumatsu K, Inoue M, Iwata S, Yoshida R, Shigemura N, Yanagawa Y, Drucker DJ, Margolskee RF, Ninomiya Y. Glucagon-like peptide-1 is specifically involved in sweet taste transmission. Faseb Journal : Official Publication of the Federation of American Societies For Experimental Biology. 29: 2268-80. PMID 25678625 DOI: 10.1096/fj.14-265355  0.64
2014 Ren W, Lewandowski BC, Watson J, Aihara E, Iwatsuki K, Bachmanov AA, Margolskee RF, Jiang P. Single Lgr5- or Lgr6-expressing taste stem/progenitor cells generate taste bud cells ex vivo. Proceedings of the National Academy of Sciences of the United States of America. 111: 16401-6. PMID 25368147 DOI: 10.1073/pnas.1409064111  0.64
2014 Lei YT, Thuault SJ, Launay P, Margolskee RF, Kandel ER, Siegelbaum SA. Differential contribution of TRPM4 and TRPM5 nonselective cation channels to the slow afterdepolarization in mouse prefrontal cortex neurons. Frontiers in Cellular Neuroscience. 8: 267. PMID 25237295 DOI: 10.3389/fncel.2014.00267  0.64
2014 Parker MR, Feng D, Chamuris B, Margolskee RF. Expression and nuclear translocation of glucocorticoid receptors in type 2 taste receptor cells. Neuroscience Letters. 571: 72-7. PMID 24814581 DOI: 10.1016/j.neulet.2014.04.047  0.64
2014 Jiang P, Josue-Almqvist J, Jin X, Li X, Brand JG, Margolskee RF, Reed DR, Beauchamp GK. The bamboo-eating giant panda (Ailuropoda melanoleuca) has a sweet tooth: behavioral and molecular responses to compounds that taste sweet to humans. Plos One. 9: e93043. PMID 24671207 DOI: 10.1371/journal.pone.0093043  0.64
2014 Mokadem M, Zechner JF, Margolskee RF, Drucker DJ, Aguirre V. Effects of Roux-en-Y gastric bypass on energy and glucose homeostasis are preserved in two mouse models of functional glucagon-like peptide-1 deficiency. Molecular Metabolism. 3: 191-201. PMID 24634822 DOI: 10.1016/j.molmet.2013.11.010  0.64
2014 Lee RJ, Kofonow JM, Rosen PL, Siebert AP, Chen B, Doghramji L, Xiong G, Adappa ND, Palmer JN, Kennedy DW, Kreindler JL, Margolskee RF, Cohen NA. Bitter and sweet taste receptors regulate human upper respiratory innate immunity. The Journal of Clinical Investigation. 124: 1393-405. PMID 24531552 DOI: 10.1172/JCI72094  0.64
2014 Kokrashvili Z, Yee KK, Ilegems E, Iwatsuki K, Li Y, Mosinger B, Margolskee RF. Endocrine taste cells. The British Journal of Nutrition. 111: S23-9. PMID 24382120 DOI: 10.1017/S0007114513002262  0.64
2013 Lee RJ, Chen B, Redding KM, Margolskee RF, Cohen NA. Mouse nasal epithelial innate immune responses to Pseudomonas aeruginosa quorum-sensing molecules require taste signaling components. Innate Immunity. 20: 606-617. PMID 24045336 DOI: 10.1177/1753425913503386  0.64
2013 Mosinger B, Redding KM, Parker MR, Yevshayeva V, Yee KK, Dyomina K, Li Y, Margolskee RF. Genetic loss or pharmacological blockade of testes-expressed taste genes causes male sterility. Proceedings of the National Academy of Sciences of the United States of America. 110: 12319-24. PMID 23818598 DOI: 10.1073/pnas.1302827110  0.64
2013 Shigemura N, Iwata S, Yasumatsu K, Ohkuri T, Horio N, Sanematsu K, Yoshida R, Margolskee RF, Ninomiya Y. Angiotensin II modulates salty and sweet taste sensitivities. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 33: 6267-77. PMID 23575826 DOI: 10.1523/JNEUROSCI.5599-12.2013  0.64
2013 Zukerman S, Glendinning JI, Margolskee RF, Sclafani A. Impact of T1r3 and Trpm5 on carbohydrate preference and acceptance in C57BL/6 mice. Chemical Senses. 38: 421-37. PMID 23547138 DOI: 10.1093/chemse/bjt011  0.64
2013 Yee KK, Li Y, Redding KM, Iwatsuki K, Margolskee RF, Jiang P. Lgr5-EGFP marks taste bud stem/progenitor cells in posterior tongue. Stem Cells (Dayton, Ohio). 31: 992-1000. PMID 23377989 DOI: 10.1002/stem.1338  0.64
2013 Li Y, Kokrashvili Z, Mosinger B, Margolskee RF. Gustducin couples fatty acid receptors to GLP-1 release in colon. American Journal of Physiology. Endocrinology and Metabolism. 304: E651-60. PMID 23341498 DOI: 10.1152/ajpendo.00471.2012  0.64
2012 Glendinning JI, Gillman J, Zamer H, Margolskee RF, Sclafani A. The role of T1r3 and Trpm5 in carbohydrate-induced obesity in mice. Physiology & Behavior. 107: 50-8. PMID 22683548 DOI: 10.1016/j.physbeh.2012.05.023  0.64
2012 Nosrat IV, Margolskee RF, Nosrat CA. Targeted taste cell-specific overexpression of brain-derived neurotrophic factor in adult taste buds elevates phosphorylated TrkB protein levels in taste cells, increases taste bud size, and promotes gustatory innervation. The Journal of Biological Chemistry. 287: 16791-800. PMID 22442142 DOI: 10.1074/jbc.M111.328476  0.64
2012 Jiang P, Josue J, Li X, Glaser D, Li W, Brand JG, Margolskee RF, Reed DR, Beauchamp GK. Major taste loss in carnivorous mammals. Proceedings of the National Academy of Sciences of the United States of America. 109: 4956-61. PMID 22411809 DOI: 10.1073/pnas.1118360109  0.64
2012 Yasumatsu K, Ogiwara Y, Takai S, Yoshida R, Iwatsuki K, Torii K, Margolskee RF, Ninomiya Y. Umami taste in mice uses multiple receptors and transduction pathways. The Journal of Physiology. 590: 1155-70. PMID 22183726 DOI: 10.1113/jphysiol.2011.211920  0.64
2012 Eddy MC, Eschle BK, Peterson D, Lauras N, Margolskee RF, Delay ER. A conditioned aversion study of sucrose and SC45647 taste in TRPM5 knockout mice. Chemical Senses. 37: 391-401. PMID 21987728 DOI: 10.1093/chemse/bjr093  0.64
2012 Jiang P, Josue J, Li X, Glaser D, Li W, Brand JG, Margolskee RF, Reed DR, Beauchamp GK. Reply to Zhao and Zhang: Loss of taste receptor function in mammals is directly related to feeding specializations Proceedings of the National Academy of Sciences of the United States of America. 109: E1465. DOI: 10.1073/pnas.1205581109  0.64
2011 Yee KK, Sukumaran SK, Kotha R, Gilbertson TA, Margolskee RF. Glucose transporters and ATP-gated K+ (KATP) metabolic sensors are present in type 1 taste receptor 3 (T1r3)-expressing taste cells. Proceedings of the National Academy of Sciences of the United States of America. 108: 5431-6. PMID 21383163 DOI: 10.1073/pnas.1100495108  0.64
2010 Ilegems E, Iwatsuki K, Kokrashvili Z, Benard O, Ninomiya Y, Margolskee RF. REEP2 enhances sweet receptor function by recruitment to lipid rafts. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 30: 13774-83. PMID 20943918 DOI: 10.1523/JNEUROSCI.0091-10.2010  0.64
2010 Sclafani A, Glass DS, Margolskee RF, Glendinning JI. Gut T1R3 sweet taste receptors do not mediate sucrose-conditioned flavor preferences in mice. American Journal of Physiology. Regulatory, Integrative and Comparative Physiology. 299: R1643-50. PMID 20926763 DOI: 10.1152/ajpregu.00495.2010  0.64
2010 Reed DR, Margolskee RF. Gustation genetics: sweet gustducin! Chemical Senses. 35: 549-50. PMID 20660058 DOI: 10.1093/chemse/bjq059  0.64
2010 Murata Y, Yasuo T, Yoshida R, Obata K, Yanagawa Y, Margolskee RF, Ninomiya Y. Action potential-enhanced ATP release from taste cells through hemichannels. Journal of Neurophysiology. 104: 896-901. PMID 20519578 DOI: 10.1152/jn.00414.2010  0.64
2010 Colsoul B, Schraenen A, Lemaire K, Quintens R, Van Lommel L, Segal A, Owsianik G, Talavera K, Voets T, Margolskee RF, Kokrashvili Z, Gilon P, Nilius B, Schuit FC, Vennekens R. Loss of high-frequency glucose-induced Ca2+ oscillations in pancreatic islets correlates with impaired glucose tolerance in Trpm5-/- mice. Proceedings of the National Academy of Sciences of the United States of America. 107: 5208-13. PMID 20194741 DOI: 10.1073/pnas.0913107107  0.64
2010 Yoshida R, Ohkuri T, Jyotaki M, Yasuo T, Horio N, Yasumatsu K, Sanematsu K, Shigemura N, Yamamoto T, Margolskee RF, Ninomiya Y. Endocannabinoids selectively enhance sweet taste. Proceedings of the National Academy of Sciences of the United States of America. 107: 935-9. PMID 20080779 DOI: 10.1073/pnas.0912048107  0.64
2010 Kinnamon SC, Margolskee RF. Taste Transduction The Senses: a Comprehensive Reference. 4: 219-236. DOI: 10.1016/B978-012370880-9.00412-6  0.64
2010 Mosinger B, Damak S, Margolskee RF. G proteins in gustatory transduction Handbook of Cell Signaling, 2/E. 2: 1721-1726. DOI: 10.1016/B978-0-12-374145-5.00209-6  0.64
2009 Maillet EL, Margolskee RF, Mosinger B. Phenoxy herbicides and fibrates potently inhibit the human chemosensory receptor subunit T1R3. Journal of Medicinal Chemistry. 52: 6931-5. PMID 19817384 DOI: 10.1021/jm900823s  0.64
2009 Zukerman S, Touzani K, Margolskee RF, Sclafani A. Role of olfaction in the conditioned sucrose preference of sweet-ageusic T1R3 knockout mice. Chemical Senses. 34: 685-94. PMID 19736224 DOI: 10.1093/chemse/bjp055  0.64
2009 Kokrashvili Z, Mosinger B, Margolskee RF. T1r3 and alpha-gustducin in gut regulate secretion of glucagon-like peptide-1. Annals of the New York Academy of Sciences. 1170: 91-4. PMID 19686115 DOI: 10.1111/j.1749-6632.2009.04485.x  0.64
2009 Yoshida R, Miyauchi A, Yasuo T, Jyotaki M, Murata Y, Yasumatsu K, Shigemura N, Yanagawa Y, Obata K, Ueno H, Margolskee RF, Ninomiya Y. Discrimination of taste qualities among mouse fungiform taste bud cells. The Journal of Physiology. 587: 4425-39. PMID 19622604 DOI: 10.1113/jphysiol.2009.175075  0.64
2009 Kokrashvili Z, Mosinger B, Margolskee RF. Taste signaling elements expressed in gut enteroendocrine cells regulate nutrient-responsive secretion of gut hormones. The American Journal of Clinical Nutrition. 90: 822S-825S. PMID 19571229 DOI: 10.3945/ajcn.2009.27462T  0.64
2009 Lemon CH, Margolskee RF. Contribution of the T1r3 taste receptor to the response properties of central gustatory neurons. Journal of Neurophysiology. 101: 2459-71. PMID 19279151 DOI: 10.1152/jn.90892.2008  0.64
2009 Kokrashvili Z, Rodriguez D, Yevshayeva V, Zhou H, Margolskee RF, Mosinger B. Release of endogenous opioids from duodenal enteroendocrine cells requires Trpm5. Gastroenterology. 137: 598-606, 606.e1-2. PMID 19272386 DOI: 10.1053/j.gastro.2009.02.070  0.64
2009 Ohkuri T, Yasumatsu K, Horio N, Jyotaki M, Margolskee RF, Ninomiya Y. Multiple sweet receptors and transduction pathways revealed in knockout mice by temperature dependence and gurmarin sensitivity. American Journal of Physiology. Regulatory, Integrative and Comparative Physiology. 296: R960-71. PMID 19211717 DOI: 10.1152/ajpregu.91018.2008  0.64
2009 Zukerman S, Glendinning JI, Margolskee RF, Sclafani A. T1R3 taste receptor is critical for sucrose but not Polycose taste. American Journal of Physiology. Regulatory, Integrative and Comparative Physiology. 296: R866-76. PMID 19091911 DOI: 10.1152/ajpregu.90870.2008  0.64
2009 Wang H, Iguchi N, Rong Q, Zhou M, Ogunkorode M, Inoue M, Pribitkin EA, Bachmanov AA, Margolskee RF, Pfeifer K, Huang L. Expression of the voltage-gated potassium channel KCNQ1 in mammalian taste bud cells and the effect of its null-mutation on taste preferences. The Journal of Comparative Neurology. 512: 384-98. PMID 19006182 DOI: 10.1002/cne.21899  0.64
2008 Clapp TR, Trubey KR, Vandenbeuch A, Stone LM, Margolskee RF, Chaudhari N, Kinnamon SC. Tonic activity of Galpha-gustducin regulates taste cell responsivity. Febs Letters. 582: 3783-7. PMID 18930056 DOI: 10.1016/j.febslet.2008.10.007  0.64
2008 Damak S, Mosinger B, Margolskee RF. Transsynaptic transport of wheat germ agglutinin expressed in a subset of type II taste cells of transgenic mice. Bmc Neuroscience. 9: 96. PMID 18831764 DOI: 10.1186/1471-2202-9-96  0.64
2008 Tordoff MG, Shao H, Alarcón LK, Margolskee RF, Mosinger B, Bachmanov AA, Reed DR, McCaughey S. Involvement of T1R3 in calcium-magnesium taste. Physiological Genomics. 34: 338-48. PMID 18593862 DOI: 10.1152/physiolgenomics.90200.2008  0.64
2008 Egan JM, Margolskee RF. Taste cells of the gut and gastrointestinal chemosensation. Molecular Interventions. 8: 78-81. PMID 18403652 DOI: 10.1124/mi.8.2.5  0.64
2008 Lin W, Ogura T, Margolskee RF, Finger TE, Restrepo D. TRPM5-expressing solitary chemosensory cells respond to odorous irritants. Journal of Neurophysiology. 99: 1451-60. PMID 18160424 DOI: 10.1152/jn.01195.2007  0.64
2008 Talavera K, Yasumatsu K, Yoshida R, Margolskee RF, Voets T, Ninomiya Y, Nilius B. The taste transduction channel TRPM5 is a locus for bitter-sweet taste interactions. Faseb Journal : Official Publication of the Federation of American Societies For Experimental Biology. 22: 1343-55. PMID 18070821 DOI: 10.1096/fj.07-9591com  0.64
2008 Blednov YA, Walker D, Martinez M, Levine M, Damak S, Margolskee RF. Perception of sweet taste is important for voluntary alcohol consumption in mice. Genes, Brain, and Behavior. 7: 1-13. PMID 17376151 DOI: 10.1111/j.1601-183X.2007.00309.x  0.64
2008 Cui M, Jiang P, Maillet E, Max M, Margolskee RF, Osman R. Molecular models of sweet taste receptors provide insights into function Acs Symposium Series. 979: 117-132. DOI: 10.1021/bk-2008-0979.ch008  0.64
2008 Jiang P, Maillet E, Cui M, Osman R, Max M, Margolskee RF. Making sense of the sweet taste receptor Acs Symposium Series. 979: 48-64. DOI: 10.1021/bk-2008-0979.ch003  0.64
2007 Dyer J, Daly K, Salmon KS, Arora DK, Kokrashvili Z, Margolskee RF, Shirazi-Beechey SP. Intestinal glucose sensing and regulation of intestinal glucose absorption. Biochemical Society Transactions. 35: 1191-4. PMID 17956309 DOI: 10.1042/BST0351191  0.64
2007 Margolskee RF, Dyer J, Kokrashvili Z, Salmon KS, Ilegems E, Daly K, Maillet EL, Ninomiya Y, Mosinger B, Shirazi-Beechey SP. T1R3 and gustducin in gut sense sugars to regulate expression of Na+-glucose cotransporter 1. Proceedings of the National Academy of Sciences of the United States of America. 104: 15075-80. PMID 17724332 DOI: 10.1073/pnas.0706678104  0.64
2007 Jang HJ, Kokrashvili Z, Theodorakis MJ, Carlson OD, Kim BJ, Zhou J, Kim HH, Xu X, Chan SL, Juhaszova M, Bernier M, Mosinger B, Margolskee RF, Egan JM. Gut-expressed gustducin and taste receptors regulate secretion of glucagon-like peptide-1. Proceedings of the National Academy of Sciences of the United States of America. 104: 15069-74. PMID 17724330 DOI: 10.1073/pnas.0706890104  0.64
2007 Ogura T, Margolskee RF, Tallini YN, Shui B, Kotlikoff MI, Lin W. Immuno-localization of vesicular acetylcholine transporter in mouse taste cells and adjacent nerve fibers: indication of acetylcholine release. Cell and Tissue Research. 330: 17-28. PMID 17704949 DOI: 10.1007/s00441-007-0470-y  0.64
2007 Sclafani A, Zukerman S, Glendinning JI, Margolskee RF. Fat and carbohydrate preferences in mice: the contribution of alpha-gustducin and Trpm5 taste-signaling proteins. American Journal of Physiology. Regulatory, Integrative and Comparative Physiology. 293: R1504-13. PMID 17652359 DOI: 10.1152/ajpregu.00364.2007  0.64
2007 Zhang Z, Zhao Z, Margolskee R, Liman E. The transduction channel TRPM5 is gated by intracellular calcium in taste cells Journal of Neuroscience. 27: 5777-5786. PMID 17522321 DOI: 10.1523/JNEUROSCI.4973-06.2007  0.64
2007 Iwatsuki K, Liu HX, Grónder A, Singer MA, Lane TF, Grosschedl R, Mistretta CM, Margolskee RF. Wnt signaling interacts with Shh to regulate taste papilla development. Proceedings of the National Academy of Sciences of the United States of America. 104: 2253-8. PMID 17284610 DOI: 10.1073/pnas.0607399104  0.64
2007 Lin W, Margolskee R, Donnert G, Hell SW, Restrepo D. Olfactory neurons expressing transient receptor potential channel M5 (TRPM5) are involved in sensing semiochemicals. Proceedings of the National Academy of Sciences of the United States of America. 104: 2471-6. PMID 17267604 DOI: 10.1073/pnas.0610201104  0.64
2007 Romanov RA, Rogachevskaja OA, Bystrova MF, Jiang P, Margolskee RF, Kolesnikov SS. Afferent neurotransmission mediated by hemichannels in mammalian taste cells. The Embo Journal. 26: 657-67. PMID 17235286 DOI: 10.1038/sj.emboj.7601526  0.64
2006 Cui M, Jiang P, Maillet E, Max M, Margolskee RF, Osman R. The heterodimeric sweet taste receptor has multiple potential ligand binding sites. Current Pharmaceutical Design. 12: 4591-600. PMID 17168764 DOI: 10.2174/138161206779010350  0.52
2006 Danilova V, Damak S, Margolskee RF, Hellekant G. Taste responses to sweet stimuli in alpha-gustducin knockout and wild-type mice. Chemical Senses. 31: 573-80. PMID 16740645 DOI: 10.1093/chemse/bjj062  0.64
2006 Clapp TR, Medler KF, Damak S, Margolskee RF, Kinnamon SC. Mouse taste cells with G protein-coupled taste receptors lack voltage-gated calcium channels and SNAP-25. Bmc Biology. 4: 7. PMID 16573824 DOI: 10.1186/1741-7007-4-7  0.64
2006 Maruyama Y, Pereira E, Margolskee RF, Chaudhari N, Roper SD. Umami responses in mouse taste cells indicate more than one receptor. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 26: 2227-34. PMID 16495449 DOI: 10.1523/JNEUROSCI.4329-05.2006  0.64
2006 Delay ER, Hernandez NP, Bromley K, Margolskee RF. Sucrose and monosodium glutamate taste thresholds and discrimination ability of T1R3 knockout mice. Chemical Senses. 31: 351-7. PMID 16495435 DOI: 10.1093/chemse/bjj039  0.64
2006 Li Z, Benard O, Margolskee RF. Ggamma13 interacts with PDZ domain-containing proteins. The Journal of Biological Chemistry. 281: 11066-73. PMID 16473877 DOI: 10.1074/jbc.M600113200  0.64
2006 Damak S, Rong M, Yasumatsu K, Kokrashvili Z, Pérez CA, Shigemura N, Yoshida R, Mosinger B, Glendinning JI, Ninomiya Y, Margolskee RF. Trpm5 null mice respond to bitter, sweet, and umami compounds. Chemical Senses. 31: 253-64. PMID 16436689 DOI: 10.1093/chemse/bjj027  0.64
2005 Talavera K, Yasumatsu K, Voets T, Droogmans G, Shigemura N, Ninomiya Y, Margolskee RF, Nilius B. Heat activation of TRPM5 underlies thermal sensitivity of sweet taste. Nature. 438: 1022-5. PMID 16355226 DOI: 10.1038/nature04248  0.64
2005 Jiang P, Cui M, Zhao B, Snyder LA, Benard LM, Osman R, Max M, Margolskee RF. Identification of the cyclamate interaction site within the transmembrane domain of the human sweet taste receptor subunit T1R3. The Journal of Biological Chemistry. 280: 34296-305. PMID 16076846 DOI: 10.1074/jbc.M505255200  0.64
2005 Margolskee RF. Teaching resources. Sensory systems: taste perception. Science's Stke : Signal Transduction Knowledge Environment. 2005: tr20. PMID 15985643 DOI: 10.1126/stke.2902005tr20  0.64
2005 Glendinning JI, Bloom LD, Onishi M, Zheng KH, Damak S, Margolskee RF, Spector AC. Contribution of alpha-gustducin to taste-guided licking responses of mice. Chemical Senses. 30: 299-316. PMID 15800219 DOI: 10.1093/chemse/bji025  0.64
2005 Rong M, He W, Yasumatsu K, Kokrashvili Z, Perez CA, Mosinger B, Ninomiya Y, Margolskee RF, Damak S. Signal transduction of umami taste: insights from knockout mice. Chemical Senses. 30: i33-4. PMID 15738181 DOI: 10.1093/chemse/bjh099  0.64
2005 Jiang P, Cui M, Ji Q, Snyder L, Liu Z, Benard L, Margolskee RF, Osman R, Max M. Molecular mechanisms of sweet receptor function. Chemical Senses. 30: i17-8. PMID 15738096 DOI: 10.1093/chemse/bjh091  0.64
2005 Jiang P, Cui M, Zhao B, Liu Z, Snyder LA, Benard LM, Osman R, Margolskee RF, Max M. Lactisole interacts with the transmembrane domains of human T1R3 to inhibit sweet taste. The Journal of Biological Chemistry. 280: 15238-46. PMID 15668251 DOI: 10.1074/jbc.M414287200  0.64
2004 He W, Yasumatsu K, Varadarajan V, Yamada A, Lem J, Ninomiya Y, Margolskee RF, Damak S. Umami taste responses are mediated by alpha-transducin and alpha-gustducin. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 24: 7674-80. PMID 15342734 DOI: 10.1523/JNEUROSCI.2441-04.2004  0.64
2004 Jiang P, Ji Q, Liu Z, Snyder LA, Benard LM, Margolskee RF, Max M. The cysteine-rich region of T1R3 determines responses to intensely sweet proteins. The Journal of Biological Chemistry. 279: 45068-75. PMID 15299024 DOI: 10.1074/jbc.M406779200  0.64
2003 Caicedo A, Pereira E, Margolskee RF, Roper SD. Role of the G-protein subunit alpha-gustducin in taste cell responses to bitter stimuli. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 23: 9947-52. PMID 14586025  0.64
2003 Ruiz CJ, Wray K, Delay E, Margolskee RF, Kinnamon SC. Behavioral evidence for a role of alpha-gustducin in glutamate taste. Chemical Senses. 28: 573-9. PMID 14578119 DOI: 10.1093/chemse/bjg049  0.64
2003 Damak S, Rong M, Yasumatsu K, Kokrashvili Z, Varadarajan V, Zou S, Jiang P, Ninomiya Y, Margolskee RF. Detection of sweet and umami taste in the absence of taste receptor T1r3. Science (New York, N.Y.). 301: 850-3. PMID 12869700 DOI: 10.1126/science.1087155  0.64
2003 Pérez CA, Margolskee RF, Kinnamon SC, Ogura T. Making sense with TRP channels: store-operated calcium entry and the ion channel Trpm5 in taste receptor cells. Cell Calcium. 33: 541-9. PMID 12765699 DOI: 10.1016/S0143-4160(03)00059-9  0.64
2003 Medler KF, Margolskee RF, Kinnamon SC. Electrophysiological characterization of voltage-gated currents in defined taste cell types of mice. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 23: 2608-17. PMID 12684446  0.64
2003 Huang L, Max M, Margolskee RF, Su H, Masland RH, Euler T. G protein subunit G gamma 13 is coexpressed with G alpha o, G beta 3, and G beta 4 in retinal ON bipolar cells. The Journal of Comparative Neurology. 455: 1-10. PMID 12454992 DOI: 10.1002/cne.10396  0.64
2003 Damak S, Margolskee RF. G Proteins Mediating Taste Transduction Handbook of Cell Signaling. 2: 657-661. DOI: 10.1016/B978-012124546-7/50590-8  0.64
2002 He W, Danilova V, Zou S, Hellekant G, Max M, Margolskee RF, Damak S. Partial rescue of taste responses of alpha-gustducin null mice by transgenic expression of alpha-transducin. Chemical Senses. 27: 719-27. PMID 12379596 DOI: 10.1093/chemse/27.8.719  0.64
2002 Pérez CA, Huang L, Rong M, Kozak JA, Preuss AK, Zhang H, Max M, Margolskee RF. A transient receptor potential channel expressed in taste receptor cells. Nature Neuroscience. 5: 1169-76. PMID 12368808 DOI: 10.1038/nn952  0.64
2002 Ogura T, Margolskee RF, Kinnamon SC. Taste receptor cell responses to the bitter stimulus denatonium involve Ca2+ influx via store-operated channels. Journal of Neurophysiology. 87: 3152-5. PMID 12037215  0.64
2002 Margolskee RF. Molecular mechanisms of bitter and sweet taste transduction. The Journal of Biological Chemistry. 277: 1-4. PMID 11696554 DOI: 10.1074/jbc.R100054200  0.64
2002 Moriyama K, Bakre MM, Ahmed F, Spickofsky N, Max M, Margolskee RF. Assaying G protein-phosphodiesterase interactions in sensory systems. Methods in Enzymology. 345: 37-48. PMID 11665620 DOI: 10.1016/S0076-6879(02)45005-7  0.64
2002 Margolskee RF. Molecular mechanisms of taste transduction Pure and Applied Chemistry. 74: 1125-1133.  0.64
2001 Ruiz-Avila L, Wong GT, Damak S, Margolskee RF. Dominant loss of responsiveness to sweet and bitter compounds caused by a single mutation in alpha -gustducin. Proceedings of the National Academy of Sciences of the United States of America. 98: 8868-73. PMID 11447270 DOI: 10.1073/pnas.151235798  0.64
2001 Clapp TR, Stone LM, Margolskee RF, Kinnamon SC. Immunocytochemical evidence for co-expression of Type III IP3 receptor with signaling components of bitter taste transduction. Bmc Neuroscience. 2: 6. PMID 11346454 DOI: 10.1186/1471-2202-2-6  0.64
2001 Max M, Shanker YG, Huang L, Rong M, Liu Z, Campagne F, Weinstein H, Damak S, Margolskee RF. Tas1r3, encoding a new candidate taste receptor, is allelic to the sweet responsiveness locus Sac. Nature Genetics. 28: 58-63. PMID 11326277 DOI: 10.1038/88270  0.64
2001 Smith DV, Margolskee RF. Making sense of taste. Scientific American. 284: 32-9. PMID 11234504  0.64
2000 Calvert PD, Krasnoperova NV, Lyubarsky AL, Isayama T, Nicoló M, Kosaras B, Wong G, Gannon KS, Margolskee RF, Sidman RL, Pugh EN, Makino CL, Lem J. Phototransduction in transgenic mice after targeted deletion of the rod transducin alpha -subunit. Proceedings of the National Academy of Sciences of the United States of America. 97: 13913-8. PMID 11095744 DOI: 10.1073/pnas.250478897  0.64
2000 Gilbertson TA, Damak S, Margolskee RF. The molecular physiology of taste transduction. Current Opinion in Neurobiology. 10: 519-27. PMID 10981623 DOI: 10.1016/S0959-4388(00)00118-5  0.64
2000 Ruiz-Avila L, Ming D, Margolskee RF. An In vitro assay useful to determine the potency of several bitter compounds. Chemical Senses. 25: 361-8. PMID 10944498  0.64
2000 Yang R, Tabata S, Crowley HH, Margolskee RF, Kinnamon JC. Intrinsic choroidal neurons in the duck eye express galanin Journal of Comparative Neurology. 425: 24-33. PMID 10940939 DOI: 10.1002/1096-9861(20000911)425:1<24::AID-CNE3>3.0.CO;2-K  0.64
2000 McKinnon PJ, McLaughlin SK, Kapsetaki M, Margolskee RF. Extracellular matrix-associated protein Sc1 is not essential for mouse development. Molecular and Cellular Biology. 20: 656-60. PMID 10611244 DOI: 10.1128/MCB.20.2.656-660.2000  0.64
1999 Huang L, Shanker YG, Dubauskaite J, Zheng JZ, Yan W, Rosenzweig S, Spielman AI, Max M, Margolskee RF. Ggamma13 colocalizes with gustducin in taste receptor cells and mediates IP3 responses to bitter denatonium. Nature Neuroscience. 2: 1055-62. PMID 10570481 DOI: 10.1038/15981  0.64
1999 Ming D, Ninomiya Y, Margolskee RF. Blocking taste receptor activation of gustducin inhibits gustatory responses to bitter compounds. Proceedings of the National Academy of Sciences of the United States of America. 96: 9903-8. PMID 10449792 DOI: 10.1073/pnas.96.17.9903  0.64
1999 Wong GT, Ruiz-Avila L, Margolskee RF. Directing gene expression to gustducin-positive taste receptor cells. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 19: 5802-9. PMID 10407021  0.64
1998 Max M, Surya A, Takahashi JS, Margolskee RF, Knox BE. Light-dependent activation of rod transducin by pineal opsin. The Journal of Biological Chemistry. 273: 26820-6. PMID 9756926 DOI: 10.1074/jbc.273.41.26820  0.64
1998 Ming D, Ruiz-Avila L, Margolskee RF. Characterization and solubilization of bitter-responsive receptors that couple to gustducin. Proceedings of the National Academy of Sciences of the United States of America. 95: 8933-8. PMID 9671782 DOI: 10.1073/pnas.95.15.8933  0.64
1998 Kolesnikov SS, Margolskee RF. Extracellular K+ activates a K(+)- and H(+)-permeable conductance in frog taste receptor cells. The Journal of Physiology. 507: 415-32. PMID 9518702 DOI: 10.1111/j.1469-7793.1998.415bt.x  0.64
1997 Garret M, Bascles L, Boue-Grabot E, Sartor P, Charron G, Bloch B, Margolskee RF. An mRNA encoding a putative GABA-gated chloride channel is expressed in the human cardiac conduction system. Journal of Neurochemistry. 68: 1382-9. PMID 9084408  0.64
1997 Max M, Margolskee RF, Knox BE. Kinetics of P′-opsin's interactions with rod transducin Investigative Ophthalmology and Visual Science. 38: S594.  0.64
1996 Wong GT, Ruiz-Avila L, Ming D, Gannon KS, Margolskee RF. Biochemical and transgenic analysis of gustducin's role in bitter and sweet transduction. Cold Spring Harbor Symposia On Quantitative Biology. 61: 173-84. PMID 9246446  0.64
1996 McKinnon PJ, Kapsetaki M, Margolskee RF. The exon structure of the mouse Sc1 gene is very similar to the mouse Sparc gene. Genome Research. 6: 1077-83. PMID 8938431  0.64
1996 McKinnon PJ, Margolskee RF. SC1: a marker for astrocytes in the adult rodent brain is upregulated during reactive astrocytosis. Brain Research. 709: 27-36. PMID 8869553 DOI: 10.1016/0006-8993(95)01224-9  0.64
1996 Kinnamon SC, Margolskee RF. Mechanisms of taste transduction. Current Opinion in Neurobiology. 6: 506-13. PMID 8794107 DOI: 10.1016/S0959-4388(96)80057-2  0.64
1996 Wong GT, Gannon KS, Margolskee RF. Transduction of bitter and sweet taste by gustducin. Nature. 381: 796-800. PMID 8657284 DOI: 10.1038/381796a0  0.64
1996 Max M, Surya A, Takahashi JS, Margolskee RF, Knox BE. Light-dependent activation of transducin by pineal opsin Investigative Ophthalmology and Visual Science. 37: S811.  0.64
1995 Max M, McKinnon PJ, Seidenman KJ, Barrett RK, Applebury ML, Takahashi JS, Margolskee RF. Pineal opsin: a nonvisual opsin expressed in chick pineal. Science (New York, N.Y.). 267: 1502-6. PMID 7878470  0.64
1995 Ruiz-Avila L, McLaughlin SK, Wildman D, McKinnon PJ, Robichon A, Spickofsky N, Margolskee RF. Coupling of bitter receptor to phosphodiesterase through transducin in taste receptor cells. Nature. 376: 80-5. PMID 7596440 DOI: 10.1038/376080a0  0.64
1995 Kolesnikov SS, Margolskee RF. A cyclic-nucleotide-suppressible conductance activated by transducin in taste cells. Nature. 376: 85-8. PMID 7541117 DOI: 10.1038/376085a0  0.64
1994 Takami S, Getchell TV, McLaughlin SK, Margolskee RF, Getchell ML. Human taste cells express the G protein alpha-gustducin and neuron-specific enolase. Brain Research. Molecular Brain Research. 22: 193-203. PMID 8015379 DOI: 10.1016/0169-328X(94)90047-7  0.64
1994 McLaughlin SK, McKinnon PJ, Spickofsky N, Danho W, Margolskee RF. Molecular cloning of G proteins and phosphodiesterases from rat taste cells. Physiology & Behavior. 56: 1157-64. PMID 7878085 DOI: 10.1016/0031-9384(94)90360-3  0.64
1994 Spickofsky N, Robichon A, Danho W, Fry D, Greeley D, Graves B, Madison V, Margolskee RF. Biochemical analysis of the transducin-phosphodiesterase interaction. Nature Structural Biology. 1: 771-81. PMID 7634087  0.64
1994 McLaughlin S, Margolskee RF. The sense of taste: The internal molecular workings of the taste bud help it distinguish the bitter from the sweet Am.Sci.. 82: 538-545.  0.64
1993 McLaughlin SK, Margolskee RF. 33P is preferable to 35S for labeling probes used in in situ hybridization. Biotechniques. 15: 506-11. PMID 8217166  0.64
1993 McLaughlin SK, McKinnon PJ, Robichon A, Spickofsky N, Margolskee RF. Gustducin and transducin: a tale of two G proteins. Ciba Foundation Symposium. 179: 186-96; discussion 1. PMID 8168377  0.64
1993 Margolskee RF. The biochemistry and molecular biology of taste transduction. Current Opinion in Neurobiology. 3: 526-31. PMID 7693090 DOI: 10.1016/0959-4388(93)90051-Y  0.64
1993 Margolskee RF. The molecular biology of taste transduction. Bioessays : News and Reviews in Molecular, Cellular and Developmental Biology. 15: 645-50. PMID 7506022 DOI: 10.1002/bies.950151003  0.64
1993 Margolskee RF, McHendry-Rinde B, Horn R. Panning transfected cells for electrophysiological studies. Biotechniques. 15: 906-11. PMID 7505602  0.64
1992 Penna A, Fowler P, Bertoletti A, Guilhot S, Moss B, Margolskee RF, Cavalli A, Valli A, Fiaccadori F, Chisari FV. Hepatitis B virus (HBV)-specific cytotoxic T-cell (CTL) response in humans: characterization of HLA class II-restricted CTLs that recognize endogenously synthesized HBV envelope antigens. Journal of Virology. 66: 1193-8. PMID 1731098  0.64
1992 McLaughlin SK, McKinnon PJ, Margolskee RF. Gustducin is a taste-cell-specific G protein closely related to the transducins. Nature. 357: 563-9. PMID 1608467 DOI: 10.1038/357563a0  0.64
1992 Margolskee RF. Epstein-Barr virus based expression vectors. Current Topics in Microbiology and Immunology. 158: 67-95. PMID 1316260  0.64
1992 Pan LC, Margolskee RF, Blau HM. Cloning muscle isoforms of neural cell adhesion molecule using an episomal shuttle vector. Somatic Cell and Molecular Genetics. 18: 163-77. PMID 1315456 DOI: 10.1007/BF01233162  0.64
1992 Guilhot S, Fowler P, Portillo G, Margolskee RF, Ferrari C, Bertoletti A, Chisari FV. Hepatitis B virus (HBV)-specific cytotoxic T-cell response in humans: production of target cells by stable expression of HBV-encoded proteins in immortalized human B-cell lines. Journal of Virology. 66: 2670-8. PMID 1313893 DOI: 10.1128/jvi.66.5.2670-2678.1992  0.64
1992 Garret M, McHendry-Rinde B, Spickofsky N, Margolskee RF. Isolation of a clone which induces expression of the gene encoding the human tumor necrosis factor receptor. Gene. 111: 215-22. PMID 1311700 DOI: 10.1016/0378-1119(92)90689-M  0.64
1991 Spickofsky N, Margolskee RF. A highly efficient directional cDNA cloning method utilizing an asymmetrically tailed linker-primer plasmid. Nucleic Acids Research. 19: 7105-11. PMID 1766871  0.64
1990 Canfield V, Emanuel JR, Spickofsky N, Levenson R, Margolskee RF. Ouabain-resistant mutants of the rat Na,K-ATPase alpha 2 isoform identified by using an episomal expression vector. Molecular and Cellular Biology. 10: 1367-72. PMID 2157137  0.64
1988 Margolskee RF, Kavathas P, Berg P. Epstein-Barr virus shuttle vector for stable episomal replication of cDNA expression libraries in human cells. Molecular and Cellular Biology. 8: 2837-47. PMID 2841588  0.64
1986 Bowcock AM, Kavathas P, Margolskee RF, Herzenberg L, Cavalli-Sforza LL. An RFLP associated with pcDLeu2-14, a human T-cell differentiation antigen CD8 (Leu2) cDNA mapped to 2p12. Nucleic Acids Research. 14: 7817. PMID 2877435 DOI: 10.1093/nar/14.19.7817  0.64
1984 Margolskee RF, Nathans D. Simian virus 40 mutant T antigens with relaxed specificity for the nucleotide sequence at the viral DNA origin of replication. Journal of Virology. 49: 386-93. PMID 6319739  1
1983 Margolskee RF, Nathans D. Suppression of a VP1 mutant of simian virus 40 by missense mutations in serine codons of the viral agnogene. Journal of Virology. 48: 405-9. PMID 6312098  1
1979 Larsen SH, Margolskee RF, Nathans D. Alignment of the restriction map of mouse adenovirus FL with that of human adenovirus 2. Virology. 97: 406-14. PMID 573019 DOI: 10.1016/0042-6822(79)90351-9  1
1979 Shortle DR, Margolskee RF, Nathans D. Mutational analysis of the simian virus 40 replicon: pseudorevertants of mutants with a defective replication origin. Proceedings of the National Academy of Sciences of the United States of America. 76: 6128-31. PMID 230499  1
1979 Ausubel FM, Bird SC, Durbin KJ, Janssen KA, Margolskee RF, Peskin AP. Glutamine synthetase mutations which affect expression of nitrogen fixation genes in Klebsiella pneumoniae. Journal of Bacteriology. 140: 597-606. PMID 40960  1
1977 Ausubel F, Riedel G, Cannon F, Peskin A, Margolskee R. Cloning nitrogen fixing genes from Klebsiella pneumoniae in vitro and the isolation of NIF promoter mutants affecting glutamine synthetase regulation Basic Life Sciences. 9: 111-128. PMID 21649  1
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