Petrine Wellendorph - Publications

Affiliations: 
Biomedicine University of Basel, Basel, Basel-Stadt, Switzerland 

38 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2020 Kickinger S, Al-Khawaja A, Haugaard AS, Lie MEK, Bavo F, Löffler R, Damgaard M, Ecker GF, Frølund B, Wellendorph P. Exploring the molecular determinants for subtype-selectivity of 2-amino-1,4,5,6-tetrahydropyrimidine-5-carboxylic acid analogs as betaine/GABA transporter 1 (BGT1) substrate-inhibitors. Scientific Reports. 10: 12992. PMID 32747622 DOI: 10.1038/s41598-020-69908-w  0.4
2020 Falk-Petersen CB, Tsonkov TM, Nielsen MS, Harpsøe K, Bundgaard C, Frølund B, Kristiansen U, Gloriam DE, Wellendorph P. Discovery of a new class of orthosteric antagonists with nanomolar potency at extrasynaptic GABA receptors. Scientific Reports. 10: 10078. PMID 32572053 DOI: 10.1038/s41598-020-66821-0  0.4
2020 Dalby NO, Falk-Petersen CB, Leurs U, Scholze P, Krall J, Frølund B, Wellendorph P. Silencing of spontaneous activity at α4β1/3δ GABA receptors in hippocampal granule cells reveals different ligand pharmacology. British Journal of Pharmacology. PMID 32484592 DOI: 10.1111/bph.15146  0.4
2019 Giraudo A, Krall J, Bavo F, Nielsen B, Kongstad KT, Rolando B, De Blasio R, Gloriam DE, Löffler R, Thiesen L, Harpsøe K, Frydenvang K, Boschi D, Wellendorph P, Lolli ML, et al. Five-Membered N-Heterocyclic Scaffolds as Novel Amino Bioisosteres at γ-Aminobutyric Acid (GABA) Type A Receptors and GABA Transporters. Journal of Medicinal Chemistry. 62: 5797-5809. PMID 31117514 DOI: 10.1021/acs.jmedchem.9b00026  0.4
2019 Krall J, Bavo F, Falk-Petersen CB, Jensen CH, Nielsen JO, Tian Y, Anglani V, Kongstad KT, Piilgaard L, Nielsen B, Gloriam DE, Kehler J, Jensen A, Harpsøe K, Wellendorph P, et al. Discovery of 2-(Imidazo[1,2-b]pyridazin-2-yl)acetic Acid as a New Class of Ligands Selective for the γ-Hydroxybutyric Acid (GHB) High-Affinity Binding Sites. Journal of Medicinal Chemistry. PMID 30763084 DOI: 10.1021/acs.jmedchem.9b00131  0.4
2017 Krall J, Jensen CH, Bavo F, Falk-Petersen CB, Haugaard AS, Vogensen SB, Tian Y, Nittegaard-Nielsen M, Sigurdardóttir SB, Kehler J, Kongstad KT, Gloriam DE, Clausen RP, Harpsøe K, Wellendorph P, et al. Molecular hybridization of potent and selective γ-Hydroxybutyric Acid (GHB) ligands; Design, synthesis, binding studies, and molecular modelling of novel 3-hydroxycyclopent-1-enecarboxylic Acid (HOCPCA) and trans-γ-hydroxycrotonic acid (T-HCA) Analogs. Journal of Medicinal Chemistry. PMID 29028338 DOI: 10.1021/acs.jmedchem.7b01351  0.4
2017 Jørgensen L, Al-Khawaja A, Kickinger S, Vogensen SB, Skovgaard-Petersen J, Jensen ER, Borkar N, Löffler R, Madsen KK, Bräuner-Osborne H, Schousboe A, Ecker GF, Wellendorph P, Clausen RP. Structure-activity relationship, pharmacological characterization and molecular modeling of non-competitive inhibitors of the betaine/γ-aminobutyric acid transporter 1 (BGT1). Journal of Medicinal Chemistry. PMID 28991462 DOI: 10.1021/acs.jmedchem.7b00924  0.48
2017 Frandsen IO, Boesgaard MW, Fidom K, Hauser AS, Isberg V, Bräuner-Osborne H, Wellendorph P, Gloriam DE. Identification of Histamine H Receptor Ligands Using a New Crystal Structure Fragment-based Method. Scientific Reports. 7: 4829. PMID 28684785 DOI: 10.1038/s41598-017-05058-w  0.48
2017 Falk-Petersen CB, Søgaard R, Madsen KL, Klein AB, Frølund B, Wellendorph P. Development of a Robust Mammalian Cell-based Assay for Studying Recombinant α4 β1/3 δ GABAA Receptor Subtypes. Basic & Clinical Pharmacology & Toxicology. PMID 28299900 DOI: 10.1111/bcpt.12778  0.4
2017 Jensen CH, Hansen HD, Bay T, Vogensen SB, Lehel S, Thiesen L, Bundgaard C, Clausen RP, Knudsen GM, Herth MM, Wellendorph P, Frølund B. Radiosynthesis and Evaluation of [(11)C]3-Hydroxycyclopent-1-enecarboxylic Acid as Potential PET Ligand for the High-Affinity γ-Hydroxybutyric Acid Binding Sites. Acs Chemical Neuroscience. 8: 22-27. PMID 28095676 DOI: 10.1021/acschemneuro.6b00335  0.4
2016 Jørgensen S, Have CT, Underwood CR, Johansen LD, Wellendorph P, Gjesing AP, Jørgensen CV, Quan S, Rui G, Inoue A, Linneberg A, Grarup N, Jun W, Pedersen O, Hansen T, et al. Genetic Variations in the Human GPRC6A Receptor Control Cell Surface Expression and Function. The Journal of Biological Chemistry. PMID 27986810 DOI: 10.1074/jbc.M116.756577  0.48
2015 Damgaard M, Al-Khawaja A, Vogensen SB, Jurik A, Sijm M, Lie ME, Bæk MI, Rosenthal E, Jensen AA, Ecker GF, Frølund B, Wellendorph P, Clausen RP. Identification of the First Highly Subtype-Selective Inhibitor of Human GABA Transporter GAT3. Acs Chemical Neuroscience. PMID 26154082 DOI: 10.1021/acschemneuro.5b00150  0.48
2015 Thiesen L, Kehler J, Clausen RP, Frølund B, Bundgaard C, Wellendorph P. In Vitro and In Vivo Evidence for Active Brain Uptake of the GHB Analog HOCPCA by the Monocarboxylate Transporter Subtype 1. The Journal of Pharmacology and Experimental Therapeutics. 354: 166-74. PMID 25986445 DOI: 10.1124/jpet.115.224543  0.4
2014 Eghorn LF, Hoestgaard-Jensen K, Kongstad KT, Bay T, Higgins D, Frølund B, Wellendorph P. Positive allosteric modulation of the GHB high-affinity binding site by the GABAA receptor modulator monastrol and the flavonoid catechin. European Journal of Pharmacology. 740: 570-7. PMID 24973695 DOI: 10.1016/j.ejphar.2014.06.028  0.4
2014 Al-Khawaja A, Petersen JG, Damgaard M, Jensen MH, Vogensen SB, Lie ME, Kragholm B, Bräuner-Osborne H, Clausen RP, Frølund B, Wellendorph P. Pharmacological identification of a guanidine-containing β-alanine analogue with low micromolar potency and selectivity for the betaine/GABA transporter 1 (BGT1). Neurochemical Research. 39: 1988-96. PMID 24852577 DOI: 10.1007/s11064-014-1336-9  0.48
2014 Smajilovic S, Wellendorph P, Bräuner-Osborne H. Promiscuous seven transmembrane receptors sensing L-α-amino acids. Current Pharmaceutical Design. 20: 2693-702. PMID 23886393 DOI: 10.2174/13816128113199990576  0.48
2013 Vogensen SB, Marek A, Bay T, Wellendorph P, Kehler J, Bundgaard C, Frølund B, Pedersen MHF, Clausen RP. New synthesis and tritium labeling of a selective ligand for studying high-affinity γ-hydroxybutyrate (GHB) binding sites Journal of Medicinal Chemistry. 56: 8201-8205. PMID 24053696 DOI: 10.1021/jm4011719  0.4
2013 Jacobsen SE, Nørskov-Lauritsen L, Thomsen AR, Smajilovic S, Wellendorph P, Larsson NH, Lehmann A, Bhatia VK, Bräuner-Osborne H. Delineation of the GPRC6A receptor signaling pathways using a mammalian cell line stably expressing the receptor. The Journal of Pharmacology and Experimental Therapeutics. 347: 298-309. PMID 24008333 DOI: 10.1124/jpet.113.206276  0.48
2013 Jensen AA, Plath N, Pedersen MH, Isberg V, Krall J, Wellendorph P, Stensbøl TB, Gloriam DE, Krogsgaard-Larsen P, Frølund B. Design, synthesis, and pharmacological characterization of N- and O-substituted 5,6,7,8-tetrahydro-4H-isoxazolo[4,5-d]azepin-3-ol analogues: novel 5-HT(2A)/5-HT(2C) receptor agonists with pro-cognitive properties. Journal of Medicinal Chemistry. 56: 1211-27. PMID 23301527 DOI: 10.1021/jm301656h  0.48
2013 Smajilovic S, Clemmensen C, Johansen LD, Wellendorph P, Holst JJ, Thams PG, Ogo E, Bräuner-Osborne H. The L-α-amino acid receptor GPRC6A is expressed in the islets of Langerhans but is not involved in L-arginine-induced insulin release. Amino Acids. 44: 383-90. PMID 22714012 DOI: 10.1007/s00726-012-1341-8  0.48
2012 Absalom N, Eghorn LF, Villumsen IS, Karim N, Bay T, Olsen JV, Knudsen GM, Bräuner-Osborne H, Frølund B, Clausen RP, Chebib M, Wellendorph P. α4βδ GABA(A) receptors are high-affinity targets for γ-hydroxybutyric acid (GHB). Proceedings of the National Academy of Sciences of the United States of America. 109: 13404-9. PMID 22753476 DOI: 10.1073/pnas.1204376109  0.48
2012 Pan Y, Gerasimov MR, Kvist T, Wellendorph P, Madsen KK, Pera E, Lee H, Schousboe A, Chebib M, Bräuner-Osborne H, Craft CM, Brodie JD, Schiffer WK, Dewey SL, Miller SR, et al. (1S, 3S)-3-amino-4-difluoromethylenyl-1-cyclopentanoic acid (CPP-115), a potent γ-aminobutyric acid aminotransferase inactivator for the treatment of cocaine addiction Journal of Medicinal Chemistry. 55: 357-366. PMID 22128851 DOI: 10.1021/jm201231w  0.48
2011 Gloriam DE, Wellendorph P, Johansen LD, Thomsen AR, Phonekeo K, Pedersen DS, Bräuner-Osborne H. Chemogenomic discovery of allosteric antagonists at the GPRC6A receptor. Chemistry & Biology. 18: 1489-98. PMID 22118683 DOI: 10.1016/j.chembiol.2011.09.012  0.48
2010 Wellendorph P, Johansen LD, Bräuner-Osborne H. The emerging role of promiscuous 7TM receptors as chemosensors for food intake. Vitamins and Hormones. 84: 151-84. PMID 21094899 DOI: 10.1016/B978-0-12-381517-0.00005-9  0.48
2010 Sabbatini P, Wellendorph P, Høg S, Pedersen MHF, Bräuner-Osborne H, Martiny L, Frølund B, Clausen RP. Design, synthesis, and in vitro pharmacology of new radiolabeled γ-hydroxybutyric acid analogues including photolabile analogues with irreversible binding to the high-affinity γ-hydroxybutyric acid binding sites Journal of Medicinal Chemistry. 53: 6506-6510. PMID 20715819 DOI: 10.1021/jm1006325  0.48
2010 Wellendorph P, Høg S, Sabbatini P, Pedersen MHF, Martiny L, Knudsen GM, Frølund B, Clausen RP, Bräuner-Osborne H. Novel radioiodinated γ-hydroxybutyric acid analogues for radiolabeling and photolinking of high-affinity γ-hydroxybutyric acid binding sites Journal of Pharmacology and Experimental Therapeutics. 335: 458-464. PMID 20696866 DOI: 10.1124/jpet.110.170670  0.48
2009 Wellendorph P, Høg S, Skonberg C, Bräuner-Osborne H. Phenylacetic acids and the structurally related non-steroidal anti-inflammatory drug diclofenac bind to specific gamma-hydroxybutyric acid sites in rat brain. Fundamental & Clinical Pharmacology. 23: 207-13. PMID 19645815 DOI: 10.1111/j.1472-8206.2008.00664.x  0.48
2009 Wellendorph P, Johansen LD, Bräuner-Osborne H. Molecular pharmacology of promiscuous seven transmembrane receptors sensing organic nutrients. Molecular Pharmacology. 76: 453-65. PMID 19487246 DOI: 10.1124/mol.109.055244  0.48
2009 Wellendorph P, Johansen LD, Jensen AA, Casanova E, Gassmann M, Deprez P, Clément-Lacroix P, Bettler B, Bräuner-Osborne H. No evidence for a bone phenotype in GPRC6A knockout mice under normal physiological conditions. Journal of Molecular Endocrinology. 42: 215-23. PMID 19103720 DOI: 10.1677/JME-08-0149  0.32
2008 Høg S, Wellendorph P, Nielsen B, Frydenvang K, Dahl IF, Bräuner-Osborne H, Brehm L, Frølund B, Clausen RP. Novel high-affinity and selective biaromatic 4-substituted γ-hydroxybutyric acid (GHB) analogues as GHB ligands: Design, synthesis, and binding studies Journal of Medicinal Chemistry. 51: 8088-8095. PMID 19053823 DOI: 10.1021/jm801112u  0.48
2007 Wellendorph P, Burhenne N, Christiansen B, Walter B, Schmale H, Bräuner-Osborne H. The rat GPRC6A: cloning and characterization. Gene. 396: 257-67. PMID 17478059 DOI: 10.1016/j.gene.2007.03.008  0.48
2007 Bräuner-Osborne H, Wellendorph P, Jensen AA. Structure, pharmacology and therapeutic prospects of family C G-protein coupled receptors. Current Drug Targets. 8: 169-84. PMID 17266540 DOI: 10.2174/138945007779315614  0.48
2006 Christiansen B, Wellendorph P, Bräuner-Osborne H. Activity of L-alpha-amino acids at the promiscuous goldfish odorant receptor 5.24. European Journal of Pharmacology. 536: 98-101. PMID 16546162 DOI: 10.1016/j.ejphar.2006.02.015  0.48
2006 Christiansen B, Wellendorph P, Bräuner-Osborne H. Known regulators of nitric oxide synthase and arginase are agonists at the human G-protein-coupled receptor GPRC6A. British Journal of Pharmacology. 147: 855-63. PMID 16491104 DOI: 10.1038/sj.bjp.0706682  0.48
2005 Wellendorph P, Høg S, Greenwood JR, de Lichtenberg A, Nielsen B, Frølund B, Brehm L, Clausen RP, Bräuner-Osborne H. Novel cyclic gamma-hydroxybutyrate (GHB) analogs with high affinity and stereoselectivity of binding to GHB sites in rat brain. The Journal of Pharmacology and Experimental Therapeutics. 315: 346-51. PMID 16014570 DOI: 10.1124/jpet.105.090472  0.48
2005 Wellendorph P, Hansen KB, Balsgaard A, Greenwood JR, Egebjerg J, Bräuner-Osborne H. Deorphanization of GPRC6A: a promiscuous L-alpha-amino acid receptor with preference for basic amino acids. Molecular Pharmacology. 67: 589-97. PMID 15576628 DOI: 10.1124/mol.104.007559  0.48
2004 Wellendorph P, Bräuner-Osborne H. Molecular cloning, expression, and sequence analysis of GPRC6A, a novel family C G-protein-coupled receptor. Gene. 335: 37-46. PMID 15194188 DOI: 10.1016/j.gene.2004.03.003  0.48
2003 Kaupmann K, Cryan JF, Wellendorph P, Mombereau C, Sansig G, Klebs K, Schmutz M, Froestl W, van der Putten H, Mosbacher J, Bräuner-Osborne H, Waldmeier P, Bettler B. Specific gamma-hydroxybutyrate-binding sites but loss of pharmacological effects of gamma-hydroxybutyrate in GABA(B)(1)-deficient mice. The European Journal of Neuroscience. 18: 2722-30. PMID 14656321 DOI: 10.1111/j.1460-9568.2003.03013.x  0.48
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