| Year |
Citation |
Score |
| 2024 |
Breitwieser GE, Cippitelli A, Wang Y, Pelletier O, Dershem R, Wei J, Toll L, Fakhoury B, Brunori G, Metpally R, Carey DJ, Robishaw J. Rare GPR37L1 variants reveal potential association between GPR37L1 and disorders of anxiety and migraine. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. PMID 38569927 DOI: 10.1523/JNEUROSCI.1226-23.2024 |
0.315 |
|
| 2021 |
Toll L, Cippitelli A, Ozawa A. The NOP Receptor System in Neurological and Psychiatric Disorders: Discrepancies, Peculiarities and Clinical Progress in Developing Targeted Therapies. Cns Drugs. PMID 34057709 DOI: 10.1007/s40263-021-00821-0 |
0.377 |
|
| 2020 |
Groom S, Blum NK, Conibear AE, Disney A, Hill R, Husbands SM, Li Y, Toll L, Kliewer A, Schulz S, Henderson G, Kelly E, Bailey CP. A novel G protein-biased agonist at the μ opioid receptor induces substantial receptor desensitization through G protein-coupled receptor kinase. British Journal of Pharmacology. PMID 33245558 DOI: 10.1111/bph.15334 |
0.389 |
|
| 2020 |
Targowska-Duda KM, Ozawa A, Bertels Z, Cippitelli A, Marcus JL, Mielke-Maday HK, Zribi G, Rainey AN, Kieffer BL, Pradhan AA, Toll L. NOP receptor agonist attenuates nitroglycerin-induced migraine-like symptoms in mice. Neuropharmacology. 170: 108029. PMID 32278976 DOI: 10.1016/J.Neuropharm.2020.108029 |
0.325 |
|
| 2019 |
Toll L, Ozawa A, Cippitelli A. NOP-Related Mechanisms in Pain and Analgesia. Handbook of Experimental Pharmacology. PMID 31119465 DOI: 10.1007/164_2019_214 |
0.331 |
|
| 2019 |
Mann A, Moulédous L, Froment C, O'Neill PR, Dasgupta P, Günther T, Brunori G, Kieffer BL, Toll L, Bruchas MR, Zaveri NT, Schulz S. Agonist-selective NOP receptor phosphorylation correlates in vitro and in vivo and reveals differential post-activation signaling by chemically diverse agonists. Science Signaling. 12. PMID 30914485 DOI: 10.1126/Scisignal.Aau8072 |
0.435 |
|
| 2019 |
Toll L, Ozawa A, Cippitelli A. Involvement of NOP receptors, the fourth opioid receptor, on pain and drug abuse Ibro Reports. 6. DOI: 10.1016/J.Ibror.2019.07.027 |
0.417 |
|
| 2018 |
Kumar V, Polgar WE, Cami-Kobeci G, Thomas MP, Khroyan TV, Toll L, Husbands SM. Synthesis, Biological Evaluation, and SAR Studies of 14β-phenylacetyl Substituted 17-cyclopropylmethyl-7, 8-dihydronoroxymorphinones Derivatives: Ligands With Mixed NOP and Opioid Receptor Profile. Frontiers in Psychiatry. 9: 430. PMID 30283364 DOI: 10.3389/fpsyt.2018.00430 |
0.498 |
|
| 2018 |
Cippitelli A, Brunori G, Schoch J, Armishaw CJ, Wu J, Zaveri NT, Giulianotti MA, Welmaker GS, Toll L. Differential regulation of alcohol taking and seeking by antagonism at α4β2 and α3β4 nAChRs. Psychopharmacology. PMID 29572652 DOI: 10.1007/S00213-018-4883-Y |
0.318 |
|
| 2017 |
Wu J, Cippitelli A, Zhang Y, Debevec G, Schoch J, Ozawa A, Yu Y, Liu H, Chen W, Houghten RA, Welmaker GS, Giulianotti MA, Toll L. Highly Selective and Potent α4β2 nAChR Antagonist Inhibits Nicotine Self-Administration and Reinstatement in Rats. Journal of Medicinal Chemistry. PMID 29178785 DOI: 10.1021/Acs.Jmedchem.7B01250 |
0.341 |
|
| 2017 |
Madariaga-Mazón A, Marmolejo-Valencia AF, Li Y, Toll L, Houghten RA, Martinez-Mayorga K. Mu-Opioid receptor biased ligands: A safer and painless discovery of analgesics? Drug Discovery Today. 22: 1719-1729. PMID 28743488 DOI: 10.1016/J.Drudis.2017.07.002 |
0.488 |
|
| 2017 |
Spetea M, Eans SO, Ganno ML, Lantero A, Mairegger M, Toll L, Schmidhammer H, McLaughlin JP. Selective κ opioid receptor partial agonist HS666 produces potent antinociception without inducing aversion after i.c.v. administration in mice. British Journal of Pharmacology. PMID 28494108 DOI: 10.1111/Bph.13854 |
0.492 |
|
| 2017 |
Khroyan TV, Cippitelli A, Toll N, Lawson JA, Crossman W, Polgar WE, Toll L. and Profile of PPL-101 and PPL-103: Mixed Opioid Partial Agonist Analgesics with Low Abuse Potential. Frontiers in Psychiatry. 8: 52. PMID 28446883 DOI: 10.3389/Fpsyt.2017.00052 |
0.384 |
|
| 2017 |
Cippitelli A, Wu J, Debevec G, Armishaw C, Welmaker GS, Giulianotti M, Toll L. Involvement of α4β2 and α3β4 nicotinic receptor subtypes in alcohol taking and seeking Alcohol. 60: 209-210. DOI: 10.1016/J.Alcohol.2017.02.212 |
0.346 |
|
| 2016 |
Toll L, Bruchas MR, Calo' G, Cox BM, Zaveri NT. Nociceptin/Orphanin FQ Receptor Structure, Signaling, Ligands, Functions, and Interactions with Opioid Systems. Pharmacological Reviews. 68: 419-57. PMID 26956246 DOI: 10.1124/Pr.114.009209 |
0.489 |
|
| 2016 |
Ciesla L, Okine M, Rosenberg A, Dossou KSS, Toll L, Wainer IW, Moaddel R. Development and characterization of the α3β4α5 nicotinic receptor cellular membrane affinity chromatography column and its application for on line screening of plant extracts. Journal of Chromatography. A. 1431: 138-144. PMID 26774122 DOI: 10.1016/J.Chroma.2015.12.065 |
0.381 |
|
| 2015 |
Ozawa A, Brunori G, Mercatelli D, Wu J, Cippitelli A, Zou B, Xie XS, Williams M, Zaveri NT, Low S, Scherrer G, Kieffer BL, Toll L. Knock-In Mice with NOP-eGFP Receptors Identify Receptor Cellular and Regional Localization. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 35: 11682-93. PMID 26290245 DOI: 10.1523/Jneurosci.5122-14.2015 |
0.465 |
|
| 2015 |
Wnorowski A, Sadowska M, Paul RK, Singh NS, Boguszewska-Czubara A, Jimenez L, Abdelmohsen K, Toll L, Jozwiak K, Bernier M, Wainer IW. Activation of β2-adrenergic receptor by (R,R')-4'-methoxy-1-naphthylfenoterol inhibits proliferation and motility of melanoma cells. Cellular Signalling. 27: 997-1007. PMID 25703025 DOI: 10.1016/J.Cellsig.2015.02.012 |
0.671 |
|
| 2015 |
Cippitelli A, Wu J, Gaiolini KA, Mercatelli D, Schoch J, Gorman M, Ramirez A, Ciccocioppo R, Khroyan TV, Yasuda D, Zaveri NT, Pascual C, Xie XS, Toll L. AT-1001: a high-affinity α3β4 nAChR ligand with novel nicotine-suppressive pharmacology. British Journal of Pharmacology. 172: 1834-45. PMID 25440006 DOI: 10.1111/Bph.13034 |
0.343 |
|
| 2015 |
Khroyan TV, Wu J, Polgar WE, Cami-Kobeci G, Fotaki N, Husbands SM, Toll L. BU08073 a buprenorphine analogue with partial agonist activity at μ-receptors in vitro but long-lasting opioid antagonist activity in vivo in mice. British Journal of Pharmacology. 172: 668-80. PMID 24903063 DOI: 10.1111/Bph.12796 |
0.505 |
|
| 2015 |
Cox BM, Christie MJ, Devi L, Toll L, Traynor JR. Challenges for opioid receptor nomenclature: IUPHAR Review 9. British Journal of Pharmacology. 172: 317-23. PMID 24528283 DOI: 10.1111/Bph.12612 |
0.482 |
|
| 2014 |
Woo AY, Jozwiak K, Toll L, Tanga MJ, Kozocas JA, Jimenez L, Huang Y, Song Y, Plazinska A, Pajak K, Paul RK, Bernier M, Wainer IW, Xiao RP. Tyrosine 308 is necessary for ligand-directed Gs protein-biased signaling of β2-adrenoceptor. The Journal of Biological Chemistry. 289: 19351-63. PMID 24831005 DOI: 10.1074/Jbc.M114.558882 |
0.741 |
|
| 2014 |
Chang YP, Banerjee J, Dowell C, Wu J, Gyanda R, Houghten RA, Toll L, McIntosh JM, Armishaw CJ. Discovery of a potent and selective α3β4 nicotinic acetylcholine receptor antagonist from an α-conotoxin synthetic combinatorial library. Journal of Medicinal Chemistry. 57: 3511-21. PMID 24649848 DOI: 10.1021/Jm500183R |
0.399 |
|
| 2014 |
Plazinska A, Pajak K, Rutkowska E, Jimenez L, Kozocas J, Koolpe G, Tanga M, Toll L, Wainer IW, Jozwiak K. Comparative molecular field analysis of fenoterol derivatives interacting with an agonist-stabilized form of the β₂-adrenergic receptor. Bioorganic & Medicinal Chemistry. 22: 234-46. PMID 24326276 DOI: 10.1016/J.Bmc.2013.11.030 |
0.753 |
|
| 2014 |
Wu J, Perry DC, Bupp JE, Jiang F, Polgar WE, Toll L, Zaveri NT. [¹²⁵I]AT-1012, a new high affinity radioligand for the α3β4 nicotinic acetylcholine receptors. Neuropharmacology. 77: 193-9. PMID 24095990 DOI: 10.1016/J.Neuropharm.2013.09.023 |
0.465 |
|
| 2014 |
Wnorowski A, Paul RK, Jimenez L, Toll L, Kotb A, Bernier M, Wainer IW. Abstract 3680: (R,R')-4′-methoxy-1-naphtylfenoterol inhibits pro-survival signaling, proliferation and motility of select human melanoma cell lines Cancer Research. 74: 3680-3680. DOI: 10.1158/1538-7445.Am2014-3680 |
0.415 |
|
| 2013 |
Wu J, Zhang Y, Maida LE, Santos RG, Welmaker GS, LaVoi TM, Nefzi A, Yu Y, Houghten RA, Toll L, Giulianotti MA. Scaffold ranking and positional scanning utilized in the discovery of nAChR-selective compounds suitable for optimization studies. Journal of Medicinal Chemistry. 56: 10103-17. PMID 24274400 DOI: 10.1021/Jm401543H |
0.369 |
|
| 2013 |
Patkar KA, Wu J, Ganno ML, Singh HD, Ross NC, Rasakham K, Toll L, McLaughlin JP. Physical presence of nor-binaltorphimine in mouse brain over 21 days after a single administration corresponds to its long-lasting antagonistic effect on κ-opioid receptors. The Journal of Pharmacology and Experimental Therapeutics. 346: 545-54. PMID 23853171 DOI: 10.1124/Jpet.113.206086 |
0.342 |
|
| 2013 |
Zaveri NT, Jiang F, Olsen C, Polgar WE, Toll L. Designing bifunctional NOP receptor-mu opioid receptor ligands from NOP receptor-selective scaffolds. Part I. Bioorganic & Medicinal Chemistry Letters. 23: 3308-13. PMID 23623415 DOI: 10.1016/J.Bmcl.2013.03.101 |
0.493 |
|
| 2013 |
Toll L. The use of bifunctional NOP/mu and NOP receptor selective compounds for the treatment of pain, drug abuse, and psychiatric disorders. Current Pharmaceutical Design. 19: 7451-60. PMID 23448477 DOI: 10.2174/13816128113199990354 |
0.467 |
|
| 2013 |
Vazquez-DeRose J, Stauber G, Khroyan TV, Xie XS, Zaveri NT, Toll L. Retrodialysis of N/OFQ into the nucleus accumbens shell blocks cocaine-induced increases in extracellular dopamine and locomotor activity. European Journal of Pharmacology. 699: 200-6. PMID 23219985 DOI: 10.1016/J.Ejphar.2012.11.050 |
0.3 |
|
| 2013 |
Gyanda R, Banerjee J, Chang YP, Phillips AM, Toll L, Armishaw CJ. Oxidative folding and preparation of α-conotoxins for use in high-throughput structure-activity relationship studies. Journal of Peptide Science : An Official Publication of the European Peptide Society. 19: 16-24. PMID 23193084 DOI: 10.1002/Psc.2467 |
0.369 |
|
| 2013 |
Moaddel R, Abdrakhmanova G, Kozak J, Jozwiak K, Toll L, Jimenez L, Rosenberg A, Tran T, Xiao Y, Zarate CA, Wainer IW. Sub-anesthetic concentrations of (R,S)-ketamine metabolites inhibit acetylcholine-evoked currents in α7 nicotinic acetylcholine receptors. European Journal of Pharmacology. 698: 228-34. PMID 23183107 DOI: 10.1016/J.Ejphar.2012.11.023 |
0.666 |
|
| 2012 |
Paul RK, Ramamoorthy A, Scheers J, Wersto RP, Toll L, Jimenez L, Bernier M, Wainer IW. Cannabinoid receptor activation correlates with the proapoptotic action of the β2-adrenergic agonist (R,R')-4-methoxy-1-naphthylfenoterol in HepG2 hepatocarcinoma cells. The Journal of Pharmacology and Experimental Therapeutics. 343: 157-66. PMID 22776956 DOI: 10.1124/Jpet.112.195206 |
0.522 |
|
| 2012 |
Alt C, Lam JS, Harrison MT, Kershaw KM, Samuelsson S, Toll L, D'Andrea A. Nociceptin/orphanin FQ inhibition with SB612111 ameliorates dextran sodium sulfate-induced colitis. European Journal of Pharmacology. 683: 285-93. PMID 22449384 DOI: 10.1016/J.Ejphar.2012.03.014 |
0.311 |
|
| 2012 |
Toll L, Pajak K, Plazinska A, Jozwiak K, Jimenez L, Kozocas JA, Tanga MJ, Bupp JE, Wainer IW. Thermodynamics and docking of agonists to the β(2)-adrenoceptor determined using [(3)H](R,R')-4-methoxyfenoterol as the marker ligand. Molecular Pharmacology. 81: 846-54. PMID 22434858 DOI: 10.1124/Mol.111.077347 |
0.768 |
|
| 2012 |
Toll L, Zaveri NT, Polgar WE, Jiang F, Khroyan TV, Zhou W, Xie XS, Stauber GB, Costello MR, Leslie FM. AT-1001: a high affinity and selective α3β4 nicotinic acetylcholine receptor antagonist blocks nicotine self-administration in rats. Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology. 37: 1367-76. PMID 22278092 DOI: 10.1038/Npp.2011.322 |
0.429 |
|
| 2012 |
Jiang F, Bupp J, Rhee S, Toll L, Zaveri NT. Radiosynthesis of a 125I analog of a highly selective alpha3beta4 nicotinic acetylcholine receptor antagonist ligand for use in autoradiography studies Journal of Labelled Compounds and Radiopharmaceuticals. 55: 177-179. DOI: 10.1002/Jlcr.2923 |
0.437 |
|
| 2011 |
Cami-Kobeci G, Polgar WE, Khroyan TV, Toll L, Husbands SM. Structural determinants of opioid and NOP receptor activity in derivatives of buprenorphine. Journal of Medicinal Chemistry. 54: 6531-7. PMID 21866885 DOI: 10.1021/Jm2003238 |
0.515 |
|
| 2011 |
Khroyan TV, Polgar WE, Orduna J, Montenegro J, Jiang F, Zaveri NT, Toll L. Differential effects of nociceptin/orphanin FQ (NOP) receptor agonists in acute versus chronic pain: studies with bifunctional NOP/μ receptor agonists in the sciatic nerve ligation chronic pain model in mice. The Journal of Pharmacology and Experimental Therapeutics. 339: 687-93. PMID 21859931 DOI: 10.1124/Jpet.111.184663 |
0.432 |
|
| 2011 |
Jozwiak K, Plazinska A, Toll L, Jimenez L, Woo AY, Xiao RP, Wainer IW. Effect of fenoterol stereochemistry on the β2 adrenergic receptor system: ligand-directed chiral recognition. Chirality. 23: E1-6. PMID 21618615 DOI: 10.1002/Chir.20963 |
0.729 |
|
| 2011 |
Donica CL, Ramirez VI, Awwad HO, Zaveri NT, Toll L, Standifer KM. Orphanin FQ/nociceptin activates nuclear factor kappa B. Journal of Neuroimmune Pharmacology : the Official Journal of the Society On Neuroimmune Pharmacology. 6: 617-25. PMID 21547539 DOI: 10.1007/S11481-011-9279-2 |
0.405 |
|
| 2011 |
Khroyan TV, Polgar WE, Cami-Kobeci G, Husbands SM, Zaveri NT, Toll L. The first universal opioid ligand, (2S)-2-[(5R,6R,7R,14S)-N-cyclopropylmethyl-4,5-epoxy-6,14-ethano-3-hydroxy-6-methoxymorphinan-7-yl]-3,3-dimethylpentan-2-ol (BU08028): characterization of the in vitro profile and in vivo behavioral effects in mouse models of acute pain and cocaine-induced reward. The Journal of Pharmacology and Experimental Therapeutics. 336: 952-61. PMID 21177476 DOI: 10.1124/Jpet.110.175620 |
0.521 |
|
| 2011 |
Toll L, Jimenez L, Waleh N, Jozwiak K, Woo AY, Xiao RP, Bernier M, Wainer IW. {Beta}2-adrenergic receptor agonists inhibit the proliferation of 1321N1 astrocytoma cells. The Journal of Pharmacology and Experimental Therapeutics. 336: 524-32. PMID 21071556 DOI: 10.1124/Jpet.110.173971 |
0.709 |
|
| 2011 |
Cami-Kobeci G, Polgar WE, Khroyan TV, Toll L, Husbands SM. Novel ligands interacting with opioid receptors Pharmacological Reports. 63: 210. DOI: 10.1016/S1734-1140(11)70423-6 |
0.475 |
|
| 2010 |
Zaveri N, Jiang F, Olsen C, Polgar W, Toll L. Novel α3β4 nicotinic acetylcholine receptor-selective ligands. Discovery, structure-activity studies, and pharmacological evaluation. Journal of Medicinal Chemistry. 53: 8187-91. PMID 20979364 DOI: 10.1021/Jm1006148 |
0.468 |
|
| 2010 |
Jozwiak K, Toll L, Jimenez L, Woo AY, Xiao RP, Wainer IW. The effect of stereochemistry on the thermodynamic characteristics of the binding of fenoterol stereoisomers to the beta(2)-adrenoceptor. Biochemical Pharmacology. 79: 1610-5. PMID 20144591 DOI: 10.1016/J.Bcp.2010.01.035 |
0.66 |
|
| 2010 |
Jozwiak K, Woo AY, Tanga MJ, Toll L, Jimenez L, Kozocas JA, Plazinska A, Xiao RP, Wainer IW. Comparative molecular field analysis of fenoterol derivatives: A platform towards highly selective and effective beta(2)-adrenergic receptor agonists. Bioorganic & Medicinal Chemistry. 18: 728-36. PMID 20036561 DOI: 10.1016/J.Bmc.2009.11.062 |
0.65 |
|
| 2010 |
Wainer IW, Toll L, Jimenez L, Polgar W, Green C, Gow J, O'Loughlin K, Bernier M. Abstract 724: Selective β2-adrenergic receptor agonists inhibit the proliferation of 1321N1 astrocytoma cells Cancer Research. 70: 724-724. DOI: 10.1158/1538-7445.Am10-724 |
0.496 |
|
| 2009 |
Toll L, Khroyan TV, Polgar WE, Jiang F, Olsen C, Zaveri NT. Comparison of the antinociceptive and antirewarding profiles of novel bifunctional nociceptin receptor/mu-opioid receptor ligands: implications for therapeutic applications. The Journal of Pharmacology and Experimental Therapeutics. 331: 954-64. PMID 19773529 DOI: 10.1124/Jpet.109.157446 |
0.445 |
|
| 2009 |
Khroyan TV, Polgar WE, Jiang F, Zaveri NT, Toll L. Nociceptin/orphanin FQ receptor activation attenuates antinociception induced by mixed nociceptin/orphanin FQ/mu-opioid receptor agonists. The Journal of Pharmacology and Experimental Therapeutics. 331: 946-53. PMID 19713488 DOI: 10.1124/Jpet.109.156711 |
0.55 |
|
| 2009 |
Khroyan TV, Polgar WE, Orduna J, Jiang F, Olsen C, Toll L, Zaveri NT. Activity of new NOP receptor ligands in a rat peripheral mononeuropathy model: potentiation of morphine anti-allodynic activity by NOP receptor antagonists. European Journal of Pharmacology. 610: 49-54. PMID 19285491 DOI: 10.1016/J.Ejphar.2009.03.019 |
0.486 |
|
| 2008 |
Spagnolo B, Calo G, Polgar WE, Jiang F, Olsen CM, Berzetei-Gurske I, Khroyan TV, Husbands SM, Lewis JW, Toll L, Zaveri NT. Activities of mixed NOP and mu-opioid receptor ligands. British Journal of Pharmacology. 153: 609-19. PMID 18059322 DOI: 10.1038/Sj.Bjp.0707598 |
0.431 |
|
| 2007 |
Madrid PB, Polgar WE, Toll L, Tanga MJ. Synthesis and antitubercular activity of phenothiazines with reduced binding to dopamine and serotonin receptors. Bioorganic & Medicinal Chemistry Letters. 17: 3014-7. PMID 17407813 DOI: 10.1016/J.Bmcl.2007.03.064 |
0.39 |
|
| 2007 |
Khroyan TV, Polgar WE, Orduna J, Zaveri NT, Judd AK, Tuttle DJ, Sanchez A, Toll L. Anti-nociceptive and anti-allodynic effects of a high affinity NOP hexapeptide [Ac-RY(3-Cl)YRWR-NH2] (Syn 1020) in rodents. European Journal of Pharmacology. 560: 29-35. PMID 17303110 DOI: 10.1016/J.Ejphar.2006.12.015 |
0.343 |
|
| 2007 |
Khroyan TV, Zaveri NT, Polgar WE, Orduna J, Olsen C, Jiang F, Toll L. SR 16435 [1-(1-(bicyclo[3.3.1]nonan-9-yl)piperidin-4-yl)indolin-2-one], a novel mixed nociceptin/orphanin FQ/mu-opioid receptor partial agonist: analgesic and rewarding properties in mice. The Journal of Pharmacology and Experimental Therapeutics. 320: 934-43. PMID 17132815 DOI: 10.1124/jpet.106.111997 |
0.334 |
|
| 2006 |
Zaveri NT, Waleh N, Toll L. Regulation of the prepronociceptin gene and its effect on neuronal differentiation. Gene. 384: 27-36. PMID 16935438 DOI: 10.1016/J.Gene.2006.07.007 |
0.325 |
|
| 2005 |
Zaveri N, Jiang F, Olsen C, Polgar W, Toll L. Small-molecule agonists and antagonists of the opioid receptor-like receptor (ORL1, NOP): ligand-based analysis of structural factors influencing intrinsic activity at NOP. The Aaps Journal. 7: E345-52. PMID 16353914 DOI: 10.1208/Aapsj070234 |
0.524 |
|
| 2005 |
MacDougall JM, Zhang XD, Polgar WE, Khroyan TV, Toll L, Cashman JR. Synthesis and in vitro biological evaluation of a carbon glycoside analogue of morphine-6-glucuronide. Bioorganic & Medicinal Chemistry Letters. 15: 1583-6. PMID 15745801 DOI: 10.1016/J.Bmcl.2005.01.072 |
0.458 |
|
| 2004 |
MacDougall JM, Zhang XD, Polgar WE, Khroyan TV, Toll L, Cashman JR. Design, chemical synthesis, and biological evaluation of thiosaccharide analogues of morphine- and codeine-6-glucuronide. Journal of Medicinal Chemistry. 47: 5809-15. PMID 15509180 DOI: 10.1021/Jm049554T |
0.4 |
|
| 2004 |
Macdougall JM, Zhang XD, Polgar WE, Khroyan TV, Toll L, Cashman JR. Synthesis and biological evaluation of some 6-arylamidomorphines as analogues of morphine-6-glucuronide. Bioorganic & Medicinal Chemistry. 12: 5983-90. PMID 15498674 DOI: 10.1016/J.Bmc.2004.08.019 |
0.471 |
|
| 2004 |
Choi S, Haggart D, Toll L, Cuny GD. Synthesis, receptor binding and functional studies of mesoridazine stereoisomers. Bioorganic & Medicinal Chemistry Letters. 14: 4379-82. PMID 15357957 DOI: 10.1016/J.Bmcl.2004.06.078 |
0.466 |
|
| 2004 |
Zaveri NT, Jiang F, Olsen CM, Deschamps JR, Parrish D, Polgar W, Toll L. A novel series of piperidin-4-yl-1,3-dihydroindol-2-ones as agonist and antagonist ligands at the nociceptin receptor. Journal of Medicinal Chemistry. 47: 2973-6. PMID 15163178 DOI: 10.1021/Jm034249D |
0.52 |
|
| 2004 |
Jong L, Zaveri N, Toll L. The design and synthesis of a novel quinolizidine template for potent opioid and opioid receptor-like (ORL1, NOP) receptor ligands. Bioorganic & Medicinal Chemistry Letters. 14: 181-5. PMID 14684324 DOI: 10.1016/J.Bmcl.2003.09.068 |
0.513 |
|
| 2002 |
Zaveri NT, Green CJ, Polgar WE, Huynh N, Toll L. Regulation of transcription of the human prepronociceptin gene by Sp1. Gene. 290: 45-52. PMID 12062800 DOI: 10.1016/S0378-1119(02)00565-6 |
0.301 |
|
| 2001 |
Zaveri N, Polgar WE, Olsen CM, Kelson AB, Grundt P, Lewis JW, Toll L. Characterization of opiates, neuroleptics, and synthetic analogs at ORL1 and opioid receptors. European Journal of Pharmacology. 428: 29-36. PMID 11779034 DOI: 10.1016/S0014-2999(01)01282-1 |
0.537 |
|
| 2001 |
Dawson MI, Park JH, Chen G, Chao W, Dousman L, Waleh N, Hobbs PD, Jong L, Toll L, Zhang X, Gu J, Agadir A, Merchant JL, Bai L, Verma AK, et al. Retinoic acid (RA) receptor transcriptional activation correlates with inhibition of 12-O-tetradecanoylphorbol-13-acetate-induced ornithine decarboxylase (ODC) activity by retinoids: a potential role for trans-RA-induced ZBP-89 in ODC inhibition. International Journal of Cancer. Journal International Du Cancer. 91: 8-21. PMID 11149424 DOI: 10.1002/1097-0215(20010101)91:1<8::Aid-Ijc1007>3.0.Co;2-H |
0.376 |
|
| 2000 |
Burnside JL, Rodriguez L, Toll L. Species differences in the efficacy of compounds at the nociceptin receptor (ORL1) Peptides. 21: 1147-1154. PMID 10998550 DOI: 10.1016/S0196-9781(00)00253-9 |
0.477 |
|
| 2000 |
Coop A, Norton CL, Berzetei-Gurske I, Burnside J, Toll L, Husbands SM, Lewis JW. Structural determinants of opioid activity in the orvinols and related structures: ethers of orvinol and isoorvinol. Journal of Medicinal Chemistry. 43: 1852-7. PMID 10794701 DOI: 10.1021/Jm990951R |
0.508 |
|
| 2000 |
Coop A, Berzetei-Gurske I, Burnside J, Toll L, Traynor JR, Husbands SM, Lewis JW. Structural determinants of opioid activity in the orvinols and related structures. Ethers of 7,8-cyclopenta-fused analogs of buprenorphine Helvetica Chimica Acta. 83: 687-693. DOI: 10.1002/(Sici)1522-2675(20000412)83:4<687::Aid-Hlca687>3.0.Co;2-W |
0.421 |
|
| 1997 |
Adapa ID, Toll L. Relationship between binding affinity and functional activity of nociceptin/orphanin FQ Neuropeptides. 31: 403-408. PMID 9413015 DOI: 10.1016/S0143-4179(97)90032-9 |
0.445 |
|
| 1997 |
Gintzler AR, Adapa ID, Toll L, Medina VM, Wang L. Modulation of enkephalin release by nociceptin (orphanin FQ). European Journal of Pharmacology. 325: 29-34. PMID 9151935 DOI: 10.1016/S0014-2999(97)00103-9 |
0.438 |
|
| 1997 |
Toll L, Polgar WE, Auh JS. Characterization of the δ-opioid receptor found in SH-SY5Y neuroblastoma cells European Journal of Pharmacology. 323: 261-267. PMID 9128848 DOI: 10.1016/S0014-2999(97)00031-9 |
0.514 |
|
| 1996 |
Ciszewska GR, Ginos JA, Charton M, Standifer KM, Brooks AI, Brown GP, Ryan-Moro JP, Berzetei-Gurske I, Toll L, Pasternak GW. Synthesis and characterization of substituted benzoylhydrazones of naloxone. Synapse (New York, N.Y.). 24: 193-201. PMID 8890461 DOI: 10.1002/(Sici)1098-2396(199610)24:2<193::Aid-Syn11>3.0.Co;2-# |
0.524 |
|
| 1996 |
Berzetei-Gurske IP, Schwartz RW, Toll L. Determination of activity for nociceptin in the mouse vas deferens European Journal of Pharmacology. 302. PMID 8791013 DOI: 10.1016/0014-2999(96)00238-5 |
0.408 |
|
| 1996 |
Polgar WE, Bitler CM, Toll L. Desensitization of melanotropin receptors in COS-7 cells Life Sciences. 58: 1223-1229. PMID 8614275 DOI: 10.1016/0024-3205(96)00083-5 |
0.459 |
|
| 1995 |
Meunier JC, Mollereau C, Toll L, Suaudeau C, Moisand C, Aivinerie P, Butour JL, Guillemot JC, Ferrara P, Monsarrat B, Mazarguil H, Vassart G, Parmentler M, Costentin J. Isolation and structure of the endogenous agonist of opioid receptor-like ORL1 receptor Nature. 377: 532-X. PMID 7566152 DOI: 10.1038/377532A0 |
0.491 |
|
| 1995 |
Berzetei-Gurske IP, White A, Polgar W, DeCosta BR, Pasternak GW, Toll L. The in vitro pharmacological characterization of naloxone benzoylhydrazone European Journal of Pharmacology. 277: 257-263. PMID 7493617 DOI: 10.1016/0014-2999(95)00088-3 |
0.495 |
|
| 1994 |
Morhenn VB, Waleh NS, Mansbridge JN, Unson D, Zolotorev A, Cline P, Toll L. Evidence for an NMDA receptor subunit in human keratinocytes and rat cardiocytes. European Journal of Pharmacology. 268: 409-14. PMID 7805765 DOI: 10.1016/0922-4106(94)90066-3 |
0.429 |
|
| 1994 |
Toll L, Polgar WE, Auh JS. Characterization of the δ receptor subtype in SH-SY5Y neuroblastoma cells Regulatory Peptides. 54: 303-304. DOI: 10.1016/0167-0115(94)90510-X |
0.446 |
|
| 1993 |
Webster JL, Polgar WE, Brandt SR, Berzetei-Gurske IP, Toll L. Comparison of κ2-opioid receptors in guinea pig brain and guinea pig ileum membranes European Journal of Pharmacology. 231: 251-258. PMID 8095898 DOI: 10.1016/0014-2999(93)90457-S |
0.457 |
|
| 1993 |
Perez JJ, Villar HO, Uyeno E, Toll L, Olsen C, Polgar W, Loew GH. Molecular determinants of recognition and activation at the μ-opioid receptor by met-enkephalin-like peptides International Journal of Quantum Chemistry. 48: 147-160. DOI: 10.1002/Qua.560480717 |
0.435 |
|
| 1992 |
Berzetei-Gurske IP, Toll L. The μ-opioid activity of κ-opioid receptor agonist compounds in the guinea pig ileum European Journal of Pharmacology. 212: 283-286. PMID 1318215 DOI: 10.1016/0014-2999(92)90345-5 |
0.474 |
|
| 1991 |
Lawson J, Toll L, Polgar W, Uyeno E, Loew G. Structure-activity studies of morphine fragments. III. Synthesis, opiate receptor binding, analgetic activity and conformational studies of spiro-[tetralin-1,4′-piperidines] European Journal of Medicinal Chemistry. 26: 775-785. DOI: 10.1016/0223-5234(91)90003-6 |
0.471 |
|
| 1991 |
Loew G, Lawson J, Toll L, Polgar W, Uyeno E. Structure-activity studies of morphine fragments. II. Synthesis, opiate receptor binding, analgetic activity and conformational studies of 2-R-2(hydroxybenzyl)piperidines European Journal of Medicinal Chemistry. 26: 763-773. DOI: 10.1016/0223-5234(91)90002-5 |
0.517 |
|
| 1990 |
Toll L. μ-Opioid receptor binding in intact SH-SY5Y neuroblastoma cells European Journal of Pharmacology. 176: 213-217. PMID 1968847 DOI: 10.1016/0014-2999(90)90530-J |
0.544 |
|
| 1988 |
Lawson JA, Cheng A, DeGraw J, Frenking G, Uyeno E, Toll L, Loew GH. Effects of addition of a 2-methyl group to ethyl nipecotates (β-meperidines) on receptor affinities and opiate agonist/antagonist activities Journal of Medicinal Chemistry. 31: 2015-2021. PMID 2845084 DOI: 10.1021/Jm00118A028 |
0.437 |
|
| 1986 |
Toll L, Almquist RG. Inhibition of [3H]captopril binding by peptide analog angiotensin converting enzyme inhibitors. Biochemical and Biophysical Research Communications. 135: 770-777. PMID 3008745 DOI: 10.1016/0006-291X(86)90995-2 |
0.339 |
|
| 1986 |
Cheng A, Uyeno E, Polgar W, Toll L, Lawson JA, DeGraw JI, Loew G, Camerman A, Camerman N. N-substituent modulation of opiate agonist/antagonist activity in resolved 3-methyl-3-(m-hydroxyphenyl)piperidines. Journal of Medicinal Chemistry. 29: 531-537. PMID 3007760 DOI: 10.1021/Jm00154A018 |
0.491 |
|
| 1986 |
Cheng A, Uyeno E, Polgar W, Toll L, Lawson JA, Degraw JI, Loew G, Camerman A, Camerman N. N‐Substituted Modulation of Opiate Agonist/Antagonist Activity in Resolved 3‐Methyl‐3‐(m‐hydroxyphenyl)piperidines. Cheminform. 17. DOI: 10.1002/Chin.198649197 |
0.412 |
|
| 1984 |
Toll L, Keys C, Spangler D, Loew G. Computer-assisted determination of benzodiazepine receptor heterogeneity European Journal of Pharmacology. 99: 203-209. PMID 6329782 DOI: 10.1016/0014-2999(84)90242-5 |
0.523 |
|
| 1984 |
Lawson JA, Uyeno ET, Nienow J, Loew GH, Toll L. Structure-activity studies of β-carboline analogs Life Sciences. 34: 2007-2013. PMID 6328151 DOI: 10.1016/0024-3205(84)90365-5 |
0.556 |
|
| 1984 |
Almquist RG, Olsen CM, Uyeno ET, Toll L. Replacement of the peptide-backbone amides connecting Tyr-Gly and Gly-Gly in leucine-enkephalin with ketomethylene groups: synthesis and biological activity. Journal of Medicinal Chemistry. 27: 115-20. PMID 6319699 DOI: 10.1021/Jm00368A003 |
0.372 |
|
| 1984 |
Loew G, Toll L, Lawson J, Uyeno E, Kaegi H. Pyrazolo[1,5-a]pyrimidines: receptor binding and anxiolytic behavioral studies. Pharmacology, Biochemistry and Behavior. 20: 343-348. PMID 6143325 DOI: 10.1016/0091-3057(84)90268-5 |
0.487 |
|
| 1984 |
Toll L, Keys C, Polgar W, Loew G. The use of computer analysis in describing multiple opiate receptors Neuropeptides. 5: 205-208. PMID 6099498 DOI: 10.1016/0143-4179(84)90063-5 |
0.38 |
|
| 1983 |
Toll L, Keys C, Loew G. Detailed receptor binding studies of a series of N-substituted ethyl 3-arylnipecotates. Life Sciences. 33: 427-430. PMID 6319897 DOI: 10.1016/0024-3205(83)90533-7 |
0.544 |
|
| 1983 |
Leow GH, Toll L, Keys C. Computer-assisted analysis of receptor-binding studies of [3H]-naloxone and [3H]-DADL: A reinterpretation of the Na+ effect Life Sciences. 33: 163-166. PMID 6319855 DOI: 10.1016/0024-3205(83)90469-1 |
0.492 |
|
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