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Frances Wiseman, MRes, PhD - Related publications

2018- UCL Institute of Neurology, Queen Square, London, England, United Kingdom 
Ageing, Neuroscience, Down Syndrome, Alzheimer’s disease, Genetics
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50 most relevant papers in past 60 days:
Year Citation  Score
2020 Gomez W, Morales R, Maracaja-Coutinho V, Parra V, Nassif M. Down syndrome and Alzheimer's disease: common molecular traits beyond the amyloid precursor protein. Aging. 11. PMID 31918411 DOI: 10.18632/aging.102677   
2020 Yan T, Liang J, Gao J, Wang L, Fujioka H, , Zhu X, Wang X. FAM222A encodes a protein which accumulates in plaques in Alzheimer's disease. Nature Communications. 11: 411. PMID 31964863 DOI: 10.1038/s41467-019-13962-0   
2020 Zhang W, Luo P. Myocardial Infarction Predisposes Neurodegenerative Diseases. Journal of Alzheimer's Disease : Jad. PMID 32065796 DOI: 10.3233/JAD-191225   
2020 Zhu Q, Zhang N, Hu N, Jiang R, Lu H, Xuan A, Long D, Chen Y. Neural stem cell transplantation improves learning and memory by protecting cholinergic neurons and restoring synaptic impairment in an amyloid precursor protein/presenilin 1 transgenic mouse model of Alzheimer's disease. Molecular Medicine Reports. PMID 31922229 DOI: 10.3892/mmr.2020.10918   
2020 Chintapaludi SR, Uyar A, Jackson HM, Acklin CJ, Wang X, Sasner M, Carter GW, Howell GR. Staging Alzheimer's Disease in the Brain and Retina of B6.APP/PS1 Mice by Transcriptional Profiling. Journal of Alzheimer's Disease : Jad. PMID 31929156 DOI: 10.3233/JAD-190793   
2020 Guyot AC, Leuxe C, Disdier C, Oumata N, Costa N, Roux GL, Fernandez-Varela P, Duchon A, Charbonnier JB, Herault Y, Pavoni S, Galons H, Andriambeloson E, Wagner S, Meijer L, et al. A Small Compound Targeting Prohibitin with Potential Interest for Cognitive Deficit Rescue in Aging mice and Tau Pathology Treatment. Scientific Reports. 10: 1143. PMID 31980673 DOI: 10.1038/s41598-020-57560-3   
2020 Bharadwaj P, Martins RN. PRKAG2 Gene Expression Is Elevated and its Protein Levels Are Associated with Increased Amyloid-β Accumulation in the Alzheimer's Disease Brain. Journal of Alzheimer's Disease : Jad. PMID 32039845 DOI: 10.3233/JAD-190948   
2020 Jeon Y, Lee JH, Choi B, Won SY, Cho KS. Genetic Dissection of Alzheimer's Disease Using Models. International Journal of Molecular Sciences. 21. PMID 32019113 DOI: 10.3390/ijms21030884   
2020 Meilandt WJ, Ngu H, Gogineni A, Lalehzadeh G, Lee SH, Srinivasan K, Imperio J, Wu T, Weber M, Kruse AJ, Stark KL, Chan P, Kwong M, Modrusan Z, Friedman BA, et al. Trem2 deletion reduces late-stage amyloid plaque accumulation, elevates the Aβ42:Aβ40 ratio, and exacerbates axonal dystrophy and dendritic spine loss in the PS2APP Alzheimer's mouse model. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. PMID 31980586 DOI: 10.1523/JNEUROSCI.1871-19.2019   
2020 Raman S, Brookhouser N, Brafman DA. Using human induced pluripotent stem cells (hiPSCs) to investigate the mechanisms by which Apolipoprotein E (APOE) contributes to Alzheimer's disease (AD) risk. Neurobiology of Disease. 104788. PMID 32032733 DOI: 10.1016/j.nbd.2020.104788   
2020 Li L, Qiu Y, Miao M, Liu Z, Li W, Zhu Y, Wang Q. Reduction of Tet2 exacerbates early stage Alzheimer's pathology and cognitive impairments in 2 × Tg-ad mice. Human Molecular Genetics. PMID 31943063 DOI: 10.1093/hmg/ddz282   
2020 Patel H, Iniesta R, Stahl D, Dobson RJB, Newhouse SJ. Working Towards a Blood-Derived Gene Expression Biomarker Specific for Alzheimer's Disease. Journal of Alzheimer's Disease : Jad. PMID 32065794 DOI: 10.3233/JAD-191163   
2020 Iturria-Medina Y, Khan AF, Adewale Q, Shirazi AH, . Blood and brain gene expression trajectories mirror neuropathology and clinical deterioration in neurodegeneration. Brain : a Journal of Neurology. PMID 31989163 DOI: 10.1093/brain/awz400   
2020 Cohen D, Pilozzi A, Huang X. Network Medicine Approach for Analysis of Alzheimer's Disease Gene Expression Data. International Journal of Molecular Sciences. 21. PMID 31947790 DOI: 10.3390/ijms21010332   
2020 Wang H, Li Q, Sun S, Chen S. Neuroprotective Effects of Salidroside in a Mouse Model of Alzheimer's Disease. Cellular and Molecular Neurobiology. PMID 32002777 DOI: 10.1007/s10571-020-00801-w   
2020 Chen C, Xu D, Zhang ZH, Jia SZ, Cao XC, Chen YB, Song GL, Wong MS, Li HW. Cognitive improvement and synaptic deficit attenuation by a multifunctional carbazole-based cyanine in AD mice model through regulation of Ca/CaMKII/CREB signaling pathway. Experimental Neurology. 113210. PMID 31987831 DOI: 10.1016/j.expneurol.2020.113210   
2020 Ikezu S, Ingraham Dixie KL, Koro L, Watanabe T, Kaibuchi K, Ikezu T. Tau-tubulin kinase 1 and amyloid-β peptide induce phosphorylation of collapsin response mediator protein-2 and enhance neurite degeneration in Alzheimer disease mouse models. Acta Neuropathologica Communications. 8: 12. PMID 32019603 DOI: 10.1186/s40478-020-0890-4   
2020 Kim H, Kim B, Kim HS, Cho JY. Nicotinamide attenuates the decrease in dendritic spine density in hippocampal primary neurons from 5xFAD mice, an Alzheimer's disease animal model. Molecular Brain. 13: 17. PMID 32033569 DOI: 10.1186/s13041-020-0565-x   
2020 Li J, Zhao R, Jiang Y, Xu Y, Zhao H, Lyu X, Wu T. Bilberry anthocyanins improve neuroinflammation and cognitive dysfunction in APP/PSEN1 mice via the CD33/TREM2/TYROBP signaling pathway in microglia. Food & Function. PMID 32003387 DOI: 10.1039/c9fo02103e   
2020 Wang M, Peng IF, Li S, Hu X. Dysregulation of antimicrobial peptide expression distinguishes Alzheimer's disease from normal aging. Aging. 12. PMID 31907335 DOI: 10.18632/aging.102650   
2020 Ye JY, Li L, Hao QM, Qin Y, Ma CS. β-Sitosterol treatment attenuates cognitive deficits and prevents amyloid plaque deposition in amyloid protein precursor/presenilin 1 mice. The Korean Journal of Physiology & Pharmacology : Official Journal of the Korean Physiological Society and the Korean Society of Pharmacology. 24: 39-46. PMID 31908573 DOI: 10.4196/kjpp.2020.24.1.39   
2020 Whyte LS, Hassiotis S, Hattersley KJ, Hemsley KM, Hopwood JJ, Lau AA, Sargeant TJ. Lysosomal dysregulation in the murine App model of Alzheimer's disease. Neuroscience. PMID 31917339 DOI: 10.1016/j.neuroscience.2019.12.042   
2020 Dong Y, Stewart T, Bai L, Li X, Xu T, Iliff J, Shi M, Zheng D, Yuan L, Wei T, Yang X, Zhang J. Coniferaldehyde attenuates Alzheimer's pathology activation of Nrf2 and its targets. Theranostics. 10: 179-200. PMID 31903114 DOI: 10.7150/thno.36722   
2020 Castanho I, Murray TK, Hannon E, Jeffries A, Walker E, Laing E, Baulf H, Harvey J, Bradshaw L, Randall A, Moore K, O'Neill P, Lunnon K, Collier DA, Ahmed Z, et al. Transcriptional Signatures of Tau and Amyloid Neuropathology. Cell Reports. 30: 2040-2054.e5. PMID 32049030 DOI: 10.1016/j.celrep.2020.01.063   
2020 Li Y, Wang Y, Wang J, Chong KY, Xu J, Liu Z, Shan C. Expression of Neprilysin in Skeletal Muscle by Ultrasound-Mediated Gene Transfer (Sonoporation) Reduces Amyloid Burden for AD. Molecular Therapy. Methods & Clinical Development. 17: 300-308. PMID 32021878 DOI: 10.1016/j.omtm.2019.12.012   
2020 Iyaswamy A, Krishnamoorthi SK, Song JX, Yang CB, Kaliyamoorthy V, Zhang H, Sreenivasmurthy SG, Malampati S, Wang ZY, Zhu Z, Tong BC, Cheung KH, Lu JH, Durairajan SSK, Li M. NeuroDefend, a novel Chinese medicine, attenuates amyloid-β and tau pathology in experimental Alzheimer's disease models. Journal of Food and Drug Analysis. 28: 132-146. PMID 31883601 DOI: 10.1016/j.jfda.2019.09.004   
2020 Shen H, Guan Q, Zhang X, Yuan C, Tan Z, Zhai L, Hao Y, Gu Y, Han C. New mechanism of neuroinflammation in Alzheimer's disease: The activation of NLRP3 inflammasome mediated by gut microbiota. Progress in Neuro-Psychopharmacology & Biological Psychiatry. 109884. PMID 32032696 DOI: 10.1016/j.pnpbp.2020.109884   
2020 Evans CE, Miners JS, Piva G, Willis CL, Heard DM, Kidd EJ, Good MA, Kehoe PG. ACE2 activation protects against cognitive decline and reduces amyloid pathology in the Tg2576 mouse model of Alzheimer's disease. Acta Neuropathologica. PMID 31982938 DOI: 10.1007/s00401-019-02098-6   
2020 Borreca A, Valeri F, De Luca M, Ernst L, Russo A, Nobili A, Cordella A, Corsetti V, Amadoro G, Mercuri NB, D'Amelio M, Ammassari-Teule M. Transient upregulation of translational efficiency in prodromal and early symptomatic Tg2576 mice contributes to Aβ pathology. Neurobiology of Disease. 104787. PMID 32032729 DOI: 10.1016/j.nbd.2020.104787   
2020 Borreca A, Valeri F, De Luca M, Ernst L, Russo A, Nobili A, Cordella A, Corsetti V, Amadoro G, Mercuri NB, D'Amelio M, Ammassari-Teule M. Transient upregulation of translational efficiency in prodromal and early symptomatic Tg2576 mice contributes to Aβ pathology. Neurobiology of Disease. 104787. PMID 32032729 DOI: 10.1016/j.nbd.2020.104787   
2020 Krishnamurthy K, Cantillana V, Wang H, Sullivan PM, Kolls BJ, Ge X, Lin Y, Mace B, Laskowitz DT. ApoE mimetic improves pathology and memory in a model of Alzheimer's disease. Brain Research. 146685. PMID 32007397 DOI: 10.1016/j.brainres.2020.146685   
2020 Cannavo C, Tosh J, Fisher EMC, Wiseman FK. Using mouse models to understand Alzheimer's disease mechanisms in the context of trisomy of chromosome 21. Progress in Brain Research. 251: 181-208. PMID 32057307 DOI: 10.1016/bs.pbr.2019.10.004   
2020 Wen J, Zhao M, Liu L. Expression of Oatp2 in the Brain and Liver of Alzheimer Disease Mouse Model. Acs Chemical Neuroscience. PMID 31967785 DOI: 10.1021/acschemneuro.9b00636   
2020 Roy ER, Wang B, Wan YW, Chiu GS, Cole AL, Yin Z, Propson NE, Xu Y, Jankowsky JL, Liu Z, Lee VM, Trojanowski JQ, Ginsberg SD, Butovsky O, Zheng H, et al. Type I interferon response drives neuroinflammation and synapse loss in Alzheimer disease. The Journal of Clinical Investigation. PMID 31917687 DOI: 10.1172/JCI133737   
2020 Li L, Wu XH, Zhao XJ, Xu L, Pan CL, Zhang ZY. Zerumbone ameliorates behavioral impairments and neuropathology in transgenic APP/PS1 mice by suppressing MAPK signaling. Journal of Neuroinflammation. 17: 61. PMID 32066466 DOI: 10.1186/s12974-020-01744-1   
2020 Lee SB, Yang SY, Thao NP, Seo DG, Kim S, Ma CT, Park SY, Kim YH, Yang HO. Protective Effects of Compounds from against Amyloid Beta Production in Vitro and Scopolamine-Induced Memory Impairment in Vivo. Journal of Natural Products. PMID 32031796 DOI: 10.1021/acs.jnatprod.9b00543   
2020 Fernando WMADB, Martins IJ, Morici M, Bharadwaj P, Rainey-Smith SR, Lim WLF, Martins RN. Sodium Butyrate Reduces Brain Amyloid-β Levels and Improves Cognitive Memory Performance in an Alzheimer's Disease Transgenic Mouse Model at an Early Disease Stage. Journal of Alzheimer's Disease : Jad. PMID 31958090 DOI: 10.3233/JAD-190120   
2020 Fernando WMADB, Martins IJ, Morici M, Bharadwaj P, Rainey-Smith SR, Lim WLF, Martins RN. Sodium Butyrate Reduces Brain Amyloid-β Levels and Improves Cognitive Memory Performance in an Alzheimer's Disease Transgenic Mouse Model at an Early Disease Stage. Journal of Alzheimer's Disease : Jad. PMID 31958090 DOI: 10.3233/JAD-190120   
2020 Zhao N, Attrebi ON, Ren Y, Qiao W, Sonustun B, Martens YA, Meneses AD, Li F, Shue F, Zheng J, Van Ingelgom AJ, Davis MD, Kurti A, Knight JA, Linares C, et al. APOE4 exacerbates α-synuclein pathology and related toxicity independent of amyloid. Science Translational Medicine. 12. PMID 32024798 DOI: 10.1126/scitranslmed.aay1809   
2020 Woerman AL, Patel S, Kazmi SA, Oehler A, Lee J, Mordes DA, Olson SH, Prusiner SB. Kinetics of α-synuclein prions preceding neuropathological inclusions in multiple system atrophy. Plos Pathogens. 16: e1008222. PMID 32017806 DOI: 10.1371/journal.ppat.1008222   
2020 Wu Y, Gong Y, Luan Y, Li Y, Liu J, Yue Z, Yuan B, Sun J, Xie C, Li L, Zhen J, Jin X, Zheng Y, Wang X, Xie L, et al. BHBA treatment improves cognitive function by targeting pleiotropic mechanisms in transgenic mouse model of Alzheimer's disease. Faseb Journal : Official Publication of the Federation of American Societies For Experimental Biology. 34: 1412-1429. PMID 31914599 DOI: 10.1096/fj.201901984R   
2020 Lazic D, Tesic V, Jovanovic M, Brkic M, Milanovic D, Zlokovic BV, Kanazir S, Perovic M. Every-other-day feeding exacerbates inflammation and neuronal deficits in 5XFAD mouse model of Alzheimer's disease. Neurobiology of Disease. 136: 104745. PMID 31931140 DOI: 10.1016/j.nbd.2020.104745   
2020 Gadhave K, Gehi BR, Kumar P, Xue B, Uversky VN, Giri R. The dark side of Alzheimer's disease: unstructured biology of proteins from the amyloid cascade signaling pathway. Cellular and Molecular Life Sciences : Cmls. PMID 31894361 DOI: 10.1007/s00018-019-03414-9   
2020 King CD, Robinson RAS. Evaluating cPILOT Performance on Orbitraps to Study the Peripheral Proteome of Alzheimer's Disease. Analytical Chemistry. PMID 31940168 DOI: 10.1021/acs.analchem.9b01974   
2020 Du Y, Fu M, Huang Z, Tian X, Li J, Pang Y, Song W, Tian Wang Y, Dong Z. TRPV1 activation alleviates cognitive and synaptic plasticity impairments through inhibiting AMPAR endocytosis in APP23/PS45 mouse model of Alzheimer's disease. Aging Cell. e13113. PMID 32061032 DOI: 10.1111/acel.13113   
2020 Du Y, Liu X, Zhu X, Liu Y, Wang X, Wu X. Activating Transcription Factor 6 reduces Aβ1-42 and restores memory in Alzheimer's disease model mice. The International Journal of Neuroscience. 1-11. PMID 31928492 DOI: 10.1080/00207454.2020.1715977   
2020 Zhang M, Chen W, Zong Y, Shi K, Li J, Zeng F, He Z, Du R. Cognitive-enhancing effects of fibrauretine on Aβ-induced Alzheimer's disease by compatibilization with ginsenosides. Neuropeptides. 102020. PMID 31982159 DOI: 10.1016/j.npep.2020.102020   
2020 Sierksma A, Lu A, Mancuso R, Fattorelli N, Thrupp N, Salta E, Zoco J, Blum D, Buée L, De Strooper B, Fiers M. Novel Alzheimer risk genes determine the microglia response to amyloid-β but not to TAU pathology. Embo Molecular Medicine. e10606. PMID 31951107 DOI: 10.15252/emmm.201910606   
2020 Butterfield DA, Mattson MP. Apolipoprotein E and oxidative stress in brain with relevance to Alzheimer's disease. Neurobiology of Disease. 104795. PMID 32036033 DOI: 10.1016/j.nbd.2020.104795   
2020 Svensson M, Andersson E, Manouchehrian O, Yang Y, Deierborg T. Voluntary running does not reduce neuroinflammation or improve non-cognitive behavior in the 5xFAD mouse model of Alzheimer's disease. Scientific Reports. 10: 1346. PMID 31992814 DOI: 10.1038/s41598-020-58309-8