Hiroyuki Hosokawa - Publications

Affiliations: 
2018 California Institute of Technology, Pasadena, CA 

60 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2022 Koizumi M, Kama Y, Hirano KI, Endo Y, Tanaka T, Hozumi K, Hosokawa H. Transcription factor Zbtb1 interacts with bridging factor Lmo2 and maintains the T-lineage differentiation capacity of lymphoid progenitor cells. The Journal of Biological Chemistry. 102506. PMID 36126774 DOI: 10.1016/j.jbc.2022.102506  0.522
2022 Hirano KI, Hosokawa H, Yahata T, Ando K, Tanaka M, Imai J, Yazawa M, Ohtsuka M, Negishi N, Habu S, Sato T, Hozumi K. Dll1 Can Function as a Ligand of Notch1 and Notch2 in the Thymic Epithelium. Frontiers in Immunology. 13: 852427. PMID 35371023 DOI: 10.3389/fimmu.2022.852427  0.451
2021 Hirano KI, Hosokawa H, Koizumi M, Endo Y, Yahata T, Ando K, Hozumi K. LMO2 is essential to maintain the ability of progenitors to differentiate into T-cell lineage in mice. Elife. 10. PMID 34382935 DOI: 10.7554/eLife.68227  0.523
2021 Hosokawa H, Koizumi M, Masuhara K, Romero-Wolf M, Tanaka T, Nakayama T, Rothenberg EV. Stage-specific action of Runx1 and GATA3 controls silencing of PU.1 expression in mouse pro-T cells. The Journal of Experimental Medicine. 218. PMID 34180951 DOI: 10.1084/jem.20202648  0.757
2021 Yazawa M, Hosokawa H, Koizumi M, Hrano KI, Imai J, Hozumi K. Notch signaling supports the appearance of follicular helper T cells in the Peyer's patches concomitantly with the reduction of regulatory T cells. International Immunology. PMID 34147033 DOI: 10.1093/intimm/dxab032  0.522
2021 Hosokawa H, Masuhara K, Koizumi M. Transcription factors regulate early T cell development via redeployment of other factors: Functional dynamics of constitutively required factors in cell fate decisions. Bioessays : News and Reviews in Molecular, Cellular and Developmental Biology. 43: e2000345. PMID 33624856 DOI: 10.1002/bies.202000345  0.558
2021 Shin B, Hosokawa H, Romero-Wolf M, Zhou W, Masuhara K, Tobin VR, Levanon D, Groner Y, Rothenberg EV. Runx1 and Runx3 drive progenitor to T-lineage transcriptome conversion in mouse T cell commitment via dynamic genomic site switching. Proceedings of the National Academy of Sciences of the United States of America. 118. PMID 33479171 DOI: 10.1073/pnas.2019655118  0.824
2020 Hosokawa H, Rothenberg EV. How transcription factors drive choice of the T cell fate. Nature Reviews. Immunology. PMID 32918063 DOI: 10.1038/S41577-020-00426-6  0.781
2020 Masuhara K, Akatsuka H, Tokusanai M, Li C, Iida Y, Okada Y, Suzuki T, Ohtsuka M, Inoue I, Kimura M, Hosokawa H, Hozumi K, Sato T. AMBRA1 controls antigen-driven activation and proliferation of naïve T cells. International Immunology. PMID 32909612 DOI: 10.1093/intimm/dxaa063  0.447
2020 Romero-Wolf M, Shin B, Zhou W, Koizumi M, Rothenberg EV, Hosokawa H. Notch2 complements Notch1 to mediate inductive signaling that initiates early T cell development. The Journal of Cell Biology. 219. PMID 32756905 DOI: 10.1083/Jcb.202005093  0.796
2019 Hosokawa H, Romero-Wolf M, Yang Q, Motomura Y, Levanon D, Groner Y, Moro K, Tanaka T, Rothenberg EV. Cell type-specific actions of Bcl11b in early T-lineage and group 2 innate lymphoid cells. The Journal of Experimental Medicine. PMID 31653691 DOI: 10.1084/Jem.20190972  0.74
2019 Rothenberg EV, Hosokawa H, Ungerbäck J. Mechanisms of Action of Hematopoietic Transcription Factor PU.1 in Initiation of T-Cell Development. Frontiers in Immunology. 10: 228. PMID 30842770 DOI: 10.3389/Fimmu.2019.00228  0.836
2018 Hosokawa H, Romero-Wolf M, Yui MA, Ungerbäck J, Quiloan MLG, Matsumoto M, Nakayama KI, Tanaka T, Rothenberg EV. Bcl11b sets pro-T cell fate by site-specific cofactor recruitment and by repressing Id2 and Zbtb16. Nature Immunology. 19: 1427-1440. PMID 30374131 DOI: 10.1038/S41590-018-0238-4  0.811
2018 Tanaka K, Kanesaka Y, Takami M, Suzuki A, Hosokawa H, Onodera A, Kamata T, Nagato K, Nakayama T, Yoshino I, Motohashi S. Role of leukotriene B4 12-hydroxydehydrogenase in α-galactosylceramide-pulsed dendritic cell therapy for non-small cell lung cancer. Biochemical and Biophysical Research Communications. PMID 30336981 DOI: 10.1016/J.Bbrc.2018.10.048  0.463
2018 Hosokawa H, Ungerbäck J, Wang X, Matsumoto M, Nakayama KI, Cohen SM, Tanaka T, Rothenberg EV. Transcription Factor PU.1 Represses and Activates Gene Expression in Early T Cells by Redirecting Partner Transcription Factor Binding. Immunity. 49: 782. PMID 30332634 DOI: 10.1016/J.Immuni.2018.09.019  0.825
2018 Ungerbäck J, Hosokawa H, Wang X, Strid T, Williams BA, Sigvardsson M, Rothenberg EV. Pioneering, chromatin remodeling, and epigenetic constraint in early T-cell gene regulation by SPI1 (PU.1). Genome Research. PMID 30171019 DOI: 10.1101/Gr.231423.117  0.803
2018 Hosokawa H, Ungerbäck J, Wang X, Matsumoto M, Nakayama KI, Cohen SM, Tanaka T, Rothenberg EV. Transcription Factor PU.1 Represses and Activates Gene Expression in Early T Cells by Redirecting Partner Transcription Factor Binding. Immunity. 48: 1119-1134.e7. PMID 29924977 DOI: 10.1016/J.Immuni.2018.04.024  0.822
2018 Rothenberg E, Hosokawa H, Romero-Wolf M, Wang X, Zhou W, Ungerbäck J. Regulation of genomic activity in T-lymphocyte development by dynamic transcription factor ensembles Experimental Hematology. 64: S30-S31. DOI: 10.1016/J.Exphem.2018.06.021  0.796
2017 Hosokawa H, Rothenberg EV. Cytokines, Transcription Factors, and the Initiation of T-Cell Development. Cold Spring Harbor Perspectives in Biology. PMID 28716889 DOI: 10.1101/Cshperspect.A028621  0.778
2017 Longabaugh WJR, Zeng W, Zhang JA, Hosokawa H, Jansen CS, Li L, Romero-Wolf M, Liu P, Kueh HY, Mortazavi A, Rothenberg EV. Bcl11b and combinatorial resolution of cell fate in the T-cell gene regulatory network. Proceedings of the National Academy of Sciences of the United States of America. 114: 5800-5807. PMID 28584128 DOI: 10.1073/Pnas.1610617114  0.826
2017 Nakayama T, Hirahara K, Onodera A, Endo Y, Hosokawa H, Shinoda K, Tumes DJ, Okamoto Y. Th2 Cells in Health and Disease. Annual Review of Immunology. 35: 53-84. PMID 27912316 DOI: 10.1146/Annurev-Immunol-051116-052350  0.392
2016 Hayashizaki K, Kimura MY, Tokoyoda K, Hosokawa H, Shinoda K, Hirahara K, Ichikawa T, Onodera A, Hanazawa A, Iwamura C, Kakuta J, Muramoto K, Motohashi S, Tumes DJ, Iinuma T, et al. Myosin light chains 9 and 12 are functional ligands for CD69 that regulate airway inflammation. Science Immunology. 1: eaaf9154. PMID 28783682 DOI: 10.1126/Sciimmunol.Aaf9154  0.346
2016 Hosokawa H, Tanaka T, Endo Y, Kato M, Shinoda K, Suzuki A, Motohashi S, Matsumoto M, Nakayama KI, Nakayama T. Akt1-mediated Gata3 phosphorylation controls the repression of IFNγ in memory-type Th2 cells. Nature Communications. 7: 11289. PMID 27053161 DOI: 10.1038/Ncomms11289  0.389
2015 Hosokawa H, Kato M, Tohyama H, Tamaki Y, Endo Y, Kimura MY, Tumes DJ, Motohashi S, Matsumoto M, Nakayama KI, Tanaka T, Nakayama T. Methylation of gata3 protein at arg-261 regulates transactivation of the il5 gene in T helper 2 cells. The Journal of Biological Chemistry. 290: 13095-103. PMID 25861992 DOI: 10.1074/Jbc.M114.621524  0.463
2014 Mishima Y, Wang C, Miyagi S, Saraya A, Hosokawa H, Mochizuki-Kashio M, Nakajima-Takagi Y, Koide S, Negishi M, Sashida G, Naito T, Ishikura T, Onodera A, Nakayama T, Tenen DG, et al. Histone acetylation mediated by Brd1 is crucial for Cd8 gene activation during early thymocyte development. Nature Communications. 5: 5872. PMID 25519988 DOI: 10.1182/Blood.V124.21.1576.1576  0.349
2013 Tumes DJ, Onodera A, Suzuki A, Shinoda K, Endo Y, Iwamura C, Hosokawa H, Koseki H, Tokoyoda K, Suzuki Y, Motohashi S, Nakayama T. The polycomb protein Ezh2 regulates differentiation and plasticity of CD4(+) T helper type 1 and type 2 cells. Immunity. 39: 819-32. PMID 24238339 DOI: 10.1016/J.Immuni.2013.09.012  0.568
2013 Hosokawa H, Tanaka T, Kato M, Shinoda K, Tohyama H, Hanazawa A, Tamaki Y, Hirahara K, Yagi R, Sakikawa I, Morita A, Nagira M, Poyurovsky MV, Suzuki Y, Motohashi S, et al. Gata3/Ruvbl2 complex regulates T helper 2 cell proliferation via repression of Cdkn2c expression. Proceedings of the National Academy of Sciences of the United States of America. 110: 18626-31. PMID 24167278 DOI: 10.1073/Pnas.1311100110  0.536
2013 Sasaki T, Onodera A, Hosokawa H, Watanabe Y, Horiuchi S, Yamashita J, Tanaka H, Ogawa Y, Suzuki Y, Nakayama T. Genome-Wide Gene Expression Profiling Revealed a Critical Role for GATA3 in the Maintenance of the Th2 Cell Identity. Plos One. 8: e66468. PMID 23824597 DOI: 10.1371/Journal.Pone.0066468  0.477
2013 Hosokawa H, Tanaka T, Suzuki Y, Iwamura C, Ohkubo S, Endoh K, Kato M, Endo Y, Onodera A, Tumes DJ, Kanai A, Sugano S, Nakayama T. Functionally distinct Gata3/Chd4 complexes coordinately establish T helper 2 (Th2) cell identity. Proceedings of the National Academy of Sciences of the United States of America. 110: 4691-6. PMID 23471993 DOI: 10.1073/Pnas.1220865110  0.536
2013 Sasaki T, Onodera A, Hosokawa H, Watanabe Y, Horiuchi S, Yamashita J, Tanaka H, Ogawa Y, Suzuki Y, Nakayama T. The effects of GATA3 knockdown on the gene expression of Th2-1 st , Th2-4 th and memory Th2 cells. Plos One. DOI: 10.1371/Journal.Pone.0066468.G006  0.34
2012 Kuwahara M, Yamashita M, Shinoda K, Tofukuji S, Onodera A, Shinnakasu R, Motohashi S, Hosokawa H, Tumes D, Iwamura C, Lefebvre V, Nakayama T. The transcription factor Sox4 is a downstream target of signaling by the cytokine TGF-β and suppresses T(H)2 differentiation. Nature Immunology. 13: 778-86. PMID 22751141 DOI: 10.1038/Ni.2362  0.589
2012 Lavial F, Bessonnard S, Ohnishi Y, Tsumura A, Chandrashekran A, Fenwick MA, Tomaz RA, Hosokawa H, Nakayama T, Chambers I, Hiiragi T, Chazaud C, Azuara V. Bmi1 facilitates primitive endoderm formation by stabilizing Gata6 during early mouse development. Genes & Development. 26: 1445-58. PMID 22713603 DOI: 10.1101/Gad.188193.112  0.411
2012 Shinoda K, Tokoyoda K, Hanazawa A, Hayashizaki K, Zehentmeier S, Hosokawa H, Iwamura C, Koseki H, Tumes DJ, Radbruch A, Nakayama T. Type II membrane protein CD69 regulates the formation of resting T-helper memory. Proceedings of the National Academy of Sciences of the United States of America. 109: 7409-14. PMID 22474373 DOI: 10.1073/Pnas.1118539109  0.352
2012 Inamine A, Sakurai D, Horiguchi S, Yonekura S, Hanazawa T, Hosokawa H, Matuura-Suzuki A, Nakayama T, Okamoto Y. Sublingual administration of Lactobacillus paracasei KW3110 inhibits Th2-dependent allergic responses via upregulation of PD-L2 on dendritic cells. Clinical Immunology (Orlando, Fla.). 143: 170-9. PMID 22386865 DOI: 10.1016/J.Clim.2012.01.008  0.306
2012 Yamashita J, Iwamura C, Mitsumori K, Hosokawa H, Sasaki T, Takahashi M, Tanaka H, Kaneko K, Hanazawa A, Watanabe Y, Shinoda K, Tumes D, Motohashi S, Nakayama T. Murine Schnurri-2 controls natural killer cell function and lymphoma development. Leukemia & Lymphoma. 53: 479-86. PMID 21936769 DOI: 10.3109/10428194.2011.625099  0.409
2011 Endo Y, Iwamura C, Kuwahara M, Suzuki A, Sugaya K, Tumes DJ, Tokoyoda K, Hosokawa H, Yamashita M, Nakayama T. Eomesodermin controls interleukin-5 production in memory T helper 2 cells through inhibition of activity of the transcription factor GATA3. Immunity. 35: 733-45. PMID 22118525 DOI: 10.1016/J.Immuni.2011.08.017  0.436
2011 Horiuchi S, Onodera A, Hosokawa H, Watanabe Y, Tanaka T, Sugano S, Suzuki Y, Nakayama T. Genome-wide analysis reveals unique regulation of transcription of Th2-specific genes by GATA3. Journal of Immunology (Baltimore, Md. : 1950). 186: 6378-89. PMID 21536806 DOI: 10.4049/Jimmunol.1100179  0.529
2010 Onodera A, Yamashita M, Endo Y, Kuwahara M, Tofukuji S, Hosokawa H, Kanai A, Suzuki Y, Nakayama T. STAT6-mediated displacement of polycomb by trithorax complex establishes long-term maintenance of GATA3 expression in T helper type 2 cells. The Journal of Experimental Medicine. 207: 2493-506. PMID 20956546 DOI: 10.1084/Jem.20100760  0.544
2010 Suzuki S, Tanaka T, Poyurovsky MV, Nagano H, Mayama T, Ohkubo S, Lokshin M, Hosokawa H, Nakayama T, Suzuki Y, Sugano S, Sato E, Nagao T, Yokote K, Tatsuno I, et al. Phosphate-activated glutaminase (GLS2), a p53-inducible regulator of glutamine metabolism and reactive oxygen species. Proceedings of the National Academy of Sciences of the United States of America. 107: 7461-6. PMID 20351271 DOI: 10.1073/Pnas.1002459107  0.306
2010 Suzuki A, Iwamura C, Shinoda K, Tumes DJ, Kimura MY, Hosokawa H, Endo Y, Horiuchi S, Tokoyoda K, Koseki H, Yamashita M, Nakayama T. Polycomb group gene product Ring1B regulates Th2-driven airway inflammation through the inhibition of Bim-mediated apoptosis of effector Th2 cells in the lung. Journal of Immunology (Baltimore, Md. : 1950). 184: 4510-20. PMID 20237291 DOI: 10.4049/Jimmunol.0903426  0.483
2009 Miki-Hosokawa T, Hasegawa A, Iwamura C, Shinoda K, Tofukuji S, Watanabe Y, Hosokawa H, Motohashi S, Hashimoto K, Shirai M, Yamashita M, Nakayama T. CD69 controls the pathogenesis of allergic airway inflammation. Journal of Immunology (Baltimore, Md. : 1950). 183: 8203-15. PMID 19923457 DOI: 10.4049/Jimmunol.0900646  0.326
2009 Kitajima M, Iwamura C, Miki-Hosokawa T, Shinoda K, Endo Y, Watanabe Y, Shinnakasu R, Hosokawa H, Hashimoto K, Motohashi S, Koseki H, Ohara O, Yamashita M, Nakayama T. Enhanced Th2 cell differentiation and allergen-induced airway inflammation in Zfp35-deficient mice. Journal of Immunology (Baltimore, Md. : 1950). 183: 5388-96. PMID 19783676 DOI: 10.4049/Jimmunol.0804155  0.357
2009 Nagata A, Tanaka T, Minezawa A, Poyurovsky M, Mayama T, Suzuki S, Hashimoto N, Yoshida T, Suyama K, Miyata A, Hosokawa H, Nakayama T, Tatsuno I. cAMP activation by PACAP/VIP stimulates IL-6 release and inhibits osteoblastic differentiation through VPAC2 receptor in osteoblastic MC3T3 cells. Journal of Cellular Physiology. 221: 75-83. PMID 19496170 DOI: 10.1002/Jcp.21831  0.343
2008 Shinnakasu R, Yamashita M, Kuwahara M, Hosokawa H, Hasegawa A, Motohashi S, Nakayama T. Gfi1-mediated stabilization of GATA3 protein is required for Th2 cell differentiation. The Journal of Biological Chemistry. 283: 28216-25. PMID 18701459 DOI: 10.1074/Jbc.M804174200  0.544
2008 Ito T, Hasegawa A, Hosokawa H, Yamashita M, Motohashi S, Naka T, Okamoto Y, Fujita Y, Ishii Y, Taniguchi M, Yano I, Nakayama T. Human Th1 differentiation induced by lipoarabinomannan/lipomannan from Mycobacterium bovis BCG Tokyo-172. International Immunology. 20: 849-60. PMID 18469327 DOI: 10.1093/Intimm/Dxn043  0.485
2008 Hossain MB, Hosokawa H, Hasegawa A, Watarai H, Taniguchi M, Yamashita M, Nakayama T. Lymphoid enhancer factor interacts with GATA-3 and controls its function in T helper type 2 cells. Immunology. 125: 377-86. PMID 18445004 DOI: 10.1111/J.1365-2567.2008.02854.X  0.59
2008 Yamashita M, Kuwahara M, Suzuki A, Hirahara K, Shinnaksu R, Hosokawa H, Hasegawa A, Motohashi S, Iwama A, Nakayama T. Bmi1 regulates memory CD4 T cell survival via repression of the Noxa gene. The Journal of Experimental Medicine. 205: 1109-20. PMID 18411339 DOI: 10.1084/Jem.20072000  0.449
2007 Nakano N, Hosokawa H, Kohyama M, Hozumi N. NF-AT-mediated expression of TGF-beta1 in tolerant T cells. Journal of Immunology (Baltimore, Md. : 1950). 178: 3067-75. PMID 17312153 DOI: 10.4049/jimmunol.178.5.3067  0.389
2007 Kaneko T, Hosokawa H, Yamashita M, Wang CR, Hasegawa A, Kimura MY, Kitajiama M, Kimura F, Miyazaki M, Nakayama T. Chromatin remodeling at the Th2 cytokine gene loci in human type 2 helper T cells. Molecular Immunology. 44: 2249-56. PMID 17166591 DOI: 10.1016/J.Molimm.2006.11.004  0.446
2006 Hosokawa H, Kimura MY, Shinnakasu R, Suzuki A, Miki T, Koseki H, van Lohuizen M, Yamashita M, Nakayama T. Regulation of Th2 cell development by Polycomb group gene bmi-1 through the stabilization of GATA3. Journal of Immunology (Baltimore, Md. : 1950). 177: 7656-64. PMID 17114435 DOI: 10.4049/Jimmunol.177.11.7656  0.493
2006 Shinnakasu R, Yamashita M, Shinoda K, Endo Y, Hosokawa H, Hasegawa A, Ikemizu S, Nakayama T. Critical YxKxHxxxRP motif in the C-terminal region of GATA3 for its DNA binding and function. Journal of Immunology (Baltimore, Md. : 1950). 177: 5801-10. PMID 17056504 DOI: 10.4049/Jimmunol.177.9.5801  0.446
2006 Yamashita M, Hirahara K, Shinnakasu R, Hosokawa H, Norikane S, Kimura MY, Hasegawa A, Nakayama T. Crucial role of MLL for the maintenance of memory T helper type 2 cell responses. Immunity. 24: 611-22. PMID 16713978 DOI: 10.1016/J.Immuni.2006.03.017  0.459
2006 Hasegawa A, Miki T, Hosokawa H, Hossain MB, Shimizu C, Hashimoto K, Kimura MY, Yamashita M, Nakayama T. Impaired GATA3-dependent chromatin remodeling and Th2 cell differentiation leading to attenuated allergic airway inflammation in aging mice. Journal of Immunology (Baltimore, Md. : 1950). 176: 2546-54. PMID 16456016 DOI: 10.4049/Jimmunol.176.4.2546  0.463
2006 Yamashita M, Hirahara K, Hosokawa H, Nakayama T. S3e1-3 Epigenetic regulation of memory Th2 cell generation(S3-e1: "Dynamic Features in Immune System",Symposia,Abstract,Meeting Program of EABS & BSJ 2006) Seibutsu Butsuri. 46: S137. DOI: 10.2142/Biophys.46.S137_2  0.317
2005 Kimura MY, Hosokawa H, Yamashita M, Hasegawa A, Iwamura C, Watarai H, Taniguchi M, Takagi T, Ishii S, Nakayama T. Regulation of T helper type 2 cell differentiation by murine Schnurri-2. The Journal of Experimental Medicine. 201: 397-408. PMID 15699073 DOI: 10.1084/Jem.20040733  0.569
2004 Katsumoto T, Kimura M, Yamashita M, Hosokawa H, Hashimoto K, Hasegawa A, Omori M, Miyamoto T, Taniguchi M, Nakayama T. STAT6-dependent differentiation and production of IL-5 and IL-13 in murine NK2 cells. Journal of Immunology (Baltimore, Md. : 1950). 173: 4967-75. PMID 15470039 DOI: 10.4049/Jimmunol.173.8.4967  0.377
2004 Yamashita M, Ukai-Tadenuma M, Miyamoto T, Sugaya K, Hosokawa H, Hasegawa A, Kimura M, Taniguchi M, DeGregori J, Nakayama T. Essential role of GATA3 for the maintenance of type 2 helper T (Th2) cytokine production and chromatin remodeling at the Th2 cytokine gene loci. The Journal of Biological Chemistry. 279: 26983-90. PMID 15087456 DOI: 10.1074/Jbc.M403688200  0.455
2003 Omori M, Yamashita M, Inami M, Ukai-Tadenuma M, Kimura M, Nigo Y, Hosokawa H, Hasegawa A, Taniguchi M, Nakayama T. CD8 T cell-specific downregulation of histone hyperacetylation and gene activation of the IL-4 gene locus by ROG, repressor of GATA. Immunity. 19: 281-94. PMID 12932361 DOI: 10.1016/S1074-7613(03)00210-3  0.464
2003 Murata K, Inami M, Hasegawa A, Kubo S, Kimura M, Yamashita M, Hosokawa H, Nagao T, Suzuki K, Hashimoto K, Shinkai H, Koseki H, Taniguchi M, Ziegler SF, Nakayama T. CD69-null mice protected from arthritis induced with anti-type II collagen antibodies. International Immunology. 15: 987-92. PMID 12882836 DOI: 10.1093/Intimm/Dxg102  0.318
2002 Toda M, Kasai M, Hosokawa H, Nakano N, Taniguchi Y, Inouye S, Kaminogawa S, Takemori T, Sakaguchi M. DNA vaccine using invariant chain gene for delivery of CD4+ T cell epitope peptide derived from Japanese cedar pollen allergen inhibits allergen-specific IgE response. European Journal of Immunology. 32: 1631-9. PMID 12115646 DOI: 10.1002/1521-4141(200206)32:6<1631::Aid-Immu1631>3.0.Co;2-O  0.4
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