Year |
Citation |
Score |
2019 |
Bollinger E, Siddall CP, Greizer T, Libera JL, Hariri G, Pashos EE, Shipstone A, Hadjipanayis A, Sun Z, Xing G, Clasquin MF, Zhang BB, Miller RA, Flach RR. 1922-P: Branched-Chain Ketoacid Dehydrogenase Kinase Inhibition Acutely Improves Glycemia and Alters the Response to Feeding in Mice Diabetes. 68. DOI: 10.2337/Db19-1922-P |
0.306 |
|
2018 |
Ryder T, Calabrese MF, Walker GS, Cameron KO, Reyes AR, Borzilleri KA, Delmore J, Miller RA, Kurumbail RG, Ward J, Kung DW, Brown JA, Edmonds DJ, Eng H, Wolford AC, et al. Acyl Glucuronide Metabolites of 6-Chloro-5-[4-(1-hydroxycyclobutyl)phenyl]-1H-indole-3-carboxylic Acid (PF-06409577) and Related Indole-3-carboxylic Acid Derivatives are Direct Activators of Adenosine Monophosphate-activated Protein Kinase (AMPK). Journal of Medicinal Chemistry. PMID 30036059 DOI: 10.1021/Acs.Jmedchem.8B00807 |
0.341 |
|
2018 |
Miller RA, Shi Y, Lu W, Pirman DA, Jatkar A, Blatnik M, Wu H, Cárdenas C, Wan M, Foskett JK, Park JO, Zhang Y, Holland WL, Rabinowitz JD, Birnbaum MJ. Targeting hepatic glutaminase activity to ameliorate hyperglycemia. Nature Medicine. PMID 29578539 DOI: 10.1038/Nm.4514 |
0.345 |
|
2017 |
Cokorinos EC, Delmore J, Reyes AR, Albuquerque B, Kjøbsted R, Jørgensen NO, Tran JL, Jatkar A, Cialdea K, Esquejo RM, Meissen J, Calabrese MF, Cordes J, Moccia R, Tess D, ... ... Miller RA, et al. Activation of Skeletal Muscle AMPK Promotes Glucose Disposal and Glucose Lowering in Non-human Primates and Mice. Cell Metabolism. 25: 1147-1159.e10. PMID 28467931 DOI: 10.1016/J.Cmet.2017.04.010 |
0.334 |
|
2017 |
Salatto CT, Miller RA, Cameron KO, Cokorinos E, Reyes A, Ward J, Calabrese M, Kurumbail R, Rajamohan F, Kalgutkar AS, Tess DA, Shavnya A, Genung NE, Edmonds DJ, Jatkar A, et al. Selective Activation of AMPK b1-containing Isoforms Improves Kidney Function in a Rat Model of Diabetic Nephropathy. The Journal of Pharmacology and Experimental Therapeutics. PMID 28289077 DOI: 10.1124/Jpet.116.237925 |
0.339 |
|
2016 |
Cameron KO, Kung DW, Kalgutkar AS, Kurumbail RG, Miller R, Salatto CT, Ward J, Withka JM, Bhattacharya SK, Boehm M, Borzilleri KA, Brown JA, Calabrese M, Caspers NL, Cokorinos E, et al. Discovery and Preclinical Characterization of 6-Chloro-5-[4-(1-hydroxycyclobutyl)phenyl]-1H-indole-3-carboxylic Acid (PF-06409577), a Direct Activator of Adenosine Monophosphate-activated Protein Kinase (AMPK), for the Potential Treatment of Diabetic Nephropathy. Journal of Medicinal Chemistry. PMID 27490827 DOI: 10.1021/Acs.Jmedchem.6B00866 |
0.35 |
|
2014 |
Calabrese MF, Rajamohan F, Harris MS, Caspers NL, Magyar R, Withka JM, Wang H, Borzilleri KA, Sahasrabudhe PV, Hoth LR, Geoghegan KF, Han S, Brown J, Subashi TA, Reyes AR, ... ... Miller RA, et al. Structural basis for AMPK activation: natural and synthetic ligands regulate kinase activity from opposite poles by different molecular mechanisms. Structure (London, England : 1993). 22: 1161-72. PMID 25066137 DOI: 10.1016/J.Str.2014.06.009 |
0.396 |
|
2013 |
Miller RA, Chu Q, Xie J, Foretz M, Viollet B, Birnbaum MJ. Biguanides suppress hepatic glucagon signalling by decreasing production of cyclic AMP. Nature. 494: 256-60. PMID 23292513 DOI: 10.1038/Nature11808 |
0.39 |
|
2011 |
Miller RA, Chu Q, Le Lay J, Scherer PE, Ahima RS, Kaestner KH, Foretz M, Viollet B, Birnbaum MJ. Adiponectin suppresses gluconeogenic gene expression in mouse hepatocytes independent of LKB1-AMPK signaling. The Journal of Clinical Investigation. 121: 2518-28. PMID 21606593 DOI: 10.1172/Jci45942 |
0.326 |
|
2011 |
Holland WL, Miller RA, Wang ZV, Sun K, Barth BM, Bui HH, Davis KE, Bikman BT, Halberg N, Rutkowski JM, Wade MR, Tenorio VM, Kuo MS, Brozinick JT, Zhang BB, et al. Receptor-mediated activation of ceramidase activity initiates the pleiotropic actions of adiponectin. Nature Medicine. 17: 55-63. PMID 21186369 DOI: 10.1038/Nm.2277 |
0.315 |
|
2010 |
Miller RA, Birnbaum MJ. An energetic tale of AMPK-independent effects of metformin. The Journal of Clinical Investigation. 120: 2267-70. PMID 20577046 DOI: 10.1172/Jci43661 |
0.342 |
|
2009 |
Miller RA. Ligand-regulated peptide aptamers. Methods in Molecular Biology (Clifton, N.J.). 535: 315-31. PMID 19377988 DOI: 10.1007/978-1-59745-557-2_18 |
0.566 |
|
2007 |
Miller RA, Binkowski BF, Belshaw PJ. Ligand-regulated peptide aptamers that inhibit the 5'-AMP-activated protein kinase. Journal of Molecular Biology. 365: 945-57. PMID 17116308 DOI: 10.1016/J.Jmb.2006.07.035 |
0.617 |
|
2005 |
Binkowski BF, Miller RA, Belshaw PJ. Ligand-regulated peptides: a general approach for modulating protein-peptide interactions with small molecules. Chemistry & Biology. 12: 847-55. PMID 16039531 DOI: 10.1016/J.Chembiol.2005.05.021 |
0.611 |
|
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