| Year |
Citation |
Score |
| 2023 |
Beckley JT, Aman TK, Ackley MA, Kazdoba TM, Lewis MC, Smith AC, Farley BJ, Dai J, Deats W, Hoffmann E, Robichaud AJ, Doherty JJ, Quirk MC. Pharmacological characterization of SAGE-718, a novel NMDA receptor positive allosteric modulator. British Journal of Pharmacology. PMID 37698384 DOI: 10.1111/bph.16235 |
0.398 |
|
| 2023 |
Tang W, Beckley JT, Zhang J, Song R, Xu Y, Kim S, Quirk MC, Robichaud AJ, Diaz ES, Myers SJ, Doherty JJ, Ackley MA, Traynelis SF, Yuan H. Novel neuroactive steroids as positive allosteric modulators of NMDA receptors: mechanism, site of action, and rescue pharmacology on GRIN variants associated with neurological conditions. Cellular and Molecular Life Sciences : Cmls. 80: 42. PMID 36645496 DOI: 10.1007/s00018-022-04667-7 |
0.671 |
|
| 2020 |
Althaus AL, Ackley MA, Belfort GM, Gee SM, Dai J, Nguyen DP, Kazdoba TM, Modgil A, Davies PA, Moss SJ, Salituro FG, Hoffmann E, Hammond RS, Robichaud AJ, Quirk MC, ... Doherty JJ, et al. Preclinical characterization of zuranolone (SAGE-217), a selective neuroactive steroid GABA receptor positive allosteric modulator. Neuropharmacology. 108333. PMID 32976892 DOI: 10.1016/j.neuropharm.2020.108333 |
0.343 |
|
| 2020 |
Mannara F, Radosevic M, Planagumà J, Soto D, Aguilar E, García-Serra A, Maudes E, Pedreño M, Paul S, Doherty J, Quirk M, Dai J, Gasull X, Lewis M, Dalmau J. Allosteric modulation of NMDA receptors prevents the antibody effects of patients with anti-NMDAR encephalitis. Brain : a Journal of Neurology. PMID 32830245 DOI: 10.1093/Brain/Awaa195 |
0.304 |
|
| 2019 |
La DS, Salituro FG, Martinez Botella G, Griffin A, Bai Z, Ackley M, Dai J, Doherty J, Harrison B, Hoffman E, Kazdoba T, Lewis M, Quirk M, Robichaud A. Neuroactive Steroid N-Methyl-D-aspartate Receptor (NMDAR) Positive Allosteric Modulators: Synthesis, SAR and Pharmacological Activity. Journal of Medicinal Chemistry. PMID 31390523 DOI: 10.1021/acs.jmedchem.9b00591 |
0.377 |
|
| 2018 |
Warikoo N, Brunwasser SJ, Benz A, Shu HJ, Paul SM, Lewis M, Doherty J, Quick M, Piccio L, Zorumski CF, Day GS, Mennerick S. Positive allosteric modulation as a potential therapeutic strategy in anti-NMDA receptor encephalitis. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. PMID 29476014 DOI: 10.1523/Jneurosci.3377-17.2018 |
0.378 |
|
| 2017 |
Althaus AL, McCarren HS, Alqazzaz A, Jackson C, McDonough JH, Smith CD, Hoffman E, Hammond RS, Robichaud AJ, Doherty JJ. The synthetic neuroactive steroid SGE-516 reduces status epilepticus and neuronal cell death in a rat model of soman intoxication. Epilepsy & Behavior : E&B. 68: 22-30. PMID 28109985 DOI: 10.1016/j.yebeh.2016.12.024 |
0.339 |
|
| 2015 |
Martin BS, Martinez-Botella G, Loya CM, Salituro FG, Robichaud AJ, Huntsman MM, Ackley MA, Doherty JJ, Corbin JG. Rescue of deficient amygdala tonic γ-aminobutyric acidergic currents in the Fmr(-/y) mouse model of fragile X syndrome by a novel γ-aminobutyric acid type A receptor-positive allosteric modulator. Journal of Neuroscience Research. PMID 26308557 DOI: 10.1002/Jnr.23632 |
0.315 |
|
| 2014 |
Linsenbardt AJ, Taylor A, Emnett CM, Doherty JJ, Krishnan K, Covey DF, Paul SM, Zorumski CF, Mennerick S. Different oxysterols have opposing actions at N-methyl-D-aspartate receptors. Neuropharmacology. 85: 232-42. PMID 24878244 DOI: 10.1016/J.Neuropharm.2014.05.027 |
0.311 |
|
| 2014 |
Martinez-Botella G, Ackley MA, Salituro FG, Doherty JJ. Natural and synthetic neuroactive steroid modulators of GABAA and NMDA receptors Annual Reports in Medicinal Chemistry. 49: 27-42. DOI: 10.1016/B978-0-12-800167-7.00003-1 |
0.363 |
|
| 2013 |
Paul SM, Doherty JJ, Robichaud AJ, Belfort GM, Chow BY, Hammond RS, Crawford DC, Linsenbardt AJ, Shu HJ, Izumi Y, Mennerick SJ, Zorumski CF. The major brain cholesterol metabolite 24(S)-hydroxycholesterol is a potent allosteric modulator of N-methyl-D-aspartate receptors. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 33: 17290-300. PMID 24174662 DOI: 10.1523/Jneurosci.2619-13.2013 |
0.409 |
|
| 2013 |
Georgievska B, Sandin J, Doherty J, Mörtberg A, Neelissen J, Andersson A, Gruber S, Nilsson Y, Schött P, Arvidsson PI, Hellberg S, Osswald G, Berg S, Fälting J, Bhat RV. AZD1080, a novel GSK3 inhibitor, rescues synaptic plasticity deficits in rodent brain and exhibits peripheral target engagement in humans. Journal of Neurochemistry. 125: 446-56. PMID 23410232 DOI: 10.1111/Jnc.12203 |
0.341 |
|
| 2011 |
Zysk JR, Widzowski D, Sygowski LA, Knappenberger KS, Spear N, Elmore CS, Dorff P, Liu H, Doherty J, Chhajlani V. Absence of direct effects on the dopamine D2 receptor by mGluR2/3-selective receptor agonists LY 354,740 and LY 379,268. Synapse (New York, N.Y.). 65: 64-8. PMID 20506301 DOI: 10.1002/Syn.20817 |
0.379 |
|
| 2009 |
Shirey JK, Brady AE, Jones PJ, Davis AA, Bridges TM, Kennedy JP, Jadhav SB, Menon UN, Xiang Z, Watson ML, Christian EP, Doherty JJ, Quirk MC, Snyder DH, Lah JJ, et al. A selective allosteric potentiator of the M1 muscarinic acetylcholine receptor increases activity of medial prefrontal cortical neurons and restores impairments in reversal learning. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 29: 14271-86. PMID 19906975 DOI: 10.1523/Jneurosci.3930-09.2009 |
0.303 |
|
| 2004 |
Doherty JJ, Alagarsamy S, Bough KJ, Conn PJ, Dingledine R, Mott DD. Metabotropic glutamate receptors modulate feedback inhibition in a developmentally regulated manner in rat dentate gyrus. The Journal of Physiology. 561: 395-401. PMID 15513941 DOI: 10.1113/jphysiol.2004.074930 |
0.666 |
|
| 2003 |
Doherty J, Dingledine R. Functional interactions between cannabinoid and metabotropic glutamate receptors in the central nervous system. Current Opinion in Pharmacology. 3: 46-53. PMID 12550741 DOI: 10.1016/S1471-4892(02)00014-0 |
0.628 |
|
| 2002 |
Doherty J, Dingledine R. The roles of metabotropic glutamate receptors in seizures and epilepsy. Current Drug Targets. Cns and Neurological Disorders. 1: 251-60. PMID 12769618 DOI: 10.2174/1568007023339355 |
0.564 |
|
| 2002 |
Huang Y, Doherty JJ, Dingledine R. Altered histone acetylation at glutamate receptor 2 and brain-derived neurotrophic factor genes is an early event triggered by status epilepticus. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 22: 8422-8. PMID 12351716 DOI: 10.1523/Jneurosci.22-19-08422.2002 |
0.656 |
|
| 2001 |
Doherty J, Dingledine R. Reduced excitatory drive onto interneurons in the dentate gyrus after status epilepticus. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 21: 2048-57. PMID 11245688 DOI: 10.1523/Jneurosci.21-06-02048.2001 |
0.649 |
|
| 2000 |
Dingledine R, Doherty J. Genomics and epilepsy research in the new millenium Acta Neurologica Scandinavica, Supplement. 102: 9-10. DOI: 10.1034/J.1600-0404.2000.00202-4.X |
0.464 |
|
| 1999 |
Laezza F, Doherty JJ, Dingledine R. Long-term depression in hippocampal interneurons: joint requirement for pre- and postsynaptic events. Science (New York, N.Y.). 285: 1411-4. PMID 10464102 DOI: 10.1126/Science.285.5432.1411 |
0.696 |
|
| 1998 |
Mott DD, Doherty JJ, Zhang S, Washburn MS, Fendley MJ, Lyuboslavsky P, Traynelis SF, Dingledine R. Phenylethanolamines inhibit NMDA receptors by enhancing proton inhibition. Nature Neuroscience. 1: 659-67. PMID 10196581 DOI: 10.1038/3661 |
0.681 |
|
| 1998 |
Doherty J, Dingledine R. Differential regulation of synaptic inputs to dentate hilar border interneurons by metabotropic glutamate receptors. Journal of Neurophysiology. 79: 2903-10. PMID 9636096 DOI: 10.1152/Jn.1998.79.6.2903 |
0.642 |
|
| 1997 |
Doherty J, Dingledine R. Regulation of excitatory input to inhibitory interneurons of the dentate gyrus during hypoxia. Journal of Neurophysiology. 77: 393-404. PMID 9120580 DOI: 10.1152/Jn.1997.77.1.393 |
0.653 |
|
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