Patrik Rorsman - Publications

Affiliations: 
University of Oxford, Oxford, United Kingdom 
Area:
Pancreatic beta cells

285 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2022 Spiliotis II, Chalk R, Gough S, Rorsman P. Reducing hyperglucagonemia in type 2 diabetes using low dose Glibenclamide: Results of the LEGEND-A pilot study. Diabetes, Obesity & Metabolism. PMID 35491519 DOI: 10.1111/dom.14740  0.306
2022 Veprik A, Denwood G, Liu D, Bany Bakar R, Morfin V, McHugh K, Tebeka NN, Vetterli L, Yonova-Doing E, Gribble F, Reimann F, Hoehn KL, Hemsley PA, Ahnfelt-Rønne J, Rorsman P, et al. Acetyl-CoA-carboxylase 1 (ACC1) plays a critical role in glucagon secretion. Communications Biology. 5: 238. PMID 35304577 DOI: 10.1038/s42003-022-03170-w  0.427
2021 Kim A, Knudsen JG, Madara JC, Benrick A, Hill T, Abdul-Kadir L, Kellard JA, Mellander L, Miranda C, Lin H, James T, Suba K, Spigelman AF, Wu Y, Macdonald PE, ... ... Rorsman P, et al. Arginine-vasopressin mediates counter-regulatory glucagon release and is diminished in type 1 diabetes. Elife. 10. PMID 34787082 DOI: 10.7554/eLife.72919  0.43
2020 Hatamie A, Ren L, Dou H, Gandasi NR, Rorsman P, Ewing AG. Nanoscale amperometry reveals only a fraction of vesicular serotonin content is released during exocytosis from beta cells. Angewandte Chemie (International Ed. in English). PMID 33340209 DOI: 10.1002/anie.202015902  0.352
2020 Oduori OS, Murao N, Shimomura K, Takahashi H, Zhang Q, Dou H, Sakai S, Minami K, Chanclon B, Guida C, Kothegala L, Tolö J, Maejima Y, Yokoi N, Minami Y, ... Rorsman P, et al. Gs/Gq signaling switch in β cells defines incretin effectiveness in diabetes. The Journal of Clinical Investigation. PMID 33196462 DOI: 10.1172/JCI140046  0.442
2020 Zhang Q, Dou H, Rorsman P. 'Resistance is futile?' - paradoxical inhibitory effects of K channel closure in glucagon-secreting α-cells. The Journal of Physiology. PMID 32716554 DOI: 10.1113/Jp279775  0.537
2020 Kellard JA, Rorsman NJG, Hill TG, Armour SL, van der Bunt M, Rorsman P, Knudsen JG, Briant LJB. Reduced somatostatin signalling leads to hypersecretion of glucagon in mice fed a high fat diet. Molecular Metabolism. 101021. PMID 32446876 DOI: 10.1016/J.Molmet.2020.101021  0.331
2020 Peterson QP, Veres A, Chen L, Slama MQ, Kenty JHR, Hassoun S, Brown MR, Dou H, Duffy CD, Zhou Q, Matveyenko AV, Tyrberg B, Sörhede-Winzell M, Rorsman P, Melton DA. A method for the generation of human stem cell-derived alpha cells. Nature Communications. 11: 2241. PMID 32382023 DOI: 10.1038/S41467-020-16049-3  0.403
2020 Holman RR, Clark A, Rorsman P. β-cell secretory dysfunction: a key cause of type 2 diabetes. The Lancet. Diabetes & Endocrinology. 8: 370. PMID 32333873 DOI: 10.1016/S2213-8587(20)30119-4  0.325
2020 Hodson DJ, Rorsman P. A Variation on the Theme: SGLT2 Inhibition and Glucagon Secretion in Human Islets. Diabetes. 69: 864-866. PMID 32312904 DOI: 10.2337/Dbi19-0035  0.458
2020 Satin LS, Zhang Q, Rorsman P. "Take Me To Your Leader": An Electrophysiological Appraisal of the Role of Hub Cells in Pancreatic Islets. Diabetes. 69: 830-836. PMID 32312899 DOI: 10.2337/Dbi19-0012  0.46
2020 Dybjer E, Engström G, Helmer C, Nägga K, Rorsman P, Nilsson PM. Incretin hormones, insulin, glucagon and advanced glycation end products in relation to cognitive function in older people with and without diabetes, a population-based study. Diabetic Medicine : a Journal of the British Diabetic Association. 37: 1157-1166. PMID 32020688 DOI: 10.1111/Dme.14267  0.314
2020 Vergari E, Denwood G, Salehi A, Zhang Q, Adam J, Alrifaiy A, Wernstedt Asterholm I, Benrick A, Chibalina MV, Eliasson L, Guida C, Hill TG, Hamilton A, Ramracheya R, Reimann F, ... Rorsman P, et al. Somatostatin secretion by Na-dependent Ca-induced Ca release in pancreatic delta-cells. Nature Metabolism. 2: 32-40. PMID 31993555 DOI: 10.1038/s42255-019-0158-0  0.52
2019 Dwivedi OP, Lehtovirta M, Hastoy B, Chandra V, Krentz NAJ, Kleiner S, Jain D, Richard AM, Abaitua F, Beer NL, Grotz A, Prasad RB, Hansson O, Ahlqvist E, Krus U, ... Rorsman P, et al. Loss of ZnT8 function protects against diabetes by enhanced insulin secretion. Nature Genetics. PMID 31676859 DOI: 10.1038/S41588-019-0513-9  0.475
2019 Denwood G, Tarasov A, Salehi A, Vergari E, Ramracheya R, Takahashi H, Nikolaev VO, Seino S, Gribble F, Reimann F, Rorsman P, Zhang Q. Glucose stimulates somatostatin secretion in pancreatic δ-cells by cAMP-dependent intracellular Ca release. The Journal of General Physiology. PMID 31358556 DOI: 10.1085/Jgp.201912351  0.561
2019 Haythorne E, Rohm M, van de Bunt M, Brereton MF, Tarasov AI, Blacker TS, Sachse G, Silva Dos Santos M, Terron Exposito R, Davis S, Baba O, Fischer R, Duchen MR, Rorsman P, MacRae JI, et al. Diabetes causes marked inhibition of mitochondrial metabolism in pancreatic β-cells. Nature Communications. 10: 2474. PMID 31171772 DOI: 10.1038/S41467-019-10189-X  0.429
2019 Guida C, Stephen SD, Watson M, Dempster N, Larraufie P, Marjot T, Cargill T, Rickers L, Pavlides M, Tomlinson J, Cobbold JFL, Zhao CM, Chen D, Gribble F, Reimann F, ... ... Rorsman P, et al. PYY plays a key role in the resolution of diabetes following bariatric surgery in humans. Ebiomedicine. PMID 30639417 DOI: 10.1016/J.Ebiom.2018.12.040  0.33
2019 Vergari E, Knudsen JG, Ramracheya R, Salehi A, Zhang Q, Adam J, Asterholm IW, Benrick A, Briant LJB, Chibalina MV, Gribble FM, Hamilton A, Hastoy B, Reimann F, Rorsman NJG, ... Rorsman P, et al. Insulin inhibits glucagon release by SGLT2-induced stimulation of somatostatin secretion. Nature Communications. 10: 139. PMID 30635569 DOI: 10.1038/S41467-018-08193-8  0.43
2019 Knudsen JG, Rorsman P. β Cell Dysfunction in Type 2 Diabetes: Drained of Energy? Cell Metabolism. 29: 1-2. PMID 30625305 DOI: 10.1016/J.Cmet.2018.12.015  0.402
2019 Rorsman P, Eliasson L, Renström E, Gromada J, Barg S, Göpel S. The Cell Physiology of Biphasic Insulin Secretion. News in Physiological Sciences : An International Journal of Physiology Produced Jointly by the International Union of Physiological Sciences and the American Physiological Society. 15: 72-77. PMID 11390882 DOI: 10.1152/physiologyonline.2000.15.2.72  0.403
2019 MIRANDA CA, DOU H, TOLö J, TARASOV AI, RORSMAN P. 340-LB: Optogenetic Control of a-Cell Electrical Activity and Glucagon Secretion in Intact Islets Diabetes. 68: 340-LB. DOI: 10.2337/Db19-340-Lb  0.563
2019 DOU H, MIRANDA CA, ZHANG Q, RORSMAN P, TOLö J. 339-LB: Modulation of Insulin and Glucagon Secretion by Optogenetic Control of Delta-Cell Electrical Activity in Pancreatic Islets Diabetes. 68: 339-LB. DOI: 10.2337/Db19-339-Lb  0.556
2019 KELLARD J, BRIANT L, KNUDSEN JG, RORSMAN P. 1975-P: Increased Pancreatic a Cell Ca2+ Oscillations Explain Hyperglucagonemia in High-Fat Diet-Fed Mice Diabetes. 68: 1975-P. DOI: 10.2337/Db19-1975-P  0.478
2018 Hastoy B, Godazgar M, Clark A, Nylander V, Spiliotis I, van de Bunt M, Chibalina MV, Barrett A, Burrows C, Tarasov AI, Scharfmann R, Gloyn AL, Rorsman P. Electrophysiological properties of human beta-cell lines EndoC-βH1 and -βH2 conform with human beta-cells. Scientific Reports. 8: 16994. PMID 30451893 DOI: 10.1038/S41598-018-34743-7  0.572
2018 Knudsen JG, Hamilton A, Ramracheya R, Tarasov AI, Brereton M, Haythorne E, Chibalina MV, Spégel P, Mulder H, Zhang Q, Ashcroft FM, Adam J, Rorsman P. Dysregulation of Glucagon Secretion by Hyperglycemia-Induced Sodium-Dependent Reduction of ATP Production. Cell Metabolism. PMID 30415925 DOI: 10.1016/J.Cmet.2018.10.003  0.474
2018 Ramracheya R, Chapman C, Chibalina M, Dou H, Miranda C, González A, Moritoh Y, Shigeto M, Zhang Q, Braun M, Clark A, Johnson PR, Rorsman P, Briant LJB. GLP-1 suppresses glucagon secretion in human pancreatic alpha-cells by inhibition of P/Q-type Ca channels. Physiological Reports. 6: e13852. PMID 30187652 DOI: 10.14814/Phy2.13852  0.555
2018 Rebelato E, Santos LR, Carpinelli AR, Rorsman P, Abdulkader F. Short-term high glucose culture potentiates pancreatic beta cell function. Scientific Reports. 8: 13061. PMID 30166558 DOI: 10.1038/S41598-018-31325-5  0.562
2018 Tarasov AI, Galvanovskis J, Rorsman O, Hamilton A, Vergari E, Johnson PRV, Reimann F, Ashcroft FM, Rorsman P. Monitoring real-time hormone release kinetics via high-content 3-D imaging of compensatory endocytosis. Lab On a Chip. PMID 30083680 DOI: 10.1039/C8Lc00417J  0.319
2018 Thomsen SK, Raimondo A, Hastoy B, Sengupta S, Dai XQ, Bautista A, Censin J, Payne AJ, Umapathysivam MM, Spigelman AF, Barrett A, Groves CJ, Beer NL, Manning Fox JE, McCarthy MI, ... ... Rorsman P, et al. Type 2 diabetes risk alleles in PAM impact insulin release from human pancreatic β-cells. Nature Genetics. PMID 30054598 DOI: 10.1038/s41588-018-0173-1  0.324
2018 Briant LJB, Dodd MS, Chibalina MV, Rorsman NJG, Johnson PRV, Carmeliet P, Rorsman P, Knudsen JG. CPT1a-Dependent Long-Chain Fatty Acid Oxidation Contributes to Maintaining Glucagon Secretion from Pancreatic Islets. Cell Reports. 23: 3300-3311. PMID 29898400 DOI: 10.1016/J.Celrep.2018.05.035  0.453
2018 Rorsman P, Huising MO. The somatostatin-secreting pancreatic δ-cell in health and disease. Nature Reviews. Endocrinology. PMID 29773871 DOI: 10.1038/S41574-018-0020-6  0.55
2018 Hamilton A, Zhang Q, Salehi A, Willems M, Knudsen JG, Ringgaard AK, Chapman CE, Gonzalez-Alvarez A, Surdo NC, Zaccolo M, Basco D, Johnson PRV, Ramracheya R, Rutter GA, Galione A, Rorsman P, et al. Adrenaline Stimulates Glucagon Secretion by Tpc2-Dependent CaMobilization from Acidic Stores in Pancreatic α-Cells. Diabetes. PMID 29563152 DOI: 10.2337/Db17-1102  0.502
2018 Godazgar M, Zhang Q, Chibalina MV, Rorsman P. Biphasic voltage-dependent inactivation of human Na1.3, 1.6 and 1.7 Nachannels expressed in rodent insulin-secreting cells. The Journal of Physiology. PMID 29441586 DOI: 10.1113/Jp275587  0.482
2018 Basco D, Zhang Q, Salehi A, Tarasov A, Dolci W, Herrera P, Spiliotis I, Berney X, Tarussio D, Rorsman P, Thorens B. α-cell glucokinase suppresses glucose-regulated glucagon secretion. Nature Communications. 9: 546. PMID 29416045 DOI: 10.1038/S41467-018-03034-0  0.468
2018 Rorsman P, Ashcroft FM. Pancreatic β-Cell Electrical Activity and Insulin Secretion: Of Mice and Men. Physiological Reviews. 98: 117-214. PMID 29212789 DOI: 10.1152/Physrev.00008.2017  0.567
2018 REAL JI, GARCIA BC, ASTERHOLM IW, RORSMAN P. Adiponectin Increases Glucose-Dependent Electrical Activity and Insulin Secretion in Mouse Pancreatic ß Cells Diabetes. 67: 329-OR. DOI: 10.2337/Db18-329-Or  0.515
2018 DAI X, SOLER JC, BRIANT L, SPIGELMAN AF, HANG Y, RORSMAN P, KIM S, MACDONALD P. Pancreatic Alpha-Cell Function and Identity in Human T2D Diabetes. 67: 315-LB. DOI: 10.2337/Db18-315-Lb  0.488
2018 GARCIA BC, WU Y, NORDBECK EB, MUSOVIC S, OLOFSSON CS, RORSMAN P, ASTERHOLM IW. Pancreatic Adipose Tissue in Diet-Induced Type 2 Diabetes Diabetes. 67: 2431-PUB. DOI: 10.2337/Db18-2431-Pub  0.407
2017 Hastoy B, Clark A, Rorsman P, Lang J. Fusion pore in exocytosis: More than an exit gate? A β-cell perspective. Cell Calcium. 68: 45-61. PMID 29129207 DOI: 10.1016/J.Ceca.2017.10.005  0.399
2017 Briant LJB, Reinbothe TM, Spiliotis I, Miranda C, Rodriguez B, Rorsman P. δ- and β-cells are electrically coupled and regulate α-cell activity via somatostatin. The Journal of Physiology. PMID 28975620 DOI: 10.1113/Jp274581  0.423
2017 Adam J, Ramracheya R, Chibalina MV, Ternette N, Hamilton A, Tarasov AI, Zhang Q, Rebelato E, Rorsman NJG, Martín-Del-Río R, Lewis A, Özkan G, Do HW, Spégel P, Saitoh K, ... Rorsman P, et al. Fumarate Hydratase Deletion in Pancreatic β Cells Leads to Progressive Diabetes. Cell Reports. 20: 3135-3148. PMID 28954230 DOI: 10.1016/J.Celrep.2017.08.093  0.485
2017 Babinsky VN, Hannan FM, Ramracheya RD, Zhang Q, Nesbit MA, Hugill A, Bentley L, Hough TA, Joynson E, Stewart M, Aggarwal A, Prinz-Wohlgenannt M, Gorvin CM, Kallay E, Wells S, ... Rorsman P, et al. Mutant mice with calcium-sensing receptor (CaSR) activation have hyperglycemia, that is rectified by calcilytic therapy. Endocrinology. PMID 28575322 DOI: 10.1210/En.2017-00111  0.492
2017 Gandasi NR, Yin P, Riz M, Chibalina MV, Cortese G, Lund PE, Matveev V, Rorsman P, Sherman A, Pedersen MG, Barg S. Ca2+ channel clustering with insulin-containing granules is disturbed in type 2 diabetes. The Journal of Clinical Investigation. PMID 28481223 DOI: 10.1172/Jci88491  0.585
2017 Philippaert K, Pironet A, Mesuere M, Sones W, Vermeiren L, Kerselaers S, Pinto S, Segal A, Antoine N, Gysemans C, Laureys J, Lemaire K, Gilon P, Cuypers E, Tytgat J, ... Rorsman P, et al. Steviol glycosides enhance pancreatic beta-cell function and taste sensation by potentiation of TRPM5 channel activity. Nature Communications. 8: 14733. PMID 28361903 DOI: 10.1038/Ncomms14733  0.509
2017 Briant LJ, Zhang Q, Vergari E, Kellard JA, Rodriguez B, Ashcroft FM, Rorsman P. Functional identification of islet cell types by electrophysiological fingerprinting. Journal of the Royal Society, Interface. 14. PMID 28275121 DOI: 10.1098/Rsif.2016.0999  0.39
2017 Amisten S, Mohammad Al-Amily I, Soni A, Hawkes R, Atanes P, Persaud SJ, Rorsman P, Salehi A. Anti-diabetic action of all-trans retinoic acid and the orphan G protein coupled receptor GPRC5C in pancreatic β-cells. Endocrine Journal. PMID 28228611 DOI: 10.1507/Endocrj.Ej16-0338  0.517
2017 Shigeto M, Cha CY, Rorsman P, Kaku K. A role of PLC/PKC-dependent pathway in GLP-1-stimulated insulin secretion. Journal of Molecular Medicine (Berlin, Germany). PMID 28097390 DOI: 10.1007/S00109-017-1508-6  0.546
2016 Brereton MF, Rohm M, Shimomura K, Holland C, Tornovsky-Babeay S, Dadon D, Iberl M, Chibalina MV, Lee S, Glaser B, Dor Y, Rorsman P, Clark A, Ashcroft FM. Hyperglycaemia induces metabolic dysfunction and glycogen accumulation in pancreatic β-cells. Nature Communications. 7: 13496. PMID 27882918 DOI: 10.1038/Ncomms13496  0.353
2016 Cross SE, Vaughan RH, Willcox AJ, McBride AJ, Abraham AA, Han B, Johnson JD, Maillard E, Bateman PA, Ramracheya RD, Rorsman P, Kadler KE, Dunne MJ, Hughes SJ, Johnson PR. Key matrix proteins within the pancreatic islet basement membrane are differentially digested during human islet isolation. American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons. PMID 27456745 DOI: 10.1111/Ajt.13975  0.36
2016 Ramracheya RD, McCulloch LJ, Clark A, Wiggins D, Johannessen H, Olsen MK, Cai X, Zhao CM, Chen D, Rorsman P. PYY-Dependent Restoration of Impaired Insulin and Glucagon Secretion in Type 2 Diabetes following Roux-En-Y Gastric Bypass Surgery. Cell Reports. PMID 27117413 DOI: 10.1016/J.Celrep.2016.03.091  0.44
2016 Briant L, Salehi A, Vergari E, Zhang Q, Rorsman P. Glucagon secretion from pancreatic α-cells. Upsala Journal of Medical Sciences. 1-7. PMID 27044683 DOI: 10.3109/03009734.2016.1156789  0.509
2016 Collins SC, Do HW, Hastoy B, Hugill A, Adam J, Chibalina MV, Galvanovskis J, Godazgar M, Lee S, Goldsworthy M, Salehi A, Tarasov AI, Rosengren AH, Cox R, Rorsman P. Increased expression of the diabetes gene SOX4 reduces insulin secretion by impaired fusion pore expansion. Diabetes. PMID 26993066 DOI: 10.2337/Db15-1489  0.522
2016 Tarasov AI, Rorsman P. Dramatis Personae in β-Cell Mass Regulation: Enter SerpinB1. Cell Metabolism. 23: 8-10. PMID 26771113 DOI: 10.1016/J.Cmet.2015.12.011  0.431
2015 Szabat M, Modi H, Ramracheya R, Girbinger V, Chan F, Lee JT, Piske M, Kamal S, Carol Yang YH, Welling A, Rorsman P, Johnson JD. High-content screening identifies a role for Na(+) channels in insulin production. Royal Society Open Science. 2: 150306. PMID 27019722 DOI: 10.1098/Rsos.150306  0.487
2015 Cane MC, Parrington J, Rorsman P, Galione A, Rutter GA. The two pore channel TPC2 is dispensable in pancreatic β-cells for normal Ca(2+) dynamics and insulin secretion. Cell Calcium. PMID 26769314 DOI: 10.1016/J.Ceca.2015.12.004  0.593
2015 Shigeto M, Ramracheya R, Tarasov AI, Cha CY, Chibalina MV, Hastoy B, Philippaert K, Reinbothe T, Rorsman N, Salehi A, Sones WR, Vergari E, Weston C, Gorelik J, Katsura M, ... Rorsman P, et al. GLP-1 stimulates insulin secretion by PKC-dependent TRPM4 and TRPM5 activation. The Journal of Clinical Investigation. PMID 26571400 DOI: 10.1172/Jci81975  0.59
2015 Wu B, Wei S, Petersen N, Ali Y, Wang X, Bacaj T, Rorsman P, Hong W, Südhof TC, Han W. Synaptotagmin-7 phosphorylation mediates GLP-1-dependent potentiation of insulin secretion from β-cells. Proceedings of the National Academy of Sciences of the United States of America. 112: 9996-10001. PMID 26216970 DOI: 10.1073/Pnas.1513004112  0.498
2015 Arredouani A, Ruas M, Collins SC, Parkesh R, Clough F, Pillinger T, Coltart G, Rietdorf K, Royle A, Johnson P, Braun M, Zhang Q, Sones W, Shimomura K, Morgan AJ, ... Rorsman P, et al. NAADP and endolysosomal two-pore channels modulate membrane excitability and stimulus-secretion coupling in mouse pancreatic β cells. The Journal of Biological Chemistry. PMID 26152717 DOI: 10.1074/Jbc.M115.671248  0.559
2015 Szabat M, Modi H, Ramracheya R, Girbinger V, Chan F, Lee JTC, Piske M, Kamal S, Yang YHC, Welling A, Rorsman P, Johnson JD. High-content screening identifies a role for Na+ channels in insulin production Royal Society Open Science. 2. DOI: 10.1098/rsos.150306  0.312
2015 Wu B, Wei S, Petersen N, Ali Y, Wang X, Bacaj T, Rorsman P, Hong W, Südhof TC, Han W. Synaptotagmin-7 phosphorylation mediates GLP-1-dependent potentiation of insulin secretion from β-cells Proceedings of the National Academy of Sciences of the United States of America. 112: 9996-10001. DOI: 10.1073/pnas.1513004112  0.38
2014 Chandra V, Albagli-Curiel O, Hastoy B, Piccand J, Randriamampita C, Vaillant E, Cavé H, Busiah K, Froguel P, Vaxillaire M, Rorsman P, Polak M, Scharfmann R. RFX6 regulates insulin secretion by modulating Ca2+ homeostasis in human β cells. Cell Reports. 9: 2206-18. PMID 25497100 DOI: 10.1016/J.Celrep.2014.11.010  0.547
2014 Gheni G, Ogura M, Iwasaki M, Yokoi N, Minami K, Nakayama Y, Harada K, Hastoy B, Wu X, Takahashi H, Kimura K, Matsubara T, Hoshikawa R, Hatano N, Sugawara K, ... Rorsman P, et al. Glutamate acts as a key signal linking glucose metabolism to incretin/cAMP action to amplify insulin secretion. Cell Reports. 9: 661-73. PMID 25373904 DOI: 10.1016/J.Celrep.2014.09.030  0.517
2014 Zhang Q, Chibalina MV, Bengtsson M, Groschner LN, Ramracheya R, Rorsman NJ, Leiss V, Nassar MA, Welling A, Gribble FM, Reimann F, Hofmann F, Wood JN, Ashcroft FM, Rorsman P. Na+ current properties in islet α- and β-cells reflect cell-specific Scn3a and Scn9a expression. The Journal of Physiology. 592: 4677-96. PMID 25172946 DOI: 10.1113/Jphysiol.2014.274209  0.762
2014 Brereton MF, Iberl M, Shimomura K, Zhang Q, Adriaenssens AE, Proks P, Spiliotis II, Dace W, Mattis KK, Ramracheya R, Gribble FM, Reimann F, Clark A, Rorsman P, Ashcroft FM. Reversible changes in pancreatic islet structure and function produced by elevated blood glucose. Nature Communications. 5: 4639. PMID 25145789 DOI: 10.1038/Ncomms5639  0.428
2014 Rorsman P, Ramracheya R, Rorsman NJ, Zhang Q. ATP-regulated potassium channels and voltage-gated calcium channels in pancreatic alpha and beta cells: similar functions but reciprocal effects on secretion. Diabetologia. 57: 1749-61. PMID 24906950 DOI: 10.1007/S00125-014-3279-8  0.495
2014 Latreille M, Hausser J, Stützer I, Zhang Q, Hastoy B, Gargani S, Kerr-Conte J, Pattou F, Zavolan M, Esguerra JL, Eliasson L, Rülicke T, Rorsman P, Stoffel M. MicroRNA-7a regulates pancreatic β cell function. The Journal of Clinical Investigation. 124: 2722-35. PMID 24789908 DOI: 10.1172/Jci73066  0.369
2013 Soni A, Amisten S, Rorsman P, Salehi A. GPRC5B a putative glutamate-receptor candidate is negative modulator of insulin secretion. Biochemical and Biophysical Research Communications. PMID 24513213 DOI: 10.1016/J.Bbrc.2013.10.099  0.498
2013 Zhang Q, Ramracheya R, Lahmann C, Tarasov A, Bengtsson M, Braha O, Braun M, Brereton M, Collins S, Galvanovskis J, Gonzalez A, Groschner LN, Rorsman NJ, Salehi A, Travers ME, ... Rorsman P, et al. Role of KATP channels in glucose-regulated glucagon secretion and impaired counterregulation in type 2 diabetes. Cell Metabolism. 18: 871-82. PMID 24315372 DOI: 10.1016/J.Cmet.2013.10.014  0.809
2013 Ashcroft FM, Rorsman P. K(ATP) channels and islet hormone secretion: new insights and controversies. Nature Reviews. Endocrinology. 9: 660-9. PMID 24042324 DOI: 10.1038/Nrendo.2013.166  0.503
2013 Amisten S, Salehi A, Rorsman P, Jones PM, Persaud SJ. An atlas and functional analysis of G-protein coupled receptors in human islets of Langerhans. Pharmacology & Therapeutics. 139: 359-91. PMID 23694765 DOI: 10.1016/J.Pharmthera.2013.05.004  0.388
2013 Rorsman P, Braun M. Regulation of insulin secretion in human pancreatic islets. Annual Review of Physiology. 75: 155-79. PMID 22974438 DOI: 10.1146/Annurev-Physiol-030212-183754  0.546
2012 Kailey B, van de Bunt M, Cheley S, Johnson PR, MacDonald PE, Gloyn AL, Rorsman P, Braun M. SSTR2 is the functionally dominant somatostatin receptor in human pancreatic β- and α-cells. American Journal of Physiology. Endocrinology and Metabolism. 303: E1107-16. PMID 22932785 DOI: 10.1152/Ajpendo.00207.2012  0.419
2012 Braun M, Ramracheya R, Rorsman P. Autocrine regulation of insulin secretion. Diabetes, Obesity & Metabolism. 14: 143-51. PMID 22928575 DOI: 10.1111/J.1463-1326.2012.01642.X  0.514
2012 Salehi A, Gunnerud U, Muhammed SJ, Ostman E, Holst JJ, Björck I, Rorsman P. The insulinogenic effect of whey protein is partially mediated by a direct effect of amino acids and GIP on β-cells. Nutrition & Metabolism. 9: 48. PMID 22647249 DOI: 10.1186/1743-7075-9-48  0.467
2012 Rosengren AH, Braun M, Mahdi T, Andersson SA, Travers ME, Shigeto M, Zhang E, Almgren P, Ladenvall C, Axelsson AS, Edlund A, Pedersen MG, Jonsson A, Ramracheya R, Tang Y, ... Rorsman P, et al. Reduced insulin exocytosis in human pancreatic β-cells with gene variants linked to type 2 diabetes. Diabetes. 61: 1726-33. PMID 22492527 DOI: 10.2337/Db11-1516  0.514
2012 Ashcroft FM, Rorsman P. Diabetes mellitus and the β cell: the last ten years. Cell. 148: 1160-71. PMID 22424227 DOI: 10.1016/J.Cell.2012.02.010  0.342
2012 Hoppa MB, Jones E, Karanauskaite J, Ramracheya R, Braun M, Collins SC, Zhang Q, Clark A, Eliasson L, Genoud C, Macdonald PE, Monteith AG, Barg S, Galvanovskis J, Rorsman P. Multivesicular exocytosis in rat pancreatic beta cells. Diabetologia. 55: 1001-12. PMID 22189485 DOI: 10.1007/S00125-011-2400-5  0.806
2012 Rorsman P, Braun M, Zhang Q. Regulation of calcium in pancreatic α- and β-cells in health and disease. Cell Calcium. 51: 300-8. PMID 22177710 DOI: 10.1016/J.Ceca.2011.11.006  0.566
2012 Yashiro H, Tsujihata Y, Takeuchi K, Hazama M, Johnson PR, Rorsman P. The effects of TAK-875, a selective G protein-coupled receptor 40/free fatty acid 1 agonist, on insulin and glucagon secretion in isolated rat and human islets. The Journal of Pharmacology and Experimental Therapeutics. 340: 483-9. PMID 22106100 DOI: 10.1124/Jpet.111.187708  0.497
2011 Hoppa MB, Collins S, Ramracheya R, Hodson L, Amisten S, Zhang Q, Johnson P, Ashcroft FM, Rorsman P. Chronic Palmitate Exposure Inhibits Insulin Secretion by Dissociation of Ca(2+) Channels from Secretory Granules. Cell Metabolism. 13: 487. PMID 28903031 DOI: 10.1016/j.cmet.2011.03.002  0.778
2011 Galvanovskis J, Braun M, Rorsman P. Exocytosis from pancreatic β-cells: mathematical modelling of the exit of low-molecular-weight granule content. Interface Focus. 1: 143-52. PMID 22419980 DOI: 10.1098/Rsfs.2010.0006  0.464
2011 Walker JN, Ramracheya R, Zhang Q, Johnson PR, Braun M, Rorsman P. Regulation of glucagon secretion by glucose: paracrine, intrinsic or both? Diabetes, Obesity & Metabolism. 13: 95-105. PMID 21824262 DOI: 10.1111/J.1463-1326.2011.01450.X  0.555
2011 Rorsman P, Eliasson L, Kanno T, Zhang Q, Gopel S. Electrophysiology of pancreatic β-cells in intact mouse islets of Langerhans. Progress in Biophysics and Molecular Biology. 107: 224-35. PMID 21762719 DOI: 10.1016/J.Pbiomolbio.2011.06.009  0.475
2011 MacDonald PE, Rorsman P. Per-arnt-sim (PAS) domain kinase (PASK) as a regulator of glucagon secretion. Diabetologia. 54: 719-21. PMID 21327866 DOI: 10.1007/S00125-011-2072-1  0.434
2011 Walker JN, Johnson PR, Shigeto M, Hughes SJ, Clark A, Rorsman P. Glucose-responsive beta cells in islets isolated from a patient with long-standing type 1 diabetes mellitus. Diabetologia. 54: 200-2. PMID 20963398 DOI: 10.1007/S00125-010-1930-6  0.463
2011 Hoppa MB, Collins S, Ramracheya R, Hodson L, Amisten S, Zhang Q, Johnson P, Ashcroft FM, Rorsman P. Chronic palmitate exposure inhibits insulin secretion by dissociation of Ca2+ channels from secretory granules (Cell Metabolism) Cell Metabolism. 13: 487. DOI: 10.1016/j.cmet.2011.03.002  0.785
2011 Zhang Q, Ramracheya R, Braha O, Rorsman P. Glucose Inhibits Glucagon Secretion from Pancreatic Alpha-Cells by Closure of KATP-Channels Biophysical Journal. 100: 571a-572a. DOI: 10.1016/J.Bpj.2010.12.3310  0.523
2010 Akhmedov D, Braun M, Mataki C, Park KS, Pozzan T, Schoonjans K, Rorsman P, Wollheim CB, Wiederkehr A. Mitochondrial matrix pH controls oxidative phosphorylation and metabolism-secretion coupling in INS-1E clonal beta cells. Faseb Journal : Official Publication of the Federation of American Societies For Experimental Biology. 24: 4613-26. PMID 20647546 DOI: 10.1096/fj.10-162222  0.305
2010 Clark RH, McTaggart JS, Webster R, Mannikko R, Iberl M, Sim XL, Rorsman P, Glitsch M, Beeson D, Ashcroft FM. Muscle dysfunction caused by a KATP channel mutation in neonatal diabetes is neuronal in origin. Science (New York, N.Y.). 329: 458-61. PMID 20595581 DOI: 10.1126/Science.1186146  0.347
2010 Braun M, Rorsman P. The glucagon-producing alpha cell: an electrophysiologically exceptional cell. Diabetologia. 53: 1827-30. PMID 20556353 DOI: 10.1007/S00125-010-1823-8  0.428
2010 Ramracheya R, Ward C, Shigeto M, Walker JN, Amisten S, Zhang Q, Johnson PR, Rorsman P, Braun M. Membrane potential-dependent inactivation of voltage-gated ion channels in alpha-cells inhibits glucagon secretion from human islets. Diabetes. 59: 2198-208. PMID 20547976 DOI: 10.2337/Db09-1505  0.401
2010 De Marinis YZ, Salehi A, Ward CE, Zhang Q, Abdulkader F, Bengtsson M, Braha O, Braun M, Ramracheya R, Amisten S, Habib AM, Moritoh Y, Zhang E, Reimann F, Rosengren AH, ... Rorsman P, et al. GLP-1 inhibits and adrenaline stimulates glucagon release by differential modulation of N- and L-type Ca2+ channel-dependent exocytosis. Cell Metabolism. 11: 543-53. PMID 20519125 DOI: 10.1016/J.Cmet.2010.04.007  0.546
2010 Collins SC, Hoppa MB, Walker JN, Amisten S, Abdulkader F, Bengtsson M, Fearnside J, Ramracheya R, Toye AA, Zhang Q, Clark A, Gauguier D, Rorsman P. Progression of diet-induced diabetes in C57BL6J mice involves functional dissociation of Ca2(+) channels from secretory vesicles. Diabetes. 59: 1192-201. PMID 20150285 DOI: 10.2337/Db09-0791  0.816
2010 Obermüller S, Calegari F, King A, Lindqvist A, Lundquist I, Salehi A, Francolini M, Rosa P, Rorsman P, Huttner WB, Barg S. Defective secretion of islet hormones in chromogranin-B deficient mice. Plos One. 5: e8936. PMID 20126668 DOI: 10.1371/Journal.Pone.0008936  0.536
2010 De Marinis YZ, Zhang E, Amisten S, Taneera J, Renström E, Rorsman P, Eliasson L. Enhancement of glucagon secretion in mouse and human pancreatic alpha cells by protein kinase C (PKC) involves intracellular trafficking of PKCalpha and PKCdelta. Diabetologia. 53: 717-29. PMID 20020096 DOI: 10.1007/S00125-009-1635-X  0.371
2010 Rosengren AH, Jokubka R, Tojjar D, Granhall C, Hansson O, Li DQ, Nagaraj V, Reinbothe TM, Tuncel J, Eliasson L, Groop L, Rorsman P, Salehi A, Lyssenko V, Luthman H, et al. Overexpression of alpha2A-adrenergic receptors contributes to type 2 diabetes. Science (New York, N.Y.). 327: 217-20. PMID 19965390 DOI: 10.1126/Science.1176827  0.44
2010 Hoppa MB, Galvanovskis J, Braun M, Karanauskaite J, Rorsman P. Compound Exocytosis in Rat Beta-Cells Triggered by Global Elevation of Cytosolic Calcium Biophysical Journal. 98: 438a. DOI: 10.1016/J.Bpj.2009.12.2380  0.799
2009 Santesson S, Degerman E, Rorsman P, Johansson T, Lemos S, Nilsson S. Cell-cell communication between adipocytes and pancreatic beta-cells in acoustically levitated droplets. Integrative Biology : Quantitative Biosciences From Nano to Macro. 1: 595-601. PMID 20023776 DOI: 10.1039/B907834G  0.514
2009 Hoppa MB, Collins S, Ramracheya R, Hodson L, Amisten S, Zhang Q, Johnson P, Ashcroft FM, Rorsman P. Chronic palmitate exposure inhibits insulin secretion by dissociation of Ca(2+) channels from secretory granules. Cell Metabolism. 10: 455-65. PMID 19945403 DOI: 10.1016/J.Cmet.2009.09.011  0.81
2009 Li DQ, Jing X, Salehi A, Collins SC, Hoppa MB, Rosengren AH, Zhang E, Lundquist I, Olofsson CS, Mörgelin M, Eliasson L, Rorsman P, Renström E. Suppression of sulfonylurea- and glucose-induced insulin secretion in vitro and in vivo in mice lacking the chloride transport protein ClC-3. Cell Metabolism. 10: 309-15. PMID 19808023 DOI: 10.1016/J.Cmet.2009.08.011  0.798
2009 Gilon P, Rorsman P. NALCN: a regulated leak channel. Embo Reports. 10: 963-4. PMID 19662077 DOI: 10.1038/Embor.2009.185  0.343
2009 Braun M, Ramracheya R, Amisten S, Bengtsson M, Moritoh Y, Zhang Q, Johnson PR, Rorsman P. Somatostatin release, electrical activity, membrane currents and exocytosis in human pancreatic delta cells. Diabetologia. 52: 1566-78. PMID 19440689 DOI: 10.1007/S00125-009-1382-Z  0.429
2009 Gromada J, Duttaroy A, Rorsman P. The insulin receptor talks to glucagon? Cell Metabolism. 9: 303-5. PMID 19356709 DOI: 10.1016/J.Cmet.2009.03.008  0.445
2009 Gloyn AL, Braun M, Rorsman P. Type 2 diabetes susceptibility gene TCF7L2 and its role in beta-cell function. Diabetes. 58: 800-2. PMID 19336690 DOI: 10.2337/Db09-0099  0.353
2009 Poy MN, Hausser J, Trajkovski M, Braun M, Collins S, Rorsman P, Zavolan M, Stoffel M. miR-375 maintains normal pancreatic alpha- and beta-cell mass. Proceedings of the National Academy of Sciences of the United States of America. 106: 5813-8. PMID 19289822 DOI: 10.1073/Pnas.0810550106  0.403
2009 Olofsson CS, HÃ¥kansson J, Salehi A, Bengtsson M, Galvanovskis J, Partridge C, SörhedeWinzell M, Xian X, Eliasson L, Lundquist I, Semb H, Rorsman P. Impaired insulin exocytosis in neural cell adhesion molecule-/- mice due to defective reorganization of the submembrane F-actin network. Endocrinology. 150: 3067-75. PMID 19213846 DOI: 10.1210/En.2008-0475  0.563
2009 Gustavsson N, Wei SH, Hoang DN, Lao Y, Zhang Q, Radda GK, Rorsman P, Südhof TC, Han W. Synaptotagmin-7 is a principal Ca2+ sensor for Ca2+ -induced glucagon exocytosis in pancreas. The Journal of Physiology. 587: 1169-78. PMID 19171650 DOI: 10.1113/Jphysiol.2008.168005  0.547
2009 Braun M, Ramracheya R, Johnson PR, Rorsman P. Exocytotic properties of human pancreatic beta-cells. Annals of the New York Academy of Sciences. 1152: 187-93. PMID 19161389 DOI: 10.1111/J.1749-6632.2008.03992.X  0.583
2009 Sumara G, Formentini I, Collins S, Sumara I, Windak R, Bodenmiller B, Ramracheya R, Caille D, Jiang H, Platt KA, Meda P, Aebersold R, Rorsman P, Ricci R. Regulation of PKD by the MAPK p38delta in insulin secretion and glucose homeostasis. Cell. 136: 235-48. PMID 19135240 DOI: 10.1016/J.Cell.2008.11.018  0.531
2009 Girard CA, Wunderlich FT, Shimomura K, Collins S, Kaizik S, Proks P, Abdulkader F, Clark A, Ball V, Zubcevic L, Bentley L, Clark R, Church C, Hugill A, Galvanovskis J, ... Rorsman P, et al. Expression of an activating mutation in the gene encoding the KATP channel subunit Kir6.2 in mouse pancreatic beta cells recapitulates neonatal diabetes. The Journal of Clinical Investigation. 119: 80-90. PMID 19065048 DOI: 10.1172/Jci35772  0.508
2009 Karanauskaite J, Hoppa MB, Braun M, Galvanovskis J, Rorsman P. Quantal ATP release in rat beta-cells by exocytosis of insulin-containing LDCVs. Pflã¼Gers Archiv : European Journal of Physiology. 458: 389-401. PMID 19018564 DOI: 10.1007/S00424-008-0610-6  0.788
2009 Mårtensson UE, Salehi SA, Windahl S, Gomez MF, Swärd K, Daszkiewicz-Nilsson J, Wendt A, Andersson N, Hellstrand P, Grände PO, Owman C, Rosen CJ, Adamo ML, Lundquist I, Rorsman P, et al. Deletion of the G protein-coupled receptor 30 impairs glucose tolerance, reduces bone growth, increases blood pressure, and eliminates estradiol-stimulated insulin release in female mice. Endocrinology. 150: 687-98. PMID 18845638 DOI: 10.1210/En.2008-0623  0.428
2009 Hanna ST, Pigeau GM, Galvanovskis J, Clark A, Rorsman P, MacDonald PE. Kiss-and-run exocytosis and fusion pores of secretory vesicles in human beta-cells. Pflã¼Gers Archiv : European Journal of Physiology. 457: 1343-50. PMID 18795319 DOI: 10.1007/S00424-008-0588-0  0.449
2009 Hoppa MB, Collins S, Ramracheya R, Johnson P, Ashcroft FM, Rorsman P. Chronic Palmitate Exposure Inhibits Insulin Secretion By Dissociation of Ca2+-Channels From Secretory Vesicles Biophysical Journal. 96: 103a. DOI: 10.1016/J.Bpj.2008.12.442  0.812
2008 Zehetner J, Danzer C, Collins S, Eckhardt K, Gerber PA, Ballschmieter P, Galvanovskis J, Shimomura K, Ashcroft FM, Thorens B, Rorsman P, Krek W. PVHL is a regulator of glucose metabolism and insulin secretion in pancreatic beta cells. Genes & Development. 22: 3135-46. PMID 19056893 DOI: 10.1101/Gad.496908  0.532
2008 Rorsman P, Salehi SA, Abdulkader F, Braun M, MacDonald PE. K(ATP)-channels and glucose-regulated glucagon secretion. Trends in Endocrinology and Metabolism: Tem. 19: 277-84. PMID 18771934 DOI: 10.1016/J.Tem.2008.07.003  0.517
2008 Zhang Q, Galvanovskis J, Abdulkader F, Partridge CJ, Göpel SO, Eliasson L, Rorsman P. Cell coupling in mouse pancreatic beta-cells measured in intact islets of Langerhans. Philosophical Transactions. Series a, Mathematical, Physical, and Engineering Sciences. 366: 3503-23. PMID 18632454 DOI: 10.1098/rsta.2008.0110  0.36
2008 Collins SC, Salehi A, Eliasson L, Olofsson CS, Rorsman P. Long-term exposure of mouse pancreatic islets to oleate or palmitate results in reduced glucose-induced somatostatin and oversecretion of glucagon. Diabetologia. 51: 1689-93. PMID 18622593 DOI: 10.1007/S00125-008-1082-0  0.464
2008 Eliasson L, Abdulkader F, Braun M, Galvanovskis J, Hoppa MB, Rorsman P. Novel aspects of the molecular mechanisms controlling insulin secretion. The Journal of Physiology. 586: 3313-24. PMID 18511483 DOI: 10.1113/Jphysiol.2008.155317  0.806
2008 Braun M, Ramracheya R, Bengtsson M, Zhang Q, Karanauskaite J, Partridge C, Johnson PR, Rorsman P. Voltage-gated ion channels in human pancreatic beta-cells: electrophysiological characterization and role in insulin secretion. Diabetes. 57: 1618-28. PMID 18390794 DOI: 10.2337/Db07-0991  0.521
2008 Speidel D, Salehi A, Obermueller S, Lundquist I, Brose N, Renström E, Rorsman P. CAPS1 and CAPS2 regulate stability and recruitment of insulin granules in mouse pancreatic beta cells. Cell Metabolism. 7: 57-67. PMID 18177725 DOI: 10.1016/J.Cmet.2007.11.009  0.583
2008 Renström E, Rorsman P. Regulation of insulin granule exocytosis Pancreatic Beta Cell in Health and Disease. 147-176. DOI: 10.1007/978-4-431-75452-7_9  0.361
2008 Galvanovskis J, Rorsman P, Söderberg B. Probability of Exocytosis in Pancreatic β-Cells: Dependence on Ca2+ Sensing Latency Times, Ca2+ Channel Kinetic Parameters, and Channel Clustering Biosimulation in Drug Development. 299-311. DOI: 10.1002/9783527622672.ch11  0.336
2007 Nielsen LB, Ploug KB, Swift P, Ørskov C, Jansen-Olesen I, Chiarelli F, Holst JJ, Hougaard P, Pörksen S, Holl R, de Beaufort C, Gammeltoft S, Rorsman P, Mortensen HB, Hansen L, et al. Co-localisation of the Kir6.2/SUR1 channel complex with glucagon-like peptide-1 and glucose-dependent insulinotrophic polypeptide expression in human ileal cells and implications for glycaemic control in new onset type 1 diabetes. European Journal of Endocrinology / European Federation of Endocrine Societies. 156: 663-71. PMID 17535866 DOI: 10.1530/Eje-06-0756  0.502
2007 MacDonald PE, De Marinis YZ, Ramracheya R, Salehi A, Ma X, Johnson PR, Cox R, Eliasson L, Rorsman P. A K ATP channel-dependent pathway within alpha cells regulates glucagon release from both rodent and human islets of Langerhans. Plos Biology. 5: e143. PMID 17503968 DOI: 10.1371/Journal.Pbio.0050143  0.584
2007 Olofsson CS, Collins S, Bengtsson M, Eliasson L, Salehi A, Shimomura K, Tarasov A, Holm C, Ashcroft F, Rorsman P. Long-term exposure to glucose and lipids inhibits glucose-induced insulin secretion downstream of granule fusion with plasma membrane. Diabetes. 56: 1888-97. PMID 17456851 DOI: 10.2337/Db06-1150  0.532
2007 MacDonald PE, Rorsman P. The ins and outs of secretion from pancreatic beta-cells: control of single-vesicle exo- and endocytosis. Physiology (Bethesda, Md.). 22: 113-21. PMID 17420302 DOI: 10.1152/Physiol.00047.2006  0.48
2007 Zhang Q, Bengtsson M, Partridge C, Salehi A, Braun M, Cox R, Eliasson L, Johnson PR, Renström E, Schneider T, Berggren PO, Göpel S, Ashcroft FM, Rorsman P. R-type Ca(2+)-channel-evoked CICR regulates glucose-induced somatostatin secretion. Nature Cell Biology. 9: 453-60. PMID 17369816 DOI: 10.1038/Ncb1563  0.594
2007 Braun M, Wendt A, Karanauskaite J, Galvanovskis J, Clark A, MacDonald PE, Rorsman P. Corelease and differential exit via the fusion pore of GABA, serotonin, and ATP from LDCV in rat pancreatic beta cells. The Journal of General Physiology. 129: 221-31. PMID 17296927 DOI: 10.1085/Jgp.200609658  0.4
2007 Jeans AF, Oliver PL, Johnson R, Capogna M, Vikman J, Molnár Z, Babbs A, Partridge CJ, Salehi A, Bengtsson M, Eliasson L, Rorsman P, Davies KE. A dominant mutation in Snap25 causes impaired vesicle trafficking, sensorimotor gating, and ataxia in the blind-drunk mouse. Proceedings of the National Academy of Sciences of the United States of America. 104: 2431-6. PMID 17283335 DOI: 10.1073/Pnas.0610222104  0.318
2007 Salehi A, Eliasson L, Ma X, Rorsman P, HÃ¥kanson R, Lundquist I. Secretory and electrophysiological characteristics of insulin cells from gastrectomized mice: evidence for the existence of insulinotropic agents in the stomach. Regulatory Peptides. 139: 31-8. PMID 17109976 DOI: 10.1016/J.Regpep.2006.10.001  0.528
2006 MacDonald PE, Braun M, Galvanovskis J, Rorsman P. Release of small transmitters through kiss-and-run fusion pores in rat pancreatic beta cells. Cell Metabolism. 4: 283-90. PMID 17011501 DOI: 10.1016/J.Cmet.2006.08.011  0.447
2006 Vikman J, Ma X, Hockerman GH, Rorsman P, Eliasson L. Antibody inhibition of synaptosomal protein of 25 kDa (SNAP-25) and syntaxin 1 reduces rapid exocytosis in insulin-secreting cells. Journal of Molecular Endocrinology. 36: 503-15. PMID 16720719 DOI: 10.1677/Jme.1.01978  0.476
2006 MacDonald PE, Rorsman P. Oscillations, intercellular coupling, and insulin secretion in pancreatic beta cells. Plos Biology. 4: e49. PMID 16464129 DOI: 10.1371/Journal.Pbio.0040049  0.535
2006 Taneera J, Rosengren A, Renstrom E, Nygren JM, Serup P, Rorsman P, Jacobsen SE. Failure of transplanted bone marrow cells to adopt a pancreatic beta-cell fate. Diabetes. 55: 290-6. PMID 16443759 DOI: 10.2337/Diabetes.55.02.06.Db05-1212  0.368
2005 MacDonald PE, Joseph JW, Rorsman P. Glucose-sensing mechanisms in pancreatic beta-cells. Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences. 360: 2211-25. PMID 16321791 DOI: 10.1098/Rstb.2005.1762  0.516
2005 MacDonald PE, Eliasson L, Rorsman P. Calcium increases endocytotic vesicle size and accelerates membrane fission in insulin-secreting INS-1 cells. Journal of Cell Science. 118: 5911-20. PMID 16317049 DOI: 10.1242/Jcs.02685  0.527
2005 Bengtsson M, StÃ¥hlberg A, Rorsman P, Kubista M. Gene expression profiling in single cells from the pancreatic islets of Langerhans reveals lognormal distribution of mRNA levels. Genome Research. 15: 1388-92. PMID 16204192 DOI: 10.1101/Gr.3820805  0.307
2005 Obermüller S, Lindqvist A, Karanauskaite J, Galvanovskis J, Rorsman P, Barg S. Selective nucleotide-release from dense-core granules in insulin-secreting cells. Journal of Cell Science. 118: 4271-82. PMID 16141231 DOI: 10.1242/Jcs.02549  0.41
2005 MacDonald PE, Obermüller S, Vikman J, Galvanovskis J, Rorsman P, Eliasson L. Regulated exocytosis and kiss-and-run of synaptic-like microvesicles in INS-1 and primary rat beta-cells. Diabetes. 54: 736-43. PMID 15734850 DOI: 10.2337/Diabetes.54.3.736  0.501
2005 Jing X, Li DQ, Olofsson CS, Salehi A, Surve VV, Caballero J, Ivarsson R, Lundquist I, Pereverzev A, Schneider T, Rorsman P, Renström E. CaV2.3 calcium channels control second-phase insulin release. The Journal of Clinical Investigation. 115: 146-54. PMID 15630454 DOI: 10.1172/Jci200522518  0.57
2005 Ma X, Zhang Y, Gromada J, Sewing S, Berggren PO, Buschard K, Salehi A, Vikman J, Rorsman P, Eliasson L. Glucagon stimulates exocytosis in mouse and rat pancreatic alpha-cells by binding to glucagon receptors. Molecular Endocrinology (Baltimore, Md.). 19: 198-212. PMID 15459251 DOI: 10.1210/Me.2004-0059  0.433
2005 Rorsman P. Insulin secretion: Function and therapy of pancreatic beta-cells in diabetes British Journal of Diabetes and Vascular Disease. 5: 187-191.  0.369
2004 Gromada J, Rorsman P. New insights into the regulation of glucagon secretion by glucagon-like peptide-1. Hormone and Metabolic Research = Hormon- Und Stoffwechselforschung = Hormones Et Mã©Tabolisme. 36: 822-9. PMID 15655714 DOI: 10.1055/S-2004-826169  0.421
2004 Barg S, Rorsman P. Insulin secretion: a high-affinity Ca2+ sensor after all? The Journal of General Physiology. 124: 623-5. PMID 15572341 DOI: 10.1085/Jgp.200409206  0.493
2004 Gromada J, Brock B, Schmitz O, Rorsman P. Glucagon-like peptide-1: regulation of insulin secretion and therapeutic potential. Basic & Clinical Pharmacology & Toxicology. 95: 252-62. PMID 15569269 DOI: 10.1111/J.1742-7843.2004.T01-1-Pto950502.X  0.542
2004 Gromada J, Ma X, Høy M, Bokvist K, Salehi A, Berggren PO, Rorsman P. ATP-sensitive K+ channel-dependent regulation of glucagon release and electrical activity by glucose in wild-type and SUR1-/- mouse alpha-cells. Diabetes. 53: S181-9. PMID 15561909 DOI: 10.2337/Diabetes.53.Suppl_3.S181  0.552
2004 Poy MN, Eliasson L, Krutzfeldt J, Kuwajima S, Ma X, Macdonald PE, Pfeffer S, Tuschl T, Rajewsky N, Rorsman P, Stoffel M. A pancreatic islet-specific microRNA regulates insulin secretion. Nature. 432: 226-30. PMID 15538371 DOI: 10.1038/Nature03076  0.391
2004 Olofsson CS, Salehi A, Göpel SO, Holm C, Rorsman P. Palmitate stimulation of glucagon secretion in mouse pancreatic alpha-cells results from activation of L-type calcium channels and elevation of cytoplasmic calcium. Diabetes. 53: 2836-43. PMID 15504963 DOI: 10.2337/Diabetes.53.11.2836  0.527
2004 Braun M, Wendt A, Buschard K, Salehi A, Sewing S, Gromada J, Rorsman P. GABAB receptor activation inhibits exocytosis in rat pancreatic beta-cells by G-protein-dependent activation of calcineurin. The Journal of Physiology. 559: 397-409. PMID 15235087 DOI: 10.1113/Jphysiol.2004.066563  0.584
2004 Kanno T, Ma X, Barg S, Eliasson L, Galvanovskis J, Göpel S, Larsson M, Renström E, Rorsman P. Large dense-core vesicle exocytosis in pancreatic beta-cells monitored by capacitance measurements. Methods (San Diego, Calif.). 33: 302-11. PMID 15183179 DOI: 10.1016/J.Ymeth.2004.01.003  0.471
2004 Sinnegger-Brauns MJ, Hetzenauer A, Huber IG, Renström E, Wietzorrek G, Berjukov S, Cavalli M, Walter D, Koschak A, Waldschütz R, Hering S, Bova S, Rorsman P, Pongs O, Singewald N, et al. Isoform-specific regulation of mood behavior and pancreatic beta cell and cardiovascular function by L-type Ca 2+ channels. The Journal of Clinical Investigation. 113: 1430-9. PMID 15146240 DOI: 10.1172/Jci20208  0.474
2004 Fex M, Olofsson CS, Fransson U, Bacos K, Lindvall H, Sörhede-Winzell M, Rorsman P, Holm C, Mulder H. Hormone-sensitive lipase deficiency in mouse islets abolishes neutral cholesterol ester hydrolase activity but leaves lipolysis, acylglycerides, fat oxidation, and insulin secretion intact. Endocrinology. 145: 3746-53. PMID 15142983 DOI: 10.1210/En.2003-1673  0.542
2004 Olofsson CS, Salehi A, Holm C, Rorsman P. Palmitate increases L-type Ca2+ currents and the size of the readily releasable granule pool in mouse pancreatic beta-cells. The Journal of Physiology. 557: 935-48. PMID 15090611 DOI: 10.1113/Jphysiol.2004.066258  0.594
2004 Wendt A, Birnir B, Buschard K, Gromada J, Salehi A, Sewing S, Rorsman P, Braun M. Glucose inhibition of glucagon secretion from rat alpha-cells is mediated by GABA released from neighboring beta-cells. Diabetes. 53: 1038-45. PMID 15047619 DOI: 10.2337/Diabetes.53.4.1038  0.457
2004 Ashcroft FM, Rorsman P. Molecular defects in insulin secretion in type-2 diabetes. Reviews in Endocrine & Metabolic Disorders. 5: 135-42. PMID 15041789 DOI: 10.1023/B:Remd.0000021435.87776.A7  0.414
2004 Göpel S, Zhang Q, Eliasson L, Ma XS, Galvanovskis J, Kanno T, Salehi A, Rorsman P. Capacitance measurements of exocytosis in mouse pancreatic alpha-, beta- and delta-cells within intact islets of Langerhans. The Journal of Physiology. 556: 711-26. PMID 14966302 DOI: 10.1113/Jphysiol.2003.059675  0.567
2004 Braun M, Wendt A, Birnir B, Broman J, Eliasson L, Galvanovskis J, Gromada J, Mulder H, Rorsman P. Regulated exocytosis of GABA-containing synaptic-like microvesicles in pancreatic beta-cells. The Journal of General Physiology. 123: 191-204. PMID 14769845 DOI: 10.1085/Jgp.200308966  0.413
2004 Ashcroft F, Rorsman P. Type 2 diabetes mellitus: not quite exciting enough? Human Molecular Genetics. 13: R21-31. PMID 14734629 DOI: 10.1093/Hmg/Ddh066  0.377
2003 Schulla V, Renström E, Feil R, Feil S, Franklin I, Gjinovci A, Jing XJ, Laux D, Lundquist I, Magnuson MA, Obermüller S, Olofsson CS, Salehi A, Wendt A, Klugbauer N, ... Rorsman P, et al. Impaired insulin secretion and glucose tolerance in beta cell-selective Ca(v)1.2 Ca2+ channel null mice. The Embo Journal. 22: 3844-54. PMID 12881419 DOI: 10.1093/Emboj/Cdg389  0.578
2003 Rorsman P, Renström E. Insulin granule dynamics in pancreatic beta cells Diabetologia. 46: 1029-1045. PMID 12879249 DOI: 10.1007/S00125-003-1153-1  0.539
2003 Olsen HL, Hoy M, Zhang W, Bertorello AM, Bokvist K, Capito K, Efanov AM, Meister B, Thams P, Yang SN, Rorsman P, Berggren PO, Gromada J. Phosphatidylinositol 4-kinase serves as a metabolic sensor and regulates priming of secretory granules in pancreatic beta cells. Proceedings of the National Academy of Sciences of the United States of America. 100: 5187-92. PMID 12700357 DOI: 10.1073/Pnas.0931282100  0.533
2003 Høy M, Olsen HL, Andersen HS, Bokvist K, Buschard K, Hansen J, Jacobsen P, Petersen JS, Rorsman P, Gromada J. Imidazoline NNC77-0074 stimulates insulin secretion and inhibits glucagon release by control of Ca2+-dependent exocytosis in pancreatic α- and β-cells European Journal of Pharmacology. 466: 213-221. PMID 12679159 DOI: 10.1016/S0014-2999(03)01537-1  0.596
2003 Eliasson L, Ma X, Renström E, Barg S, Berggren PO, Galvanovskis J, Gromada J, Jing X, Lundquist I, Salehi A, Sewing S, Rorsman P. SUR1 regulates PKA-independent cAMP-induced granule priming in mouse pancreatic B-cells. The Journal of General Physiology. 121: 181-97. PMID 12601083 DOI: 10.1085/Jgp.20028707  0.486
2002 Kanno T, Rorsman P, Göpel SO. Glucose-dependent regulation of rhythmic action potential firing in pancreatic β-cells by KATP-channel modulation Journal of Physiology. 545: 501-507. PMID 12456829 DOI: 10.1113/Jphysiol.2002.031344  0.517
2002 Gromada J, Bokvist K, Høy M, Olsen HL, Lindström P, Hansen BS, Gotfredsen CF, Rorsman P, Thomsen MK. Nateglinide, but not repaglinide, stimulates growth hormone release in rat pituitary cells by inhibition of K channels and stimulation of cyclic AMP-dependent exocytosis. European Journal of Endocrinology / European Federation of Endocrine Societies. 147: 133-42. PMID 12088930 DOI: 10.1530/Eje.0.1470133  0.482
2002 Olofsson CS, Göpel SO, Barg S, Galvanovskis J, Ma X, Salehi A, Rorsman P, Eliasson L. Fast insulin secretion reflects exocytosis of docked granules in mouse pancreatic B-cells. Pflã¼Gers Archiv : European Journal of Physiology. 444: 43-51. PMID 11976915 DOI: 10.1007/S00424-002-0781-5  0.611
2002 Kanno T, Göpel SO, Rorsman P, Wakui M. Cellular function in multicellular system for hormone-secretion: Electrophysiological aspect of studies on α-, β- and δ-cells of the pancreatic islet Neuroscience Research. 42: 79-90. PMID 11849727 DOI: 10.1016/S0168-0102(01)00318-2  0.538
2002 Barg S, Eliasson L, Renström E, Rorsman P. A subset of 50 secretory granules in close contact with L-type Ca2+ channels accounts for first-phase insulin secretion in mouse β-cells Diabetes. 51: S74-S82. PMID 11815462 DOI: 10.2337/Diabetes.51.2007.S74  0.587
2002 Renström E, Barg S, Thévenod F, Rorsman P. Sulfonylurea-mediated stimulation of insulin exocytosis via an ATP-sensitive K+ channel-independent action Diabetes. 51: S33-S36. PMID 11815455 DOI: 10.2337/Diabetes.51.2007.S33  0.558
2002 Barg S, Olofsson CS, Schriever-Abeln J, Wendt A, Gebre-Medhin S, Renström E, Rorsman P. Delay between fusion pore opening and peptide release from large dense-core vesicles in neuroendocrine cells Neuron. 33: 287-299. PMID 11804575 DOI: 10.1016/S0896-6273(02)00563-9  0.336
2001 Barg S, Ma X, Eliasson L, Galvanovskis J, Göpel SO, Obermüller S, Platzer J, Renström E, Trus M, Atlas D, Striessnig J, Rorsman P. Fast exocytosis with few Ca(2+) channels in insulin-secreting mouse pancreatic B cells. Biophysical Journal. 81: 3308-23. PMID 11720994 DOI: 10.1016/S0006-3495(01)75964-4  0.49
2001 Gromada J, Høy M, Buschard K, Salehi A, Rorsman P. Somatostatin inhibits exocytosis in rat pancreatic alpha-cells by G(i2)-dependent activation of calcineurin and depriming of secretory granules. The Journal of Physiology. 535: 519-32. PMID 11533141 DOI: 10.1111/J.1469-7793.2001.00519.X  0.487
2001 Barg S, Huang P, Eliasson L, Nelson DJ, Obermüller S, Rorsman P, Thévenod F, Renström E. Priming of insulin granules for exocytosis by granular Cl(-) uptake and acidification. Journal of Cell Science. 114: 2145-54. PMID 11493650  0.47
2001 Gromada J, Høy M, Olsen HL, Gotfredsen CF, Buschard K, Rorsman P, Bokvist K. Gi2 proteins couple somatostatin receptors to low-conductance K+ channels in rat pancreatic α-cells Pflugers Archiv European Journal of Physiology. 442: 19-26. PMID 11374064 DOI: 10.1007/S004240000474  0.408
2001 Larsson-Nyrén G, Sehlin J, Rorsman P, Renström E. Perchlorate stimulates insulin secretion by shifting the gating of L-type Ca2+ currents in mouse pancreatic B-cells towards negative potentials Pflugers Archiv European Journal of Physiology. 441: 587-595. PMID 11294239 DOI: 10.1007/S004240000426  0.558
2000 Göpel SO, Kanno T, Barg S, Weng XG, Gromada J, Rorsman P. Regulation of glucagon release in mouse α-cells by K(ATP) channels and inactivation of TTX-sensitive Na+ channels Journal of Physiology. 528: 509-520. PMID 11060128 DOI: 10.1111/J.1469-7793.2000.00509.X  0.546
2000 Gopel SO, Kanno T, Barg S, Rorsman P. Patch-clamp characterisation of somatostatin-secreting δ-cells in intact mouse pancreatic islets Journal of Physiology. 528: 497-507. PMID 11060127 DOI: 10.1111/J.1469-7793.2000.00497.X  0.511
2000 Barg S, Galvanovskis J, Gopel SO, Rorsman P, Eliasson L. Tight coupling between electrical activity and exocytosis in mouse glucagon-secreting α-cells Diabetes. 49: 1500-1510. PMID 10969834 DOI: 10.2337/Diabetes.49.9.1500  0.483
2000 Høy M, Olsen HL, Bokvist K, Buschard K, Barg S, Rorsman P, Gromada J. Tolbutamide stimulates exocytosis of glucagon by inhibition of a mitochondrial-like ATP-sensitive K+ (K(ATP)) conductance in rat pancreatic A-cells Journal of Physiology. 527: 109-120. PMID 10944174 DOI: 10.1111/J.1469-7793.2000.00109.X  0.47
2000 Bokvist K, Holmqvist M, Gromada J, Rorsman P. Compound exocytosis in voltage-clamped mouse pancreatic β-cells revealed by carbon fibre amperometry Pflugers Archiv European Journal of Physiology. 439: 634-645. PMID 10764224 DOI: 10.1007/S004249900211  0.502
2000 Rorsman P, Eliasson L, Renström E, Gromada J, Barg S, Göpel S. The cell physiology of biphasic insulin secretion News in Physiological Sciences. 15: 72-77.  0.42
1999 Rorsman P, Renström E. Glutamate primes the pump Nature. 402: 595-596. PMID 10604461 DOI: 10.1038/45110  0.392
1999 Göpel S, Kanno T, Barg S, Galvanovskis J, Rorsman P. Voltage-gated and resting membrane currents recorded from B-cells in intact mouse pancreatic islets Journal of Physiology. 521: 717-728. PMID 10601501 DOI: 10.1111/J.1469-7793.1999.00717.X  0.513
1999 Göpel SO, Kanno T, Barg S, Eliasson L, Galvanovskis J, Renström E, Rorsman P. Activation of Ca2+-dependent K+ channels contributes to rhythmic firing of action potentials in mouse pancreatic β cells Journal of General Physiology. 114: 759-769. PMID 10578013 DOI: 10.1085/Jgp.114.6.759  0.525
1999 Bokvist K, Olsen HL, Høy M, Gotfredsen CF, Holmes WF, Buschard K, Rorsman P, Gromada J. Characterisation of sulphonylurea and ATP-regulated K+ channels in rat pancreatic A-cells Pflugers Archiv European Journal of Physiology. 438: 428-436. PMID 10519134 DOI: 10.1007/S004249900076  0.406
1999 Gromada J, Høy M, Renström E, Bokvist K, Eliasson L, Göpel S, Rorsman P. CaM kinase II-dependent mobilization of secretory granules underlies acetylcholine-induced stimulation of exocytosis in mouse pancreatic B-cells Journal of Physiology. 518: 745-759. PMID 10420011 DOI: 10.1111/J.1469-7793.1999.0745P.X  0.502
1999 Barg S, Renstrom E, Berggren PO, Bertorello A, Bokvist K, Braun M, Eliasson L, Holmes WE, Kohler M, Rorsman P, Thevenod F. The stimulatory action of tolbutamide on Ca2+-dependent exocytosis in pancreatic β cells is mediated by a 65-kDa mdr-like P-glycoprotein Proceedings of the National Academy of Sciences of the United States of America. 96: 5539-5544. PMID 10318919 DOI: 10.1073/Pnas.96.10.5539  0.48
1999 Gall D, Gromada J, Susa I, Rorsman P, Herchuelz A, Bokvist K. Significance of Na/Ca exchange for Ca2+ buffering and electrical activity in mouse pancreatic β-cells Biophysical Journal. 76: 2018-2028. PMID 10096898 DOI: 10.1016/S0006-3495(99)77359-5  0.504
1999 Mulder H, Holst LS, Svensson H, Degerman E, Sundler F, Ahrén B, Rorsman P, Holm C. Hormone-sensitive lipase, the rate-limiting enzyme in triglyceride hydrolysis, is expressed and active in β-cells Diabetes. 48: 228-232. PMID 9892250 DOI: 10.2337/Diabetes.48.1.228  0.42
1999 Wiser O, Trus M, Hernandez A, Renstrom E, Barg S, Rorsman P, Atlas D. The voltage sensitive Lc-type Ca2+ channel is functionally coupled to the exocytotic machinery Proceedings of the National Academy of Sciences of the United States of America. 96: 248-253. PMID 9874804 DOI: 10.1073/Pnas.96.1.248  0.486
1998 Fuhlendorff J, Rorsman P, Kofod H, Brand CL, Rolin B, MacKay P, Shymko R, Carr RD. Stimulation of insulin release by repaglinide and glibenclamide involves both common and distinct processes. Diabetes. 47: 345-51. PMID 9519738 DOI: 10.2337/Diabetes.47.3.345  0.473
1998 Gromada J, Holst JJ, Rorsman P. Cellular regulation of islet hormone secretion by the incretin hormone glucagon-like peptide 1 Pflugers Archiv European Journal of Physiology. 435: 583-594. PMID 9479010 DOI: 10.1007/S004240050558  0.547
1998 Gromada J, Bokvist K, Ding WG, Holst JJ, Nielsen JH, Rorsman P. Glucagon-like peptide 1(7-36) amide stimulates exocytosis in human pancreatic β-cells by both proximal and distal regulatory steps in stimulus- secretion coupling Diabetes. 47: 57-65. PMID 9421375 DOI: 10.2337/Diab.47.1.57  0.55
1997 Eliasson L, Renström E, Ding WG, Proks P, Rorsman P. Rapid ATP-dependent priming of secretory granules precedes Ca2+-induced exocytosis in mouse pancreatic B-cells Journal of Physiology. 503: 399-412. PMID 9306281 DOI: 10.1111/J.1469-7793.1997.399Bh.X  0.557
1997 Gromada J, Bokvist K, Ding WG, Barg S, Buschard K, Renström E, Rorsman P. Adrenaline stimulates glucagon secretion in pancreatic A-cells by increasing the Ca2+ current and the number of granules close to the L-type Ca2+ channels Journal of General Physiology. 110: 217-228. PMID 9276750 DOI: 10.1085/Jgp.110.3.217  0.517
1997 Rorsman P. Electrophysiological studies of insulin secretion, physiology and pathophysiology | Elektrofysiologiska undersökningar av insulinfrisättningens fysiologi och patofysiologi Nordisk Medicin. 112: 164-168. PMID 9273507  0.513
1997 Rorsman P, Eliasson L, Renstrom E. Components of insulin secretion: Lessons to be learnt from capacitance Japanese Journal of Physiology. 47: S21. PMID 9266316  0.343
1997 Gromada J, Ding WG, Barg S, Renström E, Rorsman P. Multisite regulation of insulin secretion by cAMP-increasing agonists: Evidence that glucagon-like peptide 1 and glucagon act via distinct receptors Pflugers Archiv European Journal of Physiology. 434: 515-524. PMID 9242714 DOI: 10.1007/S004240050431  0.587
1997 Renström E, Eliasson L, Rorsman P. Protein kinase A-dependent and -independent stimulation of exocytosis by cAMP in mouse pancreatic B-cells Journal of Physiology. 502: 105-118. PMID 9234200 DOI: 10.1111/J.1469-7793.1997.105Bl.X  0.522
1997 Rorsman P. The pancreatic beta-cell as a fuel sensor: An electrophysiologist's viewpoint Diabetologia. 40: 487-495. PMID 9165215 DOI: 10.1007/S001250050706  0.555
1997 Ding WG, Renström E, Rorsman P, Buschard K, Gromada J. Glucagon-like peptide I and glucose-dependent insulinotropic polypeptide stimulate Ca2+-induced secretion in rat α-cells by a protein kinase A- mediated mechanism Diabetes. 46: 792-800. PMID 9133546 DOI: 10.2337/Diab.46.5.792  0.518
1997 Gilon P, Yakel J, Gromada J, Zhu Y, Henquin JC, Rorsman P. G protein-dependent inhibition of L-type Ca2+ currents by acetylcholine in mouse pancreatic B-cells. The Journal of Physiology. 499: 65-76. PMID 9061640  0.37
1996 Proks P, Eliasson L, Ämmälä C, Rorsman P, Ashcroft FM. Ca2+- and GTP-dependent exocytosis in mouse pancreatic β-cells involves both common and distinct steps Journal of Physiology. 496: 255-264. PMID 8910213 DOI: 10.1113/Jphysiol.1996.Sp021682  0.496
1996 Gromada J, Rorsman P. Molecular mechanism underlying glucagon-like peptide 1 induced calcium mobilization from internal stores in insulin-secreting βTC3 cells Acta Physiologica Scandinavica. 157: 349-351. PMID 8830891 DOI: 10.1046/J.1365-201X.1996.40255000.X  0.43
1996 Renström E, Ding WG, Bokvist K, Rorsman P. Neurotransmitter-induced inhibition of exocytosis in insulin-secreting β cells by activation of calcineurin Neuron. 17: 513-522. PMID 8816714 DOI: 10.1016/S0896-6273(00)80183-X  0.532
1996 Renström E, Eliasson L, Bokvist K, Rorsman P. Cooling inhibits exocytosis in single mouse pancreatic B-cells by suppression of granule mobilization Journal of Physiology. 494: 41-52. PMID 8814605 DOI: 10.1113/Jphysiol.1996.Sp021474  0.502
1996 Malaisse WJ, Lebrun P, Pirotte B, Van Poelje PD, Viñambres C, Villanueva-Peñacarillo ML, Valverde I, Gäbel J, Rorsman P. The riddle of formycin A insulinotropic action Biochemical and Molecular Medicine. 57: 47-63. PMID 8812726 DOI: 10.1006/Bmme.1996.0008  0.593
1996 Eliasson L, Proks P, Ammälä C, Ashcroft FM, Bokvist K, Renström E, Rorsman P, Smith PA. Endocytosis of secretory granules in mouse pancreatic beta-cells evoked by transient elevation of cytosolic calcium. The Journal of Physiology. 493: 755-67. PMID 8799897 DOI: 10.1113/Jphysiol.1996.Sp021420  0.504
1996 Gromada J, Dissing S, Rorsman P. Desensitization of glucagon-like peptide 1 receptors in insulin-secreting βTC3 cells: Role of PKA-independent mechanisms British Journal of Pharmacology. 118: 769-775. PMID 8762106 DOI: 10.1111/J.1476-5381.1996.Tb15466.X  0.529
1996 Eliasson L, Renström E, Ämmälä C, Berggren PO, Bertorello AM, Bokvist K, Chibalin A, Deeney JT, Flatt PR, Gäbel J, Gromada J, Larsson O, Lindström P, Rhodes CJ, Rorsman P. PKC-dependent stimulation of exocytosis by sulfonylureas in pancreatic β cells Science. 271: 813-815. PMID 8628999 DOI: 10.1126/Science.271.5250.813  0.522
1996 Lebrun P, Renström E, Antoine MH, Bokvist K, Holmquist M, Rorsman P, Malaisse WJ. Dynamics of the cationic, bioelectrical and secretory responses to formycin A in pancreatic islet cells Pflugers Archiv European Journal of Physiology. 431: 353-362. PMID 8584428 DOI: 10.1007/Bf02207272  0.597
1995 Bokvist K, Eliasson L, Ämmälä C, Renström E, Rorsman P. Co-localization of L-type Ca2+ channels and insulin-containing secretory granules and its significance for the initiation of exocytosis in mouse pancreatic B-cells Embo Journal. 14: 50-57. PMID 7828595 DOI: 10.1002/J.1460-2075.1995.Tb06974.X  0.519
1995 Gromada J, Dissing S, Bokvist K, Renström E, Frøkjser-Jensen J, Wulff BS, Rorsman P. Glucagon-like peptide I increases cytoplasmic calcium in insulin-secreting βTC3-cells by enhancement of intracellular calcium mobilization Diabetes. 44: 767-774. PMID 7789644 DOI: 10.2337/Diabetes.44.7.767  0.56
1995 Gromada J, Rorsman P, Dissing S, Wulff BS. Stimulation of cloned human glucagon-like peptide 1 receptor expressed in HEK 293 cells induces cAMP-dependent activation of calcium-induced calcium release Febs Letters. 373: 182-186. PMID 7589461 DOI: 10.1016/0014-5793(95)01070-U  0.444
1995 Fuhlendorff J, Carr R, Kofod H, Rorsman P. The mechanism of action of repaglinide differs to sulphonylureas in murine beta cells Pharmacological Research. 31: 32. DOI: 10.1016/1043-6618(95)86386-9  0.353
1994 Best L, Ammala C, Rorsman P, Tomlinson S. Intracellular pH, cytosolic calcium concentration and electrical activity in RINm5F insulinoma cells Bba - Biomembranes. 1192: 107-111. PMID 8204639 DOI: 10.1016/0005-2736(94)90149-X  0.415
1994 Ämmälä C, Eliasson L, Bokvist K, Berggren PO, Honkanen RE, Sjöholm A, Rorsman P. Activation of protein kinases and inhibition of protein phosphatases play a central role in the regulation of exocytosis in mouse pancreatic β cells Proceedings of the National Academy of Sciences of the United States of America. 91: 4343-4347. PMID 8183910 DOI: 10.1073/Pnas.91.10.4343  0.545
1994 Ashcroft FM, Proks P, Smith PA, Ammälä C, Bokvist K, Rorsman P. Stimulus-secretion coupling in pancreatic beta cells. Journal of Cellular Biochemistry. 55: 54-65. PMID 7929618 DOI: 10.1002/Jcb.240550007  0.571
1994 Ekmehag B, Persson B, Rorsman P, Rorsman H. Demonstration of voltage-dependent and TTX-sensitive Na(+)-channels in human melanocytes Pigment Cell Research / Sponsored by the European Society For Pigment Cell Research and the International Pigment Cell Society. 7: 333-338. PMID 7886006 DOI: 10.1111/J.1600-0749.1994.Tb00636.X  0.371
1994 Malaisse WJ, Conget I, Sener A, Rorsman P. Insulinotropic action of AICA riboside. II. Secretory, metabolic and cationic aspects Diabetes Research. 25: 25-37. PMID 7648779  0.398
1994 Rorsman P, Bokvist K, Ammala CD, Eliasson L, Renstrom E, Gabel J. Ion channels, electrical activity and insulin secretion Diabete Et Metabolisme. 20: 138-145. PMID 7528694  0.431
1993 Ämmälä C, Bokvist K, Larsson O, Berggren PO, Rorsman P. Demonstration of a novel apamin-insensitive calcium-activated K+ channel in mouse pancreatic B cells PflüGers Archiv European Journal of Physiology. 422: 443-448. PMID 8474849 DOI: 10.1007/Bf00375069  0.437
1993 Sjöholm A, Arkhammar P, Welsh N, Bokvist K, Rorsman P, Hallberg A, Nilsson T, Welsh M, Berggren PO. Enhanced stimulus-secretion coupling in polyamine-depleted rat insulinoma cells an effect involving increased cytoplasmic Ca2+, inositol phosphate generation, and phorbol ester sensitivity Journal of Clinical Investigation. 92: 1910-1917. PMID 8408643 DOI: 10.1172/Jci116784  0.598
1993 Larsson O, Ammala C, Bokvist K, Fredholm B, Rorsman P. Stimulation of the K(ATP) channel by adp and diazoxide requires nucleotide hydrolysis in mouse pancreatic β-cells Journal of Physiology. 463: 349-365. PMID 8246187 DOI: 10.1113/Jphysiol.1993.Sp019598  0.406
1993 Ammala C, Eliasson L, Bokvist K, Larsson O, Ashcroft FM, Rorsman P. Exocytosis elicited by action potentials and voltage-clamp calcium currents in individual mouse pancreatic B-cells Journal of Physiology. 472: 665-688. PMID 8145165 DOI: 10.1113/Jphysiol.1993.Sp019966  0.485
1993 Juntti-Berggren L, Larsson O, Rorsman P, Ämmälä C, Bokvist K, Wåhlander K, Nicotera P, Dypbukt J, Orrenius S, Hallberg A, Berggren PO. Increased activity of L-type Ca2+ channels exposed to serum from patients with type I diabetes Science. 261: 86-90. PMID 7686306 DOI: 10.1126/Science.7686306  0.529
1993 Ämmälä C, Ashcroft FM, Rorsman P. Calcium-independent potentiation of insulin release by cyclic AMP in single β-cells Nature. 363: 356-358. PMID 7684514 DOI: 10.1038/363356A0  0.598
1992 Rorsman P, Ämmälä C, Berggren PO, Bokvist K, Larsson O. Cytoplasmic calcium transients due to single action potentials and voltage-clamp depolarizations in mouse pancreatic B-cells Embo Journal. 11: 2877-2884. PMID 1639061 DOI: 10.1002/J.1460-2075.1992.Tb05356.X  0.472
1992 Islam MS, Rorsman P, Berggren PO. Ca2+-induced Ca2+ release in insulin-secreting cells Febs Letters. 296: 287-291. PMID 1537406 DOI: 10.1016/0014-5793(92)80306-2  0.505
1992 Juntti-Berggren L, Rorsman P, Siffert W, Berggren PO. Intracellular pH and the stimulus-secretion coupling in insulin-producing RINm5F cells Biochemical Journal. 287: 59-66. PMID 1417791 DOI: 10.1042/Bj2870059  0.563
1992 Ämmälä C, Berggren PO, Bokvist K, Rorsman P. Inhibition of L-type calcium channels by internal GTP [γS] in mouse pancreatic β cells PflüGers Archiv European Journal of Physiology. 420: 72-77. PMID 1313169 DOI: 10.1007/Bf00378643  0.502
1992 Kindmark H, Kohler M, Efendic S, Rorsman P, Larsson o, Berggren PO. Errata and corrigendaProtein kinase C activity affects glucose-induced oscillations in cytoplasmic free Ca2+ in the pancreatic B-cell Febs Letters. 305. DOI: 10.1016/0014-5793(92)80889-O  0.474
1992 Kindmark H, Kohler M, Efendic S, Rorsman P, Larsson o, Berggren PO. Protein kinase C activity affects glucose-induced oscillations in cytoplasmic free Ca2+ in the pancreatic B-cell Febs Letters. 305: 166. DOI: 10.1016/0014-5793(92)80483-W  0.497
1991 Ashcroft FM, Rorsman P. Electrophysiology of the pancreatic beta-cell. Progress in Biophysics and Molecular Biology. 54: 87-143. PMID 2484976 DOI: 10.1016/0079-6107(89)90013-8  0.373
1991 Ämmälä C, Bokvist K, Galt S, Rorsman P. Inhibition of ATP-regulated K+-channels by a photoactivatable ATP-analogue in mouse pancreatic β-cells Bba - Molecular Cell Research. 1092: 347-349. PMID 2049403 DOI: 10.1016/S0167-4889(97)90011-2  0.384
1991 Rorsman P, Ashcrof FM, Berggren PO. Regulation of glucagon release from pancreatic A-cells Biochemical Pharmacology. 41: 1783-1790. PMID 2039536 DOI: 10.1016/0006-2952(91)90116-M  0.404
1991 Kindmark H, Köhler M, Nilsson T, Arkhammar P, Wiechel KL, Rorsman P, Efendić S, Berggren PO. Measurements of cytoplasmic free Ca2+ concentration in human pancreatic islets and insulinoma cells Febs Letters. 291: 310-314. PMID 1936280 DOI: 10.1016/0014-5793(91)81309-V  0.51
1991 Rorsman P, Bokvist K, Ammälä C, Arkhammar P, Berggren PO, Larsson O, Wåhlander K. Activation by adrenaline of a low-conductance G protein-dependent K+ channel in mouse pancreatic B cells. Nature. 349: 77-9. PMID 1898674 DOI: 10.1038/349077A0  0.574
1991 Ämmälä C, Larsson O, Berggren PO, Bokvist K, Juntti-Berggren L, Kindmark H, Rorsman P. Inositol trisphosphate-dependent periodic activation of a Ca2+-activated K+ conductance in glucose-stimulated pancreatic β-cells Nature. 353: 849-852. PMID 1719424 DOI: 10.1038/353849A0  0.605
1991 Rorsman P, Fredholm BB. [Ion channels--the molecular background of neural transmission]. Lã¤Kartidningen. 88: 2868-77. PMID 1716716  0.316
1991 Juntti-Berggren L, Arkhammar P, Nilsson T, Rorsman P, Berggren PO. Glucose-induced increase in cytoplasmic pH in pancreatic β-cells is mediated by Na+/H+ exchange, an effect not dependent on protein kinase C Journal of Biological Chemistry. 266: 23537-23541. PMID 1660875  0.503
1991 Bokvist K, Ämmälä C, Berggren PO, Rorsman P, Wåhlander K. Alpha2-adrenoreceptor stimulation does not inhibit L-type calcium channels in mouse pancreatic β-cells Bioscience Reports. 11: 147-157. PMID 1659917 DOI: 10.1007/Bf01182483  0.521
1991 Islam MS, Nilsson T, Rorsman P, Berggren PO. Interaction with the inositol 1,4,5-trisphosphate receptor promotes Ca2+ sequestration in permeabilised insulin-secreting cells Febs Letters. 288: 27-29. PMID 1652478 DOI: 10.1016/0014-5793(91)80995-F  0.43
1990 Smith PA, Ashcroft FM, Rorsman P. Simultaneous recordings of glucose dependent electrical activity and ATP-regulated K(+)-currents in isolated mouse pancreatic beta-cells. Febs Letters. 261: 187-90. PMID 2407553 DOI: 10.1016/0014-5793(90)80667-8  0.497
1990 Arkhammar P, Hallberg A, Kindmark H, Nilsson T, Rorsman P, Berggren PO. Extracellular ATP increases cytoplasmic free Ca2+ concentration in clonal insulin-producing RINm5F cells. A mechanism involving direct interaction with both release and refilling of the inositol 1,4,5-trisphosphate-sensitive Ca2+ pool. The Biochemical Journal. 265: 203-11. PMID 2405836 DOI: 10.1042/Bj2650203  0.527
1990 Bokvist K, Rorsman P, Smith PA. Block of ATP-regulated and Ca2(+)-activated K+ channels in mouse pancreatic beta-cells by external tetraethylammonium and quinine. The Journal of Physiology. 423: 327-42. PMID 2201761 DOI: 10.1113/Jphysiol.1990.Sp018025  0.434
1990 Bokvist K, Rorsman P, Smith PA. Effects of external tetraethylammonium ions and quinine on delayed rectifying K+ channels in mouse pancreatic beta-cells. The Journal of Physiology. 423: 311-25. PMID 2201760 DOI: 10.1113/Jphysiol.1990.Sp018024  0.381
1990 Smith PA, Bokvist K, Arkhammar P, Berggren PO, Rorsman P. Delayed rectifying and calcium-activated K+ channels and their significance for action potential repolarization in mouse pancreatic beta-cells. The Journal of General Physiology. 95: 1041-59. PMID 2197368 DOI: 10.1085/Jgp.95.6.1041  0.476
1990 Berggren PO, Rorsman P, Arkhammar P, Nilsson T. Mechanisms of action of entero-insular hormones and neural input on the insulin secretory process. Biochemical Society Transactions. 18: 119-22. PMID 2185074 DOI: 10.1042/Bst0180119  0.401
1990 Ashcroft FM, Rorsman P. ATP-sensitive K+ channels: a link between B-cell metabolism and insulin secretion. Biochemical Society Transactions. 18: 109-11. PMID 2185070 DOI: 10.1042/Bst0180109  0.471
1990 Betsholtz C, Baumann A, Kenna S, Ashcroft FM, Ashcroft SJ, Berggren PO, Grupe A, Pongs O, Rorsman P, Sandblom J. Expression of voltage-gated K+ channels in insulin-producing cells. Analysis by polymerase chain reaction. Febs Letters. 263: 121-6. PMID 1691985 DOI: 10.1016/0014-5793(90)80719-Y  0.43
1990 Rorsman P, Berggren P, Bokvist K, Efendic S. ATP-Regulated K+ Channels and Diabetes Mellitus Physiology. 5: 143-147. DOI: 10.1152/Physiologyonline.1990.5.4.143  0.493
1989 Smith PA, Bokvist K, Rorsman P. Demonstration of A-currents in pancreatic islet cells. PflüGers Archiv : European Journal of Physiology. 413: 441-3. PMID 2648325 DOI: 10.1007/Bf00584497  0.33
1989 Rorsman P, Berggren PO, Bokvist K, Ericson H, Möhler H, Ostenson CG, Smith PA. Glucose-inhibition of glucagon secretion involves activation of GABAA-receptor chloride channels. Nature. 341: 233-6. PMID 2550826 DOI: 10.1038/341233A0  0.572
1989 Ashcroft FM, Rorsman P, Trube G. Single calcium channel activity in mouse pancreatic beta-cells. Annals of the New York Academy of Sciences. 560: 410-2. PMID 2545147 DOI: 10.1111/J.1749-6632.1989.Tb24123.X  0.398
1989 Findlay I, Ashcroft FM, Kelly RP, Rorsman P, Petersen OH, Trube G. Calcium currents in insulin-secreting beta-cells. Annals of the New York Academy of Sciences. 560: 403-9. PMID 2545146 DOI: 10.1111/J.1749-6632.1989.Tb24122.X  0.479
1989 Rorsman P, Arkhammar P, Bokvist K, Hellerström C, Nilsson T, Welsh M, Welsh N, Berggren PO. Failure of glucose to elicit a normal secretory response in fetal pancreatic beta cells results from glucose insensitivity of the ATP-regulated K+ channels. Proceedings of the National Academy of Sciences of the United States of America. 86: 4505-9. PMID 2543980 DOI: 10.1073/Pnas.86.12.4505  0.572
1989 Smith PA, Rorsman P, Ashcroft FM. Modulation of dihydropyridine-sensitive Ca2+ channels by glucose metabolism in mouse pancreatic beta-cells. Nature. 342: 550-3. PMID 2479839 DOI: 10.1038/342550A0  0.592
1989 Ahrén B, Berggren PO, Bokvist K, Rorsman P. Does galanin inhibit insulin secretion by opening of the ATP-regulated K+ channel in the beta-cell? Peptides. 10: 453-7. PMID 2474156 DOI: 10.1016/0196-9781(89)90058-2  0.542
1989 Rorsman P, Ashcroft FM, Trube G. Single Ca channel currents in mouse pancreatic B-cells. Pflugers Archiv : European Journal of Physiology. 412: 597-603. PMID 2463514 DOI: 10.1007/Bf00583760  0.494
1988 Ashcroft FM, Ashcroft SJ, Berggren PO, Betzholz C, Rorsman P, Trube G, Welsh M. Expression of K channels in Xenopus laevis oocytes injected with poly(A+) mRNA from the insulin-secreting beta-cell line, HIT T15. Febs Letters. 239: 185-9. PMID 2903072 DOI: 10.1016/0014-5793(88)80913-X  0.471
1988 Flatt PR, Abrahamsson H, Arkhammar P, Berggren PO, Rorsman P, Swanston-Flatt SK. Measurements of membrane potential, transmembrane 45Ca fluxes, cytoplasmic free Ca2+ concentration and insulin release by transplantable rat insulinoma cells maintained in tissue culture. British Journal of Cancer. 58: 22-9. PMID 2844219 DOI: 10.1038/Bjc.1988.154  0.53
1988 Rorsman P. Two types of Ca2+ currents with different sensitivities to organic Ca2+ channel antagonists in guinea pig pancreatic alpha 2 cells. The Journal of General Physiology. 91: 243-54. PMID 2453604 DOI: 10.1085/Jgp.91.2.243  0.447
1988 Rorsman P, Hellman B. Voltage-activated currents in guinea pig pancreatic alpha 2 cells. Evidence for Ca2+-dependent action potentials. The Journal of General Physiology. 91: 223-42. PMID 2453603 DOI: 10.1085/Jgp.91.2.223  0.46
1988 Ahrén B, Rorsman P, Berggren PO. Galanin and the endocrine pancreas. Febs Letters. 229: 233-7. PMID 2450047 DOI: 10.1016/0014-5793(88)81131-1  0.596
1987 Wesslén N, Pipeleers D, Van de Winkel M, Rorsman P, Hellman B. Glucose stimulates the entry of Ca2+ into the insulin-producing beta cells but not into the glucagon-producing alpha 2 cells. Acta Physiologica Scandinavica. 131: 230-4. PMID 3314351 DOI: 10.1111/J.1748-1716.1987.Tb08231.X  0.526
1987 Trube G, Rorsman P. Calcium and potassium currents recorded from pancreatic beta-cells under voltage clamp control. Advances in Experimental Medicine and Biology. 211: 167-75. PMID 2440242 DOI: 10.1007/978-1-4684-5314-0_14  0.501
1987 Rorsman P, Arkhammar P, Berggren PO. Voltage-activated Na+ currents and their suppression by phorbol ester in clonal insulin-producing RINm5F cells. The American Journal of Physiology. 251: C912-9. PMID 2431624 DOI: 10.1152/Ajpcell.1986.251.6.C912  0.417
1987 FLATT PR, RORSMAN P, SWANSTON-FLATT SK. EFFECTS OF CATIONIC MODIFICATION ON SUPERFICIAL BINDING AND INTRACELLULAR 45Ca UPTAKE BY DECAPSULATED OB/OB MOUSE PANCREATIC ISLETS Biomedical Research. 8: 153-159. DOI: 10.2220/Biomedres.8.153  0.444
1986 Arkhammar P, Berggren PO, Rorsman P. Direct evidence for opposite effects of D-glucose and D-glyceraldehyde on cytoplasmic pH of mouse pancreatic beta-cells. Bioscience Reports. 6: 355-61. PMID 3091112 DOI: 10.1007/Bf01116422  0.39
1986 Rorsman P, Abrahamsson H. Cyclic AMP potentiates glucose-induced insulin release from mouse pancreatic islets without increasing cytosolic free Ca2+. Acta Physiologica Scandinavica. 125: 639-47. PMID 3004107 DOI: 10.1111/J.1748-1716.1985.Tb07766.X  0.591
1986 Trube G, Rorsman P, Ohno-Shosaku T. Opposite effects of tolbutamide and diazoxide on the ATP-dependent K+ channel in mouse pancreatic beta-cells. PflüGers Archiv: European Journal of Physiology. 407: 493-499. PMID 2431383 DOI: 10.1007/Bf00657506  0.487
1986 Rorsman P, Trube G. Calcium and delayed potassium currents in mouse pancreatic beta-cells under voltage-clamp conditions. The Journal of Physiology. 374: 531-50. PMID 2427706 DOI: 10.1113/Jphysiol.1986.Sp016096  0.41
1986 Rorsman P, Trube G. Glucose dependent K+-channels in pancreatic beta-cells are regulated by intracellular ATP. Pflugers Archiv : European Journal of Physiology. 405: 305-9. PMID 2417189 DOI: 10.1007/Bf00595682  0.482
1986 GYLFE E, BERGGREN P, RORSMAN P. MEASUREMENTS OF CYTOPLASMIC pH IN INSULIN-RELEASING CELLS WITH INTRACELLULARLY TRAPPED PHENOL RED Biomedical Research. 7: 139-144. DOI: 10.2220/Biomedres.7.139  0.438
1985 Larsson R, Wallfelt C, Abrahamsson H, Gylfe E, Ljunghall S, Rastad J, Rorsman P, Wide L, Akerström G. Defective regulation of the cytosolic Ca2+ activity in parathyroid cells from patients with hyperparathyroidism. Bioscience Reports. 4: 909-15. PMID 6525449 DOI: 10.1007/Bf01116888  0.453
1985 Abrahamsson H, Berggren PO, Rorsman P. Direct measurements of increased free cytoplasmic Ca2+ in mouse pancreatic beta-cells following stimulation by hypoglycemic sulfonylureas. Febs Letters. 190: 21-4. PMID 2412893 DOI: 10.1016/0014-5793(85)80418-X  0.494
1984 Rorsman P, Abrahamsson H, Gylfe E, Hellman B. Dual effects of glucose on the cytosolic Ca2+ activity of mouse pancreatic beta-cells. Febs Letters. 170: 196-200. PMID 6373371 DOI: 10.1016/0014-5793(84)81398-8  0.502
1984 Rorsman P, Berggren PO, Gylfe E, Hellman B. Reduction of the cytosolic calcium activity in clonal insulin-releasing cells exposed to glucose. Bioscience Reports. 3: 939-46. PMID 6317080 DOI: 10.1007/Bf01140663  0.599
1984 Gylfe E, Andersson T, Rorsman P, Abrahamsson H, Arkhammar P, Hellman P, Hellman B, Oie HK, Gazdar AF. Depolarization-independent net uptake of calcium into clonal insulin-releasing cells exposed to glucose. Bioscience Reports. 3: 927-37. PMID 6317079 DOI: 10.1007/Bf01140662  0.544
1983 Rorsman P, Hellman B. The interaction between manganese and calcium fluxes in pancreatic beta-cells. The Biochemical Journal. 210: 307-14. PMID 6190477 DOI: 10.1042/Bj2100307  0.522
1982 Rorsman P, Berggren PO, Hellman B. Manganese accumulation in pancreatic beta-cells and its stimulation by glucose. The Biochemical Journal. 202: 435-44. PMID 7046732 DOI: 10.1042/Bj2020435  0.548
1981 Hellman B, Andersson T, Berggren PO, Rorsman P. Calcium and pancreatic beta-cell function. XI. Modification of 45Ca fluxes by Na+ removal. Biochemical Medicine. 24: 143-52. PMID 7006599 DOI: 10.1016/0006-2944(80)90005-8  0.525
1981 Hellman B, Gylfe E, Berggren PO, Andersson T, Abrahamsson H, Rorsman P, Betsholtz C. Ca2+ transport in pancreatic beta-cells during glucose stimulation of insulin secretion. Upsala Journal of Medical Sciences. 85: 321-9. PMID 6262985 DOI: 10.3109/03009738009179202  0.596
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