| Year |
Citation |
Score |
| 2020 |
Pottel J, Armstrong D, Zou L, Fekete A, Huang XP, Torosyan H, Bednarczyk D, Whitebread S, Bhhatarai B, Liang G, Jin H, Ghaemi SN, Slocum S, Lukacs KV, Irwin JJ, ... ... Urban L, et al. The activities of drug inactive ingredients on biological targets. Science (New York, N.Y.). 369: 403-413. PMID 32703874 DOI: 10.1126/Science.Aaz9906 |
0.319 |
|
| 2017 |
Maciejewski M, Lounkine E, Whitebread S, Farmer P, DuMouchel W, Shoichet BK, Urban L. Reverse translation of adverse event reports paves the way for de-risking preclinical off-targets. Elife. 6. PMID 28786378 DOI: 10.7554/Elife.25818 |
0.319 |
|
| 2016 |
Chen J, Varga A, Selvarajah S, Jenes A, Dienes B, Sousa-Valente J, Kulik A, Veress G, Brain SD, Baker D, Urban L, Mackie K, Nagy I. Spatial Distribution of the Cannabinoid Type 1 and Capsaicin Receptors May Contribute to the Complexity of Their Crosstalk. Scientific Reports. 6: 33307. PMID 27653550 DOI: 10.1038/Srep33307 |
0.33 |
|
| 2016 |
White JP, Cibelli M, Urban L, Nilius B, McGeown JG, Nagy I. TRPV4: Molecular Conductor of a Diverse Orchestra. Physiological Reviews. 96: 911-73. PMID 27252279 DOI: 10.1152/Physrev.00016.2015 |
0.301 |
|
| 2016 |
Whitebread S, Dumotier B, Armstrong D, Fekete A, Chen S, Hartmann A, Muller PY, Urban L. Secondary pharmacology: screening and interpretation of off-target activities-focus on translation. Drug Discovery Today. PMID 27140035 DOI: 10.1016/J.Drudis.2016.04.021 |
0.322 |
|
| 2014 |
Sousa-Valente J, Andreou AP, Urban L, Nagy I. Transient receptor potential ion channels in primary sensory neurons as targets for novel analgesics. British Journal of Pharmacology. 171: 2508-27. PMID 24283624 DOI: 10.1111/Bph.12532 |
0.339 |
|
| 2014 |
Urban L, Maciejewski M, Lounkine E, Whitebread S, Jenkins JL, Hamon J, Fekete A, Muller PY. Translation of off-target effects: Prediction of ADRs by integrated experimental and computational approach Toxicology Research. 3: 433-444. DOI: 10.1039/C4Tx00077C |
0.316 |
|
| 2012 |
Lounkine E, Keiser MJ, Whitebread S, Mikhailov D, Hamon J, Jenkins JL, Lavan P, Weber E, Doak AK, Côté S, Shoichet BK, Urban L. Large-scale prediction and testing of drug activity on side-effect targets. Nature. 486: 361-7. PMID 22722194 DOI: 10.1038/Nature11159 |
0.324 |
|
| 2011 |
Golden AP, Li N, Chen Q, Lee T, Nevill T, Cao X, Johnson J, Erdemli G, Ionescu-Zanetti C, Urban L, Holmqvist M. IonFlux: a microfluidic patch clamp system evaluated with human Ether-Ã -go-go related gene channel physiology and pharmacology. Assay and Drug Development Technologies. 9: 608-19. PMID 21561375 DOI: 10.1089/Adt.2010.0362 |
0.307 |
|
| 2011 |
White JP, Urban L, Nagy I. TRPV1 function in health and disease. Current Pharmaceutical Biotechnology. 12: 130-44. PMID 20932253 DOI: 10.2174/138920111793937844 |
0.336 |
|
| 2010 |
White JP, Cibelli M, Rei Fidalgo A, Paule CC, Noormohamed F, Urban L, Maze M, Nagy I. Role of transient receptor potential and acid-sensing ion channels in peripheral inflammatory pain. Anesthesiology. 112: 729-41. PMID 20179512 DOI: 10.1097/Aln.0B013E3181Ca3179 |
0.346 |
|
| 2009 |
Hamon J, Whitebread S, Techer-Etienne V, Le Coq H, Azzaoui K, Urban L. In vitro safety pharmacology profiling: what else beyond hERG? Future Medicinal Chemistry. 1: 645-65. PMID 21426031 DOI: 10.4155/Fmc.09.51 |
0.316 |
|
| 2009 |
Scheiber J, Chen B, Milik M, Sukuru SC, Bender A, Mikhailov D, Whitebread S, Hamon J, Azzaoui K, Urban L, Glick M, Davies JW, Jenkins JL. Gaining insight into off-target mediated effects of drug candidates with a comprehensive systems chemical biology analysis. Journal of Chemical Information and Modeling. 49: 308-17. PMID 19434832 DOI: 10.1021/Ci800344P |
0.307 |
|
| 2008 |
Scheiber J, Jenkins J, Bender A, Whitebread S, Hamon J, Urban L, Azzaoui K, Glick M, Davies J. Side effect profile prediction - early addressing of big pharma's worst nightmare Chemistry Central Journal. 2: 1-1. DOI: 10.1186/1752-153X-2-S1-S4 |
0.322 |
|
| 2007 |
Wang J, Urban L, Bojanic D. Maximising use of in vitro ADMET tools to predict in vivo bioavailability and safety. Expert Opinion On Drug Metabolism & Toxicology. 3: 641-65. PMID 17916053 DOI: 10.1517/17425255.3.5.641 |
0.308 |
|
| 2007 |
Azzaoui K, Hamon J, Faller B, Whitebread S, Jacoby E, Bender A, Jenkins JL, Urban L. Modeling promiscuity based on in vitro safety pharmacology profiling data. Chemmedchem. 2: 874-80. PMID 17492703 DOI: 10.1002/Cmdc.200700036 |
0.301 |
|
| 2007 |
Bender A, Scheiber J, Glick M, Davies JW, Azzaoui K, Hamon J, Urban L, Whitebread S, Jenkins JL. Analysis of pharmacology data and the prediction of adverse drug reactions and off-target effects from chemical structure. Chemmedchem. 2: 861-73. PMID 17477341 DOI: 10.1002/Cmdc.200700026 |
0.338 |
|
| 2005 |
Whitebread S, Hamon J, Bojanic D, Urban L. Keynote review: in vitro safety pharmacology profiling: an essential tool for successful drug development. Drug Discovery Today. 10: 1421-33. PMID 16243262 DOI: 10.1016/S1359-6446(05)03632-9 |
0.344 |
|
| 2004 |
Nagy I, Sántha P, Jancsó G, Urbán L. The role of the vanilloid (capsaicin) receptor (TRPV1) in physiology and pathology. European Journal of Pharmacology. 500: 351-69. PMID 15464045 DOI: 10.1016/J.Ejphar.2004.07.037 |
0.325 |
|
| 2004 |
Dang K, Bowery NG, Urban L. Interaction of gamma-aminobutyric acid receptor type B receptors and calcium channels in nociceptive transmission studied in the mouse hemisected spinal cord in vitro: withdrawal symptoms related to baclofen treatment. Neuroscience Letters. 361: 72-5. PMID 15135896 DOI: 10.1016/J.Neulet.2003.12.009 |
0.334 |
|
| 2003 |
Ahluwalia J, Urban L, Bevan S, Nagy I. Anandamide regulates neuropeptide release from capsaicin-sensitive primary sensory neurons by activating both the cannabinoid 1 receptor and the vanilloid receptor 1 in vitro. The European Journal of Neuroscience. 17: 2611-8. PMID 12823468 DOI: 10.1046/J.1460-9568.2003.02703.X |
0.339 |
|
| 2003 |
Ahluwalia J, Yaqoob M, Urban L, Bevan S, Nagy I. Activation of capsaicin-sensitive primary sensory neurones induces anandamide production and release. Journal of Neurochemistry. 84: 585-91. PMID 12558978 DOI: 10.1046/J.1471-4159.2003.01550.X |
0.33 |
|
| 2003 |
Walker KM, Urban L, Medhurst SJ, Patel S, Panesar M, Fox AJ, McIntyre P. The VR1 antagonist capsazepine reverses mechanical hyperalgesia in models of inflammatory and neuropathic pain. The Journal of Pharmacology and Experimental Therapeutics. 304: 56-62. PMID 12490575 DOI: 10.1124/Jpet.102.042010 |
0.355 |
|
| 2002 |
Dang K, Naeem S, Walker K, Bowery NG, Urban L. Interaction of group I mGlu and NMDA receptor agonists within the dorsal horn of the spinal cord of the juvenile rat. British Journal of Pharmacology. 136: 248-54. PMID 12010773 DOI: 10.1038/Sj.Bjp.0704698 |
0.355 |
|
| 2002 |
Ahluwalia J, Urban L, Bevan S, Capogna M, Nagy I. Cannabinoid 1 receptors are expressed by nerve growth factor- and glial cell-derived neurotrophic factor-responsive primary sensory neurones. Neuroscience. 110: 747-53. PMID 11934481 DOI: 10.1016/S0306-4522(01)00601-7 |
0.333 |
|
| 2001 |
Morisset V, Ahluwalia J, Nagy I, Urban L. Possible mechanisms of cannabinoid-induced antinociception in the spinal cord. European Journal of Pharmacology. 429: 93-100. PMID 11698030 DOI: 10.1016/S0014-2999(01)01309-7 |
0.382 |
|
| 2001 |
Morisset V, Urban L. Cannabinoid-induced presynaptic inhibition of glutamatergic EPSCs in substantia gelatinosa neurons of the rat spinal cord. Journal of Neurophysiology. 86: 40-8. PMID 11431486 DOI: 10.1152/Jn.2001.86.1.40 |
0.379 |
|
| 2001 |
Fox A, Kesingland A, Gentry C, McNair K, Patel S, Urban L, James I. The role of central and peripheral Cannabinoid1 receptors in the antihyperalgesic activity of cannabinoids in a model of neuropathic pain. Pain. 92: 91-100. PMID 11323130 DOI: 10.1016/S0304-3959(00)00474-7 |
0.362 |
|
| 2001 |
Patel S, Naeem S, Kesingland A, Froestl W, Capogna M, Urban L, Fox A. The effects of GABA(B) agonists and gabapentin on mechanical hyperalgesia in models of neuropathic and inflammatory pain in the rat. Pain. 90: 217-26. PMID 11207393 DOI: 10.1016/S0304-3959(00)00404-8 |
0.358 |
|
| 2001 |
Walker K, Reeve A, Bowes M, Winter J, Wotherspoon G, Davis A, Schmid P, Gasparini F, Kuhn R, Urban L. mGlu5 receptors and nociceptive function II. mGlu5 receptors functionally expressed on peripheral sensory neurones mediate inflammatory hyperalgesia. Neuropharmacology. 40: 10-19. PMID 11077066 DOI: 10.1016/S0028-3908(00)00114-3 |
0.379 |
|
| 2001 |
Walker K, Bowes M, Panesar M, Davis A, Gentry C, Kesingland A, Gasparini F, Spooren W, Stoehr N, Pagano A, Flor PJ, Vranesic I, Lingenhoehl K, Johnson EC, Varney M, ... Urban L, et al. Metabotropic glutamate receptor subtype 5 (mGlu5) and nociceptive function. I. Selective blockade of mGlu5 receptors in models of acute, persistent and chronic pain. Neuropharmacology. 40: 1-9. PMID 11077065 DOI: 10.1016/S0028-3908(00)00113-1 |
0.358 |
|
| 2001 |
Fox A, Kesingland A, Gentry C, McNair K, Patel S, Urban L, James I. The role of central and peripheral Cannabinoid1 receptors in the antihyperalgesic activity of cannabinoids in a model of neuropathic pain. (Novartic Institute for Medical Sciences, London, United Kingdom) Pain. 2001;92:91-100. Pain Practice. 1: 375-376. DOI: 10.1046/J.1533-2500.2001.1039_18.X |
0.363 |
|
| 2001 |
Urban L, Nagy I, Bevan SJ. Chronic neuropathic pain: Pathomechanism and pharmacology Drug Development Research. 54: 159-166. DOI: 10.1002/Ddr.10015 |
0.366 |
|
| 2000 |
Urban L, Campbell EA, Panesar M, Patel S, Chaudhry N, Kane S, Buchheit K, Sandells B, James IF. In vivo pharmacology of SDZ 249-665, a novel, non-pungent capsaicin analogue. Pain. 89: 65-74. PMID 11113294 DOI: 10.1016/S0304-3959(00)00349-3 |
0.361 |
|
| 2000 |
Reeve AJ, Walker K, Urban L, Fox A. Excitatory effects of galanin in the spinal cord of intact, anaesthetized rats. Neuroscience Letters. 295: 25-28. PMID 11078928 DOI: 10.1016/S0304-3940(00)01576-7 |
0.325 |
|
| 2000 |
Ahluwalia J, Urban L, Capogna M, Bevan S, Nagy I. Cannabinoid 1 receptors are expressed in nociceptive primary sensory neurons. Neuroscience. 100: 685-8. PMID 11036202 DOI: 10.1016/S0306-4522(00)00389-4 |
0.343 |
|
| 2000 |
Towers S, Princivalle A, Billinton A, Edmunds M, Bettler B, Urban L, Castro-Lopes J, Bowery NG. GABAB receptor protein and mRNA distribution in rat spinal cord and dorsal root ganglia. The European Journal of Neuroscience. 12: 3201-10. PMID 10998104 DOI: 10.1046/J.1460-9568.2000.00237.X |
0.329 |
|
| 2000 |
Reeve AJ, Patel S, Fox A, Walker K, Urban L. Intrathecally administered endotoxin or cytokines produce allodynia, hyperalgesia and changes in spinal cord neuronal responses to nociceptive stimuli in the rat. European Journal of Pain. 4: 247-257. PMID 10985868 DOI: 10.1053/Eujp.2000.0177 |
0.319 |
|
| 2000 |
Campbell EA, Gentry C, Patel S, Kidd B, Cruwys S, Fox AJ, Urban L. Oral anti-hyperalgesic and anti-inflammatory activity of NK(1) receptor antagonists in models of inflammatory hyperalgesia of the guinea-pig. Pain. 87: 253-63. PMID 10963905 DOI: 10.1016/S0304-3959(00)00288-8 |
0.331 |
|
| 2000 |
Kesingland AC, Gentry CT, Panesar MS, Bowes MA, Vernier JM, Cube R, Walker K, Urban L. Analgesic profile of the nicotinic acetylcholine receptor agonists, (+)-epibatidine and ABT-594 in models of persistent inflammatory and neuropathic pain. Pain. 86: 113-8. PMID 10779668 DOI: 10.1016/S0304-3959(00)00233-5 |
0.346 |
|
| 2000 |
Burgess GM, Perkins MN, Rang HP, Campbell EA, Brown MC, McIntyre P, Urban L, Dziadulewicz EK, Ritchie TJ, Hallett A, Snell CR, Wrigglesworth R, Lee W, Davis C, Phagoo SB, et al. Bradyzide, a potent non-peptide B(2) bradykinin receptor antagonist with long-lasting oral activity in animal models of inflammatory hyperalgesia. British Journal of Pharmacology. 129: 77-86. PMID 10694205 DOI: 10.1038/Sj.Bjp.0703012 |
0.337 |
|
| 2000 |
Hao JX, Xu XJ, Urban L, Wiesenfeld-Hallin Z. Repeated administration of systemic gabapentin alleviates allodynia-like behaviors in spinally injured rats. Neuroscience Letters. 280: 211-4. PMID 10675798 DOI: 10.1016/S0304-3940(00)00787-4 |
0.334 |
|
| 1999 |
Polgár E, Szücs P, Urbán L, Matesz K, Nagy I. Immunohistochemical localization of neurokinin-l receptor in the lumbar spinal cord of young rats: morphology and distribution. Somatosensory & Motor Research. 16: 361-8. PMID 10632032 DOI: 10.1080/08990229970410 |
0.325 |
|
| 1999 |
Fox A, Eastwood C, Gentry C, Manning D, Urban L. Critical evaluation of the streptozotocin model of painful diabetic neuropathy in the rat. Pain. 81: 307-16. PMID 10431718 DOI: 10.1016/S0304-3959(99)00024-X |
0.314 |
|
| 1998 |
Campbell EA, Gentry CT, Patel S, Panesar MS, Walpole CS, Urban L. Selective neurokinin-1 receptor antagonists are anti-hyperalgesic in a model of neuropathic pain in the guinea-pig. Neuroscience. 87: 527-32. PMID 9758219 DOI: 10.1016/S0306-4522(98)00318-2 |
0.374 |
|
| 1998 |
Rees H, Sluka KA, Urban L, Walpole CJ, Willis WD. The effects of SDZ NKT 343, a potent NK1 receptor antagonist, on cutaneous responses of primate spinothalamic tract neurones sensitized by intradermal capsaicin injection. Experimental Brain Research. 121: 355-8. PMID 9746141 DOI: 10.1007/S002210050468 |
0.365 |
|
| 1998 |
Boxall SJ, Berthele A, Tölle TR, Zieglgänsberger W, Urban L. mGluR activation reveals a tonic NMDA component in inflammatory hyperalgesia. Neuroreport. 9: 1201-1203. PMID 9601694 DOI: 10.1097/00001756-199804200-00044 |
0.349 |
|
| 1998 |
Polgár E, Szûcs P, Urbán L, Nagy I. Alterations of substance P immunoreactivity in lumbar and thoracic segments of rat spinal cord in ultraviolet irradiation induced hyperalgesia of the hindpaw. Brain Research. 786: 248-51. PMID 9555041 DOI: 10.1016/S0006-8993(97)01434-0 |
0.306 |
|
| 1998 |
Hua XY, Chen P, Polgar E, Nagy I, Marsala M, Phillips E, Wollaston L, Urban L, Yaksh TL, Webb M. Spinal neurokinin NK1 receptor down-regulation and antinociception: effects of spinal NK1 receptor antisense oligonucleotides and NK1 receptor occupancy. Journal of Neurochemistry. 70: 688-98. PMID 9453563 DOI: 10.1046/J.1471-4159.1998.70020688.X |
0.369 |
|
| 1997 |
Boxall SJ, Berthele A, Laurie DJ, Sommer B, Zieglgänsberger W, Urban L, Tölle TR. Enhanced expression of metabotropic glutamate receptor 3 messenger RNA in the rat spinal cord during ultraviolet irradiation induced peripheral inflammation. Neuroscience. 82: 591-602. PMID 9466463 DOI: 10.1016/S0306-4522(97)00246-7 |
0.334 |
|
| 1997 |
Urban L, Nagy I. Is there a nociceptive carousel? Trends in Pharmacological Sciences. 18: 223-4. PMID 9253850 DOI: 10.1016/S0165-6147(97)01081-X |
0.329 |
|
| 1997 |
Pórszász R, Beckmann N, Bruttel K, Urban L, Rudin M. Signal changes in the spinal cord of the rat after injection of formalin into the hindpaw: Characterization using functional magnetic resonance imaging Proceedings of the National Academy of Sciences of the United States of America. 94: 5034-5039. PMID 9144185 DOI: 10.1073/Pnas.94.10.5034 |
0.32 |
|
| 1996 |
Davis CL, Naeem S, Phagoo SB, Campbell EA, Urban L, Burgess GM. B1 bradykinin receptors and sensory neurones. British Journal of Pharmacology. 118: 1469-76. PMID 8832074 DOI: 10.1111/J.1476-5381.1996.Tb15562.X |
0.376 |
|
| 1995 |
Thompson SW, Dray A, McCarson KE, Krause JE, Urban L. Nerve growth factor induces mechanical allodynia associated with novel A fibre-evoked spinal reflex activity and enhanced neurokinin-1 receptor activation in the rat. Pain. 62: 219-31. PMID 8545148 DOI: 10.1016/0304-3959(94)00271-F |
0.353 |
|
| 1995 |
Rang HP, Urban L. New molecules in analgesia British Journal of Anaesthesia. 75: 145-156. PMID 7577248 DOI: 10.1093/Bja/75.2.145 |
0.348 |
|
| 1995 |
Babbedge R, Dray A, Urban L. Bradykinin depolarises the rat isolated superior cervical ganglion via B2 receptor activation Neuroscience Letters. 193: 161-164. PMID 7478173 DOI: 10.1016/0304-3940(95)11690-X |
0.337 |
|
| 1994 |
Dray A, Urban L, Dickenson A. Pharmacology of chronic pain Trends in Pharmacological Sciences. 15: 190-197. PMID 8091514 DOI: 10.1016/0165-6147(94)90147-3 |
0.344 |
|
| 1994 |
Nagy I, Woolf CJ, Dray A, Urbán L. Cobalt accumulation in neurons expressing ionotropic excitatory amino acid receptors in young rat spinal cord: morphology and distribution. The Journal of Comparative Neurology. 344: 321-35. PMID 8063957 DOI: 10.1002/Cne.903440302 |
0.352 |
|
| 1994 |
Rueff A, Patel IA, Urban L, Dray A. Regulation of bradykinin sensitivity in peripheral sensory fibres of the neonatal rat by nitric oxide and cyclic GMP. Neuropharmacology. 33: 1139-45. PMID 7862249 DOI: 10.1016/S0028-3908(05)80003-6 |
0.34 |
|
| 1994 |
Urban L, Thompson SW, Dray A. Modulation of spinal excitability: co-operation between neurokinin and excitatory amino acid neurotransmitters. Trends in Neurosciences. 17: 432-8. PMID 7530882 DOI: 10.1016/0166-2236(94)90018-3 |
0.371 |
|
| 1994 |
Urban L, Naeem S, Patel IA, Dray A. Tachykinin induced regulation of excitatory amino acid responses in the rat spinal cord in vitro. Neuroscience Letters. 168: 185-8. PMID 7518061 DOI: 10.1016/0304-3940(94)90446-4 |
0.359 |
|
| 1993 |
Urban L, Perkins MN, Campbell E, Dray A. Activity of deep dorsal horn neurons in the anaesthetized rat during hyperalgesia of the hindpaw induced by ultraviolet irradiation Neuroscience. 57: 167-172. PMID 8278050 DOI: 10.1016/0306-4522(93)90118-Y |
0.325 |
|
| 1993 |
Fox AJ, Barnes PJ, Urban L, Dray A. An in vitro study of the properties of single vagal afferents innervating guinea-pig airways. The Journal of Physiology. 469: 21-35. PMID 8271198 DOI: 10.1113/Jphysiol.1993.Sp019802 |
0.307 |
|
| 1993 |
Jeftinija S, Urban L, Kojic L. The selective activation of dorsal horn neurons by potassium stimulation of high threshold primary afferent neurons in vitro Neuroscience. 56: 473-484. PMID 8247274 DOI: 10.1016/0306-4522(93)90347-I |
0.329 |
|
| 1993 |
Urban L, Dray A, Nagy I, Maggi CA. The effects of NK-1 and NK-2 receptor antagonists on the capsaicin evoked synaptic response in the rat spinal cord in vitro. Regulatory Peptides. 46: 413-4. PMID 7692552 DOI: 10.1016/0167-0115(93)90104-G |
0.347 |
|
| 1991 |
Urban L, Dray A. Capsazepine, a novel capsaicin antagonist, selectively antagonises the effects of capsaicin in the mouse spinal cord in vitro Neuroscience Letters. 134: 9-11. PMID 1726117 DOI: 10.1016/0304-3940(91)90496-G |
0.354 |
|
| 1989 |
Urban L, Willetts J, Murase K, Randić M. Cholinergic effects on spinal dorsal horn neurons in vitro: an intracellular study. Brain Research. 500: 12-20. PMID 2605485 DOI: 10.1016/0006-8993(89)90294-1 |
0.338 |
|
| 1984 |
Urbán L, Randić M. Slow excitatory transmission in rat dorsal horn: possible mediation by peptides. Brain Research. 290: 336-41. PMID 6198043 DOI: 10.1016/0006-8993(84)90952-1 |
0.336 |
|
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