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Liaoyuan Hu - Publications

Affiliations: 
Duke University, Durham, NC 
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15/34 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2020 Wang J, Song X, Zhang D, Chen X, Li X, Sun Y, Li C, Song Y, Ding Y, Ren R, Harrington EH, Hu LA, Zhong W, Xu C, Huang X, et al. Cryo-EM structures of PAC1 receptor reveal ligand binding mechanism. Cell Research. PMID 32047270 DOI: 10.1038/S41422-020-0280-2  0.313
2020 Ma Y, Ding Y, Song X, Ma X, Li X, Zhang N, Song Y, Sun Y, Shen Y, Zhong W, Hu LA, Ma Y, Zhang MY. Structure-guided discovery of a single-domain antibody agonist against human apelin receptor. Science Advances. 6: eaax7379. PMID 31998837 DOI: 10.1126/sciadv.aax7379  0.357
2019 Chen X, Xu Y, Qu L, Wu L, Han GW, Guo Y, Wu Y, Zhou Q, Sun Q, Chu C, Yang J, Yang L, Wang Q, Yuan S, Wang L, ... ... Hu L, et al. Molecular Mechanism for Ligand Recognition and Subtype Selectivity of α Adrenergic Receptor. Cell Reports. 29: 2936-2943.e4. PMID 31801061 DOI: 10.1016/J.Celrep.2019.10.112  0.395
2018 Ban T, Li X, Ma X, Yang H, Song Y, Sun Y, Shen M, Li N, Zhang MY, Ma Y, Zhong W, Zhang M, Hu LA. GPCR structure and function relationship: identification of a biased apelin receptor mutant. The Biochemical Journal. PMID 30409826 DOI: 10.1042/BCJ20180740  0.433
2009 Hu LA, Zhou T, Ahn J, Wang S, Zhou J, Hu Y, Liu Q. Human and mouse trace amine-associated receptor 1 have distinct pharmacology towards endogenous monoamines and imidazoline receptor ligands. The Biochemical Journal. 424: 39-45. PMID 19725810 DOI: 10.1042/BJ20090998  0.475
2009 Hu LA, Tang PM, Eslahi NK, Zhou T, Barbosa J, Liu Q. Identification of surrogate agonists and antagonists for orphan G-protein-coupled receptor GPR139. Journal of Biomolecular Screening. 14: 789-97. PMID 19525486 DOI: 10.1177/1087057109335744  0.388
2008 Hu LA, Zhou T, Hamman BD, Liu Q. A homogeneous G protein-coupled receptor ligand binding assay based on time-resolved fluorescence resonance energy transfer. Assay and Drug Development Technologies. 6: 543-50. PMID 18699727 DOI: 10.1089/adt.2008.152  0.339
2003 Chen W, ten Berge D, Brown J, Ahn S, Hu LA, Miller WE, Caron MG, Barak LS, Nusse R, Lefkowitz RJ. Dishevelled 2 recruits beta-arrestin 2 to mediate Wnt5A-stimulated endocytosis of Frizzled 4. Science (New York, N.Y.). 301: 1391-4. PMID 12958364 DOI: 10.1126/Science.1082808  0.808
2003 Hu LA, Chen W, Martin NP, Whalen EJ, Premont RT, Lefkowitz RJ. GIPC interacts with the beta1-adrenergic receptor and regulates beta1-adrenergic receptor-mediated ERK activation. The Journal of Biological Chemistry. 278: 26295-301. PMID 12724327 DOI: 10.1074/Jbc.M212352200  0.777
2002 Hu LA, Chen W, Premont RT, Cong M, Lefkowitz RJ. G protein-coupled receptor kinase 5 regulates beta 1-adrenergic receptor association with PSD-95. The Journal of Biological Chemistry. 277: 1607-13. PMID 11700307 DOI: 10.1074/Jbc.M107297200  0.819
2001 Chen W, Hu LA, Semenov MV, Yanagawa S, Kikuchi A, Lefkowitz RJ, Miller WE. beta-Arrestin1 modulates lymphoid enhancer factor transcriptional activity through interaction with phosphorylated dishevelled proteins. Proceedings of the National Academy of Sciences of the United States of America. 98: 14889-94. PMID 11742073 DOI: 10.1073/Pnas.211572798  0.792
2001 Cong M, Perry SJ, Hu LA, Hanson PI, Claing A, Lefkowitz RJ. Binding of the beta2 adrenergic receptor to N-ethylmaleimide-sensitive factor regulates receptor recycling. The Journal of Biological Chemistry. 276: 45145-52. PMID 11577089 DOI: 10.1074/Jbc.M106087200  0.766
2001 Cong M, Perry SJ, Lin FT, Fraser ID, Hu LA, Chen W, Pitcher JA, Scott JD, Lefkowitz RJ. Regulation of membrane targeting of the G protein-coupled receptor kinase 2 by protein kinase A and its anchoring protein AKAP79. The Journal of Biological Chemistry. 276: 15192-9. PMID 11278469 DOI: 10.1074/jbc.M009130200  0.735
2000 Hu LA, Tang Y, Miller WE, Cong M, Lau AG, Lefkowitz RJ, Hall RA. beta 1-adrenergic receptor association with PSD-95. Inhibition of receptor internalization and facilitation of beta 1-adrenergic receptor interaction with N-methyl-D-aspartate receptors. The Journal of Biological Chemistry. 275: 38659-66. PMID 10995758 DOI: 10.1074/Jbc.M005938200  0.784
1999 Tang Y, Hu LA, Miller WE, Ringstad N, Hall RA, Pitcher JA, DeCamilli P, Lefkowitz RJ. Identification of the endophilins (SH3p4/p8/p13) as novel binding partners for the beta1-adrenergic receptor. Proceedings of the National Academy of Sciences of the United States of America. 96: 12559-64. PMID 10535961 DOI: 10.1073/Pnas.96.22.12559  0.798
Low-probability matches (unlikely to be authored by this person)
2019 Li Y, Sun Y, Song Y, Dai D, Zhao Z, Zhang Q, Zhong W, Hu LA, Ma Y, Li X, Wang R. A Fragment-Based Computational Method for Designing GPCR Ligands. Journal of Chemical Information and Modeling. PMID 31652060 DOI: 10.1021/Acs.Jcim.9B00699  0.288
2020 Wang J, Song X, Zhang D, Chen X, Li X, Sun Y, Li C, Song Y, Ding Y, Ren R, Harrington EH, Hu LA, Zhong W, Xu C, Huang X, et al. Author Correction: Cryo-EM structures of PAC1 receptor reveal ligand binding mechanism. Cell Research. PMID 32203135 DOI: 10.1038/S41422-020-0307-8  0.287
2017 Ma Y, Yue Y, Ma Y, Zhang Q, Zhou Q, Song Y, Shen Y, Li X, Ma X, Li C, Hanson MA, Han GW, Sickmier EA, Swaminath G, Zhao S, ... ... Hu LA, et al. Structural Basis for Apelin Control of the Human Apelin Receptor. Structure (London, England : 1993). PMID 28528775 DOI: 10.1016/J.Str.2017.04.008  0.263
2022 Zhao W, Han S, Qiu N, Feng W, Lu M, Zhang W, Wang M, Zhou Q, Chen S, Xu W, Du J, Chu X, Yi C, Dai A, Hu L, et al. Structural insights into ligand recognition and selectivity of somatostatin receptors. Cell Research. PMID 35739238 DOI: 10.1038/s41422-022-00679-x  0.238
2020 Ren H, Li J, Zhang N, Hu LA, Ma Y, Tagari P, Xu J, Zhang MY. Function-based high-throughput screening for antibody antagonists and agonists against G protein-coupled receptors. Communications Biology. 3: 146. PMID 32218528 DOI: 10.1038/s42003-020-0867-7  0.225
2022 Liu Y, Ma X, Yang H, Li X, Ma Y, Ason B, Liu S, Hu L. APLNR regulates IFN-γ signaling via β-arrestin 1 mediated JAK-STAT1 pathway in melanoma cells. The Biochemical Journal. PMID 35084016 DOI: 10.1042/BCJ20210813  0.216
2020 Li N, Ma X, Ban T, Xu S, Ma Y, Ason B, Hu LA. Loss of APJ mediated β-arrestin signalling improves high-fat diet induced metabolic dysfunction but does not alter cardiac function in mice. The Biochemical Journal. PMID 32779693 DOI: 10.1042/BCJ20200343  0.206
2020 Ason B, Chen Y, Guo Q, Hoagland KM, Chui RW, Fielden M, Sutherland W, Chen R, Zhang Y, Mihardja S, Ma X, Li X, Sun Y, Liu D, Nguyen K, ... ... Hu LA, et al. Cardiovascular response to small molecule APJ activation. Jci Insight. PMID 32208384 DOI: 10.1172/Jci.Insight.132898  0.141
1998 Hu LA, King SC. Functional significance of the 'signature cysteine' in helix 8 of the Escherichia coli 4-aminobutyrate transporter from the amine-polyamine- choline superfamily. Restoration of Cys-300 to the Cys-less GabP Journal of Biological Chemistry. 273: 20162-20167. PMID 9685361 DOI: 10.1074/jbc.273.32.20162  0.131
1998 Hu LA, King SC. Membrane topology of the Escherichia coli γ-aminobutyrate transporter: Implications on the topography and mechanism of prokaryotic and eukaryotic transporters from the APC superfamily Biochemical Journal. 336: 69-76. PMID 9806886 DOI: 10.1042/BJ3360069  0.13
2021 Chen D, Zhao Y, Li M, Shang H, Li N, Li F, Wang W, Wang Y, Jin R, Liu S, Li X, Gao S, Tian Y, Li R, Li H, ... ... Hu LA, et al. A general Fc engineering platform for the next generation of antibody therapeutics. Theranostics. 11: 1901-1917. PMID 33408788 DOI: 10.7150/thno.51299  0.122
1998 Hu LA, King SC. Functional sensitivity of polar surfaces on transmembrane helix 8 and cytoplasmic loop 8-9 of the Escherichia coli GABA (4-aminobutyrate) transporter encoded by gabP: Mutagenic analysis of a consensus amphipathic region found in transporters from bacteria to mammals Biochemical Journal. 330: 771-776. PMID 9480889 DOI: 10.1042/BJ3300771  0.106
2003 King SC, Hu LA, Pugh A. Induction of substrate specificity shifts by placement of alanine insertions within the consensus amphipathic region of the Escherichia coli GABA (γ-aminobutyric acid) transporter encoded by gabP Biochemical Journal. 376: 645-653. PMID 12956623 DOI: 10.1042/BJ20030595  0.089
2016 Du Z, Caenepeel S, Shen Y, Rex K, Zhang Y, He Y, Tang ET, Wang O, Zhong W, Zhou H, Huang J, Huang E, Hu L, Coxon A, Zhang M. Preclinical Evaluation of AMG 337, a Highly Selective Small Molecule MET Inhibitor, in Hepatocellular Carcinoma. Molecular Cancer Therapeutics. PMID 27196749 DOI: 10.1158/1535-7163.MCT-15-0745  0.088
1999 Hu LA, King SC. Identification of the amine-polyamine-choline transporter superfamily 'consensus amphipathic region' as the target for inactivation of the Escherichia coli GABA transporter GabP by thiol modification reagents. Role of Cys-300 in restoring thiol sensitivity to GabP lacking Cys Biochemical Journal. 339: 649-655. PMID 10215604 DOI: 10.1042/BJ3390649  0.074
1996 Brechtel CE, Hu L, King SC. Substrate specificity of the Escherichia coli 4-aminobutyrate carrier encoded by gabP. Uptake and counterflow of structurally diverse molecules. The Journal of Biological Chemistry. 271: 783-8. PMID 8557687 DOI: 10.1074/jbc.271.2.783  0.053
1999 HU LA, KING SC. Identification of the amine‒polyamine‒choline transporter superfamily ‘consensus amphipathic region’ as the target for inactivation of the Escherichia coli GABA transporter GabP by thiol modification reagents Biochemical Journal. 339: 649. DOI: 10.1042/0264-6021:3390649  0.037
1986 Ansari GAS, James GP, Hu LA, Reynolds ES. Organochlorine residues in adipose tissue of residents of the Texas Gulf coast Bulletin of Environmental Contamination and Toxicology. 36: 311-316. PMID 3081069 DOI: 10.1007/BF01623513  0.015
1982 Hu LA, Ansari GAS, Moslen MT, Reynolds ES. Efficient clean-up of fat samples by Sep-Pak cartridges for polybrominated biphenyl analysis Journal of Chromatography A. 241: 419-422. DOI: 10.1016/S0021-9673(00)81771-9  0.01
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