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Dean Staus - Publications

Affiliations: 
Duke University, Durham, NC 
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24 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2023 Skiba MA, Sterling SM, Rawson S, Gilman MSA, Xu H, Nemeth GR, Hurley JD, Shen P, Staus DP, Kim J, McMahon C, Lehtinen MK, Wingler LM, Kruse AC. Antibodies Expand the Scope of Angiotensin Receptor Pharmacology. Biorxiv : the Preprint Server For Biology. PMID 37662341 DOI: 10.1101/2023.08.23.554128  0.855
2021 Pani B, Ahn S, Rambarat PK, Vege S, Kahsai AW, Liu A, Valan BN, Staus DP, Costa T, Lefkowitz RJ. . Molecular Pharmacology. PMID 34580163 DOI: 10.1124/molpharm.121.000363  0.844
2021 Smith JS, Pack TF, Inoue A, Lee C, Zheng K, Choi I, Eiger DS, Warman A, Xiong X, Ma Z, Viswanathan G, Levitan IM, Rochelle LK, Staus DP, Snyder JC, et al. Noncanonical scaffolding of G and β-arrestin by G protein-coupled receptors. Science (New York, N.Y.). PMID 33479120 DOI: 10.1126/science.aay1833  0.819
2020 Pakharukova N, Masoudi A, Pani B, Staus DP, Lefkowitz RJ. Allosteric activation of proto-oncogene kinase Src by GPCR-beta-arrestin complexes. The Journal of Biological Chemistry. PMID 32978252 DOI: 10.1074/jbc.RA120.015400  0.844
2020 McMahon C, Staus DP, Wingler LM, Wang J, Skiba MA, Elgeti M, Hubbell WL, Rockman HA, Kruse AC, Lefkowitz RJ. Synthetic nanobodies as angiotensin receptor blockers. Proceedings of the National Academy of Sciences of the United States of America. PMID 32753386 DOI: 10.1073/Pnas.2009029117  0.848
2020 Wingler LM, Skiba MA, McMahon C, Staus DP, Kleinhenz ALW, Suomivuori CM, Latorraca NR, Dror RO, Lefkowitz RJ, Kruse AC. Angiotensin and biased analogs induce structurally distinct active conformations within a GPCR. Science (New York, N.Y.). 367: 888-892. PMID 32079768 DOI: 10.1126/Science.Aay9813  0.888
2020 Suomivuori CM, Latorraca NR, Wingler LM, Eismann S, King MC, Kleinhenz ALW, Skiba MA, Staus DP, Kruse AC, Lefkowitz RJ, Dror RO. Molecular mechanism of biased signaling in a prototypical G protein-coupled receptor. Science (New York, N.Y.). 367: 881-887. PMID 32079767 DOI: 10.1126/Science.Aaz0326  0.851
2020 Staus DP, Hu H, Robertson MJ, Kleinhenz ALW, Wingler LM, Capel WD, Latorraca NR, Lefkowitz RJ, Skiniotis G. Structure of the M2 muscarinic receptor-β-arrestin complex in a lipid nanodisc. Nature. PMID 31945772 DOI: 10.1038/S41586-020-1954-0  0.879
2020 McMahon C, Wingler L, Staus D, Lefkowitz R, Kruse A. So Long Llamas: Structure of Activated Angiotensin Receptor Stabilized by a Synthetic Nanobody The Faseb Journal. 34: 1-1. DOI: 10.1096/Fasebj.2020.34.S1.08990  0.829
2019 Staus DP, Wingler LM, Pichugin D, Prosser RS, Lefkowitz RJ. Detergent- and phospholipid-based reconstitution systems have differential effects on constitutive activity of G protein-coupled receptors. The Journal of Biological Chemistry. PMID 31362983 DOI: 10.1074/Jbc.Ac119.009848  0.862
2019 Liu X, Masoudi A, Kahsai AW, Huang LY, Pani B, Staus DP, Shim PJ, Hirata K, Simhal RK, Schwalb AM, Rambarat PK, Ahn S, Lefkowitz RJ, Kobilka B. Mechanism of βAR regulation by an intracellular positive allosteric modulator. Science (New York, N.Y.). 364: 1283-1287. PMID 31249059 DOI: 10.1126/science.aaw8981  0.866
2019 Wingler LM, McMahon C, Staus DP, Lefkowitz RJ, Kruse AC. Distinctive Activation Mechanism for Angiotensin Receptor Revealed by a Synthetic Nanobody. Cell. PMID 30639100 DOI: 10.1016/J.Cell.2018.12.006  0.887
2019 Wingler LM, Elgeti M, Hilger D, Latorraca NR, Lerch MT, Staus DP, Dror RO, Kobilka BK, Hubbell WL, Lefkowitz RJ. Angiotensin Analogs with Divergent Bias Stabilize Distinct Receptor Conformations. Cell. PMID 30639099 DOI: 10.1016/J.Cell.2018.12.005  0.888
2019 Liu X, Masoudi A, Kahsai AW, Huang L, Pani B, Staus DP, Shim PJ, Hirata K, Simhal RK, Schwalb AM, Rambarat PK, Ahn S, Lefkowitz RJ, Kobilka B. Mechanism of beta2AR regulation by an intracellular positive allosteric modulator. Science. 364: 1283-1287. DOI: 10.2210/Pdb6N48/Pdb  0.873
2018 Choi M, Staus DP, Wingler LM, Ahn S, Pani B, Capel WD, Lefkowitz RJ. G protein-coupled receptor kinases (GRKs) orchestrate biased agonism at the β-adrenergic receptor. Science Signaling. 11. PMID 30131371 DOI: 10.1126/Scisignal.Aar7084  0.837
2018 Ahn S, Pani B, Kahsai AW, Olsen EK, Husemoen G, Vestrgaard M, Jin L, Zhao S, Wingler LM, Rambarat PK, Simhal RK, Xu TT, Sun LD, Shim PJ, Staus DP, et al. Small Molecule Positive Allosteric Modulators of the β-Adrenoceptor Isolated from DNA Encoded Libraries. Molecular Pharmacology. PMID 29769246 DOI: 10.1124/Mol.118.111948  0.842
2018 Staus DP, Wingler LM, Choi M, Pani B, Manglik A, Kruse AC, Lefkowitz RJ. Sortase ligation enables homogeneous GPCR phosphorylation to reveal diversity in β-arrestin coupling. Proceedings of the National Academy of Sciences of the United States of America. PMID 29581292 DOI: 10.1073/Pnas.1722336115  0.859
2017 Wang J, Hanada K, Staus DP, Makara MA, Dahal GR, Chen Q, Ahles A, Engelhardt S, Rockman HA. Gαi is required for carvedilol-induced β1 adrenergic receptor β-arrestin biased signaling. Nature Communications. 8: 1706. PMID 29167435 DOI: 10.1038/S41467-017-01855-Z  0.665
2017 Paek J, Kalocsay M, Staus DP, Wingler L, Pascolutti R, Paulo JA, Gygi SP, Kruse AC. Multidimensional Tracking of GPCR Signaling via Peroxidase-Catalyzed Proximity Labeling. Cell. 169: 338-349.e11. PMID 28388415 DOI: 10.1016/J.Cell.2017.03.028  0.866
2017 Ahn S, Kahsai AW, Pani B, Wang QT, Zhao S, Wall AL, Strachan RT, Staus DP, Wingler LM, Sun LD, Sinnaeve J, Choi M, Cho T, Xu TT, Hansen GM, et al. Allosteric "beta-blocker" isolated from a DNA-encoded small molecule library. Proceedings of the National Academy of Sciences of the United States of America. PMID 28130548 DOI: 10.1073/Pnas.1620645114  0.828
2016 Staus DP, Strachan RT, Manglik A, Pani B, Kahsai AW, Kim TH, Wingler LM, Ahn S, Chatterjee A, Masoudi A, Kruse AC, Pardon E, Steyaert J, Weis WI, Prosser RS, et al. Allosteric nanobodies reveal the dynamic range and diverse mechanisms of G-protein-coupled receptor activation. Nature. PMID 27409812 DOI: 10.1038/Nature18636  0.835
2016 Kahsai AW, Wisler JW, Lee J, Ahn S, Cahill Iii TJ, Dennison SM, Staus DP, Thomsen AR, Anasti KM, Pani B, Wingler LM, Desai H, Bompiani KM, Strachan RT, Qin X, et al. Conformationally selective RNA aptamers allosterically modulate the β2-adrenoceptor. Nature Chemical Biology. PMID 27398998 DOI: 10.1038/Nchembio.2126  0.845
2014 Staus DP, Wingler LM, Strachan RT, Rasmussen SG, Pardon E, Ahn S, Steyaert J, Kobilka BK, Lefkowitz RJ. Regulation of β2-adrenergic receptor function by conformationally selective single-domain intrabodies. Molecular Pharmacology. 85: 472-81. PMID 24319111 DOI: 10.1124/Mol.113.089516  0.885
2013 Shukla AK, Manglik A, Kruse AC, Xiao K, Reis RI, Tseng WC, Staus DP, Hilger D, Uysal S, Huang LY, Paduch M, Tripathi-Shukla P, Koide A, Koide S, Weis WI, et al. Structure of active β-arrestin-1 bound to a G-protein-coupled receptor phosphopeptide. Nature. 497: 137-41. PMID 23604254 DOI: 10.1038/Nature12120  0.882
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