| Year |
Citation |
Score |
| 2017 |
Wobblish M, Carr R, Cowan C, Crombie A, Gowen-MacDonald W, Rominger D, Siuda E, Violin J, Lark M. (224) Assessment of Nociceptive Sensitization with TRV9101, a Novel μ Receptor G Protein Pathway Selective Modulator (μ-GPS), versus Fentanyl, Morphine, and Oxycodone The Journal of Pain. 18: S32. DOI: 10.1016/J.Jpain.2017.02.116 |
0.392 |
|
| 2016 |
Siuda ER, Carr R, Rominger DH, Violin JD. Biased mu-opioid receptor ligands: a promising new generation of pain therapeutics. Current Opinion in Pharmacology. 32: 77-84. PMID 27936408 DOI: 10.1016/J.Coph.2016.11.007 |
0.378 |
|
| 2015 |
Tarigopula M, Davis RT, Mungai PT, Ryba DM, Wieczorek DF, Cowan CL, Violin JD, Wolska BM, Solaro RJ. Cardiac myosin light chain phosphorylation and inotropic effects of a biased ligand, TRV120023, in a dilated cardiomyopathy model. Cardiovascular Research. 107: 226-34. PMID 26045475 DOI: 10.1093/Cvr/Cvv162 |
0.355 |
|
| 2015 |
Felker GM, Butler J, Collins SP, Cotter G, Davison BA, Ezekowitz JA, Filippatos G, Levy PD, Metra M, Ponikowski P, Soergel DG, Teerlink JR, Violin JD, Voors AA, Pang PS. Heart failure therapeutics on the basis of a biased ligand of the angiotensin-2 type 1 receptor. Rationale and design of the BLAST-AHF study (Biased Ligand of the Angiotensin Receptor Study in Acute Heart Failure). Jacc. Heart Failure. 3: 193-201. PMID 25650371 DOI: 10.1016/j.jchf.2014.09.008 |
0.362 |
|
| 2014 |
Violin JD, Crombie AL, Soergel DG, Lark MW. Biased ligands at G-protein-coupled receptors: Promise and progress Trends in Pharmacological Sciences. 35: 308-316. PMID 24878326 DOI: 10.1016/j.tips.2014.04.007 |
0.49 |
|
| 2014 |
Rominger DH, Cowan CL, Gowen-MacDonald W, Violin JD. Biased ligands: pathway validation for novel GPCR therapeutics. Current Opinion in Pharmacology. 16: 108-15. PMID 24834870 DOI: 10.1016/j.coph.2014.04.002 |
0.451 |
|
| 2014 |
Strachan RT, Sun JP, Rominger DH, Violin JD, Ahn S, Rojas Bie Thomsen A, Zhu X, Kleist A, Costa T, Lefkowitz RJ. Divergent transducer-specific molecular efficacies generate biased agonism at a G protein-coupled receptor (GPCR). The Journal of Biological Chemistry. 289: 14211-24. PMID 24668815 DOI: 10.1074/Jbc.M114.548131 |
0.79 |
|
| 2014 |
Violin JD, Crombie AL, Soergel DG, Lark MW. Biased ligands at G protein-coupled receptors: promise and progress. [Trends in Pharmacological Sciences 35 (2014) 308-316] (DOI:10.1016/j.tips.2014.04.007) Trends in Pharmacological Sciences. DOI: 10.1016/j.tips.2014.07.005 |
0.46 |
|
| 2013 |
Chen XT, Pitis P, Liu G, Yuan C, Gotchev D, Cowan CL, Rominger DH, Koblish M, Dewire SM, Crombie AL, Violin JD, Yamashita DS. Structure-activity relationships and discovery of a G protein biased μ opioid receptor ligand, [(3-methoxythiophen-2-yl)methyl]({2-[(9R)-9-(pyridin-2-yl)-6-oxaspiro-[4.5]decan-9-yl]ethyl})amine (TRV130), for the treatment of acute severe pain. Journal of Medicinal Chemistry. 56: 8019-31. PMID 24063433 DOI: 10.1021/Jm4010829 |
0.807 |
|
| 2013 |
Violin JD, Soergel DG, Boerrigter G, Burnett JC, Lark MW. GPCR biased ligands as novel heart failure therapeutics. Trends in Cardiovascular Medicine. 23: 242-9. PMID 23499300 DOI: 10.1016/j.tcm.2013.01.002 |
0.446 |
|
| 2013 |
DeWire SM, Yamashita DS, Rominger DH, Liu G, Cowan CL, Graczyk TM, Chen XT, Pitis PM, Gotchev D, Yuan C, Koblish M, Lark MW, Violin JD. A G protein-biased ligand at the μ-opioid receptor is potently analgesic with reduced gastrointestinal and respiratory dysfunction compared with morphine. The Journal of Pharmacology and Experimental Therapeutics. 344: 708-17. PMID 23300227 DOI: 10.1124/jpet.112.201616 |
0.801 |
|
| 2013 |
Violin J, DeWire S, Koblish M, Chen D, Crombie A, Yamashita D, Soergel D, Lark M. An orally available mu-opioid receptor biased ligand is analgesic with reduced constipation in rodents The Journal of Pain. 14: S70. DOI: 10.1016/j.jpain.2013.01.619 |
0.762 |
|
| 2012 |
Boerrigter G, Soergel DG, Violin JD, Lark MW, Burnett JC. TRV120027, a novel β-arrestin biased ligand at the angiotensin II type I receptor, unloads the heart and maintains renal function when added to furosemide in experimental heart failure. Circulation. Heart Failure. 5: 627-34. PMID 22891045 DOI: 10.1161/CIRCHEARTFAILURE.112.969220 |
0.393 |
|
| 2012 |
Heitzler D, Durand G, Gallay N, Rizk A, Ahn S, Kim J, Violin JD, Dupuy L, Gauthier C, Piketty V, Crépieux P, Poupon A, Clément F, Fages F, Lefkowitz RJ, et al. Competing G protein-coupled receptor kinases balance G protein and β-arrestin signaling. Molecular Systems Biology. 8: 590. PMID 22735336 DOI: 10.1038/Msb.2012.22 |
0.809 |
|
| 2012 |
Violin JD, Soergel DG, Lark MW. Beta-arrestin-biased ligands at the AT1R: A novel approach to the treatment of acute heart failure Drug Discovery Today: Therapeutic Strategies. 9. DOI: 10.1016/j.ddstr.2014.01.001 |
0.305 |
|
| 2011 |
Boerrigter G, Lark MW, Whalen EJ, Soergel DG, Violin JD, Burnett JC. Cardiorenal actions of TRV120027, a novel ß-arrestin-biased ligand at the angiotensin II type I receptor, in healthy and heart failure canines: a novel therapeutic strategy for acute heart failure. Circulation. Heart Failure. 4: 770-8. PMID 21835984 DOI: 10.1161/Circheartfailure.111.962571 |
0.754 |
|
| 2011 |
DeWire SM, Violin JD. Biased ligands for better cardiovascular drugs: dissecting G-protein-coupled receptor pharmacology. Circulation Research. 109: 205-16. PMID 21737816 DOI: 10.1161/CIRCRESAHA.110.231308 |
0.82 |
|
| 2011 |
Rajagopal S, Ahn S, Rominger DH, Gowen-MacDonald W, Lam CM, Dewire SM, Violin JD, Lefkowitz RJ. Quantifying ligand bias at seven-transmembrane receptors. Molecular Pharmacology. 80: 367-77. PMID 21610196 DOI: 10.1124/Mol.111.072801 |
0.818 |
|
| 2010 |
Violin JD, DeWire SM, Yamashita D, Rominger DH, Nguyen L, Schiller K, Whalen EJ, Gowen M, Lark MW. Selectively engaging β-arrestins at the angiotensin II type 1 receptor reduces blood pressure and increases cardiac performance. The Journal of Pharmacology and Experimental Therapeutics. 335: 572-9. PMID 20801892 DOI: 10.1124/Jpet.110.173005 |
0.825 |
|
| 2010 |
Violin JD, Soergel DG, DeWire SM, Yamashita D, Rominger D, Whalen EJ, Gowen M, Lark MW. TRV120027, a β-Arrestin Biased Ligand at the Angiotensin II Type 1 Receptor, Produces Unique Pharmacology and Is a Novel Potential Therapy for Heart Failure Journal of Cardiac Failure. 16: S72. DOI: 10.1016/j.cardfail.2010.06.247 |
0.766 |
|
| 2009 |
Tilley DG, Kim IM, Patel PA, Violin JD, Rockman HA. beta-Arrestin mediates beta1-adrenergic receptor-epidermal growth factor receptor interaction and downstream signaling. The Journal of Biological Chemistry. 284: 20375-86. PMID 19509284 DOI: 10.1074/Jbc.M109.005793 |
0.505 |
|
| 2009 |
Zidar DA, Violin JD, Whalen EJ, Lefkowitz RJ. Selective engagement of G protein coupled receptor kinases (GRKs) encodes distinct functions of biased ligands. Proceedings of the National Academy of Sciences of the United States of America. 106: 9649-54. PMID 19497875 DOI: 10.1073/Pnas.0904361106 |
0.841 |
|
| 2009 |
Walters RW, Shukla AK, Kovacs JJ, Violin JD, DeWire SM, Lam CM, Chen JR, Muehlbauer MJ, Whalen EJ, Lefkowitz RJ. beta-Arrestin1 mediates nicotinic acid-induced flushing, but not its antilipolytic effect, in mice. The Journal of Clinical Investigation. 119: 1312-21. PMID 19349687 DOI: 10.1172/Jci36806 |
0.773 |
|
| 2008 |
Kim IM, Tilley DG, Chen J, Salazar NC, Whalen EJ, Violin JD, Rockman HA. Beta-blockers alprenolol and carvedilol stimulate beta-arrestin-mediated EGFR transactivation. Proceedings of the National Academy of Sciences of the United States of America. 105: 14555-60. PMID 18787115 DOI: 10.1073/Pnas.0804745105 |
0.8 |
|
| 2008 |
Shukla AK, Violin JD, Whalen EJ, Gesty-Palmer D, Shenoy SK, Lefkowitz RJ. Distinct conformational changes in beta-arrestin report biased agonism at seven-transmembrane receptors. Proceedings of the National Academy of Sciences of the United States of America. 105: 9988-93. PMID 18621717 DOI: 10.1073/Pnas.0804246105 |
0.867 |
|
| 2008 |
Barak LS, Salahpour A, Zhang X, Masri B, Sotnikova TD, Ramsey AJ, Violin JD, Lefkowitz RJ, Caron MG, Gainetdinov RR. Pharmacological characterization of membrane-expressed human trace amine-associated receptor 1 (TAAR1) by a bioluminescence resonance energy transfer cAMP biosensor. Molecular Pharmacology. 74: 585-94. PMID 18524885 DOI: 10.1124/Mol.108.048884 |
0.644 |
|
| 2008 |
Drake MT, Violin JD, Whalen EJ, Wisler JW, Shenoy SK, Lefkowitz RJ. beta-arrestin-biased agonism at the beta2-adrenergic receptor. The Journal of Biological Chemistry. 283: 5669-76. PMID 18086673 DOI: 10.1074/Jbc.M708118200 |
0.857 |
|
| 2008 |
Violin JD, DiPilato LM, Yildirim N, Elston TC, Zhang J, Lefkowitz RJ. beta2-adrenergic receptor signaling and desensitization elucidated by quantitative modeling of real time cAMP dynamics. The Journal of Biological Chemistry. 283: 2949-61. PMID 18045878 DOI: 10.1074/Jbc.M707009200 |
0.72 |
|
| 2007 |
Wisler JW, DeWire SM, Whalen EJ, Violin JD, Drake MT, Ahn S, Shenoy SK, Lefkowitz RJ. A unique mechanism of beta-blocker action: carvedilol stimulates beta-arrestin signaling. Proceedings of the National Academy of Sciences of the United States of America. 104: 16657-62. PMID 17925438 DOI: 10.1073/Pnas.0707936104 |
0.828 |
|
| 2007 |
Noma T, Lemaire A, Naga Prasad SV, Barki-Harrington L, Tilley DG, Chen J, Le Corvoisier P, Violin JD, Wei H, Lefkowitz RJ, Rockman HA. Beta-arrestin-mediated beta1-adrenergic receptor transactivation of the EGFR confers cardioprotection. The Journal of Clinical Investigation. 117: 2445-58. PMID 17786238 DOI: 10.1172/Jci31901 |
0.805 |
|
| 2007 |
Violin JD, Lefkowitz RJ. Beta-arrestin-biased ligands at seven-transmembrane receptors. Trends in Pharmacological Sciences. 28: 416-22. PMID 17644195 DOI: 10.1016/j.tips.2007.06.006 |
0.672 |
|
| 2007 |
Whalen EJ, Foster MW, Matsumoto A, Ozawa K, Violin JD, Que LG, Nelson CD, Benhar M, Keys JR, Rockman HA, Koch WJ, Daaka Y, Lefkowitz RJ, Stamler JS. Regulation of beta-adrenergic receptor signaling by S-nitrosylation of G-protein-coupled receptor kinase 2. Cell. 129: 511-22. PMID 17482545 DOI: 10.1016/J.Cell.2007.02.046 |
0.842 |
|
| 2006 |
Rajagopal K, Whalen EJ, Violin JD, Stiber JA, Rosenberg PB, Premont RT, Coffman TM, Rockman HA, Lefkowitz RJ. Beta-arrestin2-mediated inotropic effects of the angiotensin II type 1A receptor in isolated cardiac myocytes. Proceedings of the National Academy of Sciences of the United States of America. 103: 16284-9. PMID 17060617 DOI: 10.1073/Pnas.0607583103 |
0.852 |
|
| 2006 |
Violin JD, Dewire SM, Barnes WG, Lefkowitz RJ. G protein-coupled receptor kinase and beta-arrestin-mediated desensitization of the angiotensin II type 1A receptor elucidated by diacylglycerol dynamics. The Journal of Biological Chemistry. 281: 36411-9. PMID 17008309 DOI: 10.1074/Jbc.M607956200 |
0.844 |
|
| 2006 |
Violin JD, Ren XR, Lefkowitz RJ. G-protein-coupled receptor kinase specificity for beta-arrestin recruitment to the beta2-adrenergic receptor revealed by fluorescence resonance energy transfer. The Journal of Biological Chemistry. 281: 20577-88. PMID 16687412 DOI: 10.1074/jbc.M513605200 |
0.846 |
|
| 2005 |
Hunton DL, Barnes WG, Kim J, Ren XR, Violin JD, Reiter E, Milligan G, Patel DD, Lefkowitz RJ. Beta-arrestin 2-dependent angiotensin II type 1A receptor-mediated pathway of chemotaxis. Molecular Pharmacology. 67: 1229-36. PMID 15635042 DOI: 10.1124/Mol.104.006270 |
0.825 |
|
| 2005 |
Barnes WG, Reiter E, Violin JD, Ren XR, Milligan G, Lefkowitz RJ. beta-Arrestin 1 and Galphaq/11 coordinately activate RhoA and stress fiber formation following receptor stimulation. The Journal of Biological Chemistry. 280: 8041-50. PMID 15611106 DOI: 10.1074/Jbc.M412924200 |
0.832 |
|
| 2000 |
Ostrom RS, Violin JD, Coleman S, Insel PA. Selective enhancement of beta-adrenergic receptor signaling by overexpression of adenylyl cyclase type 6: colocalization of receptor and adenylyl cyclase in caveolae of cardiac myocytes. Molecular Pharmacology. 57: 1075-9. PMID 10779394 |
0.525 |
|
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