Lewis T. Williams - Related publications

Affiliations: 
Duke University, Durham, NC 
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50 most relevant papers in past 60 days:
Year Citation  Score
2021 Mehr-Un-Nisa, Munawar MA, Rankin D, Hruby VJ, Porreca F, Lee YS. C-terminal modified Enkephalin-like tetrapeptides with enhanced affinities at the kappa opioid receptor and monoamine transporters. Bioorganic & Medicinal Chemistry. 51: 116509. PMID 34798381 DOI: 10.1016/j.bmc.2021.116509   
2021 Gao J, Yuan X, Zheng X, Zhao X, Wang T, Liang Q, Xiao C, Wang J, Li Q, Zhao X. Two-point immobilization of a conformation-specific beta-adrenoceptor for recognizing the receptor agonists or antagonists inspired by binding-induced DNA assembly. Biomaterials Science. PMID 34704989 DOI: 10.1039/d1bm01222c   
2021 Vidad AR, Macaspac S, Ng HL. Locating ligand binding sites in G-protein coupled receptors using combined information from docking and sequence conservation. Peerj. 9: e12219. PMID 34631323 DOI: 10.7717/peerj.12219   
2021 Khan SA, Zia K, Ashraf S, Khan A, Ul-Haq Z. Theoretical investigation of selective ligand binding mode of galanin receptors. Journal of Biomolecular Structure & Dynamics. 1-11. PMID 34632940 DOI: 10.1080/07391102.2021.1977703   
2021 Biswas AD, Catte A, Mancini G, Barone V. Analysis of L-DOPA and Droxidopa binding to Human β-Adrenergic Receptor. Biophysical Journal. PMID 34767786 DOI: 10.1016/j.bpj.2021.11.007   
2021 Wang M, Hou S, Liu Y, Li D, Lin J. Identification of Novel Antagonists Targeting Cannabinoid Receptor 2 Using a Multi-Step Virtual Screening Strategy. Molecules (Basel, Switzerland). 26. PMID 34771087 DOI: 10.3390/molecules26216679   
2021 Liu T, Yi TL, Yang DQ, Tao YX. Regulation of melanocortin-5 receptor pharmacology by two isoforms of MRAP2 in ricefield eel (Monopterus albus). General and Comparative Endocrinology. 113928. PMID 34653433 DOI: 10.1016/j.ygcen.2021.113928   
2021 Lee S. Development of High Affinity Calcitonin Analog Fragments Targeting Extracellular Domains of Calcitonin Family Receptors. Biomolecules. 11. PMID 34572577 DOI: 10.3390/biom11091364   
2021 Tan ZC, Meyer AS. A general model of multivalent binding with ligands of heterotypic subunits and multiple surface receptors. Mathematical Biosciences. 108714. PMID 34637774 DOI: 10.1016/j.mbs.2021.108714   
2021 Grimm LM, Sinn S, Krstić M, D'Este E, Sonntag I, Prasetyanto EA, Kuner T, Wenzel W, De Cola L, Biedermann F. Fluorescent Nanozeolite Receptors for the Highly Selective and Sensitive Detection of Neurotransmitters in Water and Biofluids. Advanced Materials (Deerfield Beach, Fla.). e2104614. PMID 34580934 DOI: 10.1002/adma.202104614   
2021 Sapkota K, Burnell ES, Irvine MW, Fang G, Gawande DY, Dravid SM, Jane DE, Monaghan DT. Pharmacological characterization of a novel negative allosteric modulator of NMDA receptors, UBP792. Neuropharmacology. 201: 108818. PMID 34610288 DOI: 10.1016/j.neuropharm.2021.108818   
2021 Sun S, Gu H, Cao L, Chen Q, Ye Q, Yang G, Li RT, Fan H, Deng YQ, Song X, Qi Y, Li M, Lan J, Feng R, Guo Y, et al. Characterization and structural basis of a lethal mouse-adapted SARS-CoV-2. Nature Communications. 12: 5654. PMID 34580297 DOI: 10.1038/s41467-021-25903-x   
2021 Buwaneka P, Ralko A, Gorai S, Pham H, Cho W. Phosphoinositide binding activity of Smad2 is essential for its function in TGF-β signaling. The Journal of Biological Chemistry. 101303. PMID 34655614 DOI: 10.1016/j.jbc.2021.101303   
2021 Heyder NA, Kleinau G, Speck D, Schmidt A, Paisdzior S, Szczepek M, Bauer B, Koch A, Gallandi M, Kwiatkowski D, Bürger J, Mielke T, Beck-Sickinger AG, Hildebrand PW, Spahn CMT, et al. Structures of active melanocortin-4 receptor-Gs-protein complexes with NDP-α-MSH and setmelanotide. Cell Research. PMID 34561620 DOI: 10.1038/s41422-021-00569-8   
2021 Zhang F, Chen X, Chen J, Xu Y, Li S, Guo Y, Pu X. Probing Allosteric Regulation Mechanism of W7.35 on Agonist-Induced Activity for μOR by Mutation Simulation. Journal of Chemical Information and Modeling. PMID 34779608 DOI: 10.1021/acs.jcim.1c00650   
2021 Arif R, Ahmad S, Mustafa G, Mahrosh HS, Ali M, Tahir Ul Qamar M, Dar HR. Molecular Docking and Simulation Studies of Antidiabetic Agents Devised from Hypoglycemic Polypeptide-P of . Biomed Research International. 2021: 5561129. PMID 34589547 DOI: 10.1155/2021/5561129   
2021 Patberg M, Isaak A, Füsser F, Ortiz Zacarías NV, Vinnenberg L, Schulte J, Michetti L, Grey L, van der Horst C, Hundehege P, Koch O, Heitman LH, Budde T, Junker A. Piperazine squaric acid diamides, a novel class of allosteric P2X7 receptor antagonists. European Journal of Medicinal Chemistry. 226: 113838. PMID 34571173 DOI: 10.1016/j.ejmech.2021.113838   
2021 Jørgensen AS, Brandum EP, Mikkelsen JM, Orfin KA, Boilesen DR, Egerod KL, Moussouras NA, Vilhardt F, Kalinski P, Basse P, Chen YH, Yang Z, Dwinell MB, Volkman BF, Veldkamp CT, et al. The C-terminal peptide of CCL21 drastically augments CCL21 activity through the dendritic cell lymph node homing receptor CCR7 by interaction with the receptor N-terminus. Cellular and Molecular Life Sciences : Cmls. PMID 34586443 DOI: 10.1007/s00018-021-03930-7   
2021 Gysel K, Laursen M, Thygesen MB, Lironi D, Bozsóki Z, Hjuler CT, Maolanon NN, Cheng J, Bjørk PK, Vinther M, Madsen LH, Rübsam H, Muszyński A, Ghodrati A, Azadi P, et al. Kinetic proofreading of lipochitooligosaccharides determines signal activation of symbiotic plant receptors. Proceedings of the National Academy of Sciences of the United States of America. 118. PMID 34716271 DOI: 10.1073/pnas.2111031118   
2021 Raïch I, Rivas-Santisteban R, Lillo A, Lillo J, Reyes-Resina I, Nadal X, Ferreiro-Vera C, de Medina VS, Majellaro M, Sotelo E, Navarro G, Franco R. Similarities and differences upon binding of naturally occurring Δ-tetrahydrocannabinol-derivatives to cannabinoid CB and CB receptors. Pharmacological Research. 174: 105970. PMID 34758399 DOI: 10.1016/j.phrs.2021.105970   
2021 Alwassil OI, Abdrakhmanova GR, Dukat M. Computational analysis of non-competitive antagonist arylguanidine-α7 nAChR complexes. Journal of Molecular Graphics & Modelling. 107: 107943. PMID 34058639 DOI: 10.1016/j.jmgm.2021.107943   
2021 Zhou Y, Zhou M, Qi Y, Wang W, Chen X, Wang S. The prognostic value of thyroid-stimulating immunoglobulin in the management of Graves' disease. Therapeutic Advances in Endocrinology and Metabolism. 12: 20420188211044943. PMID 34603682 DOI: 10.1177/20420188211044943   
2021 Wines BD, Trist HM, Esparon S, Impey RE, Mackay GA, Andrews RK, Soares da Costa TP, Pietersz GA, Baker RI, Hogarth PM. Fc Binding by FcγRIIa Is Essential for Cellular Activation by the Anti-FcγRIIa mAbs 8.26 and 8.2. Frontiers in Immunology. 12: 666813. PMID 34759915 DOI: 10.3389/fimmu.2021.666813   
2021 Raj S, Lu L, Unsworth LD. Screening Peptides that Activate MRGPRX2 using Engineered HEK Cells. Journal of Visualized Experiments : Jove. PMID 34806705 DOI: 10.3791/62448   
2021 Shi F, Mendrola JM, Sheetz JB, Wu N, Sommer A, Speer KF, Noordermeer JN, Kan ZY, Perry K, Englander SW, Stayrook SE, Fradkin LG, Lemmon MA. ROR and RYK extracellular region structures suggest that receptor tyrosine kinases have distinct WNT-recognition modes. Cell Reports. 37: 109834. PMID 34686333 DOI: 10.1016/j.celrep.2021.109834   
2021 Howlett AC, Thomas BF, Huffman JW. The Spicy Story of Cannabimimetic Indoles. Molecules (Basel, Switzerland). 26. PMID 34684770 DOI: 10.3390/molecules26206190   
2021 Long S, Ji S, Xiao K, Xue P, Zhu S. Prognostic and immunological value of LTB4R in pan-cancer. Mathematical Biosciences and Engineering : Mbe. 18: 9336-9356. PMID 34814348 DOI: 10.3934/mbe.2021459   
2021 Song Y, Deng X, Shi W, Tang F, Huang W, Gong L, Qin Q. A homogeneous time-resolved fluorometric energy transfer assay for the binding assessment of FcRn with IgG antibodies. Journal of Immunological Methods. 113180. PMID 34736962 DOI: 10.1016/j.jim.2021.113180   
2021 Tsuzuki S, Kimoto Y, Yamasaki M, Sugawara T, Manabe Y, Inoue K, Sasaki T. Assessment of direct binding interaction between CD36 and its potential lipid ligands using a peptide mimic of the receptor labeled with a fluorophore. Biomedical Research (Tokyo, Japan). 42: 181-191. PMID 34544994 DOI: 10.2220/biomedres.42.181   
2021 Jagleniec D, Walczak N, Dobrzycki Ł, Romański J. Utilizing an Amino Acid Scaffold to Construct Heteroditopic Receptors Capable of Interacting with Salts under Interfacial Conditions. International Journal of Molecular Sciences. 22. PMID 34639095 DOI: 10.3390/ijms221910754   
2021 Jenkins L, Marsango S, Mancini S, Mahmud ZA, Morrison A, McElroy SP, Bennett KA, Barnes M, Tobin AB, Tikhonova IG, Milligan G. Discovery and Characterization of Novel Antagonists of the Proinflammatory Orphan Receptor GPR84. Acs Pharmacology & Translational Science. 4: 1598-1613. PMID 34661077 DOI: 10.1021/acsptsci.1c00151   
2021 Bolt MJ, Singh P, Obkirchner CE, Powell RT, Mancini MG, Szafran AT, Stossi F, Mancini MA. Endocrine disrupting chemicals differentially alter intranuclear dynamics and transcriptional activation of estrogen receptor-α. Iscience. 24: 103227. PMID 34712924 DOI: 10.1016/j.isci.2021.103227   
2021 Sprague DJ, Getschman AE, Fenske TG, Volkman BF, Smith BC. Trisubstituted 1,3,5-Triazines: The First Ligands of the sY12-Binding Pocket on Chemokine CXCL12. Acs Medicinal Chemistry Letters. 12: 1773-1782. PMID 34795867 DOI: 10.1021/acsmedchemlett.1c00388   
2021 Rečnik LM, Thatcher RJ, Mallah S, Butts CP, Collingridge GL, Molnár E, Jane DE, Willis CL. Synthesis and pharmacological characterisation of arctigenin analogues as antagonists of AMPA and kainate receptors. Organic & Biomolecular Chemistry. 19: 9154-9162. PMID 34642722 DOI: 10.1039/d1ob01653a   
2021 Okita K, Kato K, Shigemoto Y, Sato N, Matsumoto T, Matsuda H. Effects of an Adenosine A Receptor Antagonist on Striatal Dopamine D2-Type Receptor Availability: A Randomized Control Study Using Positron Emission Tomography. Frontiers in Neuroscience. 15: 729153. PMID 34588952 DOI: 10.3389/fnins.2021.729153   
2021 Fu W, Zhang M, Liao J, Tang Q, Lei Y, Gong Z, Shan L, Duan M, Chai X, Pang J, Tang C, Wang X, Xu X, Li D, Sheng R, et al. Discovery of a Novel Androgen Receptor Antagonist Manifesting Evidence to Disrupt the Dimerization of the Ligand-Binding Domain via Attenuating the Hydrogen-Bonding Network Between the Two Monomers. Journal of Medicinal Chemistry. PMID 34809430 DOI: 10.1021/acs.jmedchem.1c01287   
2021 Fierro A, Matthies DJ, Cassels BK, Jaque P, Zapata-Torres G. 5-HT Receptor Subfamily and the Halogen Bond Promise. Journal of Chemical Information and Modeling. 61: 5001-5012. PMID 34617740 DOI: 10.1021/acs.jcim.1c00466   
2021 Hong J, Kwon HJ, Cachau R, Chen CZ, Butay KJ, Duan Z, Li D, Ren H, Liang T, Zhu J, Dandey VP, Martin N, Esposito D, Ortega-Rodriguez U, Xu M, et al. Camel nanobodies broadly neutralize SARS-CoV-2 variants. Biorxiv : the Preprint Server For Biology. PMID 34751270 DOI: 10.1101/2021.10.27.465996   
2021 Bachurin SO, Makhaeva GF, Shevtsova EF, Aksinenko AY, Grigoriev VV, Shevtsov PN, Goreva TV, Epishina TA, Kovaleva NV, Pushkareva EA, Boltneva NP, Lushchekina SV, Gabrelyan AV, Zamoyski VL, Dubova LG, et al. Conjugation of Aminoadamantane and γ-Carboline Pharmacophores Gives Rise to Unexpected Properties of Multifunctional Ligands. Molecules (Basel, Switzerland). 26. PMID 34576998 DOI: 10.3390/molecules26185527   
2021 Li T, Cai H, Zhao Y, Li Y, Lai Y, Yao H, Liu LD, Sun Z, van Vlissingen MF, Kuiken T, GeurtsvanKessel CH, Zhang N, Zhou B, Lu L, Gong Y, et al. Uncovering a conserved vulnerability site in SARS-CoV-2 by a human antibody. Embo Molecular Medicine. e14544. PMID 34672091 DOI: 10.15252/emmm.202114544   
2021 Mitra A, Sarkar A, Borics A. Universal Properties and Specificities of the β-Adrenergic Receptor-G Protein Complex Activation Mechanism Revealed by All-Atom Molecular Dynamics Simulations. International Journal of Molecular Sciences. 22. PMID 34638767 DOI: 10.3390/ijms221910423   
2021 Asai D, Inoue N, Sugiyama M, Fujita T, Matsuyama Y, Liu X, Matsushima A, Nose T, Costa T, Shimohigashi Y. Direct evidence of edge-to-face CH/π interaction for PAR-1 thrombin receptor activation. Bioorganic & Medicinal Chemistry. 51: 116498. PMID 34794000 DOI: 10.1016/j.bmc.2021.116498   
2021 Levick SP. Histamine receptors in heart failure. Heart Failure Reviews. PMID 34622365 DOI: 10.1007/s10741-021-10166-x   
2021 Denys IB, Gao J, Sutphen JC, Zaveri NT, Kapusta DR. Cardiovascular and renal effects of novel non-peptide nociceptin opioid peptide (NOP) receptor agonists. British Journal of Pharmacology. PMID 34705263 DOI: 10.1111/bph.15717   
2021 Wookey P, Gupta P, Bittencourt L, Cheung S, Hare D, Furness S. Methods to measure calcitonin receptor activity, up-regulated in cell stress, apoptosis and autophagy. F1000research. 10: 1019. PMID 34745567 DOI: 10.12688/f1000research.72845.1   
2021 Nagarajan SK, Babu S, Devaraju P, Sohn H, Madhavan T. Structure and dynamics of the Somatostatin receptor 3 (SSTR3)-ligand binding in presence of lipids examined using computational structural biology methods. Proteins. PMID 34661304 DOI: 10.1002/prot.26267   
2021 Yan W, Fan L, Yu J, Liu R, Wang H, Tan L, Wang S, Cheng J. 2-Phenylcyclopropylmethylamine Derivatives as Dopamine D Receptor Partial Agonists: Design, Synthesis, and Biological Evaluation. Journal of Medicinal Chemistry. PMID 34797051 DOI: 10.1021/acs.jmedchem.1c01327   
2021 Ishida A, Okabe Y, Matsushita T, Sekiguchi T, Nishio T, Komagata T, Iwaki M, Miyata H, Katagi J, Naganawa A, Maruyama T, Imagawa A. Design, synthesis, and biological evaluation of novel somatostatin receptor subtype-2 agonists: Optimization for potency and risk mitigation of hERG and phospholipidosis. Bioorganic & Medicinal Chemistry. 49: 116424. PMID 34626901 DOI: 10.1016/j.bmc.2021.116424   
2021 Steindorf D, Loeuillet A, Bagnard D, Strand S, Schneider D. Increased stability of the TM helix oligomer abrogates the apoptotic activity of the human Fas receptor. Biochimica Et Biophysica Acta. Biomembranes. 1864: 183807. PMID 34662567 DOI: 10.1016/j.bbamem.2021.183807   
2021 Kang S, Kim NH, Yu YG. Identification of novel positive allosteric modulators of GLP1R that stimulate its interaction with ligands and G subunits. Biochemical and Biophysical Research Communications. 583: 162-168. PMID 34739856 DOI: 10.1016/j.bbrc.2021.10.071