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Graciela Pineyro - Publications

Affiliations: 
Biochemistry and Molecular Medicine Université de Montréal, Montréal, Canada 
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32 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2021 Mansour A, Nagi K, Dallaire P, Lukasheva V, Le Gouill C, Bouvier M, Pineyro G. Comprehensive Signaling Profiles Reveal Unsuspected Functional Selectivity of δ-Opioid Receptor Agonists and Allow the Identification of Ligands with the Greatest Potential for Inducing Cyclase Superactivation. Acs Pharmacology & Translational Science. 4: 1483-1498. PMID 34661070 DOI: 10.1021/acsptsci.1c00019  0.632
2020 Pineyro G, Nagi K. Signaling diversity of mu- and delta- opioid receptor ligands: Re-evaluating the benefits of β-arrestin/G protein signaling bias. Cellular Signalling. 109906. PMID 33383156 DOI: 10.1016/j.cellsig.2020.109906  0.456
2020 Lukasheva V, Devost D, Le Gouill C, Namkung Y, Martin RD, Longpré JM, Amraei M, Shinjo Y, Hogue M, Lagacé M, Breton B, Aoki J, Tanny JC, Laporte SA, Pineyro G, et al. Signal profiling of the βAR reveals coupling to novel signalling pathways and distinct phenotypic responses mediated by βAR and βAR. Scientific Reports. 10: 8779. PMID 32471984 DOI: 10.1038/S41598-020-65636-3  0.734
2020 Benredjem B, Gallion J, Pelletier D, Dallaire P, Charbonneau J, Cawkill D, Nagi K, Gosink M, Lukasheva V, Jenkinson S, Ren Y, Somps C, Murat B, Van Der Westhuizen E, Le Gouill C, ... ... Pineyro G, et al. Author Correction: Exploring use of unsupervised clustering to associate signaling profiles of GPCR ligands to clinical response. Nature Communications. 11: 1929. PMID 32300106 DOI: 10.1038/S41467-020-15945-Y  0.642
2020 Bagheri Tudashki H, Haddad Y, Charfi I, Couture R, Pineyro G. Ligand-specific recycling profiles determine distinct potential for chronic analgesic tolerance of delta-opioid receptor (DOPr) agonists. Journal of Cellular and Molecular Medicine. PMID 32279433 DOI: 10.1111/Jcmm.15234  0.425
2019 Benredjem B, Gallion J, Pelletier D, Dallaire P, Charbonneau J, Cawkill D, Nagi K, Gosink M, Lukasheva V, Jenkinson S, Ren Y, Somps C, Murat B, Van Der Westhuizen E, Le Gouill C, ... ... Pineyro G, et al. Exploring use of unsupervised clustering to associate signaling profiles of GPCR ligands to clinical response. Nature Communications. 10: 4075. PMID 31501422 DOI: 10.1038/S41467-019-11875-6  0.668
2019 Gendron L, Nagi K, Zeghal M, Giguère PM, Pineyro G. Molecular aspects of delta opioid receptors. Vitamins and Hormones. 111: 49-90. PMID 31421707 DOI: 10.1016/Bs.Vh.2019.06.001  0.452
2019 Jean-Louis B, Blais VD, Holleran BJ, Bergeron A, Pineyro G, Guérin B, Gendron L, Dory YL. N-guanidyl and C-tetrazole Leu-Enkephalin Derivatives: Efficient Mu and Delta Opioid Receptor Agonists with Improved Pharmacological Properties. Acs Chemical Neuroscience. PMID 30614675 DOI: 10.1021/Acschemneuro.8B00550  0.369
2018 Namkung Y, LeGouill C, Kumar S, Cao Y, Teixeira LB, Lukasheva V, Giubilaro J, Simões SC, Longpré JM, Devost D, Hébert TE, Piñeyro G, Leduc R, Costa-Neto CM, Bouvier M, et al. Functional selectivity profiling of the angiotensin II type 1 receptor using pathway-wide BRET signaling sensors. Science Signaling. 11. PMID 30514808 DOI: 10.1126/Scisignal.Aat1631  0.692
2018 Bella Ndong D, Blais V, Holleran BJ, Proteau-Gagné A, Cantin-Savoie I, Robert W, Nadon J, Beauchemin S, Leduc R, Piñeyro G, Guérin B, Gendron L, Dory YL. Exploration of the fifth position of leu-enkephalin and its role in binding and activating delta (DOP) and mu (MOP) opioid receptors Peptide Science. 111: e24070. DOI: 10.1002/Pep2.24070  0.373
2017 Charfi I, Abdallah K, Gendron L, Pineyro G. Delta opioid receptors recycle to the membrane after sorting to the degradation path. Cellular and Molecular Life Sciences : Cmls. PMID 29288293 DOI: 10.1007/S00018-017-2732-5  0.424
2016 Benredjem B, Dallaire P, Pineyro G. Analyzing biased responses of GPCR ligands. Current Opinion in Pharmacology. 32: 71-76. PMID 27930943 DOI: 10.1016/J.Coph.2016.11.008  0.634
2016 Gendron L, Cahill CM, von Zastrow M, Schiller PW, Pineyro G. Molecular Pharmacology of δ-Opioid Receptors. Pharmacological Reviews. 68: 631-700. PMID 27343248 DOI: 10.1124/Pr.114.008979  0.432
2016 Nagi K, Pineyro G. Practical guide for calculating and representing biased signaling by GPCR ligands: A stepwise approach. Methods (San Diego, Calif.). 92: 78-86. PMID 26364590 DOI: 10.1016/J.Ymeth.2015.09.010  0.608
2015 Robertson DN, Sleno R, Nagi K, Pétrin D, Hébert TE, Pineyro G. Design and construction of conformational biosensors to monitor ion channel activation: A prototype FlAsH/BRET-approach to Kir3 channels. Methods (San Diego, Calif.). PMID 26210401 DOI: 10.1016/J.Ymeth.2015.07.011  0.319
2015 Nagi K, Charfi I, Pineyro G. Kir3 channels undergo arrestin-dependant internalization following delta opioid receptor activation. Cellular and Molecular Life Sciences : Cmls. 72: 3543-57. PMID 25900661 DOI: 10.1007/S00018-015-1899-X  0.41
2015 Charfi I, Audet N, Tudashki HB, Pineyro G. Identifying ligand-specific signalling within biased responses: focus on δ opioid receptor ligands British Journal of Pharmacology. 172: 435-448. PMID 24665881 DOI: 10.1111/Bph.12705  0.553
2014 Nagi K, Pineyro G. Kir3 channel signaling complexes: focus on opioid receptor signaling. Frontiers in Cellular Neuroscience. 8: 186. PMID 25071446 DOI: 10.3389/Fncel.2014.00186  0.49
2014 Bourassa P, Tudashki HB, Pineyro G, Grandbois M, Gendron L. Label-free monitoring of μ-opioid receptor-mediated signaling. Molecular Pharmacology. 86: 138-49. PMID 24874699 DOI: 10.1124/Mol.114.093450  0.482
2014 Tudashki HB, Robertson DN, Schiller PW, Pineyro G. Endocytic profiles of δ-opioid receptor ligands determine the duration of rapid but not sustained cAMP responses. Molecular Pharmacology. 85: 148-61. PMID 24174495 DOI: 10.1124/Mol.113.089003  0.531
2014 Charfi I, Nagi K, Mnie-Filali O, Thibault D, Balboni G, Schiller PW, Trudeau LE, Pineyro G. Ligand- and cell-dependent determinants of internalization and cAMP modulation by delta opioid receptor (DOR) agonists Cellular and Molecular Life Sciences. 71: 1529-1546. PMID 24022593 DOI: 10.1007/S00018-013-1461-7  0.509
2013 Richard-Lalonde M, Nagi K, Audet N, Sleno R, Amraei M, Hogue M, Balboni G, Schiller PW, Bouvier M, Hébert TE, Pineyro G. Conformational dynamics of Kir3.1/Kir3.2 channel activation via δ-opioid receptors. Molecular Pharmacology. 83: 416-28. PMID 23175530 DOI: 10.1124/Mol.112.081950  0.554
2012 Audet N, Charfi I, Mnie-Filali O, Amraei M, Chabot-Doré AJ, Millecamps M, Stone LS, Pineyro G. Differential association of receptor-Gβγ complexes with β-arrestin2 determines recycling bias and potential for tolerance of δ opioid receptor agonists. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 32: 4827-40. PMID 22492038 DOI: 10.1523/Jneurosci.3734-11.2012  0.49
2011 Audet N, Piñeyro G. Using BRET to detect ligand-specific conformational changes in preformed signalling complexes. Methods in Molecular Biology (Clifton, N.J.). 756: 149-63. PMID 21870224 DOI: 10.1007/978-1-61779-160-4_7  0.549
2011 Nagi K, Piñeyro G. Regulation of opioid receptor signalling: implications for the development of analgesic tolerance. Molecular Brain. 4: 25. PMID 21663702 DOI: 10.1186/1756-6606-4-25  0.447
2011 Thibault D, Albert PR, Pineyro G, Trudeau LÉ. Neurotensin triggers dopamine D2 receptor desensitization through a protein kinase C and beta-arrestin1-dependent mechanism. The Journal of Biological Chemistry. 286: 9174-84. PMID 21233215 DOI: 10.1074/Jbc.M110.166454  0.331
2010 Lucas G, Du J, Romeas T, Mnie-Filali O, Haddjeri N, Piñeyro G, Debonnel G. Selective serotonin reuptake inhibitors potentiate the rapid antidepressant-like effects of serotonin4 receptor agonists in the rat. Plos One. 5: e9253. PMID 20169084 DOI: 10.1371/Journal.Pone.0009253  0.327
2009 Piñeyro G. Membrane signalling complexes: implications for development of functionally selective ligands modulating heptahelical receptor signalling. Cellular Signalling. 21: 179-85. PMID 18790047 DOI: 10.1016/J.Cellsig.2008.08.013  0.613
2009 Archer-Lahlou E, Audet N, Amraei MG, Huard K, Paquin-Gobeil M, Pineyro G. Src promotes delta opioid receptor (DOR) desensitization by interfering with receptor recycling. Journal of Cellular and Molecular Medicine. 13: 147-63. PMID 18363847 DOI: 10.1111/J.1582-4934.2008.00308.X  0.462
2008 Audet N, Galés C, Archer-Lahlou E, Vallières M, Schiller PW, Bouvier M, Pineyro G. Bioluminescence resonance energy transfer assays reveal ligand-specific conformational changes within preformed signaling complexes containing delta-opioid receptors and heterotrimeric G proteins. The Journal of Biological Chemistry. 283: 15078-88. PMID 18381293 DOI: 10.1074/Jbc.M707941200  0.655
2007 Piñeyro G, Archer-Lahlou E. Ligand-specific receptor states: implications for opiate receptor signalling and regulation. Cellular Signalling. 19: 8-19. PMID 16842969 DOI: 10.1016/J.Cellsig.2006.05.026  0.58
2005 Audet N, Paquin-Gobeil M, Landry-Paquet O, Schiller PW, Piñeyro G. Internalization and Src activity regulate the time course of ERK activation by delta opioid receptor ligands. The Journal of Biological Chemistry. 280: 7808-16. PMID 15632168 DOI: 10.1074/Jbc.M411695200  0.497
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