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Michael Rynkiewicz - Publications

Affiliations: 
2015- Physiology & Biophysics Boston University, Boston, MA, United States 
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43 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2024 Barry ME, Rynkiewicz MJ, Pavadai E, Viana A, Lehman W, Moore JR. Glutamate 139 of tropomyosin is critical for cardiac thin filament blocked-state stabilization. Journal of Molecular and Cellular Cardiology. PMID 38266978 DOI: 10.1016/j.yjmcc.2024.01.004  0.653
2023 Lehman W, Rynkiewicz MJ. Troponin-I-induced tropomyosin pivoting defines thin-filament function in relaxed and active muscle. The Journal of General Physiology. 155. PMID 37249525 DOI: 10.1085/jgp.202313387  0.622
2023 Halder SS, Rynkiewicz MJ, Creso JG, Sewanan LR, Howland L, Moore JR, Lehman W, Campbell SG. Mechanisms of pathogenicity in the hypertrophic cardiomyopathy-associated TPM1 variant S215L. Pnas Nexus. 2: pgad011. PMID 36896133 DOI: 10.1093/pnasnexus/pgad011  0.6
2023 Doran MH, Rynkiewicz MJ, Rassici D, Bodt SML, Barry ME, Bullitt E, Yengo CM, Moore JR, Lehman W. Conformational changes linked to ADP release from human cardiac myosin bound to actin-tropomyosin. The Journal of General Physiology. 155. PMID 36633586 DOI: 10.1085/jgp.202213267  0.573
2022 Doran MH, Rynkiewicz MJ, Pavadai E, Bodt SML, Rasicci D, Moore JR, Yengo CM, Bullitt E, Lehman W. Myosin loop-4 is critical for optimal tropomyosin repositioning on actin during muscle activation and relaxation. The Journal of General Physiology. 155. PMID 36459134 DOI: 10.1085/jgp.202213274  0.626
2022 Rynkiewicz MJ, Pavadai E, Lehman W. Modeling Human Cardiac Thin Filament Structures. Frontiers in Physiology. 13: 932333. PMID 35812320 DOI: 10.3389/fphys.2022.932333  0.606
2022 Pavadai E, Rynkiewicz MJ, Yang Z, Gould IR, Marston SB, Lehman W. Modulation of cardiac thin filament structure by phosphorylated troponin-I analyzed by protein-protein docking and molecular dynamics simulation. Archives of Biochemistry and Biophysics. 725: 109282. PMID 35577070 DOI: 10.1016/j.abb.2022.109282  0.62
2022 Teekakirikul P, Zhu W, Xu X, Young CB, Tan T, Smith AM, Wang C, Peterson KA, Gabriel GC, Ho S, Sheng Y, Moreau de Bellaing A, Sonnenberg DA, Lin JH, Fotiou E, ... ... Rynkiewicz MJ, et al. Genetic resiliency associated with dominant lethal mutation causing atrial septal defect with high heritability. Cell Reports. Medicine. 3: 100501. PMID 35243414 DOI: 10.1016/j.xcrm.2021.100501  0.551
2021 Sewanan LR, Park J, Rynkiewicz MJ, Racca AW, Papoutsidakis N, Schwan J, Jacoby DL, Moore JR, Lehman W, Qyang Y, Campbell SG. Loss of crossbridge inhibition drives pathological cardiac hypertrophy in patients harboring the TPM1 E192K mutation. The Journal of General Physiology. 153. PMID 34319370 DOI: 10.1085/jgp.202012640  0.585
2021 Lehman W, Pavadai E, Rynkiewicz MJ. C-terminal troponin-I residues trap tropomyosin in the muscle thin filament blocked-state. Biochemical and Biophysical Research Communications. 551: 27-32. PMID 33714756 DOI: 10.1016/j.bbrc.2021.03.010  0.597
2020 Racca AW, Rynkiewicz MJ, LaFave N, Ghosh A, Lehman W, Moore JR. M8R tropomyosin mutation disrupts actin-binding and filament regulation: the beginning affects the middle and end. The Journal of Biological Chemistry. PMID 33020181 DOI: 10.1074/jbc.RA120.014713  0.674
2020 Doran MH, Pavadai E, Rynkiewicz MJ, Walklate J, Bullitt E, Moore JR, Regnier M, Geeves MA, Lehman W. Cryo-EM and Molecular Docking Shows Myosin Loop 4 Contacts Actin and Tropomyosin on Thin Filaments. Biophysical Journal. PMID 32730789 DOI: 10.1016/J.Bpj.2020.07.006  0.656
2020 Pavadai E, Lehman W, Rynkiewicz MJ. Protein-Protein Docking Reveals Dynamic Interactions of Tropomyosin on Actin Filaments. Biophysical Journal. 119: 75-86. PMID 32521240 DOI: 10.1016/J.Bpj.2020.05.017  0.635
2020 Viswanathan MC, Schmidt W, Franz P, Rynkiewicz MJ, Newhard CS, Madan A, Lehman W, Swank DM, Preller M, Cammarato A. A role for actin flexibility in thin filament-mediated contractile regulation and myopathy. Nature Communications. 11: 2417. PMID 32415060 DOI: 10.1038/S41467-020-15922-5  0.649
2020 Pavadai E, Rynkiewicz MJ, Lehman W. A Tropomyosin Cable Model on Thin-Filaments Deduced by Protein-Protein Docking Biophysical Journal. 118. DOI: 10.1016/J.Bpj.2019.11.3205  0.482
2020 Rynkiewicz MJ, Lehman W. Molecular Dynamics Simulations of Alpha-Beta-Tropomyosin Show Conformational Properties of Heterodimeric Tropomyosin Biophysical Journal. 118. DOI: 10.1016/J.Bpj.2019.11.1598  0.477
2019 Sundar S, Rynkiewicz MJ, Ghosh A, Lehman W, Moore JR. Cardiomyopathy Mutation Alters End-to-End Junction of Tropomyosin and Reduces Calcium Sensitivity. Biophysical Journal. PMID 31882250 DOI: 10.1016/J.Bpj.2019.11.3396  0.67
2019 Pavadai E, Rynkiewicz MJ, Ghosh A, Lehman W. Docking Troponin T onto the Tropomyosin Overlapping Domain of Thin Filaments. Biophysical Journal. PMID 31864661 DOI: 10.1016/J.Bpj.2019.11.3393  0.639
2019 Janco M, Rynkiewicz MJ, Li L, Hook J, Eiffe E, Ghosh A, Böcking T, Lehman WJ, Hardeman EC, Gunning PW. Molecular integration of the anti-tropomyosin compound ATM-3507 into the coiled coil overlap region of the cancer-associated Tpm3.1. Scientific Reports. 9: 11262. PMID 31375704 DOI: 10.1038/S41598-019-47592-9  0.613
2019 Lehman W, Moore JR, Campbell SG, Rynkiewicz MJ. The Effect of Tropomyosin Mutations on Actin-Tropomyosin Binding: In Search of Lost Time. Biophysical Journal. PMID 31130236 DOI: 10.1016/J.Bpj.2019.05.009  0.668
2019 Lehman W, Rynkiewicz MJ, Moore JR. A new twist on tropomyosin binding to actin filaments: perspectives on thin filament function, assembly and biomechanics. Journal of Muscle Research and Cell Motility. PMID 30771202 DOI: 10.1007/S10974-019-09501-5  0.646
2019 Racca AW, LaFave N, Jones S, Rynkiewicz MJ, Lehman W, Moore JR. Functional Implications of Dcm End-to-End Bond Mutation in A-Tropomyosin Biophysical Journal. 116. DOI: 10.1016/J.Bpj.2018.11.989  0.488
2019 Rynkiewicz MJ, Moore JR, Campbell SG, Lehman W. A New Twist on the Mechanism of Mutation-Induced Tropomyosin Dysfunction Biophysical Journal. 116: 552a. DOI: 10.1016/J.Bpj.2018.11.2966  0.51
2019 Sundar S, Rynkiewicz MJ, Lehman W, Moore JR. Cardiomyopathy Mutation at End-End Overlap of Alpha - Tropomyosin Influences Cooperative Activation and Calcium Sensitivity Biophysical Journal. 116. DOI: 10.1016/J.Bpj.2018.11.2517  0.506
2019 Kiani FA, Lehman W, Fischer S, Rynkiewicz MJ. Tropomyosin Cable Formation and Its Influence on the Structural Dynamics of Tropomyosin Biophysical Journal. 116. DOI: 10.1016/J.Bpj.2018.11.199  0.504
2019 Ghosh A, Janco M, Böcking T, Gunning PW, Lehman W, Rynkiewicz MJ. Structure of the Tpm3.1 N-Terminus: A New Target for Anti-Cancer Treatment Biophysical Journal. 116: 253a-254a. DOI: 10.1016/J.Bpj.2018.11.1382  0.429
2018 Kiani FA, Lehman W, Fischer S, Rynkiewicz MJ. Spontaneous transitions of actin-bound tropomyosin toward blocked and closed states. The Journal of General Physiology. PMID 30442774 DOI: 10.1085/Jgp.201812188  0.618
2018 Lehman W, Li X, Kiani FA, Moore JR, Campbell SG, Fischer S, Rynkiewicz MJ. Precise Binding of Tropomyosin on Actin Involves Sequence-Dependent Variance in Coiled-Coil Twisting. Biophysical Journal. PMID 30195938 DOI: 10.1016/J.Bpj.2018.08.017  0.623
2018 Farman GP, Rynkiewicz MJ, Orzechowski M, Lehman W, Moore JR. HCM and DCM cardiomyopathy-linked α-tropomyosin mutations influence off-state stability and crossbridge interaction on thin filaments. Archives of Biochemistry and Biophysics. PMID 29626422 DOI: 10.1016/J.Abb.2018.04.002  0.645
2018 Kiani FA, Rynkiewicz MJ, Fischer S, Lehman W. Tropomyosin Translocation on F-Actin Revealed by Molecular Dynamics Simulations Biophysical Journal. 114. DOI: 10.1016/J.Bpj.2017.11.769  0.56
2018 Sewanan LR, Park J, Rynkiewicz MJ, Hollenberg SM, Papoutsidakis N, Jacoby DL, Moore JR, Lehman W, Qyang Y, Campbell SG. Pathogenic Mechanisms of the Cardiomyopathy-Associated Alpha-Tropomyosin Variant E192K as Revealed by Multiscale Modeling and Experiments Biophysical Journal. 114: 495a. DOI: 10.1016/J.Bpj.2017.11.2714  0.478
2018 Viswanathan MC, Schmidt W, Madan A, Sullivan LC, Newhard CS, Rynkiewicz MJ, Lehman W, Swank DM, Cammarato A. The ACTC M305L Hypertrophic Cardiomyopathy Mutation Results in Hypercontractility and Impaired Relaxation of Drosophila Muscles Biophysical Journal. 114: 315a. DOI: 10.1016/J.Bpj.2017.11.1776  0.522
2017 Rynkiewicz MJ, Prum T, Hollenberg S, Kiani FA, Fagnant PM, Marston SB, Trybus KM, Fischer S, Moore JR, Lehman W. Tropomyosin Must Interact Weakly with Actin to Effectively Regulate Thin Filament Function. Biophysical Journal. 113: 2444-2451. PMID 29211998 DOI: 10.1016/J.Bpj.2017.10.004  0.666
2017 Viswanathan MC, Schmidt W, Rynkiewicz MJ, Agarwal K, Gao J, Katz J, Lehman W, Cammarato A. Distortion of the Actin A-Triad Results in Contractile Disinhibition and Cardiomyopathy. Cell Reports. 20: 2612-2625. PMID 28903042 DOI: 10.1016/J.Celrep.2017.08.070  0.643
2017 Rynkiewicz M, Stehn J, Gunning P, Lehman W. Structure of the Anti-Cancer Compound TR100 Target-Sites on Tpm3.1 Tropomyosin Biophysical Journal. 112. DOI: 10.1016/J.Bpj.2016.11.3019  0.483
2017 Sewanan LR, Park J, Ren Y, Urdaneta A, Rynkiewicz M, Moore J, Lehman W, Jacoby DL, Qyang Y, Campbell SG. Investigating the Phenotype of Cardiomyopathy-Associated Alpha-Tropomyosin E192K Mutation in Patient-Derived Engineered Heart Tissue Biophysical Journal. 112: 260a. DOI: 10.1016/J.Bpj.2016.11.1412  0.531
2016 Rynkiewicz MJ, Fischer S, Lehman W. The propensity for tropomyosin twisting in the presence and absence of F-actin. Archives of Biochemistry and Biophysics. PMID 27663225 DOI: 10.1016/J.Abb.2016.09.008  0.641
2016 Fischer S, Rynkiewicz MJ, Moore JR, Lehman W. Tropomyosin diffusion over actin subunits facilitates thin filament assembly. Structural Dynamics (Melville, N.Y.). 3: 012002. PMID 26798831 DOI: 10.1063/1.4940223  0.634
2016 Fischer S, Rynkiewicz MJ, Moore JR, Lehman W. Tropomyosin diffusion over actin subunits facilitates thin filament assembly Structural Dynamics. 3. DOI: 10.1063/1.4940223  0.553
2016 Farman GP, Rynkiewicz M, Orzechowski M, Lehman W, Moore J. Cardiomyopathy Linked Mutations in Alpha Tropomyosin Influence Blocked State Stability but not Myosin Strong Binding Biophysical Journal. 110: 124a-125a. DOI: 10.1016/J.Bpj.2015.11.718  0.694
2016 Rynkiewicz M, Schott V, Orzechowski M, Fischer S, Lehman W. Does Tropomyosin Slide or Roll over F-Actin during Regulatory Transitions? Biophysical Journal. 110. DOI: 10.1016/J.Bpj.2015.11.2805  0.645
2015 Rynkiewicz MJ, Schott V, Orzechowski M, Lehman W, Fischer S. Electrostatic interaction map reveals a new binding position for tropomyosin on F-actin. Journal of Muscle Research and Cell Motility. 36: 525-33. PMID 26286845 DOI: 10.1007/S10974-015-9419-Z  0.618
2010 Hartshorn KL, White MR, Rynkiewicz M, Sorensen G, Holmskov U, Head J, Crouch EC. Monoclonal antibody-assisted structure-function analysis of the carbohydrate recognition domain of surfactant protein D. American Journal of Physiology. Lung Cellular and Molecular Physiology. 299: L384-92. PMID 20601494 DOI: 10.1152/Ajplung.00096.2010  0.341
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