Jacob G Scott, MD, DPhil - Publications

Affiliations: 
2009-2016 Radiation Oncology H. Lee Moffitt Cancer Center & Research Institute, Tampa, FL, United States 
 2012-2014 Integrative Mathematical Oncology H. Lee Moffitt Cancer Center & Research Institute, Tampa, FL, United States 
 2016- Radiation Oncology Cleveland Clinic Foundation, Case Western Reserve University School of Medicine 
Area:
Mathematical Oncology: Evolutionary biology; Cancer therapy; Radiotherapy
Website:
https://www.lerner.ccf.org/thor/scott/lab/people/

57 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2023 Crozier D, Gray J, Maltas JA, Bonomo RA, Card KJ, Scott JG. The evolution of diverse antimicrobial responses in vancomycin-intermediate and its therapeutic implications. Biorxiv : the Preprint Server For Biology. PMID 38077036 DOI: 10.1101/2023.11.30.569373  0.761
2023 King ES, Pierce B, Hinczewski M, Scott JG. Diverse mutant selection windows shape spatial heterogeneity in evolving populations. Biorxiv : the Preprint Server For Biology. PMID 37732215 DOI: 10.1101/2023.03.09.531899  0.737
2022 Gopalakrishnan V, Crozier D, Card KJ, Chick LD, Krishnan NP, McClure E, Pelesko J, Williamson DFK, Nichol D, Mandal S, A Bonomo R, Scott JG. A low-cost, open-source evolutionary bioreactor and its educational use. Elife. 11. PMID 36317871 DOI: 10.7554/eLife.83067  0.742
2021 Weaver DT, McElvany BD, Gopalakrishnan V, Card KJ, Crozier D, Dhawan A, Dinh MN, Dolson E, Farrokhian N, Hitomi M, Ho E, Jagdish T, King ES, Cadnum JL, Donskey CJ, ... ... Scott JG, et al. UV decontamination of personal protective equipment with idle laboratory biosafety cabinets during the COVID-19 pandemic. Plos One. 16: e0241734. PMID 34310599 DOI: 10.1371/journal.pone.0241734  0.693
2020 Kayani BJ, Weaver DT, Gopalakrishnan V, King ES, Dolson E, Krishnan N, Pelesko J, Scott MJ, Hitomi M, Cadnum JL, Li DF, Donskey CJ, Scott JG, Charnas I. UV-C Tower for point-of-care decontamination of filtering facepiece respirators. American Journal of Infection Control. PMID 33186675 DOI: 10.1016/j.ajic.2020.11.010  0.729
2020 Grimes DR, Jansen M, Macauley RJ, Scott JG, Basanta D. Evidence for hypoxia increasing the tempo of evolution in glioblastoma. British Journal of Cancer. PMID 32848201 DOI: 10.1038/S41416-020-1021-5  0.328
2020 Scarborough JA, McClure E, Anderson P, Dhawan A, Durmaz A, Lessnick SL, Hitomi M, Scott JG. Identifying States of Collateral Sensitivity during the Evolution of Therapeutic Resistance in Ewing's Sarcoma. Iscience. 23: 101293. PMID 32623338 DOI: 10.1016/J.Isci.2020.101293  0.325
2020 Vander Velde R, Yoon N, Marusyk V, Durmaz A, Dhawan A, Miroshnychenko D, Lozano-Peral D, Desai B, Balynska O, Poleszhuk J, Kenian L, Teng M, Abazeed M, Mian O, Tan AC, ... ... Scott J, et al. Resistance to targeted therapies as a multifactorial, gradual adaptation to inhibitor specific selective pressures. Nature Communications. 11: 2393. PMID 32409712 DOI: 10.1038/S41467-020-16212-W  0.34
2020 Parsai S, Qiu RLJ, Qi P, Alfonso JCL, Donaghue J, Murray E, Majkszak D, Dorio N, Fuller CD, Brock K, Koyfman S, Woody N, Joshi N, Scott JG. Technical Note: A step-by-step guide to Temporally Feathered Radiation Therapy planning for head and neck cancer. Journal of Applied Clinical Medical Physics. PMID 32383296 DOI: 10.1002/Acm2.12893  0.316
2020 Gluzman M, Scott JG, Vladimirsky A. Optimizing adaptive cancer therapy: dynamic programming and evolutionary game theory. Proceedings. Biological Sciences. 287: 20192454. PMID 32315588 DOI: 10.1098/Rspb.2019.2454  0.308
2020 Aherne NJ, Dhawan A, Scott JG, Enderling H. Mathematical oncology and it's application in non melanoma skin cancer - A primer for radiation oncology professionals. Oral Oncology. 103: 104473. PMID 32109841 DOI: 10.1016/J.Oraloncology.2019.104473  0.616
2020 Cosper PF, Abel L, Lee YS, Paz C, Kaushik S, Nickel KP, Alexandridis R, Scott JG, Bruce JY, Kimple RJ. Patient Derived Models to Study Head and Neck Cancer Radiation Response. Cancers. 12. PMID 32059418 DOI: 10.3390/Cancers12020419  0.364
2020 Karimi AM, Campbell SR, Parsai S, Angelov L, Scott J, Qi P, Anderson P, Chao ST, Murphy ES. Aggressive Local Control With Multisite Stereotactic Body Radiation in Metastatic Ewing Sarcoma: A Literature Review and Case Report. Anticancer Research. 40: 951-955. PMID 32014939 DOI: 10.21873/Anticanres.14028  0.301
2020 Iram S, Dolson E, Chiel J, Pelesko J, Krishnan N, Güngör Ö, Kuznets-Speck B, Deffner S, Ilker E, Scott JG, Hinczewski M. Controlling the speed and trajectory of evolution with counterdiabatic driving Nature Physics. 1-8. DOI: 10.1038/S41567-020-0989-3  0.324
2019 Scott JG, Maini PK, Anderson ARA, Fletcher AG. Inferring Tumour Proliferative Organisation from Phylogenetic Tree Measures in a Computational Model. Systematic Biology. PMID 31665523 DOI: 10.1093/Sysbio/Syz070  0.68
2019 Ahmed KA, Liveringhouse CL, Mills MN, Figura NB, Grass GD, Washington IR, Harris EE, Czerniecki BJ, Blumencranz PW, Eschrich SA, Scott JG, Diaz R, Torres-Roca JF. Utilizing the genomically adjusted radiation dose (GARD) to personalize adjuvant radiotherapy in triple negative breast cancer management. Ebiomedicine. PMID 31416721 DOI: 10.1016/J.Ebiom.2019.08.019  0.322
2019 Rockne RC, Hawkins-Daarud A, Swanson KR, Sluka JP, Glazier JA, Macklin P, Hormuth D, Jarrett AM, Lima EABDF, Oden J, Biros G, Yankeelov TE, Curtius K, Bakir IA, Wodarz D, ... ... Scott JG, et al. The 2019 Mathematical Oncology Roadmap. Physical Biology. PMID 30991381 DOI: 10.1088/1478-3975/Ab1A09  0.597
2019 Kaznatcheev A, Peacock J, Basanta D, Marusyk A, Scott JG. Fibroblasts and alectinib switch the evolutionary games played by non-small cell lung cancer. Nature Ecology & Evolution. PMID 30778184 DOI: 10.1038/S41559-018-0768-Z  0.305
2019 Nichol D, Rutter J, Bryant C, Hujer AM, Lek S, Adams MD, Jeavons P, Anderson ARA, Bonomo RA, Scott JG. Antibiotic collateral sensitivity is contingent on the repeatability of evolution. Nature Communications. 10: 334. PMID 30659188 DOI: 10.1038/S41467-018-08098-6  0.352
2019 McClure E, Hitomi M, Scarborough J, Scott J. Abstract 4746: Identifying states of collateral sensitivity during the evolution of therapy resistance in Ewing’s sarcoma Cancer Research. 79: 4746-4746. DOI: 10.1158/1538-7445.Am2019-4746  0.363
2019 Sedor G, Torres-Roca JF, Kattan MW, Scott JG. A Generalizable Competing Hazards Model of Radiation Associated Outcome Assuming Biological Heterogeneity International Journal of Radiation Oncology Biology Physics. 105. DOI: 10.1016/J.Ijrobp.2019.06.2486  0.303
2019 Peacock J, Li C, Liu X, Grass D, Liveringhouse C, Diaz R, Scott J, Torres-Roca J. Radiation Therapy Cytotoxicity Score Predicts Optimal Dose and Fractionation for Individual Patients International Journal of Radiation Oncology*Biology*Physics. 105: S178. DOI: 10.1016/J.Ijrobp.2019.06.216  0.304
2019 Scott JG, Dhawan A, Hjelmeland A, Lathia J, Chumakova A, Hitomi M, Fletcher AG, Maini PK, Anderson ARA. Recasting the Cancer Stem Cell Hypothesis: Unification Using a Continuum Model of Microenvironmental Forces Current Stem Cell Reports. 5: 22-30. DOI: 10.1007/S40778-019-0153-0  0.672
2018 Kang J, Rancati T, Lee S, Oh JH, Kerns SL, Scott JG, Schwartz R, Kim S, Rosenstein BS. Machine Learning and Radiogenomics: Lessons Learned and Future Directions. Frontiers in Oncology. 8: 228. PMID 29977864 DOI: 10.3389/Fonc.2018.00228  0.352
2018 López Alfonso JC, Parsai S, Joshi N, Godley A, Shah C, Koyfman SA, Caudell JJ, Fuller CD, Enderling H, Scott JG. Temporally feathered intensity modulated radiation therapy: a planning technique to reduce normal tissue toxicity. Medical Physics. PMID 29786861 DOI: 10.1002/Mp.12988  0.603
2018 Yoon N, Vander Velde R, Marusyk A, Scott JG. Optimal Therapy Scheduling Based on a Pair of Collaterally Sensitive Drugs. Bulletin of Mathematical Biology. PMID 29736596 DOI: 10.1007/S11538-018-0434-2  0.312
2018 Parsai S, Donaghue J, Alfonso J, Joshi N, Godley A, Caudell J, Fuller C, Enderling H, Koyfman S, Scott J. Feasibility of Temporally Feathered Intensity Modulated Radiation Therapy Plans: Techniques to Reduce Normal Tissue Toxicity International Journal of Radiation Oncology*Biology*Physics. 102: e530. DOI: 10.1016/J.Ijrobp.2018.07.1489  0.578
2018 Ahmed K, Kim Y, Naqvi S, Berglund A, Welsh E, Naghavi A, Caudell J, Harrison L, Eschrich S, Scott J, Torres-Roca J. Utilizing the Genomically Adjusted Radiation Dose (GARD) to Model Radiation Dose Personalization International Journal of Radiation Oncology*Biology*Physics. 102: S136. DOI: 10.1016/J.Ijrobp.2018.06.335  0.306
2017 McFarland C, Yaglom JA, Wojtkowiak JW, Scott J, Morse DL, Sherman MY, Mirny L. The damaging effect of passenger mutations on cancer progression. Cancer Research. PMID 28536279 DOI: 10.1158/0008-5472.Can-15-3283-T  0.302
2017 Dhawan A, Nichol D, Kinose F, Abazeed ME, Marusyk A, Haura EB, Scott JG. Collateral sensitivity networks reveal evolutionary instability and novel treatment strategies in ALK mutated non-small cell lung cancer. Scientific Reports. 7: 1232. PMID 28450729 DOI: 10.1038/S41598-017-00791-8  0.346
2017 Naghavi AO, Fernandez DC, Mesko N, Juloori A, Martinez A, Scott JG, Shah C, Harrison LB. American Brachytherapy Society consensus statement for soft tissue sarcoma brachytherapy. Brachytherapy. PMID 28342738 DOI: 10.1016/J.Brachy.2017.02.004  0.322
2017 Scott J, Marusyk A. Somatic clonal evolution: A selection-centric perspective. Biochimica Et Biophysica Acta. PMID 28161395 DOI: 10.1016/J.Bbcan.2017.01.006  0.313
2016 Scott JG, Berglund A, Schell MJ, Mihaylov I, Fulp WJ, Yue B, Welsh E, Caudell JJ, Ahmed K, Strom TS, Mellon E, Venkat P, Johnstone P, Foekens J, Lee J, et al. A genome-based model for adjusting radiotherapy dose (GARD): a retrospective, cohort-based study. The Lancet. Oncology. PMID 27993569 DOI: 10.1016/S1470-2045(16)30648-9  0.337
2016 Perni S, Mohamed AS, Scott J, Enderling H, Garden AS, Gunn GB, Rosenthal DI, Fuller CD. CT-based volumetric tumor growth velocity: A novel imaging prognostic indicator in oropharyngeal cancer patients receiving radiotherapy. Oral Oncology. 63: 16-22. PMID 27938995 DOI: 10.1016/J.Oraloncology.2016.10.022  0.576
2016 Werner B, Scott JG, Sottoriva A, Anderson AR, Traulsen A, Altrock PM. The Cancer Stem Cell Fraction in Hierarchically Organized Tumors Can Be Estimated Using Mathematical Modeling and Patient-Specific Treatment Trajectories. Cancer Research. 76: 1705-13. PMID 26833122 DOI: 10.1158/0008-5472.Can-15-2069  0.593
2016 Scott JG, Fletcher AG, Anderson AR, Maini PK. Spatial Metrics of Tumour Vascular Organisation Predict Radiation Efficacy in a Computational Model. Plos Computational Biology. 12: e1004712. PMID 26800503 DOI: 10.1371/Journal.Pcbi.1004712  0.742
2016 Ahmed K, Scott J, Diaz R, Fulp W, Torres-Roca J. Abstract P3-12-04: The genomically adjusted radiation dose (GAD) and its association with distant metastases in breast cancer: A feasible approach to precision medicine in radiation oncology Cancer Research. 76. DOI: 10.1158/1538-7445.Sabcs15-P3-12-04  0.35
2016 Ahmed K, Venkat P, Scott J, Diaz R, Fulp W, Torres-Roca J. Abstract P3-12-03: Utilizing the genomically adjusted dose (GAD) to personalize radiotherapy in adjuvant breast cancer management Cancer Research. 76. DOI: 10.1158/1538-7445.Sabcs15-P3-12-03  0.342
2016 Farhidzadeh H, Chaudhury B, Scott JG, Goldgof DB, Hall LO, Gatenby RA, Gillies RJ, Raghavan M. Signal intensity analysis of ecological defined habitat in soft tissue sarcomas to predict metastasis development Progress in Biomedical Optics and Imaging - Proceedings of Spie. 9785. DOI: 10.1117/12.2216961  0.309
2015 Nichol D, Jeavons P, Fletcher AG, Bonomo RA, Maini PK, Paul JL, Gatenby RA, Anderson AR, Scott JG. Steering Evolution with Sequential Therapy to Prevent the Emergence of Bacterial Antibiotic Resistance. Plos Computational Biology. 11: e1004493. PMID 26360300 DOI: 10.1371/Journal.Pcbi.1004493  0.742
2015 Arora D, Frakes J, Scott J, Opp D, Johnson C, Song J, Harris E. Incidental radiation to uninvolved internal mammary lymph nodes in breast cancer. Breast Cancer Research and Treatment. 151: 365-72. PMID 25929764 DOI: 10.1007/S10549-015-3400-9  0.303
2015 Gupta S, Gallaher J, Lynch C, Cook L, Araujo A, Scott J, Dhillon J, Pow-Sang J, Basanta D. Optimizing personalized treatment sequences in metastatic castration resistant prostate cancer using tumor-biomarker based computational modeling. Journal of Clinical Oncology. 33: e16014-e16014. DOI: 10.1200/Jco.2015.33.15_Suppl.E16014  0.316
2015 Ahmed K, Scott J, Johnstone P, Fulp W, Torres-Roca J, Caudell J. Rtrb-01Utilizing The Genomically Adjusted Dose (Gad) To Identify Patients For Adjuvant Radiation Dose Escalation In Glioblastoma. Neuro-Oncology. 17. DOI: 10.1093/Neuonc/Nov231.01  0.325
2014 Scott JG, Fletcher AG, Maini PK, Anderson AR, Gerlee P. A filter-flow perspective of haematogenous metastasis offers a non-genetic paradigm for personalised cancer therapy. European Journal of Cancer (Oxford, England : 1990). 50: 3068-75. PMID 25306188 DOI: 10.1016/J.Ejca.2014.08.019  0.734
2014 Gallaher J, Cook LM, Gupta S, Araujo A, Dhillon J, Park JY, Scott JG, Pow-Sang J, Basanta D, Lynch CC. Improving treatment strategies for patients with metastatic castrate resistant prostate cancer through personalized computational modeling. Clinical & Experimental Metastasis. 31: 991-9. PMID 25173680 DOI: 10.1007/S10585-014-9674-1  0.338
2014 Scott JG, Hjelmeland AB, Chinnaiyan P, Anderson AR, Basanta D. Microenvironmental variables must influence intrinsic phenotypic parameters of cancer stem cells to affect tumourigenicity. Plos Computational Biology. 10: e1003433. PMID 24453958 DOI: 10.1371/Journal.Pcbi.1003433  0.592
2013 Belmonte-Beitia J, Woolley TE, Scott JG, Maini PK, Gaffney EA. Modelling biological invasions: Individual to population scales at interfaces. Journal of Theoretical Biology. 334: 1-12. PMID 23770401 DOI: 10.1016/J.Jtbi.2013.05.033  0.482
2013 Scott JG, Basanta D, Anderson AR, Gerlee P. A mathematical model of tumour self-seeding reveals secondary metastatic deposits as drivers of primary tumour growth. Journal of the Royal Society, Interface / the Royal Society. 10: 20130011. PMID 23427099 DOI: 10.1098/Rsif.2013.0011  0.573
2013 Gerlee P, Scott J, Basanta D, Anderson A. SP-0013: A mathematical model of tumor self-seeding reveals secondary metastatic deposits as drivers of primary tumor growth Radiotherapy and Oncology. 106: S5. DOI: 10.1016/S0167-8140(15)32319-7  0.545
2013 Scott JG, Gerlee P, Basanta D, Fletcher AG, Maini PK, Anderson ARA. Mathematical modeling of the metastatic process Experimental Metastasis: Modeling and Analysis. 189-208. DOI: 10.1007/978-94-007-7835-1_9  0.617
2012 Scott J, Kuhn P, Anderson AR. Unifying metastasis--integrating intravasation, circulation and end-organ colonization. Nature Reviews. Cancer. 12: 445-6. PMID 22912952 DOI: 10.1038/Nrc3287  0.558
2012 Basanta D, Scott JG, Fishman MN, Ayala G, Hayward SW, Anderson AR. Investigating prostate cancer tumour-stroma interactions: clinical and biological insights from an evolutionary game. British Journal of Cancer. 106: 174-81. PMID 22134510 DOI: 10.1038/Bjc.2011.517  0.578
2011 Scott JG, Basanta D, Chinnaiyan P, Canoll P, Swanson KR, Anderson AR. Production of 2-hydroxyglutarate by isocitrate dehydrogenase 1-mutated gliomas: an evolutionary alternative to the Warburg shift? Neuro-Oncology. 13: 1262-4. PMID 21784755 DOI: 10.1093/Neuonc/Nor083  0.575
2011 Basanta D, Scott JG, Rockne R, Swanson KR, Anderson AR. The role of IDH1 mutated tumour cells in secondary glioblastomas: an evolutionary game theoretical view. Physical Biology. 8: 015016. PMID 21301070 DOI: 10.1088/1478-3975/8/1/015016  0.579
2011 Scott JG, Kuhn P, Anderson ARA, Newton P. Abstract 4912: A network model of circulating tumor cell dynamics: Uncovering the mechanism of metastasis Cancer Research. 71: 4912-4912. DOI: 10.1158/1538-7445.Am2011-4912  0.338
2011 McFarland CD, Scott JG, Basanta D, Anderson ARA, Mirny LA. Abstract 24: A genetic model of metastatic evolution: Driver and passenger mutations affect metastatic fitness Cancer Research. 71: 24-24. DOI: 10.1158/1538-7445.Am2011-24  0.328
2011 Basanta D, Scott JG, Fishman MN, Ayala GE, Hayward SW, Anderson ARA. Investigating prostate cancer tumour-stroma interactions – clinical and biological insights from an evolutionary game Nature Precedings. 6: 1-1. DOI: 10.1038/Npre.2011.6385.1  0.325
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