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Richard H. P. Porter, PhD - Publications

Affiliations: 
Roche, Indianapolis, IN, United States 
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37 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2015 Jaeschke G, Kolczewski S, Spooren W, Vieira E, Bitter-Stoll N, Boissin P, Borroni E, Büttelmann B, Ceccarelli S, Clemann N, David B, Funk C, Guba W, Harrison A, Hartung T, ... ... Porter RH, et al. Metabotropic glutamate receptor 5 negative allosteric modulators: discovery of 2-chloro-4-[1-(4-fluorophenyl)-2,5-dimethyl-1H-imidazol-4-ylethynyl]pyridine (basimglurant, RO4917523), a promising novel medicine for psychiatric diseases. Journal of Medicinal Chemistry. 58: 1358-71. PMID 25565255 DOI: 10.1021/jm501642c  0.92
2012 Cellini J, Pommier R, Porter R, LePard KJ. Enhanced nerve-stimulated muscarinic and neurokinin contractions of ileum from streptozotocin guinea-pigs. Autonomic & Autacoid Pharmacology. 32: 23-39. PMID 22676206 DOI: 10.1111/j.1474-8673.2012.00471.x  0.92
2011 Lindemann L, Jaeschke G, Michalon A, Vieira E, Honer M, Spooren W, Porter R, Hartung T, Kolczewski S, Büttelmann B, Flament C, Diener C, Fischer C, Gatti S, Prinssen EP, et al. CTEP: a novel, potent, long-acting, and orally bioavailable metabotropic glutamate receptor 5 inhibitor. The Journal of Pharmacology and Experimental Therapeutics. 339: 474-86. PMID 21849627 DOI: 10.1124/jpet.111.185660  0.92
2011 Wallace TL, Porter RH. Targeting the nicotinic alpha7 acetylcholine receptor to enhance cognition in disease. Biochemical Pharmacology. 82: 891-903. PMID 21741954 DOI: 10.1016/j.bcp.2011.06.034  0.92
2011 Kratochwil NA, Gatti-McArthur S, Hoener MC, Lindemann L, Christ AD, Green LG, Guba W, Martin RE, Malherbe P, Porter RH, Slack JP, Winnig M, Dehmlow H, Grether U, Hertel C, et al. G protein-coupled receptor transmembrane binding pockets and their applications in GPCR research and drug discovery: a survey. Current Topics in Medicinal Chemistry. 11: 1902-24. PMID 21470172 DOI: 10.2174/156802611796391267  0.92
2011 Malherbe P, Knoflach F, Hernandez MC, Hoffmann T, Schnider P, Porter RH, Wettstein JG, Ballard TM, Spooren W, Steward L. Characterization of RO4583298 as a novel potent, dual antagonist with in vivo activity at tachykinin NK₁ and NK₃ receptors. British Journal of Pharmacology. 162: 929-46. PMID 21039418 DOI: 10.1111/j.1476-5381.2010.01096.x  0.92
2009 Achermann G, Ballard TM, Blasco F, Broutin PE, Büttelmann B, Fischer H, Graf M, Hernandez MC, Hilty P, Knoflach F, Koblet A, Knust H, Kurt A, Martin JR, Masciadri R, ... Porter RH, et al. Discovery of the imidazo[1,5-a][1,2,4]-triazolo[1,5-d][1,4]benzodiazepine scaffold as a novel, potent and selective GABA(A) alpha5 inverse agonist series. Bioorganic & Medicinal Chemistry Letters. 19: 5746-52. PMID 19726184 DOI: 10.1016/j.bmcl.2009.07.153  0.92
2008 Malherbe P, Masciadri R, Norcross RD, Knoflach F, Kratzeisen C, Zenner MT, Kolb Y, Marcuz A, Huwyler J, Nakagawa T, Porter RH, Thomas AW, Wettstein JG, Sleight AJ, Spooren W, et al. Characterization of (R,S)-5,7-di-tert-butyl-3-hydroxy-3-trifluoromethyl-3H-benzofuran-2-one as a positive allosteric modulator of GABAB receptors. British Journal of Pharmacology. 154: 797-811. PMID 18536733 DOI: 10.1038/bjp.2008.135  0.92
2008 Gillespie RJ, Adams DR, Bebbington D, Benwell K, Cliffe IA, Dawson CE, Dourish CT, Fletcher A, Gaur S, Giles PR, Jordan AM, Knight AR, Knutsen LJ, Lawrence A, Lerpiniere J, ... ... Porter RH, et al. Antagonists of the human adenosine A2A receptor. Part 1: Discovery and synthesis of thieno[3,2-d]pyrimidine-4-methanone derivatives. Bioorganic & Medicinal Chemistry Letters. 18: 2916-9. PMID 18406614 DOI: 10.1016/j.bmcl.2008.03.075  0.92
2007 Jaeschke G, Porter R, Büttelmann B, Ceccarelli SM, Guba W, Kuhn B, Kolczewski S, Huwyler J, Mutel V, Peters JU, Ballard T, Prinssen E, Vieira E, Wichmann J, Spooren W. Synthesis and biological evaluation of fenobam analogs as mGlu5 receptor antagonists. Bioorganic & Medicinal Chemistry Letters. 17: 1307-11. PMID 17196387 DOI: 10.1016/j.bmcl.2006.12.033  0.92
2007 Ceccarelli SM, Jaeschke G, Buettelmann B, Huwyler J, Kolczewski S, Peters JU, Prinssen E, Porter R, Spooren W, Vieira E. Rational design, synthesis, and structure-activity relationship of benzoxazolones: New potent mglu5 receptor antagonists based on the fenobam structure Bioorganic and Medicinal Chemistry Letters. 17: 1302-1306. PMID 17189691 DOI: 10.1016/j.bmcl.2006.12.006  0.92
2006 Malherbe P, Kratochwil N, Mühlemann A, Zenner MT, Fischer C, Stahl M, Gerber PR, Jaeschke G, Porter RH. Comparison of the binding pockets of two chemically unrelated allosteric antagonists of the mGlu5 receptor and identification of crucial residues involved in the inverse agonism of MPEP. Journal of Neurochemistry. 98: 601-15. PMID 16805850 DOI: 10.1111/J.1471-4159.2006.03886.X  0.92
2005 Röver S, Adams DR, Bénardeau A, Bentley JM, Bickerdike MJ, Bourson A, Cliffe IA, Coassolo P, Davidson JE, Dourish CT, Hebeisen P, Kennett GA, Knight AR, Malcolm CS, Mattei P, ... ... Porter RH, et al. Identification of 4-methyl-1,2,3,4,10,10a-hexahydropyrazino[1,2-a]indoles as 5-HT2C receptor agonists. Bioorganic & Medicinal Chemistry Letters. 15: 3604-8. PMID 15975787 DOI: 10.1016/j.bmcl.2005.05.074  0.92
2005 Ballard TM, Woolley ML, Prinssen E, Huwyler J, Porter R, Spooren W. The effect of the mGlu5 receptor antagonist MPEP in rodent tests of anxiety and cognition: A comparison Psychopharmacology. 179: 218-229. PMID 15739074 DOI: 10.1007/s00213-005-2211-9  0.92
2005 Mühlemann A, Diener C, Fischer C, Piussi J, Stucki A, Porter RH. Constitutive activity modulation of human metabotropic glutamate 5a receptors in HEK293 cells: a role for key amino-terminal cysteine residues. British Journal of Pharmacology. 144: 1118-25. PMID 15700023 DOI: 10.1038/sj.bjp.0706152  0.92
2003 Malherbe P, Kratochwil N, Zenner MT, Piussi J, Diener C, Kratzeisen C, Fischer C, Porter RH. Mutational analysis and molecular modeling of the binding pocket of the metabotropic glutamate 5 receptor negative modulator 2-methyl-6-(phenylethynyl)-pyridine. Molecular Pharmacology. 64: 823-32. PMID 14500738 DOI: 10.1124/mol.64.4.823  0.92
2003 Riemer C, Borroni E, Levet-Trafit B, Martin JR, Poli S, Porter RH, Bös M. Influence of the 5-HT6 receptor on acetylcholine release in the cortex: pharmacological characterization of 4-(2-bromo-6-pyrrolidin-1-ylpyridine-4-sulfonyl)phenylamine, a potent and selective 5-HT6 receptor antagonist. Journal of Medicinal Chemistry. 46: 1273-6. PMID 12646038 DOI: 10.1021/jm021085c  0.92
2003 Patel H, Porter RH, Palmer AM, Croucher MJ. Comparison of human recombinant adenosine A2B receptor function assessed by Fluo-3-AM fluorometry and microphysiometry. British Journal of Pharmacology. 138: 671-7. PMID 12598421 DOI: 10.1038/sj.bjp.0705091  0.92
2001 Vickers SP, Easton N, Malcolm CS, Allen NH, Porter RH, Bickerdike MJ, Kennett GA. Modulation of 5-HT(2A) receptor-mediated head-twitch behaviour in the rat by 5-HT(2C) receptor agonists. Pharmacology, Biochemistry, and Behavior. 69: 643-52. PMID 11509227 DOI: 10.1016/S0091-3057(01)00552-4  0.92
2001 Quirk K, Lawrence A, Jones J, Misra A, Harvey V, Lamb H, Revell D, Porter RH, Knight AR. Characterisation of agonist binding on human 5-HT2C receptor isoforms. European Journal of Pharmacology. 419: 107-12. PMID 11426831 DOI: 10.1016/S0014-2999(01)00943-8  0.92
2000 Bebbington D, Monck NJ, Gaur S, Palmer AM, Benwell K, Harvey V, Malcolm CS, Porter RH. 3,5-Disubstituted-4-hydroxyphenyls linked to 3-hydroxy-2-methyl-4(1H)-pyridinone: potent inhibitors of lipid peroxidation and cell toxicity. Journal of Medicinal Chemistry. 43: 2779-82. PMID 10956184 DOI: 10.1021/jm990945v  0.92
2000 Vickers SP, Benwell KR, Porter RH, Bickerdike MJ, Kennett GA, Dourish CT. Comparative effects of continuous infusion of mCPP, Ro 60-0175 and d-fenfluramine on food intake, water intake, body weight and locomotor activity in rats. British Journal of Pharmacology. 130: 1305-14. PMID 10903970 DOI: 10.1038/sj.bjp.0703443  0.92
2000 Betarbet R, Porter RH, Greenamyre JT. GluR1 glutamate receptor subunit is regulated differentially in the primate basal ganglia following nigrostriatal dopamine denervation. Journal of Neurochemistry. 74: 1166-74. PMID 10693949 DOI: 10.1046/J.1471-4159.2000.741166.X  0.92
2000 Malcolm CS, Benwell KR, Lamb H, Bebbington D, Porter RH. Characterization of iodoacetate-mediated neurotoxicity in vitro using primary cultures of rat cerebellar granule cells. Free Radical Biology & Medicine. 28: 102-7. PMID 10656296 DOI: 10.1016/S0891-5849(99)00215-4  0.92
1999 Malawska B, Kulig K, Antkiewicz-Michaluk L, Porter R, Misra A, Cliffe IA. Synthesis, physicochemical properties, anticonvulsant activities, and GABA-ergic and voltage-sensitive calcium channel receptor affinities of α- substituted N-benzylamides of γ-hydroxybutyric acid 1) part 4: Search for new anticonvulsant compounds Archiv Der Pharmazie. 332: 167-174. PMID 10366902 DOI: 10.1002/(SICI)1521-4184(19995)332:5<167::AID-ARDP167>3.0.CO;2-N  0.92
1996 Blandini F, Porter RH, Greenamyre JT. Glutamate and Parkinson's disease. Molecular Neurobiology. 12: 73-94. PMID 8732541 DOI: 10.1007/Bf02740748  0.92
1996 Greene JG, Porter RH, Greenamyre JT. ARL-15896, a novel N-methyl-D-aspartate receptor ion channel antagonist: neuroprotection against mitochondrial metabolic toxicity and regional pharmacology. Experimental Neurology. 137: 66-72. PMID 8566213 DOI: 10.1006/Exnr.1996.0007  0.92
1995 Blandini F, Porter RH, Greenamyre JT. Autoradiographic study of mitochondrial complex I and glutamate receptors in the basal ganglia of rats after unilateral subthalamic lesion. Neuroscience Letters. 186: 99-102. PMID 7777208 DOI: 10.1016/0304-3940(95)11292-5  0.92
1995 Porter RH, Greenamyre JT. Regional variations in the pharmacology of NMDA receptor channel blockers: implications for therapeutic potential. Journal of Neurochemistry. 64: 614-23. PMID 7530291 DOI: 10.1046/J.1471-4159.1995.64020614.X  0.92
1994 Porter RH, Greenamyre JT. Inhibition of autoradiographic MK-801 binding by an endogenous factor. Neuroscience Letters. 169: 105-8. PMID 8047262 DOI: 10.1016/0304-3940(94)90367-0  0.92
1994 Porter RH, Greene JG, Higgins DS, Greenamyre JT. Polysynaptic regulation of glutamate receptors and mitochondrial enzyme activities in the basal ganglia of rats with unilateral dopamine depletion. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 14: 7192-9. PMID 7965108 DOI: 10.1523/Jneurosci.14-11-07192.1994  0.92
1994 Porter RH, Greenamyre JT. Regional variations in the pharmacology of AMPA receptors as revealed by receptor autoradiography. Brain Research. 664: 202-6. PMID 7534602  0.92
1994 Greenamyre JT, Porter RH. Anatomy and physiology of glutamate in the CNS. Neurology. 44: S7-13. PMID 7526272  0.92
1993 Greene JG, Porter RH, Eller RV, Greenamyre JT. Inhibition of succinate dehydrogenase by malonic acid produces an "excitotoxic" lesion in rat striatum. Journal of Neurochemistry. 61: 1151-4. PMID 8360680 DOI: 10.1111/J.1471-4159.1993.Tb03634.X  0.92
1993 Birse EF, Eaton SA, Jane DE, Jones PL, Porter RH, Pook PC, Sunter DC, Udvarhelyi PM, Wharton B, Roberts PJ. Phenylglycine derivatives as new pharmacological tools for investigating the role of metabotropic glutamate receptors in the central nervous system. Neuroscience. 52: 481-8. PMID 7680790 DOI: 10.1016/0306-4522(93)90400-A  0.92
1993 Sandhu FA, Porter RH, Eller RV, Zain SB, Salim M, Greenamyre JT. NMDA and AMPA receptors in transgenic mice expressing human beta-amyloid protein. Journal of Neurochemistry. 61: 2286-9. PMID 7504089 DOI: 10.1111/J.1471-4159.1993.Tb07471.X  0.92
1992 Porter RH, Roberts PJ, Jane DE, Watkins JC. (S)-homoquisqualate: a potent agonist at the glutamate metabotropic receptor. British Journal of Pharmacology. 106: 509-10. PMID 1324071 DOI: 10.1111/J.1476-5381.1992.Tb14366.X  0.92
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