Hiromitsu Takayama - Publications

Affiliations: 
Chiba University, Chiba-shi, Chiba-ken, Japan 

212 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2022 Shiomi S, Wilailak K, Soutome W, Takayama H, Kitajima M, Ishikawa H. Asymmetric Total Synthesis and Structure Elucidation of Huperzine H. The Journal of Organic Chemistry. PMID 35040311 DOI: 10.1021/acs.joc.1c02672  0.458
2020 Takayama H. Total Syntheses of Lycopodium and Monoterpenoid Indole Alkaloids Based on Biosynthesis-Inspired Strategies. Chemical & Pharmaceutical Bulletin. 68: 103-116. PMID 32009077 DOI: 10.1248/Cpb.C19-00872  0.337
2019 Kawabata H, Hirama T, Yanagisawa T, Sato K, Kogure N, Kitajima M, Takayama H. Asymmetric Total Synthesis of Biphenylquinolizidine Alkaloids 4″--Demethyllythridine and 14--4″--Demethyllythridine. Organic Letters. PMID 31524399 DOI: 10.1021/Acs.Orglett.9B02962  0.343
2019 Saito A, Kogure N, Kitajima M, Takayama H. Total Synthesis of (-)-14-Hydroxygelsenicine and Six Biogenetically Related Alkaloids. Organic Letters. PMID 31403318 DOI: 10.1021/Acs.Orglett.9B02703  0.349
2019 Tan MA, Takayama H. Recent Progress in the Chemistry of Pandanus Alkaloids. The Alkaloids. Chemistry and Biology. 82: 1-28. PMID 30850030 DOI: 10.1016/Bs.Alkal.2018.12.001  0.469
2015 El-Shorbagi AA, Abdel-Moty SG, Ahmed AN, Takayama H, Kitajima M, Aimi N, Sakai S. The antiviral (RNA & DNA) profile of some incomplete C-nucleosides inspired from natural ß-carboline (pyrido [3,4-b] indole) scaffold; pharmacology of the intermediates in the total synthesis Der Pharma Chemica. 7: 87-92.  0.447
2014 Tan MA, Villacorta RA, Alejandro JD, Takayama H. Iridoids and a norsesquiterpenoid from the leaves of Villaria odorata. Natural Product Communications. 9: 1229-30. PMID 25918779  0.428
2014 Wibowo A, Ahmat N, Hamzah AS, Latif FA, Norrizah JS, Khong HY, Takayama H. Identification and biological activity of secondary metabolites from Dryobalanops beccarii Phytochemistry Letters. 9: 117-122. DOI: 10.1016/J.Phytol.2014.05.001  0.376
2014 Tan MA, Concepcion CNL, Alejandro GJD, Takayama H. Chemotaxonomic relevance of the constituents from the leaves of Rothmannia merrillii Journal of Chemical and Pharmaceutical Research. 6: 779-781.  0.395
2012 Harada M, Asaba KN, Iwai M, Kogure N, Kitajima M, Takayama H. Asymmetric total synthesis of an iboga-type indole alkaloid, voacangalactone, newly isolated from Voacanga africana. Organic Letters. 14: 5800-3. PMID 23131084 DOI: 10.1021/ol3027945  0.3
2012 Wibowo A, Ahmat N, Hamzah AS, Low AL, Mohamad SA, Khong HY, Sufian AS, Manshoor N, Takayama H. Malaysianol B, an oligostilbenoid derivative from Dryobalanops lanceolata. Fitoterapia. 83: 1569-75. PMID 22982329 DOI: 10.1016/J.Fitote.2012.09.004  0.379
2012 Tan MA, Nonato MG, Kogure N, Kitajima M, Takayama H. Secondary metabolites from Pandanus simplex Biochemical Systematics and Ecology. 40: 4-5. DOI: 10.1016/j.bse.2011.09.001  0.373
2011 Kogure N, Katsuta N, Kitajima M, Takayama H. Two new alkaloids from Crinum asiaticum var. sinicum. Chemical & Pharmaceutical Bulletin. 59: 1545-8. PMID 22130378 DOI: JST.JSTAGE/cpb/59.1545  0.305
2011 Bungihan ME, Tan MA, Kitajima M, Kogure N, Franzblau SG, Dela Cruz TEE, Takayama H, Nonato MG. Bioactive metabolites of Diaporthe sp. P133, an endophytic fungus isolated from Pandanus amaryllifolius Journal of Natural Medicines. 65: 606-609. PMID 21394664 DOI: 10.1007/S11418-011-0518-X  0.448
2011 Yamada Y, Kitajima M, Kogure N, Wongseripipatana S, Takayama H. Seven new monoterpenoid indole alkaloids from Gelsemium elegans. Chemistry, An Asian Journal. 6: 166-73. PMID 20960496 DOI: 10.1002/asia.201000538  0.342
2010 Tan MA, Kitajima M, Kogure N, Nonato MG, Takayama H. Isolation of pandamarilactonine-H from the roots of Pandanus amaryllifolius and synthesis of epi -pandamarilactonine-H Journal of Natural Products. 73: 1453-1455. PMID 20701299 DOI: 10.1021/np1003998  0.466
2010 Takayama H. Isolation, structure elucidation, and asymmetric synthesis of biologically active new lycopodium alkaloids Yuki Gosei Kagaku Kyokaishi/Journal of Synthetic Organic Chemistry. 68: 457-469. DOI: 10.5059/yukigoseikyokaishi.68.457  0.314
2010 Tan MA, Kitajima M, Kogure N, Nonato MG, Takayama H. New pyrrolidine alkaloids from the roots of Pandanus amaryllifolius Tetrahedron Letters. 51: 4143-4146. DOI: 10.1016/j.tetlet.2010.05.150  0.462
2010 Tan MA, Kitajima M, Kogure N, Nonato MG, Takayama H. Isolation and total syntheses of two new alkaloids, dubiusamines-A, and -B, from Pandanus dubius Tetrahedron. 66: 3353-3359. DOI: 10.1016/j.tet.2010.02.073  0.48
2010 Takayama H, Ishikawa H, Kitajima M, Aimi N. ChemInform Abstract: Formation of an Unusual Dimeric Compound (IV) by Lead Tetraacetate Oxidation of a Corynanthe-Type Indole Alkaloid, Mitragynine (I). Cheminform. 33: no-no. DOI: 10.1002/chin.200252204  0.61
2010 Takayama H, Ichikawa T, Kitajima M, Aimi N, Lopez D, Nonato MG. ChemInform Abstract: A New Alkaloid, Pandanamine; Finding of an Anticipated Biogenetic Intermediate in Pandanus amaryllifolius Roxb. Cheminform. 32: no-no. DOI: 10.1002/chin.200129184  0.518
2010 Takayama H, Kurihara M, Kitajim M, Said IM, Aimi N. ChemInform Abstract: Structure Elucidation and Chiral-Total Synthesis of a New Indole Alkaloid, (-)-9-Methoxymitralactonine, Isolated from Mitragyna speciosa in Malaysia. Cheminform. 31: no-no. DOI: 10.1002/chin.200032172  0.321
2010 TAKAYAMA H, KURIHARA M, KITAJIMA M, SAID IM, AIMI N. ChemInform Abstract: New Indole Alkaloids from the Leaves of Malaysian Mitragyna speciosa. Cheminform. 29: no-no. DOI: 10.1002/chin.199842220  0.533
2010 KITAJIMA M, NAKAMURA M, WATANABE A, TAKAYAMA H, AIMI N. ChemInform Abstract: Synthesis and Absolute Configuration of 9-β-D-Glucosyloxycamptothecin, a New Gluco Camptothecin Isolated from Ophiorrhiza pumila Regenerated Plants. Cheminform. 29: no-no. DOI: 10.1002/chin.199820256  0.505
2010 TAKAYAMA H, SUBHADHIRASAKUL S, OHMORI O, KITAJIMA M, PONGLUX D, AIMI N. ChemInform Abstract: Hunterioside B, a Disaccharide Carrying Monoterpenoid Indole Alkaloid, from Hunteria zeylanica Cheminform. 29: no-no. DOI: 10.1002/chin.199818237  0.453
2010 KITAJIMA M, MASUMOTO S, TAKAYAMA H, AIMI N. ChemInform Abstract: Isolation and Partial Synthesis of 3(R)- and 3(S)-Deoxypumiloside; Structural Revision of the Key Metabolite from the Camptothecin Producing Plant, Ophiorrhiza pumila. Cheminform. 28: no-no. DOI: 10.1002/chin.199737242  0.509
2010 AIMI N, SHIMIZU T, SADA H, TAKAYAMA H, SAKAI S, WONGSERIPIPATANA S, PONGLUX D. ChemInform Abstract: Structures of Us-7 and Us-8: A New Type of Oxindole Alkaloids Isolated from Uncaria attenuata Korth. Cheminform. 28: no-no. DOI: 10.1002/chin.199724231  0.544
2010 TAKAYAMA H, MIYABE Y, SHITO T, KITAJIMA M, AIMI N. ChemInform Abstract: Biomimetic Synthesis of Nauclea Indole Alkaloids, Naucleidinal, and 3- epi-Naucleidinal, by Stereoselective Rearrangement of Strictosamide and the Vincoside Lactam Aglycones. Cheminform. 28: no-no. DOI: 10.1002/chin.199721227  0.511
2010 TAKAYAMA H, MAEDA M, OHBAYASHI S, KITAJIMA M, SAKAI S, AIMI N. ChemInform Abstract: The First Total Synthesis of (-)-Mitragynine, an Analgesic Indole Alkaloid in Mitragyna speciosa. Cheminform. 27: no-no. DOI: 10.1002/chin.199615245  0.507
2010 SUBHADHIRASAKUL S, TAKAYAMA H, MIYABE Y, AIMI N, PONGLUX D, SAKAI S. ChemInform Abstract: New Corymine-Related Indole Alkaloids from Hunteria zeylanica in Thailand. Cheminform. 26: no-no. DOI: 10.1002/chin.199535266  0.511
2010 SUBHADHIRASAKUL S, TAKAYAMA H, AIMI N, PONGLUX D, SAKAI S. ChemInform Abstract: Novel Indole Alkaloids from the Leaves of Rauwolfia sumatrana JACK. in Thailand. Cheminform. 26: no-no. DOI: 10.1002/chin.199511264  0.521
2010 TAKAYAMA H, TOMINAGA Y, KITAJIMA M, AIMI N, SAKAI S. ChemInform Abstract: First Synthesis of the Novel Gelsemium Alkaloids, Gelselegine (V), Gelsenicine (VI), and Gelsedine (VII) Using a Biomimetic Approach. Cheminform. 26: no-no. DOI: 10.1002/chin.199506240  0.455
2010 SUBHADHIRASAKUL S, AIMI N, TAKAYAMA H, PONGLUX D, SAKAI S. ChemInform Abstract: Hunterioside (I), First Biose Bound Monoterpenoid Indole Alkaloid from Hunteria zeylanica. Cheminform. 25: no-no. DOI: 10.1002/chin.199449257  0.457
2010 TAKAYAMA H, KOIKE T, AIMI N, SAKAI S. ChemInform Abstract: A Convenient Method for Converting Saturated Aldehydes to α,. beta.-Unsaturated Aldehydes Elongated by One Carbon Atom. The Pd(II)- Promoted Oxidation of Methyl Enol Ethers. Cheminform. 23: no-no. DOI: 10.1002/chin.199233127  0.426
2010 TAKAYAMA H, KITAJIMA M, SUDA S, AIMI N, SAKAI S, ENDRESS S, STOECKIGT J. ChemInform Abstract: Structure and Synthesis of a New Indole Alkaloid, 19(S)-Hydroxy-Nb- methylraumacline, Obtained by the Biotransformation of Ajmaline in Plant Cell Cultures of Rauwolfia serpentina Benth. Cheminform. 23: no-no. DOI: 10.1002/chin.199231266  0.524
2010 TAKAYAMA H, PHISALAPHONG C, KITAJIMA M, AIMI N, SAKAI S. ChemInform Abstract: Efficient Synthetic Pathway to the Macroline-Type Indole Alkaloids, Talcarpine (IXa) and Alstonerine (XI) from Ajmaline. Cheminform. 22: no-no. DOI: 10.1002/chin.199121276  0.465
2008 Toriizuka Y, Kinoshita E, Kogure N, Kitajima M, Ishiyama A, Otoguro K, Yamada H, Omura S, Takayama H. New lycorine-type alkaloid from Lycoris traubii and evaluation of antitrypanosomal and antimalarial activities of lycorine derivatives. Bioorganic & Medicinal Chemistry. 16: 10182-9. PMID 19013823 DOI: 10.1016/J.Bmc.2008.10.061  0.302
2008 Kaewamatawong R, Kitajima M, Kogure N, Takayama H. Flavonols from Bauhinia malabarica. Journal of Natural Medicines. 62: 364-5. PMID 18414979 DOI: 10.1007/S11418-008-0249-9  0.307
2008 Tan MA, Takayama H, Aimi N, Kitajima M, Franzblau SG, Nonato MG. Antitubercular triterpenes and phytosterols from Pandanus tectorius Soland. var. laevis Journal of Natural Medicines. 62: 232-235. PMID 18404330 DOI: 10.1007/S11418-007-0218-8  0.604
2007 Hakim EH, Achmad SA, Juliawaty LD, Makmur L, Syah YM, Aimi N, Kitajima M, Takayama H, Ghisalberti EL. Prenylated flavonoids and related compounds of the Indonesian Artocarpus (Moraceae) (Journal of Natural Medicines 60, (161-184) DOI: 10.1007/s11418-006- 0048-0) Journal of Natural Medicines. 61: 229. DOI: 10.1007/s11418-006-0106-7  0.477
2006 Hakim EH, Achmad SA, Juliawaty LD, Makmur L, Syah YM, Aimi N, Kitajima M, Takayama H, Ghisalberti EL. Prenylated flavonoids and related compounds of the Indonesian Artocarpus (Moraceae). Journal of Natural Medicines. 60: 161-184. PMID 29435895 DOI: 10.1007/S11418-006-0106-7  0.577
2006 Takayama H, Misawa K, Okada N, Ishikawa H, Kitajima M, Hatori Y, Murayama T, Wongseripipatana S, Tashima K, Matsumoto K, Horie S. New procedure to mask the 2,3-pi bond of the indole nucleus and its application to the preparation of potent opioid receptor agonists with a Corynanthe skeleton. Organic Letters. 8: 5705-8. PMID 17134252 DOI: 10.1021/Ol062173K  0.457
2006 Usman H, Hakim EH, Harlim T, Jalaluddin MN, Syah YM, Achmad SA, Takayama H. Cytotoxic chalcones and flavanones from the tree bark of Cryptocarya costata. Zeitschrift Fã¼R Naturforschung. C, Journal of Biosciences. 61: 184-8. PMID 16729574 DOI: 10.1515/Znc-2006-3-405  0.365
2006 Kitajima M, Nakamura T, Kogure N, Ogawa M, Mitsuno Y, Ono K, Yano S, Aimi N, Takayama H. Isolation of gelsedine-type indole alkaloids from Gelsemium elegans and evaluation of the cytotoxic activity of Gelsemium alkaloids for A431 epidermoid carcinoma cells Journal of Natural Products. 69: 715-718. PMID 16643063 DOI: 10.1021/Np068071K  0.573
2006 Matsumoto K, Takayama H, Ishikawa H, Aimi N, Ponglux D, Watanabe K, Horie S. Partial agonistic effect of 9-hydroxycorynantheidine on μ-opioid receptor in the guinea-pig ileum Life Sciences. 78: 2265-2271. PMID 16266723 DOI: 10.1016/J.Lfs.2005.09.030  0.569
2006 Takayama H, Katakawa K, Kitajima M, Yamaguchi K. Three New Phlegmarine-Type Lycopodium Alkaloids, Lycoposerramines-X, -Y and -Z, Having a Nitrone Residue, from Lycopodium serratum Heterocycles. 69: 223-229. DOI: 10.3987/Com-06-S(O)16  0.347
2006 Syah YM, Achmad SA, Aimi N, Hakim EH, Juliawaty LD, Takayama H. Two prenylated flavones from the tree bark of Artocarpus lanceifolius Zeitschrift Fur Naturforschung - Section B Journal of Chemical Sciences. 61: 1134-1137.  0.396
2005 Kitajima M, Fujii N, Yoshino F, Sudo H, Saito K, Aimi N, Takayama H. Camptothecins and two new monoterpene glucosides from Ophiorrhiza liukiuensis Chemical and Pharmaceutical Bulletin. 53: 1355-1358. PMID 16205003 DOI: 10.1248/cpb.53.1355  0.532
2005 Matsumoto K, Horie S, Takayama H, Ishikawa H, Aimi N, Ponglux D, Murayama T, Watanabe K. Antinociception, tolerance and withdrawal symptoms induced by 7-hydroxymitragynine, an alkaloid from the Thai medicinal herb Mitragyna speciosa Life Sciences. 78: 2-7. PMID 16169018 DOI: 10.1016/J.Lfs.2004.10.086  0.576
2005 Niampoka C, Suttisri R, Bavovada R, Takayama H, Aimi N. Potentially cytotoxic triterpenoids from the root bark of Siphonodon celastrineus Griff Archives of Pharmacal Research. 28: 546-549. PMID 15974440 DOI: 10.1007/Bf02977756  0.538
2005 Horie S, Koyama F, Takayama H, Ishikawa H, Aimi N, Ponglux D, Matsumoto K, Murayama T. Indole alkaloids of a Thai medicinal herb, Mitragyna speciosa, that has opioid agonistic effect in guinea-pig ileum Planta Medica. 71: 231-236. PMID 15770543 DOI: 10.1055/S-2005-837822  0.571
2005 Katakawa K, Kitajima M, Aimi N, Seki H, Yamaguchi K, Furihata K, Harayama T, Takayama H. Structure elucidation and synthesis of lycoposerramine-B, a novel oxime-containing Lycopodium alkaloid from Lycopodium serratum Thunb. The Journal of Organic Chemistry. 70: 658-63. PMID 15651814 DOI: 10.1021/jo0483825  0.551
2004 Kang TH, Murakami Y, Takayama H, Kitajima M, Aimi N, Watanabe H, Matsumoto K. Protective effect of rhynchophylline and isorhynchophylline on in vitro ischemia-induced neuronal damage in the hippocampus: Putative neurotransmitter receptors involved in their action Life Sciences. 76: 331-343. PMID 15531384 DOI: 10.1016/J.Lfs.2004.08.012  0.412
2004 Kitajima M, Hashimoto KI, Sandoval M, Aimi N, Takayama H. New oleanan-type triterpene and cincholic acid glycosides from Peruvian "Uña de Gato" (Uncaria tomentosa) Chemical and Pharmaceutical Bulletin. 52: 1258-1261. PMID 15467250 DOI: 10.1248/cpb.52.1258  0.528
2004 Takayama H, Mori I, Kitajima M, Aimi N, Lajis NH. New type of trimeric and pentameric indole alkaloids from Psychotria rostrata Organic Letters. 6: 2945-2948. PMID 15330654 DOI: 10.1021/ol048971x  0.565
2004 Suzuki KT, Mandal BK, Katagiri A, Sakuma Y, Kawakami A, Ogra Y, Yamaguchi K, Sei Y, Yamanaka K, Anzai K, Ohmichi M, Takayama H, Aimi N. Dimethylthioarsenicals as arsenic metabolites and their chemical preparations. Chemical Research in Toxicology. 17: 914-21. PMID 15257616 DOI: 10.1021/tx049963s  0.412
2004 Takayama H, Ishikawa H, Kitajima M, Aimi N, Aji BM. A new 9-methoxyyohimbine-type indole alkaloid from Mitragyna africanus Chemical and Pharmaceutical Bulletin. 52: 359-361. PMID 14993762 DOI: 10.1248/Cpb.52.359  0.648
2004 Matsumoto K, Horie S, Ishikawa H, Takayama H, Aimi N, Ponglux D, Watanabe K. Antinociceptive effect of 7-hydroxymitragynine in mice: Discovery of an orally active opioid analgesic from the Thai medicinal herb Mitragyna speciosa Life Sciences. 74: 2143-2155. PMID 14969718 DOI: 10.1016/J.Lfs.2003.09.054  0.615
2004 Ogura J, Mitamura M, Someya A, Shimamura K, Takayama H, Aimi N, Horie S, Murayama T. Mesaconitine-induced relaxation in rat aorta: Role of Na +/Ca2+ exchangers in endothelial cells European Journal of Pharmacology. 483: 139-146. PMID 14729101 DOI: 10.1016/J.Ejphar.2003.10.022  0.394
2004 Yamazaki Y, Kitajima M, Arita M, Takayama H, Sudo H, Yamazaki M, Aimi N, Saito K. Biosynthesis of Camptothecin. In Silico and in Vivo Tracer Study from [1-13C]Glucose Plant Physiology. 134: 161-170. PMID 14657405 DOI: 10.1104/Pp.103.029389  0.449
2004 Aimi N, Ariffin J, Takayama H, Kitajima M, Kaneko C. Density Functional Theory Study of the Preferred Conformation of Geissoschizine Heterocycles. 63: 663. DOI: 10.3987/Com-03-9971  0.444
2004 Hakim EH, Achmad SA, Aimi N, Indrayanto G, Kitajima M, Makmur L, Surya MD, Syah YM, Takayama H. Regioselective glucosylation of oxyresveratrol by cell suspension cultures of Solanum mammosum Journal of Chemical Research. 2004: 706-707. DOI: 10.3184/0308234043431825  0.465
2003 Kitajima M, Urano A, Kogure N, Takayama H, Aimi N. New oxindole alkaloids and iridoid from carolina jasmine (Gelsemium sempervirens AIT. f.) Chemical and Pharmaceutical Bulletin. 51: 1211-1214. PMID 14519934 DOI: 10.1248/Cpb.51.1211  0.552
2003 Takayama H, Katakawa K, Kitajima M, Yamaguchi K, Aimi N. Ten new Lycopodium alkaloids having the lycopodane skeleton isolated from Lycopodium serratum Thunb. Chemical & Pharmaceutical Bulletin. 51: 1163-9. PMID 14519922  0.509
2003 Watanabe H, Zhao Q, Matsumoto K, Tohda M, Murakami Y, Zhang SH, Kang TH, Mahakunakorn P, Maruyama Y, Sakakibara I, Aimi N, Takayama H. Pharmacological evidence for antidementia effect of Choto-san (Gouteng-san), a traditional Kampo medicine Pharmacology Biochemistry and Behavior. 75: 635-643. PMID 12895681 DOI: 10.1016/S0091-3057(03)00109-6  0.459
2003 Syah YM, Aminah NS, Hakim EH, Aimi N, Kitajima M, Takayama H, Achmad SA. Two oligostilbenes, cis- and trans-diptoindonesin B, from Dryobalanops oblongifolia Phytochemistry. 63: 913-917. PMID 12895539 DOI: 10.1016/S0031-9422(03)00274-7  0.494
2003 Takayama H, Fujiwara R, Kasai Y, Kitajima M, Aimi N. First asymmetric total synthesis of Us-7 and -8, novel D-seco Corynanthe-type oxindole alkaloids from Uncaria attenuata: structure revision of Us-7 and determination of absolute stereochemistry. Organic Letters. 5: 2967-70. PMID 12889920 DOI: 10.1021/ol035128a  0.503
2003 Kitajima M, Kogure N, Yamaguchi K, Takayama H, Aimi N. Structure reinvestigation of gelsemoxonine, a constituent of Gelsemium elegans, reveals a novel, azetidine-containing indole alkaloid Organic Letters. 5: 2075-2078. PMID 12790532 DOI: 10.1021/ol0344725  0.544
2003 Yamazaki Y, Urano A, Sudo H, Kitajima M, Takayama H, Yamazaki M, Aimi N, Saito K. Metabolite profiling of alkaloids and strictosidine synthase activity in camptothecin producing plants Phytochemistry. 62: 461-470. PMID 12620359 DOI: 10.1016/S0031-9422(02)00543-5  0.455
2003 Kitajima M, Hashimoto KI, Yokoya M, Takayama H, Sandoval M, Aimi N. Two new nor-triterpene glycosides from Peruvian "Uña de Gato" (Uncaria tomentosa) Journal of Natural Products. 66: 320-323. PMID 12608878 DOI: 10.1021/Np0203741  0.593
2003 Husain K, Jantan I, Said IM, Aimi N, Takayama H. Two new methyl chanofruticosinates from Kopsia flavida blume Journal of Asian Natural Products Research. 5: 63-67. PMID 12608641 DOI: 10.1080/1028602031000080487  0.537
2003 Takayama H, Tsutsumi SI, Kitajima M, Santiarworn D, Liawruangrath B, Aimi N. Gluco-indole alkaloids from Nauclea cadamba in Thailand and transformation of 3α-dihydrocadambine into the indolopyridine alkaloid, 16-carbomethoxynaufoline Chemical and Pharmaceutical Bulletin. 51: 232-233. PMID 12576667 DOI: 10.1248/cpb.51.232  0.471
2003 Permana D, Lajis NH, Shaari K, Ali AM, Mackeen MMM, Kitajima M, Takayama H, Aimi N. A New Prenylated Hydroquinone from the Roots of Garcinia atroviridis Griff ex T. Anders (Guttiferae) Zeitschrift FüR Naturforschung. B, a Journal of Chemical Sciences. 58: 332-335. DOI: 10.1515/Znb-2003-0414  0.561
2003 Takayama H, Fujiwara R, Kasai Y, Kitajima M, Aimi N. First asymmetric total synthesis of Us-7 and -8, novel D-seco Corynanthe-type oxindole alkaloids from uncaria attenuata: Structure revision of Us-7 and determination of absolute stereochemistry Organic Letters. 5: 2967-2970. DOI: 10.1021/ol035128a  0.51
2003 Tiew P, Takayama H, Kitajima M, Aimi N, Kokpol U, Chavasiri W. A novel neolignan, mansoxetane, and two new sesquiterpenes, mansonones R and S, from Mansonia gagei Tetrahedron Letters. 44: 6759-6761. DOI: 10.1016/S0040-4039(03)01616-2  0.562
2002 Hakim EH, Asnizar, Yurnawilis, Aimi N, Kitajima M, Takayama H. Artoindonesianin P, a new prenylated flavone with cytotoxic activity from Artocarpus lanceifolius Fitoterapia. 73: 668-673. PMID 12490227 DOI: 10.1016/S0367-326X(02)00226-5  0.569
2002 Kobayashi Y, Ogra Y, Ishiwata K, Takayama H, Aimi N, Suzuki KT. Selenosugars are key and urinary metabolites for selenium excretion within the required to low-toxic range Proceedings of the National Academy of Sciences of the United States of America. 99: 15932-15936. PMID 12441402 DOI: 10.1073/Pnas.252610699  0.456
2002 Kang TH, Murakami Y, Matsumoto K, Takayama H, Kitajima M, Aimi N, Watanabe H. Rhynchophylline and isorhynchophylline inhibit NMDA receptors expressed in Xenopus oocytes European Journal of Pharmacology. 455: 27-34. PMID 12433591 DOI: 10.1016/S0014-2999(02)02581-5  0.486
2002 Aimi N, Kitajima M, Yokoya M, Takayama H, Sakamoto S, Yamaguchi K. Collision-induced dissociation actualized the H+-promoted reaction as observed in vitro; harman formation from β-carboline-type monoterpenoid glucoindole alkaloids Chemical and Pharmaceutical Bulletin. 50: 1528-1529. PMID 12419926 DOI: 10.1248/Cpb.50.1528  0.494
2002 Aminah NS, Achmad SA, Aimi N, Ghisalberti EL, Hakim EH, Kitajima M, Syah YM, Takayama H. Diptoindonesin A, a new C-glucoside of ε-viniferin from Shorea seminis (Dipterocarpaceae) Fitoterapia. 73: 501-507. PMID 12385874 DOI: 10.1016/S0367-326X(02)00179-X  0.568
2002 Kitajima M, Yokoya M, Takayama H, Aimi N. Synthesis and absolute configuration of a new 3,4-dihydro-β-carboline- type alkaloid, 3,4-dehydro-5(S)-5-carboxystrictosidine, isolated from Peruvian Uña de Gato (Uncaria tomentosa) Chemical and Pharmaceutical Bulletin. 50: 1376-1378. PMID 12372867 DOI: 10.1002/chin.200314216  0.536
2002 Takayama H, Ichikawa T, Kitajima M, Nonato MG, Aimi N. Isolation and structure elucidation of two new alkaloids, pandamarilactonine-C and -D, from Pandanus amaryllifolius and revision of relative stereochemistry of pandamarilactonine-A and -B by total synthesis Chemical and Pharmaceutical Bulletin. 50: 1303-1304. PMID 12237561 DOI: 10.1248/cpb.50.1303  0.537
2002 Takayama H, Arai M, Kitajima M, Aimi N. First Total Synthesis of a Novel Monoterpenoid Isoquinoline Alkaloid, (±)-Alangine Chemical and Pharmaceutical Bulletin. 50: 1141-1143. PMID 12192157 DOI: 10.1002/chin.200303186  0.473
2002 Kang TH, Matsumoto K, Tohda M, Murakami Y, Takayama H, Kitajima M, Aimi N, Watanabe H. Pteropodine and isopteropodine positively modulate the function of rat muscarinic M1 and 5-HT2 receptors expressed in Xenopus oocyte European Journal of Pharmacology. 444: 39-45. PMID 12191580 DOI: 10.1016/S0014-2999(02)01608-4  0.405
2002 Kaewamatawong R, Likhitwitayawuid K, Ruangrungsi N, Takayama H, Kitajima M, Aimi N. Novel biflavonoids from the stem bark of Ochna integerrima Journal of Natural Products. 65: 1027-1029. PMID 12141866 DOI: 10.1021/Np010630U  0.548
2002 Takayama H, Ishikawa H, Kitajima M, Aimi N. Formation of an unusual dimeric compound by lead tetraacetate oxidation of a Corynanthe-type indole alkaloid, mitragynine Chemical and Pharmaceutical Bulletin. 50: 960-963. PMID 12130854 DOI: 10.1248/Cpb.50.960  0.626
2002 Tsuchiya S, Miyashita S, Yamamoto M, Horie S, Sakai SI, Aimi N, Takayama H, Watanabe K. Effect of mitragynine, derived from Thai folk medicine, on gastric acid secretion through opioid receptor in anesthetized rats European Journal of Pharmacology. 443: 185-188. PMID 12044808 DOI: 10.1016/S0014-2999(02)01588-1  0.415
2002 Takayama H, Ishikawa H, Kurihara M, Kitajima M, Aimi N, Ponglux D, Koyama F, Matsumoto K, Moriyama T, Yamamoto LT, Watanabe K, Murayama T, Horie S. Studies on the synthesis and opioid agonistic activities of mitragynine-related indole alkaloids: Discovery of opioid agonists structurally different from other opioid ligands Journal of Medicinal Chemistry. 45: 1949-1956. PMID 11960505 DOI: 10.1021/Jm010576E  0.594
2002 Ogra Y, Ishiwata K, Takayama H, Aimi N, Suzuki KT. Identification of a novel selenium metabolite, Se-methyl-N-acetylselenohexosamine, in rat urine by high-performance liquid chromatography-inductively coupled plasma mass spectrometry and -electrospray ionization tandem mass spectrometry Journal of Chromatography B: Analytical Technologies in the Biomedical and Life Sciences. 767: 301-312. PMID 11885859 DOI: 10.1016/S1570-0232(01)00581-5  0.413
2002 Juliawaty LD, Watanabe Y, Kitajima M, Achmad SA, Takayama H, Aimi N. First total synthesis and determination of the absolute configuration of strictifolione, a new 6-(ω-phenylalkenyl)-5,6-dihydro-α-pyrone, isolated from Cryptocarya strictifolia Tetrahedron Letters. 43: 8657-8660. DOI: 10.1016/S0040-4039(02)02181-0  0.516
2002 Ishikawa H, Takayama H, Aimi N. Dimerization of indole derivatives with hypervalent iodines(III): A new entry for the concise total synthesis of rac- and meso-chimonanthines Tetrahedron Letters. 43: 5637-5639. DOI: 10.1016/S0040-4039(02)01137-1  0.622
2002 Kitajima M, Yoshida S, Yamagata K, Nakamura M, Takayama H, Saito K, Seki H, Aimi N. Camptothecin-related alkaloids from hairy roots of Ophiorrhiza pumila Tetrahedron. 58: 9169-9178. DOI: 10.1016/S0040-4020(02)01196-1  0.448
2001 Takayama H, Katakawa K, Kitajima M, Seki H, Yamaguchi K, Aimi N. A new type of lycopodium alkaloid, lycoposerramine-A, from Lycopodium serratum Thunb. Organic Letters. 3: 4165-7. PMID 11784168 DOI: 10.1021/ol0167762  0.504
2001 Suhartati T, Achmad SA, Aimi N, Hakim EH, Kitajima M, Takayama H, Takeya K. Artoindonesianin L, a new prenylated flavone with cytotoxic activity from Artocarpus rotunda Fitoterapia. 72: 912-918. PMID 11731116 DOI: 10.1016/S0367-326X(01)00343-4  0.533
2001 Takayama H, Ichikawa T, Kitajima M, Nonato MG, Aimi N. Isolation and characterization of two new alkaloids, norpandamarilactonine-A and -B, from Pandanus amaryllifolius by spectroscopic and synthetic methods Journal of Natural Products. 64: 1224-1225. PMID 11575961 DOI: 10.1021/Np010213H  0.592
2001 Nagakubo J, Tomimatsu T, Kitajima M, Takayama H, Aimi N, Horie T. Characteristics of transport of fluoresceinated methotrexate in rat small intestine Life Sciences. 69: 739-747. PMID 11487087 DOI: 10.1016/S0024-3205(01)01162-6  0.447
2001 Permana D, Lajis NH, Mackeen MM, Ali AM, Aimi N, Kitajima M, Takayama H. Isolation and bioactivities of constitutents of the roots of Garcinia atroviridis. Journal of Natural Products. 64: 976-9. PMID 11473441 DOI: 10.1021/Np000563O  0.586
2001 Husain K, Jantan I, Kamaruddin N, Said IM, Aimi N, Takayama H. Methyl chanofruticosinates from leaves of Kopsia flavida Blume Phytochemistry. 57: 603-606. PMID 11394866 DOI: 10.1016/S0031-9422(01)00119-4  0.535
2001 Takayama H, Ishikawa H, Kurihara M, Kitajima M, Sakai SI, Aimi N, Seki H, Yamaguchi K, Said IM, Houghton PJ. Structure revision of mitragynaline, an indole alkaloid in Mitragyna speciosa Tetrahedron Letters. 42: 1741-1743. DOI: 10.1016/S0040-4039(01)00006-5  0.658
2001 Saito K, Sudo H, Yamazaki M, Koseki-Nakamura M, Kitajima M, Takayama H, Aimi N. Feasible production of camptothecin by hairy root culture of Ophiorrhiza pumila Plant Cell Reports. 20: 267-271. DOI: 10.1007/S002990100320  0.51
2001 Kitajima M, Hashimoto K, Yokoya M, Takayama H, Aimi N, Sakai S. ChemInform Abstract: A New Gluco Indole Alkaloid, 3,4-Dehydro-5-carboxystrictosidine, from Peruvian Una de Gato (Uncaria tomentosa). Cheminform. 32: no-no. DOI: 10.1002/chin.200111210  0.523
2001 Takayama H, Aimi N, Sakai S. ChemInform Abstract: Chemical Studies on the Analgesic Indole Alkaloids from the Traditional Medicine (Mitragyna speciosa) Used for Opium Substitute Cheminform. 32: no-no. DOI: 10.1002/chin.200106242  0.498
2000 Mohamed AFAF, Matsumoto K, Tabata K, Takayama H, Kitajima M, Aimi N, Watanabe H. Effects of Uncaria tomentosa total alkaloid and its components on experimental amnesia in mice: Elucidation using the passive avoidance test Journal of Pharmacy and Pharmacology. 52: 1553-1561. PMID 11197086 DOI: 10.1211/0022357001777612  0.497
2000 Juliawaty LD, Kitajima M, Takayama H, Achmad SA, Aimi N. A new type of stilbene-related secondary metabolite, idenburgene, from Cryptocarya idenburgensis Chemical and Pharmaceutical Bulletin. 48: 1726-1728. PMID 11086902 DOI: 10.1248/Cpb.48.1726  0.597
2000 Takayama H, Aimi N, Sakai SI. Chemical studies on the analgesic indole alkaloids from the traditional medicine (Mitragyna speciosa) used for opium substitute Yakugaku Zasshi. 120: 959-967. PMID 11082707 DOI: 10.1248/Yakushi1947.120.10_959  0.594
2000 Kitajima M, Hashimoto K, Yokoya M, Takayama H, Aimi N, Sakai SI. A new gluco indole alkaloid, 3, 4-dehydro-5-carboxystrictosidine, from Peruvian Uña de Gato (Uncaria tomentosa). Chemical & Pharmaceutical Bulletin. 48: 1410-2. PMID 11045440 DOI: 10.1248/cpb.48.1410  0.541
2000 Juliawaty LD, Kitajima M, Takayama H, Achmad SA, Aimi N. A 6-substituted-5,6-dihydro-2-pyrone from Cryptocarya strictifolia Phytochemistry. 54: 989-993. PMID 11014303 DOI: 10.1016/S0031-9422(00)00077-7  0.509
2000 Makmur L, Syamsurizal, Tukiran, Achmad SA, Aimi N, Hakim EH, Kitajima M, Takayama H. Artoindonesianin c, a new xanthone derivative from artocarpus teysmanii Journal of Natural Products. 63: 243-244. PMID 10691717 DOI: 10.1021/Np990220U  0.578
2000 Takayama H, Ichikawa T, Kuwajima T, Kitajima M, Seki H, Ainu N, Nonato MG. Structure characterization, biomimetic total synthesis, and optical purity of two new pyrrolidine alkaloids, pandamarilactonine-A and -B, isolated from Pandanus amaryllifolius Roxb Journal of the American Chemical Society. 122: 8635-8639. DOI: 10.1021/Ja0009929  0.391
2000 Kitajima M, Hashimoto K, Yokoya M, Takayama H, Aimi N. Two New 19-Hydroxyursolic Acid-type Triterpenes from Peruvian ‘Uña de Gato’ ( Uncaria tomentosa ) Tetrahedron. 56: 547-552. DOI: 10.1016/S0040-4020(99)01048-0  0.457
2000 Takayama H, Watanabe F, Kuroda A, Kitajima M, Aimi N. Formation of a Novel 1-Aza-tricyclo[5.3.0.04,8]decane System via Tandem Radical Cyclization of a Tryptophan Derivative Tetrahedron. 56: 6457-6461. DOI: 10.1016/S0040-4020(00)00601-3  0.429
2000 Takayama H, Kurihara M, Kitajima M, Said IM, Aimi N. Structure elucidation and chiral-total synthesis of a new indole alkaloid, (-)-9-methoxymitralactonine, isolated from Mitragyna speciosa in Malaysia Tetrahedron. 56: 3145-3151. DOI: 10.1016/S0040-4020(00)00235-0  0.598
1999 Takayama H, Kurihara M, Kitajima M, Said IM, Aimi N. Isolation and Asymmetric Total Synthesis of a New Mitragyna Indole Alkaloid, (-)-Mitralactonine. The Journal of Organic Chemistry. 64: 1772-1773. PMID 11674259 DOI: 10.1021/Jo9823644  0.604
1999 Fujiwara M, Kodama EN, Okamoto M, Tokuhisa K, Ide T, Hanasaki Y, Katsuura K, Takayama H, Aimi N, Mitsuya H, Shigeta S, Konno K, Yokota T, Baba M. Characterization of human immunodeficiency virus type 1 strains resistant to the non-nucleoside reverse transcriptase inhibitor RD4-2217. Antiviral Chemistry & Chemotherapy. 10: 315-20. PMID 10628806 DOI: 10.1177/095632029901000602  0.495
1999 Masumiya H, Saitoh T, Tanaka Y, Horie S, Aimi N, Takayama H, Tanaka H, Shigenobu K. Effects of hirsutine and dihydrocorynantheine on the action potentials of sino-atrial node, atrium and ventricle. Life Sciences. 65: 2333-41. PMID 10597888 DOI: 10.1016/S0024-3205(99)00500-7  0.485
1999 Yamamoto LT, Horie S, Takayama H, Aimi N, Sakai S, Yano S, Shan J, Pang PK, Ponglux D, Watanabe K. Opioid receptor agonistic characteristics of mitragynine pseudoindoxyl in comparison with mitragynine derived from Thai medicinal plant Mitragyna speciosa. General Pharmacology. 33: 73-81. PMID 10428019 DOI: 10.1016/S0306-3623(98)00265-1  0.501
1999 TAKAYAMA H, KITAJIMA M, AIMI N. Chemistry of Camptothecin and its Related Alkaloids. Journal of Synthetic Organic Chemistry, Japan. 57: 181-193. DOI: 10.5059/Yukigoseikyokaishi.57.181  0.507
1999 Takayama H, Kuwajima T, Kitajima M, Nonato MG, Aimi N. First Total Synthesis of the Pandanus Alkaloids, Pandamarilactam-3Y and -3X Heterocycles. 50: 75-78. DOI: 10.3987/Com-98-S(H)54  0.488
1999 OHMORI O, TAKAYAMA H, KITAJIMA M, AIMI N. First Synthesis of Neoalangiside, a New Tetrahydroisoquinoline-monoterpene Glucoside with Oxygen Functions at Unusual C1, C2 Positions. Chemical & Pharmaceutical Bulletin. 47: 1512-1513. DOI: 10.1248/Cpb.47.1512  0.527
1999 Ohmori O, Takayama H, Aimi N. First synthesis of hunterioside, a novel disaccharide carrying monoterpenoid indole alkaloid, by assembly of three components, tryptamine, secologanin, and a newly-developed glucosyl donor Tetrahedron Letters. 40: 5039-5042. DOI: 10.1016/S0040-4039(99)00928-4  0.568
1999 Takayama H, Shimizu T, Sada H, Harada Y, Kitajima M, Aimi N. Stereochemical studies on the Uncaria alkaloid, 3-oxo-7-hydroxy-3,7- secorhynchophylline: The absolute configuration of 3-hydroxyoxindole derivatives Tetrahedron. 55: 6841-6846. DOI: 10.1016/S0040-4020(99)00337-3  0.547
1998 Takayama H, Watanabe A, Hosokawa M, Chiba K, Satoh T, Aimi N. Synthesis of a new class of camptothecin derivatives, the long-chain fatty acid esters of 10-hydroxycamptothecin, as a potent prodrug candidate, and their in vitro metabolic conversion by carboxylesterases. Bioorganic & Medicinal Chemistry Letters. 8: 415-8. PMID 9871589 DOI: 10.1016/S0960-894X(98)00039-0  0.52
1998 Leewanich P, Tohda M, Matsumoto K, Subhadhirasakul S, Takayama H, Aimi N, Watanabe H. Inhibitory effects of corymine-related compounds on glycine receptors expressed in Xenopus oocytes. Japanese Journal of Pharmacology. 77: 169-72. PMID 9681574 DOI: 10.1254/Jjp.77.169  0.527
1998 Leewanich P, Tohda M, Matsumoto K, Subhadhirasakul S, Takayama H, Aimi N, Watanabe H. A possible mechanism underlying corymine inhibition of glycine-induced Cl- current in Xenopus oocytes. European Journal of Pharmacology. 348: 271-7. PMID 9652343 DOI: 10.1016/S0014-2999(98)00147-2  0.483
1998 Thongpradichote S, Matsumoto K, Tohda M, Takayama H, Aimi N, Sakai S, Watanabe H. Identification of opioid receptor subtypes in antinociceptive actions of supraspinally-administered mitragynine in mice. Life Sciences. 62: 1371-8. PMID 9585164 DOI: 10.1016/S0024-3205(98)00075-7  0.487
1998 Takayama H, Ohmori O, Sakai M, Funahashi M, Kitajima M, Santiarworn D, Liawruangrath B, Aimi N. Isolation, Partial Synthesis and Stereochemical Study of 10-Hydroxystrictosamide, a Constituent of Nauclea orientalis in Thailand Heterocycles. 49: 49. DOI: 10.3987/Com-98-S12  0.577
1998 Aimi N, Takayama H, Subhadhirasakul S, Ohmori O, Kitajima M, Ponglux D. Hunterioside B, a Disaccharide Carrying Monoterpenoid Indole Alkaloid, from Hunteria zeylanica Heterocycles. 47: 87. DOI: 10.3987/Com-97-S(N)28  0.504
1998 Takayama H, Sakai S. Chapter 11 Monoterpenoid Indole Alkaloid Syntheses Utilizing Biomimetic Reactions The Alkaloids: Chemistry and Biology. 50: 415-452. DOI: 10.1016/S1099-4831(08)60049-8  0.362
1998 Abdel-Moty SG, Sakai S, Aimi N, Takayama H, Kitajima M, El-Shorbagi A, Ahmed AN, Omar NM. Synthesis of cytotoxic 1-polyhydroxyalkyl-β-carboline derivatives European Journal of Medicinal Chemistry. 32: 1009-1017. DOI: 10.1016/S0223-5234(97)89645-6  0.546
1998 Ohmori O, Kumazawa K, Hoshino H, Suzuki T, Morishima Y, Kohno H, Kitajima M, Sakai S, Takayama H, Aimi N. Final solution on the long-standing structural arguments on the C-3 stereochemistries of three glucoindole alkaloids: Palicoside, dolichantoside, and isodolichantoside — through chemical conversions and spectroscopic studies Tetrahedron Letters. 39: 7737-7740. DOI: 10.1016/S0040-4039(98)01686-4  0.531
1998 Takayama H, Kurihara M, Kitajima M, Said IM, Aimi N. New indole alkaloids from the leaves of malaysian: Mitragyna speciosa Tetrahedron. 54: 8433-8440. DOI: 10.1016/S0040-4020(98)00464-5  0.6
1998 Kitajima M, Fischer U, Nakamura M, Ohsawa M, Ueno M, Takayama H, Unger M, Stöckigt J, Aimi N. Anthraquinones from Ophiorrhiza pumila tissue and cell cultures Phytochemistry. 48: 107-111. DOI: 10.1016/S0031-9422(97)00614-6  0.512
1997 Leewanich P, Tohda M, Matsumoto K, Subhadhirasakul S, Takayama H, Aimi N, Watanabe H. Inhibitory effects of corymine, an alkaloidal component from the leaves of Hunteria zeylanica, on glycine receptors expressed in Xenopus oocytes. European Journal of Pharmacology. 332: 321-6. PMID 9300267 DOI: 10.1016/S0014-2999(97)01097-2  0.474
1997 Matsumoto K, Mizowaki M, Takayama H, Sakai S, Aimi N, Watanabe H. Suppressive effect of mitragynine on the 5-methoxy-N,N-dimethyltryptamine-induced head-twitch response in mice. Pharmacology, Biochemistry, and Behavior. 57: 319-23. PMID 9164589 DOI: 10.1016/S0091-3057(96)00314-0  0.484
1997 Fujiwara M, Ijichi K, Hanasaki Y, Ide T, Katsuura K, Takayama H, Aimi N, Shigeta S, Konno K, Yokota T, Baba M. Thiadiazole derivatives: highly potent and selective inhibitors of human immunodeficiency virus type 1 (HIV-1) replications in vitro. Microbiology and Immunology. 41: 301-8. PMID 9159403 DOI: 10.1111/J.1348-0421.1997.Tb01205.X  0.493
1997 Tohda M, Thongpraditchote S, Matsumoto K, Murakami Y, Sakai S, Aimi N, Takayama H, Tongroach P, Watanabe H. Effects of mitragynine on cAMP formation mediated by delta-opiate receptors in NG108-15 cells. Biological & Pharmaceutical Bulletin. 20: 338-40. PMID 9145205 DOI: 10.1248/Bpb.20.338  0.498
1997 KOSHIISHI I, TAKAYAMA H, AIMI N, YAMAGUCHI K, TOYODA H, IMANARI T. A Novel Reaction of Cyanate with Dehydroascorbate. Chemical & Pharmaceutical Bulletin. 45: 344-348. DOI: 10.1248/Cpb.45.344  0.526
1997 Aimi N, Shimizu T, Sada H, Takayama H, Sakai S, Wongseripipatana S, Ponglux D. Structures of Us-7 and Us-8: a new type of oxindole alkaloids isolated fromUncaria attenuata Korth Journal of the Chemical Society-Perkin Transactions 1. 187-188. DOI: 10.1039/A607017E  0.585
1997 Hamzah AS, Jasmani H, Ahmad R, Baba AR, Lajis NH, Aimi N, Kitajima M, Takayama H. New anthraquinones from the roots of Hedyotis dichotoma Journal of Natural Products. 60: 36-37. DOI: 10.1021/Np960583J  0.581
1997 Takayama H, Iimura Y, Kitajima M, Aimi N, Konno K, Inoue H, Fujiwara M, Mizuta T, Yokota T, Shigeta S, Tokuhisa K, Hanasaki Y, Katsuura K. Discovery of anti-influenza A virus activity of a corynanthe-type indole alkaloid, hirsutine, in vitro and the structure-activity relationship of natural and synthetic analogs Bioorganic and Medicinal Chemistry Letters. 7: 3145-3148. DOI: 10.1016/S0960-894X(97)10154-8  0.534
1997 Konno K, Inoue H, Fujiwara M, Mizuta T, Takayama H, Iimura Y, Aimi N, Tokuhisa K, Hanasaki Y, Katsuura K, Shigeta S, Yokota T. Inhibitory effect of hirsutine on influenza virus replication in vitro Antiviral Research. 34: A88. DOI: 10.1016/S0166-3542(97)83306-2  0.456
1997 Kitajima M, Nakamura M, Takayama H, Saito K, Stöckigt J, Aimi N. Constituents of regenerated plants of Ophiorrhiza pumila; formation of a new glycocamptothecin and predominant formation of (3R)-deoxypumiloside over (3S)-congener Tetrahedron Letters. 38: 8997-9000. DOI: 10.1016/S0040-4039(97)10404-X  0.34
1997 Takayama H, Watanabe F, Kitajima M, Aimi N. A radical cyclization strategy for the concise total synthesis of (±)-geissoschizine Tetrahedron Letters. 38: 5307-5310. DOI: 10.1016/S0040-4039(97)01186-6  0.498
1997 Kitajima M, Masumoto S, Takayama H, Aimi N. Isolation and Partial synthesis of 3(R)- and 3(S)-deoxypumiloside; structural revision of the key metabolite from the camptothecin producing plant, Ophiorrhiza pumila Tetrahedron Letters. 38: 4255-4258. DOI: 10.1016/S0040-4039(97)00858-7  0.505
1997 Ismail NH, Ali AM, Aimi N, Kitajima M, Takayama H, Lajis NH. Anthraquinones from Morinda elliptica Phytochemistry. 45: 1723-1725. DOI: 10.1016/S0031-9422(97)00252-5  0.431
1996 Matsumoto K, Mizowaki M, Suchitra T, Murakami Y, Takayama H, Sakai S, Aimi N, Watanabe H. Central antinociceptive effects of mitragynine in mice: contribution of descending noradrenergic and serotonergic systems. European Journal of Pharmacology. 317: 75-81. PMID 8982722 DOI: 10.1016/S0014-2999(96)00714-5  0.487
1996 Leewanich P, Tohda M, Matsumoto K, Subhadhirasakul S, Takayama H, Aimi N, Watanabe H. Behavioral studies on alkaloids extracted from the leaves of Hunteria zeylanica. Biological & Pharmaceutical Bulletin. 19: 394-9. PMID 8924908 DOI: 10.1248/Bpb.19.394  0.482
1996 Matsumoto K, Mizowaki M, Suchitra T, Takayama H, Sakai S, Aimi N, Watanabe H. Antinociceptive action of mitragynine in mice: evidence for the involvement of supraspinal opioid receptors. Life Sciences. 59: 1149-55. PMID 8831802 DOI: 10.1016/0024-3205(96)00432-8  0.493
1996 Ijichi K, Fujiwara M, Nagano H, Matsumoto Y, Hanasaki Y, Ide T, Katsuura K, Takayama H, Shirakawa S, Aimi N, Shigeta S, Konno K, Matsushima M, Yokota T, Baba M. Anti-HIV-1 activity of thiadiazole derivatives: structure-activity relationship, reverse transcriptase inhibition, and lipophilicity. Antiviral Research. 31: 87-94. PMID 8793012 DOI: 10.1016/0166-3542(96)00950-3  0.495
1996 Takayama H, Kurihara M, Subhadhirasakul S, Kitajima M, Aimi N, Sakai S. Stereochemical Assignment of Pseudoindoxyl Alkaloids Heterocycles. 42: 87. DOI: 10.3987/Com-95-S27  0.352
1996 KITAJIMA M, SHIRAKAWA S, ABDEL-MOTY SGA, TAKAYAMA H, SAKAI S, AIMI N, STOCKIGT J. Structure and Synthesis of a New Chiral .BETA.-Carboline Found in Cultured Cell Clumps of Rauwolfia serpentina and Rhazya stricta. Chemical & Pharmaceutical Bulletin. 44: 2195-2197. DOI: 10.1248/Cpb.44.2195  0.586
1996 TAKAYAMA H, MIYABE Y, SHITO T, KITAJIMA M, AIMI N. Biomimetic Synthesis of Nauclea Indole Alkaloids, Naucleidinal, and 3-epi-Naucleidinal, by Stereoselective Rearrangement of Strictsamide and the Vincoside Lactam Aglycones. Chemical & Pharmaceutical Bulletin. 44: 2192-2194. DOI: 10.1248/cpb.44.2192  0.508
1996 AIMI N, KITAJIMA M, OYA N, NITTA W, TAKAYAMA H, SAKAI S, KOSTENYUK I, GLEBA Y, ENDREB S, STOCKIGT J. Isolation of Alkaloids from Cultured Hybrid Cells of Rauwolfia serpentina*Rhazya stricta. Chemical & Pharmaceutical Bulletin. 44: 1637-1639. DOI: 10.1248/Cpb.44.1637  0.3
1996 Takayama H, Shirakawa S, Kitajima M, Aimi N, Yamaguchi K, Hanasaki Y, Ide T, Katsuura K, Fujiwara M, Ijichi K, Konno K, Sigeta S, Yokota T, Baba M. Utilization of Wieland furoxan synthesis for preparation of 4-aryl-1,2,5-oxadiazole-3-yl carbamate derivatives having potent anti-HIV activity Bioorganic and Medicinal Chemistry Letters. 6: 1993-1996. DOI: 10.1016/0960-894X(96)00355-1  0.516
1996 Nagano H, Ijichi K, Fujiwara M, Matsumoto Y, Konno K, Yokota T, Matsushima M, Hanasaki Y, Katsuura K, Takayama H, Aimi N, Baba M, Shigeta S. Structure - activity relationship of non-nucleoside RT inhibitor, thiadizaole derivatives Antiviral Research. 30: A30. DOI: 10.1016/0166-3542(96)80265-8  0.51
1995 Subhadhirasakul S, Takayama H, Miyabe Y, Kitajima M, Ponglux D, Sakai S, Aimi N. Two novel sarpagine-type indole alkaloids from the leaves of Hunteria zeylanica in Thailand Heterocycles. 41: 2049-2056. DOI: 10.3987/Com-95-7170  0.541
1995 Takayama H, Morikawa M, Kitajima M, Sakai Si, Aimi N. Synthesis and conformational analysis of a new Indole Alkaloid, 2,7-Dihydroxyapogeissoschizine Natural Product Letters. 7: 81-84. DOI: 10.1080/10575639508043193  0.552
1995 Takayama H, Sakai S. Recent advances in the chemistry of Gelsemium alkaloids Studies in Natural Products Chemistry. 15: 465-518. DOI: 10.1016/S1572-5995(06)80141-9  0.384
1995 Takayama H, Maeda M, Ohbayashi S, Kitajima M, Sakai Si, Aimi N. The first total synthesis of (-)-mitragynine, an analgesic indole alkaloid in mitragyna speciosa Tetrahedron Letters. 36: 9337-9340. DOI: 10.1016/0040-4039(95)02022-H  0.543
1995 TAKAYAMA H, YAMAMOTO R, KURIHARA M, KITAJIMA M, AIMI N, MAO L, SAKAI S. ChemInform Abstract: On the Indole Alkaloid, Nauclefidine; Structure Revision, Synthesis, and a Biomimetic Transformation from the Vincoside Lactam. Cheminform. 26: no-no. DOI: 10.1002/chin.199516272  0.505
1994 Ponglux D, Wongseripipatana S, Takayama H, Kikuchi M, Kurihara M, Kitajima M, Aimi N, Sakai S. A New Indole Alkaloid, 7 alpha-Hydroxy-7H-mitragynine, from Mitragyna speciosa in Thailand. Planta Medica. 60: 580-1. PMID 17236085 DOI: 10.1055/S-2006-959578  0.506
1994 Subhadhirasakul S, Aimi N, Takayama H, Ponglux D, Sakai S. Hunterioside, first biose bound monoterpenoid indole alkaloid from Hunteria zeylanica. Chemical & Pharmaceutical Bulletin. 42: 991-3. PMID 8020135 DOI: 10.1248/Cpb.42.991  0.555
1994 Sakai S, Takayama H. Biomimetic chemical transformation from simple indole alkaloids to Gelsemium alkaloids Pure and Applied Chemistry. 66: 2139-2142. DOI: 10.1351/Pac199466102139  0.434
1994 TAKAYAMA H, SUDA S, CHEN I, KITAJIMA M, AIMI N, SAKAI S. Two New Dimeric Indole Alkaloids from Tabernaemontana subglobosa MERR. from Taiwan. Chemical & Pharmaceutical Bulletin. 42: 280-284. DOI: 10.1248/cpb.42.280  0.515
1994 SUBHADHIRASAKUL S, TAKAYAMA H, MIYABE Y, AIMI N, PONGLUX D, SAKAI S. New Corymine-Related Indole Alkaloids from Hunteria zeylanica in Thailand. Chemical & Pharmaceutical Bulletin. 42: 2645-2646. DOI: 10.1248/Cpb.42.2645  0.574
1994 TAKAYAMA H, SUBHADHIRASAKUL S, MIZUKI J, KITAJIMA M, AIMI N, PONGLUX D, SAKAI S. A New Class of Two Dimeric Indole Alkaloids, Coryzeylamine and Deformylcoryzeylamine, from the Leaves of Hunteria zeylanica in Thailand. Chemical & Pharmaceutical Bulletin. 42: 1957-1959. DOI: 10.1248/Cpb.42.1957  0.393
1994 SUBHADHIRASAKUL S, TAKAYAMA H, AIMI N, PONGLUX D, SAKAI S. Novel Indole Alkaloids from the Leaves of Rauwolfia sumatrana JACK. in Thailand. Chemical & Pharmaceutical Bulletin. 42: 1427-1431. DOI: 10.1248/Cpb.42.1427  0.57
1994 Takayama H, Wongseripipatana S, Morohoshi Y, Ponglux D, Kitajima M, Aimi N, Sakai Si. Two New Iridoros From The Leaves Of Gelsemium Elegans Benth. In Thailand Natural Product Letters. 5: 15-20. DOI: 10.1080/10575639408043929  0.599
1994 Kitajima M, Takayama H, Sakai S. Synthesis of a novel gelsedine-type gelsemium alkaloid, gelsemicine Journal of the Chemical Society-Perkin Transactions 1. 1573-1578. DOI: 10.1039/P19940001573  0.361
1994 Takayama H, Nitta W, Kitajima M, Aimi N, Sakai S. A New Gardneria Alkaloid, Gardquinolone, Having a Novel 4-Quinolone Skeleton Journal of Natural Products. 57: 521-523. DOI: 10.1021/Np50106A014  0.615
1994 Takayama H, Tominaga Y, Kitajima M, Aimi N, Sakai S. First Synthesis of the Novel Gelsemium Alkaloids, Gelselegine, Gelsenicine, and Gelsedine Using a Biomimetic Approach The Journal of Organic Chemistry. 59: 4381-4385. DOI: 10.1021/Jo00095A010  0.566
1994 Takayama H, Yamamoto R, Kurihara M, Kitajima M, Aimi N, Mao L, Sakai Si. On the indole alkaloid, nauclefidine; structure revision, synthesis, and a biomimetic transformation from the vincoside lactam Tetrahedron Letters. 35: 8813-8816. DOI: 10.1016/S0040-4039(00)78505-4  0.497
1994 Takayama H, Kitajima M, Sakai S. A biomimetic synthesis of a new skeletal Gelsemium alkaloid, 11-methoxy-19(R)-hydroxygelselegine Tetrahedron. 50: 11813-11820. DOI: 10.1016/S0040-4020(01)89296-6  0.339
1994 Takayama H, Kitajima M, Sakai S. A biomimetic synthesis of a novel seco indole alkaloid, 11-methoxygelsemamide Tetrahedron. 50: 8363-8370. DOI: 10.1016/S0040-4020(01)85559-9  0.4
1994 Keawpradub N, Takayama H, Aimi N, Sakai SI. Indole alkaloids from Alstonia glaucescens Phytochemistry. 37: 1745-1749. DOI: 10.1016/S0031-9422(00)89603-X  0.547
1993 SEKI H, TAKAYAMA H, AIMI N, SAKAI S, PONGLUX D. A Nuclear Magnetic Resonance Study on the Eleven Stereoisomers of Heteroyohimbine-Type Oxindole Alkaloids. Chemical & Pharmaceutical Bulletin. 41: 2077-2086. DOI: 10.1248/Cpb.41.2077  0.486
1993 Takayama H, Seki N, Kitajima M, Aimi N, Sakai SI. Application Of Tungstate-Catalyzed Oxidation To The Conversion of Oxindoles Into The Corresponding Na-Methoxyoxindoles In The Gelsemium AlkaloidSynthesis Natural Product Letters. 2: 271-276. DOI: 10.1080/10575639308043821  0.508
1993 Phisalaphong C, Takayama H, Sakai S. A First synthesis of 20-hydroxydihydrorankinidine, a new oxindole alkaloid from Gelsemium elegans benth. Tetrahedron Letters. 34: 4035-4038. DOI: 10.1016/S0040-4039(00)60609-3  0.387
1993 Endreß S, Takayama H, Suda S, Kitajima M, Aimi N, Sakai SI, Stöckigt J. Alkaloids from Rauwolfia serpentina cell cultures treated with ajmaline Phytochemistry. 32: 725-730. DOI: 10.1016/S0031-9422(00)95161-6  0.561
1992 Endreß S, Suda S, Takayama H, Aimi N, Sakai S, Stöckigt J. Isolation, Identification, and Chemical Synthesis of 6alpha-Hydroxyraumacline: A Novel Alkaloid from Cultivated Rauwolfia serpentina Cells. Planta Medica. 58: 410-2. PMID 17226497 DOI: 10.1055/S-2006-961502  0.558
1992 Takayama H, Katsura M, Seki N, Kitajima M, Aimi N, Sakai S, Santiarworn D, Liawruangrath B. Elaeocarpidine, a Naturally Occurring Racemate, from Tarenna vanprukii. Planta Medica. 58: 289-91. PMID 17226473 DOI: 10.1055/S-2006-961462  0.485
1992 TAKAYAMA H, HITOTSUYANAGI Y, YAMAGUCHI K, AIMI N, SAKAI S. On the Alkaloidal Constituents of Aconitum sanyoense NAKAI var. tonense NAKAI. Chemical & Pharmaceutical Bulletin. 40: 2927-2931. DOI: 10.1248/Cpb.40.2927  0.582
1992 Endreß S, Suda S, Takayama H, Kitajima M, Aimi N, Sakai S, Stöckigt J. Biotransformation of Ajmaline in Cell Suspension Cultures ofRauwolfia serpentina Planta Medica. 58: 618-618. DOI: 10.1055/S-2006-961617  0.461
1992 Takayama H, Kitajima M, Ogata K, Sakai S. The first and biomimetic construction of the new skeleton of gelselegine-type oxindole alkaloids The Journal of Organic Chemistry. 57: 4583-4584. DOI: 10.1021/Jo00043A011  0.343
1992 Takayama H, Koike T, Aimi N, Sakai S. A convenient method for converting saturated aldehydes to .alpha.,.beta.-unsaturated aldehydes elongated by one carbon atom. The palladium(II)-promoted oxidation of methyl enol ethers The Journal of Organic Chemistry. 57: 2173-2176. DOI: 10.1021/Jo00033A050  0.49
1992 Takayama H, Watanabe T, Seki H, Aimi N, Sakai Si. Geissoschizine revisited - definite proof of its stereostructure Tetrahedron Letters. 33: 6831-6834. DOI: 10.1016/S0040-4039(00)61787-2  0.508
1992 Takayama H, Kitajima M, Suda S, Aimi N, Sakai Si, Endreß S, Stöckigt J. Structure and Synthesis of a New Indole Alkaloid, 19 (S)-Hydroxy-Nb-methylraumacline, Obtained by the Biotransformation of Ajmaline in Plant Cell Cultures of Rauwolfia Serpentina Benth Tetrahedron. 48: 2627-2634. DOI: 10.1016/S0040-4020(01)88525-2  0.597
1991 KOIKE T, TAKAYAMA H, SAKAI S. Synthetic Studies on the Picraline-Type Indole Alkaloids-I: Improved Synthesis of C-Mavacurine-Type Compounds and a New Skeletal Rearrangement in a Corynanthe-Type Derivative. Chemical & Pharmaceutical Bulletin. 39: 1677-1681. DOI: 10.1248/Cpb.39.1677  0.36
1991 Aimi N, Uchida N, Ohya N, Hosokawa H, Takayama H, Sakai Si, Mendonza LA, Polz L, Stöckigt J. Novel indole alkaloids from cell suspension cultures of aspidosperma quebracho blanco schlecht Tetrahedron Letters. 32: 4949-4952. DOI: 10.1016/S0040-4039(00)93504-4  0.572
1991 Takayama H, Phisalaphong C, Kitajima M, Aimi N, Sakai Si. An efficient synthetic pathway to the macroline-type indole alkaloids, talcarpine and alstonerine from ajmaline Tetrahedron. 47: 1383-1392. DOI: 10.1016/S0040-4020(01)86414-0  0.547
1990 Takayama H, Yokota M, Aimi N, Sakai S, Lu S, Chen I. Two New Diterpene Alkaloids, 10-Hydroxyneoline and 14-O-Acetyl-10-hydroxyneoline, from Aconitum fukutomei Journal of Natural Products. 53: 936-939. DOI: 10.1021/Np50070A023  0.508
1990 Takayama H, Odaka H, Aimi N, Sakai S. Synthetic studies on gelsedine alkaloids-II: first construction of gelsedine skeleton (Na-desmethoxygelsemicine) from gardnerine based on the alternative biogenetic speculation. Tetrahedron Letters. 31: 5483-5486. DOI: 10.1016/S0040-4039(00)97878-X  0.551
1990 Polz L, Stöckigt J, Takayama H, Uchida N, Aimi N, Sakai S. Biotransformation of ajmaline in plant cell cultures of rauwolfia serpentina benth.: The new indole alkaloids raumacline and N(b)-methylraumacline. Tetrahedron Letters. 31: 6693-6696. DOI: 10.1016/S0040-4039(00)97149-1  0.577
1990 Takayama H, Horigome M, Aimi N, Sakai S. Synthetic studies on gelsedine alkaloids-i: Stereoselective preparation of hypothetical biogenetic intermediates, D-norsarpagine type compounds from ajmaline. Tetrahedron Letters. 31: 1287-1290. DOI: 10.1016/S0040-4039(00)88787-0  0.541
1989 TAKAYAMA H, HITOTSUYANAGI Y, YAMAGUCHI K, AIMI N, SAKAI S. Two new diterpene alkaloids, 10-hydroxyisotalatizidine and 10-hydroxy-talatizamine. Chemical & Pharmaceutical Bulletin. 37: 548-550. DOI: 10.1248/Cpb.37.548  0.583
1989 Takayama H, Sun J, Aimi N, Sakai S, Lu S, Chen I. Lassiocarpine, a novel C20-diterpene alkaloid isolated from aconitum kojimae ohwi Tetrahedron Letters. 30: 3441-3442. DOI: 10.1016/S0040-4039(00)99266-9  0.586
1989 Takayama H, Masubuchi K, Kitajima M, Aimi N, Sakai S. A biomimetic construction of humantenine skeleton Tetrahedron. 45: 1327-1336. DOI: 10.1016/0040-4020(89)80131-0  0.502
1989 TAKAYAMA H, MASUBUCHI K, KITAJIMA M, AIMI N, SAKAI S. ChemInform Abstract: A Biomimetic Construction of the Humantenine Skeleton. Cheminform. 20. DOI: 10.1002/chin.198927314  0.418
1988 Takayama H, Okazaki T, Yamaguchi K, Aimi N, Haginiwa J, Sakai S. Structure of two new diterpene alkaloids, 3-epi-ignavinol and 2,3-dehydrodelcosine. Chemical & Pharmaceutical Bulletin. 36: 3210-3212. DOI: 10.1248/Cpb.36.3210  0.589
1988 Ponglux D, Wongseripipatana S, Takayama H, Ogata K, Aimi N, Sakai S. A new class of indole alkaloid ‘elegansamine’ constructed from a monoterpenoid indole alkaloid and an iridoid Tetrahedron Letters. 29: 5395-5396. DOI: 10.1016/S0040-4039(00)82877-4  0.556
1988 Ponglux D, Wongseripipatana S, Subhadhirasakul S, Takayama H, Yokota M, Ogata K, Phisalaphong C, Aimi N, Sakai S. Studies on the indole alkaloids of gelsem1um elegans (thailand): structure elucidation and proposal of biogenetic route Tetrahedron. 44: 5075-5094. DOI: 10.1016/S0040-4020(01)86012-9  0.575
1987 Sakai S, Wongseripipatana S, Ponglux D, Yokota M, Ogata K, Takayama H, Aimi N. Indole alkaloids isolated from Gelsemium elegans (Thailand): 19-(Z)-akuammidine, 16-epi-voacarpine, 19-hydroxydihydrogelsevirine, and the revised structure of koumidine. Chemical & Pharmaceutical Bulletin. 35: 4668-4671. DOI: 10.1248/Cpb.35.4668  0.572
1987 Sakai S, Okazaki T, Yamaguchi K, Takayama H, Aimi N. Structures of torokonine and gomandonine, two new diterpene alkaloids from Aconitum subcuneatum Nakai. Chemical & Pharmaceutical Bulletin. 35: 2615-2617. DOI: 10.1248/Cpb.35.2615  0.593
1987 Takayama H, Yamaguchi K, Okazaki T, Aimi N, Sakai S. Chemical conversion of lycotonine into an aconitine alkaloid, 7-deoxylycoctonine Journal of the Chemical Society, Chemical Communications. 818-820. DOI: 10.1039/C39870000818  0.523
1986 Takayama H, Hayashi K, Koizumi T. Enantioselective total synthesis of Glyoxalase I inhibitor using asymmetric Diels-Alder reaction of a new chiral dienophile, ()S-3-(3-triflouromethylpyrid-2-ylsulfinyl)acrylate. Tetrahedron Letters. 27: 5509-5512. DOI: 10.1016/S0040-4039(00)85252-1  0.312
1986 Takayama H, Iyobe A, Koizumi T. The First Efficient Asymmetric Synthesis of 7-Oxabicyclo[2.2.1]hept-5-ene-2-carboxylate Derivatives. Cheminform. 17. DOI: 10.1002/Chin.198644064  0.303
1984 SAKAI S, TAKAYAMA H, YAMAGUCHI K, IDE N, OKAMOTO T. Partial Synthesis of Isodelphinine and Penduline Yakugaku Zasshi. 104: 731-752. DOI: 10.1248/Yakushi1947.104.7_731  0.305
1982 TAKAYAMA H, HASEGAWA S, SAKAI S, HAGINIWA J, OKAMOTO T. On the Alkaloids of Aconitum japonicum THUNB. collected at Mt. Mineoka (Chiba Pref.) : Structure Elucidation and Partial Synthesis of a New Alkaloid, 15-α-Hydroxyneoline Yakugaku Zasshi. 102: 525-532. DOI: 10.1248/Yakushi1947.102.6_525  0.354
1982 TAKAYAMA H, TOKITA AN, ITO M, SAKAI S, KUROSAKI F, OKAMOTO T. On the Alkaloids of Aconitum yesoense NAKAI Yakugaku Zasshi. 102: 245-257. DOI: 10.1248/Yakushi1947.102.3_245  0.413
1982 Sakai S, Yamamoto I, Yamaguchi K, Takayama H, Ito M, Okamoto T. The structure of the new diterpene alkaloid nominine and the absolute configuration of kobusine. Chemical & Pharmaceutical Bulletin. 30: 4579-4582. DOI: 10.1248/Cpb.30.4579  0.388
1981 Sakai S, Takayama H, Ito M, Koga M, Sasaki S, Okamoto T. Structure of Ezochasmanine, Ezochasmaconitine, Anisoezochasmaconitine and Synthesis of Vilmorrianine A Heterocycles. 15: 403. DOI: 10.3987/S-1981-01-0403  0.338
1981 TAKAYAMA H, HASEGAWA S, SAKAI S, HAGINIWA J, OKAMOTO T. Structure elucidation of a new aconite alkaloid, 15-.ALPHA.-hydroxyneoline. Chemical & Pharmaceutical Bulletin. 29: 3078-3080. DOI: 10.1248/Cpb.29.3078  0.391
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