| Year |
Citation |
Score |
| 2023 |
Stonedahl S, Leser JS, Clarke P, Potter H, Boyd TD, Tyler KL. Treatment with Granulocyte-Macrophage Colony-Stimulating Factor Reduces Viral Titers in the Brains of West Nile Virus-Infected Mice and Improves Survival. Journal of Virology. e0180522. PMID 36802227 DOI: 10.1128/jvi.01805-22 |
0.402 |
|
| 2022 |
Stonedahl S, Leser JS, Clarke P, Tyler KL. Depletion of Microglia in an Brain Slice Culture Model of West Nile Virus Infection Leads to Increased Viral Titers and Cell Death. Microbiology Spectrum. 10: e0068522. PMID 35412380 DOI: 10.1128/spectrum.00685-22 |
0.436 |
|
| 2022 |
Potter H, Kendall L, Boyd T, Sillau S, Bosco-Lauth A, Markham N, Fong D, Clarke P, Tyler K. GM-CSF Promotes Immune Response and Survival in a Mouse Model of COVID-19. Research Square. PMID 35118463 DOI: 10.21203/rs.3.rs-1213395/v1 |
0.323 |
|
| 2021 |
Clarke P, Leser JS, Tyler KL. Intrinsic innate immune responses control viral growth and protect against neuronal death in an model of WNV-induced CNS disease. Journal of Virology. JVI0083521. PMID 34190599 DOI: 10.1128/JVI.00835-21 |
0.373 |
|
| 2020 |
Stonedahl S, Clarke P, Tyler KL. The Role of Microglia during West Nile Virus Infection of the Central Nervous System. Vaccines. 8. PMID 32872152 DOI: 10.3390/Vaccines8030485 |
0.516 |
|
| 2020 |
Potter H, Boyd TD, Clarke P, Pelak VS, Tyler KL. Recruiting the innate immune system with GM-CSF to fight viral diseases, including West Nile Virus encephalitis and COVID-19. F1000research. 9: 345. PMID 32704352 DOI: 10.12688/F1000Research.23729.1 |
0.356 |
|
| 2019 |
Hixon AM, Frost J, Rudy MJ, Messacar K, Clarke P, Tyler KL. Understanding Enterovirus D68-Induced Neurologic Disease: A Basic Science Review. Viruses. 11. PMID 31487952 DOI: 10.3390/V11090821 |
0.327 |
|
| 2019 |
Bonney S, Seitz S, Ryan CA, Jones KL, Clarke P, Tyler KL, Siegenthaler JA. Gamma Interferon Alters Junctional Integrity via Rho Kinase, Resulting in Blood-Brain Barrier Leakage in Experimental Viral Encephalitis. Mbio. 10. PMID 31387911 DOI: 10.1128/Mbio.01675-19 |
0.419 |
|
| 2019 |
Clarke P, Zhuang Y, Berens HM, Leser JS, Tyler KL. Interferon-β contributes to astrocyte activation in the brain following reovirus infection. Journal of Virology. PMID 30814290 DOI: 10.1128/Jvi.02027-18 |
0.481 |
|
| 2018 |
Seitz S, Clarke P, Tyler KL. Pharmacologic depletion of microglia increases viral load in the brain and enhances mortality in murine models of Flavivirus-induced encephalitis. Journal of Virology. PMID 29899084 DOI: 10.1128/Jvi.00525-18 |
0.509 |
|
| 2017 |
Quick ED, Seitz S, Clarke P, Tyler KL. Minocycline has anti-inflammatory effects and reduces cytotoxicity in an ex vivo spinal cord slice culture model of West Nile virus infection. Journal of Virology. PMID 28878079 DOI: 10.1128/Jvi.00569-17 |
0.424 |
|
| 2017 |
Hixon AM, Yu G, Leser JS, Yagi S, Clarke P, Chiu CY, Tyler KL. A mouse model of paralytic myelitis caused by enterovirus D68. Plos Pathogens. 13: e1006199. PMID 28231269 DOI: 10.1371/Journal.Ppat.1006199 |
0.354 |
|
| 2016 |
Zhuang Y, Berens-Norman HM, Leser JS, Clarke P, Tyler KL. Mitochondrial p53 contributes to reovirus-induced neuronal apoptosis and CNS injury in a mouse model of viral encephalitis. Journal of Virology. PMID 27307572 DOI: 10.1128/Jvi.00583-16 |
0.407 |
|
| 2014 |
Quick ED, Leser JS, Clarke P, Tyler KL. Activation of intrinsic immune responses and microglial phagocytosis in an ex vivo spinal cord slice culture model of West Nile virus infection. Journal of Virology. 88: 13005-14. PMID 25165111 DOI: 10.1128/Jvi.01994-14 |
0.449 |
|
| 2014 |
Clarke P, Leser JS, Bowen RA, Tyler KL. Virus-induced transcriptional changes in the brain include the differential expression of genes associated with interferon, apoptosis, interleukin 17 receptor A, and glutamate signaling as well as flavivirus-specific upregulation of tRNA synthetases. Mbio. 5: e00902-14. PMID 24618253 DOI: 10.1128/Mbio.00902-14 |
0.504 |
|
| 2014 |
Clarke P, Leser JS, Quick ED, Dionne KR, Beckham JD, Tyler KL. Death receptor-mediated apoptotic signaling is activated in the brain following infection with West Nile virus in the absence of a peripheral immune response. Journal of Virology. 88: 1080-9. PMID 24198425 DOI: 10.1128/Jvi.02944-13 |
0.51 |
|
| 2013 |
Dionne KR, Zhuang Y, Leser JS, Tyler KL, Clarke P. Daxx upregulation within the cytoplasm of reovirus-infected cells is mediated by interferon and contributes to apoptosis. Journal of Virology. 87: 3447-60. PMID 23302889 DOI: 10.1128/Jvi.02324-12 |
0.425 |
|
| 2012 |
Schittone SA, Dionne KR, Tyler KL, Clarke P. Activation of innate immune responses in the central nervous system during reovirus myelitis. Journal of Virology. 86: 8107-18. PMID 22623770 DOI: 10.1128/Jvi.00171-12 |
0.434 |
|
| 2011 |
Dionne KR, Galvin JM, Schittone SA, Clarke P, Tyler KL. Type I interferon signaling limits reoviral tropism within the brain and prevents lethal systemic infection. Journal of Neurovirology. 17: 314-26. PMID 21671121 DOI: 10.1007/S13365-011-0038-1 |
0.318 |
|
| 2010 |
DeBiasi RL, Robinson BA, Leser JS, Brown RD, Long CS, Clarke P. Critical role for death-receptor mediated apoptotic signaling in viral myocarditis. Journal of Cardiac Failure. 16: 901-10. PMID 21055654 DOI: 10.1016/J.Cardfail.2010.05.030 |
0.425 |
|
| 2010 |
Tyler KL, Leser JS, Phang TL, Clarke P. Gene expression in the brain during reovirus encephalitis. Journal of Neurovirology. 16: 56-71. PMID 20158406 DOI: 10.3109/13550280903586394 |
0.494 |
|
| 2009 |
Clarke P, Beckham JD, Leser JS, Hoyt CC, Tyler KL. Fas-mediated apoptotic signaling in the mouse brain following reovirus infection. Journal of Virology. 83: 6161-70. PMID 19321603 DOI: 10.1128/Jvi.02488-08 |
0.49 |
|
| 2009 |
Clarke P, Tyler KL. Apoptosis in animal models of virus-induced disease. Nature Reviews. Microbiology. 7: 144-55. PMID 19148180 DOI: 10.1038/Nrmicro2071 |
0.455 |
|
| 2007 |
Beckham JD, Goody RJ, Clarke P, Bonny C, Tyler KL. Novel strategy for treatment of viral central nervous system infection by using a cell-permeating inhibitor of c-Jun N-terminal kinase. Journal of Virology. 81: 6984-92. PMID 17475657 DOI: 10.1128/Jvi.00467-07 |
0.515 |
|
| 2007 |
Clarke P, Tyler KL. Down-regulation of cFLIP following reovirus infection sensitizes human ovarian cancer cells to TRAIL-induced apoptosis. Apoptosis : An International Journal On Programmed Cell Death. 12: 211-23. PMID 17136319 DOI: 10.1007/S10495-006-0528-4 |
0.433 |
|
| 2005 |
Clarke P, Debiasi RL, Meintzer SM, Robinson BA, Tyler KL. Inhibition of NF-kappa B activity and cFLIP expression contribute to viral-induced apoptosis. Apoptosis : An International Journal On Programmed Cell Death. 10: 513-24. PMID 15909114 DOI: 10.1007/S10495-005-1881-4 |
0.452 |
|
| 2005 |
Clarke P, Debiasi RL, Goody R, Hoyt CC, Richardson-Burns S, Tyler KL. Mechanisms of reovirus-induced cell death and tissue injury: role of apoptosis and virus-induced perturbation of host-cell signaling and transcription factor activation. Viral Immunology. 18: 89-115. PMID 15802955 DOI: 10.1089/Vim.2005.18.89 |
0.508 |
|
| 2005 |
Clarke P, Richardson-Burns SM, DeBiasi RL, Tyler KL. Mechanisms of apoptosis during reovirus infection. Current Topics in Microbiology and Immunology. 289: 1-24. PMID 15791949 DOI: 10.1007/3-540-27320-4_1 |
0.512 |
|
| 2004 |
Clarke P, Meintzer SM, Wang Y, Moffitt LA, Richardson-Burns SM, Johnson GL, Tyler KL. JNK regulates the release of proapoptotic mitochondrial factors in reovirus-infected cells. Journal of Virology. 78: 13132-8. PMID 15542665 DOI: 10.1128/Jvi.78.23.13132-13138.2004 |
0.473 |
|
| 2004 |
Tyler KL, Barton ES, Ibach ML, Robinson C, Campbell JA, O'Donnell SM, Valyi-Nagy T, Clarke P, Wetzel JD, Dermody TS. Isolation and molecular characterization of a novel type 3 reovirus from a child with meningitis. The Journal of Infectious Diseases. 189: 1664-75. PMID 15116303 DOI: 10.1086/383129 |
0.387 |
|
| 2003 |
DeBiasi RL, Clarke P, Meintzer S, Jotte R, Kleinschmidt-Demasters BK, Johnson GL, Tyler KL. Reovirus-induced alteration in expression of apoptosis and DNA repair genes with potential roles in viral pathogenesis. Journal of Virology. 77: 8934-47. PMID 12885910 DOI: 10.1128/Jvi.77.16.8934-8947.2003 |
0.54 |
|
| 2003 |
Clarke P, Tyler KL. Reovirus-induced apoptosis: A minireview Apoptosis. 8: 141-150. PMID 12766474 DOI: 10.1023/A:1022966508671 |
0.505 |
|
| 2003 |
Clarke P, Meintzer SM, Moffitt LA, Tyler KL. Two distinct phases of virus-induced nuclear factor kappa B regulation enhance tumor necrosis factor-related apoptosis-inducing ligand-mediated apoptosis in virus-infected cells. The Journal of Biological Chemistry. 278: 18092-100. PMID 12637521 DOI: 10.1074/Jbc.M300265200 |
0.5 |
|
| 2002 |
Spalding AC, Jotte RM, Scheinman RI, Geraci MW, Clarke P, Tyler KL, Johnson GL. TRAIL and inhibitors of apoptosis are opposing determinants for NF-kappaB-dependent, genotoxin-induced apoptosis of cancer cells. Oncogene. 21: 260-71. PMID 11803469 DOI: 10.1038/Sj.Onc.1205048 |
0.371 |
|
| 2001 |
Tyler KL, Clarke P, DeBiasi RL, Kominsky D, Poggioli GJ. Reoviruses and the host cell. Trends in Microbiology. 9: 560-4. PMID 11825717 DOI: 10.1016/S0966-842X(01)02103-5 |
0.458 |
|
| 2001 |
Clarke P, Meintzer SM, Widmann C, Johnson GL, Tyler KL. Reovirus infection activates JNK and the JNK-dependent transcription factor c-Jun Journal of Virology. 75: 11275-11283. PMID 11689607 DOI: 10.1128/Jvi.75.23.11275-11283.2001 |
0.451 |
|
| 2001 |
Clarke P, Meintzer SM, Spalding AC, Johnson GL, Tyler KL. Caspase 8-dependent sensitization of cancer cells to TRAIL-induced apoptosis following reovirus-infection. Oncogene. 20: 6910-9. PMID 11687970 DOI: 10.1038/Sj.Onc.1204842 |
0.421 |
|
| 2000 |
Clarke P, Meintzer SM, Gibson S, Widmann C, Garrington TP, Johnson GL, Tyler KL. Reovirus-induced apoptosis is mediated by TRAIL Journal of Virology. 74: 8135-8139. PMID 10933724 DOI: 10.1128/Jvi.74.17.8135-8139.2000 |
0.442 |
|
| 2000 |
Yujiri T, Ware M, Widmann C, Oyer R, Russell D, Chan E, Zaitsu Y, Clarke P, Tyler K, Oka Y, Fanger GR, Henson P, Johnson GL. MEK kinase 1 gene disruption alters cell migration and c-Jun NH2-terminal kinase regulation but does not cause a measurable defect in NF-kappa B activation Proceedings of the National Academy of Sciences of the United States of America. 97: 7272-7277. PMID 10852963 DOI: 10.1073/Pnas.130176697 |
0.337 |
|
| 2000 |
Connolly JL, Rodgers SE, Clarke P, Ballard DW, Kerr LD, Tyler KL, Dermody TS. Reovirus-induced apoptosis requires activation of transcription factor NF-kappaB. Journal of Virology. 74: 2981-9. PMID 10708412 DOI: 10.1128/Jvi.74.7.2981-2989.2000 |
0.438 |
|
| 1996 |
Clarke P, Matlock WL, Beer T, Gilden DH. A simian varicella virus (SVV) homolog to varicella-zoster virus gene 21 is expressed in monkey ganglia latently infected with SVV Journal of Virology. 70: 5711-5715. PMID 8764094 DOI: 10.1128/Jvi.70.8.5711-5715.1996 |
0.591 |
|
| 1995 |
Clarke P, Beer T, Gilden DH. Configuration and terminal sequences of the simian varicella virus genome Virology. 207: 154-159. PMID 7871724 DOI: 10.1006/Viro.1995.1061 |
0.506 |
|
| 1995 |
Clarke P, Beer T, Cohrs R, Gilden DH. Configuration of latent Varicella-Zoster virus DNA Journal of Virology. 69: 8151-8154. PMID 7494340 DOI: 10.1128/Jvi.69.12.8151-8154.1995 |
0.547 |
|
| 1993 |
Clarke P, Brunschwig A, Gilden DH. DNA sequence of a simian varicella virus gene that encodes a homologue of varicella zoster virus IE62 and herpes simplex virus ICP4 Virology. 197: 45-52. PMID 8212583 DOI: 10.1006/Viro.1993.1565 |
0.598 |
|
| 1992 |
Clarke P, Rabkin SD, Inman MV, Mahalingam R, Cohrs R, Wellish M, Gilden DH. Molecular analysis of simian varicella virus DNA. Virology. 190: 597-605. PMID 1519354 DOI: 10.1016/0042-6822(92)90897-X |
0.544 |
|
| 1992 |
Mahalingam R, Clarke P, Wellish M, Dueland AN, Soike KF, Gilden DH, Cohrs R. Prevalence and distribution of latent simian varicella virus DNA in monkey ganglia Virology. 188: 193-197. PMID 1314451 DOI: 10.1016/0042-6822(92)90749-F |
0.569 |
|
| 1991 |
Clarke P, Clements JB. Mutagenesis occurring following infection with herpes simplex virus does not require virus replication. Virology. 182: 597-606. PMID 1850920 DOI: 10.1016/0042-6822(91)90600-G |
0.385 |
|
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