Utpal Das - Related publications

University of California, San Diego, La Jolla, CA 
Neuroscience, Cell Biology
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50 most relevant papers in past 60 days:
Year Citation  Score
2021 Chen XQ, Das U, Park G, Mobley WC. Normal levels of KIF5 but reduced KLC1 levels in both Alzheimer disease and Alzheimer disease in Down syndrome: evidence suggesting defects in anterograde transport. Alzheimer's Research & Therapy. 13: 59. PMID 33691783 DOI: 10.1186/s13195-021-00796-6   
2021 Cai T, Tomita T. Sequential conformational changes in transmembrane domains of presenilin 1 in Aβ42 downregulation. Journal of Biochemistry. PMID 33739423 DOI: 10.1093/jb/mvab033   
2021 Paulus A, Engdahl A, Yang Y, Boza-Serrano A, Bachiller S, Torres-Garcia L, Svanbergsson A, Garcia MG, Gouras GK, Li JY, Deierborg T, Klementieva O. Amyloid Structural Changes Studied by Infrared Microspectroscopy in Bigenic Cellular Models of Alzheimer's Disease. International Journal of Molecular Sciences. 22. PMID 33810433 DOI: 10.3390/ijms22073430   
2021 Brown A, Török M. Functional amyloids in the human body. Bioorganic & Medicinal Chemistry Letters. 127914. PMID 33691165 DOI: 10.1016/j.bmcl.2021.127914   
2021 Wong D, Broberg DN, Doad J, Umoh JU, Bellyou M, Norley CJD, Holdsworth D, Montero-Odasso M, Beauchet O, Annweiler C, Bartha R. Effect of Memantine Treatment and Combination with Vitamin D Supplementation on Body Composition in the APP/PS1 Mouse Model of Alzheimer's Disease Following Chronic Vitamin D Deficiency. Journal of Alzheimer's Disease : Jad. PMID 33780366 DOI: 10.3233/JAD-201137   
2021 Qu Y, Wang W, Chen T, Yang Y, Zhang Y, Wang D. The neuroprotection of deproteinized calf blood extractives injection against Alzheimer's disease via regulation of Nrf-2 signaling. Aging. 13. PMID 33819182 DOI: 10.18632/aging.202776   
2021 Miranda A, Montiel E, Ulrich H, Paz C. Selective Secretase Targeting for Alzheimer's Disease Therapy. Journal of Alzheimer's Disease : Jad. PMID 33749645 DOI: 10.3233/JAD-201027   
2021 Khan A, Das S, Sergi C. Therapeutic Potential of Neu1 in Alzheimer's Disease Via the Immune System. American Journal of Alzheimer's Disease and Other Dementias. 36: 1533317521996147. PMID 33719595 DOI: 10.1177/1533317521996147   
2021 Roca-Agujetas V, Barbero-Camps E, de Dios C, Podlesniy P, Abadin X, Morales A, Marí M, Trullàs R, Colell A. Cholesterol alters mitophagy by impairing optineurin recruitment and lysosomal clearance in Alzheimer's disease. Molecular Neurodegeneration. 16: 15. PMID 33685483 DOI: 10.1186/s13024-021-00435-6   
2021 Sharma S. Role of Extracellular vesicles in Alzheimer's disease: Current Advances. Current Molecular Medicine. PMID 33823777 DOI: 10.2174/1566524021666210406121807   
2021 Thompson TB, Meisl G, Knowles TPJ, Goriely A. The role of clearance mechanisms in the kinetics of pathological protein aggregation involved in neurodegenerative diseases. The Journal of Chemical Physics. 154: 125101. PMID 33810689 DOI: 10.1063/5.0031650   
2021 Yang J, Perrett S, Wu S. Single Molecule Characterization of Amyloid Oligomers. Molecules (Basel, Switzerland). 26. PMID 33670093 DOI: 10.3390/molecules26040948   
2021 Yoon JH, Lee N, Youn K, Jo MR, Kim HR, Lee DS, Ho CT, Jun M. Dieckol Ameliorates Aβ Production via PI3K/Akt/GSK-3β Regulated APP Processing in SweAPP N2a Cell. Marine Drugs. 19. PMID 33804171 DOI: 10.3390/md19030152   
2021 Nakamura M, Li Y, Choi BR, Matas-Rico E, Troncoso J, Takahashi C, Sockanathan S. GDE2-RECK controls ADAM10 α-secretase-mediated cleavage of amyloid precursor protein. Science Translational Medicine. 13. PMID 33731436 DOI: 10.1126/scitranslmed.abe6178   
2021 Jang M, Choi SH, Choi JH, Oh J, Lee RM, Lee NE, Cho YJ, Rhim H, Kim HC, Cho IH, Nah SY. Ginseng gintonin attenuates the disruptions of brain microvascular permeability and microvascular endothelium junctional proteins in an APPswe/PSEN-1 double-transgenic mouse model of Αlzheimer's disease. Experimental and Therapeutic Medicine. 21: 310. PMID 33717253 DOI: 10.3892/etm.2021.9741   
2021 Davis N, Mota BC, Stead L, Palmer EOC, Lombardero L, Rodríguez-Puertas R, de Paola V, Barnes SJ, Sastre M. Pharmacological ablation of astrocytes reduces Aβ degradation and synaptic connectivity in an ex vivo model of Alzheimer's disease. Journal of Neuroinflammation. 18: 73. PMID 33731156 DOI: 10.1186/s12974-021-02117-y   
2021 Deng Z, Wang J, Xiao Y, Li F, Niu L, Liu X, Meng L, Zheng H. Ultrasound-mediated augmented exosome release from astrocytes alleviates amyloid-β-induced neurotoxicity. Theranostics. 11: 4351-4362. PMID 33754065 DOI: 10.7150/thno.52436   
2021 Yoo JY, Kim HB, Baik TK, Lee JH, Woo RS. Neuregulin 1/ErbB4/Akt signaling attenuates cytotoxicity mediated by the APP-CT31 fragment of amyloid precursor protein. Experimental and Molecular Pathology. 104622. PMID 33684392 DOI: 10.1016/j.yexmp.2021.104622   
2021 Tosh JL, Rhymes ER, Mumford P, Whittaker HT, Pulford LJ, Noy SJ, Cleverley K, , Walker MC, Tybulewicz VLJ, Wykes RC, Fisher EMC, Wiseman FK. Genetic dissection of down syndrome-associated alterations in APP/amyloid-β biology using mouse models. Scientific Reports. 11: 5736. PMID 33707583 DOI: 10.1038/s41598-021-85062-3   
2021 Gaudreault R, Hervé V, van de Ven TGM, Mousseau N, Ramassamy C. Polyphenol-Peptide Interactions in Mitigation of Alzheimer's Disease: Role of Biosurface-Induced Aggregation. Journal of Alzheimer's Disease : Jad. PMID 33749653 DOI: 10.3233/JAD-201549   
2021 Stepanchuk AA, Heyne B, Stys PK. Complex Photophysical Properties of K114 Make for a Versatile Fluorescent Probe for Amyloid Detection. Acs Chemical Neuroscience. PMID 33705095 DOI: 10.1021/acschemneuro.1c00101   
2021 Husain MA, Laurent B, Plourde M. APOE and Alzheimer's Disease: From Lipid Transport to Physiopathology and Therapeutics. Frontiers in Neuroscience. 15: 630502. PMID 33679311 DOI: 10.3389/fnins.2021.630502   
2021 Choi J, Chung C, Woo H. Diet-Related Mobile Apps to Promote Healthy Eating and Proper Nutrition: A Content Analysis and Quality Assessment. International Journal of Environmental Research and Public Health. 18. PMID 33800531 DOI: 10.3390/ijerph18073496   
2021 Al-Thani HF, Ahmad MN, Younes S, Zayed H. Genetic Variants Associated With Alzheimer Disease in the 22 Arab Countries: A Systematic Review. Alzheimer Disease and Associated Disorders. PMID 33769987 DOI: 10.1097/WAD.0000000000000447   
2021 Nackenoff AG, Hohman TJ, Neuner SM, Akers CS, Weitzel NC, Shostak A, Ferguson SM, Mobley B, Bennett DA, Schneider JA, Jefferson AL, Kaczorowski CC, Schrag MS. PLD3 is a neuronal lysosomal phospholipase D associated with β-amyloid plaques and cognitive function in Alzheimer's disease. Plos Genetics. 17: e1009406. PMID 33830999 DOI: 10.1371/journal.pgen.1009406   
2021 Ni R, Röjdner J, Voytenko L, Dyrks T, Thiele A, Marutle A, Nordberg A. In vitro Characterization of the Regional Binding Distribution of Amyloid PET Tracer Florbetaben and the Glia Tracers Deprenyl and PK1195 in Autopsy Alzheimer's Brain Tissue. Journal of Alzheimer's Disease : Jad. PMID 33749648 DOI: 10.3233/JAD-201344   
2021 Zhang X, Li J, Ma L, Xu H, Cao Y, Liang W, Ma J, Wang ZP, Li Y. BMP4 overexpression induces the upregulation of APP/Tau and memory deficits in Alzheimer's disease. Cell Death Discovery. 7: 51. PMID 33723239 DOI: 10.1038/s41420-021-00435-x   
2021 Jiang N, Cupolillo D, Grosjean N, Muller E, Deforges S, Mulle C, Amédée T. Impaired plasticity of intrinsic excitability in the dentate gyrus alters spike transfer in a mouse model of Alzheimer's disease. Neurobiology of Disease. 105345. PMID 33766653 DOI: 10.1016/j.nbd.2021.105345   
2021 Suire CN, Leissring MA. Cathepsin D: A Candidate Link between Amyloid β-protein and Tauopathy in Alzheimer Disease. Journal of Experimental Neurology. 2: 10-15. PMID 33665647   
2021 Cash MK, Rockwood K, Fisk JD, Darvesh S. Clinicopathological correlations and cholinesterase expression in early-onset familial Alzheimer's disease with the presenilin 1 mutation, Leu235Pro. Neurobiology of Aging. 103: 31-41. PMID 33789210 DOI: 10.1016/j.neurobiolaging.2021.02.025   
2021 Jin L, Liu C, Zhang N, Zhang R, Yan M, Bhunia A, Zhang Q, Liu M, Han J, Siebert HC. Attenuation of Human Lysozyme Amyloid Fibrillation by ACE Inhibitor Captopril: A Combined Spectroscopy, Microscopy, Cytotoxicity, and Docking Study. Biomacromolecules. PMID 33844512 DOI: 10.1021/acs.biomac.0c01802   
2021 Wells C, Brennan S, Keon M, Ooi L. The role of amyloid oligomers in neurodegenerative pathologies. International Journal of Biological Macromolecules. PMID 33766600 DOI: 10.1016/j.ijbiomac.2021.03.113   
2021 Wang J, Liu B, Xu Y, Yang M, Wang C, Song M, Liu J, Wang W, You J, Sun F, Wang D, Liu D, Yan H. Activation of CREB-mediated autophagy by thioperamide ameliorates β-amyloid pathology and cognition in Alzheimer's disease. Aging Cell. e13333. PMID 33682314 DOI: 10.1111/acel.13333   
2021 Jang BG, Lee J, Choi B, Koh YH, Kim MJ. Unexpected beta-amyloid production by middle doses of resveratrol through stabilization of APP protein and AMPK-mediated inhibition of trypsin-like proteasome activity in a cell model of Alzheimer's disease. Food and Chemical Toxicology : An International Journal Published For the British Industrial Biological Research Association. 112185. PMID 33845068 DOI: 10.1016/j.fct.2021.112185   
2021 Yu H, Wu J. Amyloid-β: A double agent in Alzheimer's disease? Biomedicine & Pharmacotherapy = Biomedecine & Pharmacotherapie. 139: 111575. PMID 33845371 DOI: 10.1016/j.biopha.2021.111575   
2021 Tian DY, Cheng Y, Zhuang ZQ, He CY, Pan QG, Tang MZ, Hu XL, Shen YY, Wang YR, Chen SH, Sun HL, Sun PY, Yu ZY, Fan DY, Bu XL, et al. Physiological clearance of amyloid-beta by the kidney and its therapeutic potential for Alzheimer's disease. Molecular Psychiatry. PMID 33828237 DOI: 10.1038/s41380-021-01073-6   
2021 Shin J, Yang SH, Du YE, Park K, Kim D, Shin D, Kim J, Kim SH, Kim YK, Shin J, Oh DC, Kim Y. Borrelidin from Saltern-Derived Halophilic sp. Dissociates Amyloid- and Tau Fibrils. Journal of Alzheimer's Disease Reports. 5: 7-13. PMID 33681712 DOI: 10.3233/ADR-200247   
2021 Gao J, Suo C, Tseng JH, Moss MA, Terry AV, Chapman J. Design and Synthesis of Ranitidine Analogs as Multi-Target Directed Ligands for the Treatment of Alzheimer's Disease. International Journal of Molecular Sciences. 22. PMID 33803769 DOI: 10.3390/ijms22063120   
2021 Latina V, Giacovazzo G, Cordella F, Balzamino BO, Micera A, Varano M, Marchetti C, Malerba F, Florio R, Ercole BB, La Regina F, Atlante A, Coccurello R, Di Angelantonio S, Calissano P, et al. Systemic delivery of a specific antibody targeting the pathological N-terminal truncated tau peptide reduces retinal degeneration in a mouse model of Alzheimer's Disease. Acta Neuropathologica Communications. 9: 38. PMID 33750467 DOI: 10.1186/s40478-021-01138-1   
2021 Zhang X, Zhang CM, Prokopenko D, Liang Y, Zhen SY, Weigle IQ, Han W, Aryal M, Tanzi RE, Sisodia SS. An APP ectodomain mutation outside of the Aβ domain promotes Aβ production in vitro and deposition in vivo. The Journal of Experimental Medicine. 218. PMID 33822840 DOI: 10.1084/jem.20210313   
2021 Ahuja A, Tyagi PK, Tyagi S, Kumar A, Kumar M, Sharifi-Rad J. Potential of Pueraria tuberosa (Willd.) DC. to rescue cognitive decline associated with BACE1 protein of Alzheimer's disease on Drosophila model: An integrated molecular modeling and in vivo approach. International Journal of Biological Macromolecules. PMID 33705837 DOI: 10.1016/j.ijbiomac.2021.03.032   
2021 Su X, Tang Z, Lu Z, Liu Y, He W, Jiang J, Zhang Y, Wu H. Oral Treponema denticola Infection Induces Aβ and Aβ Accumulation in the Hippocampus of C57BL/6 Mice. Journal of Molecular Neuroscience : Mn. PMID 33763842 DOI: 10.1007/s12031-021-01827-5   
2021 Koriyama Y, Hori A, Ito H, Yonezawa S, Baba Y, Tanimoto N, Ueno T, Yamamoto S, Yamamoto T, Asada N, Morimoto K, Einaru S, Sakai K, Kanazu T, Matsuda A, et al. Discovery of Atabecestat (JNJ-54861911): A Thiazine-Based β-Amyloid Precursor Protein Cleaving Enzyme 1 Inhibitor Advanced to the Phase 2b/3 EARLY Clinical Trial. Journal of Medicinal Chemistry. 64: 1873-1888. PMID 33588527 DOI: 10.1021/acs.jmedchem.0c01917   
2021 Al-Shabib NA, Khan JM, Malik A, Rehman MT, Husain FM, AlAjmi MF, Hamdan Ali Alghamdi O, Khan A. Quinoline yellow dye stimulates whey protein fibrillation via electrostatic and hydrophobic interaction: A biophysical study. Journal of Dairy Science. PMID 33685710 DOI: 10.3168/jds.2020-19766   
2021 Al-Shabib NA, Khan JM, Malik A, Rehman MT, Husain FM, AlAjmi MF, Hamdan Ali Alghamdi O, Khan A. Quinoline yellow dye stimulates whey protein fibrillation via electrostatic and hydrophobic interaction: A biophysical study. Journal of Dairy Science. PMID 33685710 DOI: 10.3168/jds.2020-19766   
2021 Nuebling GS, Prix C, Brendel M, Beyer L, Wlasich E, Loosli SV, Barthel H, Sabri O, Bartenstein P, Vöglein J, Danek A, Rominger A, Edbauer D, Haass C, Levin J. Low-degree trisomy 21 mosaicism promotes early-onset Alzheimer disease. Neurobiology of Aging. PMID 33789815 DOI: 10.1016/j.neurobiolaging.2021.02.021   
2021 Csincsik L, Nelson R, Walpert MJ, Peto T, Holland A, Lengyel I. Increased choroidal thickness in adults with Down syndrome. Alzheimer's & Dementia (Amsterdam, Netherlands). 13: e12170. PMID 33748396 DOI: 10.1002/dad2.12170   
2021 Qiao A, Li J, Hu Y, Wang J, Zhao Z. Reduction BACE1 expression via suppressing NF-κB mediated signaling by Tamibarotene in a mouse model of Alzheimer's disease. Ibro Neuroscience Reports. 10: 153-160. PMID 33842919 DOI: 10.1016/j.ibneur.2021.02.004   
2021 Yanagisawa D, Ibrahim NF, Taguchi H, Morikawa S, Tomiyama T, Tooyama I. Fluorine-19 Magnetic Resonance Imaging for Detection of Amyloid β Oligomers Using a Keto Form of Curcumin Derivative in a Mouse Model of Alzheimer's Disease. Molecules (Basel, Switzerland). 26. PMID 33806326 DOI: 10.3390/molecules26051362   
2021 Muvva C, Murugan NA, Subramanian V. Assessment of Amyloid Forming Tendency of Peptide Sequences from Amyloid Beta and Tau Proteins Using Force-Field, Semi-Empirical, and Density Functional Theory Calculations. International Journal of Molecular Sciences. 22. PMID 33806726 DOI: 10.3390/ijms22063244