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Douglas M. Fowler, Ph.D. - Publications

Affiliations: 
Genome Sciences University of Washington, Seattle, Seattle, WA 
Area:
Chemical Biology
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37 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2020 Chiasson MA, Rollins NJ, Stephany JJ, Sitko KA, Matreyek KA, Verby M, Sun S, Roth FP, DeSloover D, Marks DS, Rettie AE, Fowler DM. Multiplexed measurement of variant abundance and activity reveals VKOR topology, active site and human variant impact. Elife. 9. PMID 32870157 DOI: 10.7554/Elife.58026  0.318
2020 Potter ZE, Lau HT, Chakraborty S, Fang L, Guttman M, Ong SE, Fowler DM, Maly DJ. Parallel Chemoselective Profiling for Mapping Protein Structure. Cell Chemical Biology. PMID 32649906 DOI: 10.1016/J.Chembiol.2020.06.014  0.304
2020 Chen JZ, Fowler DM, Tokuriki N. Comprehensive exploration of the translocation, stability and substrate recognition requirements in VIM-2 lactamase. Elife. 9. PMID 32510322 DOI: 10.7554/Elife.56707  0.31
2020 Chao JT, Hollman R, Meyers WM, Meili F, Matreyek KA, Dean P, Fowler DM, Haas K, Roskelley CD, Loewen CJR. A premalignant cell-based model for functionalization and classification of PTEN variants. Cancer Research. PMID 32366478 DOI: 10.1158/0008-5472.Can-19-3278  0.345
2020 Suiter CC, Moriyama T, Matreyek KA, Yang W, Scaletti ER, Nishii R, Yang W, Hoshitsuki K, Singh M, Trehan A, Parish C, Smith C, Li L, Bhojwani D, Yuen LYP, ... ... Fowler DM, et al. Massively parallel variant characterization identifies alleles associated with thiopurine toxicity. Proceedings of the National Academy of Sciences of the United States of America. PMID 32094176 DOI: 10.1073/Pnas.1915680117  0.357
2020 Dines JN, Shirts BH, Slavin TP, Walsh T, King MC, Fowler DM, Pritchard CC. Systematic misclassification of missense variants in BRCA1 and BRCA2 "coldspots". Genetics in Medicine : Official Journal of the American College of Medical Genetics. PMID 31911673 DOI: 10.1038/S41436-019-0740-6  0.304
2019 Gelman H, Dines JN, Berg J, Berger AH, Brnich S, Hisama FM, James RG, Rubin AF, Shendure J, Shirts B, Fowler DM, Starita LM. Recommendations for the collection and use of multiplexed functional data for clinical variant interpretation. Genome Medicine. 11: 85. PMID 31862013 DOI: 10.1186/S13073-019-0698-7  0.308
2019 Matreyek KA, Stephany JJ, Chiasson MA, Hasle N, Fowler DM. An improved platform for functional assessment of large protein libraries in mammalian cells. Nucleic Acids Research. PMID 31612958 DOI: 10.1093/Nar/Gkz910  0.302
2019 Gray VE, Sitko K, Kameni FZN, Williamson M, Stephany JJ, Hasle N, Fowler DM. Elucidating the Molecular Determinants of Αβ Aggregation with Deep Mutational Scanning. G3 (Bethesda, Md.). PMID 31558564 DOI: 10.1534/G3.119.400535  0.356
2019 Dalton R, Lee SB, Claw KG, Prasad B, Phillips BR, Shen DD, Hong Wong L, Fade M, McDonald MG, Dunham MJ, Fowler DM, Rettie AE, Schuetz E, Thornton TA, Nickerson DA, et al. Interrogation of CYP2D6 structural variant alleles improves the correlation between CYP2D6 genotype and CYP2D6-mediated metabolic activity. Clinical and Translational Science. PMID 31536170 DOI: 10.1111/Cts.12695  0.316
2019 Hasle N, Matreyek KA, Fowler DM. The Impact of Genetic Variants on Molecular Functions and Cellular Phenotypes. Cold Spring Harbor Perspectives in Medicine. PMID 31451538 DOI: 10.1101/Cshperspect.A036228  0.369
2019 Stein A, Fowler DM, Hartmann-Petersen R, Lindorff-Larsen K. Biophysical and Mechanistic Models for Disease-Causing Protein Variants. Trends in Biochemical Sciences. PMID 30712981 DOI: 10.1016/J.Tibs.2019.01.003  0.346
2018 Matreyek KA, Starita LM, Stephany JJ, Martin B, Chiasson MA, Gray VE, Kircher M, Khechaduri A, Dines JN, Hause RJ, Bhatia S, Evans WE, Relling MV, Yang W, Shendure J, ... Fowler DM, et al. Multiplex assessment of protein variant abundance by massively parallel sequencing. Nature Genetics. PMID 29785012 DOI: 10.1038/S41588-018-0122-Z  0.355
2017 Weile J, Sun S, Cote AG, Knapp J, Verby M, Mellor JC, Wu Y, Pons C, Wong C, van Lieshout N, Yang F, Tasan M, Tan G, Yang S, Fowler DM, et al. A framework for exhaustively mapping functional missense variants. Molecular Systems Biology. 13: 957. PMID 29269382 DOI: 10.15252/Msb.20177908  0.335
2017 Starita LM, Ahituv N, Dunham MJ, Kitzman JO, Roth FP, Seelig G, Shendure J, Fowler DM. Variant Interpretation: Functional Assays to the Rescue. American Journal of Human Genetics. 101: 315-325. PMID 28886340 DOI: 10.1016/J.Ajhg.2017.07.014  0.332
2017 Gray VE, Hause RJ, Fowler DM. Analysis of Large-Scale Mutagenesis Data To Assess the Impact of Single Amino Acid Substitutions. Genetics. PMID 28751422 DOI: 10.1534/Genetics.117.300064  0.301
2017 Manolio TA, Fowler DM, Starita LM, Haendel MA, MacArthur DG, Biesecker LG, Worthey E, Chisholm RL, Green ED, Jacob HJ, McLeod HL, Roden D, Rodriguez LL, Williams MS, Cooper GM, et al. Bedside Back to Bench: Building Bridges between Basic and Clinical Genomic Research. Cell. 169: 6-12. PMID 28340351 DOI: 10.1016/J.Cell.2017.03.005  0.303
2017 Matreyek KA, Stephany JJ, Fowler DM. A platform for functional assessment of large variant libraries in mammalian cells. Nucleic Acids Research. PMID 28335006 DOI: 10.1093/Nar/Gkx183  0.319
2015 Jin Z, Di Rienzi SC, Janzon A, Werner JJ, Angenent LT, Dangl JL, Fowler DM, Ley RE. Novel rhizosphere soil alleles for the enzyme ACC deaminase queried functionally with an in-vivo competition assay. Applied and Environmental Microbiology. PMID 26637602 DOI: 10.1128/Aem.03074-15  0.312
2015 Starita LM, Young DL, Islam M, Kitzman JO, Gullingsrud J, Hause RJ, Fowler DM, Parvin JD, Shendure J, Fields S. Massively Parallel Functional Analysis of BRCA1 RING Domain Variants. Genetics. 200: 413-22. PMID 25823446 DOI: 10.1534/Genetics.115.175802  0.308
2014 Fowler DM, Stephany JJ, Fields S. Measuring the activity of protein variants on a large scale using deep mutational scanning. Nature Protocols. 9: 2267-84. PMID 25167058 DOI: 10.1038/Nprot.2014.153  0.345
2014 Fowler DM, Fields S. Deep mutational scanning: a new style of protein science. Nature Methods. 11: 801-7. PMID 25075907 DOI: 10.1038/Nmeth.3027  0.342
2013 Gold MG, Fowler DM, Means CK, Pawson CT, Stephany JJ, Langeberg LK, Fields S, Scott JD. Engineering A-kinase anchoring protein (AKAP)-selective regulatory subunits of protein kinase A (PKA) through structure-based phage selection. The Journal of Biological Chemistry. 288: 17111-21. PMID 23625929 DOI: 10.1074/Jbc.M112.447326  0.303
2012 Fowler DM, Kelly JW. Functional amyloidogenesis and cytotoxicity-insights into biology and pathology. Plos Biology. 10: e1001459. PMID 23300381 DOI: 10.1371/Journal.Pbio.1001459  0.497
2012 Araya CL, Fowler DM, Chen W, Muniez I, Kelly JW, Fields S. A fundamental protein property, thermodynamic stability, revealed solely from large-scale measurements of protein function. Proceedings of the National Academy of Sciences of the United States of America. 109: 16858-63. PMID 23035249 DOI: 10.1073/Pnas.1209751109  0.631
2012 Fowler DM, Koulov AV, Kelly JW, Balch WE. Mammalian functional amyloid The Functional Fold: Amyloid Structures in Nature. 147-158. DOI: 10.4032/9789814267625  0.42
2011 Fowler DM, Araya CL, Gerard W, Fields S. Enrich: software for analysis of protein function by enrichment and depletion of variants. Bioinformatics (Oxford, England). 27: 3430-1. PMID 22006916 DOI: 10.1093/Bioinformatics/Btr577  0.344
2011 Araya CL, Fowler DM. Deep mutational scanning: assessing protein function on a massive scale. Trends in Biotechnology. 29: 435-42. PMID 21561674 DOI: 10.1016/J.Tibtech.2011.04.003  0.353
2010 Fowler DM, Araya CL, Fleishman SJ, Kellogg EH, Stephany JJ, Baker D, Fields S. High-resolution mapping of protein sequence-function relationships. Nature Methods. 7: 741-6. PMID 20711194 DOI: 10.1038/Nmeth.1492  0.347
2009 Watt B, van Niel G, Fowler DM, Hurbain I, Luk KC, Stayrook SE, Lemmon MA, Raposo G, Shorter J, Kelly JW, Marks MS. N-terminal domains elicit formation of functional Pmel17 amyloid fibrils. The Journal of Biological Chemistry. 284: 35543-55. PMID 19840945 DOI: 10.1074/Jbc.M109.047449  0.501
2009 Fowler DM, Kelly JW. Aggregating knowledge about prions and amyloid. Cell. 137: 20-2. PMID 19345180 DOI: 10.1016/J.Cell.2009.03.030  0.495
2008 Mu TW, Fowler DM, Kelly JW. Partial restoration of mutant enzyme homeostasis in three distinct lysosomal storage disease cell lines by altering calcium homeostasis. Plos Biology. 6: e26. PMID 18254660 DOI: 10.1371/Journal.Pbio.0060026  0.604
2007 Münch J, Rücker E, Ständker L, Adermann K, Goffinet C, Schindler M, Wildum S, Chinnadurai R, Rajan D, Specht A, Giménez-Gallego G, Sánchez PC, Fowler DM, Koulov A, Kelly JW, et al. Semen-derived amyloid fibrils drastically enhance HIV infection. Cell. 131: 1059-71. PMID 18083097 DOI: 10.1016/J.Cell.2007.10.014  0.428
2007 Fowler DM, Koulov AV, Balch WE, Kelly JW. Functional amyloid--from bacteria to humans. Trends in Biochemical Sciences. 32: 217-24. PMID 17412596 DOI: 10.1016/J.Tibs.2007.03.003  0.509
2006 Bosco DA, Fowler DM, Zhang Q, Nieva J, Powers ET, Wentworth P, Lerner RA, Kelly JW. Elevated levels of oxidized cholesterol metabolites in Lewy body disease brains accelerate alpha-synuclein fibrilization. Nature Chemical Biology. 2: 249-53. PMID 16565714 DOI: 10.1038/Nchembio782  0.673
2006 Fowler DM, Koulov AV, Alory-Jost C, Marks MS, Balch WE, Kelly JW. Functional amyloid formation within mammalian tissue. Plos Biology. 4: e6. PMID 16300414 DOI: 10.1371/Journal.Pbio.0040006  0.541
2006 Bosco DA, Fowler DM, Zhang Q, Nieva J, Powers ET, Wentworth P, Lerner RA, Kelly JW. Correction: Corrigendum: Elevated levels of oxidized cholesterol metabolites in Lewy body disease brains accelerate α-synuclein fibrilization Nature Chemical Biology. 2: 346-346. DOI: 10.1038/Nchembio0606-346B  0.673
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