| Year |
Citation |
Score |
| 2024 |
Xiao M, Dhungel S, Azad R, Favaro DC, Rajesh RP, Gardner KH, Kikani CK. Signal-regulated Unmasking of Nuclear Localization Motif in the PAS Domain Regulates the Nuclear Translocation of PASK. Journal of Molecular Biology. 168433. PMID 38182104 DOI: 10.1016/j.jmb.2023.168433 |
0.339 |
|
| 2023 |
Xu X, Marcelino LP, Favaro DC, Silvestrini ML, Solazzo R, Chong LT, Gardner KH. Identification of Small Molecule Ligand Binding Sites On and In the ARNT PAS-B Domain. Biorxiv : the Preprint Server For Biology. PMID 37961463 DOI: 10.1101/2023.11.03.565595 |
0.686 |
|
| 2023 |
Xiao M, Dhungel S, Azad R, Favaro D, Rajesh RP, Gardner KH, Kikani CK. Signal-regulated unmasking of the nuclear localization motif in the PAS domain regulates the nuclear translocation of PASK. Biorxiv : the Preprint Server For Biology. PMID 37732199 DOI: 10.1101/2023.09.06.556462 |
0.342 |
|
| 2023 |
Dikiy I, Swingle D, Toy K, Edupuganti UR, Rivera-Cancel G, Gardner KH. Diversity of function and higher-order structure within HWE sensor histidine kinases. The Journal of Biological Chemistry. 104934. PMID 37331599 DOI: 10.1016/j.jbc.2023.104934 |
0.774 |
|
| 2022 |
Berlew EE, Yamada K, Kuznetsov IA, Rand EA, Ochs CC, Jaber Z, Gardner KH, Chow BY. Designing Single-Component Optogenetic Membrane Recruitment Systems: The Rho-Family GTPase Signaling Toolbox. Acs Synthetic Biology. 11: 515-521. PMID 34978789 DOI: 10.1021/acssynbio.1c00604 |
0.793 |
|
| 2021 |
Xu X, Dikiy I, Evans MR, Marcelino LP, Gardner KH. Fragile protein folds: Sequence and environmental factors affecting the equilibrium of two interconverting, stably folded protein conformations. Magnetic Resonance (Gottingen, Germany). 2: 63-76. PMID 35603043 DOI: 10.5194/mr-2-63-2021 |
0.82 |
|
| 2021 |
Siclari JJ, Gardner KH. Two steps, one ligand: How PPARγ binds small-molecule agonists. Structure (London, England : 1993). 29: 935-936. PMID 34478635 DOI: 10.1016/j.str.2021.08.005 |
0.766 |
|
| 2021 |
Hart JE, Gardner KH. Lighting the way: Recent insights into the structure and regulation of phototropin blue light receptors. The Journal of Biological Chemistry. 100594. PMID 33781746 DOI: 10.1016/j.jbc.2021.100594 |
0.816 |
|
| 2021 |
LaBelle J, Ramos-Martinez A, Shen K, Motta-Mena LB, Gardner KH, Materna SC, Woo S. TAEL 2.0: An Improved Optogenetic Expression System for Zebrafish. Zebrafish. 20-28. PMID 33555975 DOI: 10.1089/zeb.2020.1951 |
0.782 |
|
| 2021 |
Xu X, Gagné D, Aramini JM, Gardner KH. Volume and Compressibility Differences Between Protein Conformations Revealed by High-Pressure NMR. Biophysical Journal. PMID 33524371 DOI: 10.1016/j.bpj.2020.12.034 |
0.785 |
|
| 2020 |
Iuliano JN, Tolentino Collado J, Gil AA, Ravindran PT, Lukacs A, Shin S, Woroniecka HA, Adamczyk K, Aramini JM, Edupuganti UR, Hall CR, Greetham GM, Sazanovich IV, Clark IP, Daryaee T, ... ... Gardner KH, et al. Unraveling the Mechanism of a LOV Domain Optogenetic Sensor: A Glutamine Lever Induces Unfolding of the Jα Helix. Acs Chemical Biology. PMID 32880430 DOI: 10.1021/Acschembio.0C00543 |
0.82 |
|
| 2020 |
Gardner KH. Decision letter: Multi-state recognition pathway of the intrinsically disordered protein kinase inhibitor by protein kinase A Elife. DOI: 10.7554/Elife.55607.Sa1 |
0.309 |
|
| 2019 |
Dikiy I, Gardner KH. Shining light on the alphaproteobacterial general stress response: Comment on: Fiebig et al., Mol Microbiol, 2019. Molecular Microbiology. PMID 31120626 DOI: 10.1111/Mmi.14311 |
0.674 |
|
| 2019 |
Dikiy I, Edupuganti UR, Abzalimov RR, Borbat PP, Srivastava M, Freed JH, Gardner KH. Insights into histidine kinase activation mechanisms from the monomeric blue light sensor EL346. Proceedings of the National Academy of Sciences of the United States of America. PMID 30808807 DOI: 10.1073/Pnas.1813586116 |
0.814 |
|
| 2019 |
Dikiy I, Clark LD, Gardner KH, Rosenbaum DM. Isotopic Labeling of Eukaryotic Membrane Proteins for NMR Studies of Interactions and Dynamics. Methods in Enzymology. 614: 37-65. PMID 30611431 DOI: 10.1016/Bs.Mie.2018.08.030 |
0.704 |
|
| 2018 |
Clark L, Dikiy I, Rosenbaum DM, Gardner KH. On the use of Pichia pastoris for isotopic labeling of human GPCRs for NMR studies. Journal of Biomolecular Nmr. PMID 30121871 DOI: 10.1007/S10858-018-0204-3 |
0.705 |
|
| 2018 |
Glantz ST, Berlew EE, Jaber Z, Schuster BS, Gardner KH, Chow BY. Directly light-regulated binding of RGS-LOV photoreceptors to anionic membrane phospholipids. Proceedings of the National Academy of Sciences of the United States of America. PMID 30065115 DOI: 10.1073/Pnas.1802832115 |
0.81 |
|
| 2018 |
Losi A, Gardner KH, Möglich A. Blue-Light Receptors for Optogenetics. Chemical Reviews. PMID 29984995 DOI: 10.1021/Acs.Chemrev.8B00163 |
0.364 |
|
| 2017 |
Clark LD, Dikiy I, Chapman K, Rödström KEJ, Aramini J, LeVine MV, Khelashvili G, Rasmussen SGF, Gardner KH, Rosenbaum DM. Ligand modulation of sidechain dynamics in a wild-type human GPCR. Elife. 6. PMID 28984574 DOI: 10.1016/J.Bpj.2017.11.1330 |
0.705 |
|
| 2017 |
Clark LD, Dikiy I, Chapman K, Rödström KE, Aramini J, LeVine MV, Khelashvili G, Rasmussen SG, Gardner KH, Rosenbaum DM. Author response: Ligand modulation of sidechain dynamics in a wild-type human GPCR Elife. DOI: 10.7554/Elife.28505.028 |
0.65 |
|
| 2016 |
Reade A, Motta-Mena LB, Gardner KH, Stainier DY, Weiner OD, Woo S. TAEL: A zebrafish-optimized optogenetic gene expression system with fine spatial and temporal control. Development (Cambridge, England). PMID 27993986 DOI: 10.1242/Dev.139238 |
0.773 |
|
| 2016 |
Corrêa F, Key J, Kuhlman B, Gardner KH. Computational Repacking of HIF-2α Cavity Replaces Water-Based Stabilized Core. Structure (London, England : 1993). PMID 27667693 DOI: 10.1016/J.Str.2016.08.014 |
0.737 |
|
| 2016 |
Corrêa F, Gardner KH. Basis of Mutual Domain Inhibition in a Bacterial Response Regulator. Cell Chemical Biology. PMID 27524295 DOI: 10.1016/J.Chembiol.2016.07.010 |
0.677 |
|
| 2016 |
Glantz ST, Carpenter EJ, Melkonian M, Gardner KH, Boyden ES, Wong GK, Chow BY. Functional and topological diversity of LOV domain photoreceptors. Proceedings of the National Academy of Sciences of the United States of America. PMID 26929367 DOI: 10.1073/Pnas.1509428113 |
0.445 |
|
| 2016 |
Clark L, Zahm JA, Ali R, Kukula M, Bian L, Patrie SM, Gardner KH, Rosen MK, Rosenbaum DM. Erratum to: Methyl labeling and TROSY NMR spectroscopy of proteins expressed in the eukaryote Pichia pastoris. Journal of Biomolecular Nmr. PMID 26894386 DOI: 10.1007/S10858-016-0016-2 |
0.478 |
|
| 2015 |
Scheuermann TH, Padrick SB, Gardner KH, Brautigam CA. On the acquisition and analysis of microscale thermophoresis data. Analytical Biochemistry. PMID 26739938 DOI: 10.1016/J.Ab.2015.12.013 |
0.792 |
|
| 2015 |
Scheuermann TH, Stroud D, Sleet CE, Bayeh L, Shokri C, Wang H, Caldwell CG, Longgood J, MacMillan JB, Bruick RK, Gardner KH, Tambar UK. Isoform-Selective and Stereoselective Inhibition of Hypoxia Inducible Factor-2. Journal of Medicinal Chemistry. PMID 26226049 DOI: 10.1021/Acs.Jmedchem.5B00529 |
0.813 |
|
| 2015 |
Clark L, Zahm JA, Ali R, Kukula M, Bian L, Patrie SM, Gardner KH, Rosen MK, Rosenbaum DM. Methyl labeling and TROSY NMR spectroscopy of proteins expressed in the eukaryote Pichia pastoris. Journal of Biomolecular Nmr. 62: 239-45. PMID 26025061 DOI: 10.1007/S10858-015-9939-2 |
0.567 |
|
| 2015 |
Ocasio VJ, Corrêa F, Gardner KH. Ligand-induced folding of a two-component signaling receiver domain. Biochemistry. 54: 1353-63. PMID 25629646 DOI: 10.1021/Bi501143B |
0.479 |
|
| 2015 |
Guo Y, Scheuermann TH, Partch CL, Tomchick DR, Gardner KH. Coiled-coil coactivators play a structural role mediating interactions in hypoxia-inducible factor heterodimerization. The Journal of Biological Chemistry. 290: 7707-21. PMID 25627682 DOI: 10.1074/Jbc.M114.632786 |
0.816 |
|
| 2014 |
Rivera-Cancel G, Ko WH, Tomchick DR, Correa F, Gardner KH. Full-length structure of a monomeric histidine kinase reveals basis for sensory regulation. Proceedings of the National Academy of Sciences of the United States of America. 111: 17839-44. PMID 25468971 DOI: 10.1073/Pnas.1413983111 |
0.818 |
|
| 2014 |
Motta-Mena LB, Reade A, Mallory MJ, Glantz S, Weiner OD, Lynch KW, Gardner KH. An optogenetic gene expression system with rapid activation and deactivation kinetics Nature Chemical Biology. 10: 196-202. PMID 24413462 DOI: 10.1038/Nchembio.1430 |
0.801 |
|
| 2013 |
Salomon D, Guo Y, Kinch LN, Grishin NV, Gardner KH, Orth K. Effectors of animal and plant pathogens use a common domain to bind host phosphoinositides. Nature Communications. 4: 2973. PMID 24346350 DOI: 10.1038/Ncomms3973 |
0.725 |
|
| 2013 |
Zoltowski BD, Motta-Mena LB, Gardner KH. Blue light-induced dimerization of a bacterial LOV-HTH DNA-binding protein Biochemistry. 52: 6653-6661. PMID 23992349 DOI: 10.1021/Bi401040M |
0.813 |
|
| 2013 |
Correa F, Ko WH, Ocasio V, Bogomolni RA, Gardner KH. Blue light regulated two-component systems: Enzymatic and functional analyses of light-oxygen-voltage (LOV)-histidine kinases and downstream response regulators Biochemistry. 52: 4656-4666. PMID 23806044 DOI: 10.1021/Bi400617Y |
0.779 |
|
| 2013 |
Scheuermann TH, Li Q, Ma HW, Key J, Zhang L, Chen R, Garcia JA, Naidoo J, Longgood J, Frantz DE, Tambar UK, Gardner KH, Bruick RK. Allosteric inhibition of hypoxia inducible factor-2 with small molecules. Nature Chemical Biology. 9: 271-6. PMID 23434853 DOI: 10.1038/Nchembio.1185 |
0.805 |
|
| 2013 |
Freddolino PL, Gardner KH, Schulten K. Signaling mechanisms of LOV domains: new insights from molecular dynamics studies. Photochemical & Photobiological Sciences : Official Journal of the European Photochemistry Association and the European Society For Photobiology. 12: 1158-70. PMID 23407663 DOI: 10.1039/C3Pp25400C |
0.498 |
|
| 2013 |
Moon TM, Correa F, Kinch LN, Piala AT, Gardner KH, Goldsmith EJ. Solution structure of the WNK1 autoinhibitory domain, a WNK-specific PF2 domain Journal of Molecular Biology. 425: 1245-1252. PMID 23376100 DOI: 10.1016/J.Jmb.2013.01.031 |
0.656 |
|
| 2013 |
Rogers JL, Bayeh L, Scheuermann TH, Longgood J, Key J, Naidoo J, Melito L, Shokri C, Frantz DE, Bruick RK, Gardner KH, MacMillan JB, Tambar UK. Development of inhibitors of the PAS-B domain of the HIF-2α transcription factor. Journal of Medicinal Chemistry. 56: 1739-47. PMID 23363003 DOI: 10.1021/Jm301847Z |
0.815 |
|
| 2013 |
Guo Y, Partch CL, Key J, Card PB, Pashkov V, Patel A, Bruick RK, Wurdak H, Gardner KH. Regulating the ARNT/TACC3 axis: multiple approaches to manipulating protein/protein interactions with small molecules. Acs Chemical Biology. 8: 626-35. PMID 23240775 DOI: 10.1021/Cb300604U |
0.805 |
|
| 2012 |
Rivera-Cancel G, Motta-Mena LB, Gardner KH. Identification of natural and artificial DNA substrates for light-activated LOV-HTH transcription factor EL222 Biochemistry. 51: 10024-10034. PMID 23205774 DOI: 10.1021/Bi301306T |
0.826 |
|
| 2012 |
Markley JL, Akutsu H, Asakura T, Baldus M, Boelens R, Bonvin A, Kaptein R, Bax A, Bezsonova I, Gryk MR, Hoch JC, Korzhnev DM, Maciejewski MW, Case D, Chazin WJ, ... ... Gardner K, et al. In support of the BMRB. Nature Structural & Molecular Biology. 19: 854-60. PMID 22955930 DOI: 10.1038/Nsmb.2371 |
0.692 |
|
| 2012 |
Moiola C, De Luca P, Cotignola J, Gardner K, Vazquez E, De Siervi A. Dynamic coregulatory complex containing BRCA1, E2F1 and CtIP controls ATM transcription. Cellular Physiology and Biochemistry : International Journal of Experimental Cellular Physiology, Biochemistry, and Pharmacology. 30: 596-608. PMID 22832221 DOI: 10.1159/000341441 |
0.361 |
|
| 2012 |
Rizo J, Rosen MK, Gardner KH. Enlightening molecular mechanisms through study of protein interactions Journal of Molecular Cell Biology. 4: 270-283. PMID 22735643 DOI: 10.1093/Jmcb/Mjs036 |
0.582 |
|
| 2012 |
Chollangi S, Thompson JW, Ruiz JC, Gardner KH, Bruick RK. Hemerythrin-like domain within F-box and leucine-rich repeat protein 5 (FBXL5) communicates cellular iron and oxygen availability by distinct mechanisms. The Journal of Biological Chemistry. 287: 23710-7. PMID 22648410 DOI: 10.1074/Jbc.M112.360404 |
0.335 |
|
| 2012 |
Gardner KH, Correa F. How plants see the invisible Science. 335: 1451-1452. PMID 22442470 DOI: 10.1126/Science.1220248 |
0.591 |
|
| 2012 |
Moon T, Correa F, Gardner K, Goldsmith E. Solution Structure of the WNK1 Autoinhibitory Domain Journal of Back and Musculoskeletal Rehabilitation. DOI: 10.2210/Pdb2Lru/Pdb |
0.603 |
|
| 2012 |
Nash AI, McNulty R, Shillito ME, Swartz TE, Bogomolni RA, Luecke H, Gardner KH. Structural basis of photosensitivity in a bacterial light-oxygen-voltage/ helix-turn-helix (LOV-HTH) DNA-binding protein (Proceedings of the National Academy of Sciences of the United States of America (2011) 108, 23 (9449-9454) DOI: 10.1073/pnas.1100262108) Proceedings of the National Academy of Sciences of the United States of America. 109: 5904. DOI: 10.1073/Pnas.1204100109 |
0.764 |
|
| 2012 |
Gardner KH, Motta-Mena LB, Zoltowski BD. Biophysical Studies of Natural Photoreceptors: Application to Optogenetic Tool Optimization Biophysical Journal. 102: 40a-41a. DOI: 10.1016/J.Bpj.2011.11.251 |
0.83 |
|
| 2011 |
Gardner KH, Mittermaier A, Mulder FAA. Special issue as a tribute to Lewis E Kay on his 50th birthday. Journal of Biomolecular Nmr. 51: 3-207. PMID 21947910 DOI: 10.1007/S10858-011-9561-X |
0.644 |
|
| 2011 |
Zoltowski BD, Nash AI, Gardner KH. Variations in protein-flavin hydrogen bonding in a light, oxygen, voltage domain produce non-Arrhenius kinetics of adduct decay. Biochemistry. 50: 8771-9. PMID 21923139 DOI: 10.1021/Bi200976A |
0.828 |
|
| 2011 |
Yuan H, Dragnea V, Wu Q, Gardner KH, Bauer CE. Mutational and structural studies of the PixD BLUF output signal that affects light-regulated interactions with PixE Biochemistry. 50: 6365-6375. PMID 21688827 DOI: 10.1021/Bi200701D |
0.443 |
|
| 2011 |
Nash AI, McNulty R, Shillito ME, Swartz TE, Bogomolni RA, Luecke H, Gardner KH. Structural basis of photosensitivity in a bacterial light-oxygen-voltage/helix-turn-helix (LOV-HTH) DNA-binding protein. Proceedings of the National Academy of Sciences of the United States of America. 108: 9449-54. PMID 21606338 DOI: 10.1073/Pnas.1100262108 |
0.81 |
|
| 2011 |
Partch CL, Gardner KH. Coactivators necessary for transcriptional output of the hypoxia inducible factor, HIF, are directly recruited by ARNT PAS-B. Proceedings of the National Academy of Sciences of the United States of America. 108: 7739-44. PMID 21512126 DOI: 10.1073/Pnas.1101357108 |
0.717 |
|
| 2011 |
Song SH, Freddolino PL, Nash AI, Carroll EC, Schulten K, Gardner KH, Larsen DS. Modulating LOV domain photodynamics with a residue alteration outside the chromophore binding site. Biochemistry. 50: 2411-23. PMID 21323358 DOI: 10.1021/Bi200198X |
0.803 |
|
| 2011 |
Zoltowski BD, Gardner KH. Tripping the light fantastic: Blue-light photoreceptors as examples of environmentally modulated protein-protein interactions Biochemistry. 50: 4-16. PMID 21141905 DOI: 10.1021/Bi101665S |
0.72 |
|
| 2011 |
Bruick RK, Gardner KH, MacMillan J, Tambar U. Modulation of HIF-2 Function with Small Molecules: Did Nature Beat Us to It? Blood. 118: SCI-39-SCI-39. DOI: 10.1182/Blood.V118.21.Sci-39.Sci-39 |
0.452 |
|
| 2011 |
Di L, Fernandez A, Gardner K. Abstract 226: Transcriptional control of the BRCA1 expression by a metabolic switch Cancer Research. 71: 226-226. DOI: 10.1158/1538-7445.Am2011-226 |
0.32 |
|
| 2011 |
Gardner KH. Ligand-Regulated Protein/Protein Interactions: A Versatile Way to Build an Environmental Sensor Biophysical Journal. 100: 26a. DOI: 10.1016/J.Bpj.2010.12.349 |
0.527 |
|
| 2011 |
Gardner KH, Mittermaier A, Mulder FAA. A tribute to Lewis e Kay on his 50th birthday Journal of Biomolecular Nmr. 51: 3-4. DOI: 10.1007/s10858-011-9561-x |
0.517 |
|
| 2010 |
Motta-Mena LB, Partch CL, Gardner KH. The three Rs of transcription: recruit, retain, and recycle. Molecular Cell. 40: 855-8. PMID 21172650 DOI: 10.1016/J.Molcel.2010.12.010 |
0.786 |
|
| 2010 |
Akella R, Min X, Wu Q, Gardner KH, Goldsmith EJ. The third conformation of p38α MAP kinase observed in phosphorylated p38α and in solution Structure. 18: 1571-1578. PMID 21134636 DOI: 10.1016/J.Str.2010.09.015 |
0.426 |
|
| 2010 |
Strickland D, Yao X, Gawlak G, Rosen MK, Gardner KH, Sosnick TR. Rationally improving LOV domain-based photoswitches. Nature Methods. 7: 623-6. PMID 20562867 DOI: 10.1038/Nmeth.1473 |
0.595 |
|
| 2010 |
Lehotzky RE, Partch CL, Mukherjee S, Cash HL, Goldman WE, Gardner KH, Hooper LV. Molecular basis for peptidoglycan recognition by a bactericidal lectin. Proceedings of the National Academy of Sciences of the United States of America. 107: 7722-7. PMID 20382864 DOI: 10.1073/Pnas.0909449107 |
0.664 |
|
| 2010 |
Partch CL, Gardner KH. Coactivator recruitment: a new role for PAS domains in transcriptional regulation by the bHLH-PAS family. Journal of Cellular Physiology. 223: 553-7. PMID 20112293 DOI: 10.1002/Jcp.22067 |
0.707 |
|
| 2010 |
Di L, Fernandez A, Gardner K. Abstract 1116: Epigenetic control of the BRCA1 expression by a metabolic switch Cancer Research. 70: 1116-1116. DOI: 10.1158/1538-7445.Am10-1116 |
0.313 |
|
| 2009 |
Key J, Scheuermann TH, Anderson PC, Daggett V, Gardner KH. Principles of ligand binding within a completely buried cavity in HIF2α PAS-B Journal of the American Chemical Society. 131: 17647-17654. PMID 19950993 DOI: 10.1021/Ja9073062 |
0.815 |
|
| 2009 |
Evans MR, Gardner KH. Slow transition between two β-strand registers is dictated by protein unfolding Journal of the American Chemical Society. 131: 11306-11307. PMID 19722642 DOI: 10.1021/Ja9048338 |
0.606 |
|
| 2009 |
De Siervi A, De Luca P, Moiola C, Gueron G, Tongbai R, Chandramouli GVR, Haggerty C, Dzekunova I, Petersen D, Kawasaki E, Whoon JK, Camphausen K, Longo D, Gardner K. Identification of new Rel/NFκB regulatory networks by focused genome location analysis Cell Cycle. 8: 2093-2100. PMID 19502793 DOI: 10.4161/Cc.8.13.8926 |
0.318 |
|
| 2009 |
Partch CL, Card PB, Amezcua CA, Gardner KH. Molecular basis of coiled coil coactivator recruitment by the aryl hydrocarbon receptor nuclear translocator (ARNT). The Journal of Biological Chemistry. 284: 15184-92. PMID 19324882 DOI: 10.1074/Jbc.M808479200 |
0.815 |
|
| 2009 |
Evans MR, Card PB, Gardner KH. ARNT PAS-B has a fragile native state structure with an alternative β-sheet register nearby in sequence space Proceedings of the National Academy of Sciences of the United States of America. 106: 2617-2622. PMID 19196990 DOI: 10.1073/Pnas.0808270106 |
0.831 |
|
| 2009 |
Wu Q, Gardner KH. Structure and insight into blue light-induced changes in the BlrP1 BLUF domain Biochemistry. 48: 2620-2629. PMID 19191473 DOI: 10.1021/Bi802237R |
0.546 |
|
| 2009 |
Scheuermann TH, Tomchick DR, Machius M, Guo Y, Bruick RK, Gardner KH. Artificial ligand binding within the HIF2α PAS-B domain of the HIF2 transcription factor Proceedings of the National Academy of Sciences of the United States of America. 106: 450-455. PMID 19129502 DOI: 10.1073/Pnas.0808092106 |
0.82 |
|
| 2009 |
Mukherjee S, Partch CL, Lehotzky RE, Whitham CV, Chu H, Bevins CL, Gardner KH, Hooper LV. Regulation of C-type lectin antimicrobial activity by a flexible N-terminal prosegment. The Journal of Biological Chemistry. 284: 4881-8. PMID 19095652 DOI: 10.1074/Jbc.M808077200 |
0.699 |
|
| 2009 |
Evans M, Card P, Gardner K. Human ARNT C-Terminal PAS Domain, 3 Residue IB slip Journal of Back and Musculoskeletal Rehabilitation. DOI: 10.2210/Pdb2K7S/Pdb |
0.8 |
|
| 2008 |
Nash AI, Ko WH, Harper SM, Gardner KH. A conserved glutamine plays a central role in LOV domain signal transmission and its duration. Biochemistry. 47: 13842-9. PMID 19063612 DOI: 10.1021/Bi801430E |
0.828 |
|
| 2008 |
Wu Q, Ko WH, Gardner KH. Structural requirements for key residues and auxiliary portions of a BLUF domain Biochemistry. 47: 10271-10280. PMID 18771279 DOI: 10.1021/Bi8011687 |
0.734 |
|
| 2008 |
Sakiyama H, Wynn RM, Lee WR, Fukasawa M, Mizuguchi H, Gardner KH, Repa JJ, Uyeda K. Regulation of nuclear import/export of carbohydrate response element-binding protein (ChREBP): Interaction of anα-helix of ChREBP with the 14-3-3 proteins and regulation by phosphorylation Journal of Biological Chemistry. 283: 24899-24908. PMID 18606808 DOI: 10.1074/Jbc.M804308200 |
0.396 |
|
| 2008 |
Yao X, Rosen MK, Gardner KH. Estimation of the available free energy in a LOV2-Jα photoswitch Nature Chemical Biology. 4: 491-497. PMID 18604202 DOI: 10.1038/Nchembio.99 |
0.619 |
|
| 2008 |
Lee J, Tomchick DR, Brautigam CA, Machius M, Kort R, Hellingwerf KJ, Gardner KH. Changes at the KinA PAS-A dimerization interface influence histidine kinase function Biochemistry. 47: 4051-4064. PMID 18324779 DOI: 10.1021/Bi7021156 |
0.572 |
|
| 2007 |
Scheuermann TH, Yang J, Zhang L, Gardner KH, Bruick RK. Hypoxia-Inducible Factors Per/ARNT/Sim Domains: Structure and Function Methods in Enzymology. 435: 1,3-24. PMID 17998046 DOI: 10.1016/S0076-6879(07)35001-5 |
0.809 |
|
| 2007 |
Ko WH, Nash AI, Gardner KH. A LOVely view of blue light photosensing. Nature Chemical Biology. 3: 372-4. PMID 17576422 DOI: 10.1038/Nchembio0707-372 |
0.808 |
|
| 2007 |
Idelman G, Taylor JG, Tongbai R, Chen RA, Haggerty CM, Bilke S, Chanock SJ, Gardner K. Functional profiling of uncommon VCAM1 promoter polymorphisms prevalent in African American populations Human Mutation. 28: 824-829. PMID 17431880 DOI: 10.1002/Humu.20523 |
0.302 |
|
| 2007 |
Yao X, Gardner K, Rosen M. Lit‐structure in the dark: conformational dynamics of phototropin LOV2 domain by relaxation NMR The Faseb Journal. 21. DOI: 10.1096/Fasebj.21.5.A270-B |
0.593 |
|
| 2006 |
Kajimura J, Rahman A, Hsu J, Evans MR, Gardner KH, Rick PD. O acetylation of the enterobacterial common antigen polysaccharide is catalyzed by the product of the yiaH gene of Escherichia coli K-12 Journal of Bacteriology. 188: 7542-7550. PMID 16936038 DOI: 10.1128/Jb.00783-06 |
0.499 |
|
| 2006 |
Colbert CL, Wu Q, Erbel PJ, Gardner KH, Deisenhofer J. Mechanism of substrate specificity in Bacillus subtilis ResA, a thioredoxin-like protein involved in cytochrome c maturation. Proceedings of the National Academy of Sciences of the United States of America. 103: 4410-5. PMID 16537372 DOI: 10.1073/Pnas.0600552103 |
0.784 |
|
| 2006 |
Taylor JG, Idelman G, Tongbai R, Chen RA, Haggerty CM, Chanock SJ, Gardner K. vRare VCAM1 Promoter Haplotypes Prevalent in African Americans Are Hyperinducible. Blood. 108: 1813-1813. DOI: 10.1182/Blood.V108.11.1813.1813 |
0.328 |
|
| 2005 |
Card PB, Erbel PJA, Gardner KH. Structural basis of ARNT PAS-B dimerization: Use of a common beta-sheet interface for hetero- and homodimerization Journal of Molecular Biology. 353: 664-677. PMID 16181639 DOI: 10.1016/J.Jmb.2005.08.043 |
0.812 |
|
| 2005 |
Socolich M, Lockless SW, Russ WP, Lee H, Gardner KH, Ranganathan R. Evolutionary information for specifying a protein fold. Nature. 437: 512-8. PMID 16177782 DOI: 10.1038/Nature03991 |
0.359 |
|
| 2005 |
Gardner KH, Montminy M. Can you hear me now? Regulating transcriptional activators by phosphorylation. Science's Stke : Signal Transduction Knowledge Environment. 2005: pe44. PMID 16160121 DOI: 10.1126/Stke.3012005Pe44 |
0.362 |
|
| 2005 |
Yang J, Zhang L, Erbel PJA, Gardner KH, Ding K, Garcia JA, Bruick RK. Functions of the Per/ARNT/Sim domains of the hypoxia-inducible factor Journal of Biological Chemistry. 280: 36047-36054. PMID 16129688 DOI: 10.1074/Jbc.M501755200 |
0.81 |
|
| 2005 |
Jung A, Domratcheva T, Tarutina M, Wu Q, Ko WH, Shoeman RL, Gomelsky M, Gardner KH, Schlichting I. Structure of a bacterial BLUF photoreceptor: Insights into blue light-mediated signal transduction Proceedings of the National Academy of Sciences of the United States of America. 102: 12350-12355. PMID 16107542 DOI: 10.1073/Pnas.0500722102 |
0.742 |
|
| 2005 |
Card PB, Gardner KH. Identification and optimization of protein domains for NMR studies. Methods in Enzymology. 394: 3-16. PMID 15808215 DOI: 10.1016/S0076-6879(05)94001-9 |
0.795 |
|
| 2005 |
Sohn RH, Deming CB, Johns DC, Champion HC, Bian C, Gardner K, Rade JJ. Regulation of endothelial thrombomodulin expression by inflammatory cytokines is mediated by activation of nuclear factor-kappa B Blood. 105: 3910-3917. PMID 15677570 DOI: 10.1182/Blood-2004-03-0928 |
0.34 |
|
| 2004 |
Harper SM, Christie JM, Gardner KH. Disruption of the LOV-Jalpha helix interaction activates phototropin kinase activity. Biochemistry. 43: 16184-92. PMID 15610012 DOI: 10.1021/Bi048092I |
0.833 |
|
| 2004 |
Best JL, Amezcua CA, Mayr B, Flechner L, Murawsky CM, Emerson B, Zor T, Gardner KH, Montminy M. Identification of small-molecule antagonists that inhibit an activator: coactivator interaction. Proceedings of the National Academy of Sciences of the United States of America. 101: 17622-7. PMID 15585582 DOI: 10.1073/Pnas.0406374101 |
0.81 |
|
| 2004 |
Galperin MM, Traicoff JL, Ramesh A, Freebern WJ, Haggerty CM, Hartmann DP, Emmert-Buck MR, Gardner K, Knezevic V. Multimembrane dot-blotting: A cost-effective tool for proteome analysis Biotechniques. 36: 1046-1051. PMID 15211757 DOI: 10.2144/04366Pf01 |
0.318 |
|
| 2004 |
Harper SM, Neil LC, Day IJ, Hore PJ, Gardner KH. Conformational changes in a photosensory LOV domain monitored by time-resolved NMR spectroscopy. Journal of the American Chemical Society. 126: 3390-1. PMID 15025443 DOI: 10.1021/Ja038224F |
0.811 |
|
| 2004 |
Erbel PJ, Seidel R, Macintosh SE, Gentile LN, Amor JC, Kahn RA, Prestegard JH, McIntosh LP, Gardner KH. Cyclic enterobacterial common antigen: potential contaminant of bacterially expressed protein preparations. Journal of Biomolecular Nmr. 29: 199-204. PMID 15014233 DOI: 10.1023/B:Jnmr.0000019252.65073.24 |
0.79 |
|
| 2003 |
Erbel PJ, Card PB, Karakuzu O, Bruick RK, Gardner KH. Structural basis for PAS domain heterodimerization in the basic helix--loop--helix-PAS transcription factor hypoxia-inducible factor. Proceedings of the National Academy of Sciences of the United States of America. 100: 15504-9. PMID 14668441 DOI: 10.1073/Pnas.2533374100 |
0.833 |
|
| 2003 |
Harper SM, Neil LC, Gardner KH. Structural basis of a phototropin light switch. Science (New York, N.Y.). 301: 1541-4. PMID 12970567 DOI: 10.1126/Science.1086810 |
0.819 |
|
| 2003 |
Smith JL, Collins I, Chandramouli GV, Butscher WG, Zaitseva E, Freebern WJ, Haggerty CM, Doseeva V, Gardner K. Targeting combinatorial transcriptional complex assembly at specific modules within the interleukin-2 promoter by the immunosuppressant SB203580. The Journal of Biological Chemistry. 278: 41034-46. PMID 12896977 DOI: 10.1074/Jbc.M305615200 |
0.324 |
|
| 2003 |
Erbel PJ, Barr K, Gao N, Gerwig GJ, Rick PD, Gardner KH. Identification and biosynthesis of cyclic enterobacterial common antigen in Escherichia coli. Journal of Bacteriology. 185: 1995-2004. PMID 12618464 DOI: 10.1128/Jb.185.6.1995-2004.2003 |
0.761 |
|
| 2002 |
Amezcua CA, Harper SM, Rutter J, Gardner KH. Structure and interactions of PAS kinase N-terminal PAS domain: model for intramolecular kinase regulation. Structure (London, England : 1993). 10: 1349-61. PMID 12377121 DOI: 10.1016/S0969-2126(02)00857-2 |
0.827 |
|
| 2002 |
Xiao T, Gardner KH, Sprang SR. Cosolvent-induced transformation of a death domain tertiary structure. Proceedings of the National Academy of Sciences of the United States of America. 99: 11151-6. PMID 12177432 DOI: 10.1073/Pnas.172188399 |
0.438 |
|
| 2002 |
He Q, Cheng P, Yang Y, Wang L, Gardner KH, Liu Y. White collar-1, a DNA binding transcription factor and a light sensor. Science (New York, N.Y.). 297: 840-3. PMID 12098705 DOI: 10.1126/Science.1072795 |
0.419 |
|
| 2002 |
Cheng P, Yang Y, Gardner KH, Liu Y. PAS domain-mediated WC-1/WC-2 interaction is essential for maintaining the steady-state level of WC-1 and the function of both proteins in circadian clock and light responses of Neurospora. Molecular and Cellular Biology. 22: 517-24. PMID 11756547 DOI: 10.1128/Mcb.22.2.517-524.2002 |
0.458 |
|
| 2001 |
Holdeman TC, Gardner KH. 1H, 13C and 15N chemical shift assignments of the N-terminal PAS domain of mNPAS2. Journal of Biomolecular Nmr. 21: 383-4. PMID 11824759 DOI: 10.1023/A:1013334608913 |
0.325 |
|
| 2001 |
Usher KC, Ozkan E, Gardner KH, Deisenhofer J. The plug domain of FepA, a TonB-dependent transport protein from Escherichia coli, binds its siderophore in the absence of the transmembrane barrel domain. Proceedings of the National Academy of Sciences of the United States of America. 98: 10676-81. PMID 11526207 DOI: 10.1073/Pnas.181353398 |
0.419 |
|
| 2001 |
Rutter J, Michnoff CH, Harper SM, Gardner KH, McKnight SL. PAS kinase: an evolutionarily conserved PAS domain-regulated serine/threonine kinase. Proceedings of the National Academy of Sciences of the United States of America. 98: 8991-6. PMID 11459942 DOI: 10.1073/Pnas.161284798 |
0.801 |
|
| 1999 |
Goto NK, Gardner KH, Mueller GA, Willis RC, Kay LE. A robust and cost-effective method for the production of Val, Leu, Ile (delta 1) methyl-protonated 15N-, 13C-, 2H-labeled proteins. Journal of Biomolecular Nmr. 13: 369-74. PMID 10383198 DOI: 10.1023/A:1008393201236 |
0.711 |
|
| 1998 |
Yang D, Gardner KH, Kay LE. A Sensitive Pulse Scheme for Measuring the Backbone Dihedral Angle psi Based on Cross-correlation Between (13)C (alpha)- (1)Halpha Dipolar and Carbonyl Chemical Shift Anisotropy Relaxation Interactions. Journal of Biomolecular Nmr. 11: 213-20. PMID 20700829 DOI: 10.1023/A:1008284315816 |
0.492 |
|
| 1998 |
Shan X, Gardner KH, Muhandiram DR, Kay LE, Arrowsmith CH. Subunit-specific backbone NMR assignments of a 64 kDa trp repressor/DNA complex: a role for N-terminal residues in tandem binding. Journal of Biomolecular Nmr. 11: 307-18. PMID 9691278 DOI: 10.1023/A:1008257803130 |
0.56 |
|
| 1998 |
Gardner KH, Kay LE. The use of 2H, 13C, 15N multidimensional NMR to study the structure and dynamics of proteins. Annual Review of Biophysics and Biomolecular Structure. 27: 357-406. PMID 9646872 DOI: 10.1146/Annurev.Biophys.27.1.357 |
0.517 |
|
| 1998 |
Gardner KH. Solution NMR studies of a 42 KDa Escherichia coli maltose binding protein/β-cyclodextrin complex: Chemical shift assignments and analysis Journal of the American Chemical Society. 120: 11738-11748. DOI: 10.1021/Ja982019W |
0.346 |
|
| 1998 |
Zwahlen C, Gardner KH, Sarma SP, Horita DA, Byrd RA, Kay LE. An NMR experiment for measuring methyl-methyl NOEs in 13C-labeled proteins with high resolution Journal of the American Chemical Society. 120: 7617-7625. DOI: 10.1021/Ja981205Z |
0.545 |
|
| 1998 |
Zwahlen C, Vincent SJF, Gardner KH, Kay LE. Significantly improved resolution for noe correlations from valine and isoleucine (C(y)2) methyl groups in 15N, 13C- and 15N, 13C, 2H-labeled proteins Journal of the American Chemical Society. 120: 4825-4831. DOI: 10.1021/Ja9742601 |
0.488 |
|
| 1997 |
Kay LE, Gardner KH. Solution NMR spectroscopy beyond 25 kDa. Current Opinion in Structural Biology. 7: 722-31. PMID 9345633 DOI: 10.1016/S0959-440X(97)80084-X |
0.48 |
|
| 1997 |
Gardner KH, Rosen MK, Kay LE. Global folds of highly deuterated, methyl-protonated proteins by multidimensional NMR. Biochemistry. 36: 1389-401. PMID 9063887 DOI: 10.1021/Bi9624806 |
0.652 |
|
| 1997 |
Gardner KH, Kay LE. Production and incorporation of 15N, 13C, 2H (1H-δ1 methyl) isoleucine into proteins for multidimensional NMR studies Journal of the American Chemical Society. 119: 7599-7600. DOI: 10.1021/Ja9706514 |
0.465 |
|
| 1997 |
Coleman JE, Rodgers KK, Junker M, Gardner KH, Bellon SF, Steitz TA. Zinc as a structural and folding element of proteins which interact with DNA Journal of Inorganic Biochemistry. 67: 342. DOI: 10.1016/S0162-0134(97)80209-7 |
0.553 |
|
| 1996 |
Gardner KH, Konrat R, Rosen MK, Kay LE. An (H)C(CO)NH-TOCSY pulse scheme for sequential assignment of protonated methyl groups in otherwise deuterated (15)N, (13)C-labeled proteins. Journal of Biomolecular Nmr. 8: 351-6. PMID 20686885 DOI: 10.1007/Bf00410333 |
0.63 |
|
| 1996 |
Rosen MK, Gardner KH, Willis RC, Parris WE, Pawson T, Kay LE. Selective methyl group protonation of perdeuterated proteins. Journal of Molecular Biology. 263: 627-36. PMID 8947563 DOI: 10.1006/Jmbi.1996.0603 |
0.667 |
|
| 1996 |
Shan X, Gardner KH, Muhandiram DR, Rao NS, Arrowsmith CH, Kay LE. Assignment of 15N, 13C(α), 13C(β), and HN resonances in an 15N,13C,2H labeled 64 kDa trp repressor-operator complex using triple-resonance NMR spectroscopy and 2H-decoupling Journal of the American Chemical Society. 118: 6570-6579. DOI: 10.1021/Ja960627A |
0.494 |
|
| 1995 |
Schweitzer BI, Gardner KH, Tucker-Kellogg G. HeteroTOCSY-based experiments for measuring heteronuclear relaxation in nucleic acids and proteins. Journal of Biomolecular Nmr. 6: 180-8. PMID 8589607 DOI: 10.1007/Bf00211782 |
0.313 |
|
| 1995 |
Klemba M, Gardner KH, Marino S, Clarke ND, Regan L. Novel metal-binding proteins by design. Nature Structural Biology. 2: 368-73. PMID 7664093 DOI: 10.1038/Nsb0595-368 |
0.404 |
|
| 1995 |
Gardner KH, Anderson SF, Coleman JE. Solution structure of the Kluyveromyces lactis LAC9 Cd2 Cys6 DNA-binding domain. Nature Structural Biology. 2: 898-905. PMID 7552715 DOI: 10.1038/Nsb1095-898 |
0.603 |
|
| 1994 |
Schweitzer BI, Mikita T, Kellogg GW, Gardner KH, Beardsley GP. Solution structure of a DNA dodecamer containing the anti-neoplastic agent arabinosylcytosine: combined use of NMR, restrained molecular dynamics, and full relaxation matrix refinement. Biochemistry. 33: 11460-75. PMID 7918360 DOI: 10.1021/Bi00204A008 |
0.306 |
|
| 1994 |
Gardner KH, Coleman JE. 113Cd-1H heteroTOCSY: a method for determining metal-protein connectivities. Journal of Biomolecular Nmr. 4: 761-74. PMID 7812152 DOI: 10.1007/Bf00398407 |
0.524 |
|
| 1991 |
Gardner KH, Pan T, Narula S, Rivera E, Coleman JE. Structure of the binuclear metal-binding site in the GAL4 transcription factor. Biochemistry. 30: 11292-302. PMID 1958667 DOI: 10.1021/Bi00111A015 |
0.562 |
|
| 1991 |
Coleman JE, Pan T, Gardner K. Solution structure of the DNA binding domain of the transcription factor GAL4 as determined by 2d NMR methods. Journal of Inorganic Biochemistry. 43: 509. DOI: 10.1016/0162-0134(91)84486-S |
0.59 |
|
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